keyword
https://read.qxmd.com/read/38522816/targeting-rock2-improves-macromolecular-permeability-in-a-3d-fibrotic-pancreatic-cancer-microenvironment-model
#21
JOURNAL ARTICLE
Hiroyoshi Y Tanaka, Takuya Nakazawa, Takuya Miyazaki, Horacio Cabral, Atsushi Masamune, Mitsunobu R Kano
Pancreatic cancer is characterized by a densely fibrotic stroma. The fibrotic stroma hinders the intratumoral penetration of nanomedicine and diminishes therapeutic efficacy. Fibrosis is characterized by an abnormal organization of extracellular matrix (ECM) components, namely the abnormal deposition and/or orientation of collagen and fibronectin. Abnormal ECM organization is chiefly driven by pathological signaling in pancreatic stellate cells (PSCs), the main cell type involved in fibrogenesis. However, whether targeting signaling pathways involved in abnormal ECM organization improves the intratumoral penetration of nanomedicines is unknown...
March 22, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38522424/artificial-intelligence-performance-in-clinical-neurology-queries-the-chatgpt-model
#22
JOURNAL ARTICLE
Erman Altunisik, Yasemin Ekmekyapar Firat, Emine Kilicparlar Cengiz, Gulsum Bayana Comruk
INTRODUCTION: The use of artificial intelligence technology is progressively expanding and advancing in the health and biomedical literature. Since its launch, ChatGPT has rapidly gained popularity and become one of the fastest-growing artificial intelligence applications in history. This study evaluated the accuracy and comprehensiveness of ChatGPT-generated responses to medical queries in clinical neurology. METHODS: We directed 216 questions from different subspecialties to ChatGPT...
March 24, 2024: Neurological Research
https://read.qxmd.com/read/38522293/colorimetric-analysis-platform-based-on-thin-layer-chromatography-for-monitoring-gluten-cross-contamination-in-food-industry
#23
JOURNAL ARTICLE
A Martinez-Aviño, Y Moliner-Martinez, C Molins-Legua, P Campins-Falcó
Monitoring of the accidental presence of gluten (Glu), resulting from cross-contamination, is imperative in different industries, in particular food industry. The objective of this study was the development of an analytical platform utilizing thin-layer chromatography (TLC) with colorimetric read-out for making binary (yes/no) decisions on surfaces and/or point of these industries. The composition of the extractive phase was optimized with commercial products used in cleaning processing lines. Subsequently, an exploration of TLC separation and detection was undertaken...
March 15, 2024: Food Chemistry
https://read.qxmd.com/read/38521542/pathologic-response-in-resectable-non-small-cell-lung-cancer-a-systematic-literature-review-and-meta-analysis
#24
JOURNAL ARTICLE
Nathalie A Waser, Melanie Quintana, Bernd Schweikert, Jamie E Chaft, Lindsay Berry, Ahmed Adam, Lien Vo, John R Penrod, Joseph Fiore, Donald A Berry, Sarah Goring
BACKGROUND: Surrogate endpoints for overall survival (OS) in patients with resectable non-small cell lung cancer (NSCLC) receiving neoadjuvant therapy are needed to provide earlier treatment outcomes indicators and accelerate drug approval. This study's main objectives were to investigate the association between pathologic complete response (pCR), major pathologic response (MPR), event-free survival (EFS) and OS, and to determine whether treatment effects on pCR and EFS correlate with treatment effects on OS...
March 23, 2024: JNCI Cancer Spectrum
https://read.qxmd.com/read/38519372/using-a-survey-analyzing-the-current-situation-of-allergic-march-in-elementary-and-junior-high-school-students-of-oyama-and-tochigi-cities-japan
#25
JOURNAL ARTICLE
Hamid Abid, Yusuke Ando, Manabu Miyamoto, Shigemi Yoshihara
BACKGROUND: Over the past few decades, allergic diseases have become more prevalent and impact around 20% of the global population. There is clinical significance of allergic march as it places a burden on the quality of life of children and their families. OBJECTIVES: To assess the current situation of allergy conditions experienced by children attending elementary and junior high schools in Oyama and Tochigi cities, Japan. METHODS: A letter was sent to parents informing them about an opt-in online survey concerning children's allergies along with a weblink and a QR code...
March 15, 2024: Pediatrics and Neonatology
https://read.qxmd.com/read/38518076/concordance-between-daily-diary-reported-prep-intake-and-intraerythrocytic-tenofovir-diphosphate-tfv-dp-in-the-amsterdam-prep-demonstration-project
#26
JOURNAL ARTICLE
Eline S Wijstma, Vita W Jongen, Anders Boyd, Mark van den Elshout, Henry J C de Vries, Udi Davidovich, Peter L Anderson, Maria Prins, Elske Hoornenborg, Maarten F Schim van der Loeff
OBJECTIVE: We assessed the association and concordance between self-reported oral preexposure prophylaxis (PrEP) intake in a diary app and intraerythrocytic drug metabolite concentrations. DESIGN: AMPrEP was a prospective demonstration study providing daily and event-driven PrEP to MSM in Amsterdam, the Netherlands (2015-2020). METHODS: Participants could record their PrEP intake in a diary app. Dried blood spots (DBS) were taken at 6, 12, 24, and 48 months and analysed for tenofovir diphosphate (TFV-DP) and emtricitabine triphosphate (FTC-TP) concentrations...
March 21, 2024: AIDS
https://read.qxmd.com/read/38517911/the-initial-visibility-of-updated-recommendations-on-preseason-heat-safety-in-high-school-athletics-among-united-states-athletic-trainers
#27
JOURNAL ARTICLE
Zachary Yukio Kerr, Jake C Diana, William M Adams, Johna K Register-Mihalik, Aliza K Nedimyer
Updated recommendations on preseason heat safety in high school (HS) athletics ("2021 Consensus Statements") were published in April 2021. This cross-sectional survey study explored the initial roll-out of the 2021 Consensus Statements, including their visibility among United States HS athletic trainers (ATs) and perceived levels of confidence in implementing them. Recruitment occurred first, from a random selection of ATs from the Board of Certification, Inc., and second, an open invitation via social media...
2024: PloS One
https://read.qxmd.com/read/38517736/inhibition-of-connective-tissue-growth-factor-expression-in-adult-retinal-pigment-epithelial-19-cells-by-blocking-yes-associated-protein-transcriptional-coactivator-with-pdz-binding-motif-activity
#28
JOURNAL ARTICLE
Yoko Murakami, Toshiyasu Imaizumi, Kouhei Hashizume, Yu Tezuka, Yusuke Oku, Naoyuki Nishiya, Atsushi Sanbe, Daijiro Kurosaka
Purpose: To investigate the effect of yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) on connective tissue growth factor (CTGF) expression in adult retinal pigment epithelial (ARPE)-19 cells. We also studied the inhibitory effect of K-975, a new pan-transcriptional enhanced associate domain (TEAD) inhibitor, and luteolin, a plant-derived flavonoid on CTGF expression. Methods: ARPE-19 cells were transfected with either YAP or TAZ overexpression plasmid or treated with transforming growth factor (TGF)-β2 ...
March 22, 2024: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38517553/a-prognostic-model-for-overall-survival-in-recurrent-glioma-patients-treated-with-bevacizumab-containing-therapy
#29
JOURNAL ARTICLE
Shanmu Jin, Wenlin Chen, Xiaopeng Guo, Hao Xing, Huiyu Yang, Qianshu Liu, Delin Liu, Kun Zhang, Hai Wang, Yu Xia, Siying Guo, Yaning Wang, Yixin Shi, Yilin Li, Yuekun Wang, Junlin Li, Jiaming Wu, Tingyu Liang, Tian Qu, Huanzhang Li, Tianrui Yang, Yu Wang, Wenbin Ma
Predictive markers and prognostic models are useful for the individualization of cancer treatment. In this study, we sought to identify clinical and molecular factors to predict overall survival in recurrent glioma patients receiving bevacizumab-containing regimens. A cohort of 102 patients was retrospectively collected from June 2011 to January 2022 at our institution. A nomogram was generated by Cox regression and feature selection algorithms based on 19 clinicopathological and 60 molecular variables. The model's performance was internally evaluated by bootstrapping in terms of discrimination and calibration...
March 22, 2024: Discover. Oncology
https://read.qxmd.com/read/38517039/eno1-contributes-to-the-gemcitabine-resistance-of-pancreatic-cancer-through-the-yap1-signaling-pathway
#30
JOURNAL ARTICLE
Hongqin Ma, Lulu Kong, Li Liu, Yusheng Du, Xinguo Zhu, Ji Wang, Wenxing Zhao
Pancreatic cancer (PC), a leading cause of cancer-related deaths, has a 5-year survival rate of approximately 10%. α-Enolase (ENO1) is a junction channel protein involved in tumor cell apoptosis and chemoresistance. However, the role of ENO1 in PC remains unclear. The expression and prognosis of ENO1 levels were determined in PC using public databases based on The Cancer Genome Atlas (TCGA) data sets. Cell viability, half maximal inhibitory concentration (IC50), autophagy, apoptosis, and autophagy markers were examined using cell counting kit-8 (CCK-8), transmission electron microscope, flow cytometry assays, and immunoblot, respectively...
March 22, 2024: Molecular Carcinogenesis
https://read.qxmd.com/read/38516763/-retracted-interaction-of-yap1-and-mtor-promotes-bladder-cancer-progression
#31
Mingxi Xu, Meng Gu, Juan Zhou, Jun Da, Zhong Wang
Following the publication of the above article, a concerned reader drew to the Editor's attention that certain of the immunohistochemical data shown in Fig. 1C on p. 236, and immunofluorescence data featured in Figs. 2G and 5G on p. 237 and 239 respectively, were strikingly similar to data that had appeared in other articles written by different authors at different research institutes which had already been published.  In view of the fact that certain of the data in the above article had already been published at the time of the paper's submission, the Editor of International Journal of Oncology has decided that this paper should be retracted from the publication...
May 2024: International Journal of Oncology
https://read.qxmd.com/read/38515849/role-of-hippo-pathway-and-cuproptosis-related-genes-in-immune-infiltration-and-prognosis-of-skin-cutaneous-melanoma
#32
JOURNAL ARTICLE
Haozhen Lv, Lin Liu, Yuexi He, Kun Yang, Yu Fu, Yingqiu Bao
Melanoma is the most lethal type of skin cancer with an increasing incidence. Cuproptosis is the most recently identified copper-dependent form of cell death that relies on mitochondrial respiration. The hippocampal (Hippo) pathway functions as a tumor suppressor by regulating Yes-associated protein/transcriptional coactivator with PDZ-binding motif (YAP/TAZ) activity. However, its role in cuproptosis remains unknown. In addition, the correlation of cuproptosis-related genes and Hippo pathway-related genes with tumor prognosis warrants further investigation...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38515687/regulation-of-dihydroartemisinin-on-the-pathological-progression-of-laryngeal-carcinoma-through-the-periostin-yap-il-6-pathway
#33
JOURNAL ARTICLE
Xin-Yu Zhang, Rui-Cong Li, Cong Xu, Xiao-Ming Li
OBJECTIVE: Laryngeal cancer (LC) is one of the most common squamous cell carcinomas of the head and neck in clinical practice, and its incidence has been increasing in recent years, but the prognosis of the patients is not favorable. Hence, it is critical to re-understand and deeply study the causes and mechanisms of LC and explore new effective treatment methods and strategies. In this study, we analyzed the effect of Dihydroartemisinin (DHA) on the pathological progression of LC through the periostin (POSTN)/Yes-associated protein (YAP)/interleukin (IL)-6 pathway, which can provide new clinical references and guidelines...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38515673/exercise-preconditioning-inhibits-doxorubicin-induced-cardiotoxicity-via-yap-stat3-signaling
#34
JOURNAL ARTICLE
Chuan-Zhi Wang, Heng-Zhi Guo, Jing-Zhi Leng, Zhi-De Liang, Jing-Tai Wang, Li-Jie Luo, Shi-Qiang Wang, Yang Yuan
Doxorubicin (DOX) possesses strong anti-tumor effects but is limited by its irreversible cardiac toxicity. The relationship between exercise, a known enhancer of cardiovascular health, and DOX-induced cardiotoxicity has been a focus of recent research. Exercise has been suggested to mitigate DOX's cardiac harm by modulating the Yes-associated protein (YAP) and Signal transducer and activator of transcription 3 (STAT3) pathways, which are crucial in regulating cardiac cell functions and responses to damage. This study aimed to assess the protective role of exercise preconditioning against DOX-induced cardiac injury...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38513327/smoking-cessation-in-pregnant-women-a-randomized-controlled-trial-investigating-the-effectiveness-of-an-ehealth-intervention-including-heart-rate-variability-biofeedback-training
#35
JOURNAL ARTICLE
Willeke van Dijk, Mirjam Oosterman, Wieke de Vente, Imke Jansen, Matthijs Blankers, Anja C Huizink
BACKGROUND: Prenatal smoking and stress are associated with adverse health effects for women themselves and are risk factors for adverse outcomes of the child. Effective interventions are needed to support women with smoking cessation and reducing stress. The aims were (1) to test the effectiveness of an 8-week eHealth intervention targeting stress reduction and smoking cessation; (2) to examine whether stress reduction mediated the intervention effect on smoking behavior; (3) to test motivation to quit as a moderator; and (4) to investigate a dose-response effect of program usage...
March 2, 2024: Addictive Behaviors
https://read.qxmd.com/read/38512035/-yes-associated-protein-yap-promotes-invasion-and-migration-of-cutaneous-squamous-cell-carcinoma-cells-by-activating-the-pi3k-akt-pathway
#36
JOURNAL ARTICLE
Zhenling Li, Fan Yang, Xuemei Jin, Xueyan Wang, Taiqin Chen, Chunji Quan
Objective To investigate the expression of Yes-associated protein (YAP) in cutaneous squamous cell carcinoma (cSCC) and its effects on invasion and migration. Methods Immunohistochemical staining was used to detect the expression of YAP in cSCC, Bowen disease (BD), and adjacent normal tissues, and analyzed the correlation between YAP expression and clinicopathological characteristics of cSCC. A stable cell line in A431 cells with YAP gene silencing was established through lentiviral infection. Tetramethylrhodamine isothiocyanate (TRITC)-phalloidin staining was performed to analyze the distribution and number of microfilaments in A431 cells...
March 2024: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://read.qxmd.com/read/38510352/knowledge-attitudes-and-practices-of-vaccinators-about-expanded-programs-on-immunization-a-cross-sectional-study
#37
JOURNAL ARTICLE
Sunia Azhar, Laiba Rashid, Taskeen Islam, Samar Akhtar, Kathryn L Hopkins, Theresa Sommers, Aamer Ikram, Naveed Anwer, Nabeel Ahmed Maqbool, Zakir Khan, Naveed Ahmed, Hashaam Akhtar
INTRODUCTION: The periodic evaluation of knowledge, attitudes, and practices (KAP) of healthcare workers, including vaccinators, concerning expanded programs on immunization (EPI) is very crucial for a better healthcare system. This study was carried out to assess the KAP of vaccinators about the EPI, including cold storage of vaccines and their practices related to vaccine cold chain management. METHOD: A cross-sectional study was conducted from January 2022 to June 2022 among registered vaccinators in the twin cities (Islamabad and Rawalpindi) of Pakistan...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38509844/association-of-disability-status-and-type-with-binge-drinking-and-prescription-opioid-misuse-among-adults-from-a-3-state-sample
#38
JOURNAL ARTICLE
Rachel Sayko Adams, John D Corrigan, Grant A Ritter, Zoe A Pringle, Galina Zolotusky, Rachel Blayney, Sharon Reif
BACKGROUND: Research examining at-risk substance use by disability status is limited, with little investigation into differences by disability type. We investigated binge drinking and prescription opioid misuse among adults with and without disabilities, and by type of disability, to inform need for assessment and intervention within these populations. METHODS: Secondary analyses of adults who completed the disability, alcohol, and prescription opioid misuse items in the 2018 Ohio, Florida, or Nebraska Behavioral Risk Factor Surveillance System surveys (n = 28 341), the only states that included prescription opioid misuse in 2018...
March 21, 2024: Subst Use Addctn J
https://read.qxmd.com/read/38509842/jcad-deficiency-delayed-liver-regenerative-repair-through-the-hippo-yap-signalling-pathway
#39
JOURNAL ARTICLE
Li Zhang, Yong-Yu Yang, Li Xie, Yuan Zhou, Zhenxing Zhong, Jia Ding, Zhong-Hua Wang, Yu-Li Wang, Xiu-Ping Liu, Fa-Xing Yu, Jian Wu
BACKGROUND AND AIMS: Liver regeneration retardation post partial hepatectomy (PH) is a common clinical problem after liver transplantation. Identification of key regulators in liver regeneration post PH may be beneficial for clinically improving the prognosis of patients after liver transplantation. This study aimed to clarify the function of junctional protein-associated with coronary artery disease (JCAD) in liver regeneration post PH and to reveal the underlying mechanisms. METHODS: JCAD knockout (JCAD-KO), liver-specific JCAD-KO (Jcad△Hep ) mice and their control group were subjected to 70% PH...
March 2024: Clinical and Translational Medicine
https://read.qxmd.com/read/38509477/evaluating-the-clinical-utility-of-an-easily-applicable-prediction-model-of-suicide-attempts-newly-developed-and-validated-with-a-general-community-sample-of-adults
#40
JOURNAL ARTICLE
Marcel Miché, Marie-Pierre F Strippoli, Martin Preisig, Roselind Lieb
BACKGROUND: A suicide attempt (SA) is a clinically serious action. Researchers have argued that reducing long-term SA risk may be possible, provided that at-risk individuals are identified and receive adequate treatment. Algorithms may accurately identify at-risk individuals. However, the clinical utility of algorithmically estimated long-term SA risk has never been the predominant focus of any study. METHODS: The data of this report stem from CoLaus|PsyCoLaus, a prospective longitudinal study of general community adults from Lausanne, Switzerland...
March 20, 2024: BMC Psychiatry
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