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https://www.readbyqxmd.com/read/28545269/-risk-factors-of-endometriosis-associated-ovarian-carcinoma-in-women-aged-45-years-and-older
#1
Z X He, S Wang, Z F Li, L Zhu, J H Leng, J H Lang
Obiective: To explore the risk factors of endometriosis-associated ovarian cancer (EAOC) in women with ovarian endometriosis aged 45 years and older in China. Methods: The medical records of total 1 038 women aged 45 years and older with a surgicopathological diagnosis of ovarian endometriosis treated at Peking Union Medical College Hospital from December 1994 to December 2014 were reviewed. Histology evaluation determined ovarian endometriosis with (n=30) or without (n=1 008) ovarian cancer. Results: (1) There were 30 (2...
May 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28545266/-analysis-of-misssed-diagnosis-and-misdiagnosis-of-1-212-cases-with-placental-abruption
#2
D Xu, C Liang, J W Xu, J He
Objective: To investigate the risk factors and clinical manifestations of placental abruption, and to analyze the causes of missed diagnosis and misdiagnosis. Methods: A retrospective analysis was conducted in 135 584 women who delivered in Women's Hospital, School of Medicine, Zhejiang University from January 2005 to December 2015. The diagnosis of placental abruption was made in 1 212 cases. According to the consistency of prenatal and postnatal diagnosis, they were divided into 3 groups. (1) The diagnosis was consistent prenatally and postnatally in 715 cases(58...
May 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28545156/the-boron-transporter-bnac4-bor1-1c-is-critical-for-inflorescence-development-and-fertility-under-boron-limitation-in-brassica-napus
#3
Quan Zhang, Haifei Chen, Mingliang He, Zhuqing Zhao, Hongmei Cai, Guangda Ding, Lei Shi, Fangsen Xu
Boron (B) is an essential micronutrient for plants, but the molecular mechanisms underlying the uptake and distribution of B in allotetraploid rapeseed (Brassica napus) are unclear. Here, we identified a B transporter of rapeseed, BnaC4.BOR1;1c, which expressed in shoot nodes and involved in distributing B to the reproductive organs. Transgenic Arabidopsis plants containing a BnaC4.BOR1;1c promoter-driven GUS reporter gene showed strong GUS activity in roots, nodal regions of the shoots and immature floral buds...
May 25, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28545034/characterization-of-sudan-ebolavirus-infection-in-ferrets
#4
Andrea Kroeker, Shihua He, Marc-Antoine de La Vega, Gary Wong, Carissa Embury-Hyatt, Xiangguo Qiu
Sudan virus (SUDV) outbreaks in Africa are highly lethal; however, the development and testing of novel antivirals and vaccines for this virus has been limited by a lack of suitable animal models. Non-human primates (NHP) remain the gold standard for modeling filovirus disease, but they are not conducive to screening large numbers of experimental compounds and should only be used to test the most promising candidates. Therefore, other smaller animal models are a valuable asset. We have recently developed a guinea-pig adapted SUDV virus that is lethal in guinea pigs...
May 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28545027/mir-486-5p-negatively-regulates-oncogenic-nek2-in-hepatocellular-carcinoma
#5
Shun-Jun Fu, Jian Chen, Fei Ji, Wei-Qiang Ju, Qiang Zhao, Mao-Gen Chen, Zhi-Yong Guo, Lin-Wei Wu, Yi Ma, Dong-Ping Wang, Xiao-Feng Zhu, Xiao-Shun He
NEK2 is a member of the NIMA-related family of serine/threonine centrosomal kinases. We analyzed the relationship between differential expression of NEK2 and hepatocellular carcinoma (HCC) patient outcomes after liver transplants. We also studied the microRNAs that affect NEK2 expression. Analysis of multiple microarrays in the Oncomine database revealed that NEK2 expression was higher in HCC tissues than adjacent normal liver tissues. High NEK2 expression correlated with tumor size, pathological grade and macro- and microvascular invasion...
May 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28544988/co-gasification-of-bituminous-coal-and-hydrochar-derived-from-municipal-solid-waste-reactivity-and-synergy
#6
Juntao Wei, Qinghua Guo, Qing He, Lu Ding, Kunio Yoshikawa, Guangsuo Yu
In this work, the influences of gasification temperature and blended ratio on co-gasification reactivity and synergy of Shenfu bituminous coal (SF) and municipal solid waste-derived hydrochar (HTC) were investigated using TGA. Additionally, active alkaline and alkaline earth metal (AAEM) transformation during co-gasification was quantitatively analyzed by inductively coupled plasma optical emission spectrometer for correlating synergy on co-gasification reactivity. The results showed that higher char gasification reactivity existed at higher HTC char proportion and gasification temperature, and the main synergy behaviour on co-gasification reactivity was performed as synergistic effect...
May 6, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28544935/liquiritin-lt-exhibits-suppressive-effects-against-the-growth-of-human-cervical-cancer-cells-through-activating-caspase-3-in-vitro-and-xenograft-mice-in-vivo
#7
She-Hong He, Hong-Gai Liu, Yu-Fei Zhou, Qing-Fen Yue
Cervical cancer is one of the most common female malignancies worldwide. Liquiritin (LT), a major constituent of Glycyrrhiza Radix, possesses a variety of pharmacological activities, including anti-cancer, anti-oxidative, anti-inflammatory and neuro-protective effects. However, its role in human cervical cancer remains to be elusive. In our study, we found that LT suppressed cervical cancer cell migration, invasion and cloning ability with little cytotoxicity to human normal cells. In addition, apoptosis was induced by LT in cervical cancer cells through activation of Caspase-3 and poly ADP-ribose polymerase (PARP) cleavage...
May 22, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28544912/parallel-gene-selection-and-dynamic-ensemble-pruning-based-on-affinity-propagation
#8
Jun Meng, Jing Zhang, Yu-Shi Luan, Xin-Yu He, Li-Shuang Li, Yuan-Feng Zhu
Gene selection and sample classification based on gene expression data are important research areas in bioinformatics. Selecting important genes closely related to classification is a challenging task due to high dimensionality and small sample size of microarray data. Extended rough set based on neighborhood has been successfully applied to gene selection, as it can select attributes without redundancy and deal with numerical attributes directly. However, the computation of approximations in rough set is extremely time consuming...
May 17, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28544670/the-clinical-significance-of-esophagogastric-junction-outflow-obstruction-and-hypercontractile-esophagus-in-high-resolution-esophageal-manometry
#9
D Schupack, D A Katzka, D M Geno, K Ravi
BACKGROUND: Although major manometric abnormalities, the significance of esophagogastric junction outflow obstruction (EGJOO) and hypercontractile esophagus (HE) is poorly understood. We sought to determine long term outcomes for EGJOO and HE. METHODS: High-resolution impedance manometry (HRIM) studies conducted from 5/30/2012 to 8/1/2014 consistent with EGJOO and HE and normal studies from 5/30/12 to 11/1/12 were identified. Standardized follow up was conducted with a phone survey utilizing the impact dysphagia questionnaire (IDQ-10)...
May 23, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28544569/maintenance-of-the-contractile-phenotype-in-corpus-cavernosum-smooth-muscle-cells-by-myocardin-gene-therapy-ameliorates-erectile-dysfunction-in-bilateral-cavernous-nerve-injury-rats
#10
H-B Zhang, Z-Q Wang, F-Z Chen, W Ding, W-B Liu, Z-R Chen, S-H He, A-Y Wei
The pathophysiology of erectile dysfunction post radical prostatectomy is not clearly clarified, and the low efficacy of traditional PDE5i treatment remains a major complaint in contemporary practice. This study aimed to demonstrate phenotypic modulation in bilateral cavernous nerve injury (BCNI) rats within 7 days, and subsequently validate gene therapy with Myocardin (Mycod) by maintaining a contractile phenotype in corpus cavernosum smooth muscle cells. Initially, 36 male rats were randomly divided into BCNI and negative control (NC) groups for histological and phenotypic molecular measurements at 3, 5, and 7 days...
May 23, 2017: Andrology
https://www.readbyqxmd.com/read/28544541/identification-and-analysis-of-chemical-constituents-and-rat-serum-metabolites-in-suan-zao-ren-granule-using-ultra-high-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-combined-with-multiple-data-processing-approaches
#11
Yiyang Du, Bosai He, Qing Li, Jiao He, Di Wang, Kaishun Bi
Suan-Zao-Ren granule is widely used to treat insomnia in China. However, because of the complexity and diversity of the chemical compositions in traditional Chinese medicine formula, the comprehensive analysis of constituents in vitro and in vivo are rather difficult. In our study, an ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry and the PeakView® software, which uses multiple data processing approaches including product ion filter, neutral loss filter and mass defect filter, method was developed to characterize the ingredients and rat serum metabolites in Suan-Zao-Ren granule...
May 24, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28544512/interferon-induced-transmembrane-protein-3-regulates-the-growth-and-invasion-of-human-lung-adenocarcinoma
#12
Dong Zhang, Huimin Wang, Huijie He, Haiying Niu, Yu Li
BACKGROUND: Interferon induced transmembrane protein 3 (IFITM3) plays an important role in the tumorigenesis and progression of multiple cancers. This study investigated the expression and function of IFITM3 in human lung adenocarcinoma. METHODS: Fifty human lung adenocarcinoma tissues were collected. IFITM3 expression was assessed by immunohistochemical staining. The clinicopathologic characteristics of all patients were analyzed. RESULTS: IFITM3 was mainly detected in the cytoplasm of advanced cancer tissues and its expression was correlated with tumor malignancy grade...
May 23, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28544438/genome-wide-identification-characterization-and-evolution-of-cuticular-protein-genes-in-the-malaria-vector-anopheles-sinensis-diptera-culicidae
#13
Bai-Qi Liu, Liang Qiao, Qi-Yi He, Yong Zhou, Shuang Ren, Bin Chen
Thirteen cuticular proteins (CPs) families have been recognized in arthropods. In this study, 250 Anopheles sinensis CP genes were identified and named based on genome and transcriptome sequences. They were classified into 10 families based on motifs and phylogenetic analyses. In 11 other insect species, 9 had CP numbers > 150 while Apis mellifera and Tribolium castaneum had CP numbers less than 52. The CPs of 8 species occupied > 1.4% of the total genomic gene number whereas in 3 species the CPs occupied < 1%...
May 24, 2017: Insect Science
https://www.readbyqxmd.com/read/28544388/healing-effect-of-controlled-anti-electromigration-on-conventional-and-high-tc-superconducting-nanowires
#14
Xavier D A Baumans, Joseph Lombardo, Jérémy Brisbois, Gorky Shaw, Vyacheslav S Zharinov, Ge He, Heshan Yu, Jie Yuan, Beiyi Zhu, Kui Jin, Roman B G Kramer, Joris Van de Vondel, Alejandro V Silhanek
The electromigration process has the potential capability to move atoms one by one when properly controlled. It is therefore an appealing tool to tune the cross section of monoatomic compounds with ultimate resolution or, in the case of polyatomic compounds, to change the stoichiometry with the same atomic precision. As demonstrated here, a combination of electromigration and anti-electromigration can be used to reversibly displace atoms with a high degree of control. This enables a fine adjustment of the superconducting properties of Al weak links, whereas in Nb the diffusion of atoms leads to a more irreversible process...
May 19, 2017: Small
https://www.readbyqxmd.com/read/28544358/the-expression-pattern-of-bcl11a-mdm2-and-pten-genes-in-b-cell-acute-lymphoblastic-leukemia
#15
Ling Xu, Hong Wu, Xiuli Wu, Yangqiu Li, Dongmei He
AIM: Bcl11a is closely associated with B-cell lymphoma and B-cell chronic lymphocytic leukemia. However, little is known about the expression character of Bcl11a gene in B-cell acute lymphoblastic leukemia (B-ALL). In previous study, our results showed there was a clear dysregulation in the global gene expression of the Bcl11a-suppressed B lymphoma cells. The aim of the study is to further evaluate the role of Bcl11a and the expression level of its related genes Mdm2, Pten in B-ALL patients...
May 24, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28544332/fibroblast-growth-factor-2-protects-against-renal-ischaemia-reperfusion-injury-by-attenuating-mitochondrial-damage-and-proinflammatory-signalling
#16
Xiao-Hua Tan, Xiao-Meng Zheng, Li-Xia Yu, Jian He, Hong-Mei Zhu, Xiu-Ping Ge, Xiao-Li Ren, Fa-Qing Ye, Saverio Bellusci, Jian Xiao, Xiao-Kun Li, Jin-San Zhang
Ischaemia-reperfusion injury (I/RI) is a common cause of acute kidney injury (AKI). The molecular basis underlying I/RI-induced renal pathogenesis and measures to prevent or reverse this pathologic process remains to be resolved. Basic fibroblast growth factor (FGF2) is reported to have protective roles of myocardial infarction as well as in several other I/R related disorders. Herein we present evidence that FGF2 exhibits robust protective effect against renal histological and functional damages in a rat I/RI model...
May 24, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28544231/dual-responsive-molecular-switches-based-on-dithienylethene-ru-ii-organometallics-in-self-assembled-monolayers-operating-at-low-voltage
#17
Andrea Mulas, Xiaoyan He, Yves-Marie Hervault, Lucie Norel, Stéphane Rigaut, Corinne Lagrost
Two carbon-rich ruthenium complexes bearing a dithienylethene (DTE) unit and a hexylthiol spacer were designed to be attached on gold surfaces. Both compounds display photochemically-driven switching properties, allowing reversible conversion from open to closed forms of the DTE units upon irradiation in solution. In contrast, only the bimetallic complex undergoes an efficient electrochemical ring closure at low potential, (0.5 V vs SCE), whereas the monometallic complex show a simple one electron reversible redox event...
May 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28544143/synthesis-of-aldehydes-by-organocatalytic-formylation-reactions-of-boronic-acids-with-glyoxylic-acid
#18
Wei Wang, He Huang, Chenguang Yu, Xiangmin Li, Yongqiang Zhang, Yueteng Zhang, Xiaobei Chen, Patrick S Mariano, Hexin Xie
We report a conceptually novel organocatalytic strategy for formylation of boronic acids, in which a new reactivity is engineered into the α-amino acid forming Petasis reaction occurring between aryl boron acids, amines and glyoxylic acid. The feasibility and preparative power of the protocol was demonstrated by its use to prepare aldehydes from broadly accessible aryl and alkenyl boronic acids, glyoxylic acid, and the cheap N-alkylaniline derivatives, tetrahydroquinoline and indoline, as catalysts. Furthermore, the operational simplicity of the process, which is performed by simply mixing these reagents under ambient conditions, and its ability to generate structurally diverse and valued aryl, heteroaryl and α,β-unsaturated aldehydes containing a wide array of functional groups, demonstrates the practical utility of the newly unveiled synthetic strategy...
May 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28544113/the-role-of-water-in-catalyst-free-aldol-reaction-of-water-insoluble-n-methyl-2-4-thiazolidinedione-with-n-methyl-isatin-from-qm-mm-monte-carlo-simulation
#19
Jianming Zhao, Fen He, Fan Zhang, Xin Yang, Zhiyue Tian, Ying Xue
The role of water in the uncatalyzed aldol reaction of N-methyl-2,4-thiazolidinedione with N-methyl-isatin has been investigated using Monte Carlo statistical mechanics simulations utilizing the free-energy perturbation theory and the QM/MM model with PDDG/PM3 for the QM method under the "on water" and dimethyl sulfoxide (DMSO) environments. There are several conceivable orientations between thiazolidinedione and isatin in the process of C-C bond formation. However, the formation of C-C bond takes place between the re face of isatin and the si face of E-enol of the thiazolidinedione to form the preferred anti-type product, which results from enhancing hydrogen bonding interaction between water molecules and the oxygen atoms undergoing bond broken and bond formation during the reaction...
May 23, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28544069/cd38-enhances-the-proliferation-and-inhibits-the-apoptosis-of-cervical-cancer-cells-by-affecting-the-mitochondria-functions
#20
Shan Liao, Songshu Xiao, Hongxiang Chen, Manying Zhang, Zhifang Chen, Yuehua Long, Lu Gao, Guangchao Zhu, Junyu He, Shuping Peng, Wei Xiong, Zhaoyang Zeng, Zheng Li, Ming Zhou, Xiaoling Li, Jian Ma, Minghua Wu, Juanjuan Xiang, Guiyuan Li, Yanhong Zhou
Cervical cancer is one of the most common malignant tumors in women all over the world. The exact mechanism of occurrence and development of cervical cancer has not been fully elucidated. CD38 is a type II transmembrane glycoprotein, which was found to mediate diverse activities, including signal transduction, cell adhesion, and cyclic ADP-ribose synthesis. Here, we reported that CD38 promoted cell proliferation and inhibited cell apoptosis in cervical cancer cells by affecting the mitochondria functions. We established stable cervical cancer cell lines with CD38 over-expressed...
May 23, 2017: Molecular Carcinogenesis
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