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https://www.readbyqxmd.com/read/28209102/diverticulitis-in-the-young-population%C3%A2-reconsidering-conventional-recommendations
#1
U Syed, R Companioni, R Bansal, H Alkhawam, A Walfish
BACKGROUND: In the past diverticulitis was believed to be uncommon in the young population. However, there is growing concern suggesting that these patients develop more severe clinical symptoms and may require more frequent intervention. METHOD: We performed a retrospective chart review of patients with diverticulitis in individuals with age less than 40 years over an 8 year period (2007-2015). Diagnosis was confirmed with a CT scan. In addition to age we took into consideration race, gender, anemia (hematocrit< 41), leukocytosis (WBC > 12), BMI and whether it was an initial episode or recurrence...
July 2016: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/28207993/comparison-of-jugular-and-transverse-facial-venous-sinus-blood-analytes-in-healthy-and-critically-ill-adult-horses
#2
Kara M Lascola, Karie Vander Werf, Stephanie Freese, Alison Morgera, David J Schaeffer, Pamela Wilkins
OBJECTIVE: To compare blood gas, electrolyte, and metabolic analysis results between blood obtained by jugular and transverse facial venous sinus (TFVS) venipuncture in healthy adult horses and sick adult horses presented for emergency evaluation. DESIGN: Prospective, experimental study, from June 2012 to October 2013. SETTING: Large animal university teaching hospital. ANIMALS: Ten healthy adult University-owned horses and 48 client-owned adult horses (≥2 years old) presenting to the large animal hospital emergency service for medical or surgical evaluation of systemic illness...
February 16, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28207540/different-dosages-of-mifepristone-versus-enantone-to-treat-uterine-fibroids-a-multicenter-randomized-controlled-trial
#3
Chongdong Liu, Qi Lu, Hong Qu, Li Geng, Meilu Bian, Minli Huang, Huilan Wang, Youzhong Zhang, Zeqing Wen, Shurong Zheng, Zhenyu Zhang
BACKGROUND: To evaluate the efficacy and safety of 10 mg and 25 mg mifepristone per day compared with 3.75 mg enantone in treating uterine fibroids. METHODS: This is a Multicenter randomized controlled trial. A total of 501 subjects with symptomatic uterine fibroids were enrolled and randomized into the group of 10mg, 25mg mifepristone and 3.75 enantone (with 307, 102 and 92 subjects respectively), with 458 subjects completed the treatment. Three months of daily therapy with oral mifepristone (at a dose of either 10 mg or 25 mg) or once-monthly subcutaneous injections of enantone (at a dose of 3...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28207503/clamping-drainage-is-unnecessary-after-minimally-invasive-total-knee-arthroplasty-in-patients-with-tranexamic-acid-a-randomized-controlled-trial
#4
Yuangang Wu, Timin Yang, Yi Zeng, Canfeng Li, Bin Shen, Fuxing Pei
BACKGROUND: Drainage and tranexamic acid (TXA) have been widely used in total knee arthroplasty (TKA). However, it remains unclear whether it is necessary to clamp the drain after minimally invasive TKA (MIS-TKA) when TXA is used. We therefore conducted a randomized controlled trial to compare the effects of clamping versus not clamping drainage following MIS-TKA in patients in whom TXA was used. METHODS: From January 2015 to December 2015, 121 patients undergoing unilateral primary MIS-TKA were enrolled and randomly divided into 2 groups...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28207416/are-aromatase-inhibitors-in-boys-with-predicted-short-stature-and-or-rapidly-advancing-bone-age-effective-and-safe
#5
Jessica A Ferris, Mitchell E Geffner
BACKGROUND: The aim of this study was to assess aromatase inhibitor (AI) efficacy in increasing predicted adult height (PAH) and to describe clinical and biochemical safety profiles of AI-treated boys. METHODS: A retrospective chart review was conducted at an academic children's hospital endocrinology clinic. Twenty-one boys with predicted short stature and/or rapidly advancing bone age, divided as Tanner stage (TS) I-III Group 1 (G1, n=9) and TS IV-V Group 2 (G2, n=12), were treated with AIs, either letrozole or anastrozole (mean duration, G1: 2...
February 16, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28197864/status-of-iron-metabolism-10-years-after-roux-en-y-gastric-bypass
#6
Daniela Vicinansa Monaco-Ferreira, Vânia Aparecida Leandro-Merhi
BACKGROUND: The aim of this study is to investigate changes in iron metabolism and verify whether biochemical parameters are related to the use of oral iron supplement 10 years after Roux-en-Y gastric bypass. METHODS: This longitudinal retrospective study included 151 patients submitted to Roux-en-Y gastric bypass. The collected data included use of an oral iron supplement, hemoglobin, hematocrit, serum iron, and ferritin. The chi-squared or Fisher's exact test was used to analyze the association between use of iron supplement and nutritional deficiency...
February 14, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28195648/hematology-and-biochemistry-of-aging-evidence-of-anemia-of-the-elderly-in-old-dogs
#7
Lauren B Radakovich, Stephen C Pannone, Matthew P Truelove, Christine S Olver, Kelly S Santangelo
BACKGROUND: Effects of aging on hematologic and biochemical variables are well described in people. Anemia of the elderly is attributed to iron deficiency, anemia of chronic disease, chronic kidney disease, myelodysplasia, or idiopathic causes. Limited studies have examined these variables in aging dogs, but they have typically examined single breeds in research settings. OBJECTIVE: The objective of this study was to identify differences in CBC and biochemistry values between adult and aged dogs of many breeds...
February 13, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28194196/assessment-of-hemodialysis-adequacy-and-its-relationship-with-individual-and-personal-factors
#8
Ozra Rezaiee, Nahid Shahgholian, Shahrzad Shahidi
BACKGROUND: Hemodialysis is the most common renal replacement therapy in the world, and hemodialysis adequacy is an important and influencial factor in the reduction of various complications experienced by these patients. Multiple factors influence hemodialysis adequacy. This study was conducted to determine hemodialysis adequacy and its relationship with individual and personal factors in patients undergoing hemodialysis in three hemodialysis centers of Isfahan, Iran. MATERIALS AND METHODS: This descriptive, cross-sectional study was conducted in partnership with 202 patients undergoing hemodialysis in three hemodialysis centers of Isfahan...
November 2016: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/28193568/markers-of-iron-deficiency-in-patients-with-polycythemia-vera-receiving-ruxolitinib-or-best-available-therapy
#9
Srdan Verstovsek, Claire N Harrison, Jean-Jacques Kiladjian, Carole Miller, Ahmad B Naim, Dilan C Paranagama, Dany Habr, Alessandro M Vannucchi
Polycythemia vera (PV) is characterized by erythropoiesis and JAK2-activating mutations, with increased risks of morbidity and mortality. Most patients with PV are iron deficient, and treatment often includes hematocrit control with phlebotomy, which may exacerbate iron deficiency-associated complications. The phase 3 RESPONSE trial evaluated the JAK1/JAK2 inhibitor ruxolitinib (n=110) versus best available therapy (BAT; n=112) in patients with PV who were hydroxyurea-resistant/intolerant. Ruxolitinib was superior to BAT for hematocrit control, reduction in splenomegaly, and blood count normalization...
January 31, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28193445/endovascular-management-for-peripheral-arterial-trauma-the-new-norm
#10
Anand Ganapathy, Ahmed F Khouqeer, S Robb Todd, Joseph L Mills, Ramyar Gilani
BACKGROUND: Endovascular therapy is well studied in atraumatic conditions; and there appears to be a growing interest in its application to traumatic injuries. The objective of this study is to compare open and endovascular techniques in the management of peripheral arterial trauma. METHODS: This is a retrospective review of patients admitted to a Level I Trauma Center sustaining injuries to the subclavian, axillary, superficial femoral, and popliteal arteries. Demographics, surgical interventions, complications, and clinical outcomes were evaluated in patients requiring open or endovascular repair between 2009 and 2015...
February 4, 2017: Injury
https://www.readbyqxmd.com/read/28191646/non-invasive-evaluation-of-blood-oxygen-saturation-and-hematocrit-from-t1-and-t2-relaxation-times-in-vitro-validation-in-fetal-blood
#11
Sharon Portnoy, Mike Seed, John G Sled, Christopher K Macgowan
PURPOSE: We propose an analytical method for calculating blood hematocrit (Hct) and oxygen saturation (sO2 ) from measurements of its T1 and T2 relaxation times. THEORY: Through algebraic substitution, established two-compartment relationships describing R1=T1-1 and R2=T2-1 as a function of hematocrit and oxygen saturation were rearranged to solve for Hct and sO2 in terms of R1 and R2 . Resulting solutions for Hct and sO2 are the roots of cubic polynomials. METHODS: Feasibility of the method was established by comparison of Hct and sO2 estimates obtained from relaxometry measurements (at 1...
February 12, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28189123/impact-of-various-progestins-with-or-without-transdermal-testosterone-on-gonadotropin-levels-for-non-invasive-hormonal-male-contraception-a-randomized-clinical-trial
#12
M Zitzmann, J Rohayem, J Raidt, S Kliesch, N Kumar, R Sitruk-Ware, E Nieschlag
Although several progestins have been tested for hormonal male contraception, the effects of dosage and nature of various progestins on gonadotropin suppression combined with and without additional testosterone has not been performed in a comparative trial. The aim of this study was to evaluate the differential impact of four oral or transdermal progestins on the suppression of gonadotropins in healthy men: oral: cyproterone acetate (CPA), levonorgestrel (LNG), norethisterone acetate (NETA), and transdermal: Nestorone(®) (NES), all in combination with transdermal testosterone (T)...
February 11, 2017: Andrology
https://www.readbyqxmd.com/read/28188952/risk-factors-for-central-serous-chorioretinopathy-in-pregnant-japanese-women
#13
Mamoru Morikawa, Kazutoshi Cho, Takashi Kojima, Kentaro Chiba, Satoshi Ishikawa, Takeshi Umazume, Kinuko Nakagawa, Takashi Yamada, Takahiro Yamada, Hisanori Minakami
AIM: This study was performed to determine risk factors for central serous chorioretinopathy (CSC) in pregnant women. METHODS: This retrospective observational study was performed in a cohort of all 1881 women giving birth at a single center. The hospital database was searched to abstract all women diagnosed with pre-eclampsia (PE) as well as those visiting the eye clinic during the current pregnancy. Medical chart review was performed in all women diagnosed with CSC and PE...
February 11, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28179232/kidney-specific-genetic-deletion-of-both-ampk-%C3%AE-subunits-causes-salt-and-water-wasting
#14
Yoskaly Lazo-Fernández, Goretti Baile, Patricia Meade, Pilar Torcal, Laura Martínez, Carmen Ibañez, Maria Luisa Bernal, Benoit Viollet, Ignacio Giménez
AMP-activated kinase (AMPK) controls cell energy homeostasis by modulating ATP synthesis and expenditure. In vitro studies have suggested AMPK may also control key elements of renal epithelial electrolyte transport but in vivo physiological confirmation is still insufficient. We studied sodium renal handling and extracellular volume regulation in mice with genetic deletion of AMPK catalytic subunits. AMPKα1 knockout (KO) mice exhibit normal renal sodium handling and a moderate antidiuretic state. This is accompanied by higher urinary aldosterone excretion rates and reduced blood pressure...
February 1, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28179171/extent-of-t1-c-intensity-is-a-predictor-of-blood-loss-in-resection-of-meningioma
#15
Ha Nguyen, Karl Janich, Ninh Doan, Mohit Patel, Luyuan Li, Wade Mueller
INTRODUCTION: Surgery for meningioma is associated with significant blood loss. Preoperative embolization has been associated with reduction of blood loss and has been noted to decrease intensity on T1 + contrast sequences. As such, we investigate potential relationships between blood loss and the extent of T1+ contrast intensity. MATERIALS AND METHODS: Forty-two patients who underwent surgical resection of intracranial meningioma were retrospectively reviewed from August 2009 to May 2016...
February 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28177382/effect-of-expeller-extracted-canola-meal-on-growth-performance-organ-weights-and-blood-parameters-of-growing-pigs
#16
D E Velayudhan, K Schuh, T A Woyengo, J S Sands, C M Nyachoti
The aim of this study was to assess the effects of increasing levels of expeller extracted canola meal (EECM) in diets for growing pigs on performance, gastrointestinal tract weight, thyroid gland weights, blood plasma concentration of triiodothyronine and tetraiodothyronine, red blood cell count, hemoglobin content in blood, and hematocrit. Four diets were fed to 48 pigs (19.9 ± 1.60 kg initial BW) in 24 pens (6 pens per diet) for 4 wk in a completely randomized design. The diets were a control corn-soybean meal basal diet and 3 additional diets produced by replacing 33, 66, or 100% of soybean meal with EECM to achieve inclusion levels of 0, 10, 20, and 30%...
January 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28176901/the-role-of-tuberculosis-in-copd
#17
Halil Ibrahim Yakar, Hakan Gunen, Erkan Pehlivan, Selma Aydogan
BACKGROUND: Influence of tuberculosis (TB) on the natural course of COPD has not been well known. This study was designed to investigate the effects of history of TB on the long-term course of COPD. METHODS: Patients hospitalized with COPD exacerbation were consecutively included (n=598). Cases were classified into two categories: those with TB history and those without. Clinical, demographic, and radiological features were meticulously recorded, and patients were followed up for hospitalizations due to exacerbation and for overall mortality...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28176185/model-microvascular-networks-can-have-many-equilibria
#18
Nathaniel J Karst, John B Geddes, Russell T Carr
We show that large microvascular networks with realistic topologies, geometries, boundary conditions, and constitutive laws can exhibit many steady-state flow configurations. This is in direct contrast to most previous studies which have assumed, implicitly or explicitly, that a given network can only possess one equilibrium state. While our techniques are general and can be applied to any network, we focus on two distinct network types that model human tissues: perturbed honeycomb networks and random networks generated from Voronoi diagrams...
February 7, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/28168706/flow-field-simulations-and-hemolysis-estimates-for-the-food-and-drug-administration-critical-path-initiative-centrifugal-blood-pump
#19
Margaret L Heck, Allen Yen, Trevor A Snyder, Edgar A O'Rear, Dimitrios V Papavassiliou
The design of blood pumps for use in ventricular assist devices, which provide life-saving circulatory support in patients with heart failure, require remarkable precision and attention to detail to replicate the functionality of the native heart. The United States Food and Drug Administration (FDA) initiated a Critical Path Initiative to standardize and facilitate the use of computational fluid dynamics in the study and development of these devices. As a part of the study, a simplified centrifugal blood pump model generated by computer-aided design was released to universities and laboratories nationwide...
February 7, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28167210/purinergic-enzymatic-activities-in-lymphocytes-and-cardiomyocytes-of-mice-acutely-infected-by-trypanosoma-cruzi-modulating-the-inflammatory-responses
#20
Guilherme M do Carmo, Pedro H Doleski, Mariângela F de Sá, Thirssa H Grando, Nathieli B Bottari, Daniela B R Leal, Lucas T Gressler, Luan C Henker, Ricardo E Mendes, Silvia G Monteiro, Aleksandro S Da Silva
The aim of this study was to evaluate the activity of purinergic enzymes in lymphocytes and cardiac tissue of mice experimentally infected by Trypanosoma cruzi. Twelve female mice were used, divided into two groups (n = 6): uninfected and infected. On day 12 post-infection (PI), the animals were anesthetized and after euthanized, and samples were collected for analyses. Infected mice showed reduction in erythrocyte counts, hematocrit and hemoglobin concentration, as well as reduced number of total leukocytes in consequence of neutrophilia (P < 0...
February 3, 2017: Experimental Parasitology
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