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https://www.readbyqxmd.com/read/28304089/phosphorylated-fadd-is-not-prognostic-for-local-control-in-t1-t2-supraglottic-laryngeal-carcinoma-treated-with-radiotherapy
#1
Jan E Wachters, Michiel L Schrijvers, Lorian Slagter-Menkema, Mirjam Mastik, Johannes A Langendijk, Geertruida H de Bock, Jan L Roodenburg, Bernard F A M van der Laan, Jacqueline E van der Wal, Ed Schuuring
OBJECTIVE: The Fas-Associated Death Domain (FADD) gene is located in the chromosome 11q13-region and frequently is amplified in head and neck squamous cell carcinoma. Expression of FADD and its phosphorylated isoform (pFADD) have been associated with aggressive tumor growth, lymph node metastasis, and overall survival. Previously, we demonstrated that pFADD expression was related to a significantly improved local control in early stage (tumor [T]1 to T2) glottic laryngeal squamous cell carcinoma (LSCC)...
March 17, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28302228/anaesthetic-management-in-a-child-with-goldenhar-syndrome
#2
Waqas Ahmed Khan, Bushra Salim, Ausaf Ahmed Khan, Shakaib Chughtai
Goldenhar syndrome is a congenital disorder involving deformities of the face. It usually affects one side of the face only and poses significant challenges in the airway management. We herein, report an 8-year boy, known case of Goldenhar syndrome, who presented to our radiology suite for a magnetic resonance imaging (MRI) brain, followed by a computed tomography (CT) scan brain. The boy had various features of Goldenhar syndrome, e.g. cleft palate, absent right eye and ear, right mandibular hypoplasia, micrognathia, and preauricular tags...
March 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28301268/efficacy-and-toxicity-profiles-of-two-chemoradiotherapies-for-stage-ii-laryngeal-cancer-a-comparison-between-late-course-accelerated-hyperfractionation-lcahf-and-conventional-fractionation-cf
#3
Eiichiro Okazaki, Naoki Matsushita, Mari Tashiro, Yasuhiko Shimatani, Kentaro Ishii, Masako Hosono, Masahiro Oishi, Yuichi Teranishi, Hiroyoshi Iguchi, Yukio Miki
OBJECTIVE: To evaluate the treatment results of late course accelerated hyperfractionation (LCAHF) compared with conventional fractionation (CF) for stage II laryngeal cancer. METHODS: Fifty-nine consecutive patients treated for stage II laryngeal cancer were retrospectively reviewed. Thirty-two patients underwent LCAHF, twice-daily fractions during the latter half with a total dose of 69 Gy. Twenty-seven patients received CF of 70 Gy. RESULTS: The local control rates (LCRs), overall survival (OS), and disease-specific survival (DSS) at 5 years were 80...
March 16, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28301093/demonstration-of-transoral-robotic-supraglottic-laryngectomy-and-total-laryngectomy-in-cadaveric-specimens-using-the-medrobotics-flex-system
#4
Emily Funk, David Goldenberg, Neerav Goyal
BACKGROUND: Current management of laryngeal malignancies is associated with significant morbidity. Application of minimally invasive transoral techniques may reduce the morbidity associated with traditional procedures. The purpose of this study was to present our investigation of the utility of a novel flexible robotic system for transoral supraglottic laryngectomy and total laryngectomy. METHODS: Transoral total laryngectomy and transoral supraglottic laryngectomy were performed in cadaveric specimens using the Flex Robotic System (Medrobotics, Raynham, MA)...
March 16, 2017: Head & Neck
https://www.readbyqxmd.com/read/28298751/comparative-study-of-two-laryngeal-mask-airways-proseal-laryngeal-mask-airway-and-supreme-laryngeal-mask-airway-in-anesthetized-paralyzed-adults-undergoing-elective-surgery
#5
Ravneet Kaur Gill, Abhijit Tarat, Debagopal Pathak, Suneeta Dutta
CONTEXT: Supraglottic airway devices can act as an alternative to endotracheal intubation in both normal and difficult airway. LMA Proseal (P-LMA) and LMA Supreme (S-LMA) alongwith acting as effective ventilating device, provide port for gastric drainage. AIM: The objective of this study was to compare the two devices for effective ventilation and complications. SETTING AND DESIGN: A prospective, randomized, single-blinded study was conducted in a tertiary care teaching hospital...
January 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28294085/serum-cytokine-profile-of-laryngeal-squamous-cell-carcinoma-patients
#6
J Sotirović, A Perić, D Vojvodić, N Baletić, I Zaletel, I Stanojević, M Erdoglija, M Milojević
OBJECTIVES: This study aimed to evaluate serum cytokine concentrations in healthy individuals and laryngeal squamous cell carcinoma patients. METHODS: A total of 59 laryngeal squamous cell carcinoma patients and 44 healthy controls were included. Multiplex analysis of interleukins 2, 4, 5, 6, 10, 12, 13 and 17 and interferon-gamma with respect to the presence of laryngeal carcinoma, tumour-node-metastasis T stage, nodal involvement and larynx subsite was performed...
March 15, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28290958/comparative-assessment-of-three-approaches-of-teaching-nonmedically-trained-persons-in-the-handling-of-supraglottic-airways-a-randomized-controlled-trial
#7
Mario Hensel, Willi Schmidbauer, Michael Benker, Paula Schmieder, Thoralf Kerner
BACKGROUND: The use of supraglottic airways has been recommended in combat trauma airway management. To ensure an adequate airway management on the battlefield, suitable training concepts are sought to efficiently teach as many soldiers as possible. Our aim was to compare three approaches of teaching laypersons in the handling of supraglottic airways in a mannequin model. METHODS: In this prospective randomized blinded study, 285 military service men without any medical background were divided into three groups and trained in the use of the Laryngeal Mask Airway Supreme (LMA) and the Laryngeal Tube Disposable (LT-D)...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28279203/primary-burkitt-lymphoma-of-the-supraglottic-larynx-a-case-report-and-review-of-the-literature
#8
Alexandra E Quimby, Lisa Caulley, Danielle Rodin, Bibianna Purgina, Libni Eapen, Luke Shier, Stephanie Johnson-Obaseki
BACKGROUND: Burkitt lymphoma is a high-grade B cell lymphoma which accounts for less than 1% of all adult cases of non-Hodgkin lymphoma. Rare instances of Burkitt lymphoma developing secondary to prior irradiation have been described in the literature. CASE PRESENTATION: We report a case of a 90-year-old white woman with a recent history of irradiation for Hodgkin lymphoma, who presented with primary Burkitt lymphoma of the supraglottic larynx. She underwent emergency awake tracheostomy with biopsy...
March 10, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28267947/ambu%C3%A2-auragain%C3%A2-versus-lma-supreme%C3%A2-second-seal%C3%A2-a-randomised-controlled-trial-comparing-oropharyngeal-leak-pressures-and-gastric-drain-functionality-in-spontaneously-breathing-patients
#9
I I Shariffuddin, W H Teoh, Ebk Tang, Nhm Hashim, P S Loh
Newer second generation supraglottic airway devices may perform differently in vivo due to material and design modifications. We compared performance characteristics of the Ambu® AuraGain™ and LMA Supreme™ Second Seal™ in 100 spontaneously breathing anaesthetised patients in this randomised controlled study. We studied oropharyngeal leak pressures (OLP) (primary outcome) and secondarily, ease of insertion, success rates, haemodynamic response, time to insertion, and complications of usage. We found no significant difference in OLP between the AuraGain versus the LMA Supreme, mean (standard deviation, SD) 24...
March 2017: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/28251605/the-novel-video-assisted-intubating-laryngeal-mask-totaltrack-compared-to-the-intubating-laryngeal-mask-fastrach-a-controlled-randomized-manikin-study
#10
RANDOMIZED CONTROLLED TRIAL
T Ott, A Barth, M Kriege, A Jahn-Eimermacher, T Piepho, R R Noppens
BACKGROUND: The novel Totaltrack combines a supraglottic airway device with video laryngoscopic tracheal intubation. The intubation laryngeal mask Fastrach is an established device without visual control of intubation. We hypothesized that supraglottic ventilation success with Totaltrack would be similar to Fastrach, but intubation would be performed faster due to visual control of the procedure. METHODS: Fifty-five anaesthesiologists were randomized into one of two study arms: Fastrach Totaltrack...
April 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28243697/classification-system-for-lateral-pharyngotomy-systematic-study-of-anatomic-exposure-in-a-human-cadaver-model
#11
Courtney Shires, Aaron Smith, Jenn Lee, John Boughter, Merry Sebelik
INTRODUCTION: Lateral pharyngotomy (LP) is a surgical procedure that allows exposure to tumors of the pharynx and supraglottic larynx. This study was undertaken to: (1) propose a classification system of LP used in exposing various sites of the oropharynx, supraglottis, and hypopharynx. (2) Describe the structures visible with each category of LP. MATERIALS AND METHODS: Five tissue-fixed human cadavers from our gross anatomy laboratory were dissected in a manner similar to surgical lateral pharyngotomy...
February 27, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28236864/a-comparison-of-various-supraglottic-airway-devices-for-fiberoptical-guided-tracheal-intubation
#12
Thomas Metterlein, Anna Dintenfelder, Christoph Plank, Bernhard Graf, Gabriel Roth
BACKGROUND: Fiberoptical assisted intubation via placed supraglottic airway devices has been described as safe and easy procedure to manage difficult airways. However visualization of the glottis aperture is essential for fiberoptical assisted intubation. Various different supraglottic airway devices are commercially available and might offer different conditions for fiberoptical assisted intubation. The aim of this study was to compare the best obtainable view of the glottic aperture using different supraglottic airway devices...
March 2017: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/28225552/potential-clinical-significance-of-perioperative-levels-of-mrna-in-plasma-from-patients-with-cancer-of-the-larynx-or-hypopharynx
#13
Dolores C García-Olmo, J Diego Contreras, María G Picazo, Jesús López-Torres, Damián García-Olmo
BACKGROUND: The use of plasma as a "liquid biopsy" has gained increasing attention. The purpose of the present study was to evaluate the diagnostic and prognostic utility of the perioperative detection and quantitation of mRNAs encoding human telomerase reverse transcriptase (hTERT) and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in plasma from patients with cancer of the larynx or hypopharynx. METHODS: We recruited 47 patients with laryngeal cancer and 2 patients with hypopharyngeal cancer, plus 27 healthy subjects...
April 2017: Head & Neck
https://www.readbyqxmd.com/read/28224634/pepsin-as-a-biomarker-for-laryngopharyngeal-reflux-in-children-with-laryngomalacia
#14
Kendra Luebke, Tina L Samuels, Thomas H Chelius, Cecille G Sulman, Michael E McCormick, Joseph E Kerschner, Nikki Johnston, Robert H Chun
OBJECTIVES/HYPOTHESIS: Laryngomalacia is a common cause of newborn stridor. Laryngopharyngeal reflux (LPR) has been associated with laryngomalacia. Although pepsin, a component of LPR, has been associated with inflammatory diseases of the aerodigestive tract, its presence in the airways of laryngomalacia patients is unknown. STUDY DESIGN: Prospective case-control study comparing patients under age 3 years with laryngomalacia to children without laryngomalacia. METHODS: Children less than 3 years old undergoing supraglottoplasty for laryngomalacia or surgery unrelated to the airway, without a history of laryngomalacia, reflux, or respiratory disease, were offered enrollment...
February 22, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28219323/a-preliminary-assessment-of-the-lma-protector%C3%A2-in-non-paralysed-patients
#15
Ban Leong Sng, Farida Binte Ithnin, Deepak Mathur, Eileen Lew, Nian-Lin Reena Han, Alex Tiong-Heng Sia
BACKGROUND: The LMA Protector™ is the latest CE marked single use supraglottic airway device. This airway device provides access and functional separation of the respiratory and digestive tracts. There are two ports (male, female ports) to provide suction in the laryngeal region and insertion of the gastric tube. The aim of our study is to assess the ease of use, airway quality, device positioning, airway leak and complications associated with initial clinical experience in LMA Protector™ usage...
February 20, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28213068/an-unusual-cause-of-severe-dyspnea-a-laryngeal-live-leech-case-report
#16
Said Anajar, Rachid Ansari, Jawad Hassnaoui, Reda Abada, Mohammed Roubal, Mohammed Mahtar
INTRODUCTION: Foreign bodies in the upper airways are one of the most challenging otolaryngology emergencies, leeches present a very rare cause of airway foreign bodies around the world. CASE REPORT: A 6-year-old girl was referred to our otolaryngology department at a tertiary university hospital with a severe dyspnea and hemoptysis. Nasofibroscopy revealed a dark living leech in the supraglottic area which extends to the glottis. The patient was urgently admitted to the operating room, the leech was grasped and removed with a foreign body forceps with a full length of more than 6cm...
January 25, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28203766/vision-guided-placement-of-supraglottic-airway-device-prevents-airway-obstruction-a-prospective-audit
#17
A A J Van Zundert, S P Gatt, C M Kumar, T C R V Van Zundert
No abstract text is available yet for this article.
March 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28202298/blind-intubation-through-supraglottic-devices-a-word-of-caution
#18
Emanuela Parotto, Paolo Persona, Carlo Ori
No abstract text is available yet for this article.
February 4, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28194529/a-randomized-clinical-study-on-postoperative-pain-comparing-between-the-supraglottic-airway-device-and-endotracheal-tubing-in-transabdominal-preperitoneal-repair-tapp
#19
Y Nagahisa, K Hashida, R Matsumoto, R Kawashima, M Okabe, K Kawamoto
BACKGROUND: Transabdominal preperitoneal (TAPP) repair is the most widely used laparoscopic technique for the treatment of inguinal hernia in Japan. Many studies have shown that in comparison with open hernia repair, laparoscopic repair results in less pain and a shorter convalescence. However, postoperative pain remains a concern. One possible cause of postoperative pain in the early postoperative phase is strain or cough on removal of the endotracheal tube. Use of a supraglottic airway (SGA) device helps to avoid such complaints...
February 13, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28177327/functional-outcomes-of-supraglottic-squamous-cell-carcinoma-treated-by-transoral-laser-microsurgery-compared-with-horizontal-supraglottic-laryngectomy-in-patients-younger-and-older-than-65-years
#20
C M Chiesa Estomba, F A Betances Reinoso, A I Lorenzo Lorenzo, J L Fariña Conde, J Araujo Nores, C Santidrian Hidalgo
The treatment of supraglottic carcinoma remains a controversial issue. Five accepted surgical and non-surgical oncological treatments have been currently established: standard horizontal supraglottic laryngectomy (HSL), supraglottic CO2 laser microsurgery (TLM), transoral robotic surgery, radiotherapy alone and radiotherapy in combination with chemotherapy. Some studies have shown that complications of head and neck surgeries increase significantly in patients over 65 years compared to younger patients. We designed a retrospective analysis to assess the rate of complications and functional outcomes of patients treated by TLM and HSL in cases of T1-T3 supraglottic squamous cell carcinomas (SCC) in a tertiary University Hospital...
December 2016: Acta Otorhinolaryngologica Italica
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