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https://www.readbyqxmd.com/read/28079802/promoter-methylation-of-yes-associated-protein-yap1-gene-in-polycystic-ovary-syndrome
#1
Li-Le Jiang, Juan-Ke Xie, Jin-Quan Cui, Duo Wei, Bao-Li Yin, Ya-Nan Zhang, Yuan-Hui Chen, Xiao Han, Qian Wang, Cui-Lian Zhang
BACKGROUND: DNA methylation modification has been proved to influence the phenotype of polycystic ovary syndrome (PCOS). Genome-wide association studies (GWAS) demonstrate that yes-associated protein (YAP1) genetic sites are associated with PCOS. The study aims to detect the methylation status of YAP1 promoter in ovary granulosa cells (GCs) of PCOS patients and explore novel therapeutic targets for PCOS. METHODS: Randomized controlled trial was applied and a total of 72 women were included in the study, including 36 cases of PCOS patients and 36 cases of health controls...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28079204/quantum-ergodicity-breaking-in-semi-classical-electron-transfer-dynamics
#2
Igor Goychuk
Can the statistical properties of single-electron transfer events be correctly predicted within a common equilibrium ensemble description? This fundamental in nanoworld question of ergodic behavior is scrutinized within a very basic semi-classical curve-crossing problem. It is shown that in the limit of non-adiabatic electron transfer (weak tunneling) well-described by the Marcus-Levich-Dogonadze (MLD) rate the answer is yes. However, in the limit of the so-called solvent-controlled adiabatic electron transfer, a profound breaking of ergodicity occurs...
January 12, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28076922/evaluating-active-parental-consent-procedures-for-school-programming-addressing-the-sensitive-topic-of-suicide-prevention
#3
Christine M Wienke Totura, Krista Kutash, Christa D Labouliere, Marc S Karver
BACKGROUND: Suicide is the second leading cause of death for adolescents. Whereas school-based prevention programs are effective, obtaining active consent for youth participation in public health programming concerning sensitive topics is challenging. We explored several active consent procedures for improving participation rates. METHODS: Five active consent methods (in-person, students taking forms home, mailing, mailing preceded by primers, mailing followed by reminder calls) were compared against passive consent procedures to evaluate recruitment success, as determined by participation (proportion who responded yes) and response (proportion who returned any response) rates...
February 2017: Journal of School Health
https://www.readbyqxmd.com/read/28076850/transforming-growth-factor-beta1-suppresses-hepatocellular-carcinoma-proliferation-via-activation-of-hippo-signaling
#4
Xiaodong Zhang, Qing Fan, Yan Li, Zhaoguo Yang, Liang Yang, Zhihong Zong, Biao Wang, Xin Meng, Qin Li, Jingang Liu, Hangyu Li
In this study, we examined the expression of core proteins of the Hippo signaling pathway in hepatocellular carcinoma (HCC) cells treated with transforming growth factor-β 1(TGF-β1) and investigated the relationship between TGF-β1 and the Hippo signaling pathway, in order to better understand their roles in HCC and their potential implications for cancer therapy. We prove that the Hippo signaling pathway is involved in the TGF-β1-induced inhibition of the growth of HCC cells. Large tumor suppressor expression (LATS1) was overexpression and yes association protein 1(YAP1) translocated from the nucleus to the cytoplasm in HCC cells treated with TGF-β1...
January 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28076804/3d-protein-dynamics-in-the-cell-nucleus
#5
Anand P Singh, Rémi Galland, Megan L Finch-Edmondson, Gianluca Grenci, Jean-Baptiste Sibarita, Vincent Studer, Virgile Viasnoff, Timothy E Saunders
The three-dimensional (3D) architecture of the cell nucleus plays an important role in protein dynamics and in regulating gene expression. However, protein dynamics within the 3D nucleus are poorly understood. Here, we present, to our knowledge, a novel combination of 1) single-objective based light-sheet microscopy, 2) photoconvertible proteins, and 3) fluorescence correlation microscopy, to quantitatively measure 3D protein dynamics in the nucleus. We are able to acquire >3400 autocorrelation functions at multiple spatial positions within a nucleus, without significant photobleaching, allowing us to make reliable estimates of diffusion dynamics...
January 10, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28074228/ventilation-induced-lung-injury-exists-in-spontaneously-breathing-patients-with-acute-respiratory-failure-yes
#6
EDITORIAL
Laurent Brochard
No abstract text is available yet for this article.
January 10, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28073159/polymeric-immunoglobulin-receptor-promotes-tumor-growth-in-hepatocellular-carcinoma
#7
Xihua Yue, Jing Ai, Yang Xu, Yi Chen, Min Huang, Xinying Yang, Bo Hu, Haotian Zhang, Changxi He, Xinrong Yang, Weiguo Tang, Xia Peng, Liwei Dong, Hongyang Wang, Jia Fan, Jian Ding, Meiyu Geng
: Deregulation of the immune system is believed to contribute to cancer malignancy, which has led to recent therapeutic breakthroughs facilitating antitumor immunity. In a malignant setting, immunoglobulin receptors, which are fundamental components of the human immune system, fulfill paradoxical roles in cancer pathogenesis. This study describes a previously unrecognized pro-oncogenic function of polymeric immunoglobulin receptor (pIgR) in the promotion of cell transformation and proliferation...
January 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28071680/loss-of-tricellular-tight-junction-protein-lsr-promotes-cell-invasion-and-migration-via-upregulation-of-tead1-areg-in-human-endometrial-cancer
#8
Hiroshi Shimada, Shyuetsu Abe, Takayuki Kohno, Seiro Satohisa, Takumi Konno, Syunta Takahashi, Tsubasa Hatakeyama, Chihiro Arimoto, Takuya Kakuki, Yakuto Kaneko, Ken-Ichi Takano, Tsuyoshi Saito, Takashi Kojima
Lipolysis-stimulated lipoprotein receptor (LSR) is a unique molecule of tricellular contacts of normal and cancer cells. We investigated how the loss of LSR induced cell migration, invasion and proliferation in endometrial cancer cell line Sawano. mRNAs of amphiregulin (AREG) and TEA domain family member 1 (TEAD1) were markedly upregulated by siRNA-LSR. In endometrial cancer tissues, downregulation of LSR and upregulation of AREG were observed together with malignancy, and Yes-associated protein (YAP) was present in the nuclei...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28069521/validity-of-simplified-versus-standard-self-report-measures-of-pain-intensity-in-preschool-aged-children-undergoing-venipuncture
#9
Anthony Emmott, Nicholas West, Guohai Zhou, Dustin Dunsmuir, Carolyne J Montgomery, Gillian R Lauder, Carl L von Baeyer
: There is inadequate age-specific data to support the use of current self-report pain scales in 3- and 4-year-old children. Most preschool-aged children also lack the necessary cognitive development to use standard scales. We aimed to evaluate the validity and feasibility of two novel simplified scales (Simplified Faces Pain Scale, S-FPS; Simplified Concrete Ordinal Scale, S-COS) for preschool-aged children. These simplified scales used a two-step self-report method: children were first asked whether they have pain (yes/no); only if yes, then pain intensity was self-reported using a 3-point scale with visual aids signifying mild/moderate/severe...
January 6, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28069157/mri-detection-of-cerebral-lesions-in-post-traumatic-anisocoria-specificity-and-prognostic-significance
#10
D Woischneck, B Schmitz, T Kapapa
AIM: To identify whether increased numbers of brainstem lesions are found in the presence of a post-traumatic pupillary function disturbance and classify them anatomically. MATERIALS AND METHODS: In this study, a diagnostic magnetic resonance imaging (MRI) examination was performed within 8 days after traumatic brain injury (TBI) in patients who had been unconscious for more than 24 hours post-TBI. The Glasgow Outcome Scale was evaluated 6 months after TBI. The data obtained from 140 consecutively enrolled patients between 2005 and 2011 were analysed...
January 7, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28065575/multiparametric-analysis-of-cell-shape-demonstrates-that-%C3%AE-pix-directly-couples-yap-activation-to-extracellular-matrix-adhesion
#11
Julia E Sero, Chris Bakal
Mechanical signals from the extracellular matrix (ECM) and cellular geometry regulate the nuclear translocation of transcriptional regulators such as Yes-associated protein (YAP). Elucidating how physical signals control the activity of mechanosensitive proteins poses a technical challenge, because perturbations that affect cell shape may also affect protein localization indirectly. Here, we present an approach that mitigates confounding effects of cell-shape changes, allowing us to identify direct regulators of YAP localization...
January 2, 2017: Cell Systems
https://www.readbyqxmd.com/read/28065563/point-should-wireless-pulmonary-artery-hemodynamic-monitoring-be-used-to-monitor-patients-with-pulmonary-hypertension-yes
#12
EDITORIAL
Mark Jay Zucker
No abstract text is available yet for this article.
December 22, 2016: Chest
https://www.readbyqxmd.com/read/28064355/population-pharmacokinetic-models-of-lamotrigine-in-different-age-groups-of-chinese-children-with-epilepsy
#13
Zhong-Bin Zhang, Shuang-Min Ji, Ying Han, Li-Li Zang, Ying-Hui Wang, Wei Lu, Li Wang, Ye Wu
PURPOSE: The study aims to establish population pharmacokinetic (PPK) models of lamotrigine (LTG) in different age groups of epileptic children by nonlinear mixed effect modelling(NONMEM), and provide essential tools and theoretical basis for individualised optimal drug dose. METHODS: Cases of 473 epileptic children were divided into infant, toddler and preschool age (≤6 years) (n = 211), school age (6-12 years) (n = 171) and adolescence age (>12 years) (n = 81)...
January 7, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28061003/is-it-advisable-to-include-negative-attributes-to-assess-the-stereotype-content-yes-but-only-in-the-morality-dimension
#14
Pablo Sayans-Jiménez, Antonio José Rojas Tejada, Isabel Cuadrado Guirado
Competence, morality and sociability dimensions have shown to be essential to measure stereotypes. Theoretically, the attributes associated with the negative pole of morality are more reliable and have shown to have higher evaluative weight. However, the current research usually employs only positive attributes to measure each dimension. Since the advantages of the inclusion of negative morality are clear it would be interesting to know about the effects of the inclusion of such type of attributes (i.e., it is good or bad for the measurement)...
January 6, 2017: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/28056275/-unprotected-sexual-intercourse-and-its-correlates-within-hiv-serodiscordant-couples-in-dehong-prefecture-of-yunnan-province-china-in-2014
#15
Y C Zhang, Y F Cao, Y C Yang, R H Tang, S J Yang, L Li, S T Yao, R H Ye, J B Wang, S Duan, N He
Objective: To study the prevalence and correlates of unprotected sexual intercourse within HIV serodiscordant couples in Dehong prefecture, Yunnan Province, China, in 2014. Methods: This study was based on the follow-up investigation of "the AIDS cohort of seronegative spouses of HIV-infected individuals in Dehong prefecture" in 2014. The 1 520 participants were HIV seronegative spouses from all five counties/cities of Dehong prefecture who voluntarily participated in the cohort. Inclusion criteria included: having a HIV-positive spouse; ≥16 years of age; having had sexual intercourse with spouse in the past year; and being a resident of Dehong prefecture...
January 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28049763/the-receptor-tyrosine-kinase-axl-mediates-nuclear-translocation-of-the-epidermal-growth-factor-receptor
#16
Toni M Brand, Mari Iida, Kelsey L Corrigan, Cara M Braverman, John P Coan, Bailey G Flanigan, Andrew P Stein, Ravi Salgia, Jana Rolff, Randall J Kimple, Deric L Wheeler
The epidermal growth factor receptor (EGFR) is a therapeutic target in patients with various cancers. Unfortunately, resistance to EGFR-targeted therapeutics is common. Previous studies identified two mechanisms of resistance to the EGFR monoclonal antibody cetuximab. Nuclear translocation of EGFR bypasses the inhibitory effects of cetuximab, and the receptor tyrosine kinase AXL mediates cetuximab resistance by maintaining EGFR activation and downstream signaling. Thus, we hypothesized that AXL mediated the nuclear translocation of EGFR in the setting of cetuximab resistance...
January 3, 2017: Science Signaling
https://www.readbyqxmd.com/read/28049449/association-of-atopic-dermatitis-with-depressive-symptoms-and-suicidal-behaviors-among-adolescents-in-korea-the-2013-korean-youth-risk-behavior-survey
#17
Seulki Lee, Aesun Shin
BACKGROUND: Atopic dermatitis (AD) is a chronic skin disease which has been known to negatively influence the mental health of patients. However, only a few studies have explored the prevalence of psychiatric problems among AD patients, particularly among adolescents. In this study, we aimed to assess the association of AD with depressive symptoms and suicidal behaviors among adolescents by analyzing data from the 2013 Korean Youth Risk Behavior Survey, a nationwide web-based survey. METHODS: Data from 72,435 adolescent middle and high school students in Korea were analyzed...
January 3, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28048528/we-h-206-01-photoacoustic-tomography-multiscale-imaging-from-organelles-to-patients-by-ultrasonically-beating-the-optical-diffusion-limit
#18
L Wang
: Lihong V. Wang: Photoacoustic tomography (PAT), combining non-ionizing optical and ultrasonic waves via the photoacoustic effect, provides in vivo multiscale functional, metabolic, and molecular imaging. Broad applications include imaging of the breast, brain, skin, esophagus, colon, vascular system, and lymphatic system in humans or animals. Light offers rich contrast but does not penetrate biological tissue in straight paths as x-rays do. Consequently, high-resolution pure optical imaging (e...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047869/we-h-206-02-recent-advances-in-multi-modality-molecular-imaging-of-small-animals
#19
B Tsui
: Lihong V. Wang: Photoacoustic tomography (PAT), combining non-ionizing optical and ultrasonic waves via the photoacoustic effect, provides in vivo multiscale functional, metabolic, and molecular imaging. Broad applications include imaging of the breast, brain, skin, esophagus, colon, vascular system, and lymphatic system in humans or animals. Light offers rich contrast but does not penetrate biological tissue in straight paths as x-rays do. Consequently, high-resolution pure optical imaging (e...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047205/we-h-206-03-promises-and-challenges-of-benchtop-x-ray-fluorescence-ct-xfct-for-quantitative-in-vivo-imaging
#20
S Cho
: Lihong V. Wang: Photoacoustic tomography (PAT), combining non-ionizing optical and ultrasonic waves via the photoacoustic effect, provides in vivo multiscale functional, metabolic, and molecular imaging. Broad applications include imaging of the breast, brain, skin, esophagus, colon, vascular system, and lymphatic system in humans or animals. Light offers rich contrast but does not penetrate biological tissue in straight paths as x-rays do. Consequently, high-resolution pure optical imaging (e...
June 2016: Medical Physics
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