keyword
MENU ▼
Read by QxMD icon Read
search

i

keyword
https://www.readbyqxmd.com/read/29694996/surgery-for-congenital-heart-disease-improvements-in-outcomes
#1
Gerard R Martin, Richard A Jonas
Cardiac surgery for congenital heart disease has changed dramatically since the first surgery in 1938. During the early era, children underwent surgery at older ages often with palliative procedures before their corrective operation. Not surprisingly, in the early era, there was considerably higher early and late mortality, including the additive risks of having more than one procedure and a long period of living with an unphysiological palliated circulation. Over time with advances in noninvasive diagnosis, surgical approach, cardiopulmonary bypass techniques, and team-based care, outcomes have improved...
May 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29694993/new-ventilator-strategies-high-frequency-oscillatory-ventilation-combined-with-volume-guarantee
#2
M Sánchez-Luna, N González-Pacheco, J Belik, M Santos, F Tendillo
High-frequency oscillatory ventilation (HFOV) has been proposed as an alternative method of invasive ventilation in immature infants to prevent ventilator lung injury. To better control the size of the high-frequency tidal volume and to prevent large tidal volumes, a new strategy of controlling the tidal volume during HFOV (VThf) has been developed, HFOV-volume guarantee (VG). Data from preclinical, neonatal animal studies in normal and surfactant-depleted lungs have demonstrated the feasibility of this technique to directly control the VThf in the normal compliance and low compliance situations...
May 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29694970/repetitive-negative-thinking-and-its-role-in-perinatal-mental-health
#3
Michelle L Moulds, Melissa J Black, Jill M Newby, Colette R Hirsch
BACKGROUND: There is evidence that anxiety is common, perhaps even more prevalent than depression, in the post-partum period. In this review we propose adopting a transdiagnostic approach to perinatal mental health: to delineate psychopathology and identify potential underlying cognitive mechanisms such as repetitive negative thinking (RNT). SAMPLING AND METHODS: We provide an overview of key studies of RNT in perinatal mental health and suggest directions for future work...
April 25, 2018: Psychopathology
https://www.readbyqxmd.com/read/29694969/clinical-features-of-hereditary-angioedema-in-korean-patients-a-nationwide-multicenter-study
#4
Jae-Woo Jung, Dong In Suh, Hye Jung Park, Sujeong Kim, Hyouk Soo Kwon, Min Suk Yang, Chan Sun Park, Joo-Hee Kim, Sae-Hoon Kim, Yong Won Lee, Gyu Young Hur, Young-Min Ye, Yong Eun Kwon, Hye-Kyung Park, Cheol Woo Kim, Young-Il Koh, Jung Wong Park, Jong-Myung Lee, Kyung-Up Min, Paige Wickner, Hye-Ryun Kang
BACKGROUND: Hereditary angioedema (HAE) is a genetically heterogeneous autosomal dominant disorder characterized by recurrent episodes of nonpruritic, nonpitting edema increasing after puberty. It can be fatal due to laryngeal or gastrointestinal (GI) involvement with varied and changing frequency of mortality according to studies published from the Western countries. Epidemiological and clinical data of HAE in Asian countries are sparse. We sought to examine the clinical characteristics of HAE patients in Korea...
April 25, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29694968/a-rare-cause-of-juvenile-stroke-extracranial-carotid-artery-aneurysm-with-venous-complete-reconstruction-of-the-carotid-bifurcation
#5
Maurizio Domanin, Silvia Lanfranconi, Silvia Romagnoli, Letterio Runza, Francesca Cortini, Giacomo Piero Comi, Livio Gabrielli
Extracranial carotid artery aneurysms (ECAA) are a rare cause of embolic stroke. The underlying etiology is variable, with atherosclerosis being the most common entity in older subjects. Several treatments have been developed over the last 20 years, but the preferred method remains unknown. Notwithstanding the widespread use of endovascular techniques, surgical reconstruction by means of a bifurcated venous bypass graft should be applied in younger patients. In this way, it is possible to avoid major concerns about the development of long-term intrastent restenosis, and also to spare the external carotid artery which represents the main branch for the ipsilateral cerebral and facial perfusion...
April 25, 2018: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29694943/geochemical-signature-of-norm-waste-in-brazilian-oil-and-gas-industry
#6
G T De-Paula-Costa, I C Guerrante, J Costa-de-Moura, F C Amorim
The Brazilian Nuclear Energy Agency (CNEN) is responsible for any radioactive waste storage and disposal in the country. The storage of radioactive waste is carried out in the facilities under CNEN regulation and its disposal is operated, managed and controlled by the CNEN. Oil NORM (Naturally Occurring Radioactive Materials) in this article refers to waste coming from oil exploitation. Oil NORM has called much attention during the last decades, mostly because it is not possible to determine its primary source due to the actual absence of a regulatory control mechanism...
April 22, 2018: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29694937/migration-of-plasticizers-from-poly-vinyl-chloride-and-multilayer-infusion-bags-using-selective-extraction-and-gc-ms
#7
Zohra Haned, Saad Moulay, Silvia Lacorte
Flexible poly(vinyl chloride) (PVC) is widely used in the pharmaceutical industry for the manufacture of medical devices (tubes, probes, bags, primary packaging, etc.). The objective of the present study was to develop a procedure to evaluate the migration potential of nine plastic additives in aqueous infusion bags (NaCl 0.9% and glucose 5%): five phthalates, one adipate, two alkylphenols, and benzophenone. Two types of materials were analyzed: (i) new and outdated plasticized PVC (containing 40% of diethylhexyl phthalate DEHP); and (ii) tri-laminate polyethylene-polyamide-polypropylene, a multilayer material presumably exempt from DEHP...
April 12, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29694935/does-dissociation-mediate-the-relationship-between-childhood-trauma-and-hallucinations-delusions-in-first-episode-psychosis
#8
Pamela Sun, Mario Alvarez-Jimenez, Katrina Simpson, Katherine Lawrence, Natalie Peach, Sarah Bendall
BACKGROUND: Childhood trauma has been linked to the presence of delusions and hallucinations in psychosis, although the mechanisms underlying this relationship require elucidation. Dissociation, characterized by disruptions to the integrative functioning of several core mental domains, has emerged as a potential mechanism. There is a paucity of research using a clinician-rated measure of dissociation to test the indirect effect of dissociation on the relationship between childhood trauma and psychotic symptoms...
April 11, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29694899/to-make-a-long-spindle-short-nuclear-envelope-breakdown-during-meiosis
#9
Joseph M Varberg, Sue L Jaspersen
In fission yeast, the nuclear envelope (NE) remains intact during mitosis and meiosis I but is compromised during meiosis II. In this issue of Cell Reports, Flor-Parra et al. (2018) demonstrate that this NE alteration regulates meiosis II spindle disassembly and the ploidy of meiotic products.
April 24, 2018: Cell Reports
https://www.readbyqxmd.com/read/29694898/th1-like-plasmodium-specific-memory-cd4-t-cells-support-humoral-immunity
#10
Ryan A Zander, Rahul Vijay, Angela D Pack, Jenna J Guthmiller, Amy C Graham, Scott E Lindner, Ashley M Vaughan, Stefan H I Kappe, Noah S Butler
No abstract text is available yet for this article.
April 24, 2018: Cell Reports
https://www.readbyqxmd.com/read/29694889/pro-inflammation-associated-with-a-gain-of-function-mutation-r284s-in-the-innate-immune-sensor-sting
#11
Hiroyasu Konno, Ivan K Chinn, Diana Hong, Jordan S Orange, James R Lupski, Alejandra Mendoza, Luis A Pedroza, Glen N Barber
The cellular sensor stimulator of interferon genes (STING) initiates type I interferon (IFN) and cytokine production following association with cyclic dinucleotides (CDNs) generated from intracellular bacteria or via a cellular synthase, cGAS, after binding microbial or self-DNA. Although essential for protecting the host against infection, unscheduled STING signaling is now known to be responsible for a variety of autoinflammatory disorders. Here, we report a gain-of-function mutation in STING (R284S), isolated from a patient who did not require CDNs to augment activity and who manifested a constitutively active phenotype...
April 24, 2018: Cell Reports
https://www.readbyqxmd.com/read/29694886/multiplexed-quantitation-of-intraphagocyte-mycobacterium-tuberculosis-secreted-protein-effectors
#12
Fadel Sayes, Catherine Blanc, Louis S Ates, Nathalie Deboosere, Mickael Orgeur, Fabien Le Chevalier, Matthias I Gröschel, Wafa Frigui, Ok-Ryul Song, Richard Lo-Man, Florence Brossier, Wladimir Sougakoff, Daria Bottai, Priscille Brodin, Pierre Charneau, Roland Brosch, Laleh Majlessi
The pathogenic potential of Mycobacterium tuberculosis largely depends on ESX secretion systems exporting members of the multigenic Esx, Esp, and PE/PPE protein families. To study the secretion and regulation patterns of these proteins while circumventing immune cross-reactions due to their extensive sequence homologies, we developed an approach that relies on the recognition of their MHC class II epitopes by highly discriminative T cell receptors (TCRs) of a panel of T cell hybridomas. The latter were engineered so that each expresses a unique fluorescent reporter linked to specific antigen recognition...
April 24, 2018: Cell Reports
https://www.readbyqxmd.com/read/29694879/positive-feedback-mechanisms-among-local-ca-releases-ncx-and-i-cal-ignite-pacemaker-action-potentials
#13
Alexey E Lyashkov, Joachim Behar, Edward G Lakatta, Yael Yaniv, Victor A Maltsev
No abstract text is available yet for this article.
April 24, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29694870/protein-partitioning-into-ordered-membrane-domains-insights-from-simulations
#14
Xubo Lin, Alemayehu A Gorfe, Ilya Levental
Cellular membranes are laterally organized into domains of distinct structures and compositions by the differential interaction affinities between various membrane lipids and proteins. A prominent example of such structures are lipid rafts, which are ordered, tightly packed domains that have been widely implicated in cellular processes. The functionality of raft domains is driven by their selective recruitment of specific membrane proteins to regulate their interactions and functions; however, there have been few general insights into the factors that determine the partitioning of membrane proteins between coexisting liquid domains...
April 24, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29694865/rotation-activated-and-cooperative-zipping-characterize-class-i-viral-fusion-protein-dynamics
#15
Nathanial R Eddy, José N Onuchic
Class I viral fusion proteins are α-helical proteins that facilitate membrane fusion between viral and host membranes through large conformational transitions. Although prefusion and postfusion crystal structures have been solved for many of these proteins, details about how they transition between these states have remained elusive. This work presents the first, to our knowledge, computational survey of transitions between pre- and postfusion configurations for several class I viral fusion proteins using structure-based models to analyze their dynamics...
April 24, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29694860/unusual-isothermal-hysteresis-in-dna-i-motif-ph-transitions-a-study-of-the-rad17-promoter-sequence
#16
R Aaron Rogers, Aaron M Fleming, Cynthia J Burrows
We have interrogated the isothermal folding behavior of the DNA i-motif of the human telomere, dC19 , and a high-stability i-motif-forming sequence in the promoter of the human DNA repair gene RAD17 using human physiological solution and temperature conditions. We developed a circular-dichroism-spectroscopy-based pH titration method that is followed by analysis of titration curves in the derivative domain and found that the observed pH-dependent folding behavior can be significantly different and, in some cases, multiphasic, with a dependence on how rapidly i-motif folding is induced...
April 24, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29694852/back-to-basics-a-methodological-perspective-on-marble-burying-behavior-as-a-screening-test-for-psychiatric-illness
#17
Geoffrey de Brouwer, De Wet Wolmarans
Animal models of human psychiatric illness are valuable frameworks to investigate the etiology and neurobiology underlying the human conditions. Accurate behavioral measures that can be used to characterize animal behavior, thereby contributing to a model's validity, are crucial. One such measure, i.e. the rodent marble-burying test (MBT), is often applied as a measure of anxiety- and compulsive-like behaviors. However, the test is characterized by noteworthy between-laboratory methodological differences and demonstrates positive treatment responses to an array of pharmacotherapies that are often of little translational value...
April 22, 2018: Behavioural Processes
https://www.readbyqxmd.com/read/29694845/interoceptive-inference-from-computational-neuroscience-to-clinic
#18
REVIEW
Andrew P Owens, Micah Allen, Sasha Ondobaka, Karl J Friston
The central and autonomic nervous systems can be defined by their anatomical, functional and neurochemical characteristics, but neither functions in isolation. For example, fundamental components of autonomically mediated homeostatic processes are afferent interoceptive signals reporting the internal state of the body and efferent signals acting on interoceptive feedback assimilated by the brain. Recent predictive coding (interoceptive inference) models formulate interoception in terms of embodied predictive processes that support emotion and selfhood...
April 22, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29694842/baseline-striatal-and-nigral-interneuronal-protein-levels-in-two-distinct-mice-strains-differ-in-accordance-with-their-mptp-susceptibility
#19
Bidisha Bhaduri, P L Abhilash, Phalguni Anand Alladi
Epidemiological studies reveal an ethnicity-based bias in prevalence of Parkinson's disease (PD), deriving from the differences that exist between Caucasians and African or Asian populations. Experimental mice models provide a scope to analyse the cellular mechanisms of differential susceptibility to PD. C57BL/6 J mice, for instance, are more susceptible to MPTP-induced Parkinsonism whereas CD-1 mice are resistant. In PD-pathogenesis, interneuronal contribution is also likely, although they comprise only 5-10% of the striatal cells...
April 22, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29694834/utilization-of-13-c-labeled-amino-acids-to-probe-the-%C3%AE-helical-local-secondary-structure-of-a-membrane-peptide-using-electron-spin-echo-envelope-modulation-eseem-spectroscopy
#20
Lauren Bottorf, Indra D Sahu, Robert M McCarrick, Gary A Lorigan
Electron spin echo envelope modulation (ESEEM) spectroscopy in combination with site-directed spin labeling (SDSL) has been established as a valuable biophysical technique to provide site-specific local secondary structure of membrane proteins. This pulsed electron paramagnetic resonance (EPR) method can successfully distinguish between α-helices, β-sheets, and 310 -helices by strategically using 2 H-labeled amino acids and SDSL. In this study, we have explored the use of 13 C-labeled residues as the NMR active nuclei for this approach for the first time...
April 22, 2018: Biochimica et Biophysica Acta
keyword
keyword
19839
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"