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https://www.readbyqxmd.com/read/26376680/efficiency-of-cd19-chimeric-antigen-receptor-modified-t-cells-for-treatment-of-b-cell-malignancies-in-phase-i-clinical-trials-a-meta-analysis
#1
Tengfei Zhang, Ling Cao, Jing Xie, Ni Shi, Zhen Zhang, Zhenzhen Luo, Dongli Yue, Zimeng Zhang, Liping Wang, Weidong Han, Zhongwei Xu, Hu Chen, Yi Zhang
Chimeric antigen receptor (CAR) modified T cells targeted CD19 showed promising clinical outcomes in treatment of B cell malignances such as chronic lymphocytic leukemia (CLL), acute lymphoblastic leukemia (ALL) and other indolent lymphomas. However, the clinical benefit varies tremendously among different trials. This meta-analysis investigated the efficacy (response rates and survival time) of CD19-CAR T cells in refractory B cell malignances in Phase I clinical trials. We searched publications between 1991 and 2014 from PubMed and Web of Science...
October 20, 2015: Oncotarget
https://www.readbyqxmd.com/read/26257045/prognostic-factors-for-outcome-in-localized-extremity-rhabdomyosarcoma-pooled-analysis-from-four-international-cooperative-groups
#2
MULTICENTER STUDY
Odile Oberlin, Annie Rey, Kenneth L B Brown, Gianni Bisogno, Ewa Koscielniak, Michael C G Stevens, Douglas S Hawkins, William H Meyer, Trang H La, Modesto Carli, James R Anderson
BACKGROUND: Extremity rhabdomyosarcomas do not always show satisfactory outcomes. We analyzed data from 643 patients treated in 14 studies conducted by European and North American groups between 1983 and 2004 to identify factors predictive of outcome. PROCEDURE: Clinical factors, including age; histology; site of primary (hand and foot vs. other); size; invasiveness (T stage); nodal involvement (N stage); and treatment factors, including post-surgical group; chemotherapy type and duration; radiotherapy; and treatment (before or after 1995); were evaluated for impact on overall survival (OS)...
December 2015: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/26212714/comparison-of-self-administered-survey-questionnaire-responses-collected-using-mobile-apps-versus-other-methods
#3
REVIEW
José S Marcano Belisario, Jan Jamsek, Kit Huckvale, John O'Donoghue, Cecily P Morrison, Josip Car
BACKGROUND: Self-administered survey questionnaires are an important data collection tool in clinical practice, public health research and epidemiology. They are ideal for achieving a wide geographic coverage of the target population, dealing with sensitive topics and are less resource-intensive than other data collection methods. These survey questionnaires can be delivered electronically, which can maximise the scalability and speed of data collection while reducing cost. In recent years, the use of apps running on consumer smart devices (i...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26079574/mortality-attributable-to-secondhand-smoke-exposure-in-spain-2011
#4
Maria J López, Mónica Pérez-Ríos, Anna Schiaffino, Esteve Fernández
INTRODUCTION: The objective of this study was to assess the mortality attributable to secondhand smoke (SHS) exposure among never-smokers in Spain in 2011, after the implementation of the Spanish smoking law. METHODS: Data on SHS exposure were obtained from a computer-assisted telephone survey carried out in a representative sample of the adult Spanish population. We included the two main diseases widely associated with SHS exposure: lung cancer and ischaemic heart disease...
May 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/25969732/prevalence-of-rheumatoid-arthritis-in-low-and-middle-income-countries-a-systematic-review-and-analysis
#5
Igor Rudan, Simrita Sidhu, Angeliki Papana, Shi-Jiao Meng, Yu Xin-Wei, Wei Wang, Ruth M Campbell-Page, Alessandro Rhyll Demaio, Harish Nair, Devi Sridhar, Evropi Theodoratou, Ben Dowman, Davies Adeloye, Azeem Majeed, Josip Car, Harry Campbell, Wei Wang, Kit Yee Chan
BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune disorder that affects the small joints of the body. It is one of the leading causes of chronic morbidity in high-income countries, but little is known about the burden of this disease in low- and middle-income countries (LMIC). METHODS: The aim of this study was to estimate the prevalence of RA in six of the World Health Organization's (WHO) regions that harbour LMIC by identifying all relevant studies in those regions...
June 2015: Journal of Global Health
https://www.readbyqxmd.com/read/25886303/the-effects-of-the-omagh-bomb-on-adolescent-mental-health-a-school-based-study
#6
Michael Duffy, Maura McDermott, Andrew Percy, Anke Ehlers, David M Clark, Michael Fitzgerald, John Moriarty
BACKGROUND: The main objective of this study was to assess psychiatric morbidity among adolescents following the Omagh car bombing in Northern Ireland in 1998. METHODS: Data was collected within schools from adolescents aged between 14 and 18 years via a self-completion booklet comprised of established predictors of PTSD; type of exposure, initial emotional response, long-term adverse physical problems, predictors derived from Ehlers and Clark's (2000) cognitive model, a PTSD symptoms measure (PDS) and the General Health Questionnaire (GHQ)...
2015: BMC Psychiatry
https://www.readbyqxmd.com/read/25784406/the-effects-of-the-omagh-bomb-on-adolescent-mental-health-a-school-based-study
#7
Michael Duffy, Maura McDermott, Andrew Percy, Anke Ehlers, David M Clark, Michael Fitzgerald, John Moriarty
BACKGROUND: The main objective of this study was to assess psychiatric morbidity among adolescents following the Omagh car bombing in Northern Ireland in 1998. METHODS: Data was collected within schools from adolescents aged between 14 and 18 years via a self-completion booklet comprised of established predictors of PTSD; type of exposure, initial emotional response, long-term adverse physical problems, predictors derived from Ehlers and Clark's (2000) cognitive model, a PTSD symptoms measure (PDS) and the General Health Questionnaire (GHQ)...
December 2015: BMC Psychiatry
https://www.readbyqxmd.com/read/25759947/meta-analysis-of-the-effect-of-goal-directed-therapy-on-bowel-function-after-abdominal-surgery
#8
REVIEW
J C Gómez-Izquierdo, L S Feldman, F Carli, G Baldini
BACKGROUND: Intraoperative goal-directed therapy (GDT) was introduced to titrate intravenous fluids, with or without inotropic drugs, based on objective measures of hypovolaemia and cardiac output measurements to improve organ perfusion. This meta-analysis aimed to determine the effect of GDT on the recovery of bowel function after abdominal surgery. METHODS: MEDLINE, Embase, the Cochrane Library and PubMed databases were searched for randomized clinical trials and cohort studies, from January 1989 to June 2013, that compared patients who did, or did not, receive intraoperative GDT, and reported outcomes on the recovery of bowel function...
May 2015: British Journal of Surgery
https://www.readbyqxmd.com/read/25618013/associations-of-objectively-measured-built-environment-attributes-with-youth-moderate-vigorous-physical-activity-a-systematic-review-and-meta-analysis
#9
REVIEW
Leslie J McGrath, Will G Hopkins, Erica A Hinckson
BACKGROUND: Understanding attributes of the built environment that influence children's and adolescents' habitual physical activity can inform urban design. OBJECTIVE: To conduct a systematic review and meta-analysis of studies linking aspects of the built environment with youth moderate-vigorous activity, including walking. DATA SOURCES: The PubMed, Embase, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases were searched using relevant key words for articles published between January 2000 and March 2013...
June 2015: Sports Medicine
https://www.readbyqxmd.com/read/25610765/volume-of-interest-based-18f-fluorodeoxyglucose-pet-discriminates-mci-converting-to-alzheimer-s-disease-from-healthy-controls-a-european-alzheimer-s-disease-consortium-eadc-study
#10
M Pagani, F De Carli, S Morbelli, J Öberg, A Chincarini, G B Frisoni, S Galluzzi, R Perneczky, A Drzezga, B N M van Berckel, R Ossenkoppele, M Didic, E Guedj, A Brugnolo, A Picco, D Arnaldi, M Ferrara, A Buschiazzo, G Sambuceti, F Nobili
An emerging issue in neuroimaging is to assess the diagnostic reliability of PET and its application in clinical practice. We aimed at assessing the accuracy of brain FDG-PET in discriminating patients with MCI due to Alzheimer's disease and healthy controls. Sixty-two patients with amnestic MCI and 109 healthy subjects recruited in five centers of the European AD Consortium were enrolled. Group analysis was performed by SPM8 to confirm metabolic differences. Discriminant analyses were then carried out using the mean FDG uptake values normalized to the cerebellum computed in 45 anatomical volumes of interest (VOIs) in each hemisphere (90 VOIs) as defined in the Automated Anatomical Labeling (AAL) Atlas and on 12 meta-VOIs, bilaterally, obtained merging VOIs with similar anatomo-functional characteristics...
2015: NeuroImage: Clinical
https://www.readbyqxmd.com/read/25478979/effect-of-restraining-devices-on-eye-injury-in-motor-vehicle-collisions
#11
REVIEW
Kun Hwang, Joo Ho Kim
The aim of this systematic review is to summarize and critically evaluate the evidence for or against the effectiveness of restraining devices on eye injury in motor vehicle collisions (MVCs).In a PubMed search, the search terms "eye injury and seatbelt," "eye injury and car belt," "eye injury and airbag," and "eye injury and restraining" were used. Among the 30 potentially relevant articles, 5 articles met our inclusion criteria. The odds ratio (OR) and 95% confidence intervals (CIs) from each study were abstracted...
January 2015: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/25471485/fracture-risk-in-long-term-care-a-systematic-review-and-meta-analysis-of-prospective-observational-studies
#12
REVIEW
Rasha Khatib, Nancy Santesso, Laura Pickard, Osman Osman, Lora Giangregorio, Carly Skidmore, Alexandra Papaioannou
BACKGROUND: The risk factors associated with fractures have been well-characterized in community dwelling populations, but have not been clearly defined in long-term care (LTC) settings. The objective of this review was to identify risk factors for fractures in LTC settings. METHODS: We searched MEDLINE, the Cochrane Library, EMBASE and CINAHL up to June 2014, scanned reference lists of articles and consulted with experts in the field to identify relevant prospective cohort studies that evaluated risk factors associated with fracture incidence in LTC...
December 3, 2014: BMC Geriatrics
https://www.readbyqxmd.com/read/25429846/efficacy-of-behavioural-interventions-for-transport-behaviour-change-systematic-review-meta-analysis-and-intervention-coding
#13
REVIEW
Bronia Arnott, Lucia Rehackova, Linda Errington, Falko F Sniehotta, Jennifer Roberts, Vera Araujo-Soares
BACKGROUND: Reducing reliance on motorised transport and increasing use of more physically active modes of travel may offer an opportunity to address physical inactivity. This review evaluates the evidence for the effects of behavioural interventions to reduce car use for journeys made by adults and codes intervention development and content. METHODS: The review follows the procedure stated in the registration protocol published in the PROSPERO database (registration number CRD42011001797)...
November 28, 2014: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/25137113/mental-health-first-aid-is-an-effective-public-health-intervention-for-improving-knowledge-attitudes-and-behaviour-a-meta-analysis
#14
Gergö Hadlaczky, Sebastian Hökby, Anahit Mkrtchian, Vladimir Carli, Danuta Wasserman
Mental Health First Aid (MHFA) is a standardized, psychoeducational programme developed to empower the public to approach, support and refer individuals in distress by improving course participants' knowledge, attitudes and behaviours related to mental ill-health. The present paper aims to synthesize published evaluations of the MHFA programme in a meta-analysis to estimate its effects and potential as a public mental health awareness-increasing strategy. Fifteen relevant papers were identified through a systematic literature search...
August 2014: International Review of Psychiatry
https://www.readbyqxmd.com/read/25083763/muscle-versus-fasciocutaneous-free-flaps-in-heel-reconstruction-systematic-review-and-meta-analysis
#15
REVIEW
Carly M Fox, Henry M Beem, Jonathon Wiper, Warren M Rozen, Michael Wagels, James C Leong
BACKGROUND: Management of soft tissue injuries of the heel is challenging and the composition of free tissue transfer that provides optimal aesthetic and functional outcomes in heel reconstruction is not clear. While fasciocutaneous flaps may result in shear planes that cause instability with mobilization, insensate muscle flaps may not be able to withstand the pressures of weight bearing and thus ulcerate. METHODS: A systematic literature search was performed using Medline and PubMed databases...
January 2015: Journal of Reconstructive Microsurgery
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