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https://www.readbyqxmd.com/read/29767696/clinical-outcomes-related-to-the-gastrointestinal-trophic-effects-of-erythropoietin-in-preterm-neonates-a-systematic-review-and-meta-analysis
#1
Anitha Ananthan, Haribalakrishna Balasubramanian, Shripada Rao, Sanjay Patole
Erythropoietin (EPO) plays an important role in the development and maturation of the gastrointestinal tract. Recombinant EPO (rEPO) has been used to prevent anemia of prematurity. The gastrointestinal trophic effects of EPO may reduce feeding intolerance and necrotizing enterocolitis (NEC) in preterm neonates. The aim of this systematic review of randomized controlled trials (RCTs) was to evaluate the effects of rEPO on clinical outcomes such as feeding intolerance, stage II or higher NEC, any stage NEC, sepsis, retinopathy of prematurity, and bronchopulmonary dysplasia in preterm neonates...
May 1, 2018: Advances in Nutrition
https://www.readbyqxmd.com/read/29763853/text-mining-and-network-analysis-to-find-functional-associations-of-genes-in-high-altitude-diseases
#2
Balu Bhasuran, Devika Subramanian, Jeyakumar Natarajan
BACKGROUND AND OBJECTIVES: Travel to elevations above 2500 m is associated with the risk of developing one or more forms of acute altitude illness such as acute mountain sickness (AMS), high altitude cerebral edema (HACE) or high altitude pulmonary edema (HAPE). Our work aims to identify the functional association of genes involved in high altitude diseases. METHOD: In this work we identified the gene networks responsible for high altitude diseases by using the principle of gene co-occurrence statistics from literature and network analysis...
May 2, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29761823/erythropoietin-promotes-network-formation-of-transplanted-adipose-tissue-derived-microvascular-fragments
#3
P Karschnia, C Scheuer, A Heß, T Später, M D Menger, M W Laschke
The seeding of tissue constructs with adipose tissue-derived microvascular fragments (ad-MVF) is an emerging pre-vascularisation strategy. Ad-MVF rapidly reassemble into new microvascular networks after in vivo implantation. Herein it was analysed whether this process was improved by erythropoietin (EPO). Ad-MVF were isolated from green fluorescent protein (GFP)+ as well as wild-type C57BL/6 mice and cultivated for 24 h in medium supplemented with EPO (20 IU/mL) or vehicle. Freshly isolated, non-cultivated ad-MVF served as controls...
May 9, 2018: European Cells & Materials
https://www.readbyqxmd.com/read/29754961/hematopoietic-stem-cells-but-not-multipotent-progenitors-drive-erythropoiesis-during-chronic-erythroid-stress-in-epo-transgenic-mice
#4
Rashim Pal Singh, Tatyana Grinenko, Beáta Ramasz, Kristin Franke, Mathias Lesche, Andreas Dahl, Max Gassmann, Triantafyllos Chavakis, Ian Henry, Ben Wielockx
The hematopoietic stem cell (HSC) compartment consists of a small pool of cells capable of replenishing all blood cells. Although it is established that the hematopoietic system is assembled as a hierarchical organization under steady-state conditions, emerging evidence suggests that distinct differentiation pathways may exist in response to acute stress. However, it remains unclear how different hematopoietic stem and progenitor cell subpopulations behave under sustained chronic stress. Here, by using adult transgenic mice overexpressing erythropoietin (EPO; Tg6) and a combination of in vivo, in vitro, and deep-sequencing approaches, we found that HSCs respond differentially to chronic erythroid stress compared with their closely related multipotent progenitors (MPPs)...
May 4, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29754581/the-clinical-characteristics-and-therapy-response-of-patients-with-acquired-pure-red-cell-aplasia
#5
Rong Fu, Tian Zhang, Bingnan Liu, Jia Song, Guojin Wang, Lijuan Li, Huaquan Wang, Limin Xing, Yuhong Wu, Jing Guan, Zonghong Shao
OBJECTIVE: To summarize the clinical characteristics of acquired pure red cell aplasia (PRCA) patients diagnosed in our hospital in the last 10 years. METHOD: The clinical features, immune state and treatment response of acquired PRCA patients diagnosed in our hospital from January 2007 to January 2017 were retrospectively analyzed. RESULTS: The results showed that thymoma (13.21%) and parvovirus B19 (11.32%) were the most common causes for secondary PRCA...
May 12, 2018: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29752300/intramyocardial-angiogenetic-stem-cells-and-epicardial-erythropoietin-save-the-acute-ischemic-heart
#6
Christian Klopsch, Anna Skorska, Marion Ludwig, Heiko Lemcke, Gabriela Maass, Ralf Gaebel, Martin Beyer, Cornelia Lux, Anita Toelk, Karina Müller, Christian Maschmeier, Sarah Rohde, Petra Mela, Brigitte Müller-Hilke, Stefan Jockenhoevel, Brigitte Vollmar, Robert Jaster, Robert David, Gustav Steinhoff
Ischemic heart failure still displays the highest mortality. An early boost of intracardiac regenerative key mechanisms and angiogenetic niche signaling in cardiac mesenchymal stem cells (MSCs) could improve myocardial infarction (MI) healing. Epicardial erythropoietin (EPO, 300U kg-1 ) was compared with intraperitoneal and intramyocardial EPO treatments after acute MI in rats (n=156). Real-time PCR and confocal microscopy revealed epicardial EPO treatment enhanced intracardiac regenerative key indicators (SDF-1, CXCR-4, CD34, Bcl-2, Cyclin D1, Cdc2, MMP2), induced TGF-β/WNT signaling in intramyocardial MSC niches through direct activation of AKT, upregulations of upstream signals FOS and Fzd7 and augmented intracardiac mesenchymal proliferation 24 hours after MI...
May 10, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29748743/erythropoietin-and-nrf2-key-factors-in-the-neuroprotection-provided-by-apo-lactoferrin
#7
E T Zakharova, A V Sokolov, N N Pavlichenko, V A Kostevich, I N Abdurasulova, A V Chechushkov, I V Voynova, A Yu Elizarova, N N Kolmakov, M G Bass, I V Semak, A I Budevich, P M Kozhin, N K Zenkov, V M Klimenko, O V Kirik, D E Korzhevskii, E B Menshchikova, V B Vasilyev
Among the properties of lactoferrin (LF) are bactericidal, antianemic, immunomodulatory, antitumour, antiphlogistic effects. Previously we demonstrated its capacity to stabilize in vivo HIF-1-alpha and HIF-2-alpha, which are redox-sensitive multiaimed transcription factors. Various tissues of animals receiving recombinant human LF (rhLF) responded by expressing the HIF-1-alpha target genes, hence such proteins as erythropoietin (EPO), ceruloplasmin, etc. were synthesized in noticeable amounts. Among organs in which EPO synthesis occurred were brain, heart, spleen, liver, kidneys and lungs...
May 10, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29746307/erythropoietin-mimetic-peptides-and-erythropoietin-fusion-proteins-for-treating-anemia-of-chronic-kidney-disease
#8
Nupur Gupta, Jay B Wish
PURPOSE OF REVIEW: First generation erythropoiesis stimulating agents (ESAs) have short duration of action which requires administration once weekly or greater. Second generation ESAs were developed which have longer duration of action and can be administered one to two times monthly. Erythropoietin (EPO) mimetic peptides (EMPs) activate the EPO receptor but have no structural analogy to EPO, offering the potential for lower cost as they are not biologic drugs. The first approved EMP, peginesatide, was withdrawn from the market within a year of its approval because of fatal anaphylactic reactions...
May 4, 2018: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29746306/source-and-microenvironmental-regulation-of-erythropoietin-in-the-kidney
#9
Karen A Nolan, Roland H Wenger
PURPOSE OF REVIEW: Historically, the identity of O2-sensing renal erythropoietin (Epo)-producing (REP) cells was a matter of debate. This review summarizes how recent breakthroughs in transgenic mouse and in-situ hybridization techniques have facilitated sensitive and specific detection of REP cells and accelerated advancements in the understanding of the regulation of renal Epo production in health and disease. RECENT FINDINGS: REP cells are a dynamically regulated unique subpopulation of tubulointerstitial cells with features of fibroblasts, pericytes and neurons...
May 8, 2018: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29745864/modulation-of-the-expression-of-genes-related-to-the-system-of-amyloid-beta-metabolism-in-the-brain-as-a-novel-mechanism-of-ceftriaxone-neuroprotective-properties
#10
Maria A Tikhonova, Tamara G Amstislavskaya, Victor M Belichenko, Larisa A Fedoseeva, Sergey P Kovalenko, Ekaterina E Pisareva, Alla S Avdeeva, Nataliya G Kolosova, Nikolai D Belyaev, Lyubomir I Aftanas
BACKGROUND: The dominant hypothesis about the pathogenesis of Alzheimer's disease (AD) is the "amyloid cascade" concept and modulating the expression of proteins involved in the metabolism of amyloid-beta (Aβ) is proposed as an effective strategy for the prevention and therapy of AD. Recently, we found that an antibiotic ceftriaxone (CEF), which possesses neuroprotective activity, reduced cognitive deficits and neurodegenerative changes in OXYS rats, a model of sporadic AD...
April 19, 2018: BMC Neuroscience
https://www.readbyqxmd.com/read/29741264/genetic-basis-of-congenital-erythrocytosis
#11
REVIEW
C Bento
INTRODUCTION: Congenital Erythrocytosis (CE) represents a rare and heterogeneous clinical entity. It is caused by deregulated erythropoiesis where red blood cell overproduction results in elevated hemoglobin and hematocrit levels. CE may either be primary or secondary to elevated erythropoietin concentrations. The only known form of primary CE is caused by mutations in the EPOR gene. Secondary CE can be a consequence of tissue hypoxia, being caused by congenital defects such as hemoglobin variants with increased oxygen affinity, due to mutations in the α- or β-globin genes (HBB, HBA2, HBA1), or due to mutations in the BPGM gene...
May 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29740059/inhibition-of-poly-lacnac-biosynthesis-with-release-of-cmp-neu5ac-feedback-inhibition-increases-the-sialylation-of-recombinant-epo-produced-in-cho-cells
#12
Chung-Geun Lee, Myung Jin Oh, Seung-Yeol Park, Hyun Joo An, Jung Hoe Kim
Sialylation of recombinant therapeutic glycoproteins modulates their pharmacokinetic properties by affecting their in vivo half-life. N-glycan branching on glycoproteins increases the number of potential attachment sites for sialic acid. Here, we introduce a new approach for increasing the sialylation of recombinant human erythropoietin (rhEPO) produced in CHO cells by modulating poly-N-acetyllactosamine (poly-LacNAc) biosynthesis. We did not observe an increase in rhEPO sialylation, however, until the feedback inhibition by intracellular cytidine monophosphate-N-acetylneuraminic acid (CMP-Neu5Ac), which is a limiting factor for sialylation, was released...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29739123/erythropoietin-protects-erythrocytes-against-oxidative-stress-induced-eryptosis-in-vitro
#13
Yun Sun, Gang Liu, Yali Jiang, Hui Wang, Hecun Xiao, Guangju Guan
BACKGROUND: Excessive eryptosis has been found in maintained hemodialysis or peritoneal dialysis patients. Signaling of triggering eryptosis includes oxidative stress, increased cytosolic Ca2+-activity, and ceramide. Erythropoietin (EPO) possesses the property of an antioxidant. The aim of this study was to investigate the ability of hydrogen peroxide (H2O2) on erythrocytes in vitro, and to assess the possible effects of recombinant human erythropoietin (rhEPO) on eryptosis. METHODS: One percent erythrocyte suspension was cultured in vitro in three kinds of media: Control group (Group C), H2O2 group (Group H), and EPO group (Group E)...
March 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29738538/the-hypoxia-inducible-factor-erythropoietin-epo-epo-receptor-pathway-is-disturbed-in-a-rat-model-of-chronic-kidney-disease-related-anemia
#14
Daniel Landau, Lital London, Inbar Bandach, Yael Segev
OBJECTIVES: Anemia is a known driver for hypoxia inducible factor (HIF) which leads to increased renal erythropoietin (EPO) synthesis. Bone marrow (BM) EPO receptor (EPOR) signals are transduced through a JAK2-STAT5 pathway. The origins of anemia of chronic kidney disease (CKD) are multifactorial, including impairment of both renal EPO synthesis as well as intestinal iron absorption. We investigated the HIF- EPO- EPOR axis in kidney, BM and proximal tibia in anemic juvenile CKD rats. METHODS: CKD was induced by 5/6 nephrectomy in young (20 days old) male Sprague-Dawley rats while C group was sham operated...
2018: PloS One
https://www.readbyqxmd.com/read/29737525/cytomegalovirus-an-unlikely-ally-in-the-fight-against-blood-cancers
#15
Austin B Bigley, Forrest L Baker, Richard J Simpson
CMV infection is a potentially fatal complication in patients receiving HSCT, but recent evidence indicates that CMV has strong anti-leukemia effects due in part to shifts in the composition of NK-cell subsets. NK-cells are the primary mediators of the anti-leukemia effect of allogeneic HSCT and infusion of allogeneic NK-cells has shown promise as a means of inducing remission and preventing relapse of several different hematologic malignancies. The effectiveness of these treatments is limited, however, when tumors express HLA-E, a ligand for the inhibitory receptor NKG2A which is expressed by the vast majority of post-transplant reconstituted and ex vivo expanded NK-cells...
May 8, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29735438/-erythropoietin-accelerates-the-proliferation-of-glioma-cells-via-activating-akt-pathway
#16
Zi-Li Liu, Zhao-Hua Tang, Gang Huo, Fei-Lan Chen, Wen-Tao Wang, Wen-Xin Zeng, Hong Chen, Xin Li, Chen Chen
OBJECTIVE: To determine whether erythropoietin (EPO) promotes rapid proliferation of glioma through Akt pathway. METHODS: We detected the expression of EPO in human glioma tissues using immunohistochemistry. A nude mouse model bearing human glioma U87 cell xenograft was established and given intraperitoneal injection of EPO or saline every other day, and the tumor growth was observed. In the in vitro experiment, U87 cells were treated with PBS (control), EPO, or EPO with Akt inhibitor, and the expression of p-Akt and cyclin D1 was detected using Western blotting; the cell proliferation rate was determined using cell counting kit-8 and clone formation assay, and the cell cycle changes were analyzed with flow cytometry...
April 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29731355/the-erythropoietin-promoter-variant-rs1617640-is-not-associated-with-severe-retinopathy-of-prematurity-independent-of-treatment-with-erythropoietin
#17
Christof Dame, Lina K Sciesielski, Carolin Rau, Chiara-Aiyleen Badur, Christoph Bührer
In this case-control study, the erythropoietin (EPO) promoter variant s1617640, linked to high intravitreal EPO concentrations and increased risk of diabetic retinopathy, was not associated with severe retinopathy of prematurity. This finding was observed both in infants with and without recombinant EPO administration.
May 3, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29729414/semi-mechanistic-pharmacokinetic-pharmacodynamic-model-of-three-pegylated-rhuepo-and-ior%C3%A2-epocim-in-new-zealand-rabbits
#18
G Reynaldo-Fernández, J Solozábal, D Amaro, E M Fernández-Sánchez, L Rodríguez-Vera, M Bermejo, V Mangas-Sanjuan, I F Troconiz
Marketed formulations of erythropoietin (EPO) ior®EPOCIM, MIRCERA® and two newly developed pegylated-EPO analogues (PEG-EPO 32 and 40 kDa) formulations were intravenously administered to New Zealand rabbits. A semi-mechanistic Pharmacokinetic/Pharmacodynamic (PK/PD) model describing in a simultaneous and integrated form the time course of reticulocytes, red blood cells and hemoglobin was built to account for the time course of hematopoiesis stimulation after erythropoietin administration. Data analysis was performed based on the population approach with the software NONMEM version 7...
May 2, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29720275/different-effects-of-granulocyte-colony-stimulating-factor-and-erythropoietin-on-erythropoiesis
#19
Tzu-Lin Chen, Ya-Wen Chiang, Guan-Ling Lin, Hsin-Hou Chang, Te-Sheng Lien, Min-Hua Sheh, Der-Shan Sun
BACKGROUND: Red blood cells are the most abundant cells in the blood that deliver oxygen to the whole body. Erythropoietin (EPO), a positive regulator of erythropoiesis, is currently the major treatment for chronic anemia. Granulocyte colony-stimulating factor (G-CSF) is a multifunctional cytokine and a well-known regulator of hematopoietic stem cell proliferation, differentiation, and mobilization. The use of EPO in combination with G-CSF has been reported to synergistically improve erythroid responses in a group of patients with myelodysplastic syndromes who did not respond to EPO treatment alone; however, the mechanism remains unclear...
May 2, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29712435/prolyl-hydroxylase-inhibitors-a-breakthrough-in-the-therapy-of-anemia-associated-with-chronic-diseases
#20
Amit Arvind Joharapurkar, Vrajesh Bhaskarbhai Pandya, Vishal J Patel, Ranjit C Desai, Mukul R Jain
Chronic kidney disease, cancer, chronic inflammatory disorders, nutritional and genetic deficiency can cause anemia. Hypoxia causes induction of hypoxia-inducible factor (HIF), which stimulates erythropoietin (EPO) synthesis. Prolyl hydroxylase domain (PHD) enzyme inhibition can stabilize hypoxia-inducible factor (HIF). HIF stabilization also decreases hepcidin, a hormone of hepatic origin, which regulates iron homeostasis. PHD inhibitors represent the novel pharmacological treatment of anemia of chronic diseases...
May 1, 2018: Journal of Medicinal Chemistry
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