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https://www.readbyqxmd.com/read/29458107/wnt-receptor-signalling-in-lung-physiology-and-pathology
#1
REVIEW
Wioletta Skronska-Wasek, Reinoud Gosens, Melanie Königshoff, Hoeke Abele Baarsma
The WNT signalling cascades have emerged as critical regulators of a wide variety of biological aspects involved in lung development as well as in physiological and pathophysiological processes in the adult lung. WNTs (secreted glycoproteins) interact with various transmembrane receptors and co-receptors to activate signalling pathways that regulate transcriptional as well as non-transcriptional responses within cells. In physiological conditions, the majority of WNT receptors and co-receptors can be detected in the adult lung...
February 16, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29457539/vocalization-development-in-common-marmosets-for-neurodegenerative-translational-modeling
#2
Corinne A Jones, Mary K Duffy, Sarah A Hoffman, Nancy J Schultz-Darken, Katarina M Braun, Michelle R Ciucci, Marina E Emborg
Objectives In order to facilitate the study of vocalizations in emerging genetic common marmoset models of neurodegenerative disorders, we aimed to analyze call-type changes across age in a translational research environment. We hypothesized that acoustic parameters of vocalizations would change with age, reflecting growth of the vocal apparatus and a maturation of control needed to make adult-like calls. Methods Nineteen developing common marmosets were longitudinally video- and audio-recorded between the ages of 1-149 days in a naturalistic setting without any vocalization elicitation protocol...
February 19, 2018: Neurological Research
https://www.readbyqxmd.com/read/29456906/health-communication-experiences-of-emerging-adults-with-type-1-diabetes
#3
MaryJane Simms, Katherine Baumann, Maureen Monaghan
Objective: In an effort to refine a model of clinical care identifying effective communication with health care providers (HCPs) as a key skill for successful transition to adult medical care, this study explored the perspectives of emerging adults with type 1 diabetes (T1D) about factors that impact the quality and content of communication with their HCPs. Methods: Twenty emerging adults with T1D were interviewed about health communication experiences with their pediatric HCP and readiness for transition to adult diabetes care...
December 2017: Clinical Practice in Pediatric Psychology
https://www.readbyqxmd.com/read/29456516/the-socio-communicative-development-of-preterm-infants-is-resistant-to-the-negative-effects-of-parity-on-maternal-responsiveness
#4
Ivete F R Caldas, Marilice F Garotti, Victor K M Shiramizu, Antonio Pereira
Humans are born completely dependent on adult care for survival. To get the necessary support, newborns rely on socio-communicative abilities which have both innate and learned components. Maternal responsiveness (MR), as a critical aspect of mother-infant interaction, is a robust predictor of the acquisition of socio-communicative abilities. However, maternal responsiveness (MR) is influenced by parity, since mothers rely on a limited capacity of cognitive control for efficient attachment with their offspring...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29456495/structural-variation-of-chondroitin-sulfate-chains-contributes-to-the-molecular-heterogeneity-of-perineuronal-nets
#5
Shinji Miyata, Satomi Nadanaka, Michihiro Igarashi, Hiroshi Kitagawa
Aggrecan, a chondroitin sulfate (CS) proteoglycan, forms lattice-like extracellular matrix structures called perineuronal nets (PNNs). Neocortical PNNs primarily ensheath parvalbumin-expressing inhibitory neurons (parvalbumin, PV cells) late in brain development. Emerging evidence indicates that PNNs promote the maturation of PV cells by enhancing the incorporation of homeobox protein Otx2 and regulating experience-dependent neural plasticity. Wisteria floribunda agglutinin (WFA), an N-acetylgalactosamine-specific plant lectin, binds to the CS chains of aggrecan and has been widely used to visualize PNNs...
2018: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/29456427/the-experience-of-diabetes-related-language-in-diabetes-care
#6
Jane K Dickinson
Objective: The goal of this study was to understand how adults with diabetes experience the words used in diabetes care. Methods: This qualitative study guided by Critical Theory used two virtual and two in-person focus groups conducted by the same facilitator. A total of 68 focus group members participated. The facilitator transcribed and coded focus group data using individual responses as the unit of analysis. The facilitator used constant comparison to analyze responses and developed a research summary of themes that emerged...
February 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29456425/reasons-for-open-and-closed-attitudes-regarding-type-1-diabetes
#7
Jamie K Easler, Helena M Haueter, Susanne Olsen Roper, Donna Freeborn, Tina Dyches
Thirty-one adults with type 1 diabetes participated in this qualitative study to explore reasons why they were willing (had an open attitude) or unwilling (had a closed attitude) to disclose diabetes-related information to others. Participants (61.3% female, mean age 38.48 years, mean duration of diabetes 21.94 years, 100% white) answered open-ended questions about living with type 1 diabetes. Interviews were transcribed verbatim and coded to identify major patterns that emerged in the data. Reasons for open attitudes included support from others, confidence and feeling comfortable, feeling normal despite diabetes, seeking to educate, and feeling that it was not a major concern to share information with others...
February 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29455866/cognition-action-trade-offs-reflect-organization-of-attention-in-infancy
#8
Sarah E Berger, Regina T Harbourne, Melissa N Horger
This chapter discusses what cognition-action trade-offs in infancy reveal about the organization and developmental trajectory of attention. We focus on internal attention because this aspect is most relevant to the immediate concerns of infancy, such as fluctuating levels of expertise, balancing multiple taxing skills simultaneously, learning how to control attention under variable conditions, and coordinating distinct psychological domains. Cognition-action trade-offs observed across the life span include perseveration during skill emergence, errors and inefficient strategies during decision making, and the allocation of resources when attention is taxed...
2018: Advances in Child Development and Behavior
https://www.readbyqxmd.com/read/29455698/stop-the-bleed-the-effect-of-hemorrhage-control-education-on-laypersons-willingness-to-respond-during-a-traumatic-medical-emergency
#9
Elliot M Ross, Theodore T Redman, Julian G Mapp, Derek J Brown, Kaori Tanaka, Craig W Cooley, Chetan U Kharod, David A Wampler
BACKGROUND: The "Stop the Bleed" campaign advocates for non-medical personnel to be trained in basic hemorrhage control. However, it is not clear what type of education or the duration of instruction needed to meet that requirement. The objective of this study was to determine the impact of a brief hemorrhage control educational curriculum on the willingness of laypersons to respond during a traumatic emergency. METHODS: This "Stop the Bleed" education initiative was conducted by the University of Texas Health San Antonio Office of the Medical Director (San Antonio, Texas USA) between September 2016 and March 2017...
February 19, 2018: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29455437/live-donor-liver-transplantation-for-acute-liver-failure-a-single-center-experience
#10
Siddharth Mehrotra, Naimish Mehta, Prashantha S Rao, Shailendra Lalwani, Vivek Mangla, Samiran Nundy
INTRODUCTION: Acute liver failure (ALF) is an indication for emergency liver transplantation (LT). Although centers performing only deceased donor liver transplants (DDLT) have shown improved outcomes in this situation, they still have relatively long waiting lists. An alternative would be living donor liver transplantation (LDLT), which has shown equivalent outcomes in the elective situation but there is limited evidence of its results in ALF. AIM: The purpose of this study was to assess the outcomes in patients with ALF undergoing emergency LDLT in our center in Delhi, India...
February 17, 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/29455323/financial-preparation-for-retirement-in-brazil-a-cross-cultural-test-of-the-interdisciplinary-financial-planning-model
#11
Lucia H F França, Douglas A Hershey
In this investigation, we attempt to replicate the Interdisciplinary Financial Planning Model advanced by Hershey et al. (International Journal of Aging and Human Development, 70, 1-38, 2010) using a sample of Brazilian adults. This model, which was originally tested on individuals from The Netherlands and the United States, posits that psychological, social, and economic forces are key determinants of retirement planning practices and perceptions of saving adequacy. Taken together, fifteen hypotheses were subject to evaluation...
February 17, 2018: Journal of Cross-cultural Gerontology
https://www.readbyqxmd.com/read/29455034/preoperative-risk-factors-for-unexpected-postoperative-intensive-care-unit-admission-a-retrospective-case-analysis
#12
Joshua B Knight, Evan E Lebovitz, Theresa A Gelzinis, Ibtesam A Hilmi
INTRODUCTION: The purpose of this retrospective case-control study was to investigate preoperative risk factors for unexpected postoperative intensive care unit (ICU) admissions in patients undergoing non-emergent surgical procedures in a tertiary medical centre. METHODS: A medical record review of adult patients undergoing elective non-cardiac and non-transplant major surgical procedures during the period of January 2011 through December 2015 in the operating rooms of a large university hospital was carried out...
February 15, 2018: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29454761/diagnostic-accuracy-of-cardiovascular-magnetic-resonance-in-acute-myocarditis-a-systematic-review-and-meta-analysis
#13
Christos P Kotanidis, Maria-Anna Bazmpani, Anna-Bettina Haidich, Charalambos Karvounis, Charalambos Antoniades, Theodoros D Karamitsos
OBJECTIVES: The purpose of this systematic review was to explore the diagnostic accuracy of various cardiovascular magnetic resonance (CMR) index tests for the diagnosis of acute myocarditis in adult patients. BACKGROUND: Acute myocarditis remains one of the most challenging diagnoses in cardiology. CMR has emerged as the diagnostic tool of choice to detect acute myocardial injury and necrosis in patients with suspected myocarditis. METHODS: We considered all diagnostic cohort and case-control studies...
February 9, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29454475/does-childhood-neglect-contribute-to-violent-behavior-in-adulthood-a-review-of-possible-links
#14
REVIEW
Vikki J Bland, Ian Lambie, Charlotte Best
Child neglect, whether intentional or unintentional on the part of caregivers, has serious and far-reaching negative consequences for children. Neglect is the most prevalent form of child maltreatment and has been associated with impaired cognitive development, changes in brain structure and nervous systems, behavioral and personality disorders and poor academic performance. However, the role of child neglect, and subtypes of neglect, in the development of adult violent behavior is not well understood. The "cycle of violence" hypothesis, which predicts that individuals exposed to child physical abuse are more likely to be physically violent in adulthood, is well supported by the literature...
February 9, 2018: Clinical Psychology Review
https://www.readbyqxmd.com/read/29454015/why-i-eat-at-night-a-qualitative-exploration-of-the-development-maintenance-and-consequences-of-night-eating-syndrome
#15
James A Shillito, James Lea, Stephanie Tierney, Jacqueline Cleator, Sara Tai, John P H Wilding
Night Eating Syndrome (NES), as a diagnosis, presents as a combination of disordered eating, sleep and mood. Patients identified as having both NES and obesity demonstrate poorer outcomes in terms of weight loss compared to those with NES only. However, research focusing on psychological factors associated with NES remains relatively underdeveloped. This study aimed to explore the relationship between NES and the experience of emotion from the perspective of patients accessing a weight management service. Ten adults who met diagnostic criteria for moderate or full NES took part in a semi-structured interview...
February 14, 2018: Appetite
https://www.readbyqxmd.com/read/29453739/how-is-civic-engagement-related-to-personal-identity-and-social-identity-in-late-adolescents-and-emerging-adults-a-person-oriented-approach
#16
Lyda Lannegrand-Willems, Basilie Chevrier, Cyrille Perchec, Alexia Carrizales
Adolescence and emerging adulthood are periods in life when individuals both question and define their place in society and form their identity. Meanwhile, active youth civic engagement represents a challenge for each democracy. The purpose of this study was to analyze the different forms of civic engagement among late adolescents and emerging adults and how they are related to personal identity and social identity, while adopting an integrative perspective through the lens of a person-oriented approach. The participants were 1217 (62...
February 16, 2018: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/29453628/safety-tolerability-and-preliminary-activity-of-imgn529-a-cd37-targeted-antibody-drug-conjugate-in-patients-with-relapsed-or-refractory-b-cell-non-hodgkin-lymphoma-a-dose-escalation-phase-i-study
#17
Anastasios Stathis, Ian W Flinn, Sumit Madan, Kami Maddocks, Arnold Freedman, Steven Weitman, Emanuele Zucca, Mihaela C Munteanu, M Lia Palomba
Background CD37 is expressed on B-cell lymphoid malignancies, thus making it an attractive candidate for targeted therapy in non-Hodgkin lymphoma (NHL). IMGN529 is an antibody-drug conjugate comprising a CD37-binding antibody linked to the maytansinoid DM1, a potent anti-mitotic agent. Methods This first-in-human, phase 1 trial recruited adult patients with relapsed or refractory B-cell NHL. The primary objective was to determine the maximum tolerated dose (MTD) and recommended phase 2 dose. Secondary objectives were to evaluate safety, pharmacokinetics, and preliminary clinical activity...
February 17, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29453568/a-method-for-in-vivo-induction-and-ultrastructural-detection-of-mitophagy-in-sertoli-cells
#18
Nabil Eid, Yuko Ito, Akio Horibe, Hitomi Hamaoka, Yoichi Kondo
An emerging body of evidences based on in vitro studies indicate that mitophagy (selective autophagic clearance of damaged mitochondria) is a prosurvival mechanism, specifically under exposure to various stressors. Sertoli cells (SCs) play essential roles in maintenance of spermatogenesis via paracrine interactions with germ cells and other somatic cells in the testis; however, studies investigating mitophagy in SCs are still very few. In this chapter, we give a brief review of mechanisms and detection methods of mitophagy in SCs based on our recent publications on animal models of ethanol toxicity and current literature...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29453396/bone-marrow-lympho-myeloid-malfunction-in-obesity-requires-precursor-cell-autonomous-tlr4
#19
Ailing Liu, Minhui Chen, Rashmi Kumar, Maja Stefanovic-Racic, Robert M O'Doherty, Ying Ding, Willi Jahnen-Dechent, Lisa Borghesi
Obesity, a prevalent condition in adults and children, impairs bone marrow (BM) function. However, the underlying mechanisms are unclear. Here, we show that obese mice exhibit poor emergency immune responses in a toll-like receptor 4 (TLR4)-dependent manner. Canonical myeloid genes (Csf1r, Spi1, Runx1) are enhanced, and lymphoid genes (Flt3, Tcf3, Ebf1) are reduced. Using adoptive transfer and mixed BM chimera approaches we demonstrate that myeloid>lymphoid bias arises after 6 weeks of high-fat diet and depends on precursor cell-autonomous TLR4...
February 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29453191/a-text-message-intervention-with-adaptive-goal-support-to-reduce-alcohol-consumption-among-non-treatment-seeking-young-adults-non-randomized-clinical-trial-with-voluntary-length-of-enrollment
#20
Brian Suffoletto, Tammy Chung, Frederick Muench, Peter Monti, Duncan B Clark
BACKGROUND: Stand-alone text message-based interventions can reduce binge drinking episodes (≥4 drinks for women and ≥5 drinks for men) among nontreatment-seeking young adults, but may not be optimized. Adaptive text message support could enhance effectiveness by assisting context-specific goal setting and striving, but it remains unknown how to best integrate it into text message interventions. OBJECTIVE: The objective of this study was to evaluate young adults' engagement with a text message intervention, Texting to Reduce Alcohol Consumption 2 (TRAC2), which focuses on reducing weekend alcohol consumption...
February 16, 2018: JMIR MHealth and UHealth
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