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https://www.readbyqxmd.com/read/27905592/the-conformational-landscape-of-2-4-fluoro-phenyl-ethylamine-consequences-of-fluorine-substitution-at-the-para-position
#1
Afik Shachar, Nitzan Mayorkas, Hanan Sachs, Ilana Bar
Fluorination is considered as a possible means for alteration of conformational landscapes in molecules. The effect of fluorine substitution was studied here by measuring the vibronic and vibrational spectra of gas phase 2-(4-fluoro-phenyl)-ethylamine (4-FPEA) by resonant two-photon ionization (R2PI) and by ionization-loss stimulated Raman spectroscopy (ILSRS). The measurement of survey ILSR spectra of 4-FPEA in the amino group region allowed to associate the bands in the R2PI spectrum to origin and vibronic transitions of the ground (S0) to the excited (S1) electronic states of three different conformers...
December 1, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27904259/profile-and-outcome-of-sudden-cardiac-arrests-in-the-emergency-department-of-a-tertiary-care-hospital-in-south-india
#2
Gautham Raja Pandian, Suma Mary Thampi, Nilanchal Chakraborty, Deepthi Kattula, Paul Prabhakar Abhilash Kundavaram
BACKGROUND: Sudden cardiac arrest (SCA) requiring cardiopulmonary resuscitation (CPR) is one of the common emergencies encountered in the emergency department (ED) of any hospital. Although several studies have reported the predictors of CPR outcome in general, there are limited data from the EDs in India. MATERIALS AND METHODS: This retrospective study included all patients above 18 years with SCA who were resuscitated in the ED of a tertiary care hospital with an annual census of 60,000 patients between August 2014 and July 2015...
October 2016: Journal of Emergencies, Trauma, and Shock
https://www.readbyqxmd.com/read/27898878/effects-of-dietary-fiber-on-the-ideal-standardized-ileal-digestible-threonine-lysine-ratio-for-twenty-five-to-fifty-kilogram-growing-gilts
#3
J K Mathai, J K Htoo, J E Thomson, K J Touchette, H H Stein
Four experiments were conducted to determine effects of fiber on the ideal Thr:Lys ratio for 25- to 50-kg gilts. In Exp. 1, the objective was to determine the requirement for standardized ileal digestible Lys for gilts from 25 to 50 kg BW. Seventy gilts (24.54 ± 3.28 kg BW) were used in a growth assay with 2 pigs per pen, 5 diets, and 7 replicate pens per diet. The 5 diets were based on corn and soybean meal and contained between 0.80 and 1.32% SID Lys. Results indicated that 1.09% SID Lys was needed to optimize ADG and G:F...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898781/evaluation-of-phosphorus-filter-media-for-an-inline-subsurface-drainage-treatment-system
#4
Joseph R Sanford, Rebecca A Larson
Subsurface drainage from agricultural land has been identified as a contributor of both N and P into surface waters, leading to water quality degradation and eutrophication. This study evaluates the ability of P sorption media (PSM; expanded shale, expanded clay, furnace slag, and natural soil) to sorb P in both batch and column tests. Batch sorption tests estimated sorption of 3.4, 1.2, and 0.5 g P kg for expanded shale, expanded clay, and natural soil, respectively. Furnace slag sorption was evaluated for fine (FS), small (FS), and large (FS) particle sizes, with estimated sorption of 6...
November 2016: Journal of Environmental Quality
https://www.readbyqxmd.com/read/27896222/67-kda-laminin-receptor-67lr-in-normal-and-neoplastic-hematopoietic-cells-is-its-targeting-a-feasible-approach
#5
Nunzia Montuori, Ada Pesapane, Valentina Giudice, Bianca Serio, Francesca W Rossi, Amato De Paulis, Carmine Selleri
The 67 kDa laminin receptor (67LR) is a non-integrin cell surface receptor for laminin (LM) that derives from a 37 kDa precursor (37LRP). 67LR expression is increased in neoplastic cells and correlates with an enhanced invasive and metastatic potentialin many human solid tumors, recommending this receptor as a new promising target for cancer therapy. This is supported by in vivo studies showing that 67LR downregulation reduces tumour cell proliferation and tumour formation by inducing apoptosis. 67LR association with the anti-apoptotic protein PED/PEA-15 activates a signal transduction pathway, leading to cell proliferation and resistance to apoptosis...
November 2016: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/27895889/amino-acid-transporters-implicated-in-endocytosis-of-buchnera-during-symbiont-transmission-in-the-pea-aphid
#6
Hsiao-Ling Lu, Chun-Che Chang, Alex C C Wilson
BACKGROUND: Many insects host their obligate, maternally transmitted symbiotic bacteria in specialized cells called bacteriocytes. One of the best-studied insect nutritional endosymbioses is that of the aphid and its endosymbiont, Buchnera aphidicola. Aphids and Buchnera are metabolically and developmentally integrated, but the molecular mechanisms underlying Buchnera transmission and coordination with aphid development remain largely unknown. Previous work using electron microscopy to study aphid asexual embryogenesis has revealed that Buchnera transmission involves exocytosis from a maternal bacteriocyte followed by endocytotic uptake by a blastula...
2016: EvoDevo
https://www.readbyqxmd.com/read/27893854/dissemination-and-mechanism-for-the-mcr-1-colistin-resistance
#7
Rongsui Gao, Yongfei Hu, Zhencui Li, Jian Sun, Qingjing Wang, Jingxia Lin, Huiyan Ye, Fei Liu, Swaminath Srinivas, Defeng Li, Baoli Zhu, Ya-Hong Liu, Guo-Bao Tian, Youjun Feng
Polymyxins are the last line of defense against lethal infections caused by multidrug resistant Gram-negative pathogens. Very recently, the use of polymyxins has been greatly challenged by the emergence of the plasmid-borne mobile colistin resistance gene (mcr-1). However, the mechanistic aspects of the MCR-1 colistin resistance are still poorly understood. Here we report the comparative genomics of two new mcr-1-harbouring plasmids isolated from the human gut microbiota, highlighting the diversity in plasmid transfer of the mcr-1 gene...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27891761/agro-ecological-management-of-a-soil-dwelling-orthopteran-pest-in-vineyards
#8
Jerry Asalma Nboyine, Stephane Boyer, David J Saville, Stephen David Wratten
The efficacy of different combinations of under-vine and inter-row treatments for managing a soil-dwelling orthopteran pest, weta (Hemiandrus sp.), in vineyards was investigated over two seasons. This insect damages vine buds, thus reducing subsequent grape yield. The under-vine treatments comprised pea straw mulch, mussel shells, tick beans (Vicia faba Linn. var minor (Fab)), plastic sleeves on vine trunks (treated control) and control (no intervention), while inter-rows contained either the existing vegetation or tick beans...
November 28, 2016: Insect Science
https://www.readbyqxmd.com/read/27889013/methicillin-resistant-staphylococcus-aureus-infections-a-review-of-the-currently-available-treatment-options
#9
REVIEW
S M Purrello, J Garau, E Giamarellos, T Mazzei, F Pea, A Soriano, S Stefani
This review is the result of discussions that took place at the 5th MRSA Working Group Consensus Meeting and explores the possible treatment options available for different types of infections due to methicillin-resistant Staphylococcus aureus (MRSA), focusing on those antibiotics that could represent a valid alternative to vancomycin. In fact, whilst vancomycin remains a viable option, its therapy is moving towards individualised dosing. Other drugs, such as the new lipoglycopeptides (oritavancin, dalbavancin and telavancin) and fifth-generation cephalosporins (ceftaroline and ceftobiprole), are showing good in vitro potency and in vivo efficacy, especially for patients infected with micro-organisms with higher vancomycin minimum inhibitory concentrations (MICs)...
December 2016: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27888672/incidence-of-coronary-intervention-in-cardiac-arrest-survivors-with-non-shockable-initial-rhythms-and-no-evidence-of-st-elevation-mi-stemi
#10
Matthew Wilson, Anne V Grossestreuer, David F Gaieski, Benjamin S Abella, William Frohna, Munish Goyal
OBJECTIVE: With the demonstrated benefit of an early-invasive strategy for STEMI and VF/VT arrest patients, there is interest in assessing the potential benefit of early angiography for non-shockable (PEA/Asystole) arrest patients. We hypothesized that in cardiac arrest patients who obtain return of spontaneous circulation (ROSC) after a non-shockable initial rhythm and do not have STEMI the incidence of coronary intervention would be clinically insignificant (<5%). METHODS: Retrospective multicenter US clinical registry study of post-cardiac arrest patients at 18 hospitals between 1/00 and 5/14...
November 23, 2016: Resuscitation
https://www.readbyqxmd.com/read/27881806/how-do-gloves-affect-cutaneous-sensibility-in-medical-practice-two-new-applied-tests
#11
Peter Mylon, Matt J Carré, Nicolas Martin, Roger Lewis
In order to quantify the effect of medical gloves on tactile performance, two new Simulated Medical Examination Tactile Tests (SMETT) have been developed to replicate the tactile and haptic ability required in medical examinations: the 'Bumps' test and the 'Princess and the Pea' (P&P) test. A pilot study was carried out using 30-40 subjects for each test in order to investigate the suitability of the tests for medical glove evaluation. Tests were performed with latex and nitrile examination gloves and without gloves...
November 23, 2016: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/27881619/accumulation-and-determination-of-phenylethanolamine-a-residue-in-hair-of-swine-and-sheep
#12
Suo Decheng, Wang Ruiguo, Wang Peilong, Zhao Genlong, Fan Yufei, Fan Xia, Li Yang, Su Xiaoou
The present study proposed the use of liquid chromatography-tandem mass spectrometry to detect the novel β-agonist phenylethanolamine A (PEA) in incurred hair samples of swine and sheep and to assess its accumulation for residue monitoring. The method showed good percent recoveries ranging from 93.2% to 102% and good coefficient of variation at <15%. The experiment was conducted in swine (24 treated and 4 controls) and sheep (3 treated and 1 control). PEA concentration was determined in hair during the treatment...
November 22, 2016: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/27875577/heat-stress-affects-facultative-symbiont-mediated-protection-from-a-parasitoid-wasp
#13
Eleanor R Heyworth, Julia Ferrari
Many insects carry facultative bacterial symbionts, which provide benefits including resistance to natural enemies and abiotic stresses. Little is known about how these beneficial phenotypes are affected when biotic or abiotic threats occur simultaneously. The pea aphid (Acyrthosiphon pisum) can host several well-characterized symbiont species. The symbiont known as X-type can protect against both parasitoid wasps and heat stress. Here, we used three pea aphid genotypes that were naturally infected with X-type and the symbiont Spiroplasma sp...
2016: PloS One
https://www.readbyqxmd.com/read/27873056/individual-pheromone-signature-in-males-prerequisite-for-pheromone-mediated-mate-assessment-in-the-central-american-locust-schistocerca-piceifrons
#14
Christiane Stahr, Karsten Seidelmann
Living in high-density groups of animals has advantages and disadvantages for mating. The advantage of facilitated mate finding is compromised by difficulties in protecting a suitable partner from competitors. Thus, males regularly are faced with increased competition for sperm, and females with harassment by males at high population densities. To cope with these problems, mating tactics and mate choice mechanisms have to be adjusted. An adaptation to gregarious condition observed in locusts includes the use of male-emitted pheromones...
November 21, 2016: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/27871881/targeting-brain-and-peripheral-plasticity-of-the-lipidome-in-acute-kainic-acid-induced-epileptic-seizures-in-mice-via-quantitative-mass-spectrometry
#15
Raissa Lerner, Julia Post, Sebastian Loch, Beat Lutz, Laura Bindila
Epilepsy is a highly common chronic neurological disorder, manifested in many different types, affecting ~1% of the worldwide human population. The molecular mechanisms of epileptogenesis has not yet been clarified, and pharmacoresistance exhibited by 30-40% of epilepsy patients remains a major obstacle in medical care. Growing evidence indicates a role of lipid signalling pathways in epileptogenesis, thus lipid signals emerge as potential biomarkers for the onset and evolving course of the epileptic disorder, as well as potential therapeutic agents and targets...
November 15, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27869713/role-of-pea-enation-mosaic-virus-coat-protein-in-the-host-plant-and-aphid-vector
#16
Juliette Doumayrou, Melissa Sheber, Bryony C Bonning, W Allen Miller
Understanding the molecular mechanisms involved in plant virus-vector interactions is essential for the development of effective control measures for aphid-vectored epidemic plant diseases. The coat proteins (CP) are the main component of the viral capsids, and they are implicated in practically every stage of the viral infection cycle. Pea enation mosaic virus 1 (PEMV1, Enamovirus, Luteoviridae) and Pea enation mosaic virus 2 (PEMV2, Umbravirus, Tombusviridae) are two RNA viruses in an obligate symbiosis causing the pea enation mosaic disease...
November 18, 2016: Viruses
https://www.readbyqxmd.com/read/27867393/melatonin-application-to-pisum-sativum-l-seeds-positively-influences-the-function-of-the-photosynthetic-apparatus-in-growing-seedlings-during-paraquat-induced-oxidative-stress
#17
Katarzyna Szafrańska, Russel J Reiter, Małgorzata M Posmyk
Melatonin, due to its pleiotropic effects plays an important role improving tolerance to stresses. Plants increase endogenous melatonin synthesis when faced with harsh environments as well as exogenously applied melatonin limits stress injuries. Presented work demonstrated that single melatonin application into the seeds during pre-sowing priming improved oxidative stress tolerance of growing seedlings exposed to paraquat (PQ). PQ is a powerful herbicide which blocks the process of photosynthesis under light conditions due to free radicals excess production, when O2 is rapidly converted to [Formula: see text] and subsequently to other reactive oxygen species...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27864224/infection-by-rhodococcus-fascians-maintains-cotyledons-as-a-sink-tissue-for-the-pathogen
#18
Pragatheswari Dhandapani, Jiancheng Song, Ondrej Novak, Paula E Jameson
BACKGROUND AND AIMS: Pisum sativum L. (pea) seed is a source of carbohydrate and protein for the developing plant. By studying pea seeds inoculated by the cytokinin-producing bacterium, Rhodococcus fascians, we sought to determine the impact of both an epiphytic (avirulent) strain and a pathogenic strain on source-sink activity within the cotyledons during and following germination. METHODS: Bacterial spread was monitored microscopically, and real-time reverse transcription-quantitative PCR was used to determine the expression of cytokinin biosynthesis, degradation and response regulator gene family members, along with expression of family members of SWEET, SUT, CWINV and AAP genes - gene families identified initially in pea by transcriptomic analysis...
November 17, 2016: Annals of Botany
https://www.readbyqxmd.com/read/27862368/effects-of-heat-treatment-on-protein-feeds-evaluated-in%C3%A2-vitro-by-the-method-of-estimating-utilisable-crude-protein-at-the-duodenum
#19
M Vaga, M Hetta, P Huhtanen
The effect of heat treatment on the protein value of field beans, lupins and peas was studied using an in vitro method. Protein feeds were subjected to heat treatment for 30, 60 and 90 min in forced air oven at 120, 140 and 160 °C and in autoclave at 105, 120 and 135 °C. The heat-treated protein feeds were incubated in buffered rumen fluid together with grass silage and barley in complete isonitrogenous diets. The gas production (GP) was recorded continuously, and ammonia-N (NH3 -N) concentrations were determined during the in vitro incubation at 8, 24 and 48 h and used to determine the utilisable crude protein (uCP) at the duodenum at 16 h of incubation (uCP16 )...
November 11, 2016: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/27852126/traditional-chinese-medicine-food-therapy-and-hypertension-control-a-narrative-review-of-chinese-literature
#20
Ping Zou
Despite the lack of English literature about Traditional Chinese Medicine (TCM) food therapy, there is abundant Chinese literature about the application of food therapy for hypertension control. This paper summarizes basic concepts of TCM, the principles of food therapy and its application for hypertension control according to Chinese literature. In TCM, food is conceptualized according to both nutritional and functional aspects, and can be used to treat illnesses. Four principles of TCM food therapy including light eating, balancing the "hot" and "cold" nature of food, the harmony of the five flavors of food, and consistency between dietary intake and different health conditions, can be used to facilitate hypertension control...
November 16, 2016: American Journal of Chinese Medicine
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