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methylation PCOS

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https://www.readbyqxmd.com/read/27889100/epigenetic-regulation-of-an-adverse-metabolic-phenotype-in-polycystic-ovary-syndrome-the-impact-of-the-leukocyte-methylation-of-ppargc1a-promoter
#1
Hongcui Zhao, Yue Zhao, Yun Ren, Min Li, Tianjie Li, Rong Li, Yang Yu, Jie Qiao
OBJECTIVE: To investigate PPARGC1A promoter methylation and mitochondria DNA (mtDNA) content in the leukocytes of women with polycystic ovary syndrome (PCOS) and analyze the relationship between these indices and metabolic risk for women with PCOS. DESIGN: Cross-sectional study. SETTING: University hospital. PATIENT(S): A total of 175 women with PCOS and 127 healthy controls. INTERVENTION(S): None...
November 23, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27426126/translational-insight-into-polycystic-ovary-syndrome-pcos-from-female-monkeys-with-pcos-like-traits
#2
David H Abbott, Jon E Levine, Daniel A Dumesic
Genetics-based studies of women with polycystic ovary syndrome (PCOS) implicate >20 PCOS risk genes that collectively account for <10% of PCOS. Clinicians now consider that either rare alleles or non-genetic, potentially epigenetic, developmental origins may contribute key pathogenic components to >90% of PCOS cases. Animal models convincingly demonstrate excess fetal testosterone exposure in females as a reliable, epigenetic, developmental origin for PCOS-like traits. In particular, nonhuman primates (NHPs) provide the most faithful emulation of PCOS-like pathophysiology, likely because of close similarities to humans in genomic, developmental, reproductive and metabolic characteristics, as well as aging...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27358825/epigenetic-modification-of-long-interspersed-elements-1-in-cumulus-cells-of-mature-and-immature-oocytes-from-patients-with-polycystic-ovary-syndrome
#3
Kamthorn Pruksananonda, Artisa Wasinarom, Wisan Sereepapong, Porntip Sirayapiwat, Prakasit Rattanatanyong, Apiwat Mutirangura
OBJECTIVE: The long interspersed elements (LINE-1, L1s) are a group of genetic elements found in large numbers in the human genome that can translate into phenotype by controlling genes. Growing evidence supports the role of epigenetic in polycystic ovary syndrome (PCOS). The purpose of this study is to evaluate the DNA methylation levels in LINE-1 in a tissue-specific manner using cumulus cells from patients with PCOS compared with normal controls. METHODS: The study included 19 patients with PCOS and 22 control patients who were undergoing controlled ovarian hyperstimulation...
June 2016: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/27192117/differential-dna-methylation-patterns-of-polycystic-ovarian-syndrome-in-whole-blood-of-chinese-women
#4
Shuxia Li, Dongyi Zhu, Hongmei Duan, Anran Ren, Dorte Glintborg, Marianne Andersen, Vibe Skov, Mads Thomassen, Torben Kruse, Qihua Tan
As a universally common endocrinopathy in women of reproductive age, the polycystic ovarian syndrome is characterized by composite clinical phenotypes reflecting the contributions of reproductive impact of ovarian dysfunction and metabolic abnormalities with widely varying symptoms resulting from interference of the genome with the environment through integrative biological mechanisms including epigenetics. We have performed a genome-wide DNA methylation analysis on polycystic ovarian syndrome and identified a substantial number of genomic sites differentially methylated in the whole blood of PCOS patients and healthy controls (52 sites, false discovery rate < 0...
May 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27056885/comprehensive-analysis-of-genome-wide-dna-methylation-across-human-polycystic-ovary-syndrome-ovary-granulosa-cell
#5
Jiawei Xu, Xiao Bao, Zhaofeng Peng, Linlin Wang, Linqing Du, Wenbin Niu, Yingpu Sun
Polycystic ovary syndrome (PCOS) affects approximately 7% of the reproductive-age women. A growing body of evidence indicated that epigenetic mechanisms contributed to the development of PCOS. The role of DNA modification in human PCOS ovary granulosa cell is still unknown in PCOS progression. Global DNA methylation and hydroxymethylation were detected between PCOS' and controls' granulosa cell. Genome-wide DNA methylation was profiled to investigate the putative function of DNA methylaiton. Selected genes expressions were analyzed between PCOS' and controls' granulosa cell...
May 10, 2016: Oncotarget
https://www.readbyqxmd.com/read/26975253/epigenetic-and-transcriptional-alterations-in-human-adipose-tissue-of-polycystic-ovary-syndrome
#6
Milana Kokosar, Anna Benrick, Alexander Perfilyev, Romina Fornes, Emma Nilsson, Manuel Maliqueo, Carl Johan Behre, Antonina Sazonova, Claes Ohlsson, Charlotte Ling, Elisabet Stener-Victorin
Genetic and epigenetic factors may predispose women to polycystic ovary syndrome (PCOS), a common heritable disorder of unclear etiology. Here we investigated differences in genome-wide gene expression and DNA methylation in adipose tissue from 64 women with PCOS and 30 controls. In total, 1720 unique genes were differentially expressed (Q < 0.05). Six out of twenty selected genes with largest expression difference (CYP1B1, GPT), genes linked to PCOS (RAB5B) or type 2 diabetes (PPARG, SVEP1), and methylation (DMAP1) were replicated in a separate case-control study...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26908643/the-loss-of-imprinted-dna-methylation-in-mouse-blastocysts-is-inflicted-to-a-similar-extent-by-in-vitro-follicle-culture-and-ovulation-induction
#7
M D Saenz-de-Juano, K Billooye, J Smitz, E Anckaert
STUDY HYPOTHESIS: Does in vitro follicle culture (IFC) have an effect on maintenance of imprinted DNA methylation in preimplantation mouse embryos? STUDY FINDING: We report similar alterations in the methylation pattern of H19 imprinted maternally expressed transcript (H19), small nuclear ribonucleoprotein polypeptide N (Snrpn) and mesoderm specific transcript (Mest) imprinted genes in mouse blastocysts obtained after ovulation induction and IFC. Furthermore, we observed no differences in the gene expression of maternal effect proteins related with imprinting maintenance between superovulated in vivo grown or IFC oocytes...
June 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/26305227/systems-genetics-reveals-the-functional-context-of-pcos-loci-and-identifies-genetic-and-molecular-mechanisms-of-disease-heterogeneity
#8
Michelle R Jones, Meredith A Brower, Ning Xu, Jinrui Cui, Emebet Mengesha, Yii-Der I Chen, Kent D Taylor, Ricardo Azziz, Mark O Goodarzi
Genome wide association studies (GWAS) have revealed 11 independent risk loci for polycystic ovary syndrome (PCOS), a common disorder in young women characterized by androgen excess and oligomenorrhea. To put these risk loci and the single nucleotide polymorphisms (SNPs) therein into functional context, we measured DNA methylation and gene expression in subcutaneous adipose tissue biopsies to identify PCOS-specific alterations. Two genes from the LHCGR region, STON1-GTF2A1L and LHCGR, were overexpressed in PCOS...
August 2015: PLoS Genetics
https://www.readbyqxmd.com/read/26185601/fetal-programming-of-polycystic-ovary-syndrome
#9
REVIEW
Esra Bahar Gur, Muammer Karadeniz, Guluzar Arzu Turan
Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects up to 6.8% of reproductive age women. Experimental research and clinical observations suggest that PCOS may originate in the very early stages of development, possibly even during intrauterine life. This suggests that PCOS is either genetically-transmitted or is due to epigenetic alterations that develop in the intrauterine microenvironment. Although familial cases support the role of genetic factors, no specific genetic pattern has been defined in PCOS...
July 10, 2015: World Journal of Diabetes
https://www.readbyqxmd.com/read/25956362/genome-wide-screen-of-ovary-specific-dna-methylation-in-polycystic-ovary-syndrome
#10
Ying-Ying Yu, Cui-Xiang Sun, Yin-Kun Liu, Yan Li, Li Wang, Wei Zhang
OBJECTIVE: To compare genome-wide DNA methylation profiles in ovary tissue from women with polycystic ovary syndrome (PCOS) and healthy controls. DESIGN: Case-control study matched for age and body mass index. SETTING: University-affiliated hospital. PATIENT(S): Ten women with PCOS who underwent ovarian drilling to induce ovulation and 10 healthy women who were undergoing laparoscopic sterilization, hysterectomy for benign conditions, diagnostic laparoscopy for pelvic pain, or oophorectomy for nonovarian indications...
July 2015: Fertility and Sterility
https://www.readbyqxmd.com/read/25823942/epigenetic-pattern-changes-in-prenatal-female-sprague-dawley-rats-following-exposure-to-androgen
#11
Yanjie Xia, Shanmei Shen, Xinlin Zhang, Zhantao Deng, Zou Xiang, Hongwei Wang, Long Yi, Qian Gao, Yong Wang
Androgen excess is generally considered to be one of the major characteristics of polycystic ovary syndrome (PCOS). Evidence from both clinical research and animal studies has revealed that this syndrome may have fetal origins, with epigenetics being proposed as the underlying mechanism. Our PCOS rat model induced by prenatal administration of 3mg testosterone from Embryonic Day (E) 16 to E19 showed polycystic ovaries, irregular oestrous cycles and endocrine disorders in adulthood. The methylation status of 16, 8 and 4 cytosine-phosphate-guanine (CpG) sites in the promoter regions of the androgen receptor (Ar), cytochrome P450 family 11, subfamily A, polypeptide 1 (Cyp11a1) and cytochrome P450, family 17, subfamily A, polypeptide 1 (Cyp17a1) genes, respectively, were measured by pyrosequencing...
March 31, 2015: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/25575948/lactonase-activity-and-status-of-paraoxonase-1-in-chinese-women-with-polycystic-ovarian-syndrome
#12
Yujin Zhang, Hongwei Liu, Jin He, Kelei Xu, Huai Bai, Ying Wang, Feng Zhang, Jinxia Zhang, Li Cheng, Ping Fan
OBJECTIVE: To study the relationship between the lactonase activities and status of paraoxonase 1 (PON1) and its association with the PON1 genetic polymorphisms in women with polycystic ovarian syndrome (PCOS). DESIGN: A case-control study. METHODS: A total of 455 PCOS patients and 441 control women were included in this study. The lactonase activities and concentrations of PON1 were assayed using 5-thiobutyl butyrolactone (TBBL) and 7-O-diethylphosphoryl-3-cyano-4-methyl-7-hydroxycoumarin (DEPCyMC) respectively...
April 2015: European Journal of Endocrinology
https://www.readbyqxmd.com/read/25150387/genome-wide-identification-of%C3%A2-aberrantly-methylated-promoters-in%C3%A2-ovarian-tissue-of-prenatally-androgenized-rats
#13
Duojia Zhang, Jing Cong, Huanhuan Shen, Qi Wu, Xiaoke Wu
OBJECTIVE: To identify aberrantly methylated candidate genes that are involved in the development of polycystic ovary syndrome (PCOS). DESIGN: Animal model. SETTING: University-affiliated laboratory. ANIMAL(S): Sprague-Dawley rats. INTERVENTION(S): The prenatally androgenized (PNA) rat model was established. Pregnant rats were treated with daily SC injections of T propionate during late gestation, and their female offspring were studied as adults...
November 2014: Fertility and Sterility
https://www.readbyqxmd.com/read/25051372/genome-wide-dna-methylation-and-gene-expression-patterns-provide-insight-into-polycystic-ovary-syndrome-development
#14
Xiu-Xia Wang, Jing-Zan Wei, Jiao Jiao, Shu-Yi Jiang, Da-Hai Yu, Da Li
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women. However, the epigenetic mechanism involved in PCOS progression remains largely unknown. Here, combining the DNA methylation profiling together with transcriptome analysis, we showed that (i) there were 7929 differentially methylated CpG sites (β > 0.1, P < 0.05) and 650 differential transcripts (fold change > 1.5, P < 0.005) in PCOS compared to normal ovaries; (ii) 54 genes were identified with methylated levels that were correlated with gene transcription in PCOS; and (iii) there were less hypermethylated sites, but many more hypomethylated sites residing in CpG islands and N_Shore in PCOS...
August 30, 2014: Oncotarget
https://www.readbyqxmd.com/read/25015958/lower-limb-veins-are-thicker-and-vascular-reactivity-is-decreased-in-a-rat-pcos-model-concomitant-vitamin-d3-treatment-partially-prevents-these-changes
#15
Szabolcs Várbíró, Levente Sára, Péter Antal, Anna Monori-Kiss, Anna-Mária Tőkés, Emil Monos, Rita Benkő, Noémi Csibi, Maria Szekeres, Robert Tarszabo, Agnes Novak, Péter Paragi, György L Nádasy
Polycystic ovary syndrome (PCOS) causes vascular damage to arteries; however, there are no data for its effect on veins. Our aim was to clarify the effects of dihydrotestosterone (DHT)-induced PCOS both on venous biomechanics and on pharmacological reactivity in a rat model and to test the possible modulatory role of vitamin D3 (vitD). PCOS was induced in female Wistar rats by DHT treatment (83 μg/day, subcutaneous pellet). After 10 wk, the venous biomechanics, norepinephrine (NE)-induced contractility, and acetylcholine-induced relaxation were tested in saphenous veins from control animals and from animals treated with DHT or DHT with vitD using pressure angiography...
September 15, 2014: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/24992182/early-embryonic-androgen-exposure-induces-transgenerational-epigenetic-and-metabolic-changes
#16
Ning Xu, Angela K Chua, Hong Jiang, Ning-Ai Liu, Mark O Goodarzi
Androgen excess is a central feature of polycystic ovary syndrome (PCOS), which affects 6% to 10% of young women. Mammals exposed to elevated androgens in utero develop PCOS-like phenotypes in adulthood, suggesting fetal origins of PCOS. We hypothesize that excess androgen exposure during early embryonic development may disturb the epigenome and disrupt metabolism in exposed and unexposed subsequent generations. Zebrafish were used to study the underlying mechanism of fetal origins. Embryos were exposed to androgens (testosterone and dihydrotestosterone) early at 26 to 56 hours post fertilization or late at 21 to 28 days post fertilization...
August 2014: Molecular Endocrinology
https://www.readbyqxmd.com/read/24963167/human-in-vitro-oocyte-maturation-is-not-associated-with-increased-imprinting-error-rates-at-lit1-snrpn-peg3-and-gtl2
#17
J Kuhtz, S Romero, M De Vos, J Smitz, T Haaf, E Anckaert
STUDY QUESTION: Does in vitro maturation (IVM) of cumulus-enclosed germinal vesicle (GV) stage oocytes retrieved from small antral follicles in minimally stimulated cycles without an ovulatory hCG dose induce imprinting errors at LIT1, SNRPN, PEG3 and GTL2 in human oocytes? SUMMARY ANSWER: There is no significant increase in imprinting mutations at LIT1, SNRPN, PEG3 and GTL2 after IVM of cumulus-enclosed GV oocytes from small antral follicles in minimally stimulated cycles without hCG priming...
September 2014: Human Reproduction
https://www.readbyqxmd.com/read/24649863/cyp19a1-promoter-methylation-in-saliva-associated-with-milestones-of-pubertal-timing-in-urban-girls
#18
Theresa Ryan Stueve, Mary S Wolff, Ashley Pajak, Susan L Teitelbaum, Jia Chen
BACKGROUND: Childhood obesity and early puberty are intermediate risk factors for later metabolic and reproductive disorders including diabetes, polycystic ovarian syndrome (PCOS), and breast cancer. Atypical methylation patterns in genes related to hormone and adipose metabolism, such as CYP19A1 (aromatase) and PPARG (peroxisome proliferator-activated receptor gamma), are associated with alterations in gene expression which may contribute to pathogenesis of these diseases. If present in early life, it is conceivable similar methylation aberrations may result in hormone perturbations that alter pubertal timing...
2014: BMC Pediatrics
https://www.readbyqxmd.com/read/24527662/hypomethylation-of-the-lh-choriogonadotropin-receptor-promoter-region-is-a-potential-mechanism-underlying-susceptibility-to-polycystic-ovary-syndrome
#19
Peng Wang, Han Zhao, Tao Li, Wei Zhang, Keliang Wu, Mei Li, Yuehong Bian, Hongbin Liu, Yunna Ning, Guangyu Li, Zi-Jiang Chen
Our previous genome-wide association study identified LH/choriogonadotropin receptor (LHCGR) as a susceptibility gene for polycystic ovary syndrome (PCOS). The objective of this study was to determine whether the genetic or epigenetic components associated with LHCGR participate in the pathogenesis of PCOS. The exons and flanking regions of LHCGR were sequenced from 192 women with PCOS, and no novel somatic mutations were identified. In addition, the methylation statuses of 6 cytosine-phosphate-guanine (CpG) sites in the promoter region of LHCGR were measured by pyrosequencing using peripheral blood cells from 85 women with PCOS and 88 control women...
April 2014: Endocrinology
https://www.readbyqxmd.com/read/24524197/resveratrol-potentiates-effects-of-simvastatin-on-inhibition-of-rat-ovarian-theca-interstitial-cells-steroidogenesis
#20
COMPARATIVE STUDY
Israel Ortega, Jesus A Villanueva, Donna H Wong, Amanda B Cress, Anna Sokalska, Scott D Stanley, Antoni J Duleba
BACKGROUND: Polycystic ovary syndrome (PCOS) is characterized by ovarian enlargement, hyperplastic theca compartment and increased androgen production due to, at least in part, excessive expression of several key genes involved in steroidogenesis. Previously, our group has demonstrated that simvastatin, competitive inhibitor of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase), a rate-limiting step of the mevalonate pathway, reduces rat-theca interstitial cell steroidogenesis by inhibiting Cyp17a1 gene expression, the key enzyme of the androgen biosynthesis pathway...
February 13, 2014: Journal of Ovarian Research
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