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https://www.readbyqxmd.com/read/27891513/clinic-predictive-factors-for-insufficient-myocardial-reperfusion-in-st-segment-elevation-myocardial-infarction-patients-treated-with-selective-aspiration-thrombectomy-during-primary-percutaneous-coronary-intervention
#1
Jinfan Tian, Yue Liu, Xiantao Song, Min Zhang, Feng Xu, Fei Yuan, Shuzheng Lyu
Background. Insufficient data are available on the potential benefit of selective aspiration and clinical predictors for no-reflow in STEMI patients undergoing primary percutaneous coronary intervention (PPCI) adjunct with aspiration thrombectomy. Objective. The aim of our study was to investigate clinical predictors for insufficient reperfusion in patients with high thrombus burden treated with PPCI and manual aspiration thrombectomy. Methods. From January 2011 till December 2015, 277 STEMI patients undergoing manual aspiration thrombectomy and PPCI were selected and 202 patients with a Thrombolysis in Myocardial Infarction (TIMI) thrombus grade 4~5 were eventually involved in our study...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27869849/optical-coherence-tomography-imaging-of-capillary-reperfusion-after-ischemic-stroke
#2
Jonghwan Lee, Yasemin Gursoy-Ozdemir, Buyin Fu, David A Boas, Turgay Dalkara
Although progress has been made for recanalization therapies after ischemic stroke, post-treatment imaging studies show that tissue reperfusion cannot be attained despite satisfactory recanalization in a significant percentage of patients. Hence, investigation of microcirculatory changes in both surface and deep cortical levels after ischemia reperfusion is important for understanding the post-stroke blood flow dynamics. In this study, we applied optical coherence tomography (OCT) imaging of cerebral blood flow for the quantification of the microcirculatory changes...
November 20, 2016: Applied Optics
https://www.readbyqxmd.com/read/27842548/infarct-size-following-complete-revascularization-in-patients-presenting-with-stemi-a-comparison-of-immediate-and-staged-in-hospital-non-infarct-related-artery-pci-subgroups-in-the-cvlprit-study
#3
Jamal N Khan, Sheraz A Nazir, John P Greenwood, Miles Dalby, Nick Curzen, Simon Hetherington, Damian J Kelly, Daniel Blackman, Arne Ring, Charles Peebles, Joyce Wong, Thiagarajah Sasikaran, Marcus Flather, Howard Swanton, Anthony H Gershlick, Gerry P McCann
BACKGROUND: The CvLPRIT study showed a trend for improved clinical outcomes in the complete revascularisation (CR) group in those treated with an immediate, as opposed to staged in-hospital approach in patients with multivessel coronary disease undergoing primary percutaneous intervention (PPCI). We aimed to assess infarct size and left ventricular function in patients undergoing immediate compared with staged CR for multivessel disease at PPCI. METHODS: The Cardiovascular Magnetic Resonance (CMR) substudy of CvLPRIT was a multicentre, prospective, randomized, open label, blinded endpoint trial in PPCI patients with multivessel disease...
November 9, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27836132/gender-differences-in-associations-between-intraprocedural-thrombotic-events-during-percutaneous-coronary-intervention-and-adverse-outcomes
#4
Mikkel M Schoos, Roxana Mehran, George D Dangas, Jennifer Yu, Usman Baber, Peter Clemmensen, Frederick Feit, Bernard J Gersh, Giulio Guagliumi, E Magnus Ohman, Stuart J Pocock, Bernhard Witzenbichler, Gregg W Stone
Women are frequently reported to have increased morbidity after presentation with acute coronary syndromes and myocardial infarction; however, whether a greater thrombotic tendency contributes to gender differences in clinical outcomes of urgent percutaneous coronary intervention is unknown. Intraprocedural Thrombotic Events (IPTEs) are defined as new or increasing thrombus, abrupt vessel closure, no reflow or slow reflow, or distal embolization at any time during percutaneous coronary intervention. IPTEs were evaluated in this pooled analysis of 6,591 patients with stent implantation and blinded quantitative coronary angiography (QCA) analysis, from the ACUITY and HORIZONS-AMI trials...
October 11, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27801655/gender-based-differences-in-outcomes-after-orbital-atherectomy-for-the-treatment-of-de-novo-severely-calcified-coronary-lesions
#5
Michael S Lee, Evan Shlofmitz, Pejman Mansourian, Sanjum Sethi, Richard A Shlofmitz
OBJECTIVES: We evaluated the relationship between gender and angiographic and clinical outcomes in patients with severely calcified lesions who underwent orbital atherectomy. BACKGROUND: Female gender is associated with increased risk of adverse clinical events after percutaneous coronary intervention (PCI). Severe coronary artery calcification increases the complexity of PCI and increases the risk of adverse cardiac events. Orbital atherectomy is effective in plaque modification, which facilitates stent delivery and expansion...
November 2016: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/27775781/clinical-significance-of-dynamic-changes-in-hs-crp-and-adamts13-levels-in-the-blood-serum-of-patients-with-no-reflow-after-pci-operation
#6
W B Liu, Z-P Zou, H-P Jiang, Q Li, F-M Guo, Z Wang, Z-S Bi
OBJECTIVE: To evaluate the clinical significance dynamic changes in hs-CRP and ADAMTS13 levels in patients with no-reflow after PCI operation. PATIENTS AND METHODS: 156 patients with STEMI single-vessel were enrolled in this study. Patients were divided into the reflow and the no-reflow groups. ADAMTS13 and hs-CRP levels were compared between the two groups. RESULTS: ADAMTS13 and hs-CRP levels in the no-reflow group were significantly lower than those in the reflow group after PCI operation...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27770057/plasma-apelin-12-levels-may-predict-in-hospital-major-adverse-cardiac-events-in-st-elevation-myocardial-infarction-and-the-relationship-between-apelin-12-and-the-neutrophil-lymphocyte-ratio-in-patients-undergoing-primary-coronary-intervention
#7
Mustafa Topuz, Fahrettin Oz, Oguz Akkus, Omer Sen, Ayse Nur Topuz, Atilla Bulut, Suleyman Ozbicer, Sefa Okar, Mevlut Koc, Mustafa Gur
OBJECTIVE: We aimed to investigate the compliance of plasma apelin-12 levels to show angiographic properties and hospital MACE in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). MATERIAL AND METHODS: The association of apelin-12 levels with the N/L ratio on admission was assessed in 170 consecutive patients with primary STEMI undergoing primary PCI. All patient SYNTAX scores and thrombolysis in myocardial infarction (TIMI) flow grades were also assessed...
October 20, 2016: Perfusion
https://www.readbyqxmd.com/read/27747447/cardioprotective-effects-of-mitochondria-targeted-peptide-sbt-20-in-two-different-models-of-rat-ischemia-reperfusion
#8
Wangde Dai, Elissa Cheung, Rick J Alleman, Justin B Perry, Mitchell E Allen, David A Brown, Robert A Kloner
PURPOSE: Dysfunctional mitochondria are considered to be the major source of intracellular reactive oxygen species and play a central role in the pathophysiology of myocardial ischemia/reperfusion. This study sought to determine effects of mitochondria-targeted cytoprotective peptide SBT-20 on myocardial infarct size in two different models of ischemia/reperfusion. METHODS: For in vivo studies, anesthetized Sprague Dawley rats were subjected to 30 min of coronary artery occlusion followed by 3 h of reperfusion...
October 17, 2016: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/27723055/response-to-the-letter-regarding-the-article-predictive-value-of-admission-red-cell-distribution-width-platelet-ratio-for-no-reflow-phenomenon-in-acute-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention
#9
https://www.readbyqxmd.com/read/27712735/does-residual-thrombus-after-aspiration%C3%A2-thrombectomy-affect-the%C3%A2-outcome-of-primary-pci-in-patients%C3%A2-with%C3%A2-st-segment-elevation-myocardial-infarction-an-optical-coherence-tomography-study
#10
Takumi Higuma, Tsunenari Soeda, Masahiro Yamada, Takashi Yokota, Hiroaki Yokoyama, Kei Izumiyama, Fumie Nishizaki, Yoshiyasu Minami, Lei Xing, Erika Yamamoto, Hang Lee, Ken Okumura, Ik-Kyung Jang
OBJECTIVES: The aim of this study was to evaluate if residual thrombus burden after aspiration thrombectomy affects the outcomes of primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction (STEMI). BACKGROUND: Recent studies failed to show clinical benefit of aspiration thrombectomy in STEMI patients. This might be due to insufficient removal of thrombus at the culprit lesion. METHODS: A total of 109 STEMI patients who underwent aspiration thrombectomy followed by stenting within 24 h from symptom onset were included...
October 10, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27692660/therapeutic-hypothermia-to-protect-the-heart-against-acute-myocardial-infarction
#11
Matthias Kohlhauer, Alain Berdeaux, Bijan Ghaleh, Renaud Tissier
The cardioprotective effect of therapeutic hypothermia (32-34°C) has been well demonstrated in animal models of acute myocardial infarction. Beyond infarct size reduction, this protection was associated with prevention of the no-reflow phenomenon and long-term improvement in terms of left ventricular remodelling and performance. However, all these events were observed when hypothermia was induced during the ischaemic episode, and most benefits virtually vanished after reperfusion. This is consistent with clinical findings showing a lack of benefit from hypothermia in patients presenting acute myocardial infarction in most trials...
September 28, 2016: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/27677883/exosomes-secreted-by-cardiosphere-derived-cells-reduce-scarring-attenuate-adverse-remodelling-and-improve-function-in-acute-and-chronic-porcine-myocardial-infarction
#12
Romain Gallet, James Dawkins, Jackelyn Valle, Eli Simsolo, Geoffrey de Couto, Ryan Middleton, Eleni Tseliou, Daniel Luthringer, Michelle Kreke, Rachel R Smith, Linda Marbán, Bijan Ghaleh, Eduardo Marbán
AIMS: Naturally secreted nanovesicles known as exosomes are required for the regenerative effects of cardiosphere-derived cells (CDCs), and exosomes mimic the benefits of CDCs in rodents. Nevertheless, exosomes have not been studied in a translationally realistic large-animal model. We sought to optimize delivery and assess the efficacy of CDC-secreted exosomes in pig models of acute (AMI) and convalescent myocardial infarction (CMI). METHODS AND RESULTS: In AMI, pigs received human CDC exosomes (or vehicle) by intracoronary (IC) or open-chest intramyocardial (IM) delivery 30 min after reperfusion...
September 27, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27650230/increased-platelet-leukocyte-aggregates-are-associated-with-myocardial-no-reflow-in-patients-with-st-elevation-myocardial-infarction
#13
Faxin Ren, Nan Mu, Xia Zhang, Jinxi Tan, Liudong Li, Chuanhuan Zhang, Mei Dong
OBJECTIVE: We aimed to investigate the association between platelet-leukocyte aggregates (PLA) levels on admission and the risk of myocardial no-reflow in patients with ST elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI). METHODS: A total of 83 patients with STEMI undergoing primary PCI were included in the current study. Platelet-leukocyte conjugates (PLA), including platelet-monocyte aggregates (PMA), platelet-neutrophil aggregates (PNA) and platelet-lymphocyte aggregates were studied by flow cytometry in peripheral venous blood...
September 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27644317/hspa12b-attenuated-acute-myocardial-ischemia-reperfusion-injury-via-maintaining-endothelial-integrity-in-a-pi3k-akt-mtor-dependent-mechanism
#14
Qiuyue Kong, Leyang Dai, Yana Wang, Xiaojin Zhang, Chuanfu Li, Surong Jiang, Yuehua Li, Zhengnian Ding, Li Liu
Endothelial damage is a critical mediator of myocardial ischemia/reperfusion (I/R) injury. HSPA12B is an endothelial-cell-specifically expressed heat shock protein. However, the roles of HSPA12B in acute myocardial I/R injury is unknown. Here we reported that myocardial I/R upregulated HSPA12B expression in ventricular tissues, and endothelial overexpression of HSPA12B in transgenic mice (Tg) limited infarct size, attenuated cardiac dysfunction and improved cardiomyocyte survival compared with their wild type littermates...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27643472/cardioprotective-effects-of-intracoronary-administration-of-4-chlorodiazepam-in-small-and-large-animal-models-of-ischemia-reperfusion
#15
Michalis Tsamatsoulis, Chris J Kapelios, Lambros Katsaros, Stella Vakrou, Vasilis Sousonis, Stefania Sventzouri, Nicholas Michelinakis, Despoina N Perrea, Maria Anastasiou-Nana, Konstantinos Malliaras
BACKGROUND: The Translocator Protein (TSPO) of the mitochondrial membrane has been recognized as a potential therapeutic target for mitigation of myocardial ischemia-reperfusion injury. Administration of 4-chlorodiazepam (4-CLD), a TSPO ligand, has been shown to confer acute cardioprotective effects in small animals; however, long-term studies and studies in clinically-relevant large animal models are lacking. In the present study we investigated a potential cardioprotective effect of intracoronary administration of 4-CLD in small and large animal models of ischemia-reperfusion...
September 10, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27638105/association-of-endothelial-dysfunction-and-no-reflow-during-primary-percutaneous-coronary-intervention-for-st-elevation-myocardial-infarction
#16
Yaniv Levi, Ayyaz Sultan, Mistre Alemayehu, Sabrina Wall, Shahar Lavi
BACKGROUND: Coronary no-reflow during primary percutaneous coronary intervention (PPCI) is a predictor of poorer cardiovascular outcome. Both endothelial dysfunction and no-reflow involves abnormal vascular function and hemostasis. Our aim was to assess the association between endothelial dysfunction and no reflow during primary PCI. METHODS: Thirty consecutive patients with ST elevation myocardial infarction (STEMI) and normal flow during primary PCI were compared to 19 consecutive patients who had no reflow...
September 3, 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/27636925/-primary-percutaneous-interventions-into-the-coronary-arteries-in-patients-with-diabetes-mellitus
#17
I S Bessonov, V A Kuznetsov, I P Zyryanov, S S Sapozhnikov, N A Musikhina, A G Rozhkov
AIM: to investigate the specific features and results of percutaneous interventions (PCI) into the coronary arteries in patients with acute ST-segment elevation myocardial infarction (MI) and diabetes mellitus (DM) in clinical practice. SUBJECTS AND METHODS: A study group consisted of 120 patients with a history of type 2 DM, who had undergone primary PCI in 2008 to 2013. A comparison group included 601 patients without a history of DM. RESULTS: Assessment of the results of hospital interventions revealed no differences between the study and comparison groups in mortality rates (4...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27603665/a-translational-study-of-a-new-therapeutic-approach-for-acute-myocardial-infarction-nanoparticle-mediated-delivery-of-pitavastatin-into-reperfused-myocardium-reduces-ischemia-reperfusion-injury-in-a-preclinical-porcine-model
#18
Kenzo Ichimura, Tetsuya Matoba, Kaku Nakano, Masaki Tokutome, Katsuya Honda, Jun-Ichiro Koga, Kensuke Egashira
BACKGROUND: There is an unmet need to develop an innovative cardioprotective modality for acute myocardial infarction, for which interventional reperfusion therapy is hampered by ischemia-reperfusion (IR) injury. We recently reported that bioabsorbable poly(lactic acid/glycolic acid) (PLGA) nanoparticle-mediated treatment with pitavastatin (pitavastatin-NP) exerts a cardioprotective effect in a rat IR injury model by activating the PI3K-Akt pathway and inhibiting inflammation. To obtain preclinical proof-of-concept evidence, in this study, we examined the effect of pitavastatin-NP on myocardial IR injury in conscious and anesthetized pig models...
2016: PloS One
https://www.readbyqxmd.com/read/27543480/no-reflow-phenomenon-in-percutaneous-coronary-interventions-in-st-segment-elevation-myocardial-infarction
#19
REVIEW
Sanjiv Gupta, Madan Mohan Gupta
Percutaneous coronary intervention (PCI) is effective in opening the infarct related artery and restoring thrombolysis in myocardial infarction flow 3 (TIMI-flow 3) in large majority of ST-elevation myocardial infarction (STEMI). However there remain a small but significant proportion of patients, who continue to manifest diminished myocardial reperfusion despite successful opening of the obstructed epicardial artery. This phenomenon is called no-reflow. Clinically it manifests with recurrence of chest pain and dyspnea and may progress to cardiogenic shock, cardiac arrest, serious arrhythmias and acute heart failure...
July 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27513233/the-utility-of-the-timi-risk-index-on-admission-for-predicting-angiographic-no-reflow-after-primary-percutaneous-coronary-intervention-in-patients-with-stemi
#20
Halit Acet, Faruk Ertaş, Mehmet Ata Akil, Mehmet Zihni Bilik, Mesut Aydin, Nihat Polat, Abdulkadir Yildiz
BACKGROUND/AIM: The thrombolysis in myocardial infarction (TIMI) risk score (TRS), and the TIMI risk index (TRI) have been reported in coronary artery disease patients. We investigated whether admission TRI is associated with no-reflow (NRF) in patients undergoing primary percutaneous coronary intervention (p-PCI). MATERIALS AND METHODS: ST-segment elevation myocardial infarction (STEMI) patients treated with p-PCI were included in the study. TRI was calculated on admission using specified variables...
2016: Turkish Journal of Medical Sciences
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