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https://www.readbyqxmd.com/read/29158082/successful-treatment-by-fecal-microbiota-transplantation-for-japanese-patients-with-refractory-clostridium-difficile-infection-a%C3%A2-prospective-case-series
#1
Shigeki Bamba, Atsushi Nishida, Hirotsugu Imaeda, Osamu Inatomi, Masaya Sasaki, Mitsushige Sugimoto, Akira Andoh
We prospectively enrolled four Japanese patients with refractory Clostridium difficile infection (CDI) and were treated with a single fecal microbiota transplantation (FMT). The average age of the patients was 83.7 years. All patients had a successful clinical course for up to 3 months without any adverse events.
November 5, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29157127/modulation-of-the-gut-microbiota-by-metformin-improves-metabolic-profiles-in-aged-obese-mice
#2
Heetae Lee, Youngjoo Lee, Jiyeon Kim, Jinho An, Sungwon Lee, Hyunseok Kong, Youngcheon Song, Chong-Kil Lee, Kyungjae Kim
The gut microbiota is a contributing factor in obesity-related metabolic disorders. The effect of metformin on the gut microbiota has been reported; however, the relationship between the gut microbiota and the mechanism of action of metformin in elderly individuals is unclear. In this study, the effect of metformin on the gut microbiota was investigated in aged obese mice. The abundance of the genera Akkermansia, Bacteroides, Butyricimonas, and Parabacteroides was significantly increased by metformin in mice fed a high-fat diet...
November 20, 2017: Gut Microbes
https://www.readbyqxmd.com/read/29152407/fecal-microbiota-transplantation-against-irritable-bowel-syndrome-rigorous-randomized-clinical-trials-are-required
#3
Amin Talebi Bezmin Abadi
Halkjær et al searched systematically nine articles including 48 patients, and concluded that fecal microbiota transplantation (FMT) can be an ideal treatment option for irritable bowel syndrome (IBS) subjects. Regardless of the few successes in current traditional therapies (change in diet, herbal medicine and antibiotics) in IBS, a sharp increase in interests in the FMT option has been reported in the current century. However, there is a long list of unclear issues concerning the application of FMT for the treatment of IBS...
November 6, 2017: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29151426/-effects-of-antibiotics-on-intestinal-microflora-and-intestinal-mucosal-barrier-function-and-its-mechanisms
#4
Yue Han, Yuxin Leng, Gaiqi Yao
Antibiotics are the cornerstone to cure infectious diseases, however, it also destroys the intestinal inherent microflora, and may cause serious gastrointestinal dysfunction, such as abdominal distension, diarrhea, mucosal barrier damage etc. In severe conditions, it may induce intestinal sepsis. With the development of the human microbiology group program and the popularity of microbial sequencing technology, people can comprehend the effects of antibiotics on intestinal flora deeply, meanwhile the traditional biomedical model (the basis of bacterial disease) is questioned...
November 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29151253/a-two-week-fecal-microbiota-transplantation-course-in-pediatric-patients-with-inflammatory-bowel-disease
#5
Katarzyna Karolewska-Bochenek, Pawel Grzesiowski, Aleksandra Banaszkiewicz, Agnieszka Gawronska, Maria Kotowska, Marcin Dziekiewicz, Piotr Albrecht, Andrzej Radzikowski, Izabella Lazowska-Przeorek
Dysbiosis plays a major role in the etiology of inflammatory bowel disease (IBD). Fecal microbiota transplantation (FMT) is a new promising option for IBD treatment. We aimed to assess the effectiveness of a two-week FMT course in children with IBD. Ten patients, 10-17 years of age with moderate to severe IBD received a course of eight doses of freshly prepared FMT via a naso-duodenal tube or gastroscopy. All of the patients had pancolitis. There were eight cases of ulcerative colitis (UC) and two of Crohn's disease (CD)...
November 19, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29138633/influence-of-spk-with-enteric-drainage-on-the-pancreatic-exocrine-function-in-diabetic-patients-with-uremia
#6
Guanghui Pei, Wu Lv, Xiaohang Li, Guoqing Zhang, Jialin Zhang
Objective: This study aimed to determine the use of fecal elastase in evaluating the effect of simultaneous pancreas-kidney transplantation with enteric drainage on the pancreatic exocrine function of diabetic patients with uremia. Methods: A total of 19 patients with simultaneous pancreas-kidney transplantation (SPK) with enteric drainage, 31 diabetic patients with uremia (chronic renal failure (CRF)), 22 diabetic patients with uremia who underwent renal transplantation (RT), and 20 normal individuals (CON) were included in the study...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29134299/fecal-transplantation-for-treatment-of-clostridium-difficile-infection-in-elderly-and-debilitated-patients
#7
Tali Friedman-Korn, Dan Meir Livovsky, Nitsan Maharshak, Nathaniel Aviv Cohen, Kalman Paz, Ariella Bar-Gil Shitrit, Eran Goldin, Benjamin Koslowsky
BACKGROUND: Fecal microbiota transplantation (FMT) is a new technique recently introduced to treat recurrent Clostridium difficile infection (CDI). Little is known about the efficacy and risks of FMT in elderly and ill patients. AIM: To investigate FMT efficacy in ill and elderly patients compared to conventional treatment. METHODS: The study comprised two groups of patients between 2012 and 2016 with recurrent CDI at two medical centers in Israel...
November 13, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29132532/emerging-topics-in-gastroenterology
#8
REVIEW
Gretchen Irwin, Laura Mayans, Rick Kellerman
The bacteria and fungi in the human gut make up a community of microorganisms that lives in symbiosis with humans, engaging in numerous diverse interactions that influence health. This article outlines the current knowledge on emerging topics in gastroenterology, including microbiome and probiotics, fecal microbiota transplantation, cyclic vomiting syndrome, eosinophilic esophagitis, and microscopic colitis.
December 2017: Primary Care
https://www.readbyqxmd.com/read/29130220/-current-research-progress-and-thinking-of-fecal-microbiota-transplantation-for-the-treatment-of-gastrointestinal-disorders
#9
Ning Li, Hongliang Tian
Fecal microbiota transplantation (FMT), also known as fecal bacteriotherapy or fecal infusion, consists of injection of a liquid filtrate of feces from a healthy donor into the gastrointestinal tract of a recipient individual. FMT has been proposed as a therapeutic approach for functional diseases of the gastrointestinal tract by reestablishment of a wide diversity of intestinal flora. Clostridium difficile infection (CDI) treatment guideline from American Gastroenterology Association (AGA) recommends that FMT can be used as the treatment protocols of relapse CDI...
October 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29124320/recipe-for-ibd-can-we-use-food-to-control-inflammatory-bowel-disease
#10
REVIEW
Mario Witkowski, Marco Witkowski, Nicola Gagliani, Samuel Huber
The mucosal immune system and the microbiota in the intestinal tract have recently been shown to play a key role in the pathogenesis of inflammatory bowel disease (IBD). Both of these can be influenced by food. Thus, we propose dietary intervention as a therapeutic option for IBD. In this review, we discuss the interaction of the intestinal mucosal immune system and the intestinal microbiota in the context of IBD. In addition, we discuss the impact of food components on immune responses in IBD. Finally, we address the current evidence of how this interaction (i...
November 9, 2017: Seminars in Immunopathology
https://www.readbyqxmd.com/read/29124041/alteration-of-gut-microbiota-and-inflammatory-cytokine-chemokine-profiles-in-5-fluorouracil-induced-intestinal-mucositis
#11
Hong-Li Li, Lan Lu, Xiao-Shuang Wang, Li-Yue Qin, Ping Wang, Shui-Ping Qiu, Hui Wu, Fei Huang, Bei-Bei Zhang, Hai-Lian Shi, Xiao-Jun Wu
Disturbed homeostasis of gut microbiota has been suggested to be closely associated with 5-fluorouracil (5-Fu) induced mucositis. However, current knowledge of the overall profiles of 5-Fu-disturbed gut microbiota is limited, and so far there is no direct convincing evidence proving the causality between 5-Fu-disturbed microbiota and colonic mucositis. In mice, in agreement with previous reports, 5-Fu resulted in severe colonic mucositis indicated by weight loss, diarrhea, bloody stool, shortened colon, and infiltration of inflammatory cells...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29123385/clostridium-difficile-infection-in-the-elderly-an-update-on-management
#12
REVIEW
Tomefa E Asempa, David P Nicolau
The burden of Clostridium difficile infection (CDI) is profound and growing. CDI now represents a common cause of health care-associated diarrhea, and is associated with significant morbidity, mortality, and health care costs. CDI disproportionally affects the elderly, possibly explained by the following risk factors: age-related impairment of the immune system, increasing antibiotic utilization, and frequent health care exposure. In the USA, recent epidemiological studies estimate that two out of every three health care-associated CDIs occur in patients 65 years or older...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29114399/erratum-author-correction-identification-of-donor-microbe-species-that-colonize-and-persist-long-term-in-the-recipient-after-fecal-transplant-for-recurrent-clostridium-difficile
#13
Ranjit Kumar, Nengjun Yi, Degui Zhi, Peter Eipers, Kelly T Goldsmith, Paula Dixon, David K Crossman, Michael R Crowley, Elliot J Lefkowitz, J Martin Rodriguez, Casey D Morrow
[This corrects the article DOI: 10.1038/s41522-017-0020-7.].
2017: NPJ Biofilms and Microbiomes
https://www.readbyqxmd.com/read/29110105/recent-issues-in-pediatric-clostridium-difficile-infection
#14
REVIEW
Jason A Clayton, Philip Toltzis
PURPOSE OF REVIEW: We focus on two recent aspects of Clostridium difficile infection (CDI) in children, namely the emergence of community-associated CDI (CA-CDI) and the incidence and prevention of recurrent CDI. RECENT FINDINGS: Current surveys suggest that a large proportion of all pediatric CDI is acquired in the community. Risk factors and frequency estimates of pediatric CA-CDI, however, are confounded in babies and toddlers by a high rate of asymptomatic excretion, whose detection likely is exaggerated by the wide use of highly sensitive nucleic acid amplification tests...
November 7, 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29107964/obesogenic-diet-induced-gut-barrier-dysfunction-and-pathobiont-expansion-aggravate-experimental-colitis
#15
June-Chul Lee, Hae-Youn Lee, Tae Kang Kim, Min-Soo Kim, Young Mi Park, Jinyoung Kim, Kihyoun Park, Mi-Na Kweon, Seok-Hyung Kim, Jin-Woo Bae, Kyu Yeon Hur, Myung-Shik Lee
Consumption of a typical Western diet is a risk factor for several disorders. Metabolic syndrome is the most common disease associated with intake of excess fat. However, the incidence of inflammatory bowel disease is also greater in subjects consuming a Western diet, although the mechanism of this phenomenon is not clearly understood. We examined the morphological and functional changes of the intestine, the first site contacting dietary fat, in mice fed a high-fat diet (HFD) inducing obesity. Paneth cell area and production of antimicrobial peptides by Paneth cells were decreased in HFD-fed mice...
2017: PloS One
https://www.readbyqxmd.com/read/29104169/asymptomatic-clostridium-difficile-carriage-rate-post-fecal-microbiota-transplant-is-low-a-prospective-clinical-and-stool-assessment
#16
Jessica R Allegretti, Andrew Allegretti, Emmalee Phelps, Huiping Xu, Zain Kassam, Monika Fischer
OBJECTIVES: We aimed to assess the asymptomatic C. difficile carriage rates following FMT. METHODS: All patients who underwent FMT for recurrent CDI via colonoscopy or sigmoidoscopy between June 2013 and April 2015 and had a minimum of 8-week follow-up post-FMT at two tertiary care referral centers were included in the study. Patients were prospectively followed both clinically and with stool assessments for 8 weeks post FMT. Assessments occurred at 1 week and 4 weeks post-FMT to assess for failure...
November 2, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29104129/classifying-fecal-microbiota-transplantation-failure-an-observational-study-examining-timing-and-characteristics-of-fmt-failures
#17
Jessica R Allegretti, Emmalee Phelps, Andrew Allegretti, Huiping Xu, Monika Fischer, Zain Kassam
No abstract text is available yet for this article.
November 2, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29102616/cost-effectiveness-of-screening-individuals-with-cystic-fibrosis-for-colorectal-cancer
#18
Andrea Gini, Ann G Zauber, Dayna R Cenin, Amir-Houshang Omidvari, Sarah E Hempstead, Aliza K Fink, Albert B Lowenfels, Iris Lansdorp-Vogelaar
BACKGROUND & AIMS: Individuals with cystic fibrosis are at increased risk of colorectal cancer (CRC) compared to the general population, and risk is higher among those who received an organ transplant. We performed a cost-effectiveness analysis to determine optimal CRC screening strategies for patients with cystic fibrosis. METHODS: We adjusted the existing MISCAN-Colon microsimulation model to reflect increased CRC risk and lower life-expectancy in patients with cystic fibrosis...
November 1, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29101931/safety-and-efficacy-of-fecal-microbiota-transplant-for-recurrent-clostridium-difficile-infection-in-patients-with-cancer-treated-with-cytotoxic-chemotherapy-a-single-institution-retrospective-case-series
#19
Mehrdad Hefazi, Mrinal M Patnaik, William J Hogan, Mark R Litzow, Darrell S Pardi, Sahil Khanna
OBJECTIVE: To study the safety and efficacy of fecal microbiota transplant (FMT) for Clostridium difficile infection (CDI) in patients with cancer treated with cytotoxic chemotherapy in a single-institution retrospective case series. PATIENTS AND METHODS: Twenty-three consecutive patients with underlying hematologic (n=13) or solid (n=10) malignancies who underwent FMT for recurrent CDI from August 1, 2012, through June 30, 2016, were studied. RESULTS: All the patients had received cytotoxic chemotherapy a median of 12 months (range, 1-340 months) before FMT...
November 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29101192/fecal-microbiota-transplant-from-highly-feed-efficient-donors-shows-little-effects-on-age-related-changes-in-feed-efficiency-associated-fecal-microbiota-in-chickens
#20
Sina-Catherine Siegerstetter, Renée M Petri, Elizabeth Magowan, Peadar G Lawlor, Qendrim Zebeli, Niamh E O'Connell, Barbara U Metzler-Zebeli
Chickens of good and poor feed efficiency (FE) have been shown to differ in their intestinal microbiota composition. This study investigated differences in the fecal bacterial community of good and poor feed efficient chickens at 16 and 29 days post-hatch (dph) and evaluated whether a fecal microbiota transplant (FMT) from feed efficient donors early in life can affect the fecal microbiota in chickens at 16 and 29 dph, chicken's FE and nutrient retention at four weeks of age. One-hundred-ten chickens were inoculated with a FMT or a control transplant (CT) on 1, 6 and 9 dph and ranked according to residual feed intake (RFI; metric for FE) on 30 dph...
November 3, 2017: Applied and Environmental Microbiology
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