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https://www.readbyqxmd.com/read/29245146/effects-of-elevated-o3-on-physiological-and-biochemical-responses-in-three-kinds-of-trees-native-to-subtropical-forest-in-china-during-non-growing-period
#1
Hao Yu, Jixin Cao, Zhan Chen, He Shang
Numerous studies have documented the negative effects of ozone (O3) on tree species in growing season, however, little is done in non-growing season. Three evergreen tree species, Phoebe bournei (Hemsl.) Yang (P. bournei), Machilus pauhoi Kanehira (M. pauhoi) and Taxus chinensis (Pilger) Rehd (T. chinensis), were exposed to non-filtered air, 100 nmol mol-1 O3 air (E1) and 150 nmol mol-1 O3 air (E2) in open-top chambers in subtropical China. In the entire period of experiment, O3 fumigation decreased net photosynthesis rate (Pn) through stomatal limitation during the transition period from growing to non-growing season (TGN), and through non-stomatal limitation during the period of non-growing season (NGS) in all species tested...
December 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29245126/geographic-and-social-disparities-in-exposure-to-air-neurotoxicants-at-u-s-public-schools
#2
Sara E Grineski, Timothy W Collins
Children are especially vulnerable to the health and developmental impacts of environmental hazards and they spend significant portions of their days at school. Yet there are no national-level studies examining school-level environmental inequalities and few have examined disparate exposure to neurological air toxicants, even though chronic exposure to air pollution impacts children's brain functioning. We paired information about the geographic locations and demographics of each public school in the US with air neurotoxicant exposure estimates pertaining to 24 known neurotoxicants included in the US Environmental Protection Agency's National Air Toxics Assessment...
December 12, 2017: Environmental Research
https://www.readbyqxmd.com/read/29244943/electrical-programming-of-soft-matter-using-temporally-varying-electrical-inputs-to-spatially-control-self-assembly
#3
Kun Yan, Yi Liu, Jitao Zhang, Santiago O Correa, Wu Shang, Cheng-Chieh Tsai, William E Bentley, Jana Shen, Giuliano Scarcelli, Christopher B Raub, Xiao-Wen Shi, Gregory F Payne
The growing importance of hydrogels in translational medicine has stimulated the development of top-down fabrication methods, yet often these methods lack the capabilities to generate the complex matrix architectures observed in biology. Here we show that temporally varying electrical signals can cue a self-assembling polysaccharide to controllably form a hydrogel with complex internal patterns. Evidence from theory and experiment indicate that internal structure emerges through a subtle interplay between: the electrical current which triggers self-assembly; and the electrical potential (or electric field) which recruits and appears to orient the polysaccharide chains at the growing gel front...
December 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29244813/a-different-view-on-the-necker-cube-differences-in-multistable-perception-dynamics-between-asperger-and-non-asperger-observers
#4
Jürgen Kornmeier, Rike Wörner, Andreas Riedel, Ludger Tebartz van Elst
BACKGROUND: During observation of the Necker cube perception becomes unstable and alternates repeatedly between a from-above-perspective ("fap") and a from-below-perspective ("fbp") interpretation. Both interpretations are physically equally plausible, however, observers usually show an a priori top-down bias in favor of the fap interpretation. Patients with Autism spectrum disorder are known to show an altered pattern of perception with a focus on sensory details. In the present study we tested whether this altered perceptual processing affects their reversal dynamics and reduces the perceptual bias during Necker cube observation...
2017: PloS One
https://www.readbyqxmd.com/read/29244655/duplex-imprinted-nano-well-arrays-for-promising-nanoparticles-assembly
#5
Xiangping Li, Andreas Manz
A large area nano-duplex-imprint technique is presented in this contribution using natural cicada wings as stamp. The glassy wings of the cicada, which are abundant in nature, exhibit strikingly interesting nanopillar structures over their membrane. This technique, with excellent performance despite the nonplanar surface of the wings, combines the top-down and bottom-up nanofabrication techniques. It transits micro-nanofabrication from cleanroom environment to bench. Two different materials - dicing tape with acrylic layer and UV optical adhesive - are used to make replications at the same time, thus achieving duplex imprint...
December 15, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29244636/event-related-electroencephalographic-lateralizations-mark-individual-differences-in-spatial-and-nonspatial-visual-selection
#6
Iris Wiegand, Natan Napiorkowski, Thomas Töllner, Anders Petersen, Thomas Habekost, Hermann J Müller, Kathrin Finke
Selective attention controls the distribution of our visual system's limited processing resources to stimuli in the visual field. Two independent parameters of visual selection can be quantified by modeling an individual's performance in a partial-report task based on the computational theory of visual attention (TVA): (i) top-down control α, the relative attentional weighting of relevant over irrelevant stimuli, and (ii) spatial bias wλ, the relative attentional weighting of stimuli in the left versus right hemifield...
December 15, 2017: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/29244202/mental-health-risk-adjustment-with-clinical-categories-and-machine-learning
#7
Akritee Shrestha, Savannah Bergquist, Ellen Montz, Sherri Rose
OBJECTIVE: To propose nonparametric ensemble machine learning for mental health and substance use disorders (MHSUD) spending risk adjustment formulas, including considering Clinical Classification Software (CCS) categories as diagnostic covariates over the commonly used Hierarchical Condition Category (HCC) system. DATA SOURCES: 2012-2013 Truven MarketScan database. STUDY DESIGN: We implement 21 algorithms to predict MHSUD spending, as well as a weighted combination of these algorithms called super learning...
December 15, 2017: Health Services Research
https://www.readbyqxmd.com/read/29244122/la-related-protein-1-larp1-repression-of-top-mrna-translation-is-mediated-through-its-cap-binding-domain-and-controlled-by-an-adjacent-regulatory-region
#8
Lucas Philippe, Jean-Jacques Vasseur, Françoise Debart, Carson C Thoreen
Cell growth is a complex process shaped by extensive and coordinated changes in gene expression. Among these is the tightly regulated translation of a family of growth-related mRNAs defined by a 5' terminal oligopyrimidine (TOP) motif. TOP mRNA translation is partly controlled via the eukaryotic initiation factor 4F (eIF4F), a translation factor that recognizes the mRNA 5' cap structure. Recent studies have also implicated La-related protein 1 (LARP1), which competes with eIF4F for binding to mRNA 5' ends. However, it has remained controversial whether LARP1 represses TOP mRNA translation directly and, if so, what features define its mRNA targets...
December 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29244075/the-athlete-s-heart-is-a-proarrhythmic-heart-and-what-that-means-for-clinical-decision-making
#9
Hein Heidbuchel
Recurring questions when dealing with arrhythmias in athletes are about the cause of the arrhythmia and, more importantly, about the eligibility of the athlete to continue sports activities. In essence, the relation between sports and arrhythmias can be understood along three lines: sports as arrhythmia trigger on top of an underlying problem, sports as arrhythmic substrate promotor, or sports as substrate inducer. Often, there is no sharp divider line between these entities. The athlete's heart, a heart that adapts so magically to cope with the demands of exercise, harbours many structural and functional changes that by themselves predispose to arrhythmia development, at the atrial, nodal and ventricular levels...
December 13, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29244030/static-response-of-deformable-microchannels-a-comparative-modelling-study
#10
Tanmay C Shidhore, Ivan C Christov
We present a comparative modelling study of fluid--structure interactions in microchannels. Through a mathematical analysis based on plate theory and the lubrication approximation for low-Reynolds-number flow, we derive models for the flow rate--pressure drop relation for long shallow microchannels with both thin and thick deformable top walls. These relations are tested against full three-dimensional two-way-coupled fluid--structure interaction simulations. Three types of microchannels, representing different elasticity regimes and having been experimentally characterized previously, are chosen as benchmarks for our theory and simulations...
December 15, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29244002/higher-recall-in-metagenomic-sequence-classification-exploiting-overlapping-reads
#11
Samuele Girotto, Matteo Comin, Cinzia Pizzi
BACKGROUND: In recent years several different fields, such as ecology, medicine and microbiology, have experienced an unprecedented development due to the possibility of direct sequencing of microbioimic samples. Among problems that researchers in the field have to deal with, taxonomic classification of metagenomic reads is one of the most challenging. State of the art methods classify single reads with almost 100% precision. However, very often, the performance in terms of recall falls at about 50%...
December 6, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29243930/structure-based-kinase-profiling-to-understand-the-polypharmacological-behavior-of-therapeutic-molecules
#12
Devawati Dutta, Ranjita Das, Chhabinath Mandal, Chitra Mandal
Several drugs elicit their therapeutic efficacy by modulating multiple cellular targets and possess varied polypharmacological actions. The identification of the molecular targets of a potent bioactive molecule is essential in determining its overall polypharmacological profile. Experimental procedures are expensive and time-consuming. Therefore, computational approaches are actively implemented in rational drug discovery. Here, we demonstrate a computational pipeline, based on reverse virtual screening technique using several consensus scoring strategies, and perform structure-based kinase profiling of 12 FDA-approved drugs...
December 15, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29243908/thin-film-nanocomposite-membrane-with-the-minimum-amount-of-mof-by-the-langmuir-schaefer-technique-for-nanofiltration
#13
Marta Navarro, Javier Benito, Lorena Paseta, Ignacio Gascón, Joaquin Coronas, Carlos Téllez
An innovative procedure for positioning a monolayer of hydrophilic metal-organic framework (MOF) MIL-101(Cr) nanoparticles (NPs) in thin film nanocomposite (TFN) membranes has been implemented by transferring a Langmuir-Schaefer (LS) film of the MOF in between the polyamide thin layer at the top and the cross-linked asymmetric polyimide (P84®) support at the bottom. The presence and layout of the LS-MIL-101(Cr) monolayer in the TFN membrane was confirmed by STEM-HAADF images, and XPS, EDS, EELS and AFM analysis...
December 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29243215/identification-of-banana-lectin-isoforms-and-differential-acetylation-through-mass-spectrometry-approaches
#14
B S Gnanesh Kumar, Avadhesha Surolia
Banana lectin (BanLec) exhibits specificity to glucose/mannose residues present in oligo saccharides or glycoconjugates and has attracted a lot of attention recently as a potent therapeutic agent. Structural studies and molecular cloning methods has revealed the presence of three different BanLec proteins in two species. In our study, initial mass spectrometric analysis of affinity purified native BanLec from banana pulp (Musa paradisiaca) indicated the presence of proteins with different molecular mass. Through the bottom up and top down analysis we identified three major isoforms with acetylation at N terminus...
December 14, 2017: Protein Journal
https://www.readbyqxmd.com/read/29243155/trends-in-plant-research-using-molecular-markers
#15
REVIEW
Jose Antonio Garrido-Cardenas, Concepción Mesa-Valle, Francisco Manzano-Agugliaro
A deep bibliometric analysis has been carried out, obtaining valuable parameters that facilitate the understanding around the research in plant using molecular markers. The evolution of the improvement in the field of agronomy is fundamental for its adaptation to the new exigencies that the current world context raises. In addition, within these improvements, this article focuses on those related to the biotechnology sector. More specifically, the use of DNA markers that allow the researcher to know the set of genes associated with a particular quantitative trait or QTL...
December 14, 2017: Planta
https://www.readbyqxmd.com/read/29242971/effects-of-hydration-on-plasma-copeptin-glycemia-and-gluco-regulatory-hormones-a-water-intervention-in-humans
#16
Sofia Enhörning, Irina Tasevska, Ronan Roussel, Nadine Bouby, Margaretha Persson, Philippe Burri, Lise Bankir, Olle Melander
PURPOSE: High plasma copeptin, a marker of vasopressin, predicts diabetes mellitus. We tested if copeptin could be suppressed by increased water intake in healthy individuals, and if a water-induced change in copeptin was accompanied by altered concentrations of glucose, insulin or glucagon. METHODS: Thirty-nine healthy individuals underwent, in random order, 1 week of high water intake (3 L/day on top of habitual intake) and 1 week of normal (habitual) fluid intake (control)...
December 14, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29242952/unicortical-self-drilling-external-fixator-pins-reduce-thermal-effects-during-pin-insertion
#17
Markus Greinwald, Patrick A Varady, Peter Augat
INTRODUCTION: External fixation is associated with the risk of pin loosening and pin infection potentially associated to thermal bone necrosis during pin insertion. OBJECTIVE: This study aims to investigate if the use of external fixator systems with unicortical pins reduces the heat production during pin insertion compared to fixators with bicortical pins. METHODS: Porcine bone specimens were employed to determine bone temperatures during insertion of fixator pins...
December 14, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29242752/out-of-pocket-expenditures-for-prevention-and-treatment-of-cardiovascular-disease-in-general-and-specialised-cardiac-hospitals-in-addis-ababa-ethiopia-a-cross-sectional-cohort-study
#18
Mieraf Taddesse Tolla, Ole Frithjof Norheim, Stéphane Verguet, Abebe Bekele, Kassahun Amenu, Senbeta Guteta Abdisa, Kjell Arne Johansson
Background: Cardiovascular disease poses a great financial risk on households in countries without universal health coverage like Ethiopia. This paper aims to estimate the magnitude and intensity of catastrophic health expenditure and factors associated with catastrophic health expenditure for prevention and treatment of cardiovascular disease in general and specialised cardiac hospitals in Addis Ababa. Methods and findings: We conducted a cross-sectional cohort study among individuals who sought cardiovascular disease care in selected hospitals in Addis Ababa during February to March 2015 (n=589, response rate 94%)...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29242189/secreted-heme-peroxidase-from-dictyostelium-discoideum-insights-into-catalysis-structure-and-biological-role
#19
Andrea Nicolussi, Joe Dan Dunn, Georg Mlynek, Marzia Bellei, Marcel Zámocký, Gianantonio Battistuzzi, Kristina Djinovic-Carugo, Paul G Furtmüller, Thierry Soldati, Christian Obinger
Oxidation of halides and thiocyanate by heme peroxidases to antimicrobial oxidants is an important cornerstone in the innate immune system of mammals. Interestingly, phylogenetic and physiological studies suggest that homologous peroxidases are already present in mycetozoan eukaryotes such as Dictyostelium discoideum This social amoeba kills bacteria via phagocytosis for nutrient acquisition at its single-cell stage and for antibacterial defense at its multicellular stages. Here we demonstrate that peroxidase A from D...
December 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29241959/the-journal-of-pediatric-surgery-its-first-50-years
#20
REVIEW
George W Holcomb
This article is based on the Journal of Pediatric Surgery Lecture at the 2017 meeting of the British Association of Pediatric Surgeons. This lecture was renamed The Jay L. Grosfeld /Journal of Pediatric Surgery Lecture in honor of Dr. Jay L. Grosfeld who was Editor-in-Chief of the Journal of Pediatric Surgery (JPS) from 1994 until his passing in 2016. The first part of this paper recounts the first 50years of JPS starting with the efforts of Drs. Koop and Gans to start a Journal devoted to Pediatric Surgery...
November 12, 2017: Journal of Pediatric Surgery
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