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REVIEW
Simone Dalm, Heying Duan, Andrei Iagaru
Each tumor has its own distinctive molecular identity. Treatment, therefore, should be tailored to this unique cancer phenotype. Theragnostics uses the same compound for targeted imaging and treatment, radiolabeled to an appropriate radionuclide, respectively. Gastrin-releasing peptide receptors (GRPRs) are overexpressed in prostate cancer, and radiolabeled GRPR antagonists have shown high diagnostic performance at staging and biochemical recurrence. Several GRPR-targeting theragnostic compounds have been developed preclinically...
April 20, 2024: PET Clinics
#2
JOURNAL ARTICLE
Aleksandr Kazimir, Tom Götze, Peter Lönnecke, Blagoje Murganić, Sanja Mijatović, Danijela Maksimović-Ivanić, Evamarie Hey-Hawkins
Triple-negative breast cancer (TNBC) poses challenges in therapy due to the absence of target expression such as estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Frequently, the treatment of TNBC involves the combination of several therapeutics. However, an enhanced therapeutic effect can be also achieved within a single molecule. The efficacy of raloxifene can be improved by designing a raloxifene-based hybrid drug bearing a 2,2'-bipyridine moiety (2)...
April 20, 2024: ChemMedChem
#3
JOURNAL ARTICLE
Wenhao Zhong, Heye Zhang, Zhifan Gao, William Kongto Hau, Guang Yang, Xiujian Liu, Lin Xu
Vascular structure segmentation in intravascular ultrasound (IVUS) images plays an important role in pre-procedural evaluation of percutaneous coronary intervention (PCI). However, vascular structure segmentation in IVUS images has the challenge of structure-dependent distractions. Structure-dependent distractions are categorized into two cases, structural intrinsic distractions and inter-structural distractions. Traditional machine learning methods often rely solely on low-level features, overlooking high-level features...
April 12, 2024: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
#4
JOURNAL ARTICLE
Hong Song, Maria Isabel Leonio, Valentina Ferri, Heying Duan, Carina Mari Aparici, Guido Davidzon, Benjamin L Franc, Farshad Moradi, Jagruti Shah, Colin P Bergstrom, Alice C Fan, Sumit Shah, Ali Raza Khaki, Sandy Srinivas, Andrei Iagaru
PURPOSE: Lutetium-177 [177 Lu]Lu-PSMA-617 radioligand therapy (RLT) represents a significant advancement for metastatic castration-resistant prostate cancer (mCRPC), demonstrating improvements in radiographic progression free survival (rPFS) and overall survival (OS) with a low rate of associated side effects. Currently, most post-therapy SPECT/CT is conducted at 24 h after infusion. This study examines the clinical utility of a next-generation multi-detector Cadmium-Zinc-Telluride (CZT) SPECT/CT system (StarGuide) in same-day post-infusion assessment and early treatment response to [177 Lu]Lu-PSMA-617...
April 18, 2024: European Journal of Nuclear Medicine and Molecular Imaging
#5
JOURNAL ARTICLE
Zhenxin Fan, Rusong Zhang, Anbo Zhou, Jody Hey, Yang Song, Naoki Osada, Yuzuru Hamada, Bisong Yue, Jinchuan Xing, Jing Li
The genus Macaca is widely distributed, occupies a variety of habitats, shows diverse phenotypic characteristics, and is one of the best-studied genera of nonhuman primates. Here, we reported five re-sequencing Macaca genomes, including one M. cyclopis, one M. fuscata, one M. thibetana, one M. silenus, and one M. sylvanus. Together with published genomes of other macaque species, we combined 20 genome sequences of 10 macaque species to investigate the gene introgression and genetic differences among the species...
April 18, 2024: Journal of Molecular Evolution
#6
JOURNAL ARTICLE
Anastasiia Sherstiuk, Agustí Lledós, Peter Lönnecke, Jordi Hernando, Rosa María Sebastián, Evamarie Hey-Hawkins
Homogeneous transition metal catalysis is a constantly developing field in chemical sciences. A growing interest in this area is photoswitchable catalysis, which pursues in situ modulation of catalyst activity through noninvasive light irradiation. Phosphorus ligands are excellent targets to accomplish this goal by introducing photoswitchable moieties; however, only a limited number of examples have been reported so far. In this work, we have developed a series of palladium complexes capable of catalyzing the Stille coupling reaction that contain photoisomerizable phosphine ligands based on dithienylethene switches...
April 16, 2024: Inorganic Chemistry
#7
JOURNAL ARTICLE
Kaiyang Song, Molly Hey, Rebecca Elizabeth Payne
Background The COVID-19 pandemic necessitated the widespread rollout of teleconsultations across primary care services in the UK. The media's depiction of remote consultations, especially regarding their safety, is not well-established. These insights are important: newspapers' coverage of healthcare-related news can influence public perception, national policy and clinicians' job satisfaction. Aim To explore how the national newspapers in the UK depicted both the direct and indirect consequences of the remote-first approach on patient safety...
April 15, 2024: British Journal of General Practice
#8
JOURNAL ARTICLE
Zisiye Mu, Zhun Liang, Jing Yang, Shixiang Wei, Yang Zhao, Heying Zhou
Many studies have shown that multidrug and toxic compound extrusion (MATE) is a new secondary transporter family that plays a key role in secondary metabolite transport, the transport of plant hormones and disease resistance in plants. However, detailed information on this family in Gleditsia sinensis has not yet been reported. In the present study, a total of 45 GsMATE protein members were identified and analysed in detail, including with gene classification, phylogenetic evaluation and conserved motif determination...
April 2024: Functional Plant Biology: FPB
#9
JOURNAL ARTICLE
Shichang Lian, Zhifan Gao, Hui Wang, Xiujian Liu, Lei Xu, Huafeng Liu, Heye Zhang
Determining the location of myocardial infarction is crucial for clinical management and therapeutic stratagem. However, existing diagnostic tools either sacrifice ease of use or are limited by their spatial resolution. Addressing this, we aim to refine myocardial infarction localization via surface potential reconstruction of the ventricles in 12-lead electrocardiograms (ECG). A notable obstacle is the ill-posed nature of such reconstructions. To overcome this, we introduce the frequency-enhanced geometric-constrained iterative network (FGIN)...
April 10, 2024: IEEE Transactions on Bio-medical Engineering
#10
JOURNAL ARTICLE
V Koneti Rao, Elaine M Kulm, Jennifer K Grossman, David K Buchbinder, Hey Chong, Jason Bradt, Sharon Webster, Anna Šedivá, Virgil A Dalm, Gulbu Uzel
Activated phosphoinositide 3-kinase delta syndrome (APDS) is an inborn error of immunity that manifests as immune deficiency and dysregulation; symptoms include frequent infections and lymphoproliferation. In our dose-finding and phase 3 placebo-controlled trials, treatment with the selective PI3Kδ inhibitor leniolisib reduced lymphoproliferation and normalized lymphocyte subsets. Here, we present 6 years of follow-up from the 6 adult patients in the original dose-finding trial receiving leniolisib. We used data from the ongoing open-label extension study, which was supplemented at later time points by investigators, including health-related quality of life assessed through a clinician-reported questionnaire...
April 9, 2024: Blood Advances
#11
JOURNAL ARTICLE
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JOURNAL ARTICLE
Jennie Brown, Lauren Cox, Kathleen Mulligan, Stephanie Wilson, Michelle Heys, Polly Livermore, Suzy Gray, Angeliki Bogosian
BACKGROUND: Young people (YP) with long-term conditions (LTCs) are at greater risk of psychological distress than those without LTCs. Despite this, there is a scarcity of quality digital interventions designed to help improve mental wellbeing in this population. The aim of this study was to determine what YP, parents and health professionals preferred for future interventions. METHODS: Twenty-six YP with asthma, diabetes and/or epilepsy (the three most common LTCs in YP), 23 parents of YP with LTCs and 10 health professionals mainly in paediatric specialisms (total n = 59) took part in an online Delphi study to gain consensus (set at 75% agreement) on four questions across three rounds...
April 2024: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
#13
JOURNAL ARTICLE
John McDonnell, Kimberley Cousins, M Elizabeth M Younger, Adam Lane, Hassan Abolhassani, Roshini S Abraham, Salem Al-Tamemi, Juan Carlos Aldave-Becerra, Eman Hesham Al-Faris, Alberto Alfaro-Murillo, Suzan A AlKhater, Nouf Alsaati, Alexa Michelle Altman Doss, Melissa Anderson, Ernestina Angarola, Barbara Ariue, Danielle E Arnold, Amal H Assa'ad, Caner Aytekin, Meaghan Bank, Jenna R E Bergerson, Jack Bleesing, John Boesing, Carolina Bouso, Nicholas Brodszki, Diana Cabanillas, Carol Cady, Meghan A Callahan, Roberta Caorsi, Javier Carbone, Maria Carrabba, Riccardo Castagnoli, Jason R Catanzaro, Samantha Chan, Sharat Chandra, Hugo Chapdelaine, Zahra Chavoshzadeh, Hey Jin Chong, Lori Connors, Filippo Consonni, Oscar Correa-Jimenez, Charlotte Cunningham-Rundles, Katherine D'Astous-Gauthier, Ottavia Maria Delmonte, Yesim Yilmaz Demirdag, Deepti R Deshpande, Natalie M Diaz-Cabrera, Victoria R Dimitriades, Rasha El-Owaidy, Gehad ElGhazali, Suleiman Al-Hammadi, Giovanna Fabio, Astrid Schellnast Faure, Jin Feng, James M Fernandez, Lauren Fill, Guacira R Franco, Robert W Frenck, Ramsay L Fuleihan, Giuliana Giardino, Jessica Galant-Swafford, Eleonora Gambineri, Elizabeth K Garabedian, Ashley V Geerlinks, Ekaterini Goudouris, Octavio Grecco, Qiang Pan-Hammarström, Hedieh Haji Khodaverdi Khani, Lennart Hammarström, Nicholas L Hartog, Jennifer Heimall, Gabriela Hernandez-Molina, Caroline C Horner, Robert W Hostoffer, Nataliya Hristova, Kuang-Chih Hsiao, Gabriela Ivankovich-Escoto, Faris Jaber, Maaz Jalil, Mahnaz Jamee, Tiffany Jean, Stephanie Jeong, Devi Jhaveri, Michael B Jordan, Avni Y Joshi, Amanpreet Kalkat, Henry J Kanarek, Erinn S Kellner, Amer Khojah, Ruby Khoury, Cristina M Kokron, Ashish Kumar, Kelsey Lecerf, Heather K Lehman, Jennifer W Leiding, Harry Lesmana, Xin Rong Lim, Joao Pedro Lopes, Ana Laura López, Lucia Tarquini, Ingrid S Lundgren, Julieann Magnusson, Ana Karolina B B Marinho, Gian Luigi Marseglia, Giulia M Martone, Annamaria G Mechtler, Leonardo Mendonca, Joshua D Milner, Peter J Mustillo, Asal Gharib Naderi, Samuele Naviglio, Jeremy Nell, Hana B Niebur, Luigi Notarangelo, Matias Oleastro, María Claudia Ortega-López, Neil R Patel, Gordana Petrovic, Claudio Pignata, Oscar Porras, Benjamin T Prince, Jennifer M Puck, Nashmia Qamar, Marco Rabusin, Nikita Raje, Lorena Regairaz, Kimberly A Risma, Elizabeth H Ristagno, John Routes, Persio Roxo-Junior, Negin Salemi, Christopher Scalchunes, Susan J Schuval, Suranjith L Seneviratne, Ashwin Shankar, Roya Sherkat, Junghee Jenny Shin, Abeer Siddiqi, Sara Signa, Ali Sobh, Fabiana Mascarenhas Souza Lima, Kristen K Stenehjem, Jonathan S Tam, Monica Tang, Myrthes Toledo Barros, James Verbsky, Eleni Vergadi, Dayne H Voelker, Stefano Volpi, Luke A Wall, Christine Wang, Kelli W Williams, Eveline Y Wu, Shan Shan Wu, Jessie J Zhou, Alexandria Cook, Kathleen E Sullivan, Rebecca Marsh
BACKGROUND: The CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, and whether vaccination attenuates infection severity in IEI. OBJECTIVE: To estimate COVID-19 vaccination safety and examine effect on outcomes in patients with IEI. METHODS: We built a secure registry database in conjunction with the US Immunodeficiency Network to examine vaccination frequency and indicators of safety and effectiveness in IEI patients...
April 5, 2024: Journal of Clinical Immunology
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JOURNAL ARTICLE
Richard Holland, Kieu Lam, Sunny Jeng, Kevin McClintock, Lorne Palmer, Petra Schreiner, Mark Wood, Wenchen Zhao, James Heyes
The advent of mRNA for nucleic acid (NA) therapeutics has unlocked many diverse areas of research and clinical investigation. However, the shorter intracellular half-life of mRNA compared with other NAs may necessitate more frequent dosing regimens. Because lipid nanoparticles (LNPs) are the principal delivery system used for mRNA, this could lead to tolerability challenges associated with an accumulated lipid burden. This can be addressed by introducing enzymatically cleaved carboxylic esters into the hydrophobic domains of lipid components, notably, the ionizable lipid...
April 3, 2024: ACS Nano
#15
JOURNAL ARTICLE
Shaowei Zhang, Laura N Jeffreys, Harshwardhan Poddar, Yuqi Yu, Chuanyang Liu, Kaylee Patel, Linus O Johannissen, Lingyun Zhu, Matthew J Cliff, Cunyu Yan, Giorgio Schirò, Martin Weik, Michiyo Sakuma, Colin W Levy, David Leys, Derren J Heyes, Nigel S Scrutton
Photoreceptor proteins utilise chromophores to sense light and trigger a biological response. The discovery that adenosylcobalamin (or coenzyme B12 ) can act as a light-sensing chromophore heralded a new field of B12 -photobiology. Although microbial genome analysis indicates that photoactive B12 -binding domains form part of more complex protein architectures, regulating a range of molecular-cellular functions in response to light, experimental evidence is lacking. Here we identify and characterise a sub-family of multi-centre photoreceptors, termed photocobilins, that use B12 and biliverdin (BV) to sense light across the visible spectrum...
March 28, 2024: Nature Communications
#16
JOURNAL ARTICLE
Matthew J Landry, Mateja R Savoie-Roskos, Virginia Gray, Georgianna Mann, Zubaida Qamar, Rebecca L Hagedorn-Hatfield, Cara L Cuite, Emily Heying, Lanae B Hood, Kendra OoNorasak
Food insecurity among college students has become a growing concern, with reports documenting its prevalence for over a decade. As the demographics of university and college students change, with more first-generation, nontraditional, and minority students, the risk of food insecurity is heightened. This viewpoint contends that food security is an essential basic need among college students, and when left unmet, it significantly impacts their well-being, resulting in an increased risk of poor academic performance or departure from higher education before degree completion...
March 28, 2024: Journal of American College Health: J of ACH
#17
JOURNAL ARTICLE
Wen-Hai Zhuo, Hwee Weng Dennis Hey, Wing Moon Raymond Lam, Xiaoyun Chloe Chan, Loo Hoey Lit, Yong Soon Chiong, Hee-Kit Wong
The study aimed to examine matrix metalloproteinase-2 (MMP-2) expression in a rat ligamentum flavum (LF) hypertrophy model in vivo, and the effect of elastin-derived peptides (EDPs) on MMP-2 and tissue inhibitors of metalloproteinases (TIMPs) in rat LF cells in vitro. Surgical destabilization was performed at the rat spinal L3/4 level to induce increased mechanical stress. Rats were killed at 6- and 12-weeks postsurgery for histological staining, immunohistochemical staining, RT-qPCR and western blot. 100 µg/mL EDPs were applied to isolated normal rat LF cells, with or without pretreatment of elastin receptor complex (ERC) inhibitors, to assess the expression of MMP-2, TIMP-1, and TIMP-2...
March 28, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
#18
JOURNAL ARTICLE
Hui Liu, Xing Ji, Haichang Sun, Craig Billington, Xiang Hou, Abbas Soleimani-Delfan, Ran Wang, Heye Wang, Lili Zhang
Cronobacter spp. are the most concerning foodborne pathogen in infant formula milk powder. Currently, there are many reports on the prevalence of Cronobacter spp. in infant formula milk and its processing environment, but there are few studies on the prevalence of Cronobacter spp. on dairy farms. We have, therefore, undertaken this study to investigate and track genomic epidemiology of Cronobacter spp. isolates from Chinese dairy farms in the provinces of Jiangsu and Shandong. In this study, forty Cronobacter spp...
March 13, 2024: Foods (Basel, Switzerland)
#19
JOURNAL ARTICLE
Linyuan Yu, Chenyu Ling, Yizhu Li, Huiduo Guo, Anying Xu, Heying Qian, Gang Li
G protein β subunit 1 (GNβ1) has several functions, including cell growth regulation, the control of second messenger levels, and ion channel switching. Previous transcriptome analyses in our laboratory have shown that BmGNβ1 transcription is reduced following infection with Bombyx mori nucleopolyhedrovirus (BmNPV), but it is unknown what role this gene may have in the host response to BmNPV infection. In this study, the BmGNβ1 gene was cloned using the RACE method. After BmNPV infection, BmGNβ1 was downregulated in Baiyu strains in tissues such as the hemolymph and midgut...
March 25, 2024: Journal of Invertebrate Pathology
#20
JOURNAL ARTICLE
Svenja Buth, Izet Baljić, Alexander Mewes, Matthias Hey
BACKGROUND: Binaural hearing enables better speech comprehension in noisy environments and is necessary for acoustic spatial orientation. This study investigates speech discrimination in noise with separated signal sources and measures sound localization. The aim was to study characteristics and reproducibility of two selected measurement techniques which seem to be suitable for description of the aforementioned aspects of binaural hearing. MATERIALS AND METHODS: Speech reception thresholds (SRT) in noise and test-retest reliability were collected from 55 normal-hearing adults for a spatial setup of loudspeakers with angles of ± 45° and ± 90° using the Oldenburg sentence test...
March 27, 2024: HNO
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