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https://www.readbyqxmd.com/read/29165678/the-genealogy-of-dementia-praecox-i-signs-and-symptoms-of-delusional-psychoses-from-1880-to-1900
#1
Kenneth S Kendler
We can trace, with high congruence, the clinical syndromes of depression and mania as described over the 20th century in psychiatric textbooks back to 1880 and to the earliest writing of Kraepelin published in 1883. However, this is not the case for Kraepelin's 2 delusional syndromes central to his overall nosology: Dementia Paranoides (later paranoid schizophrenia) and Paranoia. A detailed examination of 28 textbook descriptions of delusional psychoses from 1880 to 1900 reveals a diverse and partially overlapping set of syndromes with an admixture of symptoms and signs that would later be considered indicative of Dementia Paranoides and Paranoia...
November 19, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29156414/schizophrenia-heterogeneity-revisited-clinical-cognitive-and-psychosocial-correlates-of-statistically-derived-negative-symptoms-subgroups
#2
Anthony O Ahmed, Gregory P Strauss, Robert W Buchanan, Brian Kirkpatrick, William T Carpenter
Traditional efforts to delineate the clinical heterogeneity of schizophrenia have been unsuccessful because of the absence of a valid, stable, and meaningful subtyping scheme. A clinically-informed nosology supported by multivariate statistical classification methods may provide a better approach for classifying schizophrenia. The goals of the current study were to 1) use multivariate classification methods to validate a clinical subtyping scheme based on the profile of negative symptoms; and 2) following validation to contrast the statistically-derived subgroups to ascertain distinguishing demographic, clinical, cognitive, and functional characteristics...
November 12, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29130695/a-test-of-the-empirical-profile-and-coherence-of-the-dsm-5-psychopathy-specifier
#3
Joshua D Miller, Joanna Lamkin, Jessica L Maples-Keller, Chelsea E Sleep, Donald R Lynam
The Diagnostic and Statistical Manual of Mental Disorders-5th edition (DSM-5; American Psychiatric Association, 2013) introduced a psychopathy specifier (DSM-5 PS) as part of the Section III diagnostic model of antisocial personality disorder. Designed to capture the construct of fearless dominance/boldness, the DSM-5 PS is assessed on the basis of the presence of low scores on traits of withdrawal and anxiousness, and high scores on attention seeking. These constructs have garnered attention in the past decade but are the subject of substantial debate as to their role in the conceptualization and assessment of psychopathy, given their limited relations to the maladaptive outcomes typically associated with this personality disorder...
November 13, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/29124003/inflammatory-myofibroblastic-tumour-a-case-report-and-a-clinical-update
#4
Neelam N Andrade, Paul C Mathai, Rajpari Kamil, Neha Aggarwal
The Inflammatory myofibroblastic tumor (IMT) is a heterogeneous group of rare lesions consisting predominantly of inflammatory cells and myofibroblastic spindle cells. Head and neck IMTs account for 14 to 18% of extra-pulmonary IMTs [lungs being the most commonly affected regions]. On account of its ambiguous clinical presentation, an IMT needs to be differentiated from other infectious, granulomatous, autoimmune and neoplastic lesions on the basis of histopathologic findings and immunohistochemical analysis...
September 2017: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/29119914/obsessive-compulsive-disorder-with-comorbid-bipolar-disorders-clinical-features-and-treatment-implications
#5
Federico Mucci, Cristina Toni, Ettore Favaretto, Giulia Vannucchi, Donatella Marazziti, Giulio Perugi
BACKGROUND: Obsessive-compulsive disorder (OCD) symptoms within the context of a bipolar disorder (BD) have been described since the 19th century. Interestingly, the existence of a relevant overlap between the aforementioned psychiatric syndromes has been confirmed by a number of recent epidemiological and family studies. AIMS: The aim of the present paper is to review the clinical features and the therapeutic implications of the OCD-BD comorbidity. DISCUSSION: In the last two decades, the frequent association between OCD and BD has been earning a growing interest given its relevant nosological and therapeutic implications...
November 8, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29114468/classification-of-pulmonary-neuroendocrine-tumors-new-insights
#6
REVIEW
Giuseppe Pelosi, Angelica Sonzogni, Sergio Harari, Adriana Albini, Enrica Bresaola, Caterina Marchiò, Federica Massa, Luisella Righi, Gaia Gatti, Nikolaos Papanikolaou, Namrata Vijayvergia, Fiorella Calabrese, Mauro Papotti
Neuroendocrine tumors of the lung (Lu-NETs) embrace a heterogeneous family of neoplasms classified into four histological variants, namely typical carcinoid (TC), atypical carcinoid (AC), large cell neuroendocrine carcinoma (LCNEC) and small cell lung carcinoma (SCLC). Defining criteria on resection specimens include mitotic count in 2 mm(2) and the presence or absence of necrosis, alongside a constellation of cytological and histological traits including cell size and shape, nuclear features and overall architecture...
October 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29110997/spinal-nerve-involvement-in-early-guillain-barr%C3%A3-syndrome-the-haymaker-and-kernohan-s-legacy
#7
REVIEW
José Berciano
Pathological studies of early Guillain-Barré syndrome (GBS), defined as of 10days of disease onset, are scanty making it difficult to interpret the physiopathology of clinical and electrophysiological features. In 1949, Webb Haymaker and James Kernohan reported 50 clinico-pathological studies of fatal GBS cases, 32 of them having died between days 2 and 10 after onset. They established that the brunt of initial lesions, consisting of endoneurial oedema interpreted as degenerative, relied on spinal nerves. That this oedema was inflammatory was soon thereafter recognized...
November 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29092102/nosologic-considerations-in-disorders-of-consciousness
#8
James L Bernat
No abstract text is available yet for this article.
November 1, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29083330/peculiarities-of-autoimmune-polyglandular-syndromes-in-children-and-adolescents
#9
Giuseppina Zirilli, Simona Santucci, Chiara Cuzzupè, Domenico Corica, Elda Pitrolo, Giuseppina Salzano
BACKGROUND: no reviews have specifically addressed , to now, whether autoimmune polyglandular syndromes (APSs) may have a peculiar epidemiology and phenotypical expression in pediatric ageObjectives: to review the most recent literature data about the specific epidemiological and clinical peculiarities of APSs in childhood and adolescenceDesign: the main features of the different APSs in pediatric age were compared among them. CONCLUSIONS: 1) Among the different APSs, the one that is most typical of pediatric age is APS-1; 2) APS-1 is not characterized only by the classical triad (chronic moniliasis-hyposurrenalism-hypoparathyroidism) and its clinical spectrum is enlarging over time; 3)APS-2 may have a different epidemiological and clinical expression according to two different nosological classifications...
October 23, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29073632/jean-martin-charcot-1825-1893-a-treatment-approach-gone-astray
#10
Olivier Walusinski
Jean-Martin Charcot's reputation remains that of a physician who took little interest in treatments for the neurological diseases he did much to identify. After reviewing the limited number of medicinal remedies of slight effectiveness at Charcot's disposal, we analyze in this review the numerous therapeutic tests that he conducted: vibratory medicine for Parkinson's disease, treatment of tabes by suspension technique, metallotherapy and moral -treatment for hysteria. Understanding that he fully and completely adhered to the far-reaching heredity-based theories of his day makes it possible to perceive his natural and fundamental pessimism...
October 26, 2017: European Neurology
https://www.readbyqxmd.com/read/29057520/editorial-minding-the-gap-research-on-sexual-minority-and-gender-nonconforming-children-and-adolescents
#11
EDITORIAL
Charles H Zeanah, Myo Thwin Myint
There is often a gap between politics and science, but the influence across the gap is bidirectional. This editorial considers a longitudinal, community-based sample of children and adolescents and asks about risks from early childhood gender non-conformity and adolescent reported sexual minority status for subsequent anxiety disorders. It is especially valuable to have longitudinal data from a non-referred sample to address questions of risk, and the investigators must be complemented for having foresight about these questions twenty years ago...
November 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29051203/anterior-circulation-acute-ischemic-stroke-associated-with-atherosclerotic-lesions-of-the-cervical-ica-a-nosologic-entity-apart
#12
O F Eker, P Panni, C Dargazanli, G Marnat, C Arquizan, P Machi, I Mourand, G Gascou, E Le Bars, V Costalat, A Bonafé
BACKGROUND AND PURPOSE: Mechanical thrombectomy for patients with acute ischemic stroke with tandem occlusions has been shown to present varying reperfusion successes and clinical outcomes. However, the heterogeneity of tandem occlusion etiology has been strongly neglected in previous studies. We retrospectively investigated patients with acute ischemic stroke atherothrombotic tandem occlusion. MATERIALS AND METHODS: All consecutive patients with acute ischemic stroke with atherothrombotic tandem occlusions treated with mechanical thrombectomy in our center between September 2009 and April 2015 were analyzed...
October 19, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29046034/-neurological-manifestations-in-atypical-kawasaki-disease
#13
Edgar Martínez-Guzmán, Luisa Berenise Gámez-González, Francisco Rivas-Larrauri, Giovanni Sorcia-Ramírez, Marco Yamazaki-Nakashimada
BACKGROUND: Kawasaki disease (KD) is a type of systemic vasculitis of unknown etiology. Atypical Kawasaki disease is defined as that where there are signs and symptoms not corresponding to the classical criteria for this nosological entity. Children with atypical Kawasaki disease may present with acute abdominal symptoms, meningeal irritation, pneumonia or renal failure. CLINICAL CASES: We describe 4 children with ages ranging from 2 to 12 years who had atypical Kawasaki disease, with neurological and gastrointestinal symptoms as part of the systemic presentation of the disease...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29043155/catatonia-as-a-putative-nosological-entity-a-historical-sketch
#14
REVIEW
Gábor Gazdag, Rozalia Takács, Gabor S Ungvari
Kahlbaum was the first to propose catatonia as a separate disease following the example of general paresis of the insane, which served as a model for establishing a nosological entity. However, Kahlbaum was uncertain about the nosological position of catatonia and considered it a syndrome, or "a temporary stage or a part of a complex picture of various disease forms". Until recently, the issue of catatonia as a separate diagnostic category was not entertained, mainly due to a misinterpretation of Kraepelin's influential views on catatonia as a subtype of schizophrenia...
September 22, 2017: World Journal of Psychiatry
https://www.readbyqxmd.com/read/29037904/rheumatic-diseases-and-autoimmune-vascular-dementia
#15
REVIEW
Fabiola Atzeni, Nicolò Pipitone, Luca Iaccarino, Ignazio Francesco Masala, Ronen Weiss, Alessandra Alciati, Andrea Doria, Joab Chapmanand, Piercarlo Sarzi-Puttini
Vascular dementia (VD) comes second after Alzheimer's disease (AD) as a cause of impaired cognition. VD is not a specific nosological entity, but rather a syndrome encompassing a number of diseases caused by impaired supply of blood to the brain. Systemic autoimmune disorders such as systemic lupus erythematosus, rheumatoid arthritis, vasculitis and antiphospholipid syndrome (APS) can be associated with dementia. VD is often related to the presence of traditional cardiovascular risk factors, but it may also be associated with a host of disorders affecting the brain blood vessels, neuronal cells, or both...
October 14, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29036668/neurobiological-commonalities-and-distinctions-among-three-major-psychiatric-diagnostic-categories-a-structural-mri-study
#16
Miao Chang, Fay Y Womer, E Kale Edmiston, Chuan Bai, Qian Zhou, Xiaowei Jiang, Shengnan Wei, Yange Wei, Yuting Ye, Haiyan Huang, Yong He, Ke Xu, Yanqing Tang, Fei Wang
BACKGROUND: Schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD) are distinct diagnostic categories in current psychiatric nosology, yet there is increasing evidence for shared clinical and biological features in these disorders. No previous studies have examined brain structural features concurrently in these 3 disorders. The aim of this study was to identify the extent of shared and distinct brain alterations in SZ, BD, and MDD. We examined gray matter (GM) volume and white matter (WM) integrity in a total of 485 individuals (135 with SZ, 86 with BD, 108 with MDD, and 156 healthy controls [HC]) who underwent high-resolution structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) at a single site...
June 13, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29031920/kraepelin-s-crumbling-twin-pillars-using-biology-to-reconstruct-psychiatric-nosology-from-the-bottom-up
#17
Joao P De Aquino, David A Ross
No abstract text is available yet for this article.
November 15, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29024828/a-classical-ehlers-danlos-syndrome-family-with-incomplete-presentation-diagnosed-by-molecular-testing
#18
Marina Colombi, Chiara Dordoni, Valeria Cinquina, Marina Venturini, Marco Ritelli
The 2017 EDS revised nosology indicates that minimal criteria suggestive for classical Ehlers-Danlos syndrome (cEDS) are skin hyperextensibility plus atrophic scarring together with either generalized joint hypermobility (gJHM) and/or at least three minor criteria that include cutaneous features and gJHM complications. Confirmatory molecular testing is obligatory to reach a final diagnosis. Although the large majority of the patients presents with these clinical features, some do not and might remain undiagnosed or misdiagnosed...
October 9, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29017626/case-series-of-mild-behavioral-impairment-toward-an-understanding-of-the-early-stages-of-neurodegenerative-diseases-affecting-behavior-and-cognition
#19
Alicja Cieslak, Eric E Smith, John Lysack, Zahinoor Ismail
Mild behavioral impairment (MBI) is characterized by later life acquired, sustained, and impactful neuropsychiatric symptoms (NPS) of any severity that cannot be better accounted for by other formal medical and psychiatric nosology. MBI is an "at risk" state for incident cognitive decline and dementia, and for some, MBI is the index manifestation of neurodegeneration, observed in advance of cognitive impairment. Initially described in Frontotemporal Dementia (FTD), MBI evolved to describe a preclinical stage of all cause dementia, and has been operationalized in the International Society to Advance Alzheimer's Research and Treatment-Alzheimer's Association (ISTAART-AA) proposed research diagnostic criteria...
October 11, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28993504/precision-transplant-medicine-biomarkers-to-the-rescue
#20
Maarten Naesens, Dany Anglicheau
The concept that individuals with the same disease and a similar clinical presentation may have very different outcomes and need very different therapies is not novel. With the development of many innovative tools derived from the omics technologies, transplant medicine is slowly entering the era of precision medicine. Biomarkers are the cornerstone of precision medicine, which aims to integrate biomarkers with traditional clinical information and tailor medical care to achieve the best outcome for an individual patient...
October 9, 2017: Journal of the American Society of Nephrology: JASN
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