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Apolipoprotein B

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https://www.readbyqxmd.com/read/28808293/targeting-apolipoprotein-e-amyloid-%C3%AE-binding-by-peptoid-cpo_a%C3%AE-17-21%C3%A2-p-ameliorates-alzheimer-s-disease-related-pathology-and-cognitive-decline
#1
Shan Liu, Shinae Park, Grant Allington, Frances Prelli, Yanjie Sun, Mitchell Martá-Ariza, Henrieta Scholtzova, Goutam Biswas, Bernard Brown, Philip B Verghese, Pankaj D Mehta, Yong-Uk Kwon, Thomas Wisniewski
Inheritance of the apolipoprotein E4 (apoE4) genotype has been identified as the major genetic risk factor for late onset Alzheimer's disease (AD). Studies have shown that apoE, apoE4 in particular, binds to amyloid-β (Aβ) peptides at residues 12-28 of Aβ and this binding modulates Aβ accumulation and disease progression. We have previously shown in several AD transgenic mice lines that blocking the apoE/Aβ interaction with Aβ12-28 P reduced Aβ and tau-related pathology, leading to cognitive improvements in treated AD mice...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28805698/artemisia-iwayomogi-extract-attenuates-high-fat-diet-induced-hypertriglyceridemia-in-mice-potential-involvement-of-the-adiponectin-ampk-pathway-and-very-low-density-lipoprotein-assembly-in-the-liver
#2
Jinhui Lee, Vikram P Narayan, Eun Young Hong, Wan Kyunn Whang, Taesun Park
This study aimed to examine the protective effect of Artemisia iwayomogi extract (AI) against hypertriglyceridemia induced by a high-fat diet (HFD) in mice and to uncover the underlying molecular mechanisms. C57BL/6N mice were fed chow, HFD, HFD + 0.1% AI, HFD + 0.25% AI, or HFD + 0.5% AI for 10 weeks. The addition of 0.25% and 0.5% AI resulted in dose-dependent improvements in the major parameters of hypertriglyceridemia, including plasma triglyceride, free fatty acids, apolipoprotein B, and lipoprotein lipase, with parallel reductions in body weight gain, hepatic lipid accumulation, and insulin resistance...
August 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28798692/change-in-the-lipid-transport-capacity-of-the-liver-and-blood-during-reproduction-in-rats
#3
Yufeng Zhang, Christine Kallenberg, Hayden W Hyatt, Andreas N Kavazis, Wendy R Hood
To support the high energetic demands of reproduction, female mammals display plasticity in many physiological processes, such as the lipid transport system. Lipids support the energy demands of females during reproduction, and energy and structural demands of the developing offspring via the placenta in utero or milk during the suckling period. We hypothesized that key proteins supporting lipid transport in reproductive females will increase during pregnancy and lactation, but drop to non-reproductive levels shortly after reproduction has ended...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28797250/omega-3-fatty-acids-eicosapentaenoic-acid-and-docosahexaenoic-acid-and-their-mechanisms-of-action-on-apolipoprotein-b-containing-lipoproteins-in-humans-a-review
#4
REVIEW
Jan Oscarsson, Eva Hurt-Camejo
BACKGROUND: Epidemiological and genetic studies suggest that elevated triglyceride (TG)-rich lipoprotein levels in the circulation increase the risk of cardiovascular disease. Prescription formulations of omega-3 fatty acids (OM3FAs), mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), reduce plasma TG levels and are approved for the treatment of patients with severe hypertriglyceridemia. Many preclinical studies have investigated the TG-lowering mechanisms of action of OM3FAs, but less is known from clinical studies...
August 10, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28795506/oral-apolipoprotein-a-i-mimetic-d-4f-lowers-hdl-inflammatory-index-in-high-risk-patients-a-first-in-human-multiple-dose-randomized-controlled-trial
#5
Richard L Dunbar, Rajesh Movva, LeAnne T Bloedon, Danielle Duffy, Robert B Norris, Mohamad Navab, Alan M Fogelman, Daniel J Rader
A single dose of the apolipoprotein (apo)A-I mimetic peptide D-4F rendered high-density lipoprotein (HDL) less inflammatory, motivating the first multiple-dose study. We aimed to assess safety/tolerability, pharmacokinetics, and pharmacodynamics of daily, orally administered D-4F. High-risk coronary heart disease (CHD) subjects added double-blinded placebo or D-4F to statin for 13 days, randomly assigned 1:3 to ascending cohorts of 100, 300, then 500 mg (n = 62; 46 men/16 women). D-4F was safe and well-tolerated...
August 9, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28792616/proteomic-profiling-of-liver-and-plasma-in-chronic-ethanol-feeding-model-of-hepatic-alcohol-dehydrogenase-deficient-deer-mice
#6
Kamlesh K Bhopale, Samir M Amer, Lata Kaphalia, Kizhake V Soman, John E Wiktorowicz, G A Shakeel Ansari, Bhupendra S Kaphalia
BACKGROUND: Chronic alcohol abuse, a major risk factor for such diseases as hepatitis and cirrhosis, impairs hepatic alcohol dehydrogenase (ADH, key ethanol metabolizing enzyme). Therefore, differentially altered hepatic and plasma proteomes were identified in chronic ethanol feeding model of hepatic ADH-deficient (ADH(-) ) deer mice to understand the metabolic basis of alcoholic liver disease (ALD). METHODS: ADH(-) deer mice were fed 3.5g% ethanol via Lieber-DeCarli liquid diet daily for three months, and histology of the liver assessed...
August 9, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28792141/validation-of-a-newly-developed-equation-for-estimating-serum-apolipoprotein-b-associations-with-cardiovascular-disease-surrogate-markers-in-koreans
#7
Jong Dai Kim, You Cheol Hwang, Hong Yup Ahn, Cheol Young Park
PURPOSE: Many clinical guidelines recommend apolipoprotein B (apoB) measurement, particularly in subjects with metabolic syndrome or type 2 diabetes. Recently, we developed a new equation to estimate serum apoB (apoBE). We validated the clinical relevance of apoBE and compared the performance of the equation with conventional lipid measurements and direct measurement of apoB. MATERIALS AND METHODS: Study subjects were recruited from patients who visited the Health Screening Center at Kangbuk Samsung Hospital between January and December 2009 for routine medical examinations (n=78125)...
September 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28777337/endoplasmic-reticulum-stress-inducer-tunicamycin-alters-hepatic-energy-homeostasis-in-mice
#8
Bin Feng, Xiaohua Huang, Dandan Jiang, Lun Hua, Yong Zhuo, De Wu
Disorders of hepatic energy metabolism, which can be regulated by endoplasmic reticulum (ER) stress, lead to metabolic diseases such as hepatic steatosis and hypoglycemia. Tunicamycin, a pharmacological ER stress inducer, is used to develop an anti-cancer drug. However, the effects of tunicamycin on hepatic energy metabolism have not been well elucidated. Mice were intraperitoneally injected with tunicamycin or vehicle. Twenty-four hours later, hepatic triglyceride and glycogen content and serum lipids profiles were analyzed, as well as the expression of lipogenic and gluconeogenic genes...
August 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28775061/association-of-high-density-lipoprotein-cholesterol-versus-apolipoprotein-a-i-with-risk-of-coronary-heart-disease-the-european-prospective-investigation-into-cancer-norfolk-prospective-population-study-the-atherosclerosis-risk-in-communities-study-and-the-women
#9
Julian C van Capelleveen, Andrea E Bochem, S Matthijs Boekholdt, Samia Mora, Ron C Hoogeveen, Christie M Ballantyne, Paul M Ridker, Wensheng Sun, Philip J Barter, Alan R Tall, Aeilko H Zwinderman, John J P Kastelein, Nick J Wareham, Kay-Tee Khaw, G Kees Hovingh
BACKGROUND: The contribution of apolipoprotein A-I (apoA-I) to coronary heart disease (CHD) risk stratification over and above high-density lipoprotein cholesterol (HDL-C) is unclear. We studied the associations between plasma levels of HDL-C and apoA-I, either alone or combined, with risk of CHD events and cardiovascular risk factors among apparently healthy men and women. METHODS AND RESULTS: HDL-C and apoA-I levels were measured among 17 661 participants of the EPIC (European Prospective Investigation into Cancer)-Norfolk prospective population study...
August 3, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28775055/in-vivo-imaging-of-venous-side-cerebral-small-vessel-disease-in-older-adults-an-mri-method-at-7t
#10
C E Shaaban, H J Aizenstein, D R Jorgensen, R L MacCloud, N A Meckes, K I Erickson, N W Glynn, J Mettenburg, J Guralnik, A B Newman, T S Ibrahim, P J Laurienti, A N Vallejo, C Rosano
BACKGROUND AND PURPOSE: Traditional neuroimaging markers of small-vessel disease focus on late-stage changes. We aimed to adapt a method of venular assessment at 7T for use in older adults. We hypothesized that poorer venular morphologic characteristics would be related to other small-vessel disease neuroimaging markers and a higher prevalence of small-vessel disease-Alzheimer disease risk factors. MATERIALS AND METHODS: Venules were identified in periventricular ROIs on SWI and defined as tortuous or straight...
August 3, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28774493/prevalence-of-cardiovascular-disease-risk-factors-in-tallinn-estonia
#11
Margit Kaldmäe, Galina Zemtsovskaja, Jelena Abina, Tiit Land, Margus Viigimaa
BACKGROUND AND OBJECTIVE: Cardiovascular diseases are still a major public health concern in Estonia despite the decline in the mortality rate during the past decade. For better preventive strategies we aimed to investigate the prevalence of cardiovascular disease risk factors and their relations with age, gender and ethnicity. MATERIALS AND METHODS: The cross-sectional study was carried out in Tallinn, Estonia. Two hundred individuals from each of the sex and 10-year age group (range 20-65 years of age) were randomly selected and invited to participate...
July 25, 2017: Medicina
https://www.readbyqxmd.com/read/28774484/cardiovascular-disease-risk-associated-with-serum-apolipoprotein-b-is-modified-by-serum-vitamin-a
#12
Thomas Olsen, Kathrine J Vinknes, Gard F T Svingen, Eva R Pedersen, Grethe S Tell, Rune Blomhoff, Christian A Drevon, Per M Ueland, Øivind Midttun, Helga Refsum, Ottar K Nygård
BACKGROUND AND AIMS: Apolipoproteins B (apoB) and A1 (apoA1) are major protein constituents of low-density and high-density lipoproteins, respectively, and serum concentrations of these apolipoproteins are associated with risk of atherosclerosis. Vitamin A (VA) has been implicated in lipoprotein metabolism. We evaluated the associations of serum apoB, apoA1 and their ratio (apoBAR) with risk of incident acute myocardial infarction (AMI) and the possible modification by serum VA. METHODS: Risk associations were assessed by Cox regression, and presented as hazard ratios (HRs) per standard deviation (SD) increment in log-transformed values of the lipid parameters, among 4117 patients with suspected stable angina pectoris, located in Western Norway...
July 21, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28771191/somatic-host-cell-alterations-in-hpv-carcinogenesis
#13
REVIEW
Tamara R Litwin, Megan A Clarke, Michael Dean, Nicolas Wentzensen
High-risk human papilloma virus (HPV) infections cause cancers in different organ sites, most commonly cervical and head and neck cancers. While carcinogenesis is initiated by two viral oncoproteins, E6 and E7, increasing evidence shows the importance of specific somatic events in host cells for malignant transformation. HPV-driven cancers share characteristic somatic changes, including apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC)-driven mutations and genomic instability leading to copy number variations and large chromosomal rearrangements...
August 3, 2017: Viruses
https://www.readbyqxmd.com/read/28770971/apolipoprotein-a1-and-neuronal-nitric-oxide-synthase-gene-polymorphisms-and-hormone-related-osteonecrosis-of-the-femoral-head
#14
L Chen, P Wei, K Jiang, X-X Xia
OBJECTIVE: This study was designed to investigate the influence of several polymorphisms in neuronal NOS genes and apolipoprotein AI on the hormone-related osteonecrosis of the femoral head (ONFH) risk. PATIENTS AND METHODS: Peripheral blood mononuclear cell (PBMCs) samples extracted from hormone-related ONFH patients and controls were used to amplify fragments of the apolipoprotein A1 and neuronal NOS exon 7 and intron 4 using specific PCR primers. The products were analyzed by DNA sequencing and mapped to find the genotype distributions...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28770234/snps-linkage-disequilibrium-and-chronic-mountain-sickness-in-tibetan-chinese
#15
Norman E Buroker, Xue-Han Ning, Zhao-Nian Zhou, Kui Li, Wei-Jun Cen, Xiu-Feng Wu, Wei-Zhong Zhu, C Ronald Scott, Shi-Han Chen
Chronic mountain sickness (CMS) is estimated at 1.2% in Tibetans living at the Qinghai-Tibetan Plateau. Eighteen single-nucleotide polymorphisms (SNPs) from nine nuclear genes that have an association with CMS in Tibetans have been analyzed by using pairwise linkage disequilibrium (LD). The SNPs included are the angiotensin-converting enzyme (rs4340), the angiotensinogen (rs699), and the angiotensin II type 1 receptor (AGTR1) (rs5186) from the renin-angiotensin system. A low-density lipoprotein apolipoprotein B (rs693) SNP was also included...
2017: Hypoxia
https://www.readbyqxmd.com/read/28765208/plasma-cholesterol-level-determines-in-vivo-prion-propagation
#16
Veronique Perrier, Thibaut Imberdis, Pierre-Andre Lafon, Marina Cefis, Yunyun Wang, Elisabeth Huetter, Jacques-Damien Arnaud, Teresa Alvarez-Martinez, Naig Le Guern, Guillaume Maquart, Laurent Lagrost, Catherine Desrumaux
Transmissible spongiform encephalopathies (TSE) are fatal neurodegenerative diseases with an urgent need for therapeutic and prophylactic strategies. At the time when the blood-mediated transmission of prions was demonstrated, in vitro studies indicated a high binding affinity of the scrapie prion protein (PrPSc) with apolipoprotein B-containing lipoproteins, i.e. the main carriers of cholesterol in human blood. The aim of the present study was to explore the relationship between circulating cholesterol-containing lipoproteins and the pathogenicity of prions in vivo...
August 1, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28763400/body-composition-cardiometabolic-risk-factors-physical-activity-and-inflammatory-markers-in-premenopausal-women-after-a-10-year-follow-up-a-monet-study
#17
Sahar Razmjou, Joseph Abdulnour, Jean-Philippe Bastard, Soraya Fellahi, Éric Doucet, Martin Brochu, Jean-Marc Lavoie, Rémi Rabasa-Lhoret, Denis Prud'homme
OBJECTIVE: Menopausal transition and postmenopause are usually associated with changes in body composition and a decrease in physical activity energy expenditure (PAEE). This study investigated body composition, cardiometabolic risk factors, PAEE, and inflammatory markers in premenopausal women after a 10-year follow-up. METHODS: In all, 102 premenopausal women participated in the 5-year observational longitudinal Montreal Ottawa New Emerging Team (MONET) study...
July 31, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28761986/smoking-cessation-reduces-the-lectin-like-low-density-lipoprotein-receptor-index-an-independent-cardiovascular-risk-marker-of-vascular-inflammation
#18
Maki Komiyama, Hiromichi Wada, Koh Ono, Hajime Yamakage, Noriko Satoh-Asahara, Sayaka Shimada, Masaharu Akao, Tatsuya Morimoto, Akira Shimatsu, Yuko Takahashi, Tatsuya Sawamura, Koji Hasegawa
Vessel wall inflammation promotes the destabilization of atherosclerotic plaques. The lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) expressed by vascular cells and monocytes. LOX index is calculated by multiplying LOX-1 ligand containing apolipoprotein B level with the soluble LOX-1. A high LOX index reflects an increased risk for stroke and myocardial infarction. However, the change in LOX index after smoking cessation and the relationship between smoking-related variables and LOX index are unknown...
July 31, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28760743/hypoxia-inducible-protein-2-hig2-hilpda-mediates-neutral-lipid-accumulation-in-macrophages-and-contributes-to-atherosclerosis-in-apolipoprotein-e-deficient-mice
#19
Anja Maier, Hao Wu, Nada Cordasic, Peter Oefner, Barbara Dietel, Christoph Thiele, Alexander Weidemann, Kai-Uwe Eckardt, Christina Warnecke
Recently we identified hypoxia-inducible protein 2 (HIG2)/hypoxia-inducible lipid droplet associated (HILPDA) as lipid droplet (LD) protein. Because HILPDA is highly expressed in atherosclerotic plaques, we examined its regulation and function in murine macrophages, compared it to the LD adipose differentiation-related protein (Adrp)/perilipin 2 (Plin2), and investigated its effects on atherogenesis in apolipoprotein E-deficient (ApoE(-/-)) mice. Tie2-Cre-driven Hilpda knockout (cKO) did not affect viability, proliferation, and ATP levels in macrophages...
July 31, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28759039/elevated-tumor-ldlr-expression-accelerates-ldl-cholesterol-mediated-breast-cancer-growth-in-mouse-models-of-hyperlipidemia
#20
E J Gallagher, Z Zelenko, B A Neel, I M Antoniou, L Rajan, N Kase, D LeRoith
Obesity is associated with an increase in cancer-specific mortality in women with breast cancer. Elevated cholesterol, particularly low-density lipoprotein cholesterol (LDL-C), is frequently seen in obese women. Here, we aimed to determine the importance of elevated circulating LDL, and LDL receptor (LDLR) expression in tumor cells, on the growth of breast cancer using mouse models of hyperlipidemia. We describe two novel immunodeficient mouse models of hyperlipidemia (Rag1(-/)(-)/LDLR(-/)(-) and Rag1(-/)(-)/ApoE (apolipoprotein E)(-/)(-) mice) in addition to established immunocompetent LDLR(-/)(-) and ApoE(-/)(-) mice...
July 31, 2017: Oncogene
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