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https://www.readbyqxmd.com/read/28828881/correlates-and-prognostic-impact-of-new-onset-heart-failure-after-st-segment-elevation-myocardial-infarction-treated-with-primary-percutaneous-coronary-intervention-insights-from-the-infuse-ami-trial
#1
Gennaro Giustino, Björn Redfors, Sorin J Brener, Ajay J Kirtane, Philippe Généreux, Akiko Maehara, Dariusz Dudek, Thomas Neunteufl, D Christopher Metzger, Aaron Crowley, Roxana Mehran, C Michael Gibson, Gregg W Stone
BACKGROUND: The determinants and significance of early (30-day) heart failure symptoms after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction (STEMI) remain unclear. We investigated the clinical and imaging correlates of early post-discharge heart failure in patients with STEMI, and evaluated its impact on clinical outcomes. METHODS: Patients from the INFUSE-AMI trial were categorized according to New York Heart Association (NYHA) functional classification at their 30-day visit (NYHA class ≥2 versus 1)...
August 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28800739/sources-of-variability-in-quantification-of-cardiovascular-magnetic-resonance-infarct-size-reproducibility-among-three-core-laboratories
#2
Igor Klem, Einar Heiberg, Lowie Van Assche, Michele A Parker, Han W Kim, John D Grizzard, Håkan Arheden, Raymond J Kim
BACKGROUND: Acute myocardial infarct (AMI) size depicted by late gadolinium enhancement cardiovascular magnetic resonance (CMR) is increasingly used as an efficacy endpoint in randomized trials comparing AMI therapies. Infarct size is quantified using manual planimetry (MANUAL), visual scoring (VISUAL), or automated techniques using signal-intensity thresholding (AUTO). Although AUTO is considered the most reproducible, prior studies did not account for the subjective determination of endocardial/epicardial borders, which all methods require...
August 11, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28799712/deferred-or-immediate-stent-implantation-for-primary-percutaneous-coronary-intervention-a-meta-analysis-of-randomized-trials
#3
Ahmed N Mahmoud, Marwan Saad, Akram Y Elgendy, Amgad Mentias, Islam Y Elgendy
OBJECTIVES: To perform a meta-analysis of randomized trials comparing a deferred versus immediate stenting strategy for primary percutaneous coronary intervention (PCI). BACKGROUND: Deferred stent implantation has emerged as a potential strategy aiming to reduce the thrombus burden and improve micro-vascular reperfusion during primary PCI. METHODS: Electronic databases were searched for randomized trials that compared a deferred stent implantation versus immediate stent implantation strategy in patients undergoing primary PCI...
August 11, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28797412/optical-coherence-tomography-characterization-of-coronary-lithoplasty-for-treatment-of-calcified-lesions-first-description
#4
Ziad A Ali, Todd J Brinton, Jonathan M Hill, Akiko Maehara, Mitsuaki Matsumura, Keyvan Karimi Galougahi, Uday Illindala, Matthias Götberg, Robert Whitbourn, Nicolas Van Mieghem, Ian T Meredith, Carlo Di Mario, Jean Fajadet
OBJECTIVES: This study sought to determine the mechanistic effects of a novel balloon-based lithoplasty system on heavily calcified coronary lesions and subsequent stent placement using optical coherence tomography (OCT). BACKGROUND: The Shockwave Coronary Rx Lithoplasty System (Shockwave Medical, Fremont, California) delivers localized, lithotripsy-enhanced disruption of calcium within the target lesion (i.e., lithoplasty) for vessel preparation before stent implantation...
August 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28748958/new-and-revisited-approaches-to-preserving-the-reperfused-myocardium
#5
REVIEW
Robert A Kloner, David A Brown, Marie Csete, Wangde Dai, James M Downey, Roberta A Gottlieb, Sharon L Hale, Jianru Shi
Early coronary artery reperfusion improves outcomes for patients with ST-segment elevation myocardial infarction (STEMI), but morbidity and mortality after STEMI remain unacceptably high. The primary deficits seen in these patients include inadequate pump function, owing to rapid infarction of muscle in the first few hours of treatment, and adverse remodelling of the heart in the months that follow. Given that attempts to further reduce myocardial infarct size beyond early reperfusion in clinical trials have so far been disappointing, effective therapies are still needed to protect the reperfused myocardium...
July 27, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28722196/safety-of-orbital-atherectomy-in-patients-with-left-ventricular-systolic-dysfunction
#6
Evan Shlofmitz, Perwaiz Meraj, Rajiv Jauhar, Sanjum S Sethi, Richard A Shlofmitz, Michael S Lee
OBJECTIVES: We evaluated the angiographic and clinical outcomes in patients with severely calcified lesions and systolic dysfunction who underwent orbital atherectomy (OA). We hypothesized that OA would provide similar outcomes in patients with systolic dysfunction compared with patients with preserved systolic function. BACKGROUND: Systolic dysfunction is associated with an increased risk of adverse clinical events after percutaneous coronary intervention (PCI)...
July 19, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28683935/temporal-trends-complications-and-predictors-of-outcomes-among-nonagenarians-undergoing-percutaneous%C3%A2-coronary-intervention-insights-from-the-veterans-affairs-clinical-assessment-reporting-and-tracking-program
#7
Abhishek C Sawant, Kevin Josey, Mary E Plomondon, Thomas M Maddox, Aishwarya Bhardwaj, Vasvi Singh, Bharath Rajagopalan, Zaid Said, Deepak L Bhatt, John Corbelli
OBJECTIVES: The aim of this study was to determine temporal trends, in-laboratory complications, mortality, and predictors of mortality among nonagenarians undergoing percutaneous coronary intervention (PCI). BACKGROUND: Nonagenarians (patients 90 years of age or older) undergoing PCI are often underrepresented in clinical trials, and their management remains challenging and controversial. METHODS: All veterans undergoing PCI with data recorded in the Veterans Affairs Clinical Assessment, Reporting, and Tracking program from 2005 to 2014 were evaluated...
July 10, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28667102/adiponectin-improves-coronary-no-reflow-injury-by-protecting-the-endothelium-in-rats-with-type-2-diabetes-mellitus
#8
Xue Han, Ye Wu, Xin Liu, Lu Ma, Tingting Lv, Qi Sun, Wenli Xu, Suli Zhang, Ke Wang, Wen Wang, Xinliang Ma, Huirong Liu
To determine the effect of adiponectin (APN) on the coronary no-reflow (NR) injury in rats with Type 2 diabetes mellitus (T2DM), 80 male Sprague-Dawley rats were fed with a high-sugar-high-fat diet to build a T2DM model. Rats received vehicle or APN in the last week and then were subjected to myocardial ischemia reperfusion (MI/R) injury. Endothelium-dependent vasorelaxation of the thoracic aorta was significantly decreased and serum levels of endothelin-1 (ET-1), intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were noticably increased in T2DM rats compared with rats without T2DM...
August 31, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28664479/comparison-of-syntax-score-and-syntax-score-ii-to-predict-no-reflow-phenomenon-in-patients-with-st-segment-elevation-myocardial-infarction
#9
Mahmut Yesin, Metin Çağdaş, Macit Kalçık, Mahmut Uluganyan, Süleyman Çağan Efe, İbrahim Rencüzoğulları, Yavuz Karabağ, Mustafa Ozan Gürsoy, Süleyman Karakoyun
Even though the relationship between syntax score (SS) and coronary no-reflow phenomenon has been studied, the relation between SS and syntax score II (SS II) in patients with no-reflow phenomenon is unknown. We aimed to define the relationship between coronary no-reflow phenomenon and SS II as compared with SS. This study enrolled 193 patients undergoing primary percutaneous coronary intervention for ST elevation myocardial infarction in whom 42 patients developed the no-reflow phenomenon. SS and SS II were calculated in all patients...
June 29, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28633762/usefulness-of-mean-platelet-volume-to-lymphocyte-ratio-for-predicting-angiographic-no-reflow-and-short-term-prognosis-after-primary-percutaneous-coronary-intervention-in-patients-with-st-segment-elevation-myocardial-infarction
#10
Alparslan Kurtul, Sadik Kadri Acikgoz
Primary percutaneous coronary intervention (pPCI) is associated with improved prognosis in patients with ST-segment elevation myocardial infarction (STEMI). However, no-reflow phenomenon limits the benefit of revascularization and predicts adverse outcomes. The specific mechanism for its occurrence is still not entirely clear, and it is believed at present that platelet activation and inflammation play a pivotal role in developing no-reflow. Both increased mean platelet volume (MPV), which is a platelet activation marker, and lymphopenia, which is an inflammation marker, have been linked to adverse events and poor prognosis after STEMI...
August 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28623012/p-wave-peak-time-a-novel-electrocardiographic-parameter-in-the-assessment-of-coronary-no-reflow
#11
Metin Çağdaş, Süleyman Karakoyun, İbrahim Rencüzoğulları, Yavuz Karabağ, Mahmut Yesin, Mustafa Ozan Gürsoy, İnanç Artaç, Doğan İliş, Süleyman Çağan Efe, Onur Taşar, Gürkan Karaca
OBJECTIVES: Coronary no-reflow (NR) following primary percutaneous coronary intervention (pPCI) is associated with worsened prognosis in patients with ST segment elevation myocardial infarction (STEMI). Despite rapid developments in cardiovascular area; there are limited data regarding prediction of NR before pPCI. P wave duration and dispersion (PWD, PWDIS, respectively) have been studied in STEMI patients and found to be associated with reperfusion success; however none of them has been found to predict NR before PCI...
June 8, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28617765/cardioprotective-effects-of-nicorandil-on-coronary-heart-disease-patients-undergoing-elective-percutaneous-coronary-intervention
#12
Zhihua Pang, Wei Zhao, Zhuhua Yao
BACKGROUND Nicorandil is a nicotinamide ester commonly prescribed for treatment of patients with coronary heart disease (CHD). In the present study, we aimed to explore the cardioprotective effects of nicorandil on CHD patients undergoing elective percutaneous coronary intervention (PCI). MATERIAL AND METHODS One hundred patients with CHD undergoing PCI were randomly divided into a control group (n=48) and a nicorandil group (n=52). Patients in the control group received traditional therapy, and while patients in the nicorandil group received nicorandil before PCI in addition to the traditional therapy...
June 15, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28613283/risk-factors-for-no-reflow-phenomenon-after-percutaneous-coronary-intervention-in-patients-with-acute-coronary-syndrome
#13
Tian Liang, Min Liu, Chengyu Wu, Qing Zhang, Lei Lu, Zhongliang Wang
BACKGROUND: To explore risk factors for no-reflow phenomenon after percutaneous coronary intervention in patients with acute coronary syndrome. METHODS: A total of 733 acute myocardial infarction patients with persistent ischemic chest pain within 12 or 12-24 hours after onset received emergency percutaneous coronary intervention. Patients were divided into a normal reflow group and a no-reflow group, according to TIMI grading and myocardial blush grading after percutaneous coronary intervention...
May 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28592591/identification-of-high-risk-patients-after-st-segment-elevation-myocardial-infarction-comparison-between-angiographic-and-magnetic-resonance-parameters
#14
COMPARATIVE STUDY
Alessandro Durante, Alessandra Laricchia, Giulia Benedetti, Antonio Esposito, Alberto Margonato, Ornella Rimoldi, Francesco De Cobelli, Antonio Colombo, Paolo G Camici
BACKGROUND: The incidence of angiographic no reflow (NR) and microvascular obstruction (MVO) at cardiac magnetic resonance is significantly different. The aim of this study was to investigate the occurrence of NR and MVO in a cohort of consecutive patients with ST-segment-elevation myocardial infarction treated with primary percutaneous coronary interventions. METHODS AND RESULTS: In this prospective study, 88 consecutive ST-segment-elevation myocardial infarction patients were enrolled within 12 hours from symptoms onset...
June 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28583820/impact-of-platelet-inhibition-level-on-subsequent-no-reflow-in-patients-undergoing-primary-percutaneous-coronary-intervention-for-st-segment-elevation-myocardial-infarction
#15
Omar Aitmokhtar, Franck Paganelli, Saida Benamara, Adel Azaza, Laurent Bonello, Ouafa Hamza, Saber Seddiki, Tayeb Benathmane, Mourad Saidane, Ahmed Bouzid, Maamar Kara, Arezki Sik, Abdelmalek Azzouz, Faiza Harbi, Jean-Jacques Monsuez, Salim Benkhedda
BACKGROUND: High P2Y12 platelet reactivity (PR) level after primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI) affects prognosis and may induce the no-reflow phenomenon. AIM: To investigate the role of PR in the genesis of microvascular obstruction. METHODS: Patients with STEMI undergoing PPCI within 12hours of symptoms onset were included prospectively. All patients received a 600mg clopidogrel-loading dose before PPCI and 250mg aspirin...
June 2, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28562325/hsp-27-levels-and-thrombus-burden-relate-to-clinical-outcomes-in-patients-with-st-segment-elevation-myocardial-infarction
#16
Maozhou Tian, Lingmin Zhu, Hongyang Lin, Qiaoyan Lin, Peng Huang, Xiao Yu, Yanyan Jing
High thrombus burden, subsequent distal embolization, and myocardial no-reflow remain a large obstacle that may negate the benefits of urgent coronary revascularization in patients with ST-segment elevation myocardial infarction (STEMI). However, the biological function and clinical association of Hsp-27 with thrombus burden and clinical outcomes in patients with STEMI is not clear. Consecutive patients (n = 146) having STEMI undergoing primary percutaneous coronary intervention (pPCI) within 12 hours from the onset of symptoms were enrolled in this prospective study in the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shangdong, P...
May 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28554990/the-role-of-scube1-in-the-pathogenesis-of-no-reflow-phenomenon-presenting-with-st-segment-elevation-myocardial-infarction
#17
Hasan Ata Bolayır, Hakan Güneş, Tarık Kıvrak, Ömer Şahin, Dursun Akaslan, Recep Kurt, Aslı Bolayır, Oya İmadoğlu
OBJECTIVE: SCUBE1 [signal peptide-CUB (complement C1r/C1 s)-EGF (epidermal growth factor)-like domain-containing protein 1] might function as a novel platelet-endothelial adhesion molecule and play pathological roles in cardiovascular biology. Acute myocardial infarction is one of the most common causes of death in modern society. The concept of "no reflow" (NR) refers to a state of myocardial tissue hypoperfusion in the presence of a patent epicardial coronary artery. The main mechanisms of this phenomenon are thought to be high platelet activity and much thrombus burden...
May 24, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28514327/postoperative-assessment-of-myocardial-function-and-microcirculation-in-patients-with-acute-coronary-syndrome-by-myocardial-contrast-echocardiography
#18
Li Jiang, Hong Yao, Zhao-Guang Liang
BACKGROUND Postoperative myocardial function and microcirculation of acute coronary syndrome (ACS) was assessed by myocardial contrast echocardiography (MCE). MATERIAL AND METHODS Eighty-nine ACS patients treated with percutaneous coronary intervention (PCI) were detected by MCE and two-dimensional ultrasonography before and a month later after PCI respectively. Their myocardial perfusion was evaluated by myocardial contrast score (MSC) and contrast score index (CSI); cross-sectional area of microvessel (A), average myocardial microvascular impairment (β), and myocardial blood flow (MBF) were analyzed by cardiac ultrasound quantitative analysis (CUSQ), and fractional flow reserve (FFR) change was observed...
May 17, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28457096/long-term-outcomes-of-mguard-stent-deployment-in-saphenous-vein-grafts-and-native-coronary-arteries-a-single-center-experience
#19
Hana Vaknin-Assa, Abid Assali, Eli I Lev, Gabriel Greenberg, Katia Orvin, Orna Valzer, Gideon Paul, Amos Levi, Ran Kornowski
BACKGROUND: The MGuard™ stent (InspireMD, Tel Aviv, Israel) is a bare metal mesh-covered stent, developed to prevent no-reflow phenomenon during percutaneous coronary intervention (PCI) of saphenous vein grafts (SVG) and acute myocardial infarction (MI), both associated with significant atherothrombotic lesions. OBJECTIVES: To report on local experience with patients treated with the MGuard stent until follow-up at 1 year. METHODS: We followed 163 consecutive patients who underwent MGuard stent deployment during the period 2009 to 2014 in a large tertiary cardiac center in central Israel...
March 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28456697/impact-of-plaque-rupture-detected-by-optical-coherence-tomography-on-transmural-extent-of-infarction-after-successful-stenting-in-st-segment-elevation-acute-myocardial-infarction
#20
Keisuke Satogami, Yasushi Ino, Takashi Kubo, Takashi Tanimoto, Makoto Orii, Yoshiki Matsuo, Shingo Ota, Tomoyuki Yamaguchi, Yasutsugu Shiono, Kunihiro Shimamura, Yosuke Katayama, Hiroshi Aoki, Tsuyoshi Nishiguchi, Yuichi Ozaki, Takashi Yamano, Takeyoshi Kameyama, Akio Kuroi, Hironori Kitabata, Atsushi Tanaka, Takeshi Hozumi, Takashi Akasaka
OBJECTIVES: The aim of the present study was to investigate the association between plaque rupture (PR) assessed by optical coherence tomography (OCT), and the transmural extent of infarction (TEI) assessed by contrast-enhanced cardiac magnetic resonance imaging (CE-CMR) in ST-segment elevation myocardial infarction (STEMI) patients after primary percutaneous coronary intervention (PCI). BACKGROUND: PR is associated with larger infarct size as assessed by cardiac enzymes in STEMI patients...
May 22, 2017: JACC. Cardiovascular Interventions
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