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https://www.readbyqxmd.com/read/29146748/stable-isotope-kinetic-study-of-apom-apolipoprotein-m
#1
Mikaël Croyal, Stéphanie Billon-Crossouard, Sophie Goulitquer, Audrey Aguesse, Luis León, Fanta Fall, Maud Chétiveaux, Thomas Moyon, Valentin Blanchard, Khadija Ouguerram, Gilles Lambert, Estelle Nobécourt, Michel Krempf
OBJECTIVE: ApoM (apolipoprotein M) binds primarily to high-density lipoprotein before to be exchanged with apoB (apolipoprotein B)-containing lipoproteins. Low-density lipoprotein (LDL) receptor-mediated clearance of apoB-containing particles could influence plasma apoM kinetics and decrease its antiatherogenic properties. In humans, we aimed to describe the interaction of apoM kinetics with other components of lipid metabolism to better define its potential benefit on atherosclerosis...
November 16, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29141072/association-of-cetp-gene-variants-with-risk-for-vascular-and-nonvascular-diseases-among-chinese-adults
#2
Iona Y Millwood, Derrick A Bennett, Michael V Holmes, Ruth Boxall, Yu Guo, Zheng Bian, Ling Yang, Sam Sansome, Yiping Chen, Huaidong Du, Canqing Yu, Alex Hacker, Dermot F Reilly, Yunlong Tan, Michael R Hill, Junshi Chen, Richard Peto, Hongbing Shen, Rory Collins, Robert Clarke, Liming Li, Robin G Walters, Zhengming Chen
Importance: Increasing levels of high-density lipoprotein (HDL) cholesterol through pharmacologic inhibition of cholesteryl ester transfer protein (CETP) is a potentially important strategy for prevention and treatment of cardiovascular disease (CVD). Objective: To use genetic variants in the CETP gene to assess potential risks and benefits of lifelong lower CETP activity on CVD and other outcomes. Design, Setting, and Participants: This prospective biobank study included 151 217 individuals aged 30 to 79 years who were enrolled from 5 urban and 5 rural areas of China from June 25, 2004, through July 15, 2008...
November 15, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29104991/biomimetics-reconstitution-of-low-density-lipoprotein-for-targeted-drug-delivery-and-related-theranostic-applications
#3
Chunlei Zhu, Younan Xia
Low-density lipoprotein (LDL), one of the four major groups of lipoproteins for lipid transport in vivo, is emerging as an attractive carrier for the targeted delivery of theranostic agents. In contrast to the synthetic systems, LDL particles are intrinsically biocompatible and biodegradable, together with reduced immunogenicity and natural capabilities to target cancerous cells and to escape from the recognition and elimination by the reticuloendothelial system. Enticed by these attributes, a number of strategies have been developed for reconstituting LDL particles, including conjugation to the apolipoprotein, insertion into the phospholipid layer, and loading into the core...
November 6, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/29102496/plasma-inducible-degrader-of-the-ldlr-soluble-low-density-lipoprotein-receptor-and-proprotein-convertase-subtilisin-kexin-type-9-levels-as-potential-biomarkers-of-familial-hypercholesterolemia-in-children
#4
Josefa Girona, Cèlia Rodríguez-Borjabad, Daiana Ibarretxe, Mercedes Heras, Nuria Amigo, Albert Feliu, Luis Masana, Nuria Plana
BACKGROUND: Familial hypercholesterolemia (FH) in children is under-detected. Plasma biomarkers associated with low-density lipoprotein receptor (LDLR) function could help identifying FH children. OBJECTIVES: We aim to assess the clinical value of inducible degrader of the LDLR (IDOL), soluble LDLR (sLDLR), and proprotein convertase subtilisin/kexin type 9 (PCSK9) plasma concentrations in children with FH compared with control children (CCh). METHODS: This was a cross-sectional study performed in a Lipid Unit from a University hospital...
October 12, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29096867/the-efficacy-of-anti-pcsk9-antibodies-results-from-recent-trials
#5
Ioanna Gouni-Berthold
The serine protease proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the low-density lipoprotein (LDL) receptor (LDLR) and directs it to the lysosome for degradation. This results in decreased numbers of LDLR available on the cell surface to bind LDL particles and remove them from the circulation and a subsequent increase in circulating LDL-cholesterol (LDL-C) concentrations. Since the role PCSK9 plays in LDL-C metabolism has been discovered in 2003, there have been major efforts in finding efficient and safe methods to inhibit it...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29073573/exposure-to-traffic-generated-air-pollutants-mediates-alterations-in-brain-microvascular-integrity-in-wildtype-mice-on-a-high-fat-diet
#6
Usa Suwannasual, JoAnn Lucero, Jacob D McDonald, Amie K Lund
Air pollution-exposure is associated with detrimental outcomes in the central nervous system (CNS) such as cerebrovascular disorders, including stroke, and neurodegenerative diseases. While the mechanisms of these CNS-related outcomes involved have not been fully elucidated, exposure to traffic-generated air pollutants has been associated with altered blood brain barrier (BBB) integrity and permeability. The current study investigated whether inhalation exposure to mixed vehicle emissions (MVE) alters cerebral microvascular integrity in healthy 3 mo old C57BL/6 mice, as well as whether exposure-mediated effects were exacerbated by a high-fat (HF) vs...
October 23, 2017: Environmental Research
https://www.readbyqxmd.com/read/29069931/synthetic-lipoprotein-as-nano-material-vehicle-in-the-targeted-drug-delivery
#7
Xueqin Zhang, Gangliang Huang
High-density lipoprotein (HDL) and low-density lipoprotein (LDL), as human endogenous lipoprotein particles, have low toxicity, high selectivity, and good safety. They can avoid the recognition and clearance of human reticuloendothelial system. These synthetic lipoproteins (sLPs) have been attracted extensive attention as the nanovectors for tumor-targeted drug and gene delivery. Herein, recent advances in the field of anticancer based on these two lipid proteins and recombinant lipoproteins (rLPs) as target delivery vectors were analyzed and discussed...
December 2017: Drug Delivery
https://www.readbyqxmd.com/read/29067238/lipid-disorders-in-patients-with-renal-failure-role-in-cardiovascular-events-and-progression-of-chronic-kidney-disease
#8
REVIEW
Luca Visconti, Salvatore Benvenga, Antonio Lacquaniti, Valeria Cernaro, Annamaria Bruzzese, Giovanni Conti, Michele Buemi, Domenico Santoro
The spectrum of lipid disorders in chronic kidney disease (CKD) is usually characterized by high triglycerides and reduced high dense lipoprotein (HDL), associated with normal or slightly reduced low dense lipoprotein (LDL)-cholesterol. This dyslipidemia is associated with an increased risk for atherosclerotic cardiovascular disease. Keys for the cardiovascular risk reduction in these patients are lowering the number and modifying the composition of the cholesterol-carrying atherogenic lipoprotein particles...
December 2016: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29067237/ipragliflozin-lowers-small-dense-low-density-lipoprotein-cholesterol-levels-in-japanese-patients-with-type-2-diabetes-mellitus
#9
Yukihiro Bando, Hitomi Tohyama, Keiko Aoki, Hideo Kanehara, Azusa Hisada, Kazuhiro Okafuji, Daisyu Toya
AIMS: This preliminary randomized, parallel-group comparative study evaluated the efficacy of ipragliflozin for reduction of small dense low-density lipoprotein cholesterol (sd LDL-C) levels in Japanese patients with type 2 diabetes mellitus (T2DM). METHODS: Sixty-two patients with T2DM (age, 56 ± 8 years; hemoglobin A1c levels, 8.1 ± 0.9%; BMI, 27.5 ± 3.3 kg/m(2)) were randomly assigned in a 2:1 ratio to receive ipragliflozin (50 mg/day) (treatment group; n = 40) or continued treatment (control group; n = 22) for 12 weeks...
December 2016: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29037448/effects-of-proprotein-convertase-subtilisin-kexin-type-9-pcsk9-inhibition-with-bococizumab-on-lipoprotein-particles-in-hypercholesterolemic-subjects
#10
Hong Wan, Barry Gumbiner, Tenshang Joh, Tom Riel, Chandrasekhar Udata, Philippe Forgues, Pamela D Garzone
PURPOSE: Monoclonal antibody inhibitors of proprotein convertase subtilisin/kexin type 9 (PCSK9) elicit significant reductions in serum LDL-C levels. However, little is known about their effects on lipoprotein particles. The purpose of this analysis was to evaluate the effect of PCSK9 inhibition with bococizumab (RN316/PF-04950615), a humanized monoclonal antibody to PCSK9, on LDL, VLDL, and HDL particle concentration and size in hypercholesterolemic subjects. METHODS: Data from 3 double-blind, placebo-controlled, randomized studies were analyzed...
October 13, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/29035931/bioactive-lipids-in-osteoarthritis-risk-or-benefit
#11
Andreea Ioan-Facsinay, Margreet Kloppenburg
PURPOSE OF REVIEW: Lipids are bioactive molecules that can affect several biological functions. Technological developments allowing identification of novel lipid species and the study of their function have led to a significant advance in our understanding of lipid biology and their involvement in various diseases. This is particularly relevant for diseases associated with obesity in which lipid accumulation could be involved in pathogenesis. Here, we focus on osteoarthritis, a chronic joint disease aggravated by obesity, and will present the latest findings regarding the involvement of lipids in disease development and progression...
October 13, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29029165/depicting-new-pharmacological-strategies-for-familial-hypercholesterolaemia-involving-lipoprotein-a
#12
Alpo Vuorio, Gerald F Watts, Petri T Kovanen
Approximately 35 million people worldwide suffer from heterozygous familial hypercholesterolaemia (HeFH), a condition characterized by genetically determined life-long elevation of plasma low-density lipoprotein cholesterol (LDL-C). One in three of these patients also inherit an elevated plasma concentration of lipoprotein (a) [Lp(a)], a lipoprotein particle with atherogenic, inflammatory and prothrombotic properties. Accordingly, the combination of high plasma LDL-C and Lp(a) can markedly accelerate premature atherosclerotic cardiovascular disease (ASCVD)...
October 3, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28989873/effect-of-metformin-sustained-release-therapy-on-low-density-lipoprotein-size-and-adiponectin-in-the-south-indian-women-with-polycystic-ovary-syndrome
#13
D Rama Nagendra Kumar, Krishna G Seshadri, Monna Pandurangi
OBJECTIVES: The aim of the study is to compare surrogate markers of cardiovascular disease (CVD) risk, such as adiponectin (APN) levels and low-density lipoprotein (LDL) size, before and after sustained release metformin (Met-SR) therapy in women with polycystic ovarian syndrome (PCOS). METHODS: Sixty women with PCOS and sixty age-matched controls in the age group 18-45 years were recruited after obtaining informed consent. Women with PCOS were initiated on Met-SR 1 g orally, which was increased to 1...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28987777/palestinian-arab-ethnicity-is-associated-with-an-adverse-metabolic-phenotype
#14
Ram Weiss, Hisham Nassar, Ronit Sinnreich, Wiessam Abu-Ahmad, James Otvos, Jeremy D Kark
Urban-dwelling Palestinians have been shown to have higher cardiovascular morbidity and mortality and prevalence of diabetes than urban Israelis. Inflammation is implicated in the etiology of these conditions. We hypothesized that increased inflammatory activation, manifested as increased GlycA, a novel biomarker of global inflammation, would be evident in Palestinians. We compared GlycA concentrations between Palestinians and Israelis and assessed the associations of GlycA with anthropometric, health behavioral and clinical variables in a sample of 1674 Palestinians and Israelis aged 25-74, residing in Jerusalem...
October 4, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28978905/early-progression-of-xanthogranulomatous-pyelonephritis-in-children-might-be-dependent-on-vimentin-expression
#15
Danuta Ostalska-Nowicka, Katarzyna Mackowiak-Lewandowicz, Aneta Konwerska, Jacek Zachwieja
BACKGROUND Xanthogranulomatous pyelonephritis (XP) is an extremely rare, severe, atypical form of chronic renal parenchymal inflammation accompanied by hydronephrosis and/or urolithiasis. The pathomechanism of XP is not yet fully understood. Microscopically, XP is indicated by the presence of multinucleated giant cells and lipid-laden macrophages, as well as inflammatory infiltration and intensive renal fibrosis. The lipid accumulation in kidney parenchyma may be secondary to the altered flow of low-density lipoprotein (LDL)-derived cholesterol particles inside the affected cells...
October 5, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28971099/effect-of-theobromine-consumption-on-serum-lipoprotein-profiles-in-apparently-healthy-humans-with-low-hdl-cholesterol-concentrations
#16
Doris M Jacobs, Lotte Smolders, Yuguang Lin, Niels de Roo, Elke A Trautwein, John van Duynhoven, Ronald P Mensink, Jogchum Plat, Velitchka V Mihaleva
Scope: Theobromine is a major active compound in cocoa with allegedly beneficial effect on high-density-lipoprotein-cholesterol (HDL-CH). We have investigated the effect of theobromine (TB) consumption on the concentrations of triglyceride (TG) and cholesterol (CH) in various lipoprotein (LP) subclasses. Methods: In a randomized, double-blind, placebo-controlled, cross-over study, 44 apparently healthy women and men (age: 60 ± 6 years, BMI: 29 ± 3 kg/m(2)) with low baseline HDL-CH concentrations consumed a drink supplemented with 500 mg/d theobromine for 4 weeks...
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/28970916/tailored-theranostic-apolipoprotein-e3-porphyrin-lipid-nanoparticles-target-glioblastoma
#17
M A Rajora, L Ding, M Valic, W Jiang, M Overchuk, J Chen, G Zheng
The development of curative glioblastoma treatments and tumour-specific contrast agents that can overcome the blood-brain barrier (BBB) and infiltrative tumour morphology remains a challenge. Apolipoprotein E3 (apoE3) is a high density lipoprotein apolipoprotein that chaperones the transcytosis of nanoparticles across the BBB, and displays high-affinity binding with the low density lipoprotein receptor (LDLR), a cell-surface receptor overexpressed by glioblastoma cells. This LDLR overexpression and apoE3 binding capacity was exploited for the development of glioblastoma-targeted porphyrin-lipid apoE3 lipid nanoparticles (pyE-LNs) with intrinsic theranostic properties...
August 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28970592/a-therapeutic-peptide-vaccine-against-pcsk9
#18
Yajie Pan, Yanzhao Zhou, Hailang Wu, Xiao Chen, Xiajun Hu, Hongrong Zhang, Zihua Zhou, Zhihua Qiu, Yuhua Liao
Vaccination provides a promising approach for treatment of hypercholesterolemia and improvement in compliance. In this study, the appropriate virus-like particle (VLP)-peptide vaccines targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) were screened. The screening criteria of target peptides were as follows: (1) located in catalytic domain of PCSK9, or regulating the binding of PCSK9 and LDL receptors (LDLR); (2) having low/no-similarity when matched with the host proteome; (3) possessing ideal antigenicity and hydrophilicity; (4) including the functional mutation site of PCSK9...
October 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28969633/relation-between-low-density-lipoprotein-cholesterol-apolipoprotein-b-ratio-and-triglyceride-rich-lipoproteins-in-patients-with-coronary-artery-disease-and-type-2-diabetes-mellitus-a-cross-sectional-study
#19
Shigemasa Tani, Tsukasa Yagi, Wataru Atsumi, Kenji Kawauchi, Rei Matsuo, Atsushi Hirayama
BACKGROUND: The low-density lipoprotein cholesterol/apolipoprotein B (LDL-C/apoB) ratio has conventionally been used as an index of the LDL-particle size. Smaller LDL-particle size is associated with triglyceride (TG) metabolism disorders, often leading to atherogenesis. We investigated the association between the LDL-C/apoB ratio and TG metabolism in coronary artery disease (CAD) patients with diabetes mellitus (DM). METHODS: In the cross-sectional study, the LDL-C/apoB ratio, which provides an estimate of the LDL-particle size, was calculated in 684 consecutive patients with one additional risk factor...
October 2, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28963918/comprehensive-lipid-and-metabolite-profiling-of-children-with-and-without-familial-hypercholesterolemia-a-cross-sectional-study
#20
Jacob J Christensen, Stine M Ulven, Kjetil Retterstøl, Ingunn Narverud, Martin P Bogsrud, Tore Henriksen, Jens Bollerslev, Bente Halvorsen, Pål Aukrust, Kirsten B Holven
BACKGROUND AND AIMS: Individuals with familial hypercholesterolemia (FH) have elevated low-density lipoprotein cholesterol (LDL-C), accelerated atherosclerosis, and premature cardiovascular disease. Whereas children with lifestyle-induced dyslipidemias often present with complex lipid abnormalities, children with FH have isolated hypercholesterolemia. However, to the best of our knowledge, a comprehensive profiling of FH children is lacking. Therefore, we aimed to characterize the lipid-related and metabolic alterations associated with elevated LDL-C in children with FH and healthy children...
November 2017: Atherosclerosis
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