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Reduced intensity conditioning

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https://www.readbyqxmd.com/read/28454323/microrna-29a-b-c-targets-inos-and-is-involved-in-protective-remote-ischemic-preconditioning-in-an-ischemia-reperfusion-rat-model-of-non-alcoholic-fatty-liver-disease
#1
Yun-Fei Duan, Dong-Lin Sun, Jing Chen, Feng Zhu, Yong An
Remote ischemic preconditioning (RIPC) protects against the injury that is incurred by ischemia and reperfusion (IR); however, the role of RIPC in liver IR injury in non-alcoholic fatty liver disease (NAFLD) remains unclear. In this study, a NAFLD rat model was utilized in a series of different surgical procedures and molecular experiments. Rats of the IR group and the RIPC+IR group exhibited more severe injury than NAFLD control rats (in which the liver was prodded following a median-incision laparotomy). The liver condition, measured by serum alanine transaminase and aspartate transaminase levels, of the RIPC+IR group was better than that of the IR group...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28448465/shadow-based-vehicle-detection-in-urban-traffic
#2
Manuel Ibarra-Arenado, Tardi Tjahjadi, Juan Pérez-Oria, Sandra Robla-Gómez, Agustín Jiménez-Avello
Vehicle detection is a fundamental task in Forward Collision Avoiding Systems (FACS). Generally, vision-based vehicle detection methods consist of two stages: hypotheses generation and hypotheses verification. In this paper, we focus on the former, presenting a feature-based method for on-road vehicle detection in urban traffic. Hypotheses for vehicle candidates are generated according to the shadow under the vehicles by comparing pixel properties across the vertical intensity gradients caused by shadows on the road, and followed by intensity thresholding and morphological discrimination...
April 27, 2017: Sensors
https://www.readbyqxmd.com/read/28447572/effects-of-bone-marrow-derived-msc-transplantation-on-functional-recovery-in-a-rat-model-of-spinal-cord-injury-comparisons-of-transplant-locations-and-cell-concentrations
#3
Jessica J Matyas, Andrew N Stewart, Allison Goldsmith, Zhenhong Nan, Reid L Skeel, Julien Rossignol, Gary L Dunbar
Spinal cord injury (SCI) is a widely disabling condition, constraining those affected by it to wheelchairs and requiring intense daily care and assistance. Cell replacement therapies, targeting regeneration of cells in the injured cord, are currently gaining momentum in the field of SCI research. Previous studies indicate that mesenchymal stem cells (MSCs) can reduce functional deficits through immunomodulation and production of trophic factors in a variety of neurological disorders. The present study assessed the efficacy of transplanted bone marrow-derived MSCs at different concentrations and locations for promoting functional recovery following SCI...
April 26, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28446305/-establishment-of-mouse-model-of-h-2-haploidentical-hematopoietic-stem-cell-transplantation-from-double-donors
#4
Xiao-Na Wang, Yu-Meng Liang, Lei Deng, Lu Wang, Yi Wang, Ya-Jing Huang, Tie-Qiang Liu, Hong-Li Zuo, Kai-Xun Hu, Jian-Hui Qiao, Qi-Yun Sun, Mei Guo, Hui-Sheng Ai, Chang-Lin Yu
OBJECTIVE: To establish a new mouse model of H-2 haploidentical stem cell transplantation from double donors (DHSCT) and compare with conventional haploidentical hematopoietic stem cell transplantation (HSCT) so as to alleviate transplant-related complications. METHODS: The recipients CB6F1 of conventional HSCT group were pretreated by 8 Gy total body irradiation(TBI), and received 3×10(7) donor (male C57) spleen mononuclear cells (spMNC) mobilized by G-CSF within 2 hours after TBI...
April 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28446249/adipose-derived-mesenchymal-stem-cells-modulate-cd14-cd16-expression-on-monocytes-from-sepsis-patients-in-vitro-via-prostaglandin-e2
#5
Guanguan Qiu, Guoping Zheng, Menghua Ge, Lanfang Huang, Haijiang Tong, Ping Chen, Dengming Lai, Yaoqin Hu, Baoli Cheng, Qiang Shu, Jianguo Xu
BACKGROUND: Mesenchymal stem cells (MSCs) have been shown to reduce sepsis-induced inflammation and improve survival in mouse models of sepsis. CD16(+) monocytes are proinflammatory and abundant in inflammatory conditions such as sepsis. The primary objective in this exploratory study was to determine the effects of adipose-derived MSCs (ASCs) on three subsets of monocytes from sepsis patients in vitro and to delineate the underlying mechanism. METHODS: This is a prospective cohort study of patients admitted to the medical intensive care unit (ICU) at an academic medical center...
April 26, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28446144/association-of-physical-activity-and-appetite-with-visual-function-related-to-driving-competence-in-older-adults
#6
Takafumi Ando, Hiroyuki Sakai, Yuji Uchiyama
BACKGROUND: Older people are at greater risk of traffic accidents, partially because of age-related declines in visual function, including reduced useful field of view (UFOV). However, lifestyle factors which cause age-related decline in UFOV remain poorly understood. We conducted a study to investigate whether physical activity and appetite status were related to UFOV test performance in healthy older adults. METHODS: Thirty community-dwelling older people (age 68...
April 26, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28443599/a-pott-s-puffy-tumor-associated-with-epidural-cutaneous-fistula-and-epidural-abscess-case-report
#7
Aleksandar Perić, Milanko Milojević, Dražen Ivetić
BACKGROUND: Pott's puffy tumor is characterized by a fluctuate swelling of the frontal region as a result of osteomyelitis of the frontal bone. This inflammatory lesion may propagate endocranially resulting in acute meningitis, epidural abscess, subdural empyema, cavernous sinus trombophlebitis, cerebritis, and frontal lobe abscess of the brain. CASE REPORT: We present an unusual case of a 33-year-old man suffering from the Pott's puffy tumor whose condition was further complicated by a draining epidural-cutaneous fistula and an epidural abscess...
April 13, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28443389/neuroscience-intermediate-level-care-units-staffed-by-intensivists-clinical-outcomes-and-cost-analysis
#8
Kwadwo Kyeremanteng, Ariel Hendin, Kalpana Bhardwaj, Kednapa Thavorn, Dave Neilipovitz, Dalibour Kubelik, Gianni D'Egidio, Grant Stotts, Erin Rosenberg
INTRODUCTION: With an aging population and increasing numbers of intensive care unit admissions, novel ways of providing quality care at reduced cost are required. Closed neurointensive care units improve outcomes for patients with critical neurological conditions, including decreased mortality and length of stay (LOS). Small studies have demonstrated the safety of intermediate-level units for selected patient populations. However, few studies analyze both cost and safety outcomes of these units...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28442333/effects-of-auditory-stimuli-on-electrical-activity-in-the-brain-during-cycle-ergometry
#9
Marcelo Bigliassi, Costas I Karageorghis, Michael J Wright, Guido Orgs, Alexander V Nowicky
The present study sought to further understanding of the brain mechanisms that underlie the effects of music on perceptual, affective, and visceral responses during whole-body modes of exercise. Eighteen participants were administered light-to-moderate intensity bouts of cycle ergometer exercise. Each exercise bout was of 12-min duration (warm-up [3min], exercise [6min], and warm-down [3min]). Portable techniques were used to monitor the electrical activity in the brain, heart, and muscle during the administration of three conditions: music, audiobook, and control...
April 22, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28441760/supplementation-with-a-polyphenol-rich-extract-perfload-%C3%A2-improves-physical-performance-during-high-intensity-exercise-a-randomized-double-blind-crossover-trial
#10
Julien Cases, Cindy Romain, Cristian Marín-Pagán, Linda H Chung, José Miguel Rubio-Pérez, Caroline Laurent, Sylvie Gaillet, Emmanuelle Prost-Camus, Michel Prost, Pedro E Alcaraz
Workout capacity is energy-production driven. To produce peak metabolic power outputs, the organism predominantly relies more on anaerobic metabolism, but this undoubtedly has a negative and limiting impact on muscle function and performance. The aim of the study was to evaluate if an innovative polyphenol-based food supplement, PerfLoad(®), was able to improve metabolic homeostasis and physical performance during high-intensity exercises under anaerobic conditions. The effect of a supplementation has been investigated on fifteen recreationally-active male athletes during a randomized, double-blind and crossover clinical investigation...
April 24, 2017: Nutrients
https://www.readbyqxmd.com/read/28439945/enhancement-of-cardiomyogenesis-in-murine-stem-cells-by-low-intensity-ultrasound
#11
Ailing Teo, Amir Morshedi, Jen-Chieh Wang, Yufeng Zhou, Mayasari Lim
OBJECTIVES: Low-intensity ultrasound (LIUS) has been shown to enhance bone and cartilage regeneration from stem cells. The ease of its incorporation makes it an attractive mechanical stimulus for not only osteogenesis and chondrogenesis, but also cardiomyogenesis. However, to date, no study has investigated its effects on cardiomyogenesis from embryonic stem cells. METHODS: In this study, murine embryonic stem cells were differentiated via embryoid body formation and plating, and after 3 days they were subjected to daily 10 minutes of LIUS treatment with various conditions: (1) low-pulsed (21 mW/cm(2) , 20% duty cycle), (2) low-continuous, (3) high-pulsed (147 mW/cm(2) , 20% duty cycle), and (4) high-continuous LIUS...
April 25, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28438238/behavioral-activation-versus-cognitive-restructuring-to-reduce-automatic-negative-thoughts-in-anxiety-generating-situations
#12
Elvira Nieto Fernández, Jorge Barraca Mairal
BACKGROUND: Recent studies have compared the efficacy of cognitive intervention compared to behavioral techniques for the treatment of different disorders. In line with that work, the empirical study presented here examined the efficacy of Behavioral Activation (BA) and Cognitive Therapy (CT) on Negative Automatic Thoughts (PANs) elicited in situations generating anxiety. METHOD: Based on a sample of 42 students aged 18 to 21 who took the ISRA B, BADS and EROS, 18 subjects with the highest scores were selected and assigned at random to one of two experimental groups or to a control group...
May 2017: Psicothema
https://www.readbyqxmd.com/read/28436378/outcomes-of-corpectomy-in-patients-with-metastatic-cancer
#13
Grzegorz Guzik
BACKGROUND: The objective of surgical management of spinal metastases is to reduce pain and improve the patient's quality of life. The operation should restore spinal stability and decompress neural structures. One surgical technique is corpectomy followed by vertebral body reconstruction and stabilisation of the spine. The procedure may be performed in patients in overall good health and a good survival prognosis. The aim of this paper is to present the outcomes of surgical management of spinal metastases in patients who underwent corpectomy followed by vertebral body reconstruction and stabilisation of the spine...
January 26, 2017: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28435461/recipient-glycemic-micro-environments-govern-therapeutic-effects-of-mesenchymal-stem-cell-infusion-on-osteopenia
#14
Bing-Dong Sui, Cheng-Hu Hu, Chen-Xi Zheng, Yi Shuai, Xiao-Ning He, Ping-Ping Gao, Pan Zhao, Meng Li, Xin-Yi Zhang, Tao He, Kun Xuan, Yan Jin
Therapeutic effects of mesenchymal stem cell (MSC) infusion have been revealed in various human disorders, but impacts of diseased micro-environments are only beginning to be noticed. Donor diabetic hyperglycemia is reported to impair therapeutic efficacy of stem cells. However, whether recipient diabetic condition also affects MSC-mediated therapy is unknown. We and others have previously shown that MSC infusion could cure osteopenia, particularly in ovariectomized (OVX) mice. Here, we discovered impaired MSC therapeutic effects on osteopenia in recipient type 1 diabetes (T1D)...
2017: Theranostics
https://www.readbyqxmd.com/read/28435312/prevalence-of-chronic-pain-with-neuropathic-characteristics-a-randomized-telephone-survey-among-medical-center-patients-in-kuwait
#15
Nadia Zghoul, Edgar L Ross, Robert R Edwards, Adel Ahmed, Robert N Jamison
BACKGROUND: Chronic pain with neuropathic characteristics is considered to be an international health problem. However, surveys on the actual incidence of neuropathic pain have not been conducted in many Middle East countries, including Kuwait. The aim of this study was to examine the incidence of pain and medical comorbidities among a random sample of patients treated at a large medical center in Kuwait. METHODS: A list of 1,000 patients was created from the hospital medical record system, and a telephone survey was conducted on 759 patients who responded to the phone call, of which 67...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28435045/current-direction-dependent-modulation-of-human-hand-motor-function-by-intermittent-theta-burst-stimulation-itbs
#16
Yuichiro Shirota, Suman Dhaka, Walter Paulus, Martin Sommer
BACKGROUND: Transcranial magnetic stimulation (TMS) with different current directions can activate different sets of neurons. Current direction can also affect the results of repetitive TMS. OBJECTIVE: To test the influence of uni-directional intermittent theta burst stimulation (iTBS) using different current directions, namely posteroanterior (PA) and anteroposterior (AP), on motor behaviour. METHODS: In a cross-over design, PA- and AP-iTBS was applied over the left primary motor cortex in 19 healthy, right-handed volunteers...
April 20, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28435032/clinical-efficacy-of-1-year-intensive-systematic-dietary-manipulation-as-complementary-and-alternative-medicine-therapies-on-female-interstitial-cystitis-bladder-pain-syndrome-patients
#17
Hitoshi Oh-Oka
OBJECTIVE: To evaluate the clinical efficacy of intensive systematic dietary manipulation (ISDM) for female patients with interstitial cystitis (IC)/bladder pain syndrome (BPS) in stable condition who were followed in our hospital. MATERIALS AND METHODS: In cooperation with the nutrition control team, we created a basic IC/BPS diet menu for 1 month. Data regarding daily food intake and food-related symptoms were collected by detailed interview of each patient, we set meal menu to control IC/BPS symptoms and advised the patients to reduce the intake of specific food items to the maximum possible extent...
April 20, 2017: Urology
https://www.readbyqxmd.com/read/28434191/the-effect-of-parotid-gland-sparing-imrt-on-salivary-composition-flow-rate-and-xerostomia-measures
#18
Thomas M Richards, Tara Hurley, Lorna Grove, Kevin J Harrington, Guy H Carpenter, Gordon B Proctor, Christopher M Nutting
OBJECTIVES: To describe parotid gland (PG) saliva organic and inorganic composition and flow rate changes, after curative intensity-modulated radiotherapy (IMRT) for head and neck cancer (HNC) and analyse the relationship between PG saliva analytes and xerostomia measures. METHODS AND MATERIALS: Twenty-six patients recruited to five prospective phase 2 or 3 trials which assessed toxicity and efficacy of IMRT by HNC subsite, provided longitudinal PG salivas. Salivary flow rate, subjective and objective xerostomia measures were prospectively collected and salivas tested for inorganic and organic analytes...
April 23, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28433882/hypothyroidism-following-allogeneic-hematopoietic-stem-cell-transplantation-for-acute-myeloid-leukemia
#19
Michael Medinger, Deborah Zeiter, Dominik Heim, Jörg Halter, Sabine Gerull, André Tichelli, Jakob Passweg, Nicole Nigro
BACKGROUND: Hypothyroidism may complicate allogeneic hematopoietic stem cell transplantation (allo-HSCT); we therefore analyzed risk factors in this study. PATIENTS AND METHODS: We studied 229 patients with acute myeloid leukemia (AML) who underwent an allo-HSCT between 2003 and 2013 with different conditioning regimens (myeloablative, reduced-intensity, chemotherapy-based, or total body irradiation-based). Thyroid-stimulating hormone (TSH) and free thyroxine levels (fT4) were available in 104 patients before and after allo-HSCT...
April 13, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28432393/more-functions-of-torpor-and-their-roles-in-a-changing-world
#20
Julia Nowack, Clare Stawski, Fritz Geiser
Increased winter survival by reducing energy expenditure in adult animals is often viewed as the primary function of torpor. However, torpor has many other functions that ultimately increase the survival of heterothermic mammals and birds. In this review, we summarize new findings revealing that animals use torpor to cope with the conditions during and after natural disasters, including fires, storms, and heat waves. Furthermore, we suggest that torpor, which also prolongs longevity and was likely crucial for survival of mammals during the time of the dinosaur extinctions, will be advantageous in a changing world...
April 21, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
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