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https://www.readbyqxmd.com/read/29684937/the-swedish-school-attack-in-trollh%C3%A3-ttan
#1
Åsa Erlandsson, J Reid Meloy
This is a case report of the offender and offense characteristics of a targeted attack on a Swedish school using a sword, with a particular focus upon the offender's history, the relationship between mental disorder and ideology, and whether or not it was an act of terrorism. Findings indicate that the offender had no drug or psychiatric treatment history, but postoffense analysis suggests autism spectrum disorder, depression, and both suicidal ideation and intent. The offender planned and prepared for his attack, and the triggering event appeared to be the loss of a temporary job...
April 23, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29684816/gaba-regulates-the-proliferation-and-apoptosis-of-mac-t-cells-through-the-lps-induced-tlr4-signaling-pathway
#2
Yue-Ying Wang, Shi-Ping Sun, He-Shui Zhu, Xian-Qin Jiao, Kai Zhong, Yu-Jie Guo, Guang-Ming Zha, Li-Qiang Han, Guo-Yu Yang, He-Ping Li
Subacute ruminal acidosis (SARA) can cause rapid lipopolysaccharide (LPS) elevation and milk yield decline in lactating ruminants. LPS has been shown to promote apoptosis and reduce the proliferation of mammary epithelial cells. Previous studies have shown that γ- amino butyric acid (GABA) can enhance production performance, regulating β-cell apoptosis and proliferation. Whether GABA can regulate apoptosis and proliferation induced by LPS in mammary epithelial cells is unknown. In this paper, we detected the role of GABA on proliferation and apoptosis as well as inflammation induced by LPS in bovine mammary epithelial cells (MAC-T cell line)...
April 18, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29684717/photobiomodulation-mechanisms-in-the-kinetics-of-the-wound-healing-process-in-rats
#3
A N Otterço, A L Andrade, P Brassolatti, K N Z Pinto, H S S Araújo, N A Parizotto
OBJECTIVES: The healing process of cutaneous lesions is considered a complex event divided into distinct and overlapping phases, which responds satisfactorily to photobiomodulation (PBM). PBM is indicated as a therapeutic resource capable of assisting tissue repair. The present study aimed to analyze the kinetics of cutaneous wounds healing process after application of the GaAlAs laser for treating wounds on the dorsum of rats. MATERIALS AND METHODS: This study was approved by the Animal Ethics Committee of UFSCar...
April 8, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29684692/acute-toxic-responses-of-embryo-larval-zebrafish-to-zinc-pyrithione-zpt-reveal-embryological-and-developmental-toxicity
#4
Ye Zhao, Yuyang Liu, Jing Sun, Hongtao Sha, Yu Yang, Qian Ye, Qi Yang, Baoqi Huang, Yadong Yu, He Huang
Zinc pyrithione (ZPT) is widely used in industrial and human daily life, due to its broad antimicrobial spectrum activity. Persistent accumulation of ZTP in the aquatic environment and bioaccumulation in the living organisms attracts more and more attention. However, only very limited information is available so far for the evaluation of systematic toxicity effects of ZPT on multiple organs development. This study intends to deepen our knowledge about the potential toxicity elicited by ZPT by assessing its acute effects on zebrafish (Danio rerio) through morphological, histological and molecular investigations...
April 6, 2018: Chemosphere
https://www.readbyqxmd.com/read/29684669/the-impact-of-associated-injuries-and-fracture-classifications-on-the-treatment-of-capitellum-and-trochlea-fractures-a-systematic-review-and-meta-analysis
#5
REVIEW
Shu-Kun He, Long Xu, Jin-Hai Guo, Jing-Ping Liao, Ting-Wu Qin, Fu-Guo Huang
BACKGROUND: Capitellum and trochlea fractures are truly rare and the treatment is not fully appreciated. So we evaluate the impact of associated injuries and fracture classifications on elbow functional outcomes after open reduction and internal fixation. MATERIALS AND METHODS: PubMed, Embase, Ovid Medline, and the Cochrane Library were searched from January 1, 1974 to January 1, 2017. All English literature with the treatment of capitellum and trochlea fractures by open reduction and internal fixation were included...
April 20, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29684624/component-effect-of-stem-cell-loaded-thermosensitive-polypeptide-hydrogels-on-cartilage-repair
#6
He Liu, Yilong Cheng, Jinjin Chen, Fei Chang, Jincheng Wang, Jianxun Ding, Xuesi Chen
Biophysical properties of the desired biomimetic scaffolds, such as porosity and elasticity, have been proven associated with the efficacy of cartilage regeneration. In this work, the copolymers of poly(L-alanine)-block-poly(ethylene glycol)-block-poly(L-alanine) (PA-PEG-PA) and poly(L-alanine-co-L-phenylalanine)-block-poly(ethylene glycol)-block-poly(L-alanine-co-L-phenylalanine) (PAF-PEG-PAF) with different ratios of alanine to phenylalanine were synthesized. The introduction of a hydrophobic amino acid, phenylalanine, into polyalanine-based thermosensitive hydrogel leaded to the enhanced gelation behaviors and upregulated mechanical properties...
April 20, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29684584/deletion-of-epithelial-cell-specific-cdc42-leads-to-enamel-hypermaturation-in-a-conditional-knockout-mouse-model
#7
Zhihui Tian, Xiaolin Lv, Min Zhang, Xueer Wang, Yinghua Chen, Pei Tang, Pengcheng Xu, Lu Zhang, Buling Wu, Lin Zhang
Recent evidence suggests that GTPases Rho family plays an important role in tooth development; however, the role of Cdc42 in tooth development remains unclear. We aimed to investigate the function of Cdc42 in tooth development and amelogenesis. We generated an epithelial cell-specific K5-Cdc42 knockout (KO) mouse to evaluate post-eruption dental phenotypes using a K5-Cre driver line. This model overcomes the previously reported perinatal lethality. Tooth phenotypes were analyzed by micro X-ray, micro-computed tomography (CT), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), wear rate, shear strength, and a microhardness test...
April 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29684363/immunolabeling-of-cleared-human-pancreata-provides-insights-into-three-dimensional-pancreatic-anatomy-and-pathology
#8
Michaël Noë, Neda Rezaee, Kaushal Asrani, Michael Skaro, Vincent P Groot, Pei-Hsun Wu, Matthew T Olson, Seung-Mo Hong, Sung Joo Kim, Matthew J Weiss, Christopher L Wolfgang, Martin A Makary, Jin He, John L Cameron, Denis Wirtz, Nicholas J Roberts, G Johan A Offerhaus, Lodewijk A A Brosens, Laura D Wood, Ralph H Hruban
Visualizing pathologies in three dimensions (3D) can provide unique insights into the biology of human diseases. A rapid and easy-to-implement dibenzyl ether-based technique was used to clear thick sections of surgically resected human pancreatic parenchyma. Protocols were applicable to both fresh and formalin-fixed paraffin-embedded tissue. The penetration of antibodies into dense pancreatic parenchyma was optimized using both gradually increasing antibody concentrations and centrifugal flow. Immunolabeling with antibodies against CK19 was visualized using both light sheet and confocal laser scanning microscopy...
April 20, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29684310/assessing-the-quality-of-life-in-patients-with-dentofacial-deformities-before-and-after-orthognathic-surgery
#9
Hong Sun, Hong-Tao Shang, Li-Sheng He, Ming-Chao Ding, Zhong-Ping Su, Yu-Lin Shi
PURPOSE: This study aimed to assess the effect of health-related quality of life (QoL) among patients with dentofacial deformities who underwent orthognathic surgery compared with a control group without dentofacial deformities by use of generic oral health and condition-specific approaches. PATIENTS AND METHODS: In this prospective study, 2 questionnaires were administered to 85 patients (31 male and 54 female patients) who were evaluated before undergoing orthognathic surgery...
March 31, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29684208/patellin1-negatively-modulates-salt-tolerance-by-regulating-pm-na-h-antiport-activity-and-cellular-redox-homeostasis-in-arabidopsis
#10
Huapeng Zhou, Chongwu Wang, Tinghong Tan, Jingqing Cai, Jiaxian He, Honghui Lin
Soil salinity significantly represses plant development and growth. Mechanisms involved sodium (Na+) extrusion and compartmentation, intracellular membrane trafficking as well as redox homeostasis regulation play important roles in plant salt tolerance. In this study, we report that Patellin1 (PATL1), a membrane trafficking-related protein, modulates salt tolerance in Arabidopsis. The T-DNA insertion mutant of PATL1 (patl1) with elevated PATL1 transcription level displays salt-sensitive phenotype. PATL1 partially associates with plasma membrane (PM) and endosomal system, and might participate in regulating membrane trafficking...
April 19, 2018: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29684073/nutrition-versus-defense-why-myzus-persicae-green-peach-aphid-prefers-and-performs-better-on-young-leaves-of-cabbage
#11
He-He Cao, Zhan-Feng Zhang, Xiao-Feng Wang, Tong-Xian Liu
Plant leaves of different ages differ in nutrients and toxic metabolites and thus exhibit various resistance levels against insect herbivores. However, little is known about the influence of leaf ontogeny on plant resistance to phloem-feeding insects. In this study, we found that the green peach aphid, Myzus persicae, preferred to settle on young cabbage leaves compared with mature or old leaves, although young leaves contained the highest concentration of glucosinolates. Furthermore, aphids feeding on young leaves had higher levels of glucosinolates in their body, but aphids performed better on young leaves in terms of body weight and population growth...
2018: PloS One
https://www.readbyqxmd.com/read/29683957/biliary-rhabdomyosarcoma-in-an-infant-male-with-neurofibromatosis-type-1
#12
Fatema Alhashem, Ebru Yilmaz, Mehmet A Ozdemir, Kemal Deniz, Ali Yikilmaz, Turkan Patiroglu, Musa Karakukcu, Ekrem Unal
Different types of malignancies can be seen in patients with neurofibromatosis type 1 (NF-1). Herein we present a rare combination of NF-1 and biliary rhabdomyosarcoma in a male infant. An 11-month-old boy, who was recently diagnosed with NF-1, presented to the outpatient clinic with a 3-month history of prolonged jaundice, and failure to thrive. Clinical examination showed >20 café au let spots distributed mainly over the abdominal trunk. Hepatomegaly (4 cm below the costal margin) was additionally observed...
April 20, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29683947/encephalocraniocutaneous-lipomatosis
#13
Abhishek Bavle, Rikin Shah, Naina Gross, Theresa Gavula, Alejandro Ruiz-Elizalde, Klaas Wierenga, Rene McNall-Knapp
A 5-year-old boy presented with worsening headaches for 3 months. On examination, he was found to have a hairless fatty tissue nevus of the scalp (nevus psiloliparus), subcutaneous soft tissue masses on the right side of his face, neck, mandible and right buttock and epibulbar dermoid of the right eye (choristoma) (Figs. 1A, B). Magnetic resonance imaging revealed a large suprasellar mass, which was debulked and found to be a pilocytic astrocytoma. Testing was not performed for the BRAF/KIAA1549 fusion or BRAFV600E mutation...
April 20, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29683856/seroconversion-on-prep-a-case-report-with-segmental-hair-analysis-for-timed-adherence-determination
#14
Joshua T Thaden, Monica Gandhi, Hideaki Okochi, Christopher B Hurt, Mehri S McKellar
OBJECTIVE: We describe the third case report of seroconversion with multidrug resistant (MDR)-HIV despite pre-exposure prophylaxis (PrEP) with emtricitabine (FTC) and tenofovir (TFV) disoproxil (TDF). DESIGN: Case report. METHODS: PrEP adherence was assessed via self-report, pharmacy records, and measuring TFV/FTC levels with liquid-chromatography/tandem-mass-spectrometry in plasma and hair. Segmental hair analysis was performed to assess PrEP adherence over prior months...
April 19, 2018: AIDS
https://www.readbyqxmd.com/read/29683785/association-study-of-cacna1c-polymorphisms-with-large-artery-atherosclerotic-stroke-in-chinese-han-population
#15
Chen Peng, Ying Ding, Xin Yi, Zhiqiang Dong, Limei Cao, Qiang Li, Haiyan Ren, Lin He, Daizhan Zhou, Xu Chen
Aims Ischemic stroke (IS) is one of the most common diseases of neurology and the main cause of death and disability in Chinese population. CACNA1C was considered to be involved in the process of atherosclerosis, but there was little information about the association between genotypic polymorphisms of CACNA1C and ischemic stroke. Our study was designed to elucidate the relationship between four single-nucleotide polymorphisms (SNPs) variants in CACNA1C gene and the risk of large-artery atherosclerotic (LAA) stroke patients...
April 23, 2018: Neurological Research
https://www.readbyqxmd.com/read/29683727/bone-turnover-markers-and-novel-biomarkers-in-lung-cancer-bone-metastases
#16
Jiangli Lang, Qian Zhao, Yuedong He, Xijie Yu
CONTEXT: Lung cancer still remains the leading cause of cancer-related mortality worldwide. Bone is one of preferred metastatic sites for lung cancer cells. So far, both accurate diagnosis and effective treatment of lung cancer bone metastases are difficult. OBJECTIVE: This review aimed to evaluate roles of bone turnover markers (BTMs), microRNAs (miRNAs), dickkopf1 (DKK1) and insulin like growth factor binding protein 3 (IGFBP-3) in lung cancer bone metastases...
April 23, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29683711/ambiguity-effects-of-rhyme-and-meter
#17
Sebastian Wallot, Winfried Menninghaus
Previous research has shown that rhyme and meter-although enhancing prosodic processing ease and memorability-also tend to make semantic processing more demanding. Using a set of rhymed and metered proverbs, as well as nonrhymed and nonmetered versions of these proverbs, the present study reveals this hitherto unspecified difficulty of comprehension to be specifically driven by perceived ambiguity. Roman Jakobson was the 1st to propose this hypothesis, in 1960. He suggested that "ambiguity is an intrinsic, inalienable feature" of "parallelistic" diction of which the combination of rhyme and meter is a pronounced example...
April 23, 2018: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/29683662/global-picture-of-protein-regulation-in-response-to-dibutyl-phthalate-dbp-stress-of-two-brassica-parachinensis-cultivars-differing-in-dbp-accumulation
#18
Hai-Ming Zhao, He-Biao Huang, Huan Du, Lei Xiang, Ce-Hui Mo, Yan-Wen Li, Quan-Ying Cai, Hui Li, Jie-Sheng Liu, Dong-Mei Zhou, Ming-Hung Wong
iTRAQ analysis was used to map the proteomes of two Brassica parachinensis cultivars that differed in DBP accumulation. A total of 5,699 proteins were identified to obtain 152 differentially regulated proteins, of which 64 and 48 were specific to a high and a low DBP-accumulation cultivar, respectively. Genotype-specific biological processes were involved in coping with DBP stress, accounting for the variation in DBP tolerance and accumulation. Formation of high DBP accumulation in B. parachinensis might attribute to the more effective regulation of protein expression in physiology and metabolism, including (a) enhanced cell wall biosynthesis and modification, (b) better maintenance of photosynthesis and energy balance, (c) greatly improved total capacity for antioxidation and detoxification, and (d) enhanced cellular transport and signal transduction...
April 23, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29683658/enhanced-biosynthesis-performance-of-heterologous-proteins-in-cho-k1-cells-using-crispr-cas9
#19
Wenpeng Wang, Wenyun Zheng, Fengzhi Hu, Xiujuan He, Dong Wu, Wenliang Zhang, Haipeng Liu, Xingyuan Ma
Chinese hamster ovary (CHO) cells are the famous expression system for industrial production of recombinant proteins, such as therapeutic antibodies. However, there retained still bottlenecks in protein quality and weakness in expression efficiency because of the intrinsic genetic properties of the cell. Here we have enhanced biosynthesis performance of heterologous proteins in CHO-K1 cell using CRISPR-Cas9 by editing the genome precisely with two genes for improving ER microenvironment and reinforcing anti-apoptotic ability...
April 23, 2018: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29683648/fabrication-and-release-behavior-of-microcapsules-with-double-layered-shell-containing-clove-oil-for-antibacterial-applications
#20
Yong Bing Chong, He Zhang, Chee Yoon Yue, Jinglei Yang
In this study, double layer polyurethane/polyurea-formaldehyde (PU/PUF) shell microcapsules containing clove oil with antibacterial properties were successfully synthesized via in situ and interfacial polymerization reactions in an oil-in-water emulsion. The morphology, core-shell structure and composition of the microcapsules were investigated systematically. Additionally, the release behaviors of microcapsules synthesized under different reaction parameters were studied. It was found that the release rate of clove oil can be controlled by tuning the amount of PU reactants and the length of PUF deposition time...
April 23, 2018: ACS Applied Materials & Interfaces
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