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Hand and neck

Xuzhi He, Jazmina L Cruz, Shannon Joseph, Nicola Pett, Hui Yi Chew, Zewen K Tuong, Satomi Okano, Gabrielle Kelly, Margaret Veitch, Fiona Simpson, James W Wells
The Epidermal Growth Factor Receptor (EGFR) is selectively expressed on the surface of numerous tumours, such as non-small cell lung, ovarian, colorectal and head and neck carcinomas. EGFR has therefore become a target for cancer therapy. Cetuximab is a chimeric human/mouse monoclonal antibody (mAb) that binds to EGFR, where it both inhibits signaling and induces cell death by antibody-dependent cell mediated cytotoxicity (ADCC). Cetuximab has been approved for clinical use in patients with head and neck squamous cell carcinoma (HNSCC) and colorectal cancer...
February 23, 2018: Oncotarget
Wibke Uller, Sherif El-Sobky, Ahmad I Alomari, Steven J Fishman, Samantha A Spencer, Amir H Taghinia, Gulraiz Chaudry
PURPOSE: The purpose of this study was to evaluate the safety and efficacy of preoperative percutaneous n-butyl cyanoacrylate (nBCA) embolization of venous malformations in children. MATERIAL AND METHODS: Clinical data were retrospectively reviewed in children who underwent embolization using nBCA followed by resection of venous malformations. RESULTS: A total of 17 embolizations were performed in 14 patients (9 females, mean age: 5.5 years; median age: 3 years; range 0...
January 1, 2018: Vascular and Endovascular Surgery
David C Kieser, P J Cox, S C J Kieser
PURPOSE: Hirayama disease is an initially progressive disease caused by cervical neck flexion compressing the anterior horns of the lower cervical spinal cord. It is primarily seen in young males of Indian or Asian descent. With increasing dispersion of these populations this condition is increasingly being encountered internationally. This grand round reviews this rare but increasingly recognized condition. MATERIALS AND METHODS: We present a classic case of a young Indian male with progressive hand and forearm weakness...
March 14, 2018: European Spine Journal
Feng Zhao, Matthew Kirby, Anuradha Roy, Yizhong Hu, X Edward Guo, Xiaodu Wang
Understanding the relationship between the microstructure and mechanical function of trabecular bone is critical for prediction and prevention of bone fragility fractures. However, a detailed understanding of the structural design of trabecular microarchitecture is still missing. This study hypothesized that there exists a commonality in the underlying probabilistic distributions of microstructural features of trabecular bones, whereas the microstructural differences among individuals are primarily describe by a set of scalar parameters...
March 10, 2018: Bone
Damian Jacob Sendler
INTRODUCTION: Erotic asphyxiation is a sexual phenomenon in which one partner reduces the other person's brain oxygen level through strangulation. This study analyzes deaths caused by sexually-motivated strangulation to cases of homicidal choking - summarizing criminal penalties for defendants, depending on the presence of drugs, or alcohol intoxication. METHODS: The mode of analysis involves three sources of data. First, a retrospective chart review of our clinics' two recent cases...
March 10, 2018: Journal of Forensic and Legal Medicine
Saeid Abrishamkar, Sohrab Salimi, Habib Pirmoradi
Background: The standard treatment for cervical disc herniation is open discectomy surgery but some of techniques, such as nucleoplasty were applied by neurosurgeons in recent decade. The aim of this study was to compare the postoperation results of open discectomy and nucleoplasty methods in people suffering from single cervical disc herniation. Materials and Methods: In a clinical trial study that performed during 2012-2013, 70 patients who candidate for neck surgery were selected and randomly divided into two groups...
2018: Advanced Biomedical Research
Antonio Tancredi, Paolo Graziano, Lucia Dimitri, Elvira Impagnatiello, Marco Taurchini
A sclerosing perineurioma presents as a single asymptomatic papule or nodule located on the hands of adult patients; approximately 60 cases have been reported in medical literature since 1997. Histologically, it originates from the perineural cells of the peripheral nerves and presents epithelial membrane antigen (EMA) positivity and S100 protein negativity. Here, we present the case of a 58-year-old male admitted to our surgery unit complaining of left supraclavicular swelling of 1-cm in size, having no significant past medical history...
February 2018: Eurasian Journal of Medicine
Xiaohui Shen, Xia Gao, Hui Li, Yajun Gu, Junguo Wang
Laryngeal carcinoma is a kind of head and neck carcinoma with high incidence and mortality. Chemotherapy treatments ofhuman laryngeal carcinoma may fail due to the development of chemo-resistance. Tissue inhibitor of metalloproteinases 3 (TIMP3) has been shown to be implicated in a number of pathological processes typical for cancer. The present study aims to investigate the involvement of TIMP-3 in chemo-resistance of laryngeal carcinoma. We showed that TIMP3 expression was significantly decreased in chemo-resistant laryngeal carcinoma tissues compared with chemo-sensitivity tissues...
March 9, 2018: Oncology Research
Iris Veen, D Killian, L Vlaminck, J C M Vernooij, W Back
BACKGROUND: Debate surrounds the use of high rein tension for obtaining different head and neck positions in the training of sport horses on account of possible welfare issues. OBJECTIVES: To compare auxiliary rein tension in two methods for obtaining a standardized head and neck position on a hard and a soft surface; Draw Reins and Concord Leader. STUDY DESIGN: Intervention study. METHODS: Left and right rein tensions were measured in 11 base-level trained client-owned sport horses (mean age ± standard deviation: 10 ± 3...
March 8, 2018: Equine Veterinary Journal
Atessa Pakfetrat, Zohreh Dalirsani, Seyed Issac Hashemy, Ala Ghazi, Leyla Vazifeh Mostaan, Kazem Anvari, Atekeh Movaghari Pour
Background and Aim: Squamous cell carcinoma (SCC) is the most common type of oral cancer, and it is important for it to be diagnosed in early stages. Researchers are interested in exploring the possibility of using biomarkers in the diagnosis of SCC in early stages. One of the detectable biomarkers in the serum is glutathione. Glutathione includes two forms: reduced form (or GSH) and oxidized form (or GSSG). The GSH/GSSG ratio tends to decrease in severe oxidative stress. The aim of this study was to assess the serum levels of GSH and GSSG as well as GSH/GSSG as total antioxidant capacity in patients with head and neck SCC (HNSCC) and to subsequently compare them with healthy controls...
January 2018: Journal of Cancer Research and Therapeutics
Chee-Chee H Stucky, Kate D Cromwell, Rachel K Voss, Yi-Ju Chiang, Karin Woodman, Jeffrey E Lee, Janice N Cormier
Background: Many surgeons experience work-related pain and musculoskeletal symptoms; however, comprehensive reporting of surgeon ailments is lacking in the literature. We sought to evaluate surgeons' work-related symptoms, possible causes of these symptoms, and to report outcomes associated with those symptoms. Materials and methods: Five major medical indices were queried for articles published between 1980 and 2014. Included articles evaluated musculoskeletal symptoms and ergonomic outcomes in surgeons...
March 2018: Annals of Medicine and Surgery
Christian Kühnel, Thomas Winkens, Philipp Seifert, Robert Drescher, Martin Freesmeyer
To assess the radiation exposure of the investigator during navigated fusion of nuclear medicine images with ultrasound after application of I-124. Dosimetry with two different types of thermoluminescent detectors (TLD) was performed in 25 patients. The dose rate at the patient's neck was measured with a calibrated dose rate meter (DRM) and served as the standard of reference. The average exposure per investigation at the patient's neck measured by LiF:Mg,Cu,P TLDs (cumulative: 212 μSv), LiF:Mg,Ti TLDs (cumulative: 112 μSv) and DRM (cumulative: 150...
March 2, 2018: Radiation Protection Dosimetry
Witold Owczarek, Monika Słowińska, Aleksandra Lesiak, Magdalena Ciążyńska, Aldona Maciąg, Elwira Paluchowska, Luiza Marek-Józefowicz, Rafał Czajkowski
Overexpression of the epidermal growth factor receptor (EGFR) is found in many cancers, including those of the head and neck area, non-small-cell lung cancer, and colorectal, cervical, prostate, breast, ovary, stomach, and pancreatic cancer. The EGFR inhibitors are used at present in the treatment of such cancers. Skin lesions that develop during and after cancer treatment may be due to specific cytostatics, molecular-targeted drugs, radiation therapy, complementary therapy, or the cancer itself, and hence knowledge is essential to distinguish between them...
October 2017: Postȩpy Dermatologii i Alergologii
Jo-Anne Geere, Jamie Bartram, Laura Bates, Leslie Danquah, Barbara Evans, Michael B Fisher, Nora Groce, Batsirai Majuru, Michael M Mokoena, Murembiwa S Mukhola, Hung Nguyen-Viet, Phuc Pham Duc, Ashley Rhoderick Williams, Wolf-Peter Schmidt, Paul R Hunter
Background: The Sustainable Development Goals include commitments to end poverty, and promote education for all, gender equality, the availability of water and decent work for all. An important constraint is the fact that each day, many millions of women and children, and much less frequently men, carry their household's water home from off-plot sources. The burden of fetching water exacerbates gender inequality by keeping women out of education and paid employment. Despite speculation about the potential health impacts of fetching water, there is very little empirical evidence...
June 2018: Journal of Global Health
Yueh-Hsia Chen, Wei-An Liang, Chung-Yin Hsu, Siang-Lan Guo, Shwu-Huei Lien, Hsiao-Jung Tseng, Yuan-Hung Chao
Background: Advanced treatment of oral cancer increases survival rates; however, it also increases the risk of developing shoulder dysfunction, dysphagia, oral dysfunction, donor site morbidity and psychological issues. This single-arm preliminary pilot study aims to explore the effects of a six-month early intervention program following reconstructive surgery in oral cancer survivors. Methods: A total of 65 participants were analyzed following reconstructive surgery...
2018: PeerJ
Seddighi Afsoun, Seddighi Amir Saied, Nikouei Amir, Javadian Hamed
Giant cell tumors (GCTs) are rare, benign, and locally aggressive primary bone neoplasms. Spine is seldom affected, especially above the level of sacrum. In this report, we describe a case with GCT of the cervical vertebrae which causes collapse of the corpus. A 32-year-old female presented with gradual neck pain and abrupt paresthesia of the left hand. Computed tomography scan showed C6 vertebral collapse and magnetic resonance imaging demonstrated vertebral plana of C6 by a low signal intensity lesion on T1- and T2-weighted images...
January 2018: Asian Journal of Neurosurgery
Maria Isabel Bento Ayres Pereira Harry Leite, Sérgio Azevedo Ferreira Alves, Rui Paulo Vicente Reinas, Marta Gomes Rodrigues, Ana Sofia Martins das Neves Garrido, Otília Peixoto da Cunha, Joana Sofia Oliveira Rodrigues, Maria de Fátima Oliveira Santos Poças, Mário António Leite Resende Martins
A previously healthy 13-year-old girl presented with a 9-day history of acute onset severe neck pain associated with limited range of movement. Medical evaluation at day 2 was suggestive of muscle contracture, and she was discharged home with diazepam, antiinflammatory agents, and rest; however, she returned because of progressive clinical worsening with left arm distal paresthesia and paralysis since day 3. There was no history of trauma or other systemic complaints, and her familial medical history was unremarkable...
February 28, 2018: Pediatric Emergency Care
T Fukusumi, J A Califano
Comprehensive genomic analyses have been performed for head and neck squamous cell carcinoma (HNSCC), revealing a significant rate of NOTCH1 mutations and identifying NOTCH1 as the second most frequently mutated gene after TP53. Most NOTCH1 mutations are considered inactivating, indicating that NOTCH1 is a tumor suppressor gene. On the other hand, cohorts from Asian populations with HNSCC have shown activating NOTCH1 mutations. HNSCC with NOTCH1 mutations have a worse prognosis than the NOTCH1 wild-type tumors...
February 1, 2018: Journal of Dental Research
Adriana Moreira, André Carvalho, Inês Portugal, José Miguel Jesus
Dorsal pancreatic agenesis is a very rare congenital anomaly. Unilateral renal agenesis, on the other hand, is a relatively common congenital anomaly, although its etiology is not fully understood. Renal and pancreatic embryologic development appears to be nonrelated. We report a case of a 34-year-old man who was referred to our hospital for evaluation of cholestasis and microalbuminuria. Ultrasound and magnetic resonance imaging examinations showed empty right renal fossa and absence of the pancreatic neck, body, and tail...
February 2018: Radiology Case Reports
Marcelo Victor Pires de Sousa, Masayoshi Kawakubo, Cleber Ferraresi, Beatriz Kaippert, Elisabeth Mateus Yoshimura, Michael R Hamblin
Photobiomodulation (PBM) is a simple, efficient and cost-effective treatment for both acute and chronic pain. We previously showed that PBM applied to the mouse head inhibited nociception in the foot. Nevertheless, the optimum parameters, location for irradiation, duration of the effect, and the mechanisms of action remain unclear. In the present study, the pain threshold in the right hind-paw of mice was studied, after PBM (810 nm CW laser, spot size 1 cm2 or 6 cm2 , 1.2-36 J/cm2 ) applied to various anatomical locations...
February 26, 2018: Journal of Biophotonics
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