Jianan Zhao, Lingxia Xu, Kai Wei, Ping Jiang, Cen Chang, Linshuai Xu, Yiming Shi, Yixin Zheng, Yu Shan, Yuejuan Zheng, Yi Shen, Jia Liu, Shicheng Guo, Rongsheng Wang, Dongyi He
OBJECTIVES: Rheumatoid arthritis (RA) is a complex disease with a challenging diagnosis, especially in seronegative patients. The aim of this study is to investigate whether the methylation sites associated with the overall immune response in RA can assist in clinical diagnosis, using targeted methylation sequencing technology on peripheral venous blood samples. METHODS: The study enrolled 241 RA patients, 30 osteoarthritis patients (OA), and 30 healthy volunteers control (HC)...
March 19, 2024: International Immunopharmacology