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Hepatocarcinoma

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https://www.readbyqxmd.com/read/27897307/-occipital-neuralgia-as-the-first-symptom-of-a-hepatocarcinoma
#1
A Velazquez-Benito, E Bellosta-Diago, S Santos-Lasaosa, C Iniguez-Martinez, C Perez-Lazaro
No abstract text is available yet for this article.
December 16, 2016: Revista de Neurologia
https://www.readbyqxmd.com/read/27895771/co-culture-of-hepatoma-cells-with-hepatocytic-precursor-stem-like-cells-inhibits-tumor-cell-growth-and-invasion-by-downregulating-akt-nf-%C3%AE%C2%BAb-expression
#2
Cheng-Jun Sui, Miao Xu, Wei-Qing Li, Jia-Mei Yang, Hong-Zhu Yan, Hui-Min Liu, Chun-Yan Xia, Hong-Yu Yu
Hepatocytic stem cells (HSCs) have inhibitory effects on hepatocarcinoma cells. The present study investigated the effects of HSC activity in hepatocarcinoma cells in vitro. A Transwell co-culture system of hepatocytic precursor (stem-like) WB-F344 cells and hepatoma CBRH-7919 cells was used to assess HSC activity in metastasized hepatoma cells in vitro. Nude mouse xenografts were used to assess HSC activity in vivo. Co-culture of hepatoma CBRH-7919 cells with WB-F344 cells suppressed the growth and colony formation, tumor cell migration and invasion capacity of CBRH-7919 cells...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27886213/promotive-effects-of-bone-morphogenetic-protein-2-on-angiogenesis-in-hepatocarcinoma-via-multiple-signal-pathways
#3
Wei-Han Zuo, Peng Zeng, Xi Chen, Yan-Jun Lu, An Li, Jian-Bin Wu
The effects of Bone morphogenetic protein 2 (BMP-2) on the angiogenesis of hepatocellular carcinoma have not yet been observed and its molecular mechanisms is not clear. We first constructed the recombinant lentivirus vectors expressing small hairpin RNA against BMP-2 gene (LV-SH-BMP2) and the recombinant lentivirus vectors over-expressing BMP-2 (overexpression-LV-BMP2), and then the two recombinant lentivirus vectors were respectively transfected into Hep G2 cells. The Hep G2 cells transfected with LV-SH-BMP2 or overexpression-LV-BMP2 were respectively co-cultured with human umbilical vein endothelial cells (HUVECs) to observe the effects of BMP-2 on HUVECs...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27882064/the-evaluation-and-comparison-of-transcriptionally-targeted-noxa-and-puma-killer-genes-to-initiate-apoptosis-under-cancer-specific-promoter-cxcr1-in-hepatocarcinoma-gene-therapy
#4
Shahryar Khoshtinat Nikkhoi, Hedieh Heydarzadeh, Saeed Ranjbar, Fatemeh Salimi, Masoud Aghaeifard, Seyed Moayed Alavian, Azadeh Reshadmanesh
BACKGROUND: Cancerous cells proliferate as fast as possible without a proper surveillance system. This rapid cell division leads to enormous mutation rates, which help a tumor establish. OBJECTIVES: This study evaluated the potential of inducing apoptosis using Noxa and Puma in a hepatocarcinoma cell line. METHODS: The current study generated two recombinant lentiviruses, pLEX-GCN and pLEX-GCP, bearing Noxa and Puma, respectively. Transduction of both genes to hepatocarcinoma (HepG2) was verified using fluorescent microscopic analysis, western blotting, and quantitative real-time polymerase chain reaction (PCR)...
October 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27878958/inhibition-of-orai1-mediated-ca-2-entry-enhances-chemosensitivity-of-hepg2-hepatocarcinoma-cells-to-5-fluorouracil
#5
Bao-Dong Tang, Xin Xia, Xiao-Fei Lv, Bei-Xin Yu, Jia-Ni Yuan, Xiao-Yi Mai, Jin-Yan Shang, Jia-Guo Zhou, Si-Jia Liang, Rui-Ping Pang
Increasing evidence supports that activation of store-operated Ca(2+) entry (SOCE) is implicated in the chemoresistance of cancer cells subjected to chemotherapy. However, the molecular mechanisms underlying chemoresistance are not well understood. In this study, we aim to investigate whether 5-FU induces hepatocarcinoma cell death through regulating Ca(2+) -dependent autophagy. [Ca(2+) ]i was measured using fura2/AM dye. Protein expression was determined by Western blotting and immunohistochemistry. We found that 5-fluorouracil (5-FU) induced autophagic cell death in HepG2 hepatocarcinoma cells by inhibiting PI3K/AKT/mTOR pathway...
November 23, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27878301/long-non-coding-rna-tuc338-is-functionally-involved-in-sorafenib-sensitized-hepatocarcinoma-cells-by-targeting-rasal1
#6
Weidong Jin, Lei Chen, Xun Cai, Yunxiao Zhang, Jianxin Zhang, Dangdang Ma, Xiong Cai, Tao Fu, Zhengping Yu, Fuxiang Yu, Gang Chen
Development of novel targeted therapy holds promise for conquering chemotherapy resistance, one of major hurdles in current liver cancer treatment. We found that long non-coding RNA TUC338 is involved in the development of hepatocellular carcinoma (HCC) and sorafenib resistance. HCC cell lines were transfected with siTUC338, then cell proliferation and invasion ability were investigated by MTT and Transwell assay. Sorafenib resistance HepG2 cells were generated to test the role of TUC338 in sorafenib sensitivity...
November 15, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27877053/synergistic-activity-of-vorinostat-combined-with-gefitinib-but-not-with-sorafenib-in-mutant-kras-human-non-small-cell-lung-cancers-and-hepatocarcinoma
#7
Victor Jeannot, Benoit Busser, Laetitia Vanwonterghem, Sophie Michallet, Sana Ferroudj, Murat Cokol, Jean-Luc Coll, Mehmet Ozturk, Amandine Hurbin
Development of drug resistance limits the efficacy of targeted therapies. Alternative approaches using different combinations of therapeutic agents to inhibit several pathways could be a more effective strategy for treating cancer. The effects of the approved epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (gefitinib) or a multi-targeted kinase inhibitor (sorafenib) in combination with a histone deacetylase inhibitor (vorinostat) on cell proliferation, cell cycle distribution, apoptosis, and signaling pathway activation in human lung adenocarcinoma and hepatocarcinoma cells with wild-type EGFR and mutant KRAS were investigated...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27871039/synthesis-and-antitumor-activity-of-novel-substituted-uracil-1-n-acetic-acid-ester-derivatives-of-20-s-camptothecins
#8
Di-Zao Li, Qiang-Zhe Zhang, Cun-Ying Wang, Yan-Ling Zhang, Xing-Yu Li, Ji-Tao Huang, Hong-Yan Liu, Zhao-Di Fu, Hua-Xian Song, Jin-Ping Lin, Teng-Fei Ji, Xian-Dao Pan
A series of novel substituted uracil-1'(N)-acetic acid esters (6-20) of camptothecins (CPTs) were synthesized by the acylation method. These new compounds were evaluated for in vitro antitumor activity against tumor cell lines, A549, Bel7402, BGC-823, HCT-8 and A2780. In vitro results showed that most of the derivatives exhibited comparable or superior cytotoxicity compare to CPT (1) and topotecan (TPT, 2), with 12 and 13 possessing the best efficacy. Four compounds, 9, 12, 13 and 16, were selected to be evaluated for in vivo antitumor activity against H22, BGC-823 and Bel-7402 in mice...
November 8, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27870932/investigation-of-the-toxicity-of-bismuth-oxide-nanoparticles-in-various-cell-lines
#9
Mahmoud Abudayyak, Ezgi Öztaş, Merve Arici, Gül Özhan
Nanoparticles have been drawn attention in various fields ranging from medicine to industry because of their physicochemical properties and functions, which lead to extensive human exposure to nanoparticles. Bismuth (Bi)-based compounds have been commonly used in the industrial, cosmetic and medical applications. Although the toxicity of Bi-based compounds was studied for years, there is a serious lack of information concerning their toxicity and effects in the nanoscale on human health and environment. Therefore, we aimed to investigate the toxic effects of Bi (III) oxide (Bi2O3) nanoparticles in liver (HepG2 hepatocarcinoma cell), kidney (NRK-52E kidney epithelial cell), intestine (Caco-2 colorectal adenocarcinoma cell), and lung (A549 lung carcinoma cell) cell cultures...
November 18, 2016: Chemosphere
https://www.readbyqxmd.com/read/27869342/fluorogenic-2d-peptidosheet-unravels-cd47-as-a-potential-biomarker-for-profiling-hepatocellular-carcinoma-and-cholangiocarcinoma-tissues
#10
Yun-Han Ma, Wei-Tao Dou, Yu-Fei Pan, Li-Wei Dong, Ye-Xiong Tan, Xiao-Peng He, He Tian, Hong-Yang Wang
A 2D peptidosheet unravels CD47 as a potential biomarker to image hepatocarcinoma and cholangiocarcinoma cells and tissues. Supramolecular assembly between water-soluble 2D MoS2 and a peptide probe produces the 2D peptidosheet suited for the profiling of hepatocarcinoma and cholangiocarcinoma tissues over healthy tissues on clinical specimens.
November 21, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27864870/hereditary-hemorrhagic-telangiectasia-to-transplant-or-not-to-transplant
#11
Sophie Dupuis-Girod, Elisabetta Buscarini
This report comments the case reported by Muller et al. which describes a combination of at least two different indications for orthotopic liver transplant (OLT) in a same patient: hepatocarcinoma and HHT complicated with severe liver involvement and high output cardiac failure. This case report highlighted that the clear time for OLT in HHT can be difficult to determine. In HHT, if intensive medical approach is not efficient, OLT, has to be considered. In the case of Muller et al., the patient was correctly listed for OLT for a single hepatocellular carcinoma, however, he did not receive a sufficient priority so as to avoid worsening of liver vascular malformations complications...
December 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27859419/physicochemical-and-biological-characteristics-of-the-nanostructured-polysaccharide-iron-hydrogel-produced-by-microorganism-klebsiella-oxytoca
#12
Sedigheh Kianpour, Alireza Ebrahiminezhad, Milad Mohkam, Ali Mohammad Tamaddon, Ali Dehshahri, Reza Heidari, Younes Ghasemi
There is an increasing interest in the nanostructured polysaccharide-iron hydrogel produced by Klebsiella oxytoca. Critical physicochemical and biological characteristics of these nanostructures should be revealed for biomedical applications. Accordingly, an iron reducing strain K. oxytoca, which synthesizes biogenic polysaccharide-iron hydrogel nanoparticles, known as Fe (III)-exopolysaccharide (Fe-EPS) was isolated from a mineral spring. For microbiological identification purpose 16S rRNA sequence analysis and different morphological, physiological, and biochemical characteristics of the isolate were studied...
November 8, 2016: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/27853282/novel-podophyllotoxin-derivatives-as-partial-ppar%C3%AE-agonists-and-their-effects-on-insulin-resistance-and-type-2-diabetes
#13
Xiangming Zhang, Huijuan Liu, Bo Sun, Yan Sun, Weilong Zhong, Yanrong Liu, Shuang Chen, Honglei Ling, Lei Zhou, Xiangyan Jing, Yuan Qin, Ting Xiao, Tao Sun, Honggang Zhou, Cheng Yang
Peroxisome proliferator-activated receptor γ (PPARγ) is recognized as a key regulator of insulin resistance. In this study, we searched for novel PPARγ agonists in a library of structurally diverse organic compounds and determined that podophyllotoxin exhibits partial agonist activity toward PPARγ. Eight novel podophyllotoxin-like derivatives were synthesized and assayed for toxicity and functional activity toward PPARγ to reduce the possible systemic toxic effects of podophyllotoxin and to maintain partial agonist activity toward PPARγ...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27847205/sialylated-%C3%AE-1-6-branched-n-glycans-modulate-the-adhesion-invasion-and-metastasis-of-hepatocarcinoma-cells
#14
Xiao Yu, Yujie Zhao, Liping Wang, Xixi Chen, Zhen Su, Han Zhang, Qingmin Yuan, Shujing Wang
The mouse hepatocarcinoma cell lines Hca-F and Hca-P have been derived from hepatocarcinoma in mice and metastasize only to the lymph node. Hca-F cells displayed greater lymphatic metastasis ability than Hca-P cells. When the two cell lines were compared for cell surface sialylated β1,6 branched N-glycans by flow cytometry using L-PHA and SNA, Hca-F cells were found to express significantly higher levels. To explore the effect of increased sialylated β1,6 branched N-glycans on hepatocarcinoma progression, we inhibit their expression in Hca-F cells by using swainsonine treatment and RNA interference...
November 12, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27836789/evaluation-of-cytotoxicity-of-a-purified-venom-protein-from-naja-kaouthia-nkct1-using-gold-nanoparticles-for-targeted-delivery-to-cancer-cell
#15
Tanmoy Bhowmik, Partha Pratim Saha, Amrita Sarkar, Antony Gomes
In our earlier report, gold nanoparticle (GNP) and snake venom protein toxin NKCT1 were conjugated and primary characteristics were done. In this communication, further characteristics of GNP-NKCT1 were done with TGA, BET, Zeta potential, ICP-MS, FTIR, XPS, and in vitro release kinetics for its physicochemical, molecular nature and bonding. TGA and ICP-MS showed that the number of conjugation was 40 ± 5 to 90 ± 8 NKCT1 per gold nanoparticles. FTIR and XPS corresponding to (CO), (NH), (SS) reformulated the conjugation of GNP with NKCT1...
November 9, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27834930/ttf1-in-the-form-of-nanoparticles-inhibits-angiogenesis-cell-migration-and-cell-invasion-in-vitro-and-in-vivo-in-human-hepatoma-through-stat3-regulation
#16
Bin Xiao, Dongjing Lin, Xuan Zhang, Meilan Zhang, Xuewu Zhang
TTF1-NP (5,2',4'-trihydroxy-6,7,5'-trimethoxyflavone nanoparticles), derived from the traditional Changbai Mountain medicinal plant Sorbaria sorbifolia (SS), has been showed its anti-cancer effect in various liver cancer cell types and tissues. The present study was designed to evaluate the antitumor mechanism of the TTF1-NP against HepG2 hepatoma cells and HepG2 cells-induced hepatocarcinoma (HCC) in nude mouse model. Here we demonstrated that TTF1-NP inhibits tube formation of HUVECs and HepG2 cell migration and invasion, and inhibits tumor growth in nude mice implanted with HepG2 cells through the downregulation of STAT3 protein and activation, along with VEGF, KDR, bFGF, MMP2 and MMP9 levels...
November 10, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27827862/cytotoxic-antitumor-and-immunomodulatory-effects-of-the-water-soluble-polysaccharides-from-lotus-nelumbo-nucifera-gaertn-seeds
#17
Yafeng Zheng, Qi Wang, Weijing Zhuang, Xu Lu, Anca Miron, Tsun-Thai Chai, Baodong Zheng, Jianbo Xiao
Lotus is an edible and medicinal plant, and the extracts from its different parts exhibit various bioactivities. In the present study, the hot water-soluble polysaccharides from lotus seeds (LSPS) were evaluated for their cancer cell cytotoxicity, immunomodulatory and antitumor activities. LSPS showed significant inhibitory effects on the mouse gastric cancer MFC cells, human liver cancer HuH-7 cells and mouse hepatocarcinoma H22 cells. The animal studies showed that LSPS inhibited tumor growth in H22 tumor-bearing mice with the highest inhibition rate of 45...
November 2, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27810556/transporter-occluded-state-conformation-induced-endocytosis-amino-acid-transporter-atb-0-mediated-tumor-targeting-of-liposomes-for-docetaxel-delivery-for-hepatocarcinoma-therapy
#18
Qiuhua Luo, Ping Gong, Mengchi Sun, Longfa Kou, Vadivel Ganapathy, Yongkui Jing, Zhonggui He, Jin Sun
Rapidly proliferating tumor cells upregulate specific amino acid transporters, which hold great potential for tumor-selective drug delivery. Published reports have focused primarily on blocking these transporters as a means of starving the tumor cells of amino acids, but their potential in drug delivery remains understudied. In the present study, we developed liposomes functionalized with lysine and polyoxyethylene stearate conjugate (LPS) to interact with ATB(0,+), an amino acid transporter overexpressed in hepatocarcinoma and the liver cancer cell line HepG2...
November 1, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27799875/cytokine-like-activity-of-liver-type-fatty-acid-binding-protein-l-fabp-inducing-inflammatory-cytokine-interleukin-6
#19
Hyunwoo Kim, Gaae Gil, Siyoung Lee, Areum Kwak, Seunghyun Jo, Ensom Kim, Tam T Nguyen, Sinae Kim, Hyunjhung Jhun, Somi Kim, Miyeon Kim, Youngmin Lee, Soohyun Kim
It has been reported that fatty acid binding proteins (FABPs) do not act only as intracellular mediators of lipid responses but also have extracellular functions. This study aimed to investigate whether extracellular liver type (L)-FABP has a biological activity and to determined serum L-FABP levels in patients with end-stage renal disease (ESRD). We isolated L-FABP complementary deoxyribonucleic acid (cDNA) from the Huh7 human hepatocarcinoma cell line and expressed the recombinant L-FABP protein in Escherichia coli...
October 2016: Immune Network
https://www.readbyqxmd.com/read/27798868/gene-expression-analysis-identifies-specific-patterns-of-dysregulated-molecular-pathways-and-genetic-subgroups-of-human-hepatocellular-carcinoma
#20
Holger G Hass, Ulrich Vogel, Michael Scheurlen, Jürgen Jobst
BACKGROUND: Hepatocellular carcinoma comprises of a group of heterogeneous tumors of different etiologies. The multistep process of liver carcinogenesis involves various genetic and phenotypic alterations. The molecular pathways and driver mutations involved are still under investigation. MATERIALS AND METHODS: DNA micorarray technology was used to identify differentially expressed genes between human hepatocarcinoma and non-tumorous liver tissues to establish a unique specific gene-expression profile independent of the underlying liver disease...
October 2016: Anticancer Research
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