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Dopamine and motivation

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https://www.readbyqxmd.com/read/29434542/norepinephrine-in-the-medial-pre-frontal-cortex-supports-accumbens-shell-responses-to-a-novel-palatable-food-in-food-restricted-mice-only
#1
Emanuele Claudio Latagliata, Stefano Puglisi-Allegra, Rossella Ventura, Simona Cabib
Previous findings from this laboratory demonstrate: (1) that different classes of addictive drugs require intact norepinephrine (NE) transmission in the medial pre Frontal Cortex (mpFC) to promote conditioned place preference and to increase dopamine (DA) tone in the nucleus accumbens shell (NAc Shell); (2) that only food-restricted mice require intact NE transmission in the mpFC to develop conditioned preference for a context associated with milk chocolate; and (3) that food-restricted mice show a significantly larger increase of mpFC NE outflow then free fed mice when experiencing the palatable food for the first time...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29434375/bidirectional-and-long-lasting-control-of-alcohol-seeking-behavior-by-corticostriatal-ltp-and-ltd
#2
Tengfei Ma, Yifeng Cheng, Emily Roltsch Hellard, Xuehua Wang, Jiayi Lu, Xinsheng Gao, Cathy C Y Huang, Xiao-Yan Wei, Jun-Yuan Ji, Jun Wang
Addiction is proposed to arise from alterations in synaptic strength via mechanisms of long-term potentiation (LTP) and depression (LTD). However, the causality between these synaptic processes and addictive behaviors is difficult to demonstrate. Here we report that LTP and LTD induction altered operant alcohol self-administration, a motivated drug-seeking behavior. We first induced LTP by pairing presynaptic glutamatergic stimulation with optogenetic postsynaptic depolarization in the dorsomedial striatum, a brain region known to control goal-directed behavior...
February 12, 2018: Nature Neuroscience
https://www.readbyqxmd.com/read/29429048/peptide-yy-causes-apathy-like-behavior-via-the-dopamine-d2-receptor-in-repeated-water-immersed-mice
#3
Chihiro Yamada, Sachiko Mogami, Hitomi Kanno, Tomohisa Hattori
Apathy is observed across several neurological and psychiatric conditions; however, its pathogenesis remains unclear. We clarified the involvement of brain-gut signaling in the disruption of goal-directed behavior. Male C57BL/6J mice were exposed to water immersion (WI) stress for 3 days. Food intake and nesting behavior were measured as indexes of motivation. Repeated WI caused decrease in food intake and nesting behavior. Plasma levels of peptide YY (PYY), IL-6, and ratio of dopamine metabolites in the striatum were significantly elevated after WI...
February 10, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29427292/intranasal-oxytocin-modulates-neural-functional-connectivity-during-human-social-interaction
#4
James K Rilling, Xiangchuan Chen, Xu Chen, Ebrahim Haroon
Oxytocin (OT) modulates social behavior in primates and many other vertebrate species. Studies in non-primate animals have demonstrated that, in addition to influencing activity within individual brain areas, OT influences functional connectivity across networks of areas involved in social behavior. Previously, we used fMRI to image brain function in human subjects during a dyadic social interaction task following administration of either intranasal oxytocin (INOT) or placebo, and analyzed the data with a standard general linear model...
February 10, 2018: American Journal of Primatology
https://www.readbyqxmd.com/read/29427080/amphetamine-primes-enhanced-motivation-toward-uncertain-choices-in-rats-with-genetic-alcohol-preference
#5
Ville Oinio, Mikko Sundström, Pia Bäckström, Johanna Uhari-Väänänen, Kalervo Kiianmaa, Atso Raasmaja, Petteri Piepponen
RATIONALE: Comorbidity with gambling disorder (GD) and alcohol use disorder (AUD) is well documented. OBJECTIVE: The purpose of our study was to examine the influence of genetic alcohol drinking tendency on reward-guided decision making behavior of rats and the impact of dopamine releaser D-amphetamine on this behavior. METHODS: In this study, Alko alcohol (AA) and Wistar rats went through long periods of operant lever pressing training where the task was to choose the profitable of two options...
February 9, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29426846/contributions-of-pavlovian-incentive-motivation-to-cue-potentiated-feeding
#6
Andrew T Marshall, Briac Halbout, Angela T Liu, Sean B Ostlund
Cues signaling the availability of palatable food acquire the ability to potentiate food seeking and consumption. The current study employed a combination of behavioral, pharmacological, and analytical techniques to probe the role of Pavlovian incentive motivation in cue-potentiated feeding. We show that a cue paired with sucrose solution (CS+) can transfer its control over feeding to stimulate sucrose consumption at a new receptacle, and that this effect depends on activation of D1 dopamine receptors, which is known to modulate other forms of cue-motivated behavior but not taste palatability...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29425730/high-and-low-nightly-running-behavior-associates-with-nucleus-accumbens-n-methyl-d-aspartate-receptor-nmdar-nr1-subunit-expression-and-nmdar-functional-differences
#7
Kolter B Grigsby, Cathleen M Kovarik, George E Rottinghaus, Frank W Booth
The extent to which N-Methyl-D-aspartate (NMDA) receptors facilitate the motivation to voluntarily wheel-run in rodents has yet to be determined. In so, we utilized female Wistar rats selectively bred to voluntarily run high (HVR) and low (LVR) nightly distances in order to examine if endogenous differences in nucleus accumbens (NAc) NMDA receptor expression and function underlies the propensity for high or low motivation to voluntarily wheel-run. 12-14 week old HVR and LVR females were used to examine: 1.) NAc mRNA and protein expression of NMDA subunits NR1, NR2A and NR2B; 2...
February 6, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29422782/the-role-of-ovarian-hormones-and-the-medial-amygdala-in-sexual-motivation
#8
Mary K Holder, Jessica A Mong
Purpose: Although research into the neurobiology of sexual desire in women is active, relatively little is understood about the origins of sexual motivation in women. The purpose of our review is to discuss factors that influence a central sexual motivate state and generalized arousal as potential drivers of sexual motivation in women and female rats. Recent Findings: Sexual motivation is the product of interactions of the central motive state and salient sexually-relevant cues...
December 2017: Current Sexual Health Reports
https://www.readbyqxmd.com/read/29408363/dopamine-depletion-shifts-behavior-from-activity-based-reinforcers-to-more-sedentary-ones-and-adenosine-receptor-antagonism-reverses-that-shift-relation-to-ventral-striatum-darpp32-phosphorylation-patterns
#9
Laura López-Cruz, Noemí San Miguel, Carla Carratalá-Ros, Lidón Monferrer, John D Salamone, Mercè Correa
The mesolimbic dopamine (DA) system plays a critical role in behavioral activation and effort-based decision-making. DA depletion produces anergia (shifts to low effort options) in animals tested on effort-based decision-making tasks. Caffeine, the most consumed stimulant in the world, acts as an adenosine A1/A2A receptor antagonist, and in striatal areas DA D1 and D2 receptors are co-localized with adenosine A1 and A2A receptors respectively. In the present work, we evaluated the effect of caffeine on anergia induced by the VMAT-2 inhibitor tetrabenazine (TBZ), which depletes DA...
February 2, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29407461/co-localization-patterns-of-neurotensin-receptor-1-and-tyrosine-hydroxylase-in-brain-regions-involved-in-motivation-and-social-behavior-in-male-european-starlings
#10
Devin P Merullo, Jeremy A Spool, Changjiu Zhao, Lauren V Riters
Animals communicate in distinct social contexts to convey information specific to those contexts, such as sexual or agonistic motivation. In seasonally-breeding male songbirds, seasonal changes in day length and increases in testosterone stimulate sexually-motivated song directed at females for courtship and reproduction. Dopamine and testosterone may act in the same brain regions to stimulate sexually-motivated singing. The neuropeptide neurotensin, acting at the neurotensin receptor 1 (NTR1), can strongly influence dopamine transmission...
January 30, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29379966/conceptualizing-addiction-from-an-osteopathic-perspective-dopamine-homeostasis
#11
Dave Baron, Kenneth Blum, Anthony Chen, Mark Gold, Rajendra D Badgaiyan
Addiction is a public health crisis in the United States. Understanding the cause and providing effective treatment for patients-in particular, those with substance use disorders-is challenging. Research has demonstrated that addiction is not a flaw in one's moral fiber or a disease of choice; rather, it is driven by alterations in neuronal mechanisms, especially those that involve the neurotransmitter dopamine, which plays a critical role in the brain's reward pathway. Much of osteopathic philosophy is based on the concept of total body homeostasis and allostasis...
February 1, 2018: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/29377365/neonatal-exposure-to-estradiol-increases-dopaminergic-transmission-in-nucleus-accumbens-and-morphine-induced-conditioned-place-preference-in-adult-female-rats
#12
Christian Bonansco, Jonathan Martínez-Pinto, Roxana A Silva, Victoria B Velásquez, Andrés Martorell, Mónica V Selva, Pedro Espinosa, Pablo R Moya, Gonzalo Cruz, María Estela Andrés, Ramón Sotomayor-Zárate
Steroid sex hormones produce physiological effects in reproductive tissues and also in non-reproductive tissues such as the brain, particularly in cortical, limbic and midbrain areas. Dopamine (DA) neurons involved in processes such as prolactin secretion (tuberoinfundibular system), motor circuit regulation (nigrostriatal system) and driving of motivated behavior (mesocorticolimbic system), are specially regulated by sex hormones. Indeed, sex hormones promote neurochemical and behavioral effects induced by drugs of abuse by tuning midbrain DA neurons in adult animals...
January 29, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29371321/role-of-anterior-intralaminar-nuclei-of-thalamus-projections-to-dorsomedial-striatum-in-incubation-of-methamphetamine-craving
#13
Xuan Li, Kailyn Witonsky, Olivia M Lofaro, Felicia Surjono, Jianjun Zhang, Jennifer M Bossert, Yavin Shaham
Relapse to methamphetamine (Meth) seeking progressively increases after withdrawal from drug self-administration (incubation of Meth craving). We previously demonstrated a role of dorsomedial striatum (DMS) dopamine D1 receptors (D1Rs) in this incubation. Here, we studied the role of afferent glutamatergic projections into DMS and local D1R-glutamate interaction in this incubation in male rats.We first measured projection-specific activation on day 30 relapse test by using CTb (retrograde tracer) + Fos (activity marker) double-labeling in projection areas...
January 25, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29367407/an-interaction-between-serotonin-receptor-signaling-and-dopamine-enhances-goal-directed-vigor-and-persistence-in-mice
#14
Matthew R Bailey, Olivia Goldman, Estefanía P Bello, Muhammad O Chohan, Nuri Jeong, Vanessa Winiger, Eileen Chun, Elke Schipani, Abigail Kalmbach, Joseph F Cheer, Peter D Balsam, Eleanor H Simpson
The functionally selective 5HT-2C receptor ligand SB242084 can increase motivation and have rapid onset anti-depressant like effects. We sought to identify the specific behavioural effects of SB242084 treatment and elucidate the mechanism in female and male mice. Using a quantitative behavioural approach we determined that SB242084 increases the vigor and persistence of goal-directed activity across different types of physical work, particularly when work requirements are demanding. We found this influence of SB242084 on effort, rather than reward to be reflected in striatal dopamine measured during behavior...
January 24, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29355335/the-neuroscience-of-cognitive-motivational-styles-sign-and-goal-trackers-as-animal-models
#15
Martin Sarter, Kyra B Phillips
Cognitive-motivational styles describe predominant patterns of processing or biases that broadly influence human cognition and performance. Here we focus on the impact of cognitive-motivational styles on the response to cues predicting the availability of food or addictive drugs. An individual may preferably conduct an analysis of the motivational significance of reward cues, with the result that such cues per se are perceived as rewarding and worth approaching and working for. Alternatively, a propensity for a "cold" analysis of the behavioral utility of a reward cue may yield search behavior for food or drugs but not involve cue approach...
January 22, 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29335538/speed-related-activation-in-the-mesolimbic-dopamine-system-during-the-observation-of-driver-view-videos
#16
Hiroyuki Sakai, Takafumi Ando, Norihiro Sadato, Yuji Uchiyama
Despite the ubiquity and importance of speeding offenses, there has been little neuroscience research regarding the propensity for speeding among vehicle drivers. In the current study, as a first attempt, we examined the hypothesis that visual inputs during high-speed driving would activate the mesolimbic dopaminergic system that plays an important role in mediating motivational craving. To this end, we used functional magnetic resonance imaging to identify speed-related activation changes in mesolimbic dopaminergic regions during the observation of driver-view videos in two groups that differed in self-reported speeding propensity...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29316800/pro-dopamine-regulator-kb220z-attenuates-hoarding-and-shopping-behavior-in-a-female-diagnosed-with-sud-and-adhd
#17
Thomas McLaughlin, Kenneth Blum, Bruce Steinberg, Edward J Modestino, Lyle Fried, David Baron, David Siwicki, Eric R Braverman, Rajendra D Badgaiyan
Background Addictive-like behaviors (e.g., hoarding and shopping) may be the result of the cumulative effects of dopaminergic and other neurotransmitter genetic variants as well as elevated stress levels. We, therefore, propose that dopamine homeostasis may be the preferred goal in combating such challenging and unwanted behaviors, when simple dopaminergic activation through potent agonists may not provide any resolution. Case presentation C.J. is a 38-year-old, single, female, living with her mother. She has a history of substance use disorder as well as attention deficit hyperactivity disorder, inattentive type...
January 10, 2018: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/29307710/nucleus-accumbens-subnuclei-regulate-motivated-behavior-via-direct-inhibition-and-disinhibition-of-vta-dopamine-subpopulations
#18
Hongbin Yang, Johannes W de Jong, YeEun Tak, James Peck, Helen S Bateup, Stephan Lammel
Mesolimbic dopamine (DA) neurons play a central role in motivation and reward processing. Although the activity of these mesolimbic DA neurons is controlled by afferent inputs, little is known about the circuits in which they are embedded. Using retrograde tracing, electrophysiology, optogenetics, and behavioral assays, we identify principles of afferent-specific control in the mesolimbic DA system. Neurons in the medial shell subdivision of the nucleus accumbens (NAc) exert direct inhibitory control over two separate populations of mesolimbic DA neurons by activating different GABA receptor subtypes...
January 17, 2018: Neuron
https://www.readbyqxmd.com/read/29307543/neurotensin-speeds-inhibition-of-dopamine-neurons-through-temporal-modulation-of-gabaa-and-gabab-receptor-mediated-synaptic-input
#19
Christopher W Tschumi, Michael J Beckstead
Midbrain dopamine neurons play physiological roles in many processes including reward learning and motivated behavior, and are tonically inhibited by γ-aminobutyric acid (GABA)ergic input from multiple brain regions. Neurotensin (NT) is a neuropeptide which acutely modulates midbrain dopamine neuron excitability through multiple mechanisms, one of which is a decrease of GABA-mediated inhibition. However, the mechanisms through which NT depresses GABA signaling are not known. Here we used whole cell patch-clamp electrophysiology of dopamine neurons in mouse brain slices to show that NT acts both presynaptically to increase GABAA and postsynaptically to decrease GABAB receptor-mediated currents in the substantia nigra...
January 4, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29289718/a-high-fat-high-sugar-western-diet-alters-dorsal-striatal-glutamate-opioid-and-dopamine-transmission-in-mice
#20
Brandon M Fritz, Braulio Muñoz, Fuqin Yin, Casey Bauchle, Brady K Atwood
Understanding neuroadaptations involved in obesity is critical for developing new approaches to treatment. Diet-induced neuroadaptations within the dorsal striatum have the capacity to drive excessive food seeking and consumption. Five week old C57BL/6J mice consumed a high-fat, high-sugar 'western diet' (WD) or a control 'standard diet' (SD) for 16 weeks. Weight gain, glucose tolerance, and insulin tolerance were measured to confirm an obese-like state. Following these 16 weeks, electrophysiological recordings were made from medium spiny neurons (MSNs) in the medial (DMS) and lateral (DLS) portions of dorsal striatum to evaluate diet effects on neuronal excitability and synaptic plasticity...
December 28, 2017: Neuroscience
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