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https://www.readbyqxmd.com/read/29050222/beneficial-effect-of-fluoxetine-treatment-aganist-psychological-stress-is-mediated-by-increasing-bdnf-expression-in-selected-brain-areas
#1
Gongying Li, Ping Jing, Zhidong Liu, Zhiruo Li, Hongxia Ma, Wenzhen Tu, Wei Zhang, Chuanjun Zhuo
SSRI antidepressant fluoxetine is widely used to treat psychological stress related disorders, however the underlying working mechanisms is not fully understood, as SSRIs can rapidly increase the extracellular serotonin levels but it normally takes weeks to reveal their therapeutic effect in the stress-related psychological disorders. Our previous study demonstrated that purely psychological stress without any physic stimuli induces a biphasic change in the expression of brain-derived neurotrophic factor (BDNF), which immediately decrease and then gradually increase after the stress; and that the latter BDNF increase in response to the psychological stress involves the activation of serotonin system...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049512/time-requirements-for-electronic-health-record-use-in-an-academic-ophthalmology-center
#2
Sarah Read-Brown, Michelle R Hribar, Leah G Reznick, Lorinna H Lombardi, Mansi Parikh, Winston D Chamberlain, Steven T Bailey, Jessica B Wallace, Thomas R Yackel, Michael F Chiang
Importance: Electronic health record (EHR) systems have transformed the practice of medicine. However, physicians have raised concerns that EHR time requirements have negatively affected their productivity. Meanwhile, evolving approaches toward physician reimbursement will require additional documentation to measure quality and cost of care. To date, little quantitative analysis has rigorously studied these topics. Objective: To examine ophthalmologist time requirements for EHR use...
October 12, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29049313/study-on-association-of-working-hours-and-occupational-physical-activity-with-the-occurrence-of-coronary-heart-disease-in-a-chinese-population
#3
Yao Ma, Ying-Jun Wang, Bing-Rui Chen, Hao-Jie Shi, Hao Wang, Mohammad Reeaze Khurwolah, Ya-Fei Li, Zhi-Yong Xie, Yang Yang, Lian-Sheng Wang
OBJECTIVE: To explore the association of working hours and occupational physical activity (OPA) with the occurrence of coronary heart disease (CHD) in a Chinese population. METHODS: A total of 595 participants (354 and 241 patients with and without CHD, respectively) aged between 24 and 65 were enrolled in our study, which was conducted at the First Affiliated Hospital of Nanjing Medical University between December 2015 and October 2016. Participant characteristics were collected from face-to-face questionnaires, and logistic regression analysis was conducted to examine the association of working hours and OPA with the occurrence of CHD...
2017: PloS One
https://www.readbyqxmd.com/read/29049153/phd-education-outcomes-results-of-a-national-survey-of-nursing-phd-alumni
#4
Carol Hall Ellenbecker, Chizoba Nwosu, Yuqing Zhang, Suzanne Leveille
AIM: A national survey was conducted to examine the relationship between individual students' experiences and nursing PhD program characteristics and program outcomes. BACKGROUND: In light of the shortage of doctorally prepared nurse scientists and a growth in nursing PhD programs, an examination of the PhD nursing education experience in relation to educational outcomes is timely. METHOD: Data were collected from graduates of a 50 percent random sample of nursing PhD programs in the United States...
November 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29049137/effects-of-dextran-70-and-albumin-on-coagulation-in-experimental-hemorrhage-in-the-guinea-pig
#5
Ulf Schött, Thomas Kander, Peter Bentzer
BACKGROUND: Dextran-70 is a more potent plasma volume expander than albumin but use has been hampered because of it's antithrombotic properties. However, also albumin has antithrombotic properties and little is known about relative effects of these two colloids on coagulation in-vivo when controlling for differences in efficacy as plasma volume expanders. AIM: Compare effects of dextran-70 and albumin on coagulation at a dose resulting in equal plasma volume expansion...
October 18, 2017: Shock
https://www.readbyqxmd.com/read/29049133/hdl-cholesterol-efflux-is-impaired-in-older-patients-with-early-sepsis-a-subanalysis-of-a-prospective-pilot-study
#6
Faheem W Guirgis, Christiaan Leeuwenburgh, Victor Grijalva, Jennifer Bowman, Colleen Kalynych, Lyle Moldawer, Frederick A Moore, Srinivasa T Reddy
BACKGROUND: Proper functioning of high density lipoprotein (HDL) is necessary for protection against sepsis. However, previous work has demonstrated that HDL becomes oxidized and dysfunctional (Dys-HDL) during sepsis. Older (age > 65 years) patients are at particularly high risk of sepsis and poor outcomes from sepsis. STUDY OBJECTIVE: To compare functional properties of HDL (cholesterol efflux capacity and paraoxonase enzyme 1 (PON-1) activity) and Dys-HDL between older (age > 65 years) sepsis patients and older healthy volunteers...
October 18, 2017: Shock
https://www.readbyqxmd.com/read/29049076/fatigue-risk-management-the-impact-of-anesthesiology-residents-work-schedules-on-job-performance-and-a-review-of-potential-countermeasures
#7
Lily R Wong, Erin Flynn-Evans, Keith J Ruskin
Long duty periods and overnight call shifts impair physicians' performance on measures of vigilance, psychomotor functioning, alertness, and mood. Anesthesiology residents typically work between 64 and 70 hours per week and are often required to work 24 hours or overnight shifts, sometimes taking call every third night. Mitigating the effects of sleep loss, circadian misalignment, and sleep inertia requires an understanding of the relationship among work schedules, fatigue, and job performance. This article reviews the current Accreditation Council for Graduate Medical Education guidelines for resident duty hours, examines how anesthesiologists' work schedules can affect job performance, and discusses the ramifications of overnight and prolonged duty hours on patient safety and resident well-being...
October 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29048468/policy-determinants-of-physical-activity-across-the-life-course-a-dedipac-umbrella-systematic-literature-review
#8
Anna Puggina, Katina Aleksovska, Christoph Buck, Con Burns, Greet Cardon, Angela Carlin, Simon Chantal, Donatella Ciarapica, Giancarlo Condello, Tara Coppinger, Cristina Cortis, Sara D'Haese, Marieke De Craemer, Andrea Di Blasio, Sylvia Hansen, Licia Iacoviello, Johann Issartel, Pascal Izzicupo, Lina Jaeschke, Martina Kanning, Aileen Kennedy, Fiona Chun Man Ling, Agnes Luzak, Giorgio Napolitano, Julie-Anne Nazare, Camille Perchoux, Tobias Pischon, Angela Polito, Alessandra Sannella, Holger Schulz, Rhoda Sohun, Astrid Steinbrecher, Wolfgang Schlicht, Walter Ricciardi, Ciaran MacDonncha, Laura Capranica, Stefania Boccia
Background: Despite the large number of studies and reviews available, the evidence regarding the policy determinants of physical activity (PA) is inconclusive. This umbrella systematic literature review (SLR) summarizes the current evidence on the policy determinants of PA across the life course, by pooling the results of the available SLRs and meta-analyses (MAs). Methods: A systematic online search was conducted on MEDLINE, ISI Web of Science, Scopus and SPORTDiscus databases up to April 2016...
October 18, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29048364/protective-effect-of-argan-and-olive-oils-against-lps-induced-oxidative-stress-and-inflammation-in-mice-livers
#9
Soufiane El Kamouni, Riad El Kebbaj, Pierre Andreoletti, Abderrahim El Ktaibi, Issam Rharrassi, Abdelkhalid Essamadi, M'hammed Saïd El Kebbaj, Stéphane Mandard, Norbert Latruffe, Joseph Vamecq, Boubker Nasser, Mustapha Cherkaoui-Malki
Sepsis causes severe dysregulation of organ functions, via the development of oxidative stress and inflammation. These pathophysiological mechanisms are mimicked in mice injected with bacterial lipopolysaccharide (LPS). Here, protective properties of argan oil against LPS-induced oxidative stress and inflammation are explored in the murine model. Mice received standard chow, supplemented with argan oil (AO) or olive oil (OO) for 25 days, before septic shock was provoked with a single intraperitoneal injection of LPS, 16 hours prior to animal sacrifice...
October 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29046489/association-between-rotating-night-shift-work-and-metabolic-syndrome-in-korean-workers-differences-between-8-hour-and-12-hour-rotating-shift-work
#10
Jae-Il Oh, Hyeon Woo Yim
This study aimed to analyze the association between the shift work schedule and metabolic syndrome (MetS). This is a retrospective longitudinal study based on the 2015 health checkup data of 2,090 workers evaluated for MetS in 2010 at a general hospital in Korea. The participants were divided according to their shift work schedule into daytime, three-shift (8-hour rotation), and two-shift (12-hour rotation) workers. The index that indicates the association between the shift work schedule and MetS is the odds ratio (OR) calculated using multivariate logistic regression...
October 19, 2017: Industrial Health
https://www.readbyqxmd.com/read/29045441/comparability-of-activity-monitors-used-in-asian-and-western-country-studies-for-assessing-free-living-sedentary-behaviour
#11
Satoshi Kurita, Shohei Yano, Kaori Ishii, Ai Shibata, Hiroyuki Sasai, Yoshio Nakata, Noritoshi Fukushima, Shigeru Inoue, Shigeho Tanaka, Takemi Sugiyama, Neville Owen, Koichiro Oka
This study aims to compare the outputs of the waist-worn Active style Pro HJA-350IT (ASP; used in studies with Asian populations), the waist-worn ActiGragh™GT3X+ using the normal filter (GT3X+) and the thigh-worn activPAL3 (AP) in assessing adults' sedentary behaviour (total sedentary time, number of breaks) under free-living conditions. Fifty healthy workers wore the three monitors simultaneously during their waking hours on two days, including a work day and a non-work day. Valid data were at least 10 hours of wearing time, and the differences between monitors on the sedentary outputs using the AP as criterion measurement were analyzed by ANOVA...
2017: PloS One
https://www.readbyqxmd.com/read/29045160/taxi-driver-speeding-who-when-where-and-how-a-comparative-study-between-shanghai-and-new-york
#12
Yizhe Huang, Daniel Jian Sun, Juanyu Tang
OBJECTIVE: The three objectives of this study are: 1) To identify the driving style characteristics of taxi drivers in Shanghai and NYC using taxi GPS data and make a comparative analysis; 2) To explore the influence of different driving style characteristics on the frequency of speeding (who and how?) 3) To explore the influence of driving style characteristics, road attributes and environmental factors on the speeding rate (when, where and how?) Methods: This study proposes a Driver-Road-Environment Identification (DREI) method to investigate the determinant factors of taxi speeding violations...
October 18, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29044330/purification-and-characterization-of-a-thermostable-alkaline-cellulase-produced-by-bacillus-licheniformis-380-isolated-from-compost
#13
Évilin G DE Marco, Karina Heck, Emerson T Martos, Sueli T VAN DER Sand
During composting processes, the degradation of organic waste is accomplished and driven by a succession of microbial populations exhibiting a broad range of functional competencies. A total of 183 bacteria, isolated from a composting process, were evaluated for cellulase activity at different temperatures (37, 50, 60, and 70°C) and pH values. Out of the 22 isolates that showed activity, isolate 380 showed the highest cellulase activity. Its ability to produce cellulase was evaluated in culture medium supplemented with carboxymethyl cellulose, microcrystalline cellulose, wheat straw, and rice husk...
October 16, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29043087/sleepiness-while-driving-and-shiftwork-patterns-among-korean-bus-drivers
#14
Seyoung Lee, Hyoung-Ryoul Kim, Junsu Byun, Taewon Jang
BACKGROUND: Sleepiness while driving has been regarded as a major cause of death due to traffic accidents. We compared the degree of sleepiness across five different working time periods (first, morning, post-lunch, afternoon, and last) among Korean bus drivers with different shift types (Daily two shift/Alternating day shift). METHOD: We interviewed 332 bus drivers with two shift types (Daily two shift, 128; Alternating day shift, 204). The questionnaire included demographic information (age, alcohol consumption and history of disease), a sleep disorder diagnosed by a doctor, job duration, the number of workdays in the past month, average working hours per workday and week, sleepiness while driving (Karolinska Sleepiness Scale), and sleeping time for both workdays and off-days...
2017: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29043063/a-survey-of-working-conditions-within-biomedical-research-in-the-united-kingdom
#15
Nick Riddiford
Background: Many recent articles have presented a bleak view of career prospects in biomedical research in the US. Too many PhDs and postdocs are trained for too few research positions, creating a "holding-tank" of experienced senior postdocs who are unable to get a permanent position. Coupled with relatively low salaries and the high levels of pressure to publish in top-tier academic journals, this has created a toxic environment that is perhaps responsible for a recently observed decline in biomedical postdocs in the US, the so-called "postdocalypse"...
2017: F1000Research
https://www.readbyqxmd.com/read/29042389/what-s-up-doc-a-national-cross-sectional-study-of-psychological-wellbeing-of-hospital-doctors-in-ireland
#16
Blánaid Hayes, Lucia Prihodova, Gillian Walsh, Frank Doyle, Sally Doherty
OBJECTIVES: To measure levels of psychological distress, psychological wellbeing and self-stigma in hospital doctors in Ireland. DESIGN: National cross-sectional study of randomised sample of hospital doctors. Participants provided sociodemographic data (age, sex, marital status), work grade (consultant, higher/basic specialist trainee), specialty and work hours and completed well-being questionnaires (the Depression Anxiety Stress Scale, WHO Well-being Index, General Health Questionnaire) and single-item scales on self-rated health and self-stigma...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29041977/perceptions-of-and-barriers-to-family-planning-services-in-the-poorest-regions-of-chiapas-mexico-a-qualitative-study-of-men-women-and-adolescents
#17
Emily Dansereau, Alexandra Schaefer, Bernardo Hernández, Jennifer Nelson, Erin Palmisano, Diego Ríos-Zertuche, Alex Woldeab, Maria Paola Zúñiga, Emma Margarita Iriarte, Ali H Mokdad, Charbel El Bcheraoui
BACKGROUND: In the poorest regions of Chiapas, Mexico, 50.2% of women in need of contraceptives do not use any modern method. A qualitative study was needed to design effective and culturally appropriate interventions. METHODS: We used purposive maximum-variation sampling to select eight municipalities with a high proportion of residents in the poorest wealth quintile, including urban, rural, indigenous, and non-indigenous communities. We conducted 44 focus group discussions with 292 women, adolescent women, and men using semi-structured topic guides...
October 17, 2017: Reproductive Health
https://www.readbyqxmd.com/read/29041908/a-qualitative-study-of-employees-opinions-on-establishing-a-generic-call-centre
#18
Hilde Carin Storhaug, Sara Bjune Mead, Aslak Steinsbekk
BACKGROUND: To investigate opinions among employees at an Out-of-Hours general practitioner (OOH-GP) service and a safety alarm service about the establishment of a generic call-centre. METHODS: Qualitative study using individual and group interviews with 14 employees and managers involved in preparation of a merge into a new generic call-centre. They were asked about their opinions towards establishing a generic call-centre where all contact about unplanned health inquiries from the public had to be done by telephone and how to solve more requests on the phone...
October 17, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/29041445/athermal-silicon-optical-add-drop-multiplexers-based-on-thermo-optic-coefficient-tuning-of-sol-gel-material
#19
Soha Namnabat, Kyung-Jo Kim, Adam Jones, Roland Himmelhuber, Christopher T DeRose, Douglas C Trotter, Andrew L Starbuck, Andrew Pomerene, Anthony L Lentine, Robert A Norwood
Silicon photonics has gained interest for its potential to provide higher efficiency, bandwidth and reduced power consumption compared to electrical interconnects in datacenters and high performance computing environments. However, it is well known that silicon photonic devices suffer from temperature fluctuations due to silicon's high thermo-optic coefficient and therefore, temperature control in many applications is required. Here we present an athermal optical add-drop multiplexer fabricated from ring resonators...
September 4, 2017: Optics Express
https://www.readbyqxmd.com/read/29041305/remote-sensing-of-atmospheric-no2-by-employing-the-continuous-wave-differential-absorption-lidar-technique
#20
Liang Mei, Peng Guan, Zheng Kong
Differential absorption lidar (DIAL) technique employed for remote sensing has been so far based on the sophisticated narrow-band pulsed laser sources, which require intensive maintenance during operation. In this work, a continuous-wave (CW) NO2 DIAL system based on the Scheimpflug principle has been developed by employing a compact high-power CW multimode 450 nm laser diode as the light source. Laser emissions at the on-line and off-line wavelengths of the NO2 absorption spectrum are implemented by tuning the injection current of the laser diode...
October 2, 2017: Optics Express
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