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https://www.readbyqxmd.com/read/29677603/the-comparative-evidence-basis-for-the-efficacy-of-second-generation-antidepressants-in-the-treatment-of-depression-in-the-us-a-bayesian-meta-analysis-of-food-and-drug-administration-reviews
#1
Rei Monden, Annelieke M Roest, Don van Ravenzwaaij, Eric-Jan Wagenmakers, Richard Morey, Klaas J Wardenaar, Peter de Jonge
BACKGROUND: Studies have shown similar efficacy of different antidepressants in the treatment of depression. METHOD: Data of phase-2 and -3 clinical-trials for 16 antidepressants (levomilnacipran, desvenlafaxine, duloxetine, venlafaxine, paroxetine, escitalopram, vortioxetine, mirtazapine, venlafaxine XR, sertraline, fluoxetine, citalopram, paroxetine CR, nefazodone, bupropion, vilazodone), approved by the FDA for the treatment of depression between 1987 and 2016, were extracted from the FDA reviews that were used to evaluate efficacy prior to marketing approval, which are less liable to reporting biases...
April 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29677445/new-amphiphilic-composite-for-preparing-efficient-coated-potassium-fertilizers-for-top-dressing-fertilization-of-annual-crops
#2
Oscar Urrutia, Javier Erro, Andre Vinicius Zabini, Kent Hoshiba, Anne Francoise Blandin, Roberto Baigorri, Manuel Martin-Pastor, Yves Alis, Jean-Claude Yvin, José María García-Mina
This study describes the efficiency of a new coating material for preparing granulated potassium-fertilizers with a potassium release to the soil solution sensitive to rainfall intensity. The composite is prepared by reaction of an alkyd-resin with cement in the absence of water. The complementary use of diverse analytical techniques showed that the presence of the cement fraction induced alkyd resin reticulation and gradual cement-resin hardening. Scanning electron microscopy revealed the formation of micro and nanopores within cement-clusters, whose water permeability is affected by the resin reticulation and amphiphilic character...
April 20, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29677325/continuous-flash-suppression-manual-action-affects-eye-movements-but-not-the-reported-percept
#3
Peter Veto, Immo Schütz, Wolfgang Einhäuser
Diverse paradigms, including ambiguous stimuli and mental imagery, have suggested a shared representation between motor and perceptual domains. We examined the effects of manual action on ambiguous perception in a continuous flash suppression (CFS) experiment. Specifically, we asked participants to try to perceive a suppressed grating while rotating a manipulandum. In one condition, the grating's motion was fully controlled by the manipulandum movement; in another condition the coupling was weak; and in a third condition, no movement was executed...
March 1, 2018: Journal of Vision
https://www.readbyqxmd.com/read/29677185/patterning-mechanisms-diversify-neuroepithelial-domains-in-the-drosophila-optic-placode
#4
Abhishek Kumar Mishra, F Javier Bernardo-Garcia, Cornelia Fritsch, Tim-Henning Humberg, Boris Egger, Simon G Sprecher
The central nervous system develops from monolayered neuroepithelial sheets. In a first step patterning mechanisms subdivide the seemingly uniform epithelia into domains allowing an increase of neuronal diversity in a tightly controlled spatial and temporal manner. In Drosophila, neuroepithelial patterning of the embryonic optic placode gives rise to the larval eye primordium, consisting of two photoreceptor (PR) precursor types (primary and secondary), as well as the optic lobe primordium, which during larval and pupal stages develops into the prominent optic ganglia...
April 20, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29677034/functional-somatic-symptoms-across-cultures-perceptual-and-health-care-issues
#5
Bernd Löwe, Christian Gerloff
Functional neurological disorders are conceptualized as patterns of neurological symptoms that cannot be attributed to a clear organic etiology. The study by Wilkins et al. published in this issue of Psychosomatic Medicine, revealed that 8.2% of patients who were initially presented with suspected stroke were later diagnosed with functional disorders, i.e., "functional stroke mimics." However, the percentage of functional stroke mimics varied substantially with patients' nationality, age, and sex...
April 19, 2018: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29676965/the-influence-of-wind-speed-on-airflow-and-fine-particle-transport-within-different-building-layouts-of-an-industrial-city
#6
Dan Mei, Meng Wen, Yuzheng Zhu, Xuemei Xu, Futang Xing
In atmospheric environment, the layout difference of urban buildings has a powerful influence on accelerating or inhibiting the dispersion of particle matters (PM). In industrial cities, buildings of variable heights can obstruct the diffusion of PM from industrial stacks. In this study, PM dispersed within building groups was simulated by Reynolds-averaged Navier-Stokes equations coupled Lagrangian approach. Four typical street building arrangements were used: (a) a low-rise building block with Height/base H/b = 1 (b = 20 m); (b) step-up building layout (H/b = 1, 2, 3, 4); (c) step-down building layout (H/b = 4, 3, 2, 1); (d) high-rise building block (H/b = 5)...
April 20, 2018: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/29676907/%C3%AE-glucocerebrosidase-modulators-promote-dimerization-of-%C3%AE-glucocerebrosidase-and-reveal-an-allosteric-binding-site
#7
Jianbin Zheng, Long Chen, Owen S Skinner, Daniel Ysselstein, Jonathan Remis, Peter Lansbury, Renato Skerlj, Michael Mrosek, Ursula Heunisch, Stephan Krapp, Joel Charrow, Michael Schwake, Neil L Kelleher, Richard B Silverman, Dimitri Krainc
β-Glucocerebrosidase (GCase) mutations cause Gaucher's disease and are a high risk factor in Parkinson's disease. The implementation of a small molecule modulator is a strategy to restore proper folding and lysosome delivery of degradation-prone mutant GCase. Here, we present a potent quinazoline modulator, JZ-4109, which stabilizes wild-type and N370S mutant GCase and increases GCase abundance in patient-derived fibroblast cells. We then developed a covalent modification strategy using a lysine targeted inactivator (JZ-5029) for in vitro mechanistic studies...
April 20, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29676861/spatial-processes-decouple-management-from-objectives-in-a-heterogeneous-landscape-predator-control-as-a-case-study
#8
Peter J Mahoney, Julie K Young, Kent R Hersey, Randy T Larsen, Brock R McMillan, David C Stoner
Predator control is often implemented with the intent of disrupting top-down regulation in sensitive prey populations. However, ambiguity surrounding the efficacy of predator management, as well as the strength of top-down effects of predators in general, is often exacerbated by the spatially implicit analytical approaches used in assessing data with explicit spatial structure. Here, we highlight the importance of considering spatial context in the case of a predator control study in south-central Utah. We assessed the spatial match between aerial removal risk in coyotes (Canis latrans) and mule deer (Odocoileus hemionus) resource selection during parturition using a spatially explicit, multi-level Bayesian model...
April 2018: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/29676844/differentiation-of-brain-infection-from-necrotic-glioblastoma-using-combined-analysis-of-diffusion-and-perfusion-mri
#9
Sanjeev Chawla, Sumei Wang, Suyash Mohan, MacLean Nasrallah, Gaurav Verma, Steven Brem, Donald M O'Rourke, Ronald L Wolf, Harish Poptani, S Ali Nabavizadeh
BACKGROUND: Accurate differentiation of brain infections from necrotic glioblastomas (GBMs) may not always be possible on morphologic MRI or on diffusion tensor imaging (DTI) and dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI) if these techniques are used independently. PURPOSE: To investigate the combined analysis of DTI and DSC-PWI in distinguishing brain injections from necrotic GBMs. STUDY TYPE: Retrospective. POPULATION: Fourteen patients with brain infections and 21 patients with necrotic GBMs...
April 20, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29676832/circulating-mirnas-in-acute-new-onset-atrial-fibrillation-and-their-target-mrna-network
#10
Ananília Medeiros Gomes da Silva, Jéssica Nayara Góes de Araújo, Katiene Macêdo de Oliveira, Ana Eloísa Melo Novaes, Mariana Borges Lopes, Júlio César Vieira de Sousa, Antônio Amorim de Araújo Filho, André Ducati Luchessi, Adriana Augusto de Rezende, Mário Hiroyuki Hirata, Vivian Nogueira Silbiger
BACKGROUND: MicroRNAs (miRNAs) are involved in the pathogenesis of atrial fibrillation (AF), acting on development and progression. Our pilot study investigated the expression of six miRNAs and their miRNA-mRNA interactions in patients with acute new-onset AF, well-controlled AF, and normal sinus rhythm (controls). METHODS AND RESULTS: Plasma of acute new-onset AF patients (n = 5) was collected in the emergency room when patients presented with irregular and fast-atrial fibrillation rhythm...
April 20, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29676637/epigenomic-alterations-and-gene-expression-profiles-in-human-respiratory-epithelial-cells-mediated-by-hookah-and-cigarette-smoke
#11
Yin Xiong, Sichuan Xi, Jigui Shan, Elvin Hekimoglu, Shih-Hsin Hsiao, Mary Zhang, Julie A Hong, Chris Tao, Haobin Chen, R Taylor Ripley, Chuong D Hoang, David S Schrump
RATIONALE: The effects of hookah smoke on respiratory epithelia have not been well characterized. OBJECTIVES: To characterize and compare the effects of hookah tobacco smoke and conventional cigarette smoke on the epigenome and transcriptome of human respiratory epithelia. METHODS: Normal human small airway epithelial cells and cyclin-dependent kinase 4/human telomerase reverse transcriptase-immortalized human bronchial epithelial cells were cultured for 5 days in normal media in the presence or absence of water pipe condensates or cigarette smoke condensates under relevant exposure conditions...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676520/chip-based-high-resolution-tandem-mass-spectrometric-determination-of-fibroblast-growth-factor-chondroitin-sulfate-disaccharides-noncovalent-interaction
#12
Adrian C Robu, Laurentiu Popescu, Daniela G Seidler, Alina D Zamfir
Fibroblast growth factor-2 (FGF-2) is involved in wound healing and embryonic development. Glycosaminoglycans (GAGs), the major components of the extracellular matrix (ECM), play fundamental roles at this level. FGF-GAG noncovalent interactions are in the focus of research, due to their influence upon cell proliferation and tissue regeneration. Lately, high resolution mass spectrometry (MS) coupled with chip-nanoelectrospray (nanoESI) contributed a significant progress in glycosaminoglycomics by discoveries related to novel species and their characterization...
April 20, 2018: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29676472/the-first-taxus-rhizosphere-microbiome-revealed-by-shotgun-metagenomic-sequencing
#13
Da-Cheng Hao, Cai-Rong Zhang, Pei-Gen Xiao
In the present study, the shotgun high throughput metagenomic sequencing was implemented to globally capture the features of Taxus rhizosphere microbiome. Total reads could be assigned to 6925 species belonging to 113 bacteria phyla and 301 species of nine fungi phyla. For archaea and virus, 263 and 134 species were for the first time identified, respectively. More than 720,000 Unigenes were identified by clean reads assembly. The top five assigned phyla were Actinobacteria (363,941 Unigenes), Proteobacteria (182,053), Acidobacteria (44,527), Ascomycota (fungi; 18,267), and Chloroflexi (15,539)...
April 20, 2018: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/29676222/clustering-performances-in-the-nba-according-to-players-anthropometric-attributes-and-playing-experience
#14
Shaoliang Zhang, Alberto Lorenzo, Miguel-Angel Gómez, Nuno Mateus, Bruno Gonçalves, Jaime Sampaio
The aim of this study was: (i) to group basketball players into similar clusters based on a combination of anthropometric characteristics and playing experience; and (ii) explore the distribution of players (included starters and non-starters) from different levels of teams within the obtained clusters. The game-related statistics from 699 regular season balanced games were analyzed using a two-step cluster model and a discriminant analysis. The clustering process allowed identifying five different player profiles: Top height and weight (HW) with low experience, TopHW-LowE; Middle HW with middle experience, MiddleHW-MiddleE; Middle HW with top experience, MiddleHW-TopE; Low HW with low experience, LowHW-LowE; Low HW with middle experience, LowHW-MiddleE...
April 20, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29676075/chamber-and-field-studies-demonstrate-differential-amb-a-1-contents-in-common-ragweed-depending-on-co%C3%A2-levels
#15
Young Jin Choi, Hae Rin Oh, Jae Won Oh, Kyu Rang Kim, Mi Jin Kim, Baek Jo Kim, Won Gi Baek
Although atmospheric carbon dioxide (CO₂) has no apparent direct effect on human health, it does have direct effects on plants. The present study evaluated the influence of increased CO₂ levels on the concentration of allergens from common ragweed pollen by setting up a chamber study to model future air conditions and a field study to evaluate current air conditions. For the chamber study, we established 20 ragweed plants in an open-top chamber under different CO₂ levels (380-400, 500-520, 600-620, and 1,000-1,100 parts per million [ppm])...
May 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29676037/dual-layered-film-protected-lithium-metal-anode-to-enable-dendrite-free-lithium-deposition
#16
Chong Yan, Xin-Bing Cheng, Yang Tian, Xiang Chen, Xue-Qiang Zhang, Wen-Jun Li, Jia-Qi Huang, Qiang Zhang
Lithium metal batteries (such as lithium-sulfur, lithium-air, solid state batteries with lithium metal anode) are highly considered as promising candidates for next-generation energy storage systems. However, the unstable interfaces between lithium anode and electrolyte definitely induce the undesired and uncontrollable growth of lithium dendrites, which results in the short-circuit and thermal runaway of the rechargeable batteries. Herein, a dual-layered film is built on a Li metal anode by the immersion of lithium plates into the fluoroethylene carbonate solvent...
April 20, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29675810/neurostimulation-for-memory-enhancement-in-epilepsy
#17
REVIEW
Stephen Meisenhelter, Barbara C Jobst
PURPOSE OF REVIEW: Memory is one of the top concerns of epilepsy patients, but there are no known treatments to directly alleviate the memory deficits associated with epilepsy. Neurostimulation may provide new therapeutic tools to enhance memory in epilepsy patients. Here, we critically review recent investigations of memory enhancement using transcranial electrical stimulation (tES), transcranial magnetic stimulation (TMS), vagus nerve stimulation (VNS), chronic intracranial stimulation, and acute intracranial stimulation...
April 19, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29675781/strategic-supplementation-of-cassava-top-silage-to-enhance-rumen-fermentation-and-milk-production-in-lactating-dairy-cows-in-the-tropics
#18
Metha Wanapat, Kampanat Phesatcha, Bounnaxay Viennasay, Burarat Phesatcha, Thiwakorn Ampapon, Sungchhang Kang
High-quality protein roughage is an important feed for productive ruminants. This study examined the effects of strategic feeding of lactating cows with cassava (Manihot esculenta) top silage (CTS) on rumen fermentation, feed intake, milk yield, and quality. Four early lactating crossbred dairy cows (75% Holstein-Friesian and 25% Thai) with body weight (BW) 410 ± 30 kg and milk yield 12 ± 2 kg/day were randomly allotted in a 4 × 4 Latin square design to four different supplementation levels of CTS namely, 0, 0...
April 19, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29675668/mercury-biomagnification-through-a-coral-reef-ecosystem
#19
Darren G Rumbold, Christopher T Lienhardt, Michael L Parsons
Total mercury (Hg) and stable isotopes of nitrogen and carbon were determined in the muscle tissue of 50 species of fishes and invertebrates collected at two sites along the Florida reef tract from April 2012 to December 2013. The objective was to test the hypothesis that high biodiversity in coral reefs leading to complex food webs with increased lateral links reduces biomagnification. However, Hg levels ranged as high 6.84 mg/kg. Interestingly, it was not highest in great barracuda (Sphyraena barracuda), considered the top predatory fish, but instead in small porkfish (Anisotremus virginicus), possibly due to their role as a cleaner fish...
April 19, 2018: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29675522/modelling-of-adsorption-and-intercalation-of-hydrogen-on-into-tungsten-disulphide-multilayers-and-multiwall-nanotubes
#20
José I Martínez, Alex Laikhtman, Hoi Ri Moon, Alla Zak, Julio A Alonso
Understanding the interaction of hydrogen with layered materials is crucial in the fields of sensors, catalysis, fuel cells and hydrogen storage, among others. Density functional theory, improved by the introduction of van der Waals dispersion forces, provides an efficient and practical workbench to investigate the interaction of molecular and atomic hydrogen with WS2 multilayers and nanotubes. We find that H2 physisorbs on the surface of those materials on top of W atoms, while atomic H chemisorbs on top of S atoms...
April 20, 2018: Physical Chemistry Chemical Physics: PCCP
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