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https://www.readbyqxmd.com/read/28551800/high-density-lipoprotein-regulation-of-mitochondrial-function
#1
C Roger White, Geeta Datta, Samantha Giordano
Lipoproteins play a key role in regulating plasma and tissue levels of cholesterol. Apolipoprotein B (apoB)-containing lipoproteins, including chylomicrons, very-low density lipoprotein (VLDL) and low-density lipoprotein (LDL), serve as carriers of triglycerides and cholesterol and deliver these metabolites to peripheral tissues. In contrast, high-density lipoprotein (HDL) mediates Reverse Cholesterol Transport (RCT), a process by which excess cholesterol is removed from the periphery and taken up by hepatocytes where it is metabolized and excreted...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28539357/novel-association-of-tm6sf2-rs58542926-genotype-with-increased-serum-tyrosine-levels-and-decreased-apolipoprotein-b-100-particles-in-finns
#2
Daniel Seung Kim, Anne U Jackson, Yatong K Li, Heather M Stringham, Johanna Kuusisto, Antti J Kangas, Pasi Soininen, Mika Ala-Korpela, Charles F Burant, Veikko Salomaa, Michael Boehnke, Markku Laakso, Elizabeth K Speliotes
A glutamate-to-lysine variant (rs58542926-T) in transmembrane 6 superfamily member 2 (TM6SF2) is associated with increased fatty liver disease and diabetes in conjunction with decreased cardiovascular disease risk. To identify mediators of TM6SF2 effects, we tested for associations between rs58542926-T and serum lipoprotein/metabolite measures in cross-sectional data from non-diabetic, statin-naive participants. We identified independent associations between rs58542926-T and apolipoprotein B-100 particles (B=-0...
May 24, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28529180/structure-function-relationships-in-reconstituted-hdl-focus-on-antioxidative-activity-and-cholesterol-efflux-capacity
#3
Alexandre M O Cukier, Patrice Therond, Svetlana A Didichenko, Isabelle Guillas-Baudouin, M John Chapman, Samuel D Wright, Anatol Kontush
AIMS: High-density lipoprotein (HDL) contains multiple components that endow it with biological activities. Apolipoprotein A-I (apoA-I) and surface phospholipids contribute to these activities; however, structure-function relationships in HDL particles remain incompletely characterized. METHODS: Reconstituted HDLs (rHDLs) were prepared from apoA-I and soy phosphatidylcholine (PC) at molar ratios of 1:50, 1:100 and 1:150. Oxidative status of apoA-I was varied using controlled oxidation of Met112 residue...
May 18, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28525354/the-relationship-between-insulin-resistance-and-endothelial-dysfunction-in-obese-adolescents
#4
Preneet Cheema Brar, Payal Patel, Stuart Katz
BACKGROUND: Insulin resistance and endothelial dysfunction share a reciprocal relationship that links the metabolic and cardiovascular sequelae of obesity. We characterized the brachial artery reactivity testing (BART) and carotid artery-intima media thickness (CIMT) in adolescents categorized as obese insulin resistant (OIR) and obese not insulin resistant (ONIR). Lipoprotein particle (p) analysis and inflammatory cytokines in OIR and ONIR groups were also analyzed. METHODS: Obese adolescents (n=40; mean body mass index [BMI] 35...
May 18, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28515160/replacement-of-refined-starches-and-added-sugars-with-egg-protein-and-unsaturated-fats-increases-insulin-sensitivity-and-lowers-triglycerides-in-overweight-or-obese-adults-with-elevated-triglycerides
#5
Kevin C Maki, Orsolya M Palacios, Emily Lindner, Kristin M Nieman, Marjorie Bell, Jennifer Sorce
Background: Hypertriglyceridemia is a common condition in the United States and is often associated with other metabolic disturbances, including insulin resistance, metabolic syndrome, and a predominance of small dense LDL particles.Objective: The objective of this trial was to evaluate the effects of a combination of egg protein (Epro) and unsaturated fatty acids (UFAs) substituted for refined starches and added sugars on insulin sensitivity (primary outcome) and other cardiometabolic health markers in overweight or obese adults with elevated triglyceride (TG) concentrations...
May 17, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28515138/dalcetrapib-and-anacetrapib-differently-impact-hdl-structure-and-function-in-rabbits-and-monkeys
#6
Mathieu R Brodeur, David Rhainds, Daniel Charpentier, Téodora Mihalache-Avram, Mélanie Mecteau, Geneviève Brand, Evelyne Chaput, Anne Perez, Eric J Niesor, Eric Rhéaume, Cyrille Maugeais, Jean-Claude Tardif
Inhibition of cholesteryl ester transfer protein (CETP) increases high density lipoprotein cholesterol (HDL-C) levels. However, circulating CETP level varies and the impact of its inhibition in species with high CETP levels on HDL structure and function remains poorly characterized. This study investigated the effects of dalcetrapib and anacetrapib, the two CETP inhibitors (CETPi) currently tested in large clinical outcome trials, on HDL particle subclass distribution and cholesterol efflux capacity of serum in rabbits and monkeys...
May 17, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28511654/oxidative-profiles-of-ldl-and-hdl-isolated-from-women-with-preeclampsia
#7
G León-Reyes, R F Maida-Claros, A X Urrutia-Medina, E Jorge-Galarza, A M Guzmán-Grenfell, S Fuentes-García, R Medina-Navarro, M A Moreno-Eutimio, J L Muñoz-Sánchez, J J Hicks, Y D Torres-Ramos
BACKGROUND: Oxidative stress causes biochemical changes in lipids and proteins; these changes can induce damage to the vascular endothelium and create maternal complications that are characteristic of preeclampsia. In this study, we evaluated the oxidative profile of lipoproteins isolated from women with preeclampsia. METHODS: Thirty women diagnosed with preeclampsia and thirty women without preeclampsia were included in the study. Lipid-damage biomarkers, including conjugated dienes, lipohydroperoxides and malondialdehyde, were measured...
May 16, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28511427/role-of-omega-3-fatty-acids-on-lipid-profile-in-diabetic-dyslipidaemia-single-blind-randomised-clinical-trial
#8
Shaylika Chauhan, Hanish Kodali, Jawad Noor, Karuna Ramteke, Vidisha Gawai
INTRODUCTION: Diabetic dyslipidaemia is characterised by hypertriglyceridaemia, low High Density Lipoprotein (HDL), postprandial lipimea, small and dense LDL particles is considered to be a major predisposing factor for various macrovascular complications. Omega-3 fatty acids are fish oil derivative introduced in the market for dyslipidaemia associated with increased triglyceride level. AIM: To study the effect of omega-3 fatty acids on lipid profile in Type II diabetes patients...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28506805/hdl-abnormalities-in-familial-hypercholesterolemia-focus-on-biological-functions
#9
REVIEW
Shiva Ganjali, Amir Abbas Momtazi, Maciej Banach, Petri T Kovanen, Evan A Stein, Amirhossein Sahebkar
Although a selective strong elevation in the plasma level of low-density lipoprotein (LDL) cholesterol is the hallmark of familial hypercholesterolemia (FH), also other plasma lipoprotein and lipid subspecies are changed in these patients. Several studies in FH patients have pointed to the qualitative abnormalities of high-density lipoprotein (HDL) particles, including their triglyceride and sphingomyelin enrichment, reduced capacity to promote cholesterol efflux from macrophages, impaired anti-inflammatory and anti-oxidant activities, and reduced plasma levels of miRs regulating HDL-dependent cholesterol efflux from macrophage foam cells, typical of atherosclerotic lesions...
May 12, 2017: Progress in Lipid Research
https://www.readbyqxmd.com/read/28502513/relationship-between-noninvasive-scores-of-nonalcoholic-fatty-liver-disease-and-nuclear-magnetic-resonance-lipoprotein-abnormalities-a-focus-on-atherogenic-dyslipidemia
#10
Antonio J Amor, Montserrat Pinyol, Elsa Solà, Marta Catalan, Montserrat Cofán, Zoe Herreras, Nuria Amigó, Rosa Gilabert, Aleix Sala-Vila, Emilio Ros, Emilio Ortega
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is an emerging, highly prevalent, cardiovascular risk factor, and lipoprotein proatherogenic disturbances likely explain a large part of this risk. However, information regarding associations between detailed nuclear magnetic resonance (NMR) lipoprotein changes and noninvasive NAFLD scores is lacking. OBJECTIVE: The objective of the study was to investigate the NMR-assessed atherogenic lipoprotein profile according to noninvasive NAFLD status...
March 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28498145/brief-report-progression-of-atherosclerosis-in-hiv-infected-individuals-prospective-data-from-an-asian-cohort
#11
Grace Lui, Ronald C W Ma, Ping Chook, Chun-Kwok Wong, Claudia H T Tam, Michael H M Chan, Shui-Shan Lee, Rity Y K Wong, Catherine S K Cheung, Kin-Wing Choi, Ping-Chung Leung, Ka-Hing Wong, Kenny C W Chan, Nelson Lee
BACKGROUND: The magnitude and risk factors of progression of atherosclerosis in Asian HIV-infected individuals were unknown. This study aimed to evaluate: (1) the rate of progression of atherosclerosis in HIV-infected individuals, and (2) metabolic and inflammatory parameters that may predict atherosclerosis progression in HIV-infected individuals in an Asian cohort. SETTING: A prospective, longitudinal study was performed among adults attending an HIV Metabolic clinic in Hong Kong...
June 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28494833/impact-of-smoking-status-on-lipoprotein-subfractions-data-from-an-untreated-chinese-cohort
#12
Xi Zhao, Hui Wen Zhang, Yan Zhang, Sha Li, Rui Xia Xu, Jing Sun, Cheng Gang Zhu, Na Qiong Wu, Ying Gao, Yuan Lin Guo, Geng Liu, Qian Dong, Jian Jun Li
OBJECTIVE: Cigarette smoking is one of the established risk factors of atherosclerotic cardiovascular disease, however, its impact on lipids is not completely understood, especially in the Chinese population. Therefore, this study evaluated the impact of smoking status (non, former, and current smoking) on the distribution of lipoprotein subfractions in untreated patients with angina-like chest pain. METHODS: A total of 877 patients were consecutively enrolled and divided into nonsmoking (n = 518), former smoking (n = 103), and current smoking (n = 256) groups...
April 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28488685/effect-of-diets-rich-in-either-saturated-fat-or-n-6-polyunsaturated-fatty-acids-and-supplemented-with-long-chain-n-3-polyunsaturated-fatty-acids-on-plasma-lipoprotein-profiles
#13
C B Dias, N Amigo, L G Wood, X Correig, M L Garg
BACKGROUND/OBJECTIVES: Abnormalities in lipoprotein profiles (size, distribution and concentration) play an important role in the pathobiology of atherosclerosis and coronary artery disease. Dietary fat, among other factors, has been demonstrated to modulate lipoprotein profiles. We aimed to investigate if background dietary fat (saturated, SFA versus omega-6 polyunsaturated fatty acids, n-6PUFA) was a determinant of the effects of LCn-3PUFA supplementation on lipoprotein profiles. SUBJECTS/METHODS: A randomized controlled clinical intervention trial in a parallel design was conducted...
May 10, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28475941/mutational-analysis-and-genotype-phenotype-relation-in-familial-hypercholesterolemia-the-safeheart-registry
#14
Mafalda Bourbon, Ana Catarina Alves, Rodrigo Alonso, Nelva Mata, Pedro Aguiar, Teresa Padró, Pedro Mata
BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is an autosomal dominant disease of cholesterol metabolism that confers an increased risk of premature atherosclerotic cardiovascular disease (ASCVD). Therefore, early identification and treatment of these patients can improve prognosis and reduce the burden of cardiovascular mortality. The aim of this work was to perform the mutational analysis of the SAFEHEART (Spanish Familial Hypercholesterolaemia Cohort Study) registry. METHODS: The study recruited 2938 individuals with genetic diagnosis of FH belonging to 775 families...
April 6, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28472106/cardiometabolic-risk-factors-and-health-behaviors-in-family-caregivers
#15
Alyson Ross, Robert Shamburek, Leslie Wehrlen, Stephen D Klagholz, Li Yang, Elyssa Stoops, Sharon L Flynn, Alan T Remaley, Karel Pacak, Nonniekaye Shelburne, Margaret F Bevans
The purpose of this study was to compare components of cardiometabolic risk and health behaviors of 20 family caregivers of allogeneic hematopoietic stem cell transplant patients to those of age, gender, and race/ethnicity-matched controls. A prospective, repeated measures design was used to compare cardiometabolic risk and health behaviors in caregivers and controls at three time-points: pre-transplantation, discharge, and six weeks post-discharge. Measures included components of metabolic syndrome, Reynolds Risk Score, NMR serum lipoprotein particle analyses, and the Health-Promoting Lifestyle Profile II (HPLP-II)...
2017: PloS One
https://www.readbyqxmd.com/read/28461157/cholesterol-delivery-to-the-adrenal-glands-estimated-by-adrenal-venous-sampling-an-in%C3%A2-vivo-model-to-determine-the-contribution-of-circulating-lipoproteins-to-steroidogenesis-in-humans
#16
Edward Buitenwerf, Robin P F Dullaart, Anneke C Muller Kobold, Thera P Links, Wim J Sluiter, Margery A Connelly, Michiel N Kerstens
BACKGROUND: Cholesterol, required for adrenal steroid hormone synthesis, is at least in part derived from circulating lipoproteins. The contribution of high-density lipoproteins (HDL) and low-density lipoproteins (LDL) to adrenal steroidogenesis in humans is unclear. OBJECTIVE: The aim of the study was to determine the extent to which HDL and LDL are taken up by the adrenal glands using samples obtained during adrenal venous sampling (AVS). METHODS: AVS was successfully performed in 23 patients with primary aldosteronism...
April 5, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28460374/ldl-particle-number-and-size-and-cardiovascular-risk-anything-new-under-the-sun
#17
Janie Allaire, Cécile Vors, Patrick Couture, Benoît Lamarche
PURPOSE OF REVIEW: We provide here an up-to-date perspective on the potential use of LDL particle number and size as complementary risk factors to predict and manage cardiovascular disease (CVD) risk in the clinical realm. RECENT FINDINGS: Studies show that a significant proportion of the population has discordant LDL particle number and cholesterol indices [non-HDL cholesterol (HDL-C)]. Data also show that risk prediction may be improved when using information on LDL particle number in patients with discordant particle number and cholesterol data...
June 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28450679/the-combination-therapy-of-fenofibrate-and-ezetimibe-improved-lipid-profile-and-vascular-function-compared-with-statins-in-patients-with-type-2-diabetes
#18
Atsushi Shinnakasu, Kiyoaki Yamamoto, Mihoko Kurano, Hiroshi Arimura, Aiko Arimura, Akira Kikuti, Hiroshi Hashiguchi, Takahisa Deguti, Yoshihiko Nishio
AIM: Elevated level of serum triglyceride (TG) is a characteristic of type 2 diabetes. We evaluated the clinical significance of intervention for the serum TG levels in the fasting and postprandial states in patients with type 2 diabetes. METHODS: Fifty patients with type 2 diabetes, treated with statins, were selected and divided into two groups. One group was treated with a combination of fenofibrate and ezetimibe (F/E group) and the other group with statins (statin group) for 12 weeks...
April 27, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28450350/cholesterol-efflux-capacity-hdl-particle-number-and-incident-cardiovascular-events-an-analysis-from-the-jupiter-trial-justification-for-the-use-of-statins-in-prevention-an-intervention-trial-evaluating-rosuvastatin
#19
Amit V Khera, Olga Demler, Steve J Adelman, Heidi L Collins, Robert J Glynn, Paul M Ridker, Daniel J Rader, Samia Mora
Background -Recent failures of drugs that raised high-density lipoprotein (HDL) cholesterol levels to reduce cardiovascular events in clinical trials have led to increased interest in alternative indices of HDL quality, such as cholesterol efflux capacity, and HDL quantity, such as HDL particle number. However, no studies have directly compared these metrics in a contemporary population that includes potent statin therapy and low LDL cholesterol. Methods -HDL cholesterol levels, apolipoprotein A-I (apoA-I), cholesterol efflux capacity, and HDL particle number were assessed at baseline and 12 months in a nested case-control study of the JUPITER trial, a randomized primary prevention trial that compared rosuvastatin treatment to placebo in individuals with normal LDL cholesterol but increased C-reactive protein levels...
April 27, 2017: Circulation
https://www.readbyqxmd.com/read/28447439/lipid-abnormalities-in-type-2-diabetes-mellitus-patients-with-overt-nephropathy
#20
Sabitha Palazhy, Vijay Viswanathan
BACKGROUND: Diabetic nephropathy is a major complication of diabetes and an established risk factor for cardiovascular events. Lipid abnormalities occur in patients with diabetic nephropathy, which further increase their risk for cardiovascular events. We compared the degree of dyslipidemia among type 2 diabetes mellitus (T2DM) subjects with and without nephropathy and analyzed the factors associated with nephropathy among them. METHODS: In this retrospective study, T2DM patients with overt nephropathy were enrolled in the study group (n=89) and without nephropathy were enrolled in the control group (n=92)...
April 2017: Diabetes & Metabolism Journal
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