keyword
MENU ▼
Read by QxMD icon Read
search

Hemochromatosis

keyword
https://www.readbyqxmd.com/read/28700532/musculoskeletal-involvement-in-hereditary-hemochromatosis
#1
Raul Castellanos-Moreira, Sebastian C Rodríguez-García, Helena Florez, Jose Inciarte-Mundo, Raimon Sanmarti
No abstract text is available yet for this article.
July 11, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28694969/hypogonadotropic-hypogonadism-in-men-with-hereditary-hemochromatosis
#2
Rabih El Osta, Nicolas Grandpre, Nicolas Monnin, Jacques Hubert, Isabelle Koscinski
Hereditary hemochromatosis is a genetic disease that progresses silently. This disease is often diagnosed late when complications appear. Hypogonadotropic hypogonadism (HH) is one of the classical complications of hemochromatosis. Its frequency is declining probably because of earlier diagnosis and better informed physicians. Certain symptoms linked to HH can have an impact on a patient's sexuality, such as decreased libido, erectile dysfunction, and impairment of ejaculation, as well as on his reproductive capacities...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/28694024/iron-metabolism-state-of-the-art
#3
R Daher, Z Karim
Iron homeostasis relies on the amount of its absorption by the intestine and its release from storage sites, the macrophages. Iron homeostasis is also dependent on the amount of iron used for the erythropoiesis. Hepcidin, which is synthesized predominantly by the liver, is the main regulator of iron metabolism. Hepcidin reduces serum iron by inhibiting the iron exporter, ferroportin expressed both tissues, the intestine and the macrophages. In addition, in the enterocytes, hepcidin inhibits the iron influx by acting on the apical transporter, DMT1...
July 7, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28684448/hemochromatosis-iron-loading-anemia-and-smad
#4
Victor R Gordeuk
No abstract text is available yet for this article.
July 6, 2017: Blood
https://www.readbyqxmd.com/read/28678636/iron-loading-in-hfe-p-c282y-homozygotes-found-by-population-screening-relationships-to-hla-type-and-t-lymphocyte-subsets
#5
Ketil Thorstensen, Mona A Kvitland, Wenche Ø Irgens, Arne Åsberg, Berit Borch-Iohnsen, Torolf Moen, Kristian Hveem
Iron loading in p.C282Y homozygous HFE hemochromatosis subjects is highly variable, and it is unclear what factors cause this variability. Finding such factors could aid in predicting which patients are at highest risk and require closest follow-up. The degree of iron loading has previously been associated with certain HLA-types and with abnormally low CD8 + cell counts in peripheral blood. In 183 Norwegian, p.C282Y homozygotes (104 men, 79 women) originally found through population screening we determined HLA type and measured total T-lymphocytes, CD4 + and CD8 + cells, and compared this with data on iron loading...
July 5, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28655414/heart-and-heart-liver-transplantation-in-patients-with-hemochromatosis
#6
Monique R Robinson, Sadeer G Al-Kindi, Guilherme H Oliveira
BACKGROUND: Hemochromatosis predisposes to dilated or restrictive cardiomyopathy which can progress to end-stage heart failure, requiring the use of advanced heart therapies including heart (HT) and heart liver (HLT) transplantation. Little is known about the characteristics and outcomes of these patients. METHODS AND RESULTS: We queried the United Network for Organ Sharing (UNOS) registry for all patients listed for HT or HLT for a diagnosis of 'hemochromatosis' between 1987 and 2014...
June 21, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28648620/iron-overload-induces-hypogonadism-in-male-mice-via-extrahypothalamic-mechanisms
#7
Chiara Macchi, Liliana Steffani, Roberto Oleari, Antonella Lettieri, Luca Valenti, Paola Dongiovanni, Antonio Romero-Ruiz, Manuel Tena-Sempere, Anna Cariboni, Paolo Magni, Massimiliano Ruscica
INTRODUCTION: Iron overload leads to multiple organ damage including endocrine organ dysfunctions. Hypogonadism is the most common non-diabetic endocrinopathy in primary and secondary iron overload syndromes. AIM: To explore the molecular determinants of iron overload-induced hypogonadism with specific focus on hypothalamic derangements. A dysmetabolic male murine model fed iron-enriched diet (IED) and cell-based models of gonadotropin-releasing hormone (GnRH) neurons were used...
June 22, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28631037/inclusion-bodies-of-aggregated-hemosiderins-in-liver-macrophages
#8
Hisao Hayashi, Yasuaki Tatsumi, Shinya Wakusawa, Ryota Shigemasa, Ryoji Koide, Ken-Ichi Tsuchida, Natsuko Morotomi, Tetsuji Yamashita, Kotaro Kumagai, Yukiya Ono, Kazuhiko Hayashi, Masatoshi Ishigami, Hidemi Goto, Ayako Kato, Koichi Kato
Hemosiderin formation is a structural indication of iron overload. We investigated further adaptations of the liver to excess iron. Five patients with livers showing iron-rich inclusions larger than 2 µm were selected from our database. The clinical features of patients and structures of the inclusions were compared with those of 2 controls with mild iron overload. All patients had severe iron overload with more than 5000 ng/mL of serum ferritin. Etiologies were variable, from hemochromatosis to iatrogenic iron overload...
June 19, 2017: Medical Molecular Morphology
https://www.readbyqxmd.com/read/28624580/proton-pump-inhibitors-decrease-phlebotomy-need-in-hfe-hemochromatosis-double-blind-randomized-placebo-controlled-trial
#9
Annick Vanclooster, Cees van Deursen, Reggy Jaspers, David Cassiman, Ger Koek
No abstract text is available yet for this article.
June 14, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28610845/hemochromatosis-and-blood-donation
#10
REVIEW
Turid Aarhus Braseth, Tor Hervig, Anne Synnove Rosvik
The voluntary, unpaid, altruistic blood donor is a cornerstone of current transfusion medicine. The complexity of medical and ethical issues related to blood donation and hemochromatosis has led to a large number of studies related to the safety of the hemochromatosis donor and the quality of the blood components produced from these donations. The issue of accepting persons with HC as blood donors is diverting, both in Europe and worldwide and without joint guidelines. A questionnaire-based study was performed and mailed to all 25 blood bank leaders in Norway...
June 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28609562/cryptogenic-cirrhosis-misunderstood-cause-of-yellow-urticaria
#11
Mariana Boechat Souza, Teresa Russo, Lilian Mathias Delorenze, Gabriela Castro, Giuseppe Argenziano, Vincenzo Piccolo
We read with great interest the paper by Combalia et al recently appeared on Journal of European Academy of Dermatology(1) . The authors reported two cases of yellow urticaria related to liver cirrhosis, one due to hemochromatosis, and the other one to alcohol(1) . With a total of ten cases reported in literature by now, we considered relevant to report another case we recently came across. This article is protected by copyright. All rights reserved.
June 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28586532/periodontal-status-and-serum-biomarker-levels-in-hfe-hemochromatosis-patients-a-case-series-study
#12
Vincent Meuric, Fabrice Lainé, Emile Boyer, Sandrine Le Gall-David, Emmanuel Oger, Denis Bourgeois, Philippe Bouchard, Edouard Bardou-Jacquet, Valérie Turmel, Martine Bonnaure-Mallet, Yves Deugnier
AIM: To investigate the association between periodontal status and serum biomarkers in patients with HFE hemochromatosis. MATERIAL AND METHODS: This clinical case series included 84 HFE-C282Y homozygous patients. Periodontal evaluation was performed using clinical attachment level, probing depth, gingival bleeding index, visible plaque index and gingival index. Serum markers of iron metabolism were collected from medical records. The relationship between serum biomarkers of iron burden and the severity of periodontitis was investigated...
June 6, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28579370/the-blood-donor-with-hemochromatosis-to-be-or-not-to-be
#13
EDITORIAL
Tor Hervig, Jerard Seghatchian
No abstract text is available yet for this article.
May 19, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28558947/hemochromatosis-protein-hfe-knockout-mice-as-a-novel-model-of-hemochromatosis-implications-for-study-and-management-of-iron-overload-cardiomyopathy
#14
EDITORIAL
Pavel Zhabyeyev, Gavin Y Oudit
No abstract text is available yet for this article.
July 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28558946/a-mouse-model-of-cardiomyopathy-induced-by-mutations-in-the-hemochromatosis-hfe-gene
#15
Haidar Djemai, Rémi Thomasson, Yvan Trzaskus, Nathalie Mougenot, Amira Meziani, Jean-François Toussaint, Philippe Noirez, Damien Vitiello
BACKGROUND: The heart is 1 of the organs most affected by hereditary hemochromatosis (HH). The clinical impact of cardiomyopathy in patients with HH requires a particular diagnosis and less invasive treatments. We developed a model of cardiomyopathy in knockout (KO) mice for the high-Fe (HFE) gene and assessed left ventricular (LV) function and structure from 7-20 months. METHODS: Male wild-type (WT) heterozygous and KO SV129 mice for the HFE gene were used in this study...
July 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28555756/design-and-chemical-syntheses-of-potent-matriptase-2-inhibitors-based-on-trypsin-inhibitor-sfti-1-isolated-from-sunflower-seeds
#16
Agata Gitlin-Domagalska, Dawid Dębowski, Anna Łęgowska, Marit Stirnberg, Joanna Okońska, Michael Gütschow, Krzysztof Rolka
Matriptase-2 plays a pivotal role in keeping iron concentrations within a narrow physiological range in humans. The opportunity to reduce matriptase-2 proteolytic activity may open a novel possibility to treat iron overload diseases, such as hereditary hemochromatosis and thalassemia. Here, we present 23 new analogues of trypsin inhibitor SFTI-1 designed to inhibit human matriptase-2. Influence of the modifications Gly1Lys, Ile10Arg and Phe12His, as well as the introduction of Narg in P1 or P1 and P4 positions were examined...
May 27, 2017: Biopolymers
https://www.readbyqxmd.com/read/28541873/an-unusual-presentation-of-seborrheic-keratoses-in-a-man-with-hereditary-hemochromatosis
#17
Tiffany Y Loh, Philip R Cohen
Hereditary hemochromatosis is an autosomal recessive disorder that disturbs iron metabolism and results in iron deposition throughout the body. Iron accumulation in various organs may cause a wide range of systemic symptoms and cutaneous manifestations of the disease are particularly striking. Classically, hereditary hemochromatosis has been termed "bronze diabetes." Although diffuse hyperpigmentation is a well-described feature of this disease, other cutaneous symptoms may also occur, and a variety of anomalies may be observed...
April 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28541437/hyperferritinemia-and-inflammation
#18
Kate Kernan, Joseph A Carcillo
Understanding of ferritin biology has traditionally centered on its role in iron storage and homeostasis, with low ferritin levels indicative of deficiency and high levels indicative of primary or secondary hemochromatosis. However, further work has shown that iron, redox biology and inflammation are inexorably linked. During infection, increased ferritin levels represent an important host defense mechanism that deprives bacterial growth of iron and protect immune cell function. It may also be protective, limiting the production of free radicals and mediating immunomodulation...
May 25, 2017: International Immunology
https://www.readbyqxmd.com/read/28540293/altered-erythropoiesis-in-mouse-models-of-type-3-hemochromatosis
#19
R M Pellegrino, F Riondato, L Ferbo, M Boero, A Palmieri, L Osella, P Pollicino, B Miniscalco, G Saglio, A Roetto
Type 3 haemochromatosis (HFE3) is a rare genetic iron overload disease which ultimately lead to compromised organs functioning. HFE3 is caused by mutations in transferrin receptor 2 (TFR2) gene that codes for two main isoforms (Tfr2α and Tfr2β). Tfr2α is one of the hepatic regulators of iron inhibitor hepcidin. Tfr2β is an intracellular isoform of the protein involved in the regulation of iron levels in reticuloendothelial cells. It has been recently demonstrated that Tfr2 is also involved in erythropoiesis...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28527894/hfe-genotype-affects-exosome-phenotype-in-cancer
#20
Oliver D Mrowczynski, A B Madhankumar, Becky Slagle-Webb, Sang Y Lee, Brad E Zacharia, James R Connor
Neuroblastoma is the third most common childhood cancer, and timely diagnosis and sensitive therapeutic monitoring remain major challenges. Tumor progression and recurrence is common with little understanding of mechanisms. A major recent focus in cancer biology is the impact of exosomes on metastatic behavior and the tumor microenvironment. Exosomes have been demonstrated to contribute to the oncogenic effect on the surrounding tumor environment and also mediate resistance to therapy. The effect of genotype on exosomal phenotype has not yet been explored...
August 2017: Biochimica et Biophysica Acta
keyword
keyword
1987
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"