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Fecal transplant

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https://www.readbyqxmd.com/read/28239315/single-fecal-microbiota-transplantation-failed-to-change-intestinal-microbiota-and-had-limited-effectiveness-against-ulcerative-colitis-in-japanese-patients
#1
Shinta Mizuno, Kosaku Nanki, Katsuyoshi Matsuoka, Keiichiro Saigusa, Keiko Ono, Mari Arai, Shinya Sugimoto, Hiroki Kiyohara, Moeko Nakashima, Kozue Takeshita, Makoto Naganuma, Wataru Suda, Masahira Hattori, Takanori Kanai
BACKGROUND/AIMS: Recent developments in analytical techniques including next-generation sequencing have clarified the correlation between intestinal microbiota and inflammatory bowel disease. Fecal microbiota transplantation (FMT) for patients with ulcerative colitis (UC) is proposed as a potential approach to resolving their dysbiosis; however, its safety and efficacy have not been confirmed. This single-arm, open-label, non-randomized study aimed to evaluate the safety and efficacy of FMT for Japanese patients with UC as the first registered clinical trial in Japan...
January 2017: Intestinal Research
https://www.readbyqxmd.com/read/28235986/-fecal-microbiota-transplantation
#2
C Lübbert, B Salzberger, J Mössner
The human intestinal microbiome has important metabolic and immunological functions for the host and is part of the defense against pathogens in the gastrointestinal tract. Antibiotics, probiotics, dietary measures, such as prebiotics, and the relatively newly established method of fecal microbiota transplantation (FMT, also known as fecal microbiome transfer) all influence the intestinal microbiome. The FMT procedure comprises the transmission of fecal microorganisms from a healthy donor into the gastrointestinal tract of a patient...
February 24, 2017: Der Internist
https://www.readbyqxmd.com/read/28232086/microbiota-disruption-induced-by-early-use-of-broad-spectrum-antibiotics-is-an-independent-risk-factor-of-outcome-after-allogeneic-stem-cell-transplantation
#3
Daniela Weber, Robert R Jenq, Jonathan U Peled, Ying Taur, Andreas Hiergeist, Josef Koestler, Katja Dettmer, Markus Weber, Daniel Wolff, Joachim Hahn, Eric G Pamer, Wolfgang Herr, André Gessner, Peter J Oefner, Marcel R M van den Brink, Ernst Holler
In allogeneic stem cell transplantation (ASCT), systemic broad-spectrum antibiotics are frequently used for treatment of infectious complications, but their effect on microbiota composition is still poorly understood. Here, in a retrospective analysis of 621 patients, who underwent ASCT at the University Medical Center of Regensburg and Memorial Sloan Kettering Cancer Center in New York, we assessed the impact of timing of peri-transplant antibiotic treatment on intestinal microbiota composition as well as transplant-related mortality (TRM) and overall survival...
February 13, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28230610/16s-rdna-gene-sequencing-analysis-in-functional-dyspepsia-treated-with-fecal-microbiota-transplantation
#4
Jiayi Wang, Jianlei Gu, Yizhong Wang, Kai Lin, Shiyi Liu, Hui Lu, Ting Zhang, Guangjun Yu
No abstract text is available yet for this article.
March 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28196423/fecal-microbiota-transplantation-is-there-a-role-in-the-eradication-of-carbapenem-resistant-klebsiella-pneumoniae-intestinal-carriage
#5
Ana Ponte, Rolando Pinho, Margarida Mota
The authors present the case of a 66-year-old woman with four hospitalizations due to recurrent Clostridium difficile infection (CDI) non responsive to vancomycin and fidaxomicin. Furthermore, intestinal colonization with carbapenem-resistant Klebsiella pneumoniae (CRKP) was identified after a positive stool culture in a screening routinely performed in our center in patients recently hospitalized.
February 15, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28195180/successful-resolution-of-recurrent-clostridium-difficile-infection-using-freeze-dried-encapsulated-fecal-microbiota-pragmatic-cohort-study
#6
Christopher Staley, Matthew J Hamilton, Byron P Vaughn, Carolyn T Graiziger, Krista M Newman, Amanda J Kabage, Michael J Sadowsky, Alexander Khoruts
OBJECTIVES: Fecal microbiota transplantation (FMT) is increasingly being used for treatment of recurrent Clostridium difficile infection (R-CDI) that cannot be cured with antibiotics alone. In addition, FMT is being investigated for a variety of indications where restoration or restructuring of the gut microbial community is hypothesized to be beneficial. We sought to develop a stable, freeze-dried encapsulated preparation of standardized fecal microbiota that can be used for FMT with ease and convenience in clinical practice and research...
February 14, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28195066/successful-therapy-of-clostridium-difficile-infection-with-fecal-microbiota-transplantation
#7
P C Konturek, J Koziel, W Dieterich, D Haziri, S Wirtz, I Glowczyk, K Konturek, M F Neurath, Y Zopf
Clostridium difficile infection (CDI) is the most common cause of infectious diarrhea and represents an important burden for healthcare worldwide. Symptoms of severe CDI include watery, foul-smelling diarrhea, peripheral leucocytosis, increased C-reactive protein (CRP), acute renal failure, hypotension and pseudomembranous colitis. Recent studies indicate that the main cause of CDI is dysbiosis, an imbalance in the normal gut microbiota. The restoration of a healthy gut microbiota composition via fecal microbiota transplantation (FMT) recently became more popular...
December 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28187526/secondary-bile-acid-induced-dysbiosis-promotes-intestinal-carcinogenesis
#8
Hailong Cao, Mengque Xu, Wenxiao Dong, Baoru Deng, Sinan Wang, Yujie Zhang, Shan Wang, Shenhui Luo, Weiqiang Wang, Yanrong Qi, Jianxin Gao, Xiaocang Cao, Fang Yan, Bangmao Wang
The gut microbiota plays an important role in maintaining intestinal homeostasis. Dysbiosis is associated with intestinal tumorigenesis. Deoxycholic acid (DCA), a secondary bile acid increased by a western diet, is associated with intestinal carcinogenesis. However, evidence relating bile acids, intestinal microbiota and tumorigenesis is limited. In this study, we investigated the effect of DCA on induction of intestinal dysbiosis and its roles in intestinal carcinogenesis. Alteration of the composition of the intestinal microbiota was induced in DCA-treated mice, which was accompanied by impaired intestinal barrier, gut low grade inflammation and tumor progression...
February 10, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28181098/effect-of-aging-on-the-composition-of-fecal-microbiota-in-donors-for-fmt-and-its-impact-on-clinical-outcomes
#9
Rohit Anand, Yang Song, Shashank Garg, Mohit Girotra, Amitasha Sinha, Anita Sivaraman, Laila Phillips, Sudhir K Dutta
BACKGROUND: Fecal microbiota transplantation (FMT) is emerging as an effective therapy for the treatment of recurrent Clostridium difficile infection (RCDI). Selecting an appropriate donor is vital to the success of FMT. However, the relationship between age of donors and the efficacy of FMT has not been examined to date. The aim of this study was to examine the effect of age of healthy donors on their fecal microbiota and assess the impact of these changes on the clinical efficacy of FMT...
February 8, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28178876/designing-fecal-microbiota-transplant-trials-that-account-for-differences-in-donor-stool-efficacy
#10
Scott W Olesen, Thomas Gurry, Eric J Alm
Fecal microbiota transplantation is a highly effective intervention for patients suffering from recurrent Clostridium difficile, a common hospital-acquired infection. Fecal microbiota transplantation's success as a therapy for C. difficile has inspired interest in performing clinical trials that experiment with fecal microbiota transplantation as a therapy for other conditions like inflammatory bowel disease, obesity, diabetes, and Parkinson's disease. Results from clinical trials that use fecal microbiota transplantation to treat inflammatory bowel disease suggest that, for at least one condition beyond C...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/28178052/fecal-microbiota-transplant-for-clostridium-difficile-infection-in-a-pregnant-patient
#11
Bejan J Saeedi, Doree Gardner Morison, Colleen S Kraft, Tanvi Dhere
BACKGROUND: Clostridium difficile infection has been associated with negative outcomes in the general population and in pregnant patients. Fecal microbiota transplant has become the standard for treatment of recurrent as well as refractory C difficile infection. CASE: We present a case of a 28-year-old pregnant woman who presented with recurrent C difficile infection despite treatment with vancomycin and fidaxomicin and underwent a successful fecal microbiota transplant through colonoscopy at 18 weeks of gestation...
March 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28175249/p766-combination-therapy-of-fresh-fecal-microbial-transplantation-and-antibiotics-for-ulcerative-colitis
#12
D Ishikawa, M Takahashi, K Haga, T Shibuya, T Osada, S Watanabe
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174919/op030-identification-of-disease-relevant-bacterial-signatures-in-gnotobiotic-il-10-deficient-mice-using-fecal-samples-from-ibd-patients-undergoing-hematopoietic-stem-cell-transplantation
#13
A Metwaly, L F Butt, N Waldschmitt, I Lagkouvardos, A M Corraliza, A Mayorgas, M Martinez-Medina, M Allez, J Panes, A Salas, D Haller
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28164849/fecal-microbiota-transplantation
#14
REVIEW
Stephen M Vindigni, Christina M Surawicz
Fecal microbiota transplantation (FMT) is the transfer of stool from a healthy donor into the colon of a patient whose disease is a result of an altered microbiome, with the goal of restoring the normal microbiota and thus curing the disease. The most effective and well-studied indication for FMT is recurrent Clostridium difficile infection. At this time, there is insufficient evidence to recommend FMT for other gastrointestinal diseases, but studies are under way. There is also insufficient evidence to recommend FMT for nongastrointestinal diseases at this time...
March 2017: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/28158664/fecal-microbiota-transplant-versus-oral-vancomycin-taper-important-undiscussed-limitations
#15
Jeffrey W Jansen
No abstract text is available yet for this article.
February 3, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28158478/fecal-microbiota-transplantation-do-we-need-harmonization
#16
Tatiana Galpérine, Harry Sokol, Benoît Guery
No abstract text is available yet for this article.
February 3, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28158276/fecal-microbiota-transplantation-in-patients-with-slow-transit-constipation-a-randomized-clinical-trial
#17
Hongliang Tian, Xiaolong Ge, Yongzhan Nie, Linfeng Yang, Chao Ding, Lynne V McFarland, Xueying Zhang, Qiyi Chen, Jianfeng Gong, Ning Li
Fecal microbiota transplantation has been proposed as a therapeutic approach for chronic constipation. This randomized, controlled trial aimed to compare the effects of conventional treatment alone (control) with additional treatment with FMT (intervention) in patients with slow-transit constipation (STC). Adults with STC were randomized to receive intervention or control treatment. The control group received education, behavioral strategies, and oral laxatives. The intervention group was additionally provided 6 days of FMT...
2017: PloS One
https://www.readbyqxmd.com/read/28157682/fecal-microbiota-transplantation-for-agvhd-of-the-gut
#18
(no author information available yet)
No abstract text is available yet for this article.
October 20, 2016: Blood
https://www.readbyqxmd.com/read/28154388/possible-alternative-predictors-of-failure-of-fecal-microbiota-transplant-for-therapy-of-recurrent-c-difficile-infection
#19
Vimal Bodiwala, Kevin Skole
No abstract text is available yet for this article.
February 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28154090/repeated-fecal-microbiota-transplantations-attenuate-diarrhea-and-lead-to-sustained-changes-in-the-fecal-microbiota-in-acute-refractory-gastrointestinal-graft-versus-host-disease
#20
Walter Spindelboeck, Eduard Schulz, Barbara Uhl, Karl Kashofer, Ariane Aigelsreiter, Wilma Zinke-Cerwenka, Adnan Mulabecirovic, Patrizia K Kump, Bettina Halwachs, Gregor Gorkiewicz, Heinz Sill, Hildegard Greinix, Christoph Högenauer, Peter Neumeister
No abstract text is available yet for this article.
February 2, 2017: Haematologica
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