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https://www.readbyqxmd.com/read/28636345/levels-of-organochlorine-pesticides-are-associated-with-amyloid-aggregation-in-apex-avian-brains
#1
Kelly A Heys, Richard F Shore, M Gloria Pereira, Francis Luke Martin
Organochlorine (OC) pesticides pose a significant environmental risk to wildlife and humans and have been associated with Alzheimer's disease (AD). This study aims to spectroscopically analyse brains from free-flying birds and link the results to OC exposure and consequent amyloid aggregation. As long-lived apex predators, predatory birds represent a sentinel species similar to humans. Therefore, the results have implications for both species and may also add to our understanding of the role OC pesticides play in the development of AD...
June 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28633579/-hey-how-s-it-going-the-practical-value-of-assessing-quality-of-life-in-mental-illness
#2
Eric Josiah Tan, Susan Lee Rossell
No abstract text is available yet for this article.
July 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28632744/comparison-between-gastrostomy-feeding-and-self-expandable-metal-stent-insertion-for-patients-with-esophageal-cancer-and-dysphagia
#3
Yang Won Min, Eun Young Jang, Ji Hey Jung, Hyuk Lee, Byung-Hoon Min, Jun Haeng Lee, Poong-Lyul Rhee, Jae J Kim
BACKGROUND: Self-expandable metal stent (SEMS) insertion and percutaneous gastrostomy (PG) feeding are commonly used for patients with esophageal cancer and dysphagia. This study aimed to compare outcomes between SEMS insertion and PG feeding for them. METHODS: We retrospectively analyzed 308 patients with esophageal cancer who underwent fully covered SEMS insertion (stent group) or PG (gastrostomy group) for dysphagia due to tumor. Patients with other causes of dysphagia, such as radiation-induced or postoperative stricture, were excluded from the study...
2017: PloS One
https://www.readbyqxmd.com/read/28632381/molecular-modeling-of-the-interactions-between-carborane-containing-analogs-of-indomethacin-and-cyclooxygenase-2
#4
Menyhárt-Botond Sárosi, Wilma Neumann, Terry P Lybrand, Evamarie Hey-Hawkins
Molecular modeling studies were performed in order to gain insight into the binding mode and interaction of carborane-containing derivatives of indomethacin methyl ester with the cyclooxygenase 2 (COX 2) isoform, and to assess the predictive capability of the computational tools available for studying carboranes, a unique class of pharmacophores. Docking simulations were able to identify the correct binding mode and reproduced the experimental binding affinity trends with encouraging quality. Nevertheless, the docking results needed to be verified through extensive and resource intensive quantum chemical calculations, and the interpretation of the theoretical results would not have been straightforward without the supporting experimental data...
June 20, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28630420/functional-evaluation-of-a-bioartificial-liver-support-system-using-immobilized-hepatocyte-spheroids-in-a-porcine-model-of-acute-liver-failure
#5
Ji-Hyun Lee, Doo-Hoon Lee, Sanghoon Lee, Choon Hyuck David Kwon, Jae-Nam Ryu, Jeong-Kwon Noh, In Keun Jang, Hey-Jung Park, Hee-Hoon Yoon, Jung-Keug Park, Young-Jin Kim, Sung-Koo Kim, Suk-Koo Lee
Bioartificial livers (BAL) may offer acute liver failure (ALF) patients an opportunity for cure without liver transplantation. We evaluated the efficacy of a spheroid-based BAL system, containing aggregates of porcine hepatocytes, in a porcine model of ALF. ALF pigs were divided into three groups. The control group consisted of treatment naïve pigs (n = 5), blank group consisted of pigs that were attached to the BAL system not containing hepatocytes for 12 hours (n = 5) and BAL group consisted of pigs that were attached to the BAL containing hepatocytes for 12 hours (n = 5)...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28627759/vibrational-biospectroscopy-characterises-biochemical-differences-between-cell-types-used-for-toxicological-investigations-and-identifies-alterations-induced-by-environmental-contaminants
#6
Kelly A Heys, Richard F Shore, M Glória Pereira, Francis L Martin
The use of cell-based assays is essential in reducing the number of vertebrates used in the investigation of chemical toxicities and in regulatory toxicology assessment. An important factor in obtaining meaningful results which can be accurately extrapolated is the use of biologically appropriate cell lines. In this preliminary study, ATR-FTIR spectroscopy with multivariate analysis was used to assess the fundamental biomolecular differences between a commonly used cell line, MCF-7 cells, and an environmentally relevant cell line derived from Mallard (Anas platyrhynchos) dermal fibroblasts...
June 19, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28627281/mirroring-meaningful-actions-sensorimotor-learning-modulates-imitation-of-goal-directed-actions
#7
Caroline Catmur, Cecilia Heyes
Imitation is important in the development of social and technological skills throughout the lifespan. Experiments investigating the acquisition and modulation of imitation (and of its proposed neural substrate, the mirror neuron system) have produced evidence that the capacity for imitation depends on associative learning in which connections are formed between sensory and motor representations of actions. However, evidence that the development of imitation depends on associative learning has been found only for non-goal-directed actions...
June 19, 2017: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/28625178/endoscopic-electrocautery-and-fibrin-obliteration-of-an-acutely-complicated-pyriform-fossa-sinus-tract-in-a-septuagenarian
#8
R Heyes, A G Aulakh, R K Lingam, T Tatla
BACKGROUND: Pyriform fossa sinus tracts classically present with neck abscess, recurrent infections and suppurative thyroiditis in children; acute presentation in a geriatric patient is rare. METHODS: Case report and Medline literature review. CASE REPORT: A 79-year-old female presented with a left-sided neck mass and severe odynophagia of 3 days' duration. Magnetic resonance imaging revealed a large-volume, loculated fluid collection extending throughout the deep spaces of the neck on the left, within and around the thyroid gland capsule...
June 19, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28623231/cry6aa1-a-bacillus-thuringiensis-nematocidal-and-insecticidal-toxin-forms-pores-in-planar-lipid-bilayers-at-extremely-low-concentrations-and-without-the-need-of-proteolytic-processing
#9
Eva Fortea, Vincent Lemieux, Léna Potvin, Vimbai Chikwana, Samantha Griffin, Thimothy Hey, David McCaskill, Kenneth Narva, Sek Yee Tan, Xiaoping Xu, Vincent Vachon, Jean-Louis Schwartz
Cry6Aa1 is a Bacillus thuringiensis (Bt) toxin active against nematodes and corn rootworm insects. Its 3-D molecular structure, which has been recently elucidated, is unique among those known for other Bt toxins. Typical three-domain Bt toxins permeabilise receptor-free planar lipid bilayers (PLBs) by forming pores at doses in the 1-50 μg/ml range. Solubilisation and proteolytic activation are necessary steps for PLB permeabilisation. In contrast to other Bt toxins, Cry6Aa1 formed pores in receptor-free bilayers at doses as low as 200 pg/ml in a wide range of pH (5...
June 16, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28611186/success-failure-and-transparency-in-biomarker-based-drug-development-a-case-study-of-cholesteryl-ester-transfer-protein-inhibitors
#10
Spencer Phillips Hey, Jessica M Franklin, Jerry Avorn, Aaron S Kesselheim
BACKGROUND: Although biomarkers are used as surrogate measures for drug targeting and approval and are generally based on plausible biological hypotheses, some are found to not correlate well with clinical outcomes. Over-reliance on inadequately validated biomarkers in drug development can lead to harm to trial subjects and patients and to research waste. To shed greater light on the process and ethics of biomarker-based drug development, we conducted a systematic portfolio analysis of cholesterol ester transfer protein inhibitors, a drug class designed to improve lipid profiles and prevent cardiovascular events...
June 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28609325/to-the-editor
#11
Hwee W D Hey, Nathaniel L W Ng, Chuen S Tan, Dale Fisher, Anupama Vasudevan, Gabriel K P Liu, Joseph Thambiah, Naresh Kumar, Leok L Lau, Hee K Wong, Paul A Tambyah
No abstract text is available yet for this article.
June 15, 2017: Spine
https://www.readbyqxmd.com/read/28609324/results-of-the-2015-scoliosis-research-society-survey-on-single-versus-dual-attending-surgeon-approach-for-adult-spinal-deformity-surgery
#12
Justin K Scheer, Rajiv K Sethi, Lloyd A Hey, Michael O LaGrone, Malla Keefe, Henry E Aryan, Thomas J Errico, Vedat Deviren, Robert A Hart, Virginie Lafage, Frank Schwab, Michael D Daubs, Christopher P Ames
STUDY DESIGN: An electronic survey administered to Scoliosis Research Society (SRS) membership. OBJECTIVE: To characterize surgeon practices and views regarding the use of two attending surgeons for adult spinal deformity (ASD) surgery. SUMMARY OF BACKGROUND DATA: The use of two experienced attending surgeons can decrease the operative time, estimated blood loss, and perioperative complication rates. However, the current practice patterns for the use of two attending surgeons remains unknown...
June 15, 2017: Spine
https://www.readbyqxmd.com/read/28598335/complex-magnetic-order-from-multiple-ce-sites-in-ce-sub-3-sub-pd-sub-4-sub-sn-sub-6-sub
#13
Ernst-Wilhelm Scheidt, Andreas Fischer, Oliver Wybranski, Georg Eickerling, Wolfgang Scherer, Michael Baenitz, Franz Mayr, Birgit Heying, Rainer Poettgen
Polycrystalline Ce<sub>3</sub>Pd<sub>4</sub>Sn<sub>6</sub> samples were synthesized by arc-melting and subsequent annealing at 970K. Specific heat, electrical resistivity and magnetic susceptibility measurements are performed over a wide range in temperature and provide hints for the presence of a complex magnetic ordering below 3K arising from three crystallographically independent Ce sites. This behaviour is driven by a complex interplay between ferro-, ferri-, and antiferromagnetic correlations among the Ce atoms...
June 9, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28597797/percutaneous-intervention-for-central-shunts-new-routes-new-strategies
#14
Bjorn Cools, Stephen C Brown, Derize E Boshoff, Benedicte Eyskens, Ruth Heying, Filip Rega, Bart Meyns, Marc Gewillig
Introduction In traditional locations, the standard Blalock-Taussig shunt presents numerous technical difficulties for percutaneous intervention. We changed our strategy to a central type shunt (Laks-type) with end-to-side pulmonary and side-to-side aortic anastomosis. The aim of this study was to determine whether this modified strategy would allow easier percutaneous manipulation in patients with small pulmonary arteries. Methods All children with a stretchable central vascular graft who required any form of percutaneous intervention were prospectively enrolled in the study...
April 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28591017/reply-to-letter-hey-i-just-did-a-better-operation-toward-an-ideal-innovation-model
#15
James G Wright, Randi Zlotnik Shaul, Elise Héon, Jacob C Langer, Peggy W Law, Stephen P Sagar
No abstract text is available yet for this article.
July 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28591016/hey-i-just-did-a-better-operation-toward-an-ideal-innovation-model
#16
Akshay Sood, Mani Menon, Allison Hirst, Peter McCulloch, Khurshid R Ghani
No abstract text is available yet for this article.
July 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28580922/phosphate-binding-protein-from-polaromonas-js666-purification-characterization-crystallization-and-sulfur-sad-phasing
#17
Vanessa R Pegos, Louis Hey, Jacob LaMirande, Rachel Pfeffer, Rosalie Lipsh, Moshe Amitay, Daniel Gonzalez, Mikael Elias
Phosphate-binding proteins (PBPs) are key proteins that belong to the bacterial ABC-type phosphate transporters. PBPs are periplasmic (or membrane-anchored) proteins that capture phosphate anions from the environment and release them to the transmembrane transporter. Recent work has suggested that PBPs have evolved for high affinity as well as high selectivity. In particular, a short, unique hydrogen bond between the phosphate anion and an aspartate residue has been shown to be critical for selectivity, yet is not strictly conserved in PBPs...
June 1, 2017: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/28580384/genetic-risk-score-based-on-the-prevalence-of-vertebral-fracture-in-japanese-women-with-osteoporosis
#18
Heying Zhou, Seijiro Mori, Tatsuro Ishizaki, Atsushi Takahashi, Koichi Matsuda, Yukihiro Koretsune, Shiro Minami, Masahiko Higashiyama, Shinji Imai, Kozo Yoshimori, Minoru Doita, Akira Yamada, Satoshi Nagayama, Kazuo Kaneko, Satoshi Asai, Masaki Shiono, Michiaki Kubo, Hideki Ito
A genetic risk score (GRS) was developed for predicting fracture risk based on the prevalence of vertebral fractures in 441 Japanese females with osteoporosis. A total of 979 (858 nonsynonymous and 121 silent) single-nucleotide polymorphisms (SNPs) located in 74 osteoporosis-susceptibility genes were genotyped and evaluated for their association with fracture prevalence. Four SNPs (protein kinase domain containing, cytoplasmic [PKDCC; rs4952590], CDK5-regulatory subunit-associated protein 1-like 1 [CDKAL1; rs4712556], wingless-type MMTV-integration site family member 16 [WNT16; rs2707466], and G-patch domain-containing gene 1 [GPATCH1; rs10416265]) showed a significant association (p < 0...
December 2016: Bone Reports
https://www.readbyqxmd.com/read/28569505/copper-i-complexes-of-a-flexible-bis-phospholane-ligand-route-to-paddle-wheel-and-box-type-macrocycles
#19
Paul Boar, Markus Streitberger, Peter Lönnecke, Evamarie Hey-Hawkins
Two bis-phospholane copper(I) metallamacrocycles were selectively synthesized starting from the same two building blocks, namely, ligand 1 and [Cu(NCCH3)4]BF4. Reaction conditions (ligand:metal (L:M) ratio and dilution) can be tuned to obtain either a paddle-wheel- (2, L:M = 3:2) or box-type complex (3, L:M = 8:4). Their structures were unequivocally determined by X-ray crystallography. The solution (31)P{(1)H} NMR spectrum of complex 2 consists of a broad signal, as is common for such complexes, whereas complex 3 shows splitting of the (31)P{(1)H} NMR signal into a pseudoquartet due to (63,65)Cu-(31)P coupling, a rare occurrence exhibited only by highly symmetrical copper(I) phosphine complexes...
June 1, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28569429/carborev-5901-the-first-carborane-based-inhibitor-of-the-5-lipoxygenase-pathway
#20
Robert Kuhnert, Menyhárt-Botond Sárosi, Sven George, Peter Lönnecke, Bettina Hofmann, Dieter Steinhilber, Blagoje Murganic, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Evamarie Hey-Hawkins
The progression of cancer is accelerated by increased proliferation, angiogenesis, and inflammation. These processes are mediated by leukotrienes. Several cancer cell lines overexpress 5-lipoxygenase, an enzyme that converts arachidonic acid into leukotrienes. An early inhibitor of the 5-lipoxygenase pathway is Rev-5901, which, however, lacks in in vivo efficacy, as it is rapidly metabolized. We investigated the introduction of carboranes as highly hydrophobic and metabolically stable pharmacophores into lipoxygenase inhibitors...
June 1, 2017: ChemMedChem
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