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https://www.readbyqxmd.com/read/28633762/usefulness-of-mean-platelet-volume-to-lymphocyte-ratio-for-predicting-angiographic-no-reflow-and-short-term-prognosis-after-primary-percutaneous-coronary-intervention-in-patients-with-st-segment-elevation-myocardial-infarction
#1
Alparslan Kurtul, Sadik Kadri Acikgoz
Primary percutaneous coronary intervention (pPCI) is associated with improved prognosis in patients with ST-segment elevation myocardial infarction (STEMI). However, no-reflow phenomenon limits the benefit of revascularization and predicts adverse outcomes. The specific mechanism for its occurrence is still not entirely clear, and it is believed at present that platelet activation and inflammation play a pivotal role in developing no-reflow. Both increased mean platelet volume (MPV), which is a platelet activation marker, and lymphopenia, which is an inflammation marker, have been linked to adverse events and poor prognosis after STEMI...
May 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28623012/p-wave-peak-time-a-novel-electrocardiographic-parameter-in-the-assessment-of-coronary-no-reflow
#2
Metin Çağdaş, Süleyman Karakoyun, İbrahim Rencüzoğulları, Yavuz Karabağ, Mahmut Yesin, Mustafa Ozan Gürsoy, İnanç Artaç, Doğan İliş, Süleyman Çağan Efe, Onur Taşar, Gürkan Karaca
OBJECTIVES: Coronary no-reflow (NR) following primary percutaneous coronary intervention (pPCI) is associated with worsened prognosis in patients with ST segment elevation myocardial infarction (STEMI). Despite rapid developments in cardiovascular area; there are limited data regarding prediction of NR before pPCI. P wave duration and dispersion (PWD, PWDIS, respectively) have been studied in STEMI patients and found to be associated with reperfusion success; however none of them has been found to predict NR before PCI...
June 8, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28617765/cardioprotective-effects-of-nicorandil-on-coronary-heart-disease-patients-undergoing-elective-percutaneous-coronary-intervention
#3
Zhihua Pang, Wei Zhao, Zhuhua Yao
BACKGROUND Nicorandil is a nicotinamide ester commonly prescribed for treatment of patients with coronary heart disease (CHD). In the present study, we aimed to explore the cardioprotective effects of nicorandil on CHD patients undergoing elective percutaneous coronary intervention (PCI). MATERIAL AND METHODS One hundred patients with CHD undergoing PCI were randomly divided into a control group (n=48) and a nicorandil group (n=52). Patients in the control group received traditional therapy, and while patients in the nicorandil group received nicorandil before PCI in addition to the traditional therapy...
June 15, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28613283/risk-factors-for-no-reflow-phenomenon-after-percutaneous-coronary-intervention-in-patients-with-acute-coronary-syndrome
#4
Tian Liang, Min Liu, Chengyu Wu, Qing Zhang, Lei Lu, Zhongliang Wang
BACKGROUND: To explore risk factors for no-reflow phenomenon after percutaneous coronary intervention in patients with acute coronary syndrome. METHODS: A total of 733 acute myocardial infarction patients with persistent ischemic chest pain within 12 or 12-24 hours after onset received emergency percutaneous coronary intervention. Patients were divided into a normal reflow group and a no-reflow group, according to TIMI grading and myocardial blush grading after percutaneous coronary intervention...
May 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28592591/identification-of-high-risk-patients-after-st-segment-elevation-myocardial-infarction-comparison-between-angiographic-and-magnetic-resonance-parameters
#5
COMPARATIVE STUDY
Alessandro Durante, Alessandra Laricchia, Giulia Benedetti, Antonio Esposito, Alberto Margonato, Ornella Rimoldi, Francesco De Cobelli, Antonio Colombo, Paolo G Camici
BACKGROUND: The incidence of angiographic no reflow (NR) and microvascular obstruction (MVO) at cardiac magnetic resonance is significantly different. The aim of this study was to investigate the occurrence of NR and MVO in a cohort of consecutive patients with ST-segment-elevation myocardial infarction treated with primary percutaneous coronary interventions. METHODS AND RESULTS: In this prospective study, 88 consecutive ST-segment-elevation myocardial infarction patients were enrolled within 12 hours from symptoms onset...
June 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28583820/impact-of-platelet-inhibition-level-on-subsequent-no-reflow-in-patients-undergoing-primary-percutaneous-coronary-intervention-for-st-segment-elevation-myocardial-infarction
#6
Omar Aitmokhtar, Franck Paganelli, Saida Benamara, Adel Azaza, Laurent Bonello, Ouafa Hamza, Saber Seddiki, Tayeb Benathmane, Mourad Saidane, Ahmed Bouzid, Maamar Kara, Arezki Sik, Abdelmalek Azzouz, Faiza Harbi, Jean-Jacques Monsuez, Salim Benkhedda
BACKGROUND: High P2Y12 platelet reactivity (PR) level after primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI) affects prognosis and may induce the no-reflow phenomenon. AIM: To investigate the role of PR in the genesis of microvascular obstruction. METHODS: Patients with STEMI undergoing PPCI within 12hours of symptoms onset were included prospectively. All patients received a 600mg clopidogrel-loading dose before PPCI and 250mg aspirin...
June 2, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28562325/hsp-27-levels-and-thrombus-burden-relate-to-clinical-outcomes-in-patients-with-st-segment-elevation-myocardial-infarction
#7
Maozhou Tian, Lingmin Zhu, Hongyang Lin, Qiaoyan Lin, Peng Huang, Xiao Yu, Yanyan Jing
High thrombus burden, subsequent distal embolization, and myocardial no-reflow remain a large obstacle that may negate the benefits of urgent coronary revascularization in patients with ST-segment elevation myocardial infarction (STEMI). However, the biological function and clinical association of Hsp-27 with thrombus burden and clinical outcomes in patients with STEMI is not clear. Consecutive patients (n = 146) having STEMI undergoing primary percutaneous coronary intervention (pPCI) within 12 hours from the onset of symptoms were enrolled in this prospective study in the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shangdong, P...
May 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28554990/the-role-of-scube1-in-the-pathogenesis-of-no-reflow-phenomenon-presenting-with-st-segment-elevation-myocardial-infarction
#8
Hasan Ata Bolayır, Hakan Güneş, Tarık Kıvrak, Ömer Şahin, Dursun Akaslan, Recep Kurt, Aslı Bolayır, Oya İmadoğlu
OBJECTIVE: SCUBE1 [signal peptide-CUB (complement C1r/C1 s)-EGF (epidermal growth factor)-like domain-containing protein 1] might function as a novel platelet-endothelial adhesion molecule and play pathological roles in cardiovascular biology. Acute myocardial infarction is one of the most common causes of death in modern society. The concept of "no reflow" (NR) refers to a state of myocardial tissue hypoperfusion in the presence of a patent epicardial coronary artery. The main mechanisms of this phenomenon are thought to be high platelet activity and much thrombus burden...
May 24, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28514327/postoperative-assessment-of-myocardial-function-and-microcirculation-in-patients-with-acute-coronary-syndrome-by-myocardial-contrast-echocardiography
#9
Li Jiang, Hong Yao, Zhao-Guang Liang
BACKGROUND Postoperative myocardial function and microcirculation of acute coronary syndrome (ACS) was assessed by myocardial contrast echocardiography (MCE). MATERIAL AND METHODS Eighty-nine ACS patients treated with percutaneous coronary intervention (PCI) were detected by MCE and two-dimensional ultrasonography before and a month later after PCI respectively. Their myocardial perfusion was evaluated by myocardial contrast score (MSC) and contrast score index (CSI); cross-sectional area of microvessel (A), average myocardial microvascular impairment (β), and myocardial blood flow (MBF) were analyzed by cardiac ultrasound quantitative analysis (CUSQ), and fractional flow reserve (FFR) change was observed...
May 17, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28457096/long-term-outcomes-of-mguard-stent-deployment-in-saphenous-vein-grafts-and-native-coronary-arteries-a-single-center-experience
#10
Hana Vaknin-Assa, Abid Assali, Eli I Lev, Gabriel Greenberg, Katia Orvin, Orna Valzer, Gideon Paul, Amos Levi, Ran Kornowski
BACKGROUND: The MGuard™ stent (InspireMD, Tel Aviv, Israel) is a bare metal mesh-covered stent, developed to prevent no-reflow phenomenon during percutaneous coronary intervention (PCI) of saphenous vein grafts (SVG) and acute myocardial infarction (MI), both associated with significant atherothrombotic lesions. OBJECTIVES: To report on local experience with patients treated with the MGuard stent until follow-up at 1 year. METHODS: We followed 163 consecutive patients who underwent MGuard stent deployment during the period 2009 to 2014 in a large tertiary cardiac center in central Israel...
March 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28456697/impact-of-plaque-rupture-detected-by-optical-coherence-tomography-on-transmural-extent-of-infarction-after-successful-stenting-in-st-segment-elevation-acute-myocardial-infarction
#11
Keisuke Satogami, Yasushi Ino, Takashi Kubo, Takashi Tanimoto, Makoto Orii, Yoshiki Matsuo, Shingo Ota, Tomoyuki Yamaguchi, Yasutsugu Shiono, Kunihiro Shimamura, Yosuke Katayama, Hiroshi Aoki, Tsuyoshi Nishiguchi, Yuichi Ozaki, Takashi Yamano, Takeyoshi Kameyama, Akio Kuroi, Hironori Kitabata, Atsushi Tanaka, Takeshi Hozumi, Takashi Akasaka
OBJECTIVES: The aim of the present study was to investigate the association between plaque rupture (PR) assessed by optical coherence tomography (OCT), and the transmural extent of infarction (TEI) assessed by contrast-enhanced cardiac magnetic resonance imaging (CE-CMR) in ST-segment elevation myocardial infarction (STEMI) patients after primary percutaneous coronary intervention (PCI). BACKGROUND: PR is associated with larger infarct size as assessed by cardiac enzymes in STEMI patients...
May 22, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28427736/interactions-between-reciprocal-st-segment-downsloping-during-st-elevated-myocardial-infarction-and-global-cardiac-perfusion-and-functional-abnormalities
#12
Riccardo Liga, Enrico Orsini, Paolo Caravelli, Marco De Carlo, Anna Sonia Petronio, Mario Marzilli
Reciprocal ST-segment downsloping on electrocardiogram is a frequent finding during ST-elevated myocardial infarction (STEMI), but its etiology is still disputed. We sought to evaluate the relation between reciprocal ST-segment downsloping during STEMI and major cardiac perfusion and functional parameters. One hundred eighty-five patients with STEMI underwent emergency coronary angiography. The presence of reciprocal ST-segment downsloping was assessed. At coronary angiography, the corrected TIMI frame count (cTFC) was computed both on culprit and remote vessels and the occurrence of "no/slow reflow" phenomenon after percutaneous coronary intervention (PCI) identified...
March 29, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28400037/predictors-of-no-reflow-during-primary-angioplasty-for-acute-myocardial-infarction-from-medical-college-hospital-trivandrum
#13
Padmajan Sabin, Alummoottil George Koshy, Prabha Nini Gupta, Pattu Valappil Sanjai, Kunjukrishanpilla Sivaprasad, Praveen Velappan, Radhakrishnan Vellikat Velayudhan
BACKGROUND: Primary angioplasty (PCI) for acute myocardial infarction is associated with no-reflow phenomenon, in about 5-25% of cases. Here we analysed the factors predicting no reflow . METHODS: This was a case control study of consecutive patients with acute myocardial infarction who underwent Primary PCI from August 2014 to February 2015. RESULTS: Of 181 patients who underwent primary PCI, 47 (25.9%) showed an angiographic no-reflow phenomenon...
April 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28399648/the-highly-selective-caspase-1-inhibitor-vx-765-provides-additive-protection-against-myocardial-infarction-in-rat-hearts-when-combined-with-a-platelet-inhibitor
#14
Xi-Ming Yang, James M Downey, Michael V Cohen, Nicole A Housley, Diego F Alvarez, Jonathon P Audia
Use of ischemic postconditioning and other related cardioprotective interventions to treat patients with acute myocardial infarction (AMI) has failed to improve outcomes in clinical trials. Because P2Y12 inhibitors are themselves postconditioning mimetics, it has been postulated that the loading dose of platelet inhibitors routinely given to patients treated for AMI masks the anti-infarct effect of other intended cardioprotective interventions. To further improve outcomes of patients with AMI, an intervention must be able to provide additive protection in the presence of a P2Y12 platelet inhibitor...
January 1, 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28370496/role-of-deferred-stenting-in-patients-with-st-elevation-myocardial-infarction-treated-with-primary-percutaneous-coronary-intervention-a-systematic-review-and-meta-analysis
#15
Giovanni Luigi De Maria, Mohammad Alkhalil, Evangelos K Oikonomou, Mathias Wolfrum, Robin P Choudhury, Adrian P Banning
OBJECTIVES: We conducted a meta-analysis of studies comparing deferred stenting strategy versus the conventional approach with immediate stenting in patients with ST elevation myocardial infarction. BACKGROUND: Deferring stent after mechanical flow restoration has been proposed as a strategy to reduce the risk of "no reflow" in patients with STEMI undergoing primary percutaneous coronary intervention (pPCI). Conflicting evidence is available currently, especially after the recent publication of three randomized clinical trials...
March 28, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28357071/prostaglandin-e2-reduces-swine-myocardial-ischemia-reperfusion-injury-via-increased-endothelial-nitric-oxide-synthase-and-vascular-endothelial-growth-factor-expression-levels
#16
Ying Zhou, Peng Yang, Aili Li, Xiaojun Ye, Shiyan Ren, Xianlun Li
Prostaglandin E2 (PGE2) has been demonstrated to attenuate cardiac ischemia-reperfusion (I/R) injury. However, the underlying mechanism of PGE2 in cardiac I/R injury remains unknown. Upregulated expression levels of vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (eNOS) were reported in acute myocardial infarction (AMI), and were demonstrated to diminish I/R injury. In the current study the involvement of VEGF and eNOS in the myocardial protective effect of PGE2 were investigated in a catheter-based porcine model of AMI...
February 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28315564/clinical-risk-scores-predict-procedural-complications-of-primary-percutaneous-coronary-intervention
#17
László Hadadi, Razvan Constantin Şerban, Alina Scridon, Ioana Şuş, Éva Katalin Lakatos, Zoltán Demjén, Dan Dobreanu
OBJECTIVE: The predictive value of five risk score models containing clinical (PAMI-PMS, GRACE-GRS, and modified ACEF-ACEFm-scores), angiographic SYNTAX score (SXS) and combined Clinical SYNTAX score (CSS) variables were evaluated for the incidence of three procedural complications of primary percutaneous coronary intervention (pPCI): iatrogenic coronary artery dissection, angiographically visible distal embolization and angiographic no-reflow phenomenon. METHODS: The mentioned scores and the incidence of procedural complications were retrospectively analyzed in 399 consecutive patients with acute ST-elevation myocardial infarction who underwent pPCI...
March 9, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28286839/early-vs-late-coronary-angiography-and-intervention-following-thrombolytic-therapy-a-cohort-study
#18
Bahareh Feizi, Shahram Taghdisi, Jalil Etemadi, Amir Hossein Feizi, Setareh Asgarzadeh, Sepideh Kamal
INTRODUCTION: The precise time of using percutaneous coronary intervention (PCI) after fibrinolytic therapy for maximum efficiency and minimum side effects is still undetermined. Therefore, the present study was designed to compare the outcome of myocardial infarction (MI) patients who underwent surgical intervention (angiography and PCI) within 48 hours of thrombolytic therapy or after that. METHODS: The present study is a prospective cohort study aiming to compare the occurrence of no-reflow phenomenon, unstable angina, bleeding during intervention, and one month major adverse cardiac outcomes (recurrent MI, need for repeating surgical intervention, and mortality) between MI patents undergoing surgical intervention within the first 48 hours of or after 48 hours of thrombolytic therapy...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28275202/low-volume-resuscitation-for-hemorrhagic-shock-understanding-the-mechanism-of-peg-20k
#19
Valerie Plant, Dan W Parrish, Ashley Limkemann, Paula Ferrada, Michel Aboutanos, Martin J Mangino
Hemorrhagic shock leads to cell and tissue swelling and no reflow from compressed capillaries. Cell impermeants, including polyethylene glycol-20,000 (PEG-20k), reverse ischemia-induced cell swelling, extend low-volume resuscitation (LVR) time after shock, and increase tolerance to the low-volume state. The purpose of this study was to explore the mechanisms of action of PEG-20k containing LVR solutions. We hypothesized that PEG-20k acts as both an oncotic agent and an impermeant in the microcirculation, which moves water out of the space and into the capillaries to affect peripheral capillary filling and enhanced perfusion during the low-volume state...
May 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28275065/deferred-versus-immediate-stenting-in-patients-with-st-segment-elevation-myocardial-infarction-a-systematic-review-and-meta-analysis
#20
REVIEW
Jianzhong Qiao, Lingxin Pan, Bin Zhang, Jie Wang, Yongyan Zhao, Ru Yang, Huiling Du, Jie Jiang, Conghai Jin, Enlai Xiong
BACKGROUND: A number of studies have evaluated the efficacy of deferred stenting vs immediate stenting in patients with ST-segment elevation myocardial infarction, but the findings were not consistent across these studies. This meta-analysis aims to assess optimal treatment strategies in patient with ST-segment elevation myocardial infarction. METHODS AND RESULTS: We searched the PubMed, EMBASE, and the Cochrane Library for studies that assessed deferred vs immediate stenting in patients with ST-segment elevation myocardial infarction...
March 8, 2017: Journal of the American Heart Association
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