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https://www.readbyqxmd.com/read/29041034/inhaled-versus-systemic-corticosteroids-for-preventing-bronchopulmonary-dysplasia-in-ventilated-very-low-birth-weight-preterm-neonates
#1
REVIEW
Sachin S Shah, Arne Ohlsson, Henry L Halliday, Vibhuti S Shah
BACKGROUND: Bronchopulmonary dysplasia (BPD) remains an important cause of mortality and morbidity in preterm infants and inflammation plays a significant role in its pathogenesis. The use of inhaled corticosteroids may modulate the inflammatory process without concomitant high systemic steroid concentrations and less risk of adverse effects. This is an update of a review published in 2012 (Shah 2012). We recently updated the related review on "Inhaled versus systemic corticosteroids for treating bronchopulmonary dysplasia in ventilated very low birth weight preterm neonates"...
October 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29041005/cardiogenic-shock-during-first-infusion-of-anthracycline-chemotherapy-in-a-patient-with-hodgkin-lymphoma-an-unusual-event
#2
Giulio Binaghi, Damiana Congia, Stefano Cossa, Stefania Massidda, Daniele Pasqualucci, Federica Pilo, Emanuela Serra, Emanuele Angelucci, Maurizio Porcu
INTRODUCTION: Hodgkin lymphoma (HL) is one of the most common types of cancers of the lymphatic system. The currently available therapies enable a cure in approximately 80-85% of treated patients. However, the cardiotoxicity of HL treatment has become a major cause of morbidity and mortality in survivors mainly related to the use of anthracycline. CASE REPORT: An HL, staged IIIB, was diagnosed in a 60-year-old man with no cardiovascular disease. During the first cycle of ABVD chemotherapy (Adriamycin; bleomycin; vinblastine; dacarbazine), near the end of the dacarbazine infusion, the patient presented a sudden cardiogenic shock characterized by a severe left ventricular systolic dysfunction...
October 18, 2017: Cardiology
https://www.readbyqxmd.com/read/29040943/liquid-chromatography-tandem-mass-spectrometry-direct-injection-analysis-of-organophosphorus-flame-retardants-in-ontario-surface-water-and-wastewater-effluent
#3
Chunyan Hao, Paul A Helm, David Morse, Eric J Reiner
Organophosphorus flame retardants (OPFRs) started to be used in plastics, electronics and furnishings back in the 1960s and became popular again last decade. They are now widely present in the environment and regarded as "new" emerging organic pollutants. An effective liquid chromatography-tandem mass spectrometry (LC-MS/MS) direct injection analysis (DIA) method was developed to monitor OPFR levels in aquatic environment. The removal of sample extraction and concentration steps not only improved operation efficiency, but also reduced the potential contamination commonly observed during the sample preparation process before...
October 10, 2017: Chemosphere
https://www.readbyqxmd.com/read/29040620/fitness-of-mass-reared-males-of-anastrepha-obliqua-diptera-tephritidae-resulting-from-mating-competition-tests-in-field-cages
#4
Emilio Hernández, Pablo Liedo, Jorge Toledo, Pablo Montoya, Hugo Perales, Lorena Ruiz-Montoya
The sterile insect technique uses males that have been mass-reared in a controlled environment. The insects, once released in the field, must compete to mate. However, the mass-rearing condition supposes a loss of fitness that will be noticeable by wild females. To compare the fitness of wild males and mass-reared males, three competition settings were established. In setting 1, wild males, mass-reared males and wild females were released in field cages. In setting 2, wild females and wild males were released without competition, and in setting 3, mass-reared males and mass-reared females were also released without competition...
October 11, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29040570/cumulative-live-birth-rates-following-miscarriage-in-an-initial-complete-cycle-of-ivf-a-retrospective-cohort-study-of-112-549-women
#5
Natalie J Cameron, Siladitya Bhattacharya, Sohinee Bhattacharya, David J McLernon
STUDY QUESTION: In women undergoing IVF/ICSI who miscarry in their first complete cycle, what is the chance of a live birth in subsequent complete cycles, and how does this compare with those whose first complete cycle ends with live birth or without a pregnancy? SUMMARY ANSWER: After two further complete cycles of IVF/ICSI, women who had miscarried or had a live birth in their first complete cycle had a higher chance of live birth (40.9 and 49.0%, respectively) than those who had no pregnancies (30...
September 20, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040516/integrated-mental-health-services-in-china-challenges-and-planning-for-the-future
#6
Di Liang, Vickie M Mays, Wei-Chin Hwang
Eager to build an integrated community-based mental health system, in 2004 China started the '686 Programme', whose purpose was to integrate hospital and community services for patients with serious mental illness. In 2015, the National Mental Health Working Plan (2015-2020) proposed an ambitious strategy for implementing this project. The goal of this review is to assess potential opportunities for and barriers to successful implementation of a community-based mental health system that integrates hospital and community mental health services into the general healthcare system...
October 13, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29040352/preoperative-respiratory-physiotherapy-in-abdominoplasty-patients
#7
Maria Amélia Rodrigues, Lydia Masako Ferreira, Eliziane Nitz de Carvalho Calvi, Fábio Xerfan Nahas
Background: After abdominoplasty, patients experience decreased ventilatory function and increased intra-abdominal pressure (IAP). Breathing exercises are used during the pre- and postoperative periods of several abdominal surgeries to prevent or minimize postoperative complications. Objectives: The aim of this study was to assess the effect of preoperative respiratory physiotherapy on the outcome of abdominoplasty patients. Methods: Thirty-three patients were divided into 2 groups...
June 28, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29040115/keratitis-after-post-kala-azar-dermal-leishmaniasis
#8
Aditya Pradhan, Samar Basak, Tuhin Chowdhury, Ayan Mohanta, Ananya Chatterjee
PURPOSE: To report 2 cases of keratitis occurring after post-kala-azar dermal leishmaniasis (PKDL) in immunocompetent patients. METHODS: Case report and literature review. RESULTS: Two male patients presented with a dense stromal infiltrate in the temporal and superior aspects of the cornea, respectively. Microbiological workup in both patients did not show any offending organism. Both patients were undergoing treatment for PKDL in the form of oral miltefosine...
October 13, 2017: Cornea
https://www.readbyqxmd.com/read/29040067/early-onset-severe-obesity-due-to-complete-deletion-of-the-leptin-gene-in-a-boy
#9
Elif Ozsu, Serdar Ceylaner, Huseyin Onay
BACKGROUND: Monogenic obesity results from single gene mutations. Extreme obesity starting at an early age, especially in infancy, which is associated with endocrinopathy and metabolic disturbances is key to the diagnosis of monogenic obesity. CASE PRESENTATION: A 6-month-old boy was admitted to our clinic with severe obesity and food craving. He was born with a birth weight of 3400 g to first-cousin parents. He started to gain weight at an abnormal rate at the age of 2 months...
October 17, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29040056/an-integrated-control-strategy-takes-clonorchis-sinensis-under-control-in-an-endemic-area-in-south-china
#10
Yalan Huang, Dana Huang, Yijie Geng, Shisong Fang, Fan Yang, Chunli Wu, Hailong Zhang, Miao Wang, Ran Zhang, Xin Wang, Shuang Wu, Jianping Cao, Renli Zhang
Clonorchis sinensis is an important foodborne zoonosis worldwide and prevalent in China for more than 2000 years. According to the experience of controlling Schistosoma japonica, China started to establish the integrated control strategy for C. sinensis in endemic areas. Lou village, the largest village in Shenzhen city in South China was taken as a pilot site. This longitudinal study assessed the infection status of C. sinensis among people and intermediate hosts from 2006 to 2014 in Lou village. After a continuous intervention with the integrated control strategy, the prevalence of C...
October 17, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29036911/comparison-of-heavy-duty-scuffing-behavior-between-chromium-based-ceramic-composite-and-nickel-chromium-molybdenum-coated-ring-sliding-against-cast-iron-liner-under-starvation
#11
Yan Shen, Baihong Yu, Yutao Lv, Bin Li
A running-in and starved lubrication experiment is designed to investigate the heavy-duty scuffing behavior of piston ring coatings against cast iron (Fe) cylinder liner using the piston ring reciprocating liner test rig. The scuffing resistance of the piston ring with the chromium-based ceramic composite coating (CKS), and that with the thermally sprayed nickel-chromium-molybdenum coating (NCM) is compared at different nominal pressures (40~100 MPa) and temperatures (180~250 °C). With the failure time as a criterion, the rank order is as follows: NCM/Fe > CKS/Fe...
October 14, 2017: Materials
https://www.readbyqxmd.com/read/29036757/a-case-of-medullary-infarction-presented-initial-symptoms-similar-to-meniere-s-disease
#12
Jang Hee Park, Dong Hyun Kim, Jae Moon Sung, Chang Woo Kim
Fluctuating hearing loss and vertigo are the typical presentations of Meniere's disease. However, it is unusual that fluctuating hearing loss and vertigo are caused by vertebral artery occlusion or cerebral infarction. Here, we described the case of a 54-year-old male patient with hypertension and diabetes mellitus who presented with fluctuating hearing loss in his left ear and severe whirling-type dizziness without associated neurological signs or symptoms. Temporal magnetic resonance imaging (MRI) was normal...
October 17, 2017: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/29036734/benefit-cost-analysis-of-radiocesium-decorporation-by-a-prussian-blue-treatment-and-stockpiling
#13
Alexis Rump, Daniela Stricklin, Andreas Lamkowski, Stefan Eder, Matthias Port
In the case of an attack by a "dirty bomb" with cesium-137 there is a risk of internal contamination. The excretion of cesium-137 can be enhanced by Prussian Blue (PB), and thus the committed effective dose be reduced. We analyzed the benefit and costs of PB decorporation treatment. We simulated the reduction of the radiological dose by PB treatment after cesium-137 incorporation by inhalation. The saving of life time was quantified using the monetary "value of a statistical life" (VSL). Treatment costs were based on the market price of PB in Germany...
October 16, 2017: Drug Research
https://www.readbyqxmd.com/read/29036675/indoor-radon-thoron-and-their-progeny-concentrations-in-high-thoron-rural-serbia-environments
#14
Zora S Zunic, Z Stojanovska, N Veselinovic, R Mishra, I V Yarmoshenko, B K Sapra, T Ishikawa, Y Omori, Z Curguz, P Bossew, V Udovicic, R C Ramola
This article deals with the variation of radon (Rn), thoron (Tn) and their progeny concentrations expressed in terms of equilibrium equivalent concentrations (EERC and EETC), in 40 houses, in four villages of Sokobanja municipality, Southern Serbia. Two types of passive detectors were used: (1) discriminative radon-thoron detector for simultaneous Rn and Tn gases measurements and (2) direct Tn and Rn progeny sensors (DRPS/DTPS) for measuring Rn and Tn progeny concentrations. Detectors were exposed simultaneously for a single period of 12 months...
September 19, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29036640/toxicokinetics-of-the-synthetic-cathinone-%C3%AE-pyrrolidinohexanophenone
#15
Yuji Fujita, Toshinori Mita, Kiyotaka Usui, Yoshito Kamijo, Satoshi Kikuchi, Makoto Onodera, Yasuhisa Fujino, Yoshihiro Inoue
Synthetic cathinones inhibit monoamine transporters, such as serotonin, norepinephrine, and dopamine transporters, and act on the central nervous system via increasing synaptic concentrations of monoamines. These compounds, which are highly addictive and potentially poisonous, are new psychoactive substances. In this study, we investigated the toxicokinetics of the synthetic cathinone, α-pyrrolidinohexanophenone (α-PHP), and assessed the relationship between the toxicokinetics and the long-term clinical symptoms induced by α-PHP in a male patient...
September 28, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29036457/feasibility-evaluation-of-long-term-use-of-beta-blockers-and-calcium-antagonists-in-patients-with-brugada-syndrome
#16
Tsukasa Kamakura, Mitsuru Wada, Kohei Ishibashi, Yuko Y Inoue, Koji Miyamoto, Hideo Okamura, Satoshi Nagase, Takashi Noda, Takeshi Aiba, Satoshi Yasuda, Wataru Shimizu, Shiro Kamakura, Kengo Kusano
Aims: Beta-blockers (BBs) and calcium antagonists (CAs) are reported to aggravate ST-segment elevation in some patients with Brugada syndrome (BrS). The feasibility of their long-term use in BrS still remains unknown. We investigated the safety of long-term use of BB and CA in BrS patients. Methods and results: Of the 360 consecutive BrS patients, 29 [5: a history of ventricular fibrillation (VF), 17: syncope, 7: asymptomatic] took BB and/or CA (BB: 22, CA: 8) for more than 1 year for the treatment of co-morbidities such as atrial tachyarrhythmia, vasospastic angina, and neurally mediated syncope...
September 23, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29036330/adding-experimental-arms-to-platform-clinical-trials-randomization-procedures-and-interim-analyses
#17
Steffen Ventz, Matteo Cellamare, Giovanni Parmigiani, Lorenzo Trippa
Multi-arm clinical trials use a single control arm to evaluate multiple experimental treatments. In most cases this feature makes multi-arm studies considerably more efficient than two-arm studies. A bottleneck for implementation of a multi-arm trial is the requirement that all experimental treatments have to be available at the enrollment of the first patient. New drugs are rarely at the same stage of development. These limitations motivate our study of statistical methods for adding new experimental arms after a clinical trial has started enrolling patients...
July 17, 2017: Biostatistics
https://www.readbyqxmd.com/read/29035801/systematic-review-with-meta-analysis-performance-of-dried-blood-spots-for-hepatitis-c%C3%A2-antibodies-detection
#18
REVIEW
B A Muzembo, N C Mbendi, S F Nakayama
OBJECTIVES: Dried blood spots (DBS) specimens can be used for hepatitis C virus (HCV) infection screening in cases where serum specimens are difficult to obtain. However, uncertainties surround the sensitivity and specificity of DBS for HCV antibodies (anti-HCV) serology testing. We aimed to evaluate the accuracy of DBS use to screen for HCV infection. STUDY DESIGN: We carried out a systematic review and meta-analysis. METHODS: Medline and EMBASE databases were searched for articles published between 1989 and November 2016...
October 13, 2017: Public Health
https://www.readbyqxmd.com/read/29035589/the-activity-of-nintedanib-in-an-animal-model-of-allogenic-left-lung-transplantation-resembling-aspects-of-allograft-rejection
#19
Marietta von Suesskind-Schwendi, Elke Boxhammer, Stephan W Hirt, Stephan Schreml, Christof Schmid, Lutz Wollin, Karla Lehle
AIM OF THE STUDY: The prevention and treatment of chronic lung allograft dysfunction (CLAD) after lung transplantation (LTx) remain unsatisfactory. Growth factors may play an important role in the development of CLAD. This study evaluated the effects of nintedanib, a receptor tyrosine kinase inhibitor, in the treatment of CLAD after experimental LTx. MATERIALS AND METHODS: A rat model of left lung allo-transplantation (Fisher 344 to Wistar Kyoto) was used to evaluate the effect of nintedanib (50 mg/kg per day) on the development of CLAD...
October 16, 2017: Experimental Lung Research
https://www.readbyqxmd.com/read/29035425/inhaled-versus-systemic-corticosteroids-for-the-treatment-of-bronchopulmonary-dysplasia-in-ventilated-very-low-birth-weight-preterm-infants
#20
REVIEW
Sachin S Shah, Arne Ohlsson, Henry L Halliday, Vibhuti S Shah
BACKGROUND: This is an update of a review published in 2012. A related review "Inhaled versus systemic corticosteroids for preventing bronchopulmonary dysplasia in ventilated very low birth weight preterm neonates" has been updated as well. Bronchopulmonary dysplasia (BPD) is a serious and common problem among very low birth weight infants, despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome. Due to their anti-inflammatory properties, corticosteroids have been widely used to treat or prevent BPD...
October 16, 2017: Cochrane Database of Systematic Reviews
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