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https://www.readbyqxmd.com/read/27903361/-evaluation-of-health-effect-among-occupational-population-exposed-to-nano-titanium-dioxide-a-cross-sectional-study
#1
H D Xu, J W Zhou, S C Tang, F L Kong, X W Li, Z L Shen, L Yan, Z J Chen, L Zhao, G Jia, J Zhang
Objective: To characterize the health effects of nano-titanium dioxide exposure in an occupational cohort. Methods: Eighty-five male employees of a nano-titanium dioxide manufacturing enterprise in Shandong Province were evaluated in September 2014. Forty-four were exposed to nano-titanium dioxide (exposure group), and 41 were not exposed to nano-titanium dioxide (control group). We collected employees' basic information, smoking and drinking history, previous medical history, family history, and occupational history...
November 6, 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/27900865/-treatment-of-dyslipidemia-is-here-still-place-for-cetp-inhibitors
#2
Ján Murín, Miroslav Pernický, Soňa Kiňová
In the treatment of dyslipidemias about 5-6 years back a new class of drugs emerged, CETP (cholesteryl ester transfer protein)-inhibitors. Their benefit was due to an increase of HDL-cholesterol (HDL-C) serum levels. This treatment mode was supported by epidemiological and clinical studies, as people with high serum HDL-C levels suffered less from cardiovascular (CV) events. Three studies with CETP inhibitors (ILLUMINATE with torcetrapib, dal-OUTCOMES with dalcetrapib and ACCELERATE with evacetrapib) were unfortunately negative, and torcetrapib was even harmful to patients due to an increase of aldosterone serum levels...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27898070/lipids-lipoprotein-distribution-and-depressive-symptoms-the-multi-ethnic-study-of-atherosclerosis
#3
K L Ong, M J Morris, R L McClelland, J Maniam, M A Allison, K-A Rye
Previous studies suggest lower concentrations of total and high-density lipoprotein (HDL) cholesterol to be predictive of depression. We therefore investigated the relationship of lipids and lipoprotein distribution with elevated depressive symptoms (EDS) in healthy men and women from the Multi-Ethnic Study of Atherosclerosis (MESA). Participants were followed up over a 9.5-year period. EDS were defined as a Center for Epidemiological Studies Depression (CES-D) score ⩾16 and/or use of antidepressant drugs...
November 29, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27888906/-lipid-lowering-drugs-and-pcsk9
#4
Jesús Millán Núñez-Cortés, José M Mostaza Prieto
PCSK9 is a protease, synthesized mainly in the liver, which promotes the hepatic degradation of the LDL receptor and consequently decreases LDL receptor density and clearance of LDL particles. Statins inhibit HMG-CoA-reductase activity, an enzyme that catalyses an important step in hepatic cholesterol biosynthesis. The decrease of the hepatic intracellular cholesterol pool produced by these drugs upregulates the activity of the SREBP2 transcription factor, which subsequently stimulates the expression of the LDL receptor gene, an effect that is followed by an increase in the serum concentration of PCSK9...
May 2016: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/27887691/cost-effectiveness-of-achieving-targets-of-low-density-lipoprotein-particle-number-versus-low-density-lipoprotein-cholesterol-level
#5
Michael Grabner, Deborah A Winegar, Rajeshwari S Punekar, Ralph A Quimbo, Mark J Cziraky, William C Cromwell
A recent analysis of a commercially insured US population found fewer cardiovascular disease (CVD) events in high-risk patients attaining low levels of low-density lipoprotein (LDL), as measured by LDL particle number (LDL-P) versus low LDL cholesterol (LDL-C). Here, we investigated the cost effectiveness of LDL-lowering therapy guided by LDL-P. Patients were selected from the HealthCore Integrated Research Database and followed for 12 to 36 months. Patients who achieved LDL-P <1,000 nmol/l were placed into the LDL-P cohort, whereas those without LDL-P tests, but who achieved LDL-C <100 mg/dl, were placed into the LDL-C cohort...
October 31, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27886175/statistical-power-considerations-in-genotype-based-recall-randomized-controlled-trials
#6
Naeimeh Atabaki-Pasdar, Mattias Ohlsson, Dmitry Shungin, Azra Kurbasic, Erik Ingelsson, Ewan R Pearson, Ashfaq Ali, Paul W Franks
Randomized controlled trials (RCT) are often underpowered for validating gene-treatment interactions. Using published data from the Diabetes Prevention Program (DPP), we examined power in conventional and genotype-based recall (GBR) trials. We calculated sample size and statistical power for gene-metformin interactions (vs. placebo) using incidence rates, gene-drug interaction effect estimates and allele frequencies reported in the DPP for the rs8065082 SLC47A1 variant, a metformin transported encoding locus...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27871290/heterozygous-connexin-50-mutation-affects-metabolic-syndrome-attributes-in-spontaneously-hypertensive-rat
#7
Ondřej Šeda, Drahomíra Křenová, Olena Oliyarnyk, Lucie Šedová, Michaela Krupková, František Liška, Blanka Chylíková, Ludmila Kazdová, Vladimír Křen
BACKGROUND: Several members of connexin family of transmembrane proteins were previously implicated in distinct metabolic conditions. In this study we aimed to determine the effects of complete and heterozygous form of connexin50 gene (Gja8) mutation L7Q on metabolic profile and oxidative stress parameters in spontaneously hypertensive inbred rat strain (SHR). METHODS: Adult, standard chow-fed male rats of SHR, heterozygous SHR-Dca+/- and SHR-Dca-/- coisogenic strains were used...
November 21, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27866534/-dihydrotestosterone-inhibits-foam-cell-formation-via-a-lectin-like-ox-low-density-lipoprotein-receptor-mediated-mechanism-in-j774-1-cell-line
#8
Y Qiu, H D Hu, B Q Hu, X Y Chen, P Y Xu, L Cui, P Li, C Liu, L Li
Objective: To investigate the effect of dihydrotestosterone (DHT) on lectin-like ox- low-density lipoprotein (LDL) receptor(LOX-1)expression and foam cell formation in the female macrophage cell line J774.1. Methods: In cultured J774.1 cells, after pretreated with DHT at concentrations of 1×10(-9) mol/L and 1×10(-8) mol/L, ox-LDL-induced LOX-1 expression and foam cell formation were investigated by quantitative real-time PCR, Western blotting, and oil-red O staining. Results: DHT at concentrations of 1×10(-9) mol/L and 1×10(-8) mol/L inhibited ox-LDL-induced LOX-1 mRNA (2...
November 15, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27853332/effects-of-subcutaneous-injection-mno2-micro-and-nanoparticles-on-blood-glucose-level-and-lipid-profile-in-rat
#9
Zahra Mousavi, Majid Hassanpourezatti, Parvaneh Najafizadeh, Shiva Rezagholian, Mohammad Safi Rhamanifar, Nahid Nosrati
BACKGROUND: The use of nanotechnology has led to rapid growth in various areas. Thus, health and safety issues of nanoparticles (NPs) should be promptly addressed. Manganese oxide (MnO2) nanoparticles (NPs) are typically used for biomedical and industrial applications. However, characterizing the potential human health effects of MnO2 NPs is required before fully exploiting these materials. The aim of this study was to investigate the toxicity of MnO2 micro- and nanoparticles on blood glucose level and lipid profile in male Wistar rats...
November 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27845214/fabrication-of-self-assembled-chitosan-dispersed-ldl-nanoparticles-for-drug-delivery-with-a-one-step-green-method
#10
Jing Tian, Shasha Xu, Hongbing Deng, Xinxing Song, Xiujuan Li, Jiajia Chen, Feng Cao, Bin Li
Self-assembled nanoparticles (NPs) composed of chitosan (CS) and low density lipoprotein (LDL) of hen eggs were prepared by a one-step green synthesis of mixing CS solution and LDL suspension. The formulated CS-LDL NPs were then applied to encapsulate doxorubicin hydrochloride (DOX) with the encapsulation efficiency of 51.7%. The average particle size and ζ-potential of DOX-loaded CS-LDL NPs (CS-LDL-DOX NPs) were 179nm and +48.3mV, respectively. The encapsulated DOX showed less cytotoxicity than free DOX after 24-h incubation with gastric cancer SGC7901 cells, which may be due to extended release...
November 11, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27833702/serum-lipoprotein-a-levels-in-black-south-african-type-2-diabetes-mellitus-patients
#11
Jim Joseph, Farzana Ganjifrockwala, Grace George
Lipoprotein (a) (Lp(a)) which is a low-density lipoprotein-like particle containing apo(a) is considered as an emergent cardiovascular risk factor. Type 2 diabetes mellitus (T2DM) is associated with a two- to threefold increase in the risk of cardiovascular disease (CVD). The aim of this study was to investigate the levels of Lp(a) in Black South African T2DM patients and its association with other metabolic factors. 67 T2DM patients and 48 healthy control participants were recruited for the cross-sectional study...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27829582/postprandial-hyperlipidemia-and-remnant-lipoproteins
#12
Daisaku Masuda, Shizuya Yamashita
Fasting hypertriglyceridemia is positively associated with the morbidity of coronary heart disease (CHD), and postprandial (non-fasting) hypertriglyceridemia is also correlated with the risk status for CHD, which is related to the increase in chylomicron (CM) remnant lipoproteins produced from the intestine. CM remnant particles, as well as oxidized low density lipoprotein (LDL) or very low density lipoprotein (VLDL) remnants, are highly atherogenic and act by enhancing systemic inflammation, platelet activation, coagulation, thrombus formation, and macrophage foam cell formation...
November 8, 2016: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/27824107/structural-changes-induced-by-acidic-ph-in-human-apolipoprotein-b-100
#13
José A Fernández-Higuero, Asier Benito-Vicente, Aitor Etxebarria, José Carlos G Milicua, Helena Ostolaza, José L R Arrondo, Cesar Martín
Acidification in the endosome causes lipoprotein release by promoting a conformational change in the LDLR allowing its recycling and degradation of LDL. Notwithstanding conformational changes occurring in the LDLR have expanded considerably, structural changes occurring in LDL particles have not been fully explored yet. The objectives of the present work were to study structural changes occurring in apoB100 by infrared spectroscopy (IR) and also LDL size and morphology by dynamic light scattering (DLS) and electron microscopy (EM) at both pH 7...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27816804/persistent-changes-in-lipoprotein-lipids-after-a-single-infusion-of-ascending-doses-of-mdco-216-apoa-imilano-popc-in-healthy-volunteers-and-stable-coronary-artery-disease-patients
#14
Herman J Kempen, Monica Gomaraschi, Sara Simonelli, Laura Calabresi, Matthijs Moerland, James Otvos, Elias Jeyarajah, David Kallend, Peter L J Wijngaard
BACKGROUND AND AIMS: Effects of single ascending doses of MDCO-216 on plasma lipid and lipoprotein levels were assessed in human healthy volunteers and in patients with stable coronary artery disease (CAD). METHODS: MDCO-216 was infused at a single dose of 5, 10, 20, 30 or 40 mg/kg over 2 h and blood was collected at 2, 4, 8, 24, 48, 168 and 720 h after start of infusion (ASOI). Lipoprotein lipids were assessed by FLPC and by 1H NMR. RESULTS: Plasma concentrations of free cholesterol (FC) displayed a rapid and dose-dependent rise, peaking at 8 h, but remaining above baseline until 48 h ASOI, whereas levels of esterified cholesterol (CE) increased at lower doses but not at higher doses, and even decreased below baseline at the highest dose...
October 24, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27809652/liver-fat-and-insulin-sensitivity-define-metabolite-profiles-during-a-glucose-tolerance-test-in-young-adult-twins
#15
Joel T Rämö, Sanna M Kaye, Sakari Jukarainen, Leonie H Bogl, Antti Hakkarainen, Jesper Lundbom, Nina Lundbom, Aila Rissanen, Jaakko Kaprio, Niina Matikainen, Kirsi H Pietiläinen
CONTEXT: The associations of BMI and liver fat (LF) with circulating prandial metabolomic markers are incompletely understood. OBJECTIVE: To characterize circulating metabolite excursions during an oral glucose tolerance test (OGTT), and evaluate whether the metabolomic signatures of BMI-discordance co-associate with LF content. DESIGN, SETTING AND PARTICIPANTS: We measured 80 metabolite parameters by nuclear magnetic resonance, together with glucose and insulin, during a 2-hour OGTT in 64 monozygotic and 73 dizygotic twin pairs (aged 22...
November 3, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27793087/lipoproteins-attenuate-tlr2-and-tlr4-activation-by-bacteria-and-bacterial-ligands-with-differences-in-affinity-and-kinetics
#16
Jeroen van Bergenhenegouwen, Aletta D Kraneveld, Lieke Rutten, Johan Garssen, Arjan P Vos, Anita Hartog
BACKGROUND: The small intestine is a specialized compartment were close interactions take place between host, microbes, food antigens and dietary fatty acids. Dietary fats get absorbed by epithelial cells and processed into a range of lipoprotein particles after which they are basolaterally secreted and collected in the lymphatics. In contrast to the colon, the small intestine is covered only by a thin mucus coat that allows for intimate interactions between host-cells and microbes. Lipoproteins have long been recognized as protective factors in infectious diseases via the neutralization of bacterial toxins like lipopolysaccharides...
October 28, 2016: BMC Immunology
https://www.readbyqxmd.com/read/27789955/carbohydrate-composition-of-circulating-multiple-modified-low-density-lipoprotein
#17
Emile R Zakiev, Igor A Sobenin, Vasily N Sukhorukov, Veronika A Myasoedova, Ekaterina A Ivanova, Alexander N Orekhov
Atherogenic modification of low-density lipoprotein (LDL) plays a crucial role in the pathogenesis of atherosclerosis, as modified LDL, but not native LDL, induces pronounced accumulation of cholesterol and lipids in the arterial wall. It is likely that LDL particles undergo multiple modifications in human plasma: desialylation, changes in size and density, acquisition of negative electric charge, oxidation, and complex formation. In a total LDL preparation isolated from pooled plasma of patients with coronary atherosclerosis and from healthy subjects, two subfractions of LDL could be identified: desialylated LDL bound by a lectin affinity column and normally sialylated (native) LDL that passed through the column...
2016: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/27784733/comprehensive-analysis-of-established-dyslipidemia-associated-loci-in-the-diabetes-prevention-program
#18
Tibor V Varga, Alexandra H Winters, Kathleen A Jablonski, Edward S Horton, Prajakta Khare-Ranade, William C Knowler, Santica M Marcovina, Frida Renström, Karol E Watson, Ronald Goldberg, José C Florez, Toni I Pollin, Paul W Franks
BACKGROUND: -We assessed whether 234 established dyslipidemia-associated loci modify the effects of metformin treatment and lifestyle intervention (vs. placebo control) on lipid and lipid sub-fraction levels in the Diabetes Prevention Program (DPP) randomized controlled trial. METHODS AND RESULTS: -We tested gene-treatment interactions in relation to baseline adjusted follow-up blood lipid concentrations (high and low density lipoprotein cholesterol [HDL-C, LDL-C], total cholesterol, triglycerides) and lipoprotein sub-fraction particle concentrations and size in 2,993 participants with pre-diabetes...
October 26, 2016: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/27776640/a-novel-method-for-serum-lipoprotein-profiling-using-high-performance-capillary-isotachophoresis
#19
Estefanía Moreno-Gordaliza, Sven J van der Lee, Ayşe Demirkan, Cornelia M van Duijn, Johan Kuiper, Petrus W Lindenburg, Thomas Hankemeier
A new capillary isotachophoresis (cITP) method for lipoprotein profiling with superior lipoprotein coverage compared to previous methods has been developed, resolving twice as many lipoprotein species (18 peaks/fractions) in serum or plasma in less than 9.5 min. For this, a novel mixture of 24 spacers, including amino acids, dipeptides and sulfonic acids, was developed and fine-tuned, using predictive software (PeakMaster) and testing of spiked serum samples. Lipoprotein peaks were identified by serum-spiking with reference lipoproteins...
November 9, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27774895/sialidases-therapeutic-and-antiatherogenic-potential
#20
V N Sukhorukov, V P Karagodin, E R Zakiev, A N Orekhov
This review mainly focuses on the medical and biological role of relatively poor studied enzymes known as sialidases. Structure and function of sialic acid, particularly as a component of gangliosides and plasma lipoproteins is described. Among the whole variety of sialidases, trans-sialidase is of special interest, since it is capable of removing sialic acid from the low density lipoprotein (LDL) particles and transferring it to different acceptors in plasma. Desialylation of LDL in turn endow them the capacity to accumulate in the smooth muscle cells of human aortic intima, highlighting the important role of desialylation in atherogenesis...
October 19, 2016: Current Pharmaceutical Design
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