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https://www.readbyqxmd.com/read/29473031/-find-cancer-early-evaluation-of-a-community-education-campaign-to-increase-awareness-of-cancer-signs-and-symptoms-in-people-in-regional-western-australians
#1
REVIEW
Emma Jane Croager, Victoria Gray, Iain Stephen Pratt, Terry Slevin, Simone Pettigrew, C D'arcy Holman, Max Bulsara, Jon Emery
Introduction: Cancer outcomes for people living in rural and remote areas are worse than for those living in urban areas. Although access to and quality of cancer treatment are important determinants of outcomes, delayed presentation has been observed in rural patients. Methods: Formative research with people from rural Western Australia (WA) led to the Find Cancer Early campaign. Find Cancer Early was delivered in three regions of WA, with two other regions acting as controls...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29470516/evaluation-of-diagnostic-methods-for-the-detection-of-intestinal-schistosomiasis-in-endemic-areas-with-low-parasite-loads-saline-gradient-helmintex-kato-katz-and-rapid-urine-test
#2
Warllem Junio Oliveira, Fernanda do Carmo Magalhães, Andressa Mariana Saldanha Elias, Vanessa Normandio de Castro, Vivian Favero, Catieli Gobetti Lindholz, Áureo Almeida Oliveira, Fernando Sergio Barbosa, Frederico Gil, Maria Aparecida Gomes, Carlos Graeff-Teixeira, Martin Johannes Enk, Paulo Marcos Zech Coelho, Mariângela Carneiro, Deborah Aparecida Negrão-Corrêa, Stefan Michael Geiger
BACKGROUND: In some tropical countries, such as Brazil, schistosomiasis control programs have led to a significant reduction in the prevalence and parasite burden of endemic populations. In this setting, the Kato-Katz technique, as the standard diagnostic method for the diagnosis of Schistosoma mansoni infections, which involves the analysis of two slides from one fecal sample, loses its sensitivity. As a result, a significant number of infected individuals are not detected. The objective of this study was to perform extensive parasitological testing of up to three fecal samples and include a rapid urine test (POC-CCA) in a moderate prevalence area in Northern Minas Gerais, Brazil, and evaluate the performance of each test separately and in combination...
February 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29462762/acetylcholinesterase-of-mangrove-oyster-crassostrea-rhizophorae-a-highly-thermostable-enzyme-with-promising-features-for-estuarine-biomonitoring
#3
Paula Rayane de Souza, Kelma Sirleide de Souza, Caio Rodrigo Dias de Assis, Marlyete Chagas de Araújo, Kaline Catiely Campos Silva, Juliett de Fátima Xavier da Silva, Andreia Cybelle Marques Ferreira, Valdir Luna da Silva, Mônica Lúcia Adam, Luiz Bezerra de Carvalho, Ranilson de Souza Bezerra
Enzyme biomarkers from several aquatic organisms have been used for assessing the exposure to contaminants at sublethal levels. Amongst them, the cholinesterases are commonly extracted from several organisms to evaluate/measure organophosphate and carbamate neurotoxic effects. Acetylcholinesterase (AChE; EC 3.1.1.7) is an enzyme of the group of serine esterases that acts on the hydrolysis of the neurotransmitter acetylcholine allowing the intermittence of the nerve impulses responsible for the neuronal communication...
February 12, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29434015/trust-in-health-information-sources-survey-analysis-of-variation-by-sociodemographic-and-tobacco-use-status-in-oklahoma
#4
Cati G Brown-Johnson, Lindsay M Boeckman, Ashley H White, Andrea D Burbank, Sjonna Paulson, Laura A Beebe
BACKGROUND: Modern technology (ie, websites and social media) has significantly changed social mores in health information access and delivery. Although mass media campaigns for health intervention have proven effective and cost-effective in changing health behavior at a population scale, this is best studied in traditional media sources (ie, radio and television). Digital health interventions are options that use short message service/text messaging, social media, and internet technology...
February 12, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29432084/the-relationship-between-drug-use-settings-roles-in-the-drug-economy-and-witnessing-a-drug-overdose-in-baltimore-maryland
#5
Carl A Latkin, Catie Edwards, Melissa A Davey-Rothwell, Cui Yang, Karin E Tobin
BACKGROUND: There has been a dramatic increase in drug overdose deaths in the US. In the current study, we examined factors associated with witnessing a drug overdose. METHODS: A sample of 450 substance users in Baltimore, Maryland, US were recruited for a behavioral intervention and were administered a survey. Multinomial logistic regression models were used to compare participants who never witnessed a drug overdose to those who witnessed one in the prior six months and those who witnessed an overdose over six months ago...
February 12, 2018: Substance Abuse
https://www.readbyqxmd.com/read/29426469/implications-of-zoonotic-and-vector-borne-parasites-to-free-roaming-cats-in-central-spain
#6
A Montoya, M García, R Gálvez, R Checa, V Marino, J Sarquis, J P Barrera, C Rupérez, L Caballero, C Chicharro, I Cruz, G Miró
Cats are definitive hosts and reservoirs for several parasites, some of which are responsible for serious zoonotic diseases. We conducted a case-control study of data from a trap-neuter-return (TNR) programme (years 2014-2017) designed to examine the prevalence of zoonotic parasites in free-roaming cats living in urban areas of central Spain. In the animal population tested (n = 263), we detected a 29.2% prevalence of endoparasites, including high rates of cestodes (12.9%) and Toxocara cati (11.7%). While faecal samples showed no Toxoplasma gondii oocysts, the seroprevalence of T...
February 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29410938/sensitivity-of-the-positive-and-negative-syndrome-scale-panss-in-detecting-treatment-effects-via-network-analysis
#7
Farnaz Zamani Esfahlani, Hiroki Sayama, Katherine Frost Visser, Gregory P Strauss
Objective: The Positive and Negative Syndrome Scale is a primary outcome measure in clinical trials examining the efficacy of antipsychotic medications. Although the Positive and Negative Syndrome Scale has demonstrated sensitivity as a measure of treatment change in studies using traditional univariate statistical approaches, its sensitivity to detecting network-level changes in dynamic relationships among symptoms has yet to be demonstrated using more sophisticated multivariate analyses. In the current study, we examined the sensitivity of the Positive and Negative Syndrome Scale to detecting antipsychotic treatment effects as revealed through network analysis...
December 1, 2017: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/29398365/the-basal-forebrain-regulates-global-resting-state-fmri-fluctuations
#8
Janita Turchi, Catie Chang, Frank Q Ye, Brian E Russ, David K Yu, Carlos R Cortes, Ilya E Monosov, Jeff H Duyn, David A Leopold
Patterns of spontaneous brain activity, typically measured in humans at rest with fMRI, are used routinely to assess the brain's functional organization. The mechanisms that generate and coordinate the underlying neural fluctuations are largely unknown. Here we investigate the hypothesis that the nucleus basalis of Meynert (NBM), the principal source of widespread cholinergic and GABAergic projections to the cortex, contributes critically to such activity. We reversibly inactivated two distinct sites of the NBM in macaques while measuring fMRI activity across the brain...
January 31, 2018: Neuron
https://www.readbyqxmd.com/read/29391367/impact-of-sex-work-on-risk-behaviours-and-their-association-with-hiv-positivity-among-people-who-inject-drugs-in-eastern-central-canada-cross-sectional-results-from-an-open-cohort-study
#9
Laurence Campeau, Karine Blouin, Pascale Leclerc, Michel Alary, Carole Morissette, Caty Blanchette, Bouchra Serhir, Elise Roy
OBJECTIVES: The objectives of this study were: (1) to examine the correlates of HIV positivity among participants who injected drugs and engaged in sex work (PWID-SWs) in the SurvUDI network between 2004 and 2016, after stratification by sex, and (2) to compare these correlates with those of sexually active participants who did not engage in sex work (PWID non-SWs). DESIGN AND SETTING: This biobehavioural survey is an open cohort of services where participants who had injected in the past 6 months were recruited mainly through harm reduction programmes in Eastern Central Canada...
January 31, 2018: BMJ Open
https://www.readbyqxmd.com/read/29389742/early-antihypertensive-treatment-and-clinical-outcomes-in-acute-ischemic-stroke-subgroup-analysis-by-baseline-blood-pressure
#10
William J He, Chongke Zhong, Tan Xu, Dali Wang, Yingxian Sun, Xiaoqing Bu, Chung-Shiuan Chen, Jinchao Wang, Zhong Ju, Qunwei Li, Jintao Zhang, Deqin Geng, Jianhui Zhang, Dong Li, Yongqiu Li, Xiaodong Yuan, Yonghong Zhang, Tanika N Kelly
BACKGROUND: We studied the effect of early antihypertensive treatment on death, major disability, and vascular events among patients with acute ischemic stroke according to their baseline SBP. METHODS: We randomly assigned 4071 acute ischemic stroke patients with SBP between 140 and less than 220 mmHg to receive antihypertensive treatment or to discontinue all antihypertensive medications during hospitalization. A composite primary outcome of death and major disability and secondary outcomes were compared between treatment and control stratified by baseline SBP levels of less than 160, 160-179, and at least 180 mmHg...
January 31, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29388930/-the-marketing-evaluation-of-the-consumers-preference-as-regards-the-use-of-medicinal-and-medicinal-table-mineral-waters
#11
D V Babaskin, L I Babaskina, A V Pavlova
The development of modern technologies in physiotherapy with the use of mineral waters, the expansion of the assortment of the medicinal and medicinal table waters as well as increasing the competitive advantages of domestic products require the more extensive marketing survey of the consumers' preferences in the market of mineral waters. AIM: The objective of the present study was the marketing evaluation of the consumers' preference in the segment of medicinal and medicinal table mineral waters in the city of Moscow...
December 28, 2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29384810/effects-of-repeated-intravitreal-aflibercept-injection-on-the-corneal-endothelium-in-patients-with-age-related-macular-degeneration-outcomes-from-the-re-view-study
#12
Jonathan H Lass, Beth Ann Benetz, Harry J Menegay, Constantinos P Tsipis, Jane Caty Cook, David S Boyer, Michael Singer, Kristine Erickson, Namrata Saroj, Robert Vitti, Karen W Chu, Hadi Moini, Yuhwen Soo, Yenchieh Cheng
PURPOSE: The effects of repeated intravitreal aflibercept injection (IAI) on the corneal endothelium were studied in patients with unilateral neovascular age-related macular degeneration. METHODS: RE-VIEW was a phase 4, open-label, single-arm, multicenter study. Patients received IAI every 8 weeks after 3 monthly doses. Slit-lamp biomicroscopy was performed at all study visits. The central corneal endothelial health was evaluated by specular microscopy in the treated versus untreated fellow eyes at baseline and weeks 24 and 52...
January 30, 2018: Cornea
https://www.readbyqxmd.com/read/29382857/neuroprotective-drug-for-nerve-trauma-revealed-using-artificial-intelligence
#13
David Romeo-Guitart, Joaquim Forés, Mireia Herrando-Grabulosa, Raquel Valls, Tatiana Leiva-Rodríguez, Elena Galea, Francisco González-Pérez, Xavier Navarro, Valerie Petegnief, Assumpció Bosch, Mireia Coma, José Manuel Mas, Caty Casas
Here we used a systems biology approach and artificial intelligence to identify a neuroprotective agent for the treatment of peripheral nerve root avulsion. Based on accumulated knowledge of the neurodegenerative and neuroprotective processes that occur in motoneurons after root avulsion, we built up protein networks and converted them into mathematical models. Unbiased proteomic data from our preclinical models were used for machine learning algorithms and for restrictions to be imposed on mathematical solutions...
January 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29374172/subcortical-evidence-for-a-contribution-of-arousal-to-fmri-studies-of-brain-activity
#14
Xiao Liu, Jacco A de Zwart, Marieke L Schölvinck, Catie Chang, Frank Q Ye, David A Leopold, Jeff H Duyn
Cortical activity during periods of rest is punctuated by widespread, synchronous events in both electrophysiological and hemodynamic signals, but their behavioral relevance remains unclear. Here we report that these events correspond to momentary drops in cortical arousal and are associated with activity changes in the basal forebrain and thalamus. Combining fMRI and electrophysiology in macaques, we first establish that fMRI transients co-occur with spectral shifts in local field potentials (LFPs) toward low frequencies...
January 26, 2018: Nature Communications
https://www.readbyqxmd.com/read/29355767/co-activation-patterns-in-resting-state-fmri-signals
#15
REVIEW
Xiao Liu, Nanyin Zhang, Catie Chang, Jeff H Duyn
The brain is a complex system that integrates and processes information across multiple time scales by dynamically coordinating activities over brain regions and circuits. Correlations in resting-state functional magnetic resonance imaging (rsfMRI) signals have been widely used to infer functional connectivity of the brain, providing a metric of functional associations that reflects a temporal average over an entire scan (typically several minutes or longer). Not until recently was the study of dynamic brain interactions at much shorter time scales (seconds to minutes) considered for inference of functional connectivity...
January 17, 2018: NeuroImage
https://www.readbyqxmd.com/read/29349429/repair-of-a-mycotic-abdominal-aortic-aneurysm-in-a-neonate-using-an-everted-jugular-vein-patch
#16
Samantha L Ahle, Jonathan A Cardella, Muriel A Cleary, David H Stitelman, Timur P Sarac, Michael G Caty
A 43-day-old boy presented with bacteremia after umbilical artery catheterization. Duplex ultrasound examination revealed a 1.1- × 1.6-cm mycotic infrarenal aortic aneurysm and an incidental asymptomatic occluded right common iliac artery. Resection and repair were completed by creating an everted, double-layered internal jugular vein patch. Screening ultrasound examination 10 months postoperatively demonstrated successful repair.
December 2017: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29322930/ontological-representation-integration-and-analysis-of-lincs-cell-line-cells-and-their-cellular-responses
#17
Edison Ong, Jiangan Xie, Zhaohui Ni, Qingping Liu, Sirarat Sarntivijai, Yu Lin, Daniel Cooper, Raymond Terryn, Vasileios Stathias, Caty Chung, Stephan Schürer, Yongqun He
BACKGROUND: Aiming to understand cellular responses to different perturbations, the NIH Common Fund Library of Integrated Network-based Cellular Signatures (LINCS) program involves many institutes and laboratories working on over a thousand cell lines. The community-based Cell Line Ontology (CLO) is selected as the default ontology for LINCS cell line representation and integration. RESULTS: CLO has consistently represented all 1097 LINCS cell lines and included information extracted from the LINCS Data Portal and ChEMBL...
December 21, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29321829/dna-methylation-in-stroke-update-of-latest-advances
#18
REVIEW
Jerzy Krupinski, Caty Carrera, Elena Muiño, Nuria Torres, Raid Al-Baradie, Natalia Cullell, Israel Fernandez-Cadenas
Epigenetic modifications are hereditable and modifiable factors that do not alter the DNA sequence. These epigenetic factors include DNA methylation, acetylation of histones and non-coding RNAs. Epigenetic factors have mainly been associated with cancer but also with other diseases and conditions such as diabetes or obesity. In addition, epigenetic modifications could play an important role in cardiovascular diseases, including stroke. We review the latest advances in stroke epigenetics, focusing on DNA methylation studies and the future perspectives in this field...
2018: Computational and Structural Biotechnology Journal
https://www.readbyqxmd.com/read/29321335/serum-hepatocyte-growth-factor-is-probably-associated-with-3-month-prognosis-of-acute-ischemic-stroke
#19
Zhengbao Zhu, Tan Xu, Daoxia Guo, Xinfeng Huangfu, Chongke Zhong, Jingyuan Yang, Aili Wang, Chung-Shiuan Chen, Yanbo Peng, Tian Xu, Jinchao Wang, Yingxian Sun, Hao Peng, Qunwei Li, Zhong Ju, Deqin Geng, Jing Chen, Yonghong Zhang, Jiang He
BACKGROUND AND PURPOSE: Serum hepatocyte growth factor (HGF) is positively associated with poor prognosis of heart failure and myocardial infarction, and it can also predict the risk of ischemic stroke in population. The goal of this study was to investigate the association between serum HGF and prognosis of ischemic stroke. METHODS: A total of 3027 acute ischemic stroke patients were included in this post hoc analysis of the CATIS (China Antihypertensive Trial in Acute Ischemic Stroke)...
January 10, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29316527/contrasting-effects-of-individual-versus-combined-estrogen-and-progestogen-regimens-as-working-memory-load-increases-in-middle-aged-ovariectomized-rats-one-plus-one-does-not-equal-two
#20
Alesia V Prakapenka, Ryoko Hiroi, Alicia M Quihuis, Catie Carson, Shruti Patel, Claire Berns-Leone, Carly Fox, Rachael W Sirianni, Heather A Bimonte-Nelson
Most estrogen-based hormone therapies are administered in combination with a progestogen, such as Levonorgestrel (Levo). Individually, the estrogen 17β-estradiol (E2) and Levo can improve cognition in preclinical models. However, although these hormones are often given together clinically, the impact of the E2 + Levo combination on cognitive function has yet to be methodically examined. Thus, we investigated E2 + Levo treatment on a cognitive battery in middle-aged, ovariectomized rats. When administered alone, E2 and Levo treatments each enhanced spatial working memory relative to vehicle treatment, whereas the E2 + Levo combination impaired high working memory load performance relative to E2 only and Levo only treatments...
December 7, 2017: Neurobiology of Aging
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