keyword
MENU ▼
Read by QxMD icon Read
search

yes

keyword
https://www.readbyqxmd.com/read/29149457/hmgb1-controls-liver-cancer-initiation-through-yap-dependent-aerobic-glycolysis
#1
Ruochan Chen, Shan Zhu, Xue-Gong Fan, Haichao Wang, Michael T Lotze, Herbert J Zeh, Timothy R Billiar, Rui Kang, Daolin Tang
Emerging studies have suggested that the Hippo pathway is involved in the tumorigenesis of hepatocellular carcinoma (HCC). However, the key regulator of the Hippo pathway in liver tumor metabolic reprogramming remains elusive. Here, we provide evidence to support that high mobility group box 1 (HMGB1), a chromosomal protein, plays a role in the regulation of the Hippo pathway during liver tumorigenesis. Cre/loxP recombination-mediated HMGB1 depletion in hepatocytes blocks diethylnitrosamine-induced liver cancer initiation in mice, whereas shRNA-mediated gene silencing of HMGB1 inhibits HCC cell proliferation...
November 17, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29149438/patient-predicted-sleep-position-vs-hst-data-a-tendency-to-underestimate-supine-sleep
#2
Adam J Sorscher, Anthony P Anzivino, Todd Mackenzie
PURPOSE: The purpose of this study is to measure people's accuracy when they estimate what proportion of their nightly sleep at home is supine vs. non-supine. METHODS: A series of patients referred for obstructive sleep apnea (OSA) evaluation were asked if they "knew with confidence" how they slept with regard to their body position. "Yes" responders were then asked to estimate what percentage of their sleep was supine vs. non-supine. This value was compared with the actual proportion of supine vs...
November 17, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29148421/a-validation-study-of-the-simple-psoriatic-arthritis-screening-sipas-questionnaire-to-screen-psoriasis-patients-for-psoriatic-arthritis
#3
Fausto Salaffi, Marco Di Carlo, Michele Maria Luchetti, Eleonora Di Donato, Anna Campanati, Devis Benfaremo, Massimiliano Nicolini, Marina Carotti, Alfredo Giacchetti, Giulia Ganzetti, Leonardo Bugatti, Armando Gabrielli, Anna Maria Offidani
OBJECTIVES: To validate in a multicentric cohort of patients a self-administered PsA screening tool, called Simple Psoriatic Arthritis Screening (SiPAS) questionnaire, to screen psoriasis patients for signs and symptoms of PsA. METHODS: The SiPAS questionnaire was validated in a multicentric Italian cohort of psoriasis patients referred to two rheumatological centres. RESULTS: A total of 202 psoriasis patients were screened with SiPAS in the validation study...
November 16, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29146425/unprecedented-sensitivity-of-the-planar-yeast-estrogen-screen-by-using-a-spray-on-technology
#4
Andreas Schoenborn, Pascal Schmid, Sarah Bräm, Georg Reifferscheid, Marina Ohlig, Sebastian Buchinger
The planar yeast estrogen screen (p-YES) can serve as a highly valuable and sensitive screening tool for the detection of estrogenic compounds in various sample matrices such as water and wastewater, personal care products and foodstuff. The method combines the separation of sample constituents by thin layer chromatography with the direct detection of estrogenic compounds on the surface of the HPTLC-plate. The previous protocol using the immersion of a normal phase silica HPTLC-plate in a cell suspension for bio-autography resulted in blurred signals due to the accelerated diffusion of compounds on the wet surface of the HPTLC-plate...
November 7, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29146405/point-should-segmentectomy-rather-than-lobectomy-be-the-operation-of-choice-for-early-stage-non-small-cell-lung-cancer-yes
#5
EDITORIAL
Antonio D'Andrilli, Erino Angelo Rendina
No abstract text is available yet for this article.
November 9, 2017: Chest
https://www.readbyqxmd.com/read/29143925/production-of-fumonisins-by-endophytic-strains-of-tolypocladium-cylindrosporum-and-its-relation-to-fungal-virus-infection
#6
Iñigo Zabalgogeazcoa, Amador Alvarez, Noemi Herrero, Beatriz R Vazquez-de-Aldana
Fumonisins were first discovered in Fusarium verticillioides, a fungus associated to disease and asymptomatic infections in maize. Afterwards, other fungal taxa have been found to produce fumonisins. The entomopathogenic ascomycete Tolypocladium cylindrosporum has been isolated from soil and also as an endophyte from leaves of grasses. The objectives of this work were to determine the in vitro production of fumonisin B (FB) mycotoxins and the immunosuppressive compound cyclosporine A (CyA) in several strains of T...
November 16, 2017: Mycotoxin Research
https://www.readbyqxmd.com/read/29143363/utility-of-shear-wave-elastography-for-assessing-allograft-fibrosis-in-renal-transplant-recipients-a-pilot-study
#7
Heather M Early, Ellen C Cheang, Jorge M Aguilera, Jonah S W Hirschbein, Ghaneh Fananapazir, Machelle D Wilson, John P McGahan
OBJECTIVES: To evaluate the utility of ultrasound-based shear wave elastography (SWE) as a noninvasive method to accurately detect and potentially stage the severity of renal allograft fibrosis and assess its user reproducibility. METHODS: In this Institutional Review Board-approved, Health Insurance Portability and Accountability Act-compliant prospective study, 70 renal transplant recipients underwent an SWE evaluation of their allograft followed directly by biopsy...
November 16, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29138751/expression-of-microrna-29a-regulated-by-yes-associated-protein-modulates-the-neurite-outgrowth-in-n2a-cells
#8
Chunye Tan, Changlin Yu, Zhiwen Song, Hongjun Zou, Xu Xu, Jinbo Liu
Yes-associated protein (YAP) is proved to increase miR-29a in the present study, but the relevant molecular mechanism is not clear. Also, growing evidence indicates that the high-level miR-29a promotes the neurite outgrowth by decreasing PTEN (phosphatase and tensin homologue deleted on chromosome 10). Results show that the expression of miR-29a increases but the PTEN decreases during transfecting the N2a cells with the YAP plasmid. Meanwhile, the advancement of neurite outgrowth is presented via using multiple methods to detect the expression of GAP-43 and NF-200, which have a strong association with neurite outgrowth...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29138479/yes-associated-protein-yap-promotes-tumorigenesis-in-melanoma-cells-through-stimulation-of-low-density-lipoprotein-receptor-related-protein-1-lrp1
#9
Huizi Xiong, Qian Yu, Yu Gong, Wenjuan Chen, Yunlei Tong, Yao Wang, Hui Xu, Yuling Shi
YAP is a critical protein in cancer development and can induce transformative phenotypes in mammary epithelial cells. Previous studies have provided evidence that YAP can contribute to the metastatic behavior of melanoma, since specific knockdown of YAP leads to reduced metastatic and invasive capacity in vitro. However, the mechanism by which YAP regulates the function of melanoma is unknown. Here, we identified that YAP has a positive impact on the expression of LRP1, which also plays critical roles in cancer...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29137343/prognostic-value-of-lncrnas-in-lung-carcinoma-a-meta-analysis
#10
Fan Fan, Zhengqiu Zhu, Chao Gao, Yun Liu, Baoqing Wang, Ziquan Wang, Jifeng Feng
Many different long non-coding RNAs (lncRNAs) have been reported to be abnormally expressed in lung carcinoma and may thus serve as prognostic biomarkers for this disease. We conducted this meta-analysis, which included a total of 30 studies identified via searches of PubMed, Embase, Medline, and Web of Science and included 2912 patients from China (28), Germany (1), and Japan (1), to investigate the prognostic value of different lncRNAs in lung carcinoma. The results revealed that lncRNA transcription levels were significantly associated with overall survival in lung cancer patients (HR:1...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136529/yap-dependent-axl-overexpression-mediates-resistance-to-egfr-inhibitors-in-nsclc
#11
Elena Ghiso, Cristina Migliore, Vito Ciciriello, Elena Morando, Annalisa Petrelli, Simona Corso, Emmanuele De Luca, Gaia Gatti, Marco Volante, Silvia Giordano
The Yes-associated protein (YAP) is a transcriptional co-activator upregulating genes that promote cell growth and inhibit apoptosis. The main dysregulation of the Hippo pathway in tumors is due to YAP overexpression, promoting epithelial to mesenchymal transition, cell transformation, and increased metastatic ability. Moreover, it has recently been shown that YAP plays a role in sustaining resistance to targeted therapies as well. In our work, we evaluated the role of YAP in acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in lung cancer...
November 11, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29135910/sleep-disordered-breathing-in-children-with-recurrent-wheeze-asthma-a-single-centre-study
#12
Marco Zaffanello, Emma Gasperi, Laura Tenero, Michele Piazza, Angelo Pietrobelli, Luca Sacchetto, Franco Antoniazzi, Giorgio Piacentini
The relationship between asthma and sleep-disordered breathing is bidirectional due to common risk factors that promote airway inflammation. Obstructive sleep-disordered breathing and recurrent wheeze/asthma are conditions that involve the upper and the lower respiratory system, respectively. The aim of the present study was to investigate the sleep disordered breathing in children with recurrent wheeze/asthma. This was a retrospective study concerning children older than 2 years who underwent-between January 2014 and November 2016-an in-laboratory overnight polygraphic study...
November 14, 2017: Children
https://www.readbyqxmd.com/read/29131252/yap1-up-regulation-inhibits-apoptosis-of-aortic-dissection-vascular-smooth-muscle-cells
#13
T Liu, J Xu, J-L Guo, C-Y Lin, W-M Luo, Y Yuan, H Liu, J Zhang
OBJECTIVE: Elevated apoptosis of vascular smooth muscle cell (VSMC) is correlated with the occurrence of aortic dissection (AD). Yes-associated protein 1 (YAP1) is the major effector in Hippo-YAP signal pathway, which facilitates cell proliferation and suppressing apoptosis. Several studies have been performed regarding the relationship between YAP1 and AD pathogenesis. This study established the AD rat model to investigate possible roles of YAP1 in regulating VSMC apoptosis and AD pathogenesis...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29130106/molecular-alterations-of-the-nf2-gene-in-hepatocellular-carcinoma-and-intrahepatic-cholangiocarcinoma
#14
Ning Zhang, Zhang Zhao, Jiang Long, Hai Li, Bei Zhang, Guangyong Chen, Xiaojin Li, Tingxia Lv, Wei Zhang, Xiaojuan Ou, Anjian Xu, Jian Huang
Neurofibromatosis type 2 with mutations in the neurofibromin 2 (NF2) gene, encoding the Merlin protein, is an autosomal dominant disorder characterized by enhanced cancer predisposition, particularly tumors of the central nervous system. Recent animal studies indicate that disruption of NF2/Merlin function in oval cells, which are hepatic progenitor cells, may lead to the development of primary liver cancers including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC); however, its role in human primary liver cancer remains unclear...
December 2017: Oncology Reports
https://www.readbyqxmd.com/read/29122093/association-between-phthalate-exposure-and-the-use-of-plastic-containers-in-shanghai-adults
#15
Rui Hua Dong, Han Zhang, Mei Ru Zhang, Jing Si Chen, Min Wu, Shu Guang Li, Bo Chen
OBJECTIVE: Consuming phthalates may be due to the presence of food contact materials, such as plastic containers. In this study, we investigated the association between plastic container use and phthalate exposure in 2,140 Shanghai adults. METHODS: Participants completed a questionnaire on the frequency of using plastic containers in different scenarios in the previous year (e.g., daily, weekly) and on the consumption of plastic-packaged foods in the previous three days (yes or no)...
October 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29119818/profile-of-a-national-sample-of-canadian-children-with-participation-and-activity-limitations
#16
Joshua Allan Lawson, Donna Goodridge, Donna C Rennie, Guangming Zhao, Darcy D Marciniuk
Little is known about the nature of Canadian children with participation or activity limitations. Our objective was to profile a nationally representative sample of Canadian children with report of participation or activity limitation including identifying the major medical reasons attributed to these limitations and describe their sociodemographic and functional characteristics. We used data from the Canadian 2006 Participation and Activity Limitation Survey, a post-census Statistics Canada national survey of adults and children whose everyday activities were limited because of a condition or health problem...
June 2017: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
https://www.readbyqxmd.com/read/29119694/female-urinary-incontinence-and-obesity-assessed-by-anthropometry-and-dual-energy-x-ray-absorptiometry-analysis-from-the-2008-09-korean-national-health-and-nutrition-examination-survey
#17
Yeon Won Park, Jun Ho Lee
OBJECTIVE: In the present study we evaluated the association between obesity, assessed by dual energy X-ray absorptiometry (DEXA), and urinary incontinence (UI). METHODS: The study was performed on 5792 women who had taken part in the Korean National Health and Nutrition Examination Survey. UI was deemed to be present if a woman answered "yes" to the question "Do you have current UI?". Obesity was assessed using anthropometry and DEXA. Data were analyzed using Chi-squared tests, t-tests, receiver operating characteristic curves, and logistic regression analysis...
November 9, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29115373/yap-and-taz-mediate-steroid-induced-alterations-in-the-trabecular-meshwork-cytoskeleton-in-human-trabecular-meshwork-cells
#18
Jie Peng, Hailian Wang, Xin Wang, Minghan Sun, Shaoping Deng, Yi Wang
Primary open angle glaucoma is an important type of glaucoma as it is one of the most common causes of blindness. Previous studies have demonstrated that in glaucomatous patients, the human trabecular meshwork (HTM) is markedly stiffened. The purpose of the present study was to determine the regulatory role of Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) in HTM cells. Primary HTM cells were cultured with different concentrations of dexamethasone (DEX), and the expression levels of YAP and TAZ were evaluated using reverse transcription-quantitative polymerase chain reaction and western blotting...
October 23, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29114940/access-to-palliative-care-as-public-health-priority-yes-you-heard-me-right
#19
EDITORIAL
William Rosa
No abstract text is available yet for this article.
November 2017: Public Health Nursing
https://www.readbyqxmd.com/read/29111783/would-you-say-yes-in-the-evening-time-of-day-effect-on-response-bias-in-four-types-of-working-memory-recognition-tasks
#20
Koryna Lewandowska, Barbara Wachowicz, Tadeusz Marek, Halszka Oginska, Magdalena Fafrowicz
Across a wide range of tasks, cognitive functioning is affected by circadian fluctuations. In this study, we investigated diurnal variations of working memory performance, taking into account not only hits and errors rates, but also sensitivity (d') and response bias (c) indexes (established by signal detection theory). Fifty-two healthy volunteers performed four experimental tasks twice - in the morning and in the evening (approximately 1 and 10 h after awakening). All tasks were based on Deese-Roediger-McDermott paradigm version dedicated to study working/short-term memory distortions...
November 7, 2017: Chronobiology International
keyword
keyword
19884
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"