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https://www.readbyqxmd.com/read/29673911/targeting-the-rhoa-rock-pathway-to-regulate-t-cell-homeostasis-in-hypoxia-induced-pulmonary-arterial-hypertension
#1
Cheng Li, Ping-Ping Liu, Dou-Dou Tang, Rong Song, Yi-Qing Zhang, Si Lei, Shang-Jie Wu
BACKGROUND: Hypoxic pulmonary arterial hypertension (PAH) is a crippling disease with limited therapeutic methods. The imbalance of T helper 17 cell (Th17)/regulatory T cell (Treg) plays an important role in the development of Hypoxic PAH. However, whether targeting the ras homolog family member A-Rho kinase (RhoA-ROCK) pathway (activation and inhibition) by lysophosphatidic acid (LPA) and fasudil (FSD) regulate T-cell homeostasis in Hypoxic PAH remain unknown. OBJECTIVE: To examine the effects of LPA and FSD on hypoxic pulmonary vascular remodeling and homeostasis of Th17/Treg cells in Hypoxic PAH...
April 16, 2018: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29673854/silencing-of-non-pou-domain-containing-octamer-binding-protein-stabilizes-atherosclerotic-plaque-in-apolipoprotein-e-knockout-mice-via-nf-%C3%AE%C2%BAb-signaling-pathway
#2
Kai Zhang, Fang Zhang, Jian-Min Yang, Jing Kong, Xiao Meng, Meng Zhang, Cheng Zhang, Yun Zhang
BACKGROUND: It remains unknown whether Non-POU-domain-containing octamer-binding protein (NonO) plays a causative role in plaque destabilization. We hypothesized that NonO gene silencing may stabilize atherosclerotic plaque by increasing P4Hα1 expression and inhibiting the inflammation. METHODS AND RESULTS: Vulnerable atherosclerotic plaques were induced in ApoE-/- mice by high fat diet, perivascular collar placement and mental stress. Compared with normal carotid arteries, those contained vulnerable plaques had high NonO expression...
April 7, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29669712/er-chaperone-grp78-protects-heart-from-ischemia-reperfusion-injury-through-akt-activation
#3
Xukun Bi, Guangyu Zhang, Xiaoding Wang, Chau Yt Nguyen, Herman I May, Xiaoting Li, Ali Al-Hashimi, Richard C Austin, Thomas G Gillette, Guo Sheng Fu, Zhao V Wang, Joseph A Hill
<u>Rationale:</u> Restoration of coronary artery blood flow is the most effective means of ameliorating myocardial damage triggered by ischemic heart disease. However, coronary reperfusion elicits an increment of additional injury to the myocardium. Accumulating evidence indicates that the unfolded protein response (UPR) in cardiomyocytes is activated by ischemia/reperfusion (I/R) injury. Xbp1s, the most highly conserved branch of the UPR, is protective in response to cardiac I/R injury. GRP78, a master regulator of the UPR and an Xbp1s target, is up-regulated after I/R...
April 18, 2018: Circulation Research
https://www.readbyqxmd.com/read/29668531/correlation-between-extended-leukocyte-differential-count-and-coronary-artery-disease
#4
Si Chen, Shulan Zhang, Haixia Luan, Xiaoli Zeng, Yongzhe Li, Hui Yuan
BACKGROUND: Leukocyte count is closely associated with the risk of coronary artery disease (CAD). Levels of leukocyte subpopulations in CAD patients, however, remain largely unknown. METHODS: In the present study, we compared the distributions and counts of 16 leukocyte subpopulations between 40 CAD patients and 40 healthy controls using the CytoDiff flow cytometric system. RESULTS: Our results demonstrated significant increases in the frequencies and counts of all monocytes, immature granulocytes and B-lymphocytes in CAD patients, suggesting the levels of these leukocyte subpopulations may serve as potential biomarkers for diagnosis of CAD...
April 10, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29661678/effect-of-predosing-versus-slow-administration-of-propofol-on-the-dose-required-for-anaesthetic-induction-and-on-physiologic-variables-in-healthy-dogs
#5
Mathieu Raillard, Emma J Love, Pamela J Murison
OBJECTIVE: To investigate the effects of the timing of propofol administration on the dose required for induction of anaesthesia and commonly measured physiological effects. STUDY DESIGN: Randomized, investigator-blinded clinical study. ANIMALS: A group of 32 healthy dogs aged 6-144 months and weighing 3.5-47.2 kg. METHODS: Premedication was intramuscular acepromazine (0.025 mg kg-1 ) and methadone (0.25 mg kg-1 )...
March 6, 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29652681/direct-ultrasound-of-the-pulmonary-artery-helps-diagnose-a-rare-cause-of-right-ventricular-failure-after-heart-transplantation-a-case-report
#6
John S McNeil, Si M Pham, Julie L Huffmyer
Pulmonary artery anastomosis stenosis is a rare cause of right ventricular failure after orthotopic heart transplantation. In this case report, direct ultrasound of the pulmonary artery helped diagnose stenosis at a location not visible on transesophageal echocardiography or even with standard epicardial ultrasound views. It is important to evaluate all vascular anastomoses after heart or lung transplantation because surgical revision of these lesions is facile, but if left undiagnosed, significant morbidity or mortality is likely...
April 15, 2018: A&A practice
https://www.readbyqxmd.com/read/29623009/multifunctional-biomedical-imaging-in-physiological-and-pathological-conditions-using-a-nir-ii-probe
#7
Kangquan Shou, Chunrong Qu, Yao Sun, Hao Chen, Si Chen, Lei Zhang, Haibo Xu, Xuechuan Hong, Aixi Yu, Zhen Cheng
Compared with imaging in the visible (400 - 650 nm) and near-infrared window I (NIR-I, 650 - 900 nm) regions, imaging in near-infrared window II (NIR-II, 1,000-1,700 nm) is a highly promising in vivo imaging modality with improved resolution and deeper tissue penetration. In this work, a small molecule NIR-II dye,5,5'-(1H,5H-benzo[1,2-c:4,5-c'] bis[1,2,5]thiadiazole)-4,8-diyl)bis(N,N-bis(4-(3-((tert-butyldimethylsilyl)oxy)propyl)phenyl) thiophen-2-amine), has been successfully encapsulated into phospholipid vesicles to prepare a probe CQS1000...
June 20, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/29622593/transient-receptor-potential-melastatin-8-activation-induces-relaxation-of-pulmonary-artery-by-inhibition-of-store-operated-calcium-entry-in-normoxic-and-chronic-hypoxic-pulmonary-hypertensive-rats
#8
Yun-Ping Mu, Da-Cen Lin, Si-Yi Zheng, Hai-Xia Jiao, James Sham, Mo-Jun Lin
Pulmonary hypertension (PH) is characterized by enhanced vasoconstriction and vascular remodeling, which are attributable to the alteration of Ca2+ homeostasis in pulmonary arterial smooth muscle cells (PASMCs). It is well established that store-operated Ca2+ entry (SOCE) is augmented in PASMCs during PH and it plays crucial roles in PH development. Our previous studies showed that the melastatin-related transient receptor potential 8 (TRPM8) is down-regulated in PASMCs of PH animal models; and activation of TRPM8 causes relaxation of pulmonary arteries (PAs)...
April 5, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29604599/garlic-extract-favorably-modifies-markers-of-endothelial-function-in-obese-patients-randomized-double-blind-placebo-controlled-nutritional-intervention
#9
Monika Szulińska, Matylda Kręgielska-Narożna, Joanna Świątek, Paulina Styś, Barbara Kuźnar-Kamińska, Hieronim Jakubowski, Jarosław Walkowiak, Paweł Bogdański
OBJECTIVE: Garlic exerts a range of effects relevant to human health. However, its influence on the endothelium in obese individuals remains unknown. We aimed to determine the effects of garlic extract (GE) on arterial stiffness and markers of endothelial function. METHODS: Ninety-two subjects were enrolled in this study. The participants were randomly assigned to receive 400 mg of GE or placebo daily for 3 months. The arterial stiffness index (SI) and markers of endothelial function such as high-sensitivity C-reactive protein (hsCRP), cholesterol (total, LDL, HDL), triglycerides, and plasminogen activator inhibitor 1 (PAI-1), as well as total antioxidant status (TAS) were quantified at baseline and the end of study...
March 28, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29578029/ubo-detector-a-cluster-based-fully-automated-pipeline-for-extracting-white-matter-hyperintensities
#10
Jiyang Jiang, Tao Liu, Wanlin Zhu, Rebecca Koncz, Hao Liu, Teresa Lee, Perminder S Sachdev, Wei Wen
We present 'UBO Detector', a cluster-based, fully automated pipeline for extracting and calculating variables for regions of white matter hyperintensities (WMH) (available for download at https://cheba.unsw.edu.au/group/neuroimaging-pipeline). It takes T1-weighted and fluid attenuated inversion recovery (FLAIR) scans as input, and SPM12 and FSL functions are utilised for pre-processing. The candidate clusters are then generated by FMRIB's Automated Segmentation Tool (FAST). A supervised machine learning algorithm, k-nearest neighbor (k-NN), is applied to determine whether the candidate clusters are WMH or non-WMH...
March 22, 2018: NeuroImage
https://www.readbyqxmd.com/read/29572603/risk-factor-analysis-of-recanalization-and-retreatment-for-patients-with-endovascular-treatment-of-internal-carotid-artery-bifurcation-aneurysms
#11
Seung Pil Ban, Gyojun Hwang, Chang Hyeun Kim, Hyoung Soo Byoun, Si Un Lee, Tackeun Kim, Jae Seung Bang, Chang Wan Oh, O-Ki Kwon
PURPOSE: Only a few reports of internal carotid artery (ICA) bifurcation aneurysms using the endovascular technique have been published in the current literature. The purpose of this study was to assess how multiple risk factors including angioarchitectural features of ICA bifurcation characteristics may have influenced aneurysmal rupture, recanalization, and retreatment. METHODS: Fifty-one patients with 52 ICA bifurcation aneurysms treated with endovascular coiling between July 2003 and July 2015 were retrospectively analyzed...
March 23, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29535351/fully-printed-wearable-vital-sensor-for-human-pulse-rate-monitoring-using-ferroelectric-polymer
#12
Tomohito Sekine, Ryo Sugano, Tomoya Tashiro, Jun Sato, Yasunori Takeda, Hiroyuki Matsui, Daisuke Kumaki, Fabrice Domingues Dos Santos, Atsushi Miyabo, Shizuo Tokito
The ability to monitor subtle changes in vital and arterial signals using flexible devices attached to the human skin can be valuable for the detection of various health conditions such as cardiovascular disease. Conventional Si device technologies are being utilised in traditional clinical systems; however, its fabrication is not easy owing to the difficulties in adapting to conventional processes. Here, we present the development of a fully printed, wearable, ferroelectric-polymer vital sensor for monitoring the human pulse wave/rate on the skin...
March 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29526680/endothelial-dysfunction-of-coronary-arteries-in-subjects-without-diabetes-an-association-with-both-insulin-resistance-and-impaired-insulin-secretion-response
#13
Katarina Lalić, Milan Nedeljković, Alekasandra Jotić, Rade Babić, Nataša Rajković, Ljiljana Popović, Ljiljana Lukić, Tanja Miličić, Sandra Singh Lukač, Ljubica Stošić, Marija Maćešić, Iva Rasulić, Jelena Stanarčić Gajović, Nebojša M Lalić
AIMS: This study was aimed to compare insulin sensitivity and secretion response, lipoprotein and plasminogen activator inhibitor 1 (PAI-1) levels between the subjects with and without coronary artery endothelial dysfunction (ED). METHODS: ED was detected by intracoronary injection of acetylcholine (ACh) in 47 nondiabetes subjects without stenotic coronary arteries, selected from 316 consecutive patients with coronary angiography performed for suspected coronary artery disease...
March 8, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29516010/systematic-analysis-of-rna-regulatory-network-in-rat-brain-after-ischemic-stroke
#14
Juan Liu, Kun-Shan Zhang, Bin Hu, Si-Guang Li, Qing Li, Yu-Ping Luo, Yang Wang, Zhi-Feng Deng
Although extensive studies have identified large number of microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) in ischemic stroke, the RNA regulation network response to focal ischemia remains poorly understood. In this study, we simultaneously interrogate the expression profiles of lncRNAs, miRNAs, and mRNAs changes during focal ischemia induced by transient middle cerebral artery occlusion. A set of 1924 novel lncRNAs were identified and may involve brain injury and DNA repair as revealed by coexpression network analysis...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29511499/mir-103-regulates-the-angiogenesis-of-ischemic-stroke-rats-by-targeting-vascular-endothelial-growth-factor-vegf
#15
Fu-Ping Shi, Xue-Hong Wang, Hong-Xin Zhang, Meng-Meng Shang, Xiao-Xi Liu, Hai-Min Sun, Yue-Ping Song
Objectives: To investigate the effect of miR-103 on the angiogenesis of ischemic stroke rats via targeting vascular endothelial growth factor (VEGF) at the molecular level. Materials and Methods: Rat models had received the middle cerebral artery occlusion (MCAO) or sham operation before grouping, and cell models of oxygen-glucose deprivation (OGD) were performed. FITC-dextran, matrigel, and Trans-well assays were used to evaluate the vascular density, tube formation, and cell migration respectively...
March 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29510176/association-between-p2ry12-gene-polymorphisms-and-adverse-clinical-events-in-coronary-artery-disease-patients-treated-with-clopidogrel-a-systematic-review-and-meta-analysis
#16
REVIEW
Jun-Lei Li, Yu Fu, Si-Bei Qin, Guang-Kai Liang, Jian Liu, Xiao-Yan Nie, Jing Chen, Lu-Wen Shi, Hong Shao, Yun Lu
OBJECTIVE: Investigate the association between P2Y12 Purinoceptor (P2RY12) polymorphisms and adverse clinical events in coronary artery disease (CAD) patients treated with clopidogrel. METHODS: We performed a comprehensive database search, with a particular focus on P2RY12 polymorphisms and their effects in clopidogrel-treated CAD patients, in the PubMed, EMBASE, Cochrane Library, clinicaltrials.gov, Web of Science, and Chinese databases from their inceptions to April 8, 2017...
March 3, 2018: Gene
https://www.readbyqxmd.com/read/29505952/reduced-substantia-innominata-volume-mediates-contributions-of-microvascular-and-macrovascular-disease-to-cognitive-deficits-in-alzheimer-s-disease
#17
Gurpreet Jaswal, Walter Swardfager, Fu-Qiang Gao, Sean M Nestor, Anoop Ganda, Hugo Cogo-Moreira, Demetrios J Sahlas, Donald T Stuss, Alan Moody, Sandra E Black
The relationships between cholinergic system damage and cerebrovascular disease are not entirely understood. Here, we investigate associations between atrophy of the substantia innominata (SI; the origin of cortical cholinergic projections) and measures of large and small vessel disease; specifically, elongation of the juxtaposed internal carotid artery termination and Cholinergic Pathways Hyperintensity scores (CHIPS). The study (n = 105) consisted of patients with Alzheimer's disease (AD) and/or subcortical ischemic vasculopathy, and elderly controls...
February 10, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29504087/the-diagnostic-utility-of-d-dimer-and-other-clinical-variables-in-pregnant-and-post-partum-patients-with-suspected-acute-pulmonary-embolism
#18
Hyun Choi, Dinesh Krishnamoorthy
BACKGROUND: Pulmonary embolism (PE) during pregnancy remains one of the leading causes of maternal morbidity and mortality in the developed world. However, there is a paucity of high-quality evidence resulting in a lack of consensus in managing this group of patients. The aims of the study were to address the diagnostic utility of D-dimer for suspected PE in pregnant and post-partum patients and to identify any clinical presentation variables that are predictors of PE in this group of patients...
March 5, 2018: International Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29485979/hydrogen-sulfide-attenuates-hypertensive-inflammation-via-regulating-connexin-expression-in-spontaneously-hypertensive-rats
#19
Xin Ni, Liang Zhang, Min Peng, Tu-Wang Shen, Xiu-Shi Yu, Li-Ya Shan, Li Li, Jun-Qiang Si, Xin-Zhi Li, Ke-Tao Ma
BACKGROUND Hydrogen sulfide (H2S) has anti-inflammatory and anti-hypertensive effects, and connexins (Cxs) are involved in regulation of immune homeostasis. In this study, we explored whether exogenous H2S prevents hypertensive inflammation by regulating Cxs expression of T lymphocytes in spontaneously hypertensive rats (SHR). MATERIAL AND METHODS We treated SHR with sodium hydrosulfide (NaHS) for 9 weeks. Vehicle-treated Wistar-Kyoto rats (WKYs) were used as a control. The arterial pressure was monitored by the tail-cuff method, and vascular function in basilar arteries was examined by pressure myography...
February 27, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29472090/non-invasive-characterization-of-coronary-artery-atherosclerotic-plaque-using-dual-energy-ct-explanation-in-ex-vivo-samples
#20
Susama Rani Mandal, Avinav Bharati, Rezvan Ravanfar Haghighi, Sudhir Arava, Ruma Ray, Priya Jagia, Sanjiv Sharma, Sabyasachi Chatterjee, Millo Tabin, Munish Sharma, Sanjay Sharma, Pratik Kumar
PURPOSE: In this study non-calcified plaque composition is evaluated by Dual Energy CT (DECT). Energy Dispersive X-ray Spectroscopy (EDS) has been used to study the Plaque composition. An attempt has been made to explain the DECT results with EDS analysis. METHODS: Thirty-two ex-vivo human cadaver coronary artery samples were scanned by DECT and data was evaluated to calculate their effective atomic number and electron density (Zeff & ρe ) by inversion method...
January 2018: Physica Medica: PM
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