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Acanthosis nigricans

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https://www.readbyqxmd.com/read/28225950/diabetes-mellitus-and-the-skin
#1
Adriana Lucia Mendes, Helio Amante Miot, Vidal Haddad
Several dermatoses are routinely associated with diabetes mellitus, especially in patients with chronic disease. This relationship can be easily proven in some skin disorders, but it is not so clear in others. Dermatoses such necrobiosis lipoidica, granuloma annulare, acanthosis nigricans and others are discussed in this text, with an emphasis on proven link with the diabetes or not, disease identification and treatment strategy used to control those dermatoses and diabetes.
January 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28196317/common-skin-conditions-in-children-noninfectious-rashes
#2
Brian Z Rayala, Dean S Morrell
Cutaneous adverse drug reactions are among the most common noninfectious rashes of childhood. Cutaneous adverse drug reactions are classified as morbilliform, urticarial, bullous, pustular, or psoriasiform. Atopic dermatitis is one of the most common inflammatory cutaneous eruptions, and is characterized by pruritus and flexural distribution. Emollients and topical corticosteroids are first-line therapies. Topical calcineurin inhibitors are second-line, steroid-sparing drugs for certain conditions, such as face and eyelid eczema...
February 2017: FP Essentials
https://www.readbyqxmd.com/read/28181734/molecular-mechanisms-of-insulin-resistance-in-2-cases-of-primary-insulin-receptor-defect-associated-diseases
#3
Atsumi Tsuji-Hosokawa, Kei Takasawa, Risa Nomura, Yuichi Miyakawa, Chikahiko Numakura, Atsushi Hijikata, Tsuyoshi Shirai, Yoshihiro Ogawa, Kenichi Kashimada, Tomohiro Morio
BACKGROUND: Defects of the insulin receptor gene ( INSR ) cause wide spectra of congenital insulin resistance. Monoallelic defects result in milder insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN, type A). Whereas, leprechaunism (Donahue syndrome), the most severe condition with lethality during the infantile period is caused by biallelic defects of INSR . MATERIALS AND METHODS: We detected 2 missense mutations in 2 cases of leprechaunism and IRAN, type A, and reduced mRNA expression in the leprechaunism case...
February 9, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28181399/mild-achondroplasia-hypochondroplasia-with-acanthosis-nigricans-normal-development-and-a-p-ser348cys-fgfr3-mutation
#4
Natario L Couser, Chetna K Pande, Christie M Turcott, Elaine B Spector, Arthur S Aylsworth, Cynthia M Powell
Pathogenic allelic variants in the fibroblast growth factor receptor 3 (FGFR3) gene have been associated with a number of phenotypes including achondroplasia, hypochondroplasia, thanatophoric dysplasia, Crouzon syndrome with acanthosis nigricans (Crouzonodermoskeletal syndrome), and SADDAN (severe achondroplasia with developmental delay and acanthosis nigricans). Crouzon syndrome with acanthosis nigricans is caused by the pathogenic variant c.1172C>A (p.Ala391Glu) in the FGFR3 gene. The p.Lys650Thr pathogenic variant in FGFR3 has been linked to acanthosis nigricans without significant craniofacial or skeletal abnormalities...
February 9, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28164885/a-study-of-the-association-of-acanthosis-nigricans-with-subclinical-atherosclerosis
#5
Elizabeth Guevara-Gutiérrez, Alberto Tlacuilo-Parra, Pedro Gutiérrez-Fajardo, Tania Sánchez-Tenorio, Fernando Barba-Gómez, Alejandra Miranda-Díaz
BACKGROUND: Hyperinsulinism is related to the presence of acanthosis nigricans and atherosclerosis; however, we were unable to find any study on the prevalence of atherosclerosis in acanthosis nigricans. AIMS: To evaluate the prevalence of carotid atherosclerosis and metabolic alterations in Mexican patients with acanthosis nigricans. METHODS: We carried out a cross-sectional study that included 45 patients with acanthosis nigricans, age- and gender-matched with 45 healthy participants...
March 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/28093873/diagnostic-and-management-challenges-from-childhood-puberty-through-to-transition-in-severe-insulin-resistance-due-to-insulin-receptor-mutations
#6
Christina Wei, Christine P Burren
Two Caucasian girls, both of normal weight and body mass indices, were diagnosed with type A insulin resistance (IR) in childhood. Case 1 presented with premature adrenarche aged 7 years, then by age 12 years had hirsutism, acne, acanthosis nigricans, and asymptomatic diabetes. Subsequent investigation revealed raised adiponectin (15.3 mg/L) and heterozygous p.Pro1205Leu mutation in the INSR gene encoding the insulin receptor. She experienced postprandial hypoglycaemia on metformin; acarbose was trialled and discontinued aged 16 years, as she became normoglycaemic...
January 17, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28090470/acanthosis-nigricans-as-a-clinical-predictor-of-insulin-resistance-in-obese-children
#7
Young Kwon Koh, Jae Hee Lee, Eun Young Kim, Kyung Rye Moon
PURPOSE: This study aimed to evaluate the utility of acanthosis nigricans (AN) severity as an index for predicting insulin resistance in obese children. METHODS: The subjects comprised 74 obese pediatric patients who attended the Department of Pediatrics at Chosun University Hospital between January 2013 and March 2016. Waist circumference; body mass index; blood pressure; fasting glucose and fasting insulin levels; lipid profile; aspartate transaminase, alanine transaminase, glycated hemoglobin, C-peptide, and uric acid levels; and homeostatic model assessment insulin resistance (HOMA-IR) and quantitative insulin check sensitivity index (QUICKI) scores were compared between subjects with AN and those without AN...
December 2016: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/28086952/glucagon-like-peptide-1-analogues-an-efficient-therapeutic-option-for-the-severe-insulin-resistance-of-lipodystrophic-syndromes-two-case-reports
#8
Joana Oliveira, Eva Lau, Davide Carvalho, Paula Freitas
BACKGROUND: Lipodystrophic syndromes are uncommon medical conditions which are normally associated with metabolic disorders, such as diabetes mellitus, dyslipidemia, and fatty liver disease. These complications are generally difficult to treat, particularly diabetes, due to severe insulin resistance. We present two case reports of successful treatment of diabetes with glucagon-like peptide-1 analogues in patients with clinical features of lipodystrophic syndromes. CASE PRESENTATION: Two white women aged 49 and 60 years manifested marked central body fat deposition with severe lipoatrophy of their limbs and buttocks and pronounced acanthosis nigricans...
January 13, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28081576/the-clinical-characteristics-of-obese-patients-with-acanthosis-nigricans-and-its-independent-risk-factors
#9
Yueye Huang, Jiaqi Chen, Xingchun Wang, Yan Li, Shezhen Yang, Shen Qu
Objective: This study aimed to investigate the clinical characteristics and risk factors for acanthosis nigricans (AN) in obese patients. Methods: 80 obese patients without AN (OB group) and 128 obese patients with AN (AN group) were included in this study. Clinical data for each patients were collected. Serum levels of leptin were measured by ELISA. Results: Body mass index (BMI), uric acid (UA) levels, fasting insulin, and HOMA-IR were higher in AN than OB (P<0.05). The levels of leptin were significantly higher in AN than OB (P<0...
January 12, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28059134/triglyceride-to-hdl-c-ratio-is-associated-with-insulin-resistance-in-overweight-and-obese-children
#10
Nur Ahmad Kamil Zati Iwani, Muhammad Yazid Jalaludin, Ruziana Mona Wan Mohd Zin, Md Zain Fuziah, Janet Yeow Hua Hong, Yahya Abqariyah, Abdul Halim Mokhtar, Wan Mohamud Wan Nazaimoon
The purpose of this study was to investigate the usefulness of triglyceride to hdl-c ratio (TG:HDL-C) as an insulin resistance (IR) marker for overweight and obese children. A total of 271 blood samples of obese and overweight children aged 9-16 years were analysed for fasting glucose, lipids and insulin. Children were divided into IR and non-insulin resistance, using homeostasis model assessment (HOMA). The children were then stratified by tertiles of TG: HDL-C ratio. The strength between TG:HDL-C ratio and other parameters of IR were quantified using Pearson correlation coefficient (r)...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28031780/double-diabetes-in-saudi-arabia-a-new-entity-or-an-underestimated-condition
#11
Rim Braham, Aus Alzaid, Asirvatham Alwin Robert, Muhammad Mujammami, Rania Ahmad Ahmad, Monther Zitouni, Samia Hasan Sobki, Mohamed Abdulaziz Al Dawish
AIM: To determine the clinical and biological characteristics of double diabetes (DD) among young people in Saudi Arabia. METHODS: This was a retrospective descriptive chart review study including 312 young newly diagnosed diabetic patients (aged 12-20 years), whom were admitted over a five year period (January 2009 to December 2013). Family history of diabetes mellitus (DM) (first degree), physical body mass index (BMI), acanthosis nigricans, history of auto-immune disease and laboratory information for glycosylated hemoglobin, basal C peptide level and diabetes autoantibody response (anti-GAD, anti-IA2 and anti-ICA) were collected from medical report...
December 15, 2016: World Journal of Diabetes
https://www.readbyqxmd.com/read/28031729/acanthosis-nigricans-in-obese-adolescents-prevalence-impact-and-management-challenges
#12
REVIEW
Hak Yung Ng
Obesity in adolescence is a public health priority because it usually tracks into adulthood, resulting in enormous medical and social costs. This underscores the importance of early identification and intervention. Acanthosis nigricans (AN) was once considered a rare paraneoplastic dermatosis, but is now frequently observed in obese adolescents. Current understanding suggests that it is associated with insulin resistance and has a unique role in secondary prevention. The purpose of this narrative review is to provide a comprehensive overview of AN in obese adolescents, covering its history, current knowledge on the condition, its clinical significance, management challenges, and the direction of future research...
2017: Adolescent Health, Medicine and Therapeutics
https://www.readbyqxmd.com/read/28008647/palmoplantar-keratoderma-in-costello-syndrome-responsive-to-acitretin
#13
Nareh V Marukian, Jonathan L Levinsohn, Brittany G Craiglow, Leonard M Milstone, Keith A Choate
Costello syndrome (CS) is a multisystem congenital disorder characterized by coarse facial features, cardiac defects, intellectual disability, and predisposition to malignancies. Dermatologic findings can include cutaneous papillomas, skin redundancy, acanthosis nigricans, and keratosis pilaris. Palmoplantar keratoderma (PPK) is present in approximately 76% of patients with CS, with disabling functional consequences in severe cases. We report a case of CS with severe PPK that improved dramatically with systemic administration of acitretin 0...
December 23, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/28007053/specific-skin-signs-as-a-cutaneous-marker-of-diabetes-mellitus-and-the-prediabetic-state-a-systematic-review
#14
Rewend Salman Bustan, Daanyaal Wasim, Knud Bonnet Yderstræde, Anette Bygum
INTRODUCTION: Diabetes mellitus and the prediabetic state are associated with a number of skin manifestations. This study is a systematic review of the following manifestations: acanthosis nigricans (AN), skin tags (ST), diabetic dermopathy (DD), rubeosis faciei (RF), pruritus (PR), granuloma annulare (GA), necrobiosis lipoidica (NL), scleroedema diabeticorum (SD) and bullosis diabeticorum (BD). These conditions possibly relate to underlying diabetogenic mechanisms. Our aim was to determine whether skin signs are feasible as cutaneous markers for the prediabetic or diabetic state...
January 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/27999648/comparison-of-long-pulsed-alexandrite-laser-and-topical-tretinoin-ammonium-lactate-in-axillary-acanthosis-nigricans-a-case-series-of-patients-in-a-before-after-trial
#15
Amirhoushang Ehsani, Pedram Noormohammadpour, Azadeh Goodarzi, Mostafa Mirshams Shahshahani, Seyede Pardis Hejazi, Elhamsadat Hosseini, Arghavan Azizpour
BACKGROUND: Acanthosis nigricans (AN) is a brown to black, velvety hyperpigmentation of the skin that usually involves cutaneous folds. Treatment of AN is important regarding cosmetic reasons and various therapeutic modalities have been used for these purposes. The goal of this study was to compare the effectiveness of long-pulsed alexandrite laser and topical tretinoin-ammonium lactate for treatment of axillary-AN. METHODS: Fifteen patients with bilateral axillary-AN were studied in Razi Hospital, Tehran, Iran...
2016: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/27990384/a-descriptive-study-of-facial-acanthosis-nigricans-and-its-association-with-body-mass-index-waist-circumference-and-insulin-resistance-using-homa2-ir
#16
Shyam Verma, Resham Vasani, Rajiv Joshi, Meghana Phiske, Pritesh Punjabi, Tushar Toprani
INTRODUCTION: The term facial acanthosis nigricans (FAN) lacks definition of precise clinical and histopathological features. We present a descriptive study of patients with FAN to define pigmentary patterns and estimate the prevalence of obesity and insulin resistance in these cases. MATERIALS AND METHODS: It is a prospective study that included all patients with classical AN of the neck and/or other areas with facial acanthosis nigricans described as brown-to-black macular pigmentation with blurred ill-defined margins, found on the zygomatic and malar areas...
November 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27987313/assessment-of-egf-receptor-ligand-expression-in-gastric-carcinoma-and-in-lesional-skin-of-paraneoplastic-acanthosis-nigricans-a-case-report
#17
E Moreno-Artero, E Querol, M Ivars, I Sola, R Pío, A España
A 70-year-old male presented with hyperpigmentation and thickening of the skin, especially on the neck, axillae and groin, papillomatous thickening of the mucosa of the mouth and lips which presented a "stone path-like" morphology and cutaneous and palmoplantar thickening with marked accentuation of skin dermatoglyphic patterns ("tripe-palms") (Fig 1). The lesions had started one year previously and were accompanied by generalized pruritus, intense asthenia on mild exertion and weight loss. This article is protected by copyright...
December 17, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27987249/achondroplasia-development-pathogenesis-and-therapy
#18
REVIEW
David M Ornitz, Laurence Legeai-Mallet
Autosomal dominant mutations in Fibroblast Growth Factor Receptor 3 (FGFR3) cause Achondroplasia (Ach), the most common form of dwarfism in humans, and related chondrodysplasia syndromes that include Hypochondroplasia (Hch), Severe Achondroplasia with Developmental Delay and Acanthosis Nigricans (SADDAN), and Thanatophoric dysplasia (TD). FGFR3 is expressed in chondrocytes and mature osteoblasts where it functions to regulate bone growth. Analysis of the mutations in FGFR3 revealed increased signaling through a combination of mechanisms that include stabilization of the receptor, enhanced dimerization, and enhanced tyrosine kinase activity...
December 17, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27982330/bariatric-surgery-is-it-reasonable-before-the-age-of-16
#19
Lilian Helena Polak Massabki, Letícia Esposito Sewaybricker, Keila Hayashi Nakamura, Roberto Teixeira Mendes, Antonio DE Azevedo Barros, Maria Ângela Reis DE Góes Monteiro Antonio, Mariana Porto Zambon
Objective: to assess the severity of obesity in children and adolescents through the presence of comorbidities and the potential indication of bariatric surgery. Methods: we conducted a cross-sectional study with clinical and laboratory data of the first consultation of patients at the childhood obesity clinic at a tertiary hospital from 2005 to 2013. We divided the patients into groups with or without potential indication for surgery, and recorded age, gender, birth weight, age of obesity onset, BMI Z score, presence of acanthosis nigricans, blood pressure, total cholesterol and fractions, triglycerides, blood glucose and fasting insulin, HOMA1-IR, CRP and ESR...
September 2016: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/27967300/clinical-features-and-management-of-non-hiv-related-lipodystrophy-in-children-a-systematic-review
#20
Nidhi Gupta, Noor Asi, Wigdan Farah, Jehad Almasri, Patricia Moreno Barrionuevo, Mouaz Alsawas, Zhen Wang, Morey W Haymond, Rebecca J Brown, M Hassan Murad
CONTEXT: Lipodystrophy syndromes are characterized by generalized or partial absence of adipose tissue, usually associated with insulin resistance-related conditions. OBJECTIVE: We conducted a systematic review to synthesize existing data on clinical and metabolic features of lipodystrophy (age at onset < 18 years). DATA SOURCE: Sources included Medline, Embase, Cochrane Library, Scopus and Non-Indexed Citations from inception through January 2016...
December 14, 2016: Journal of Clinical Endocrinology and Metabolism
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