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https://www.readbyqxmd.com/read/27575039/nail-dynamization-for-delayed-union-and-nonunion-in-femur-and-tibia-fractures
#1
Josh Vaughn, Heather Gotha, Eric Cohen, Amanda J Fantry, Ross J Feller, Jake Van Meter, Roman Hayda, Christopher T Born
Femoral and tibial shaft fractures are common injuries in the United States. Since their introduction, reamed intramedullary nails have become the treatment of choice for most of these fractures. However, delayed union and nonunion can complicate treatment in up to 10% of patients. Removal of interlocking screws, or dynamization, can promote fracture healing in cases of delayed union or nonunion. The efficacy of nail dynamization has been reported to range from 19% to 82%. This study was conducted to evaluate the efficacy of dynamization, identify the factors associated with its success or failure, and analyze the cost compared with exchange nailing...
November 1, 2016: Orthopedics
https://www.readbyqxmd.com/read/19056392/fecal-glucocorticoids-reflect-socio-ecological-and-anthropogenic-stressors-in-the-lives-of-wild-spotted-hyenas
#2
Page E Van Meter, Jeffrey A French, Stephanie M Dloniak, Heather E Watts, Joseph M Kolowski, Kay E Holekamp
Our aim was to identify natural and anthropogenic influences on the stress physiology of large African carnivores, using wild spotted hyenas (Crocuta crocuta) as model animals. With both longitudinal data from a single social group, and cross-sectional data from multiple groups, we used fecal glucocorticoids (fGC) to examine potential stressors among spotted hyenas. Longitudinal data from adult members of a group living on the edge of the Masai Mara National Reserve, Kenya, revealed that fGC concentrations were elevated during two periods of social upheaval among adults, especially among younger females; however, prey availability, rainfall, and presence of lions did not influence fGC concentrations among hyenas...
February 2009: Hormones and Behavior
https://www.readbyqxmd.com/read/18486298/hyperbaric-oxygen-improves-rate-of-return-of-spontaneous-circulation-after-prolonged-normothermic-porcine-cardiopulmonary-arrest
#3
Keith Van Meter, Simon Sheps, Fred Kriedt, James Moises, Diana Barratt, Heather Murphy-Lavoie, Paul G Harch, Nicolas Bazan
AIM: This controlled, prospective, randomized porcine study tests the hypothesis that high-dose hyperbaric oxygen (HDHBO2) compared with normobaric oxygen (NBO2) or standard-dose hyperbaric oxygen (SDHBO2), improves return of sustained spontaneous circulation (ROSC) after a normothermic, normobaric, 25-min, non-intervened-upon cardiopulmonary arrest. The study incorporated a direct mechanical ventricular assist device (DMVAD) for open chest continuous cardiac compressions (OCCC) to assist advanced cardiac life support (ACLS)...
August 2008: Resuscitation
https://www.readbyqxmd.com/read/18003960/cetuximab-for-the-treatment-of-colorectal-cancer
#4
RANDOMIZED CONTROLLED TRIAL
Derek J Jonker, Chris J O'Callaghan, Christos S Karapetis, John R Zalcberg, Dongsheng Tu, Heather-Jane Au, Scott R Berry, Marianne Krahn, Timothy Price, R John Simes, Niall C Tebbutt, Guy van Hazel, Rafal Wierzbicki, Christiane Langer, Malcolm J Moore
BACKGROUND: Cetuximab, an IgG1 chimeric monoclonal antibody against epidermal growth factor receptor (EGFR), has activity against colorectal cancers that express EGFR. METHODS: From December 2003 to August 2005, 572 patients who had colorectal cancer expressing immunohistochemically detectable EGFR and who had been previously treated with a fluoropyrimidine, irinotecan, and oxaliplatin or had contraindications to treatment with these drugs underwent randomization to an initial dose of 400 mg of cetuximab per square meter of body-surface area followed by a weekly infusion of 250 mg per square meter plus best supportive care (287 patients) or best supportive care alone (285 patients)...
November 15, 2007: New England Journal of Medicine
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