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https://www.readbyqxmd.com/read/28526535/tnf-%C3%AE-is-superior-to-conventional-inflammatory-mediators-in-forecasting-ivig-nonresponse-and-coronary-arteritis-in-chinese-children-with-kawasaki-disease
#1
Peng Hu, Guang Mei Jiang, Yue Wu, Bao Yu Huang, Si Yan Liu, Dong Dong Zhang, Yao Xu, Yang Fang Wu, Xun Xia, Wei Wei, Bo Hu
BACKGROUND: Tumor necrosis factor (TNF) -α is of inflammatory cytokines produced chiefly by activated monocyte/macrophages, and has been implicated in the pathogenesis of Kawasaki disease (KD). We elucidated the relationship of plasma TNF-α with conventional inflammatory mediators, clinical classification, intravenous immunoglobulin (IVIG) response and coronary arteritis in the course of KD. METHODS: Seventy Chinese children with KD were enrolled and divided into 6 subgroups, including complete KD, incomplete KD, IVIG-responsive KD, IVIG-nonresponsive KD, coronary artery (CA) -noninvolvement KD and CA-involvement KD...
May 16, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28513236/enhanced-gap-junctional-channel-activity-between-vascular-smooth-muscle-cells-in-cerebral-artery-of-spontaneously-hypertensive-rats
#2
Li-Jie Wang, Ke-Tao Ma, Wen-Yan Shi, Ying-Zi Wang, Lei Zhao, Xin-Yan Chen, Xin-Zhi Li, Xue-Wei Jiang, Zhong-Shuang Zhang, Li Li, Jun-Qiang Si
The aim of the present study is to investigate the effects of hypertension on the gap junctions between vascular smooth muscle cells (VSMCs) in the cerebral arteries (CAs) of spontaneously hypertensive rats (SHRs). The functions of gap junctions in the CAs of VSMCs in SHRs and control normotensive Wistar-Kyoto (WKY) rats were studied using whole-cell patch clamp recordings and pressure myography, and the expression levels of connexins were analyzed using reverse transcription-quantitative polymerase chain reaction and Western blot analyses...
May 17, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28497385/associations-of-human-skeletal-muscle-fiber-type-and-insulin-sensitivity-blood-lipids-and-vascular-hemodynamics-in-a-cohort-of-premenopausal-women
#3
Gordon Fisher, Samuel T Windham, Perry Griffin, Jonathan L Warren, Barbara A Gower, Gary R Hunter
PURPOSE: Cardiometabolic disease remains a leading cause of morbidity and mortality in developed nations. Consequently, identifying and understanding factors associated with underlying pathophysiological processes leading to chronic cardio metabolic conditions is critical. Metabolic health, arterial elasticity, and insulin sensitivity (SI) may impact disease risk, and may be determined in part by myofiber type. Therefore, the purpose of this study was to test the hypothesis that type I myofiber composition would be associated with high SI, greater arterial elasticity, lower blood pressure, and blood lipids; whereas, type IIx myofibers would be associated with lower SI, lower arterial elasticity, higher blood pressure, blood lipids...
May 11, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28481954/minor-defects-of-the-luminal-integrity-in-arterial-introducer-esheaths-after-transcatheter-aortic-valve-implantation
#4
Michael Buege, Till Koehler, Ralf Heiderhoff, Marc Papenheim, Si Wang, Heinrich Schleiting, Wolfgang H Arnold, Jason R Foerst, Melchior Seyfarth, Klaus Tiroch, Thomas Riedl, Marc Vorpahl
BACKGROUND: Medical devices such as implant delivery systems are commonly used during minimally invasive procedures in the cardiovascular system. These devices often have lubricious polymer coatings to reduce friction between the device and blood vessels but coatings may separate and potentially cause serious injuries to patients. METHODS: Lubricious coated eSheaths for transcatheter heart valve implantation were assessed for luminal integrity at the proximal, medial and distal part...
2017: PloS One
https://www.readbyqxmd.com/read/28474207/severity-of-community-acquired-hypernatremia-is-an-independent-predictor-of-mortality
#5
Woo Jin Jung, Hee Jeong Lee, Suyeon Park, Si Nae Lee, Hye Ran Kang, Jin Seok Jeon, Hyunjin Noh, Dong Cheol Han, Soon Hyo Kwon
Hypernatremia develops commonly in critically ill patients during hospitalization, and is associated with adverse outcomes. However, community acquired hypernatremia (CAH) has been rarely studied. We conducted a study in patients who presented to an urban referral hospital, and were admitted with CAH. We retrospectively analyzed patients admitted to an urban tertiary care hospital from January 1, 2012 to December 31, 2014. CAH is defined as more than 147 mEq/L at admission in patients not transferred from other hospitals...
May 4, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28472767/critical-analysis-of-the-major-and-ancillary-imaging-features-of-li-rads-on-127-proven-hccs-evaluated-with-functional-and-morphological-mri-lights-and-shadows
#6
Vincenza Granata, Roberta Fusco, Antonio Avallone, Francesco Filice, Fabiana Tatangelo, Mauro Piccirillo, Roberto Grassi, Francesco Izzo, Antonella Petrillo
PURPOSE: To report a critical analysis of major and ancillary MR imaging features in assessment of HCC. METHODS: Retrospectively we evaluated 70 cirrhotic patients with 173 nodules, which were subjected to MR study at 0 time (MR0), after 3 (MR3) and 6 months (MR6) using two different contrast media. EOB-GD-DTPA was injected at MR0 and MR6, while Gd-BT-DO3A at MR3. Three expert hepatic radiologists reviewed all images, recording, according to LI-RADS, the size, the presence and quality of arterial-phase hyperenhancement, washout and capsule appearance, threshold growth...
April 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28469100/relationship-between-modulator-recognition-factor-2-at-rich-interaction-domain-5b-gene-variations-and-type-2-diabetes-mellitus-or-lipid-metabolism-in-a-northern-chinese-population
#7
Lu-Lu Sun, Si-Jia Zhang, Mei-Jun Chen, Kazakova Elena, Hong Qiao
BACKGROUND: Four single nucleotide polymorphisms (SNPs) in the modulator recognition factor 2/AT-rich interaction domain 5B (MRF2/ARID5B) gene located at chromosome 10q21.2 have been shown to be associated with both type 2 diabetes mellitus (T2DM) and coronary artery disease in a Japanese cohort. This study aimed to investigate the relationship between these SNPs (rs2893880, rs10740055, rs7087507, rs10761600) and new-onset T2DM and lipid metabolism in a Northern Chinese population. METHODS: This was a case-control study...
May 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28465003/the-modified-rapid-emergency-medicine-score-a-novel-trauma-triage-tool-to-predict-in-hospital-mortality
#8
Ross T Miller, Niaman Nazir, Tracy McDonald, Chad M Cannon
BACKGROUND: Trauma systems currently rely on imperfect and subjective tools to prioritize responses and resources, thus there is a critical need to develop a more accurate trauma severity score. Our objective was to modify the Rapid Emergency Medicine (REMS) Score for the trauma population and test its accuracy as a predictor of in-hospital mortality when compared to other currently used scores, including the Revised Trauma Score (RTS), the Injury Severity Score (ISS), the "Mechanism, Glasgow Coma Scale, Age and Arterial Pressure" (MGAP) score, and the Shock Index (SI) score...
April 25, 2017: Injury
https://www.readbyqxmd.com/read/28419949/characteristics-of-seizure-induced-signal-changes-on-mri-in-patients-with-first-seizures
#9
Si Eun Kim, Byung In Lee, Kyong Jin Shin, Sam Yeol Ha, JinSe Park, Kang Min Park, Hyung Chan Kim, Joonwon Lee, Soo-Young Bae, Dongah Lee, Sung Eun Kim
PURPOSE: The aim of this study was to investigate the predictive factors and identify the characteristics of the seizure-induced signal changes on MRI (SCM) in patients with first seizures. METHODS: We conducted a retrospective study of patients with first seizures from March 2010 to August 2014. The inclusion criteria for this study were patients with 1) first seizures, and 2) MRI and EEG performed within 24h of the first seizures. The definition of SCM was hyper-intensities in the brain not applying to cerebral arterial territories...
April 11, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28418840/distinct-mdct-imaging-features-to-differential-diagnosis-of-hepatic-paragonimiasis-and-small-hepatocellular-carcinoma
#10
Sheng Zhang, Si-Ming Xie, Yong-Hua Chen, Xu-Bao Liu, Gang Mai
We used multi-row detector computed tomography (MDCT) to identify the distinguishing characteristics of hepatic paragonimiasis and small hepatocellular carcinoma lesions. We analyzed a cohort of 60 patients, of which 26 had hepatic paragonimiasis and 34 with a small (≤ 3cm) hepatocellular carcinoma. MDCT detected 65 lesions that were retrospectively reviewed and analyzed based on their imaging features. Both groups showed distinct MDCT imaging features that could contribute to an accurate diagnosis. In the paragonimiasis group, 75% (21/28) lesions were located in the hepatic subcapsular region, whereas only 10...
March 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28402958/thalidomide-combined-with-thanscatheter-artierial-chemoembolzation-for-primary-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#11
REVIEW
De-Dong Cao, Hui-Lin Xu, Liang Liu, Yong-Fa Zheng, Si-Fa Gao, Xi-Ming Xu, Wei Ge
OBJECTIVE: Transcatheter arterial chemoembolization (TACE) and thalidomide have been used for treating primary hepatocellular carcinoma(HCC). This study aims to evaluate the clinical efficacy and safety of thalidomide and TACE in primary HCC. METHODS: Randomized controlled trials(RCTs) about efficacy and safety of thalidomide combined with TACE for primary HCC were identified from the Cochrane Library, Pubmed, Embase, CNKI, and Wan Fang until August, 2016. The retrieved trials were reviewed and the data were extracted by two reviewers, independently...
March 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28401995/orthostatic-dizziness-in-parkinson-s-disease-is-attributed-to-cerebral-hypoperfusion-a-transcranial-doppler-study
#12
Jinse Park, Hee-Tae Kim, Kang Min Park, Sam Yeol Ha, Sung Eun Kim, Kyong Jin Shin, Si Eun Kim, Wooyoung Jang, Ji Sun Kim, Jinyoung Youn, Engsoek Oh, Suyeon Park
OBJECTIVES: Orthostatic hypotension (OH) is controversially regarded as the cause of orthostatic dizziness in Parkinson's disease (PD). We sought to evaluate whether cerebral autoregulation is an alternative cause for orthostatic dizziness in PD patients, using transcranial Doppler monitoring during head-up tilting. METHODS: Forty-five PD patients with dizziness, 13 PD patients without dizziness, and 10 age-matched healthy controls were enrolled. Participants were divided into the following four groups: patients with dizziness and OH (group 1, n = 22), patients with dizziness but no OH (n = 23, group 2), patients without dizziness (n = 11, group 3), and age-matched healthy controls (n = 10, group 4)...
April 12, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28391913/clinical-and-economic-consequences-of-statin-intolerance-in-the-united-states-results-from-an-integrated-health-system
#13
Jove H Graham, Robert J Sanchez, Joseph J Saseen, Usha G Mallya, Mary P Panaccio, Michael A Evans
BACKGROUND: Although statins are considered safe and effective, they have been associated with statin intolerance (SI) in clinical and observational studies. OBJECTIVE: The objective of this study was to describe the clinical and economic consequences of SI through comparison of an SI cohort of patients with matched controls. METHODS: This study used data extracted from an integrated health system's electronic health records from 2008 to 2014...
January 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28371277/overexpression-of-microrna-138-alleviates-human-coronary-artery-endothelial-cell-injury-and-inflammatory-response-by-inhibiting-the-pi3k-akt-enos-pathway
#14
Jing-Bo Li, Hai-Yang Wang, Ye Yao, Qing-Feng Sun, Zong-Hong Liu, Si-Qi Liu, Jun-Li Zhuang, Yun-Peng Wang, Hong-Yu Liu
This study aimed to investigate the role of miR-138 in human coronary artery endothelial cell (HCAEC) injury and inflammatory response and the involvement of the PI3K/Akt/eNOS signalling pathway. Oxidized low-density lipoprotein (OX-LDL)-induced HCAEC injury models were established and assigned to blank, miR-138 mimic, miR-138 inhibitor, LY294002 (an inhibitor of the PI3K/Akt/eNOS pathway), miR-138 inhibitor + LY294002 and negative control (NC) groups. qRT-PCR and Western blotting were performed to detect the miR-138, PI3K, Akt and eNOS levels and the protein expressions of PI3K, Akt, eNOS, p-Akt, p-eNOS, Bcl-2, Bax and caspase-3...
March 31, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28359507/a-novel-arterial-cannulation-technique-for-selective-regional-cerebral-perfusion
#15
Hyungtae Kim, Si Chan Sung, Kwang Ho Choi
A selective regional cerebral perfusion has been widely adopted for brain protection in neonatal or infant aortic arch surgeries. The anastomosis of the small polytetrafluoroethylene tube graft to the innominate artery has been used for the selective regional cerebral perfusion in many institutions. We have developed a specially designed cannula tip that allows bidirectional blood flow and provides secure positioning of the polytetrafluoroethylene tube graft at the innominate artery. Innominate artery cannulation using this device reduces arterial clamping time and permits us to perform the arterial cannulation in a much easier and secure manner...
April 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28356440/fractional-flow-reserve-and-cardiac-events-in-coronary-artery-disease-data-from-a-prospective-registry
#16
Jung-Min Ahn, Duk-Woo Park, Eun-Seok Shin, Bon-Kwon Koo, Chang-Wook Nam, Joon-Hyung Doh, June Hong Kim, In-Ho Chae, Jung-Han Yoon, Sung-Ho Her, Ki-Bae Seung, Woo-Young Chung, Sang-Yong Yoo, Jin Bae Lee, Si Wan Choi, Kyungil Park, Taek Jong Hong, Sang Yeub Lee, Minkyu Han, Pil Hyung Lee, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park
Background -We evaluated the prognosis of deferred and revascularized coronary stenoses after FFR measurement to assess its revascularization threshold in clinical practice. Methods -The IRIS-FFR registry prospectively enrolled 5846 patients with at least one coronary lesion with FFR measurement. Revascularization was deferred in 6468 lesions and performed in 2165 lesions after FFR assessment. The primary endpoint was major adverse cardiac events (MACE; cardiac death, myocardial infarction, and repeat revascularization) at a median follow-up of 1...
March 29, 2017: Circulation
https://www.readbyqxmd.com/read/28335897/mitral-loop-cerclage-annuloplasty-for-secondary-mitral-regurgitation-first-human-results
#17
Yong-Hyun Park, Min-Ku Chon, Robert J Lederman, Si-Chan Sung, Hyung-Gon Je, Ki-Seok Choo, Sang-Hyun Lee, Eun-Seok Shin, Jeong-Su Kim, Ki-Won Hwang, Soo-Yong Lee, Kook-Jin Chun, Cheol-Min Kim, June-Hong Kim
OBJECTIVES: This is an early feasibility clinical test of mitral loop cerclage annuloplasty to treat secondary mitral valve regurgitation. BACKGROUND: Secondary mitral regurgitation is characterized by cardiomyopathy, mitral annular enlargement, and leaflet traction contributing to malcoaptation. Transcatheter mitral loop cerclage applies circumferential compression to the mitral annulus by creating a loop through the coronary sinus across the interventricular septum, protecting entrapped coronary arteries from compression, and interactive annular reduction under echocardiographic guidance...
March 27, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28303441/association-between-health-literacy-and-hypertension-management-in-a-chinese-community-a-retrospective-cohort-study
#18
Di Shi, Jiangbo Li, Yong Wang, Si Wang, Kai Liu, Rufeng Shi, Qiang Zhang, Xiaoping Chen
Low health literacy is associated with poor clinical outcomes. The relationship between literacy and blood pressure (BP) has been inconsistent. We investigated the determinants of health literacy and the potential relationship between health literacy and hypertension management. We conducted a retrospective cohort trial of 360 hypertensive patients. Scale measurements, physical examination, and laboratory tests were performed based on a standard protocol. To determine factors associated with health literacy, multiple logistic regression analysis was performed and the discriminatory power of the scale score for hypertension control was assessed by the area under the receiver operating curve...
March 16, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28289242/acupuncture-attenuated-vascular-dementia-induced-hippocampal-long-term-potentiation-impairments-via-activation-of-d1-d5-receptors
#19
Yang Ye, Hui Li, Jing-Wen Yang, Xue-Rui Wang, Guang-Xia Shi, Chao-Qun Yan, Si-Ming Ma, Wen Zhu, Qian-Qian Li, Tian-Ran Li, Ling-Yong Xiao, Cun-Zhi Liu
BACKGROUND AND PURPOSE: Emerging evidence suggests that acupuncture could improve cognitive impairment in vascular dementia by enhancing synaptic plasticity in the hippocampus. The purpose of this study is to investigate whether dopamine, a key mediator of synaptic plasticity, is involved in this cognitive improvement. METHODS: Vascular dementia model was established by bilateral common carotid arteries occlusion in male Wistar rats. Three days after the operation, animals received acupuncture treatment for 2 weeks, once daily...
April 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28272236/association-of-cyp2j2-gene-polymorphisms-with-ischemic-stroke-and-stroke-subtypes-in-chinese-population
#20
Si-Yang Wang, Peng-Fei Xing, Chun-Yang Zhang, Ben-Qiang Deng
BACKGROUND AND PURPOSE: Ischemic stroke (IS) is the main cause of mortality and disability among the old people in China and is a multifactorial disease influenced by many factors including genetic factors like the allele for CYP 2J2. It has been demonstrated that CYP2J2 polymorphisms alter the transcriptional activity. However, studies on the association between CYP2J2-50G/T polymorphism and IS have reported conflicting results. Thus, our study aimed to examine the association between 4 variants in the CYP2J2 gene and the risk of IS and its subtypes, in the Chinese population...
March 2017: Medicine (Baltimore)
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