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https://www.readbyqxmd.com/read/28108813/relationship-between-il-27-and-coronary-arterial-lesions-in-children-with-kawasaki-disease
#1
Feifei Si, Yao Wu, Fang Gao, Siqi Feng, Ruixi Liu, Qijian Yi
Kawasaki disease (KD) arises due to the disorder of the inflammation response and faulty immune regulation. Interleukin-27 (IL-27) is a novel cytokine with both pro-inflammatory and anti-inflammatory effects. This study investigated the relationship between serum levels of IL-27, Interleukin-17A (IL-17A), Interleukin-10 (IL-10), Interleukin-6 (IL-6), Interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and coronary artery lesions (CALs) in patients with KD. We obtained blood samples from 81 children with KD before intravenous immunoglobulin (IVIG) therapy...
January 20, 2017: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/28106289/the-involvement-of-corin-in-the-progression-of-diabetic-erectile-dysfunction-in-a-rat-model-by-down-regulating-anp-no-cgmp-signal-pathway
#2
Jian Wang, Yuanyuan Mi, Fenglai Yuan, Sheng Wu, Xiaoming You, Feng Dai, Yi Huang, Jia Cao, Jin Zhu, Boxin Xue, Lijie Zhu
This study was aimed to analyze the potential role of Corin in the procession of diabetic ED and to explore the underlying mechanism. Diabetic ED rat model was constructed and the characteristics of diabetic ED and control rats were recorded at 4, 8, 12 and 16 weeks. qRT-PCR and Western bloting were used to detected the mRNA and protein levels. Intracellular cGMP detection was accomplished using a commercial radioimmunoassay method. Vascular endothelial cell from rat corpus cavernosum spiral artery was isolated and transfected with si- Corin to analyzed the potential role of Corin...
January 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28094277/peripheral-arterial-volume-distensibility-changes-with-applied-external-pressure-significant-difference-between-arteries-with-different-compliance
#3
Mengyan Chen, Aiqing Chen, Xiaoshui Si, Mingxia Ji, Dingchang Zheng
This study aimed to quantify the different effect of external cuff pressure on arterial volume distensibility between peripheral arteries with different compliance. 30 healthy subjects were studied with the arm at two positions (0° and 45° from the horizontal level) to introduce different compliance of arteries. The electrocardiogram and finger and ear photoplethysmograms were recorded simultaneously under five external cuff pressures (0, 10, 20, 30 and 40 mmHg) on the whole arm to obtain arterial volume distensibility...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28043202/sex-specific-cardiopulmonary-exercise-testing-indices-related-to-hemodynamics-in-idiopathic-pulmonary-arterial-hypertension
#4
Ping Yuan, Tian-Xiang Chen, Bigyan Pudasaini, Jie Zhang, Jian Guo, Si-Jin Zhang, Lan Wang, Qin-Hua Zhao, Su-Gang Gong, Rong Jiang, Wen-Hui Wu, Jing He, Jin-Ming Liu, Qing-Hua Hu
BACKGROUND: Many studies have highlighted sex preponderance in idiopathic pulmonary arterial hypertension (IPAH). It is well established that there are differences in exercise capacities in the two sexes but how much of that difference reflects on disease severity or correlates to markers of severity in the two sexes is still not clear. Right heart catheterization (RHC) and cardiopulmonary exercise testing (CPET) have been widely used for assessing functional capacity, prognosis and treatment response in IPAH...
January 1, 2017: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/28029703/the-sonographic-stenosis-index-a-new-specific-quantitative-measure-of-transplant-hepatic-arterial-stenosis
#5
Thomas X Le, Daniel S Hippe, Michael F McNeeley, Manjiri K Dighe, Theodore J Dubinsky, Sherwin S Chan
OBJECTIVES: This study evaluates the sensitivity and specificity of stenosis index (SI), which accounts for the entire spectral Doppler waveform, to detect significant transplant hepatic arterial stenosis. MATERIALS AND METHODS: In this institutional review board-approved, HIPAA compliant study, we retrospectively analyzed 69 patients who had catheter angiography for suspected transplant hepatic arterial stenosis (THAS) between January 2006 and December 2010; all patients had Doppler ultrasound within 30 days before angiography...
December 28, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28027757/free-breathing-dynamic-liver-examination-using-a-radial-3d-t1-weighted-gradient-echo-sequence-with-moderate-undersampling-for-patients-with-limited-breath-holding-capacity
#6
Benjamin Kaltenbach, Andrei Roman, Christoph Polkowski, Tatjana Gruber-Rouh, Ralf W Bauer, Renate Hammerstingl, Thomas J Vogl, Stephan Zangos
PURPOSE: To compare free-breathing radial VIBE with moderate undersampling (us-radial-VIBE) with a standard breathhold T1-weighted volumetric interpolated sequence (3D GRE VIBE) in patients unable to suspend respiration during dynamic liver examination. MATERIAL AND METHODS: 23 consecutive patients underwent dynamic liver MR examination using the free-breathing us-radial-VIBE sequence as part of their oncologic follow-up. All patients were eligible for the free-breathing protocol due to severe respiratory artifacts at the planning or precontrast sequences...
January 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28009236/increased-blood-cell-phosphatidylserine-exposure-and-circulating-microparticles-contribute-to-procoagulant-activity-after-carotid-artery-stenting
#7
Lu Zhao, Xiaoming Wu, Yu Si, Zhipeng Yao, Zengxiang Dong, Valerie A Novakovic, Li Guo, Dongxia Tong, He Chen, Yayan Bi, Junjie Kou, Huaizhang Shi, Ye Tian, Shaoshan Hu, Jin Zhou, Jialan Shi
OBJECTIVE Phosphatidylserine (PS) is a major component of the inner leaflet of membrane bilayers. During cell activation or apoptosis, PS is externalized to the outer membrane, providing an important physiological signal necessary for the release of the microparticles (MPs) that are generated through the budding of cellular membranes. MPs express PS and membrane antigens that reflect their cellular origin. PS exposure on the cell surface and the release of MPs provide binding sites for factor Xa and prothrombinase complexes that promote thrombin formation...
December 23, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28000460/sobrepeso-y-obesidad-maternos-como-factores-de-riesgo-independientes-para-que-el-parto-finalice-en-ces%C3%A3-rea
#8
Juan Jesús Fernández Alba, María Del Carmen Paublete Herrera, María Del Carmen González Macías, Florentino Carral San Laureano, Concepción Carnicer Fuentes, Ángel Vilar Sánchez, Rafael Torrejón Cardoso, Luis Javier Moreno Corral
Introducción: el sobrepeso y la obesidad se asocian a una mayor probabilidad de que el parto finalice en cesárea. Dado que dicho incremento del riesgo podría estar sesgado por variables de confusión como la diabetes o la hipertensión, en el presente trabajo pretendemos determinar si este riesgo persiste tras ser ajustado por numerosas variables de control.Objetivo: determinar si el sobrepeso y/o la obesidad son factores de riesgo independientes para que el parto finalice en cesárea.Métodos: estudio de cohortes retrospectivo...
November 29, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28000008/primary-intraventricular-hemorrhage-in-adults-etiological-causes-and-prognostic-factors-in-chinese-population
#9
Si Zhang, Bangsheng Jia, Hao Li, Chao You, Daniel F Hanley, Yan Jiang
Primary intraventricular hemorrhage (PIVH) is a rare type of hemorrhagic stroke that is poorly understood. We aimed to explore the features of this disease in Chinese population via an institutional prospective study. Adult patients diagnosed with PIVH from January 2013 to January 2016 were enrolled in this study. Data, including clinical variables, radiological features, and yield of angiography, were collected to evaluate the clinical features, etiological causes, and prognostic factors of this disease. A total of 67 patients (73...
December 20, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27997586/determination-of-normal-ranges-of-shock-index-and-other-haemodynamic-variables-in-the-immediate-postpartum-period-a-cohort-study
#10
Hannah L Nathan, Kate Cottam, Natasha L Hezelgrave, Paul T Seed, Annette Briley, Susan Bewley, Lucy C Chappell, Andrew H Shennan
OBJECTIVE: To determine the normal ranges of vital signs, including blood pressure (BP), mean arterial pressure (MAP), heart rate (HR) and shock index (SI) (HR/systolic BP), in the immediate postpartum period to inform the development of robust obstetric early warning scores. STUDY DESIGN: We conducted a secondary analysis of a prospective observational cohort study evaluating vital signs collected within one hour following delivery in women with estimated blood loss (EBL) <500ml (316 women) delivering at a UK tertiary centre over a one-year period...
2016: PloS One
https://www.readbyqxmd.com/read/27982160/lifestyle-intervention-on-metabolic-syndrome-and-its-impact-on-quality-of-life-a-randomized-controlled-trial
#11
Patrícia Pozas Saboya, Luiz Carlos Bodanese, Paulo Roberto Zimmermann, Andreia da Silva Gustavo, Fabricio Edler Macagnan, Ana Pandolfo Feoli, Margareth da Silva Oliveira
Background: Lifestyle intervention programs can reduce the prevalence of metabolic syndrome (MetS) and, therefore, reduce the risk for cardiac disease, one of the main public health problems nowadays. Objective: The aim of this study was to compare the effects of three types of approach for lifestyle change programs in the reduction of metabolic parameters, and to identify its impact on the quality of life (QOL) of individuals with MetS. Methods: A randomized controlled trial included 72 individuals with MetS aged 30-59 years...
December 8, 2016: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/27969901/tct-534-fractional-flow-reserve-and-cardiac-events-in-coronary-artery-disease-data-from-prospective-registry
#12
Jung-Min Ahn, Min Soo Cho, Se Hun Kang, Duk-Woo Park, Eun-Seok Shin, Bon-Kwon Koo, Chang-Wook Nam, Joon Hyung Doh, June Hong Kim, In Ho Chae, Junghan Yoon, Sung-Ho Her, Ki-Bae Seung, Woo-Young Chung, Sang-Yong Yoo, Jin Bae Lee, Si Wan Choi, Kyungil Park, TaekJong Hong, Sang Yeub Lee, Pil Hyung Lee, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27941871/nanosomes-carrying-doxorubicin-exhibit-potent-anticancer-activity-against-human-lung-cancer-cells
#13
Akhil Srivastava, Narsireddy Amreddy, Anish Babu, Janani Panneerselvam, Meghna Mehta, Ranganayaki Muralidharan, Allshine Chen, Yan Daniel Zhao, Mohammad Razaq, Natascha Riedinger, Hogyoung Kim, Shaorong Liu, Si Wu, Asim B Abdel-Mageed, Anupama Munshi, Rajagopal Ramesh
Successful chemotherapeutic intervention for management of lung cancer requires an efficient drug delivery system. Gold nanoparticles (GNPs) can incorporate various therapeutics; however, GNPs have limitations as drug carriers. Nano-sized cellular vesicles like exosomes (Exo) can ferry GNP-therapeutic complexes without causing any particle aggregation or immune response. In the present study, we describe the development and testing of a novel Exo-GNP-based therapeutic delivery system -'nanosomes'- for lung cancer therapy...
December 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27913882/early-treatment-response-to-transcatheter-arterial-chemoembolization-is-associated-with-time-to-the-development-of-extrahepatic-metastasis-and-overall-survival-in-intermediate-stage-hepatocellular-carcinoma
#14
Sung Won Lee, Hae Lim Lee, Nam Ik Han, Jeong Won Jang, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon
PURPOSE: Transcatheter arterial chemoembolization (TACE) is the treatment of choice for intermediate-stage hepatocellular carcinoma (HCC). The absence of an early response to TACE might indicate alternative therapeutic strategies early in the course of the disease, thus improving outcomes. Therefore, our purpose was to identify the relationship between treatment response after two sessions of TACE and the time to the development of extrahepatic metastasis and overall survival. METHODS: In total, 108 treatment-naïve intermediate-stage HCC patients who received at least two consecutive sessions of TACE as the first-line treatment were analyzed...
December 2, 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27872983/robotic-assisted-versus-manual-prostatic-arterial-embolization-for-benign-prostatic-hyperplasia-a-comparative-analysis
#15
Sandeep Bagla, John Smirniotopoulos, Julie C Orlando, Rachel Piechowiak
PURPOSE: Prostatic artery embolization (PAE) is a safe and efficacious procedure for benign prostatic hyperplasia (BPH), though is technically challenging. We present our experience of technical and clinical outcomes of robotic and manual PAE in patients with BPH. MATERIALS AND METHODS: IRB-approved retrospective study of 40 consecutive patients 49-81 years old with moderate or severe grade BPH from May 2014 to July 2015: 20 robotic-assisted PAE (group 1), 20 manual PAE (group 2)...
November 21, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27867170/evaluation-of-appropriate-readout-sequence-for-renal-mri-perfusion-using-astar-asl-technique
#16
Kyoko Takakura, Aki Kido, Koji Fujimoto, Kayo Kiguchi, Yasutaka Fushimi, Naotaka Sakashita, Tokunori Kimura, Kaori Togashi
The aim of this study was to compare true-steady state free precession (True-SSFP) with fast field echo (FFE) as readout imaging sequences for renal arterial spin labeling (ASL), and to optimize the imaging condition. Renal ASL perfusion images were acquired using signal targeting with alternated radio frequency using asymmetric inversion slab (ASTAR) technique with respiratory triggering at 3T MRI system, using either 3D True-SSFP or FFE as the readout sequence. Inversion time (TI) varied from 800 to 2400 ms...
2016: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/27866071/the-cd4-cd8-ratio-is-associated-with-coronary-artery-disease-cad-in-elderly-chinese-patients
#17
Pan Gao, Hong-Hui Rong, Ting Lu, Gang Tang, Liang-Yi Si, James A Lederer, Wei Xiong
OBJECTIVE: The aim of this study was to investigate the relationship between number of circulating T cells and coronary artery disease (CAD) in an elderly Chinese population. METHODS: A total of 295 elderly inpatients (age≥60) were included in this cross-sectional study. Their clinical and biochemical characteristics were recorded. Patients were divided to two groups: control patients and CAD patients. The risk factors of CAD were explored by binary logistic regression analysis...
January 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/27857892/arterial-ammonia-levels-prognostic-marker-in-traumatic-hemorrhage
#18
Anurag Singla, Satinder Kaur, Navjot Kaur, C S Gill
BACKGROUND: In blunt trauma, extent of hemorrhage cannot be determined by physical examination, and vital signs may also not give clear picture in all the patients, especially young healthy ones. Hemorrhagic shock has been reported to increase blood ammonia levels. Arterial ammonia was analyzed in blunt trauma abdomen patients and correlated with shock index (SI). Its predictive value was determined for timely decision of intervention. MATERIALS AND METHODS: Hundred blunt trauma abdomen patients presented in the emergency ward of tertiary care hospital were included in the study...
October 2016: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/27807637/clinical-performance-of-antibodies-to-prothrombin-and-thrombin-in-chinese-patients-with-antiphospholipid-syndrome-potential-interest-in-discriminating-patients-with-thrombotic-events-and-non-thrombotic-events
#19
Shulan Zhang, Ziyan Wu, Jing Li, Ping Li, Si Chen, Xiaoting Wen, Liubing Li, Wen Zhang, Jiuliang Zhao, Fengchun Zhang, Yongzhe Li
A hallmark feature of antiphospholipid syndrome (APS) is the presence of a wide spectrum of antiphospholipid antibodies. In this study, we evaluated the clinical relevance of antibodies to prothrombin (PT) (aPT) and thrombin (aThr) in Chinese patients with APS. A total of 229 subjects were tested, including 86 patients with APS [35 patients with primary APS (PAPS), 51 patients with APS associated with other diseases (APSAOD)], 104 patients with non-APS diseases (disease controls), and 39 healthy controls. Serum IgG/IgM/IgA aPT and aThr were determined by ELISA...
November 2, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27800490/resistin-enhances-inflammatory-cytokine-production-in-coronary-artery-tissues-by-activating-the-nf-%C3%AE%C2%BAb-signaling
#20
Fang Gao, Feifei Si, Siqi Feng, Qijian Yi, Ruixi Liu
Purpose. Kawasaki disease (KD) is a systemic vasculitis and is a leading cause of coronary artery lesions (CALs) in childhood. Our previous study has shown higher levels of serum Resistin in KD patients with coronary aneurysm. This study aimed at examining the association of Resistin with inflammatory cytokine expression in mouse model of coronary arteritis and determining the potential mechanisms. Methods. C57BL/6 mice were injected with Lactobacillus cell wall extract (LCWE) to induce coronary arteritis. The relative levels of Resistin, TNF-α, IL-1β, and MMP-9 expression and inflammatory infiltrates in the coronary arteries were determined longitudinally by quantitative RT-PCR, ELISA, and histology...
2016: BioMed Research International
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