Elisabet Stener-Victorin, Gustaw Eriksson, Man Mohan Shrestha, Valentina Rodriguez Paris, Haojiang Lu, Jasmine Banks, Manisha Samad, Charlène Perian, Baptiste Jude, Viktor Engman, Roberto Boi, Emma Nilsson, Charlotte Ling, Jenny Nyström, Ingrid Wernstedt Asterholm, Nigel Turner, Johanna Lanner, Anna Benrick
BACKGROUND: Polycystic ovary syndrome's (PCOS) main feature is hyperandrogenism, which is linked to a higher risk of metabolic disorders. Gene expression analyses in adipose tissue and skeletal muscle reveal dysregulated metabolic pathways in women with PCOS, but these differences do not necessarily lead to changes in protein levels and biological function. METHODS: To advance our understanding of the molecular alterations in PCOS, we performed global proteomic and phosphorylation site analysis using tandem mass spectrometry, and analyzed gene expression and methylation...
January 5, 2024: ELife