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https://www.readbyqxmd.com/read/28930682/chemically-induced-degradation-of-the-oncogenic-transcription-factor-bcl6
#1
Nina Kerres, Steffen Steurer, Stefanie Schlager, Gerd Bader, Helmut Berger, Maureen Caligiuri, Christian Dank, John R Engen, Peter Ettmayer, Bernhard Fischerauer, Gerlinde Flotzinger, Daniel Gerlach, Thomas Gerstberger, Teresa Gmaschitz, Peter Greb, Bingsong Han, Elizabeth Heyes, Roxana E Iacob, Dirk Kessler, Heike Kölle, Lyne Lamarre, David R Lancia, Simon Lucas, Moriz Mayer, Katharina Mayr, Nikolai Mischerikow, Katja Mück, Christoph Peinsipp, Oliver Petermann, Ulrich Reiser, Dorothea Rudolph, Klaus Rumpel, Carina Salomon, Dirk Scharn, Renate Schnitzer, Andreas Schrenk, Norbert Schweifer, Diane Thompson, Elisabeth Traxler, Roland Varecka, Tilman Voss, Alexander Weiss-Puxbaum, Sandra Winkler, Xiaozhang Zheng, Andreas Zoephel, Norbert Kraut, Darryl McConnell, Mark Pearson, Manfred Koegl
The transcription factor BCL6 is a known driver of oncogenesis in lymphoid malignancies, including diffuse large B cell lymphoma (DLBCL). Disruption of its interaction with transcriptional repressors interferes with the oncogenic effects of BCL6. We used a structure-based drug design to develop highly potent compounds that block this interaction. A subset of these inhibitors also causes rapid ubiquitylation and degradation of BCL6 in cells. These compounds display significantly stronger induction of expression of BCL6-repressed genes and anti-proliferative effects than compounds that merely inhibit co-repressor interactions...
September 19, 2017: Cell Reports
https://www.readbyqxmd.com/read/28929066/surgical-treatment-of-retrosternal-goitre
#2
Kiera Welman, Richard Heyes, Paras Dalal, Sarah Hough, Marciano Bunalade, Vladimir Anikin
This study aims to evaluate surgical approaches to the management of retrosternal goitre. Between 2004 and 2014, 35 patients (eight males; mean age 67.4 ± 10.9 years) with retrosternal goitre (mainly right-sided in 9, left-sided in 14 and bilateral in 12) underwent surgery. A palpable neck mass was found in 11 (31.4%), stridor in 10 (28.6%) and thyrotoxicosis in 4 (11.4%) cases. 4 (11.4%) patients were asymptomatic. Tracheal compression was detected radiologically in 27 (77.2%) patients with deviation in 18 (51...
September 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28919941/a-test-of-the-submentalizing-hypothesis-apes-performance-in-a-false-belief-task-inanimate-control
#3
Christopher Krupenye, Fumihiro Kano, Satoshi Hirata, Josep Call, Michael Tomasello
Much debate concerns whether any nonhuman animals share with humans the ability to infer others' mental states, such as desires and beliefs. In a recent eye-tracking false-belief task, we showed that great apes correctly anticipated that a human actor would search for a goal object where he had last seen it, even though the apes themselves knew that it was no longer there. In response, Heyes proposed that apes' looking behavior was guided not by social cognitive mechanisms but rather domain-general cueing effects, and suggested the use of inanimate controls to test this alternative submentalizing hypothesis...
2017: Communicative & Integrative Biology
https://www.readbyqxmd.com/read/28912037/the-role-of-mental-imagery-in-mood-amplification-an-investigation-across-subclinical-features-of-bipolar-disorders
#4
Caitlin O'Donnell, Martina Di Simplicio, Randi Brown, Emily A Holmes, Stephanie Burnett Heyes
Vivid emotional mental imagery has been identified across a range of mental disorders. In bipolar spectrum disorders - psychopathologies characterized by mood swings that alternate between depression and mania, and include irritability and mixed affect states - mental imagery has been proposed to drive instability in both 'positive' and 'negative' mood. That is, mental imagery can act as an "emotional amplifier". The current experimental study tested this hypothesis and investigated imagery characteristics associated with mood amplification using a spectrum approach to psychopathology...
August 18, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28887534/phylogeographic-studies-of-schizothoracine-fishes-on-the-central-qinghai-tibet-plateau-reveal-the-highest-known-glacial-microrefugia
#5
Yangyang Liang, Dekui He, Yintao Jia, Heying Sun, Yifeng Chen
Pleistocene climatic oscillations have greatly influenced the evolutionary history and distribution pattern of most extant species. However, their effects on species on the Qinghai-Tibet Plateau (QTP) are not well understood. To investigate the effects of past climatic shifts, particularly the Last Glacial Maximum (LGM), on plateau fish, we analysed the phylogeographic structure and demographic history of five closely related taxa of the subfamily Schizothoracinae, a representative endemic taxon of the QTP, from nine endorheic lakes on the central QTP and three peripheral exorheic rivers using the mitochondrial control region (D-loop) sequence and 12 microsatellite (SSR) markers...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28878295/garcinone-e-induces-apoptosis-and-inhibits-migration-and-invasion-in-ovarian-cancer-cells
#6
Xiao-Huang Xu, Qian-Yu Liu, Ting Li, Jian-Lin Liu, Xin Chen, Li Huang, Wen-An Qiang, Xiuping Chen, Yitao Wang, Li-Gen Lin, Jin-Jian Lu
Ovarian cancer remains the most lethal gynecological malignant tumor. In this study, 24 xanthones were isolated and identified from the pericarps of mangosteen (Garcinia mangostana), and their anti-proliferative activities were tested in ovarian cancer cells. Garcinone E (GE) was found to exhibit excellent anti-proliferative effects among the tested xanthones. It significantly inhibited the proliferation in HEY, A2780, and A2780/Taxol cells as evidenced by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, lactate dehydrogenase (LDH) release assay, Hoechst 33342 staining, annexin V/PI staining, and JC-1 staining...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28877118/message-from-the-editor
#7
Chung-Hey Chen
No abstract text is available yet for this article.
October 2017: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/28866487/motion-tracking-of-the-carotid-artery-wall-from-ultrasound-image-sequences-a-nonlinear-state-space-approach
#8
Zhifan Gao, Yanjie Li, Yuanyuan Sun, Jiayuan Yang, Huahua Xiong, Heye Zhang, Xin Liu, Wanqing Wu, Dong Liang, Shuo Li
The motion of the common carotid artery (CCA) wall has been established to be useful in early diagnosis of atherosclerotic disease. However, tracking the CCA wall motion from ultrasound images remains a challenging task. In this study, a nonlinear state-space approach has been developed to track CCA wall motion from ultrasound sequences. In this approach, a nonlinear state-space equation with a time-variant control signal was constructed from a mathematical model of the dynamics of the CCA wall. Then, the unscented Kalman filter (UKF) was adopted to solve the nonlinear state transfer function in order to evolve the state of the target tissue, which involves estimation of the motion trajectory of the CCA wall from noisy ultrasound images...
August 30, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28860375/influence-integrity-and-the-fda-an-ethical-framework
#9
Spencer Phillips Hey, I Glenn Cohen, Eli Y Adashi, Aaron S Kesselheim
No abstract text is available yet for this article.
September 1, 2017: Science
https://www.readbyqxmd.com/read/28856557/endothelial-cells-promote-formation-of-medulloblastoma-stem-like-cells-via-notch-pathway-activation
#10
Yong Wang, Yushe Wang, Hang Chen, Qinghua Liang
The aim of the study is to investigate whether endothelial cells (ECs) promoted the capacity of stem-like cell formation in medulloblastoma (MB) and whether the mechanism of action was associated with mediation of Notch signaling pathway. Co-culture experiment was conducted to particularly understand the potential role of ECs in promoting phenotype and gene expression of MB stem-like cells. Self-renewal capacity and tumor cell population were measured by sphere-forming assay and flow cytometry, respectively...
August 30, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28853196/a-new-screening-strategy-for-varices-by-liver-and-spleen-stiffness-measurement-lssm-in-cirrhotic-patients-a-randomized-trial
#11
Grace Lai-Hung Wong, Raymond Kwok, Aric Josun Hui, Yee-Kit Tse, Kai-Tin Ho, Angeline Oi-Shan Lo, Kelvin Long-Yan Lam, Heyson Chi-Hey Chan, Rashid Abdul Lui, Kenneth Hon-Da Au, Henry Lik-Yuen Chan, Vincent Wai-Sun Wong
BACKGROUND: Variceal bleeding is a common and life-threatening complication in patients with liver cirrhosis. Screening with upper endoscopy is recommended but is uncomfortable to patients. Non-invasive assessment with transient elastography for liver/spleen stiffness measurement (LSM and SSM) is accurate in detecting varices. AIMS: To test the hypothesis that a new screening strategy for varices guided by LSM/SSM results (LSSM-guided) is non-inferior to universal endoscopic screening in detecting clinically significant varices in patients with cirrhosis...
August 29, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28827561/influence-of-beat-to-beat-blood-pressure-variability-on-vascular-elasticity-in-hypertensive-population
#12
Yufa Xia, Xin Liu, Dan Wu, Huahua Xiong, Lijie Ren, Lin Xu, Wanqing Wu, Heye Zhang
Whether elevated beat-to-beat blood pressure variability (BPV) has an influence on vascular elasticity is confounded and poorly understood. This study hypothesized that the increased BPV could have an adverse effect on the vascular elasticity, as estimated by total arterial compliance (TAC), independent of blood pressure (BP) values. Beat-to-beat BP and TAC were measured in 81 hypertensive patients (experimental population) and in 80 normal adults (control population). Beat-to-beat BPV was assessed by standard deviation (SD), average real variability (ARV), residual standard deviation (RSD) and variation independent of mean (VIM)...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28822824/using-spinopelvic-parameters-to-estimate-residual-lumbar-lordosis-assuming-previous-lumbosacral-fusion-a-study-of-normative-values
#13
Hwee Weng Dennis Hey, Kimberly-Anne Tan, Shashidhar Bangalore Kantharajanna, Alex Quok An Teo, Chloe Xiaoyun Chan, Ka-Po Gabriel Liu, Hee-Kit Wong
BACKGROUND CONTEXT: Pelvic Incidence (PI) = Pelvic Tilt (PT) + Sacral Slope (SS) is an established trigonometric equation which can be expanded from studying the fixed pelvis with the spine to a fixed spinopelvic complex with the remnant spine, in scenarios of spinopelvic fusion or ankylosis. For a fixed spinopelvic complex, we propose the equation termed: Lumbar Incidence (LI) = Lumbar Tilt (LT) + Lumbar Slope (LS). PURPOSE: To establish reference values for LI, LT and LS at each lumbar vertebral level, and to show how LI can be used to determine rLL...
August 16, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28821807/sulfate-reduction-in-sediments-produces-high-levels-of-chromophoric-dissolved-organic-matter
#14
Jenna L Luek, Kaitlyn E Thompson, Randolph K Larsen, Andrew Heyes, Michael Gonsior
Sulfate reduction plays an important role in altering dissolved organic matter (DOM) in estuarine and coastal sediments, although its role in the production of optically active chromophoric DOM (CDOM) and a subset of fluorescent DOM (FDOM) has not been previously investigated in detail. Freshwater sediment slurries were incubated anaerobically with added sulfate and acetate to promote sulfate-reducing bacteria. Ultraviolet visible (UV-Vis) absorbance and 3-dimensional excitation emission matrix (EEM) fluorescence spectra were measured over a five weeks anaerobic dark incubation period...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28809790/genome-wide-organization-and-expression-profiling-of-the-sbp-box-gene-family-in-chinese-jujube-ziziphus-jujuba-mill
#15
Shuang Song, Heying Zhou, Songbai Sheng, Ming Cao, Yingyue Li, Xiaoming Pang
Transcription factors play vital roles in the developmental processes of plants. The SQUAMOSA promoter binding protein (SBP) genes encode a family of plant-specific transcription factors and plays many crucial roles in plant development. In this study, 16 SBP-box gene family members were identified in Ziziphus jujuba Mill. Dongzao (Dongzao), which were distributed over 8 chromosomes. They were classified into seven groups according to their phylogenetic relationships with other SBP-box gene families. Within each group, genes shared similar exon-intron structures and motif locations...
August 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28805715/identification-and-analysis-of-mitogen-activated-protein-kinase-mapk-cascades-in-fragaria-vesca
#16
Heying Zhou, Suyue Ren, Yuanfang Han, Qing Zhang, Ling Qin, Yu Xing
Mitogen-activated protein kinase (MAPK) cascades are highly conserved signaling modules in eukaryotes, including yeasts, plants and animals. MAPK cascades are responsible for protein phosphorylation during signal transduction events, and typically consist of three protein kinases: MAPK, MAPK kinase, and MAPK kinase kinase. In this current study, we identified a total of 12 FvMAPK, 7 FvMAPKK, 73 FvMAPKKK, and one FvMAPKKKK genes in the recently published Fragaria vesca genome sequence. This work reported the classification, annotation and phylogenetic evaluation of these genes and an assessment of conserved motifs and the expression profiling of members of the gene family were also analyzed here...
August 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28799598/antiproliferative-activity-of-%C3%AE-6-arene-ruthenacarborane-sandwich-complexes-against-hct116-and-mcf7-cell-lines
#17
Marta Gozzi, Benedikt Schwarze, Menyhárt-Botond Sárosi, Peter Lönnecke, Dijana Drača, Danijela Maksimović-Ivanić, Sanja Mijatović, Evamarie Hey-Hawkins
Three [(η(6)-arene)RuC2B9H11] complexes (arene = p-cymene (2), biphenyl (3) and 1-Me-4-COOEt-C6H4 (4)) were synthesised according to modified literature procedures and fully characterised. 2-4 were found to be moderately active against two types of tumour cell lines (HCT116 and MCF7), with IC50 values in the low micromolar range. However, viability of normal, healthy cells (MRC-5 cell line, MLEC and mouse macrophages) was not affected by treatment with 2-4, indicating high selectivity of the metallacarborane complexes towards tumour cell lines, compared to the unselective antitumour agent cisplatin and other potential Ru(II) drugs...
September 28, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28799381/chemical-potential-of-a-test-hard-sphere-of-variable-size-in-a-hard-sphere-fluid
#18
David M Heyes, Andrés Santos
The Labík and Smith Monte Carlo simulation technique to implement the Widom particle insertion method is applied using Molecular Dynamics (MD) instead to calculate numerically the insertion probability, P0(η,σ0), of tracer hard-sphere (HS) particles of different diameters, σ0, in a host HS fluid of diameter σ and packing fraction, η, up to 0.5. It is shown analytically that the only polynomial representation of -ln⁡P0(η,σ0) consistent with the limits σ0→0 and σ0→∞ has necessarily a cubic form, c0(η)+c1(η)σ0/σ+c2(η)(σ0/σ)(2)+c3(η)(σ0/σ)(3)...
December 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28794252/white-matter-hyperintensity-reduction-and-outcomes-after-minor-stroke
#19
Joanna M Wardlaw, Francesca M Chappell, Maria Del Carmen Valdés Hernández, Stephen D J Makin, Julie Staals, Kirsten Shuler, Michael J Thrippleton, Paul A Armitage, Susana Muñoz-Maniega, Anna K Heye, Eleni Sakka, Martin S Dennis
OBJECTIVE: To assess factors associated with white matter hyperintensity (WMH) change in a large cohort after observing obvious WMH shrinkage 1 year after minor stroke in several participants in a longitudinal study. METHODS: We recruited participants with minor ischemic stroke and performed clinical assessments and brain MRI. At 1 year, we assessed recurrent cerebrovascular events and dependency and repeated the MRI. We assessed change in WMH volume from baseline to 1 year (normalized to percent intracranial volume [ICV]) and associations with baseline variables, clinical outcomes, and imaging parameters using multivariable analysis of covariance, model of changes, and multinomial logistic regression...
September 5, 2017: Neurology
https://www.readbyqxmd.com/read/28793256/dynamics-of-rna-polymerase-ii-pausing-and-bivalent-histone-h3-methylation-during-neuronal-differentiation-in-brain-development
#20
Jiancheng Liu, Xiwei Wu, Heying Zhang, Gerd P Pfeifer, Qiang Lu
During cellular differentiation, genes important for differentiation are expected to be silent in stem/progenitor cells yet can be readily activated. RNA polymerase II (Pol II) pausing and bivalent chromatin marks are two paradigms suited for establishing such a poised state of gene expression; however, their specific contributions in development are not well understood. Here we characterized Pol II pausing and H3K4me3/H3K27me3 marks in neural progenitor cells (NPCs) and their daughter neurons purified from the developing mouse cortex...
August 8, 2017: Cell Reports
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