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Arterial Si

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https://www.readbyqxmd.com/read/28812311/nad-replenishment-with-nicotinamide-mononucleotide-protects-blood-brain-barrier-integrity-and-attenuates-delayed-tpa-induced-haemorrhagic-transformation-after-cerebral-ischemia
#1
Chun-Chun Wei, Yuan-Yuan Kong, Xia-Hua, Guo-Qiang Li, Si-Li Zheng, Ming-He Cheng, Pei Wang, Chao-Yu Miao
BACKGROUND AND PURPOSE: Tissue plasminogen activator (tPA) is the only approved pharmacological therapy for acute brain ischemia; however, a major limitation of tPA is the haemorrhagic transformation followed by tPA treatment. Here, we determine whether nicotinamide mononucleotide (NMN), a key intermediate of nicotinamide adenine dinucleotide biosynthesis, would affect tPA-induced haemorrhagic transformation. EXPERIMENTAL APPROACH: Middle cerebral artery occlusion (MCAO) was achieved in CD1 mice by introducing a filament to the left MCA for 5 hours...
August 15, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28800959/mybph-inhibits-vascular-smooth-muscle-cell-migration-and-attenuates-neointimal-hyperplasia-in-a-rat-carotid-balloon-injury-model
#2
Ting Zhu, Yi He, Jue Yang, Weiguo Fu, Xin Xu, Yi Si
Vascular smooth muscle cell (VSMC) migration is implicated in restenosis. Myosin binding protein H (MYBPH) is capable of reducing cell motility and metastasis. In this study, we sought to determine whether MYBPH is involved in VSMC migration and neointima formation in response to vascular injury. To determine the expression of MYBPH in injured artery, we used a standard rat carotid artery balloon-injury model. In vivo studies have demonstrated that MYBPH is upregulated after vascular injury. VSMCs treated with platelet-derived growth factor (PDGF)-BB displayed increased MYBPH mRNA and protein levels...
August 8, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28774681/sildenafil-improves-blood-perfusion-in-steroid-induced-avascular-necrosis-of-femoral-head-in-rabbits-via-a-protein-kinase-g-dependent-mechanism
#3
Qichun Song, Jianlong Ni, Hongyuan Jiang, Zhibin Shi
OBJECTIVE: The aim of the study were to evaluate the effect of sildenafil against avascular necrosis of femoral head (ANFH) in a rabbit model, and to study the role of protein kinase G (PKG) pathway and vascular endothelial growth factor (VEGF) in ANFH. METHODS: Three weeks after inducing ANFH with methylprednisolone injection, 45 female adult New Zealand white rabbits were divided into three groups and treated as follows: group SI received daily intraperitoneal sildenafil with a dose of 10 mg/kg per day; group SD received daily sildenafil identically to group SI plus auricular vein injection DT3 (a specific PKG inhibitor); group NS received only normal saline...
July 31, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28770707/pro-fibrotic-effect-of-il-6-via-aortic-adventitial-fibroblasts-indicates-il-6-as-a-treatment-target-in-takayasu-arteritis
#4
Xiufang Kong, Lili Ma, Zongfei Ji, Zhihui Dong, Zhigang Zhang, Jun Hou, Si Zhang, Lingying Ma, Lindi Jiang
OBJECTIVES: This study aimed to clarify potential mechanism of IL-6 involved in adventitial fibrosis via adventitial fibroblast in Takayasu arteritis (TAK). METHODS: Immunohistochemistry and double-labelled immunofluorescence were performed on vascular tissue from patients with TAK and controls. Human aorta adventitial fibroblast (AAF) was cultured and stimulated with interleukine 6 (IL-6)/IL-6 receptor (IL-6R). Real-time PCR, western blot, enzyme-linked immunosorbent assays, chromatin immunoprecipitation (ChIP) and reporter assay were conducted in vitro experiments to determine effect of IL-6/IL-6R on AAF...
July 6, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28769817/suicidal-ideation-is-associated-with-altered-variability-of-fingertip-photo-plethysmogram-signal-in-depressed-patients
#5
Ahsan H Khandoker, Veena Luthra, Yousef Abouallaban, Simanto Saha, Khawza I U Ahmed, Raqibul Mostafa, Nayeefa Chowdhury, Herbert F Jelinek
Physiological and psychological underpinnings of suicidal behavior remain ill-defined and lessen timely diagnostic identification of this subgroup of patients. Arterial stiffness is associated with autonomic dysregulation and may be linked to major depressive disorder (MDD). The aim of this study was to investigate the association between arterial stiffness by photo-plethysmogram (PPG) in MDD with and without suicidal ideation (SI) by applying multiscale tone entropy (T-E) variability analysis. Sixty-one 10-min PPG recordings were analyzed from 29 control, 16 MDD patients with (MDDSI+) and 16 patients without SI (MDDSI-)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28754270/fast-acceleration-of-asl-based-time-resolved-magnetic-resonance-angiography-by-acquisition-of-control-and-labeled-images-in-the-same-shot-fast-actress-an-optimization-study
#6
Hiroyuki Sugimori, Noriyuki Fujima, Yuriko Suzuki, Hiroyuki Hamaguchi, Kinya Ishizaka, Kohsuke Kudo
PURPOSE: To establish an optimized sequence design for fast acceleration of arterial spin labeling (ASL)-based time-resolved magnetic resonance angiography (MRA) by acquisition of control and labeled images in the same shot (fast ACTRESS) and a scan time of <1min, for the evaluation of intracranial vessels. MATERIALS AND METHODS: Ten healthy volunteers with no unilateral symptomatic arterial stenosis, who underwent 3-tesla MRI, were investigated. Imaging parameters for the fast ACTRESS sequence were set with an acquisition time of 45s...
July 25, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28742134/hemostasis-pad-combined-with-compression-device-after-transradial-coronary-procedures-a-randomized-controlled-trial
#7
Si-Hyuck Kang, Donghoon Han, Sehun Kim, Chang-Hwan Yoon, Jin-Joo Park, Jung-Won Suh, Young-Seok Cho, Tae-Jin Youn, In-Ho Chae
BACKGROUND: Arterial access and hemostasis are important processes during percutaneous coronary procedures. In this study, we tested if the use of chitosan-based pads on top of compression devices could improve hemostasis efficacy compared with compression devices alone after transradial coronary angiography or interventions. METHODS: This study was a single-center open-label randomized controlled trial. Patients who underwent coronary angiography or intervention with the transradial approach were randomly assigned to the study (compression device and a chitosan-based pad) or control (compression devices alone) group in a 2:1 fashion...
2017: PloS One
https://www.readbyqxmd.com/read/28740206/relation-between-arterial-stiffness-and-markers-of-inflammation-and-hemostasis-data-from-the-population-based-gutenberg-health-study
#8
Natalie Arnold, Tommaso Gori, Renate B Schnabel, Andreas Schulz, Jürgen H Prochaska, Tanja Zeller, Harald Binder, Norbert Pfeiffer, Manfred Beutel, Christine Espinola-Klein, Karl J Lackner, Stefan Blankenberg, Thomas Münzel, Philipp S Wild
The relation between inflammation, hemostasis and arterial stiffness is of pathophysiological relevance for the development of cardiovascular disease (CVD). Data investigating this interplay using stiffness index (SI) by digital photoplethysmography are not available yet. Therefore, sex-specific relation between SI and inflammatory and hemostatic biomarkers was investigated within 13,724 subjects from the population-based Gutenberg Health Study. C-reactive protein (CRP), white blood cell count (WBCC), neopterin, interleukin-18, interleukin-1 receptor antagonist (IL-1RA), fibrinogen and hematocrit were measured...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28736372/-clinical-value-of-apolipoprotein-b-versus-low-density-lipoprotein-cholesterol-in-assessing-risks-of-coronary-artery-disease
#9
Si Chen, Jin-Zhen Zhao, Jing Hu, Zhi-Gang Guo
OBJECTIVE: To compare the value of apolipoprotein B (apoB) and low-density lipoprotein cholesterol (LDL-C) in assessing the risk of coronary heart disease in patients with inconsistent apoB and LDL-C levels. METHODS: In a total of 603 patients undergoing coronary angiography, apoB and LDL-C levels were categorized into high and low levels relative to the median levels of apoB and LDL-C, based on which the patients were divided into 4 groups with low apoB/low LDL-C, low apoB/high LDL-C, high apoB/low LDL-C, or high apoB/high LDL-C...
July 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28736367/-establishment-of-mouse-model-of-bone-metastasis-of-prostate-cancer-and-breast-cancer-via-femoral-artery-injection-of-tumor-cells
#10
Zhao-Yang Yin, Si-Yong Qi, Xiang Cheng, Liang Guo, Hong-Yu Chen, Ming Shi
OBJECTIVE: To explore an efficient and reliable method for establishing an animal model of bone metastasis of tumors. METHODS: Male C57BL/6J mice were randomized into 4 equal groups to receive injections of normal saline or prostate cancer RM-1 cell suspension via the femoral artery or the external iliac artery, and breast cancer 4T1-luc cells were injected in 15 female BALB/c mice via the femoral artery. The operation time, postoperative survival rate, and the tumor formation rates in the mice with two different injection methods were compared...
July 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28723741/characterization-of-small-%C3%A2-3%C3%A2-cm-hepatic-lesions-with-atypical-enhancement-feature-and-hypointensity-in-hepatobiliary-phase-of-gadoxetic-acid-enhanced-mri-in-cirrhosis-a-stard-compliant-article
#11
Seung Kak Shin, Yun Soo Kim, Seung Joon Choi, Young Sup Shim, Dong Hae Jung, Oh Sang Kwon, Duck Joo Choi, Ju Hyun Kim
It is difficult to characterize the nodular lesions in cirrhotic liver if typical enhancement pattern is not present on dynamic contrast-enhanced imagings. Although the signal intensity of the hepatobiliary phase in gadoxetic acid-enhanced magnetic resonance imaging (MRI) is helpful for characterization of the lesions, some dysplastic nodules may also exhibit low signal intensity in the hepatobiliary phase. We aimed to assess the usefulness of gadoxetic acid (Gd-EOB-DTPA)-enhanced MRI including diffusion-weighted imaging (DWI) for differentiation between atypical small hepatocellular carcinomas (HCCs) and dysplastic nodules showing low signal intensity (SI) in the hepatobiliary phase, and to evaluate the MRI findings in determining the histological grade of atypical HCCs in patients with cirrhosis...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28721149/apolipoprotein-a1-polymorphisms-and-risk-of-coronary-artery-disease-a-meta-analysis
#12
Lang-Biao Xu, Ya-Feng Zhou, Jia-Lu Yao, Si-Jia Sun, Qing Rui, Xiang-Jun Yang, Xiao-Bo Li
INTRODUCTION: It has been reported that APOA1 -75G/A polymorphism might be associated with susceptibility to coronary artery disease (CAD). Owing to mixed and inconclusive results, we conducted a meta-analysis to systematically summarize and clarify the association between APOA1-75G/A polymorphism and the risk of CAD. MATERIAL AND METHODS: A systematic search of studies on the association of single nucleotide polymorphisms (SNP) with susceptibility to CAD was conducted...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28718051/coronary-heart-disease-preoperative-gesture-interactive-diagnostic-system-based-on-augmented-reality
#13
Yi-Bo Zou, Yi-Min Chen, Ming-Ke Gao, Quan Liu, Si-Yu Jiang, Jia-Hui Lu, Chen Huang, Ze-Yu Li, Dian-Hua Zhang
Coronary heart disease preoperative diagnosis plays an important role in the treatment of vascular interventional surgery. Actually, most doctors are used to diagnosing the position of the vascular stenosis and then empirically estimating vascular stenosis by selective coronary angiography images instead of using mouse, keyboard and computer during preoperative diagnosis. The invasive diagnostic modality is short of intuitive and natural interaction and the results are not accurate enough. Aiming at above problems, the coronary heart disease preoperative gesture interactive diagnostic system based on Augmented Reality is proposed...
August 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28715799/resident-arterial-cells-and-circulating-bone-marrow-derived-cells-both-contribute-to-intimal-hyperplasia-in-a-rat-allograft-carotid-transplantation-model
#14
Yi He, Xin Xu, Ting Zhu, Min Tang, Ju Mei, Yi Si
BACKGROUND/AIMS: Neointimal formation following vascular injury remains a major mechanism of restenosis, whereas the precise sources of neointimal cells are still uncertain. We tested the hypothesis that both injured arterial cells and non-arterial cells contribute to intimal hyperplasia. METHODS: Following allograft transplantation of the balloon-injured carotid common artery (n = 3-6), the cellular composition of the transplant grafts and the origins of neointimal cells were measured by immunohistochemistry and immunofluorescence staining...
July 11, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28703883/associations-between-cardiovascular-disease-and-its-risk-factors-with-hearing-loss-a-cross-sectional-analysis
#15
Hsern Ern Ivan Tan, Nick Si Rui Lan, Matthew William Knuiman, Mark Laurence Divitini, De Wet Swanepoel, Michael Hunter, Christopher Gerard Brennan-Jones, Joseph Hung, Robert Henry Eikelboom, Peter Luke Santa Maria
OBJECTIVES: To investigate the relationship between hearing loss and cardiovascular disease risk factors. DESIGN: Cross-sectional study. METHODS: Participants were recruited between May 2010 and December 2015 and answered a health and risk factor questionnaire. Physical and biochemical assessments were performed. SETTING: A community based population. PARTICIPANTS: 5,107 participants born within the years 1946-1964 enrolled in the Busselton Healthy Ageing Study...
July 13, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28690220/-investigation-and-analysis-for-current-situation-and-pathogenesis-relevant-to-pulmonary-hypertension
#16
Si Lei, Doudou Tang, Nianru Xu, Shangjie Wu
To investigate the demographic characteristics and the causes for pulmonary hypertension (PH) in adult patients.
 Methods: A total of 2 508 adult patients diagnosed as PH, who came from the Second Xiangya Hospital of Central South University from January 2010 to December 2014, were retrospectively investigated. All subjects underwent the clinical diagnosis, or the echocardiographic diagnosis, or thetraditional hemodynamic criteria by right heart catheterization (RHC). The patient's data including hospital numbers, gender, ages, primary diseases, etc, are collected and analyzed...
June 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28684904/dysregulation-of-microrna-214-and-pten-contributes-to-the-pathogenesis-of-hypoxic-pulmonary-hypertension
#17
HaiTao Liu, Tao Yin, Wenjun Yan, Rui Si, Bo Wang, Mai Chen, Fei Li, Qiong Wang, Ling Tao
Hypoxia-induced pulmonary hypertension, which is characterized by vascular remodeling of blood vessels, is an important complication in COPD. In this study, we found that the expression of miR-214 was differentially expressed by screening 13 candidate miRNAs in pulmonary artery smooth muscle cells (PASMCs). Additionally, using luciferase assay in PASMCs, we found that phosphatase-and-tensin homolog (PTEN) was a target of miR-214. Furthermore, the expression of PTEN was found to be substantially downregulated in PASMCs from COPD patients with pulmonary hypertension (PH) compared with normal controls by using real-time polymerase chain reaction (PCR), immunohistochemistry, and Western blot...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28684312/up-regulation-of-14-3-3%C3%AE-plays-a-role-in-intimal-hyperplasia-following-carotid-artery-injury-in-diabetic-sprague-dawley-rats-by-promoting-endothelial-cell-migration-and-proliferation
#18
Lishuai Feng, Xu Ma, Jianbo Wang, Qinghua Tian
PURPOSE: The objective of this study was to determine whether diabetes mellitus (DM)-induced up-regulation of 14-3-3β (YWHAB) in endothelial cells enhances intimal hyperplasia in carotid artery-injured DM Sprague-Dawley (SD) rats. METHODS: YWHAB expression and rat aortic endothelial cell (RAOEC) vitality were examined using Cell Counting Kit-8 (CCK-8), quantitative reverse transcription PCR (qRT-PCR), and western blot analysis in cells treated with different glucose concentrations (5...
July 3, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28680577/hypoxia-induced-pulmonary-hypertension-in-type-2-diabetic-mice
#19
Minglin Pan, Ying Han, Rui Si, Rui Guo, Ankit Desai, Ayako Makino
Hypoxia-induced pulmonary hypertension (HPH) is a progressive disease that is mainly caused by chronic exposure to high altitude, chronic obstructive lung disease, and obstructive sleep apnea. The increased pulmonary vascular resistance and increased pulmonary arterial pressure result in increased right ventricular afterload, leading to right heart failure and increased morbidity. There are several clinical reports suggesting a link between PH and diabetes, insulin resistance, or obesity; however, it is unclear whether HPH is associated with diabetes as a progressive complication in diabetes...
March 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28677751/effects-of-rmf-on-bkca-and-kv-channels-in-basilar-arterial-smooth%C3%A2-muscle-cells-of-shr
#20
Yan-Fei Qian, Yang Wang, Wei-Wei Tian, Sheng Wang, Lei Zhao, Li Li, Ke-Tao Ma, Jun-Qiang Si
The current study observed the effects and investigated the mechanism of remifentanil (RMF) on the isolated cerebral basilar arteries of spontaneously hypertensive rats (SHR) and Wistar‑Kyoto (WKY) rats. A pressure myograph system was used to observe and compare the effects of different concentrations of RMF (10‑10‑10‑5 mol/l) on the diameter changes of freshly isolated cerebral basilar arteries, which have been pre‑shrunk by phenylephrine (PE), an endothelium‑independent vasoconstrictor. Vascular smooth‑muscle cells of the cerebral basilar artery (BASMCs) were freshly obtained via enzymolysis...
September 2017: Molecular Medicine Reports
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