keyword
https://read.qxmd.com/read/38625582/prevention-and-treatment-of-ischaemic-and-haemorrhagic-stroke-in-people-with-diabetes-mellitus-a-focus-on-glucose-control-and-comorbidities
#1
REVIEW
Simona Sacco, Matteo Foschi, Raffaele Ornello, Federico De Santis, Riccardo Pofi, Michele Romoli
Diabetes mellitus is a significant risk factor for both ischaemic and haemorrhagic stroke, affecting up to a third of individuals with cerebrovascular diseases. Beyond being a risk factor for stroke, diabetes and hyperglycaemia have a negative impact on outcomes after ischaemic and haemorrhagic stroke. Hyperglycaemia during the acute ischaemic stroke phase is associated with a higher risk of haemorrhagic transformation and poor functional outcome, with evidence in favour of early intervention to limit and manage severe hyperglycaemia...
April 16, 2024: Diabetologia
https://read.qxmd.com/read/38625544/intrahepatic-cholestasis-of-pregnancy-and-its-association-with-preeclampsia-and-gestational-diabetes-a-retrospective-analysis
#2
JOURNAL ARTICLE
Huseyin Aytug Avsar, Ufuk Atlıhan, Can Ata, Selcuk Erkılınc
PURPOSE: To evaluate maternal and neonatal outcomes in patients with intrahepatic cholestasis of pregnancy (ICP). METHODS: Patients who gave birth in our hospital between January 2018 and March 2022 were retrospectively reviewed from the hospital database and patient file records. The study comprised 1686 patients, 54 in the ICP group and 1632 controls. Patients who had ICP after 20 weeks of gestation and were monitored and delivered at our facility were enrolled...
April 16, 2024: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/38625535/barriers-to-the-use-of-insulin-therapy-and-potential-solutions-a-narrative-review-of-perspectives-from-the-asia-pacific-region
#3
REVIEW
Roger Chen, Azizul Hasan Aamir, Mohammod Feroz Amin, Pongamorn Bunnag, Siew Pheng Chan, Lixin Guo, Mohammad E Khamseh, Viswanathan Mohan, Nemencio Nicodemus, Anthony Roberts, Tri Juli Edi Tarigan, Kyu-Chang Won, Roopa Mehta
The rising prevalence of type 2 diabetes (T2D) is posing major challenges for the healthcare systems of many countries, particularly in the Asia-Pacific Region, in which T2D can present at younger ages and lower body mass index when compared with Western nations. There is an important role for insulin therapy in the management of T2D in these nations, but available evidence suggests that insulin is under-utilized and often delayed, to the detriment of patient prognosis. The authors of this article gathered as an advisory panel (representative of some of the larger Asia-Pacific nations) to identify their local barriers to insulin use in T2D, and to discuss ways in which to address these barriers, with their outputs summarized herein...
April 16, 2024: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/38625013/risk-factors-for-mortality-among-patients-with-fournier-gangrene-a-systematic-review
#4
REVIEW
Pavan Shet, Ashmit Daiyan Mustafa, Karan Varshney, Lavina Rao, Sameen Sawdagar, Florence McLennan, Siraaj Ansari, Darshan Shet, Niveshan Sivathamboo, Sian Campbell
Background: Fournier gangrene (FG) is a form of necrotizing fasciitis involving the perineal, peri-anal, and genital structures, and has exceptionally high mortality rates. To help in early detection of high-risk patients, we aimed to systematically review factors associated with mortality from FG. Patients and Methods: Searches were conducted in PubMed, Embase and Scopus. In our review, a minimum of five patients were required and this was to exclude studies with exceedingly small sample sizes, such as case reports and small case series, with minimal relevance in comparison to larger scale studies...
April 16, 2024: Surgical Infections
https://read.qxmd.com/read/38623887/the-impact-of-resistance-exercise-training-on-glycemic-control-among-adults-with-type-2-diabetes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#5
REVIEW
Yuwen Wan, Zhanguo Su
Background: The prevalence of type 2 diabetes mellitus (T2DM) presents a challenge for health organizations because of its high likelihood of morbidity and mortality. There is an increasing body of evidence exploring the efficacy of resistance training (RT) alone on glycemic control. Objective: To update the effectiveness of RT on glycosylated hemoglobin (HbA1c) and fasting glucose in adults diagnosed with T2DM. Methods: CINAHL (EBSDCO), PubMed, MEDLINE (Ovid), and EMBASE (Ovid) databases were searched from inception to 30 January 2024...
April 16, 2024: Biological Research for Nursing
https://read.qxmd.com/read/38623264/kidney-histopathology-of-patients-with-hepatitis-c-infection-and-diabetes-mellitus-before-and-after-availability-of-direct-acting-antiviral-therapy
#6
JOURNAL ARTICLE
Vanderlene L Kung, Gabriel Giannini, Cynthia C Nast
INTRODUCTION: Type 2 diabetes mellitus (DM) and diabetic kidney disease are increasing. Hepatitis C infection (HCV) occurs in 1% of the world population and can induce several kidney diseases. DM prevalence is increased in individuals with HCV; however, kidney diseases in those with both DM and HCV have not been assessed. Direct-acting antiviral agents (DAAs) became available for HCV treatment in 2014; it is unknown if DAAs altered the spectrum of kidney disease in patients with DM and HCV...
2024: Glomerular diseases
https://read.qxmd.com/read/38622891/methods-to-predict-heart-failure-in-diabetes-patients
#7
REVIEW
Alexander E Berezin, Tetiana A Berezina, Uta C Hoppe, Michael Lichtenauer, Alexander A Berezin
INTRODUCTION: Type 2 diabetes mellitus (T2DM) is one of the leading causes of cardiovascular disease and powerful predictor for new-onset heart failure (HF). AREAS COVERED: We focus on the relevant literature covering evidence of risk stratification based on imaging predictors and circulating biomarkers to optimize approaches to preventing HF in DM patients. EXPERT OPINION: Multiple diagnostic algorithms based on echocardiographic parameters of cardiac remodeling including global longitudinal strain/strain rate are likely to be promising approach to justify individuals at higher risk of incident HF...
April 15, 2024: Expert Review of Endocrinology & Metabolism
https://read.qxmd.com/read/38622882/role-of-synbiotics-prebiotics-and-probiotics-as-dietary-supplements-in-type-2-diabetes-mellitus-induced-health-complications
#8
REVIEW
Kalpana Baghel, Aamir Khan, Naveen Kango
Diabetes is a metabolic disorder whose prevalence has become a worrying condition in recent decades. Chronic diabetes can result in serious health conditions such as impaired kidney function, stroke, blindness, and myocardial infarction. Despite a variety of currently available treatments, cases of diabetes and its complications are on the rise. This review article provides a comprehensive account of the ameliorative effect of prebiotics and probiotics individually or in combination i.e. synbiotics on health complications induced by Type 2 Diabetes Mellitus (T2DM)...
April 15, 2024: Journal of Dietary Supplements
https://read.qxmd.com/read/38622785/updates-on-disorders-in-curly-hair
#9
REVIEW
Amaris N Geisler, Marta Taye, Jorge Larrondo, Tiffany T Mayo, Crystal Aguh, Amy McMichael, Jamie B MacKelfresh, Loren Krueger
Hair disorders, including central centrifugal cicatricial alopecia (CCCA), traction alopecia (TA), and acquired trichorrhexis nodosa (ATN), commonly occur in individuals with curly textured hair. Curly textured hair in individuals of African descent has unique properties and can present diagnostic and therapeutic challenges. CCCA has been linked to uterine leiomyoma and type 2 diabetes mellitus, as well as fibroproliferation. TA often presents with a fringe sign and can arise from high-tension hairstyles presumed to be protective...
April 15, 2024: International Journal of Dermatology
https://read.qxmd.com/read/38621963/-mechanism-of-traditional-chinese-medicine-in-regulating-nlrp3-inflammasomes-to-alleviate-renal-interstitial-fibrosis-in-diabetic-nephropathy-a-review
#10
JOURNAL ARTICLE
Lin Qiao, Yan Jin, Zhao-An Guo
Diabetic nephropathy(DN), a progressive chronic kidney disease(CKD) induced by diabetes mellitus, is the main cause of end-stage renal disease. Renal interstitial fibrosis(RIF) is an irreversible factor in the progression and deterioration of the renal function in DN. Chronic inflammation has become a key link in the pathogenesis of DN-RIF. The NOD-like receptor thermal protein domain associated protein 3(NLRP3) inflammasome is an important inflammatory regulator regulated by a variety of signals. It promotes the production of pro-inflammatory cytokines and induces renal inflammatory cell infiltration to participate in the process of renal fibrosis, demonstrating a complex mechanism of action...
March 2024: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/38618586/an-experience-in-laboratory-diagnosis-of-fungal-infections-in-covid-19-patients
#11
JOURNAL ARTICLE
Sushma Yadav Boorgula, Sadhana Yelamanchili, Srinivas Kishore Sistla, Lubna Saher, Deepika Gujjarlapudi, Shalini E, Sindhu Devi V, Nageshwar Reddy Duvvur
Introduction  Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has cast a gloom spell on healthcare worldwide, infecting millions of people. Objective  The aim of the present study is to determine the prevalence and review the contributing comorbidities and the precipitating factors leading to the emergence of the fungal infections in COVID-19-affected patients. To assess the utility of different laboratory techniques for confirmation of fungal infections...
April 2024: International Archives of Otorhinolaryngology
https://read.qxmd.com/read/38618383/a-case-report-and-literature-review-of-nonketotic-hyperglycemic-hemichorea
#12
Lisle W Blackbourn, Manjari Uppu, Zeeshan Zubair, Deepak Nair
Nonketogenic hyperglycemic hemichorea, also recognized as diabetic striatopathy, is a rare manifestation of diabetes mellitus. The diagnosis of nonketotic hyperglycemic hemichorea is usually made through imaging along with a corresponding clinical picture. Early identification and treatment can lead to complete resolution of the symptoms and better patient outcomes. Here we present a 49-year-old female patient, with a past medical history of poorly controlled type 2 diabetes mellitus and prior left index finger amputation as a complication of her diabetes, who presented for evaluation of a two-week duration of sudden-onset left upper extremity choreiform movements...
March 2024: Curēus
https://read.qxmd.com/read/38617922/modulating-effects-of-crocin-on-lipids-and-lipoproteins-mechanisms-and-potential-benefits
#13
REVIEW
Habib Yaribeygi, Mina Maleki, Farin Rashid-Farrokhi, Payman Raise Abdullahi, Mohammad Amin Hemmati, Tannaz Jamialahmadi, Amirhossein Sahebkar
Dyslipidemia poses a significant risk to cardiovascular health in both diabetic and non-diabetic individuals. Therefore, it is crucial to normalize lipid homeostasis in order to prevent or minimize complications associated with dyslipidemia. However, pharmacological interventions for controlling lipid metabolism often come with adverse effects. As an alternative, utilizing herbal-based agents, which typically have fewer side effects, holds promise. Crocin, a naturally occurring nutraceutical, has been shown to impact various intracellular pathways, reduce oxidative stress, and alleviate inflammatory processes...
April 15, 2024: Heliyon
https://read.qxmd.com/read/38617792/understanding-the-action-mechanisms-of-metformin-in-the-gastrointestinal-tract
#14
REVIEW
Meihui Cheng, Lili Ren, Xianxian Jia, Jianwei Wang, Bin Cong
Metformin is the initial medication recommended for the treatment of type 2 diabetes mellitus (T2DM). In addition to diabetes treatment, the function of metformin also can be anti-aging, antiviral, and anti-inflammatory. Nevertheless, further exploration is required to fully understand its mode of operation. Historically, the liver has been acknowledged as the main location where metformin reduces glucose levels, however, there is increasing evidence suggesting that the gastrointestinal tract also plays a significant role in its action...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38617433/inflammation-in-diabetes-complications-molecular-mechanisms-and-therapeutic-interventions
#15
REVIEW
Lu Zhao, Haoran Hu, Lin Zhang, Zheting Liu, Yunchao Huang, Qian Liu, Liang Jin, Meifei Zhu, Ling Zhang
At present, diabetes mellitus (DM) has been one of the most endangering healthy diseases. Current therapies contain controlling high blood sugar, reducing risk factors like obesity, hypertension, and so on; however, DM patients inevitably and eventually progress into different types of diabetes complications, resulting in poor quality of life. Unfortunately, the clear etiology and pathogenesis of diabetes complications have not been elucidated owing to intricate whole-body systems. The immune system was responsible to regulate homeostasis by triggering or resolving inflammatory response, indicating it may be necessary to diabetes complications...
April 2024: MedComm
https://read.qxmd.com/read/38617398/gestational-diabetes-mellitus-and-its-effects-on-the-developing-cerebellum-a-narrative-review-on-experimental-studies
#16
REVIEW
Mohammad Javad Saeedi Borujeni, Pilar Codoner Franch, Eulalia Alonso Iglesias, Marie Gombert
Diabetes mellitus during pregnancy is a common complication of gestation, but its effects on the offspring's development are poorly understood. Recently, some studies reported that gestational diabetes mellitus (GDM) impairs cerebellar development, and some genetic alterations have been described as consequences. Cerebellum, one of the hindbrain derived structures in the posterior cranial fossa, plays a crucial role in cognition and behavioral functions. In recent years, some surveys stated that gestational diabetes has adverse effects on the fetus's cerebellum...
2024: Iranian Journal of Child Neurology
https://read.qxmd.com/read/38616994/metabolic-syndrome-and-tendon-disease-a-comprehensive-review
#17
REVIEW
Canhao Lai, Ruichen Li, Weili Tang, Jinyu Liu, Xinfang D X F Duan, Dingsu Bao, Huan Liu, Shijie Fu
Metabolic syndrome (MS) is a multifaceted pathological condition characterized by the atypical accumulation of various metabolic components such as central obesity or excess weight, hyperlipidemia, low-density lipoprotein (LDL), hypertension, and insulin resistance. Recently, MS has been recognized as a notable contributor to heart and circulatory diseases. In addition, with increasing research, the impact of MS on tendon repair and disease has gradually emerged. Recent studies have investigated the relationship between tendon healing and diseases such as diabetes, dyslipidemia, obesity, and other metabolic disorders...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38616993/diversities-of-mechanism-in-patients-with-vhl-syndrome-and-diabetes-a-report-of-two-cases-and-literature-review
#18
Yanlei Wang, Zhaoxiang Liu, Wenhui Zhao, Chenxiang Cao, Luqi Xiao, Jianzhong Xiao
BACKGROUND: Von Hippel-Lindau (VHL) syndrome is characterized by tumorous lesions affecting multiple organs. Pancreatic involvement in VHL syndrome can present as endocrine tumors and pancreatic cysts, which can interfere with both exocrine and endocrine functions of the pancreas. Diabetes is an uncommon complication of VHL syndrome. PURPOSE: This study aims to summarize the various mechanisms of diabetes in VHL syndrome by reporting two cases and conducting a literature review...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38616989/can-adipokine-fam19a5-be-a-biomarker-of-metabolic-disorders
#19
REVIEW
Agnieszka Wesołek-Leszczyńska, Katarzyna Pastusiak, Paweł Bogdański, Monika Szulińska
AIM: One of the most critical functions of adipose tissue is the production of adipokines, ie, numerous active substances that regulate metabolism. One is the newly discovered FAM19A5, whose older name is TAFA-5. PURPOSE: The study aimed to review the literature on the FAM19A5 protein. METHODS: The review was conducted in December 2023 using the PubMed (Medline) search engine. Sixty-four papers were included in the review. RESULTS: This protein exhibits the characteristics of an adipokine with positive features for maintaining homeostasis...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38616679/strategies-for-improving-impaired-osseointegration-in-compromised-animal-models
#20
JOURNAL ARTICLE
J Deng, C Van Duyn, D J Cohen, Z Schwartz, B D Boyan
Implant osseointegration is reduced in patients with systemic conditions that compromise bone quality, such as osteoporosis, disuse syndrome, and type 2 diabetes. Studies using rodent models designed to mimic these compromised conditions demonstrated reduced bone-to-implant contact (BIC) or a decline in bone mineral density. These adverse effects are a consequence of disrupted intercellular communication. A variety of approaches have been developed to compensate for the altered microenvironment inherent in compromised conditions, including the use of biologics and implant surface modification...
April 15, 2024: Journal of Dental Research
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