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Reduced intensity conditioning

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https://www.readbyqxmd.com/read/29331346/predicting-low-resource-intensity-emergency-department-visits-in-children
#1
Margaret Samuels-Kalow, Alon Peltz, Jonathan Rodean, Matthew Hall, Elizabeth R Alpern, Paul L Aronson, Jay G Berry, Kathy N Shaw, Rustin B Morse, Stephen B Freedman, Eyal Cohen, Harold K Simon, Samir S Shah, Yiannis Katsogridakis, Mark I Neuman
BACKGROUND AND OBJECTIVES: Interventions to reduce frequent emergency department (ED) use in children are often limited by the inability to predict future risk. We sought to develop a population-based model for predicting Medicaid-insured children at risk for high frequency of low-resource intensity (LRI) ED visits. METHODS: Retrospective cohort analysis of Medicaid-insured children (age 1-18 years) included in the MarketScan® Medicaid database with ≥1 ED visit(s) in 2013...
January 10, 2018: Academic Pediatrics
https://www.readbyqxmd.com/read/29330399/geriatric-assessment-and-quality-of-life-in-older-patients-considered-for-allogeneic-hematopoietic-cell-transplantation-a-prospective-risk-factor-and-serial-assessment-analysis
#2
Barbara Deschler, Gabriele Ihorst, Susanne Schnitzler, Hartmut Bertz, Juergen Finke
Allogeneic hematopoietic cell transplantation (alloHCT) in older patients requires the weighing of risks and benefits for this potentially curative treatment while facing age-related limitations. Comprehensive geriatric and quality of life (EORTC QLQ C-30) assessements (CGA/QOL) in addition to disease-specific data were obtained in 108 consecutive patients (≥60 years) pre-HCT, at day +30, +100, and +180. Median follow-up of 106 patients alive at alloHCT was 43.5 months, median age 66 years (range 60-78). Eighty-six (81...
January 12, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29330391/impact-of-antithymocyte-globulin-doses-in-reduced-intensity-conditioning-before-allogeneic-transplantation-from-matched-sibling-donor-for-patients-with-acute-myeloid-leukemia-a-report-from-the-acute-leukemia-working-party-of-european-group-of-bone-marrow-transplantation
#3
Raynier Devillier, Myriam Labopin, Patrice Chevallier, Marie-Pierre Ledoux, Gérard Socié, Anne Huynh, Jean-Henri Bourhis, Jean-Yves Cahn, Gabrielle Roth-Guepin, Ghulam Mufti, Déborah Desmier, Mauricette Michallet, Nathalie Fegueux, Fabio Ciceri, Fréderic Baron, Didier Blaise, Arnon Nagler, Mohamad Mohty
Antithymocyte globulin (ATG) is commonly used for graft-vs.-host disease (GVHD) prophylaxis in unrelated donor allogeneic transplantation (Allo-HSCT). However, its use is still controversial in matched sibling donor (MSD) Allo-HSCT, notably after reduced intensity conditioning (RIC). ATG dose may influence the outcome, explaining in part the discordant conclusions in MSD Allo-HSCT. We, therefore, analyzed the impact of ATG doses in patients with acute myeloid leukemia in first complete remission undergoing RIC Allo-HSCT from a MSD...
January 12, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29330087/comparing-the-antipredator-behaviour-of-two-sympatric-but-not-syntopic-liolaemus-lizards
#4
Javiera Constanzo-Chávez, Mario Penna, Antonieta Labra
The microhabitat preferences of prey animals can modulate how they perceive predation risk, and therefore, their antipredator behaviour. We tested under standardized conditions how microhabitat preferences of two Liolaemus lizards affected their responses when confronted with two types of ambush predators (raptor vs. snake), under two levels of predation risk (low vs. high). These lizard species are sympatric, but not syntopic; L. chiliensis basks on bushes, a complex microhabitat that may provide protection against visual predators, while L...
January 9, 2018: Behavioural Processes
https://www.readbyqxmd.com/read/29329859/effect-of-high-pressure-on-structural-modifications-and-enzymatic-activity-of-a-purified-x-prolyl-dipeptidyl-aminopeptidase-from-streptococcus-thermophilus
#5
M Giannoglou, Z Alexandrakis, Ph Stavros, G Katsaros, P Katapodis, G Nounesis, P Taoukis
PepX aminopeptidase from Streptococcus thermophilus ACA DC 0022, used in Greek Feta cheese manufacturing, was purified. PepX comprises two subunits of equal molecular mass estimated, using SDS-PAGE and native-PAGE electrophoresis, to be 86 kDa. The effects of high pressure processing (100-450 MPa, combined with 20-40 °C) on purified PepX activity and structure were studied. Activation of the enzyme was observed after processing at 100-200 MPa and 20-30 °C. More intense processing conditions led to enzyme inactivation...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29328138/optical-convolution-for-quantitative-phase-retrieval-using-the-transport-of-intensity-equation
#6
Tonmoy Chakraborty, Jonathan C Petruccelli
Propagation-based phase imaging using the transport of intensity equation (TIE) allows rapid, deterministic phase retrieval from defocused images. However, computational solutions to the TIE suffer from significant low-frequency noise artifacts and are unique up to the application of boundary conditions on the phase. We demonstrate that quantitative phase can be imaged directly at the detector for a class of pure-phase samples by appropriately patterning the illumination to solve the TIE through an optical convolution with the source...
January 1, 2018: Applied Optics
https://www.readbyqxmd.com/read/29328048/a-biomechanical-modeling-guided-simultaneous-motion-estimation-and-image-reconstruction-technique-smeir-bio-for-4d-cbct-reconstruction
#7
Xiaokun Huang, You Zhang, Jing Wang
Reconstructing four-dimensional cone-beam computed tomography (4D-CBCT) images directly from respiratory phase-sorted traditional 3D-CBCT projections can capture target motion trajectory, reduce motion artifacts, and reduce imaging dose and time. However, the limited numbers of projections in each phase after phase-sorting decreases CBCT image quality under traditional reconstruction techniques. To address this problem, we developed a simultaneous motion estimation and image reconstruction (SMEIR) algorithm, an iterative method that can reconstruct higher quality 4D-CBCT images from limited projections using an inter-phase intensity-driven motion model...
January 12, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29326895/effects-of-walking-with-hand-held-weights-on-energy-expenditure-and-excess-postexercise-oxygen-consumption
#8
Catherine T Campaña, Pablo B Costa
Walking is not only important to assist in performing daily tasks, but also to gain cardiovascular benefits. Further research on walking is needed to examine the physiological responses to improve health and reduce the risks of cardiovascular disease. The purpose of this study was to compare the energy expenditure (EE) during and after walking exercise with versus without hand-held weights (HHW). Nineteen sedentary women (mean±standard deviation; age, 21±2.7 years, height, 163.1±6.3 cm; body mass, 66.6± 15...
December 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29326124/bortezomib-based-immunosuppression-after-reduced-intensity-conditioning-hematopoietic-stem-cell-transplantation-randomized-phase-ii-results
#9
John Koreth, Haesook T Kim, Paulina B Lange, Samuel J Poryanda, Carol G Reynolds, Sharmila Chamling Rai, Philippe Armand, Corey S Cutler, Vincent T Ho, Brett Glotzbecker, Rushdia Yusuf, Sarah Nikiforow, Yi-Bin Chen, Bimalangshu Dey, Malgorzata McMasters, Jerome Ritz, Bruce R Blazar, Robert J Soiffer, Joseph H Antin, Edwin P Alyea
A prior phase I/II trial of bortezomib/tacrolimus/methotrexate prophylaxis after HLA-mismatched reduced intensity conditioning allogeneic hematopoietic stem cell transplantation documented low acute graft versus host disease incidence, with promising overall and progression-free survival. We performed an open-label 3-arm 1:1:1 phase II randomized-controlled-trial comparing grade II-IV acute graft versus host disease between conventional tacrolimus/methotrexate (A) versus bortezomib/tacrolimus/methotrexate (B); and versus bortezomib/sirolimus/tacrolimus (C), in reduced intensity conditioning allogeneic transplantation recipients lacking HLA-matched related donors...
January 11, 2018: Haematologica
https://www.readbyqxmd.com/read/29324980/traits-determining-the-digestibility-decomposability-relationships-in-species-from-mediterranean-rangelands
#10
Iris Bumb, Eric Garnier, Sylvain Coq, Johanne Nahmani, Maria Del Rey Granado, Olivier Gimenez, Elena Kazakou
Background and Aims: Forage quality for herbivores and litter quality for decomposers are two key plant properties affecting ecosystem carbon and nutrient cycling. Although there is a positive relationship between palatability and decomposition, very few studies have focused on larger vertebrate herbivores while considering links between the digestibility of living leaves and stems and the decomposability of litter and associated traits. The hypothesis tested is that some defences of living organs would reduce their digestibility and, as a consequence, their litter decomposability, through 'afterlife' effects...
January 6, 2018: Annals of Botany
https://www.readbyqxmd.com/read/29324573/allogeneic-hematopoietic-stem-cell-transplantation-for-leukocyte-adhesion-deficiency
#11
Yasuo Horikoshi, Katsutsugu Umeda, Kohsuke Imai, Hiromasa Yabe, Yoji Sasahara, Kenichiro Watanabe, Yukiyasu Ozawa, Yoshiko Hashii, Hidemitsu Kurosawa, Shigeaki Nonoyama, Tomohiro Morio
The clinical outcome of allogeneic hematopoietic stem cell transplantation (HSCT) was retrospectively analyzed in 6 patients with leukocyte adhesion deficiency. Of 3 patients transplanted with myeloablative conditioning, 2 patients had complete chimerism and 1 patient had mixed chimerism. By contrast, all 3 patients transplanted with reduced-intensity conditioning (RIC) had mixed chimerism, one of whom progressed to secondary graft failure. All patients with low-level mixed chimerism and secondary graft failure were rescued by donor lymphocyte infusion or a second HSCT...
January 10, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29324357/a-pilot-study-of-the-role-of-the-claustrum-in-attention-and-seizures-in-rats
#12
Arezou Bayat, Sweta Joshi, Sahar Jahan, Phillip Connell, Komei Tsuchiya, David Chau, Tanvir Syed, Patrick Forcelli, Mohamad Z Koubeissi
OBJECTIVE: The claustrum has been implicated in consciousness, and MRIs of patients with status epilepticus have shown increased claustral signal intensity. In an attempt to investigate the role of claustrum in cognition and seizures, we (1) assessed the effect of high-frequency stimulation (HFS) of the claustrum on performance in the operant chamber; (2) studied interclaustral and claustrohippocampal connectivity through cerebro-cerebral evoked potentials (CCEPs); and (3) investigated the role of claustrum in kainate-induced (KA) seizures...
January 5, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29322276/integrating-direct-observation-and-gps-tracking-to-monitor-animal-behavior-for-resource-management
#13
Chelsey Walden-Schreiner, Yu-Fai Leung, Tim Kuhn, Todd Newburger
Monitoring the behavior of pack animals in protected areas informs management about use patterns and the potential associated negative impacts. However, systematic assessments of behavior are uncommon due to methodological and logistical constraints. This study integrated behavior mapping with GPS tracking, and applied behavior change point analysis, as an approach to monitor the behaviors of pack animals during overnight periods. The integrated approach identified multiple grazing patterns (i.e., locally intense grazing, ambulatory grazing) not feasible through a single methodology alone...
January 10, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29317072/betacaryophyllene-a-phytocannabinoid-as-potential-therapeutic-modality-for-human-sepsis
#14
Angel Meza, Christian Lehmann
Sepsis is a clinical condition resulting from a dysregulated immune response to an infection that leads to organ dysfunction. Despite numerous efforts to optimize treatment, sepsis remains to be the main cause of death in most intensive care units. The endogenous cannabinoid system (ECS) plays an important role in inflammation. Cannabinoid receptor 2 (CB2R) activation is immunosuppressive, which might be beneficial during the hyper-inflammatory phase of sepsis. Beta-caryophyllene (BCP) is a non-psychoactive natural cannabinoid (phytocannabinoid) found in Cannabis sativa and in essential oils of spices and food plants, that acts as a selective agonist of CB2R...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29311035/the-reality-of-disability-multidimensional-poverty-of-people-with-disabled-and-their-families-in-latin-america
#15
Mónica Pinilla-Roncancio
BACKGROUND: Disability and poverty are interconnected and although this relationship has been recognised, there is a lack of empirical evidence to support any possible causal relationship in this topic, particularly in the context of Latin America (LA). HYPOTHESIS: This study tests the hypothesis "Disability increases the risk of multidimensional poverty of people living with disabilities and their families". METHODS: Using national census data from Brazil, Chile, Colombia, Costa Rica and Mexico, the Global Multidimensional Poverty Index (Global MPI) was calculated with the aim of measuring and comparing the levels of multidimensional poverty of people living in households with and without disabled members in the five countries...
December 30, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/29310320/in-situ-synthesized-and-embedded-silver-nanoclusters-into-poly-vinyl-alcohol-borax-hydrogel-as-a-novel-dual-mode-on-and-off-fluorescence-sensor-for-fe-iii-and-thiosulfate
#16
Nahid Pourreza, Matineh Ghomi
Herein, a novel method has been developed for in situ synthesis and embedding of silver nanoclusters (AgNCs) into polyvinyl alcohol and borax hydrogel (PBH) without adding any reducing agent. A three-dimensional network of polyvinyl alcohol and borax is formed, and at the same time the silver ions penetrate into the hydrogel, reduced to silver and trapped into the hydrogel bed. The characteristics of this hydrogel nanocomposite were investigated by energy dispersive X-ray spectroscopy and transmission electron microscopy (TEM)...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29308962/pain-diminishing-effects-of-kinesio%C3%A2-taping-after-median-sternotomy
#17
Rabea Brockmann, Hans-Michael Klein
BACKGROUND: Postoperative pain and severe side effects of opioid analgesics present a clinical challenge after cardio-thoracic surgery. In this study, the impact of Kinesio® taping on postoperative morbidity after median sternotomy was observed. METHODS: Thirty-nine patients (mean age 66 ± 9 years, CI: 63.28; 68.98) who underwent median sternotomy between 09/2014 and 11/2014 participated in this prospective randomized controlled trial. Patients were assigned into a treatment on a non-treatment group...
January 8, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29306084/traffic-accident-severity-analysis-with-rain-related-factors-using-structural-equation-modeling-a-case-study-of-seoul-city
#18
Jonghak Lee, Junghyo Chae, Taekwan Yoon, Hojin Yang
Weather conditions are strongly correlated with traffic accident severity. In particular, rain-related factors are an important cause of traffic accidents due to the poor visibility and reduced friction resulting from slippery road conditions. This paper presents a systematic approach to analyze the extent to which the rainfall intensity and level of water depth are responsible for traffic accidents using Seoul City, Korea, as a case study. The rainfall and traffic accident data over a nine-year period (from 2007 to 2015) for Seoul were analyzed through Structural Equation Modeling to identify the relationships among variables by handling endogenous and exogenous variables simultaneously...
January 3, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29305194/cd34-selection-vs-reduced-intensity-conditioning-and-unmodified-graft-for-allogeneic-hematopoietic-cell-transplantation-in-patients-with-aml-and-mds-50-years
#19
Pere Barba, Rodrigo Martino, Qin Zhou, Christina Cho, Hugo Castro-Malaspina, Sean Devlin, Albert Esquirol, Sergio Giralt, Ann A Jakubowski, Dolores Caballero, Molly Maloy, Esperanza B Papadopoulos, José Luís Piñana, María Laura Fox, Francisco Márquez, David Valcárcel, Carlos Solano, Lucía López-Corral, Jorge Sierra, Miguel-Angel Perales
Reduced-intensity conditioning (RIC) and t-cell depletion (TCD) through CD34+ selection without the use of post-transplant immunosuppression are 2 strategies used to reduce non-relapse mortality (NRM) in older patients after allogeneic hematopoietic cell transplantation (allo-HCT). To compare the efficacy of both approaches (RIC and TCD), we evaluated the outcomes of AML and MDS patients > 50 years who underwent allo-HCT from an HLA-matched donor with one of these strategies. Baseline characteristics were comparable between patients receiving TCD (n=204) and RIC (n=151) except for more unrelated donors (68% vs...
January 2, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29305162/neural-basis-for-reduced-executive-performance-with-hypoxic-exercise
#20
Genta Ochi, Yuhki Yamada, Kazuki Hyodo, Kazuya Suwabe, Takemune Fukuie, Kyeongho Byun, Ippeita Dan, Hideaki Soya
While accumulating evidence suggests positive effects of exercise on executive function, such effects vary with environment. In particular, exercise in a hypoxic environment (hypobaric or normobaric hypoxia), leading to decreased oxygen supply, may dampen or cancel such effects. Thus, we further explore the relation between the effects of hypoxic exercise on executive function and their underlying neural mechanisms by monitoring changes of cortical activation patterns using functional near-infrared spectroscopy (fNIRS)...
January 2, 2018: NeuroImage
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