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https://www.readbyqxmd.com/read/28217363/crystal-structures-of-n-2-n-3-n-5-n-6-tetra-kis-pyridin-2-ylmeth-yl-pyrazine-2-3-5-6-tetra-carboxamide-and-n-2-n-3-n-5-n-6-tetra-kis-pyridin-4-ylmeth-yl-pyrazine-2-3-5-6-tetra-carboxamide
#1
Dilovan S Cati, Helen Stoeckli-Evans
The title compounds, C32H28N10O4· unknown solvent, (I), and C32H28N10O4, (II), are pyrazine-2,3,5,6-tetra-carboxamide derivatives. In (I), the substituents are (pyridin-2-ylmeth-yl)carboxamide, while in (II), the substituents are (pyridin-4-ylmeth-yl)carboxamide. Both compounds crystallize in the monoclinic space group P21/n, with Z' = 1 for (I), and Z' = 0.5 for (II). The whole mol-ecule of (II) is generated by inversion symmetry, the pyrazine ring being situated about a center of inversion. In (I), the four pyridine rings are inclined to the pyrazine ring by 83...
February 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28215900/lack-of-early-improvement-with-antipsychotics-is-a-marker-for-subsequent-nonresponse-in-behavioral-and-psychological-symptoms-of-dementia-analysis-of-catie-ad-data
#2
Kazunari Yoshida, Rachel Roberts, Takefumi Suzuki, Barry Lebowitz, Suzanne Reeves, Robert Howard, Takayuki Abe, Masaru Mimura, Hiroyuki Uchida
OBJECTIVE: Prediction of response or nonresponse to antipsychotics is especially important in patients with behavioral and psychological symptoms of dementia (BPSD) in whom antipsychotic exposure increases risks of death. This study examined whether the presence or absence of early improvement of BPSD with antipsychotics is associated with subsequent response or nonresponse. METHODS: In a post-hoc analysis of the Clinical Antipsychotic Trials of Intervention Effectiveness-Alzheimer's Disease (CATIE-AD) study (2001-2004) (clinicaltrials...
January 30, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28215872/detection-of-specific-antibodies-in-cats-infected-with-the-lung-nematode-aelurostrongylus-abstrusus
#3
Eva-Maria Zottler, Christina Strube, Manuela Schnyder
Feline aelurostrongylosis, caused by the metastrongylid nematode Aelurostrongylus abstrusus, is an underestimated respiratory parasitosis. Its diagnosis currently mainly relies on the isolation of first stage larvae from fresh faecal samples. The aim of our study was to develop a serological test for the detection of specific antibodies against A. abstrusus by ELISA. We used recombinant major sperm protein (MSP) of the bovine lungworm Dictyocaulus viviparus as detection antigen and evaluated two different ELISA plates (Maxisorp and Immobilizer™ Amino-plate, Nunc Roskilde, Denmark) with two different enzyme systems [alkaline phosphatase (AP) and horseradish peroxidase (HRP)]...
February 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28212400/surveys-of-public-knowledge-and-attitudes-with-regard-to-antibiotics-in-poland-did-the-european-antibiotic-awareness-day-campaigns-change-attitudes
#4
Beata Mazińska, Izabela Strużycka, Waleria Hryniewicz
BACKGROUND: Antimicrobial resistance is a global public health problem. Monitoring the level of knowledge regarding antibiotics is a part of the European Union Community strategy against antimicrobial resistance. OBJECTIVE: To assess knowledge by the general public in Poland regarding antibiotics, AMR, and the impact of the European Antibiotic Awareness Day campaigns. METHODS: The repeated cross-sectional study was developed and carried out among the general public in Poland (in 5 waves between 2009 and 2011, embracing a total of 5004 respondents)...
2017: PloS One
https://www.readbyqxmd.com/read/28179217/latino-adults-perspectives-on-treating-tobacco-use-via-social-media
#5
Beatriz Anguiano, Cati Brown-Johnson, Lisa G Rosas, Cornelia Pechmann, Judith J Prochaska
BACKGROUND: Latinos are the largest minority group in the United States, and in California they outnumber non-Hispanic whites. Smoking cessation programs tailored for Latino culture, and this population's specific smoking patterns, are needed. Online social networks for smoking cessation have high potential for Latinos, but have not been tested to date. OBJECTIVE: Building a research program on social media apps for cancer prevention in diverse populations, this qualitative study assessed acceptability of tobacco treatment that was distributed via social media for Latino smokers...
February 8, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28169880/blood-pressure-reduction-in-acute-ischemic-stroke-according-to-time-to-treatment-a-subgroup-analysis-of-the-china-antihypertensive-trial-in-acute-ischemic-stroke-trial
#6
Tan Xu, Yonghong Zhang, Xiaoqing Bu, Dali Wang, Yingxian Sun, Chung-Shiuan Chen, Jinchao Wang, Hao Peng, Zhong Ju, Yanbo Peng, Tian Xu, Qunwei Li, Deqin Geng, Jintao Zhang, Dong Li, Fengshan Zhang, Libing Guo, Xuemei Wang, Yong Cui, Yongqiu Li, Dihui Ma, Dongsheng Zhang, Guang Yang, Yanjun Gao, Xiaodong Yuan, Jing Chen, Jiang He
OBJECTIVE: The optimal time to initiate antihypertensive therapy among patients with acute ischemic stroke remains uncertain. We tested the effects of blood pressure reduction among patients with acute ischemic stroke according to time from onset to initiation of antihypertensive treatment. METHODS: We randomly assigned 4071 acute ischemic stroke patients with elevated SBP to receive antihypertensive treatment or to discontinue all antihypertensive medications during hospitalization...
February 6, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28157623/toxocariasis-of-the-central-nervous-system-with-report-of-two-cases
#7
Bouthouri Abir, Mansour Malek, Mrissa Ridha
Toxocariasis is a parasitic infection caused by the roundworms Toxocara canis or Toxocara cati, mostly due to accidental ingestion of embryonated eggs. Clinical manifestations vary and are classified according to the organs affected. Central nervous system involvement is an unusual complication. Here, we report two cases with neurological manifestations, in which there was cerebrospinal fluid (CSF) eosinophilia with marked blood eosinophilia and a positive serology for Toxocara both in serum and CSF. Improvement of signs and symptoms after specific treatment was observed in the two cases...
January 27, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28150892/dissociated-patterns-of-anti-correlations-with-dorsal-and-ventral-default-mode-networks-at-rest
#8
Jingyuan E Chen, Gary H Glover, Michael D Greicius, Catie Chang
Previous studies of resting state functional connectivity have demonstrated that the default-mode network (DMN) is negatively correlated with a set of brain regions commonly activated during goal-directed tasks. However, the location and extent of anti-correlations are inconsistent across different studies, which has been posited to result largely from differences in whether or not global signal regression (GSR) was applied as a pre-processing step. Notably, coordinates of seed regions-of-interest defined within the posterior cingulate cortex (PCC)/precuneus, an area often employed to study functional connectivity of the DMN, have been inconsistent across studies...
February 2, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28141958/genetic-analysis-of-toxocara-cati-nematoda-ascarididae-from-guangdong-province-subtropical-china
#9
Xi He, Meng-Na Lv, Guo-Hua Liu, Rui-Qing Lin
Toxocara cati (cat roundworm) is a common parasitic nematode that infects humans and other hosts, causing toxocariasis. Although its significance as a pathogen, the epidemiology, genetics and biology of T. cati remain poorly understand in China. In the present study, genetic variation in mitochondrial (mt) cytochrome c oxidase subunit 1 (cox1) gene and internal transcribed spacer (ITS) of rDNA region among T. cati in Guangdong province, subtropical China was examined. A portion of the cox1 (pcox1) and the complete ITS (ITS1 + 5...
January 31, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/28141857/intestinal-parasites-and-vector-borne-pathogens-in-stray-and-free-roaming-cats-living-in-continental-and-insular-greece
#10
Anastasia Diakou, Angela Di Cesare, Paolo Matteo Accettura, Luciano Barros, Raffaella Iorio, Barbara Paoletti, Antonio Frangipane di Regalbono, Lénaïg Halos, Frederic Beugnet, Donato Traversa
This survey investigated the distribution of various intestinal parasites and vector-borne pathogens in stray and free-roaming cats living in four regions of Greece. A total number of one hundred and fifty cats living in three Islands (Crete, Mykonos and Skopelos) and in Athens municipality was established as a realistic aim to be accomplished in the study areas. All cats were examined with different microscopic, serological and molecular assays aiming at evaluating the occurrence of intestinal parasites, and exposure to or presence of vector-borne infections...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28139827/application-and-bioactive-properties-of-cati-a-trypsin-inhibitor-from-capsicum-annuum-seeds-membrane-permeabilization-oxidative-stress-and-intracellular-target-in-phytopathogenic-fungi-cells
#11
Marciele S Silva, Suzanna F F Ribeiro, Gabriel B Taveira, Rosana Rodrigues, Katia V S Fernandes, André O Carvalho, Ilka Maria Vasconcelos, Erica Oliveira Mello, Valdirene M Gomes
BACKGROUND: During the last few years, a growing number of antimicrobial peptides have been isolated from plants and particularly from seeds. Recent results from our laboratory have shown the purification of a new trypsin inhibitor, named CaTI, from chilli pepper (Capsicum annuum L.) seeds. This study aims to evaluate the antifungal activity and mechanism of action of CaTI on phytopathogenic fungi and detect the presence of protease inhibitors in other species of this genus. RESULTS: Our results show that CaTI can inhibit the growth of the phytopathogenic fungi Colletotrichum gloeosporioides and C...
January 31, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28128783/link-between-haste-and-occupational-injury
#12
Simo Salminen, Pia Perttula, Maria Hirvonen, Merja Perkiö-Mäkelä, Maarit Vartia
BACKGROUND: It is claimed that haste has increased in modern work life. Only a few studies on professional drivers show that haste increases the risk of occupational injury. OBJECTIVE: The aim of this study was to examine the relationship between haste and occupational injury in a large, representative sample of Finnish employees. METHODS: The material comes from the Finnish National Work and Health, which have been carried every three years since 1977...
2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28115180/occurrence-and-clinical-significance-of-aelurostrongylus-abstrusus-and-other-endoparasites-in-danish-cats
#13
Alice P Hansen, Line K Skarbye, Lene M Vinther, Jakob L Willesen, Christian B Pipper, Caroline S Olsen, Helena Mejer
Feline endoparasites are highly prevalent worldwide and may cause a variety of clinical signs in infected cats. Prevalence rates are dynamic and there is limited knowledge of the current prevalence in Denmark and the clinical manifestation and significance of especially the lungworm Aelurostrongylus abstrusus. This study investigated the total and local prevalence of Aelurostrongylus abstrusus and other endoparasites in Danish cats. The clinical significance of feline aelurostrongylosis was also examined through identification of frequency and severity of selected clinical signs...
January 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28115175/distribution-and-dynamics-of-soil-contamination-with-toxocara-canis-and-toxocara-cati-eggs-in-poland-and-prevention-measures-proposed-after-20-years-of-study
#14
Hanna Mizgajska-Wiktor, Wojciech Jarosz, Renata Fogt-Wyrwas, Agnieszka Drzewiecka
The studies conducted in the years 1994-2013 allowed to determine the distribution of Toxocara spp. eggs in the soil of different types of urban and rural areas in Poland and to establish seasonal and multi-year dynamics of soil contamination with T. cati and T. canis eggs. Out of 3309 soil samples examined, 14.9% contained the eggs and the average density was 3.43 eggs/100g of soil. The level of soil contamination was the highest in cities, lower in villages, and lowest in small towns. In urban areas eggs of T...
January 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28104175/adapting-global-health-aid-in-the-face-of-climate-change
#15
Vin Gupta, Alexandre Mason-Sharma, Stephanie N Caty, Vanessa Kerry
No abstract text is available yet for this article.
February 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28103948/the-cost-effectiveness-of-a-patient-tailored-intervention-programme-to-enhance-adherence-to-antihypertensive-medication-in-community-pharmacies-study-protocol-of-a-randomised-controlled-trial
#16
Danielle M van der Laan, Petra J M Elders, Christel C L M Boons, Judith E Bosmans, Giel Nijpels, Jacqueline G Hugtenburg
BACKGROUND: Medication non-adherence is a complex health care problem. Due to non-adherence, substantial numbers of cardiovascular patients benefit from their medication to only a limited extent. In order to improve adherence, a variety of pharmacist-led interventions have been developed. However, even the most effective interventions achieved only a modest positive effect. To be effective, interventions should be targeted at underlying barriers to adherence, developed in a systematic manner and tailored to specific features of a target group and setting...
January 19, 2017: Trials
https://www.readbyqxmd.com/read/28100688/the-use-of-oxytocin-to-improve-feeding-and-social-skills-in-infants-with-prader-willi-syndrome
#17
Maïthé Tauber, Kader Boulanouar, Gwenaelle Diene, Sophie Çabal-Berthoumieu, Virginie Ehlinger, Pascale Fichaux-Bourin, Catherine Molinas, Sandy Faye, Marion Valette, Jeanne Pourrinet, Catie Cessans, Sylvie Viaux-Sauvelon, Céline Bascoul, Antoine Guedeney, Patric Delhanty, Vincent Geenen, Henri Martens, Françoise Muscatelli, David Cohen, Angèle Consoli, Pierre Payoux, Catherine Arnaud, Jean-Pierre Salles
BACKGROUND AND OBJECTIVES: Patients with Prader-Willi syndrome (PWS) display poor feeding and social skills as infants and fewer hypothalamic oxytocin (OXT)-producing neurons were documented in adults. Animal data demonstrated that early treatment with OXT restores sucking after birth. Our aim is to reproduce these data in infants with PWS. METHODS: We conducted a phase 2 escalating dose study of a short course (7 days) of intranasal OXT administration. We enrolled 18 infants with PWS under 6 months old (6 infants in each step) who received 4 IU of OXT either every other day, daily, or twice daily...
January 18, 2017: Pediatrics
https://www.readbyqxmd.com/read/28096863/seroepidemiological-study-of-toxocariasis-in-the-owners-of-domestic-cats-and-dogs-in-mashhad-northeastern-iran
#18
Fariba Berenji, Ali Pouryousef, Abdolmajid Fata, Mahmoud Mahmoudi, Maryam Salehi, Javad Khoshnegah
BACKGROUND: Toxocariasis is the clinical terms applied to infection of human with Ascarid nematodes in the order Ascaridida, named Toxocara canis and T. cati. Because in recent years in Iran many people desire to keep pets (cats and dogs), and lacking of seroepidemiological study of toxocariasis in Mashhad, we decided to determine the seroprevalence of toxocariasis among people who own cats and dogs in comparison with control group. METHODS: A serological study for detection antibodies to Toxocara in two groups (93 cat and dog owners and 93 healthy people as control group) was conducted from Feb 2013 to Dec 2013...
April 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28096624/genetic-variability-and-discrimination-of-low-doses-of-toxocara-spp-from-public-areas-soil-inferred-by-loop-mediated-isothermal-amplification-assay-as-a-field-friendly-molecular-tool
#19
Maryam Ozlati, Adel Spotin, Abbas Shahbazi, Mahmoud Mahami-Oskouei, Teimour Hazratian, Mohammad Adibpor, Ehsan Ahmadpour, Afsaneh Dolatkhah, Paria Khoshakhlagh
ABSTRACT: Aim: One of the main diagnostic problems of conventional polymerase chain reaction (PCR) is indiscrimination of low parasitic loads in soil samples. The aim of this study is to determine the genetic diversity and identification of Toxocara spp. from public areas soil inferred by loop-mediated isothermal amplification (LAMP) assay. MATERIALS AND METHODS: A total of 180 soil samples were collected from various streets and public parks of northwest Iran. The DNA of recovered Toxocara eggs were extracted and amplified by PCR and LAMP following ZnSO4 flotation technique...
December 2016: Veterinary World
https://www.readbyqxmd.com/read/28077261/ventral-medullary-control-of-rapid-eye-movement-sleep-and-atonia
#20
Michael C Chen, Ramalingam Vetrivelan, Chun-Ni Guo, Catie Chang, Patrick M Fuller, Jun Lu
Discrete populations of neurons at multiple levels of the brainstem control rapid eye movement (REM) sleep and the accompanying loss of postural muscle tone, or atonia. The specific contributions of these brainstem cell populations to REM sleep control remains incompletely understood. Here we show in rats that viral vector-based lesions of the ventromedial medulla at a level rostral to the inferior olive (pSOM) produced violent myoclonic twitches and abnormal electromyographic spikes, but not complete loss of tonic atonia, during REM sleep...
January 7, 2017: Experimental Neurology
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