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https://www.readbyqxmd.com/read/28238808/hypophosphatasia-an-overview-for-2017
#1
Michael P Whyte
Hypophosphatasia (HPP) is the inborn-error-of-metabolism that features low serum alkaline phosphatase (ALP) activity (hypophosphatasemia) caused by loss-of-function mutation(s) of the gene that encodes the tissue-nonspecific isoenzyme of ALP (TNSALP). Autosomal recessive or autosomal dominant inheritance from among >300 TNSALP (ALPL) mutations largely explains HPP's remarkably broad-ranging severity. TNSALP is a cell-surface homodimeric phosphohydrolase richly expressed in the skeleton, liver, kidney, and developing teeth...
February 24, 2017: Bone
https://www.readbyqxmd.com/read/28238159/analyses-of-pea-necrotic-yellow-dwarf-virus-encoded-proteins
#2
Björn Krenz, Ingrid Schießl, Eva Greiner, Susanna Krapp
Pea necrotic yellow dwarf virus (PNYDV) is a multipartite, circular, single-stranded DNA plant virus. PNYDV encodes eight proteins and the function of three of which remains unknown-U1, U2, and U4. PNYDV proteins cellular localization was analyzed by GFP tagging and bimolecular fluorescence complementation (BiFC) studies. The interactions of all eight PNYDV proteins were tested pairwise in planta (36 combinations in total). Seven interactions were identified and two (M-Rep with CP and MP with U4) were characterized further...
February 25, 2017: Virus Genes
https://www.readbyqxmd.com/read/28237711/pharmacological-inhibition-of-faah-modulates-tlr-induced-neuroinflammation-but-not-sickness-behaviour-an-effect-partially-mediated-by-central-trpv1
#3
Rebecca J Henry, Daniel M Kerr, Lisa E Flannery, Marykate Killilea, Edel M Hughes, Louise Corcoran, David P Finn, Michelle Roche
Aberrant activation of toll-like receptors (TLRs), key components of the innate immune system, has been proposed to underlie and exacerbate a range of central nervous system disorders. Increasing evidence supports a role for the endocannabinoid system in modulating inflammatory responses including those mediated by TLRs, and thus this system may provide an important treatment target for neuroinflammatory disorders. However, the effect of modulating endocannabinoid tone on TLR-induced neuroinflammation in vivo and associated behavioural changes is largely unknown...
February 22, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28235563/characterisation-analysis-of-expression-and-localisation-of-circadian-clock-genes-from-the-perspective-of-photoperiodism-in-the-aphid-acyrthosiphon-pisum
#4
Miquel Barberà, Jorge Mariano Collantes-Alegre, David Martínez-Torres
Aphids are typical photoperiodic insects that switch from viviparous parthenogenetic reproduction typical of long day seasons to oviparous sexual reproduction triggered by the shortening of photoperiod in autumn yielding an overwintering egg in which an embryonic diapause takes place. While the involvement of the circadian clock genes in photoperiodism in mammals is well established, there is still some controversy on their participation in insects. The availability of the genome of the pea aphid Acyrthosiphon pisum places this species as an excellent model to investigate the involvement of the circadian system in the aphid seasonal response...
February 21, 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28231174/optimization-of-ultrasound-assisted-extraction-preliminary-characterization-and-in-vitro-antioxidant-activity-of-polysaccharides-from-green-pea-pods
#5
Maryam Jalili Safaryan, Ali Ganjloo, Mandana Bimakr, Soheila Zarringhalami
In this study, ultrasound-assisted extraction of green pea pod polysaccharide (GPPP) was investigated and optimized using a central composite response surface design coupled with a numerical optimization technique. The effects of ultrasonic power (50-150 W), sonication time (20-80 min), ratio of water to raw material (20:1-40:1 mL/g) and extraction temperature (40-80 °C) on polysaccharide extraction yield were studied. The maximum extraction yield was obtained with a sonication power of 135.34 W, extraction time of 48...
November 28, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28231135/changes-in-food-intake-in-australia-comparing-the-1995-and-2011-national-nutrition-survey-results-disaggregated-into-basic-foods
#6
Bradley Ridoutt, Danielle Baird, Kathryn Bastiaans, Gilly Hendrie, Malcolm Riley, Peerasak Sanguansri, Julie Syrette, Manny Noakes
As nations seek to address obesity and diet-related chronic disease, understanding shifts in food intake over time is an imperative. However, quantifying intake of basic foods is not straightforward because of the diversity of raw and cooked wholefoods, processed foods and mixed dishes actually consumed. In this study, data from the Australian national nutrition surveys of 1995 and 2011, each involving more than 12,000 individuals and covering more than 4500 separate foods, were coherently disaggregated into basic foods, with cooking and processing factors applied where necessary...
May 25, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28231121/the-effects-of-fortification-of-legumes-and-extrusion-on-the-protein-digestibility-of-wheat-based-snack
#7
Swapnil S Patil, Margaret A Brennan, Susan L Mason, Charles S Brennan
Cereal food products are an important part of the human diet with wheat being the most commonly consumed cereal in many parts of the world. Extruded snack products are increasing in consumer interest due to their texture and ease of use. However, wheat based foods are rich in starch and are associated with high glycaemic impact products. Although legume materials are generally rich in fibre and protein and may be of high nutritive value, there is a paucity of research regarding their use in extruded snack food products...
April 6, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28231112/a-comparison-of-carbon-footprint-and-production-cost-of-different-pasta-products-based-on-whole-egg-and-pea-flour
#8
Antonia Nette, Patricia Wolf, Oliver Schlüter, Andreas Meyer-Aurich
Feed and food production are inter alia reasons for high greenhouse gas emissions. Greenhouse gas emissions could be reduced by the replacement of animal components with plant components in processed food products, such as pasta. The main components currently used for pasta are semolina, and water, as well as additional egg. The hypothesis of this paper is that the substitution of whole egg with plant-based ingredients, for example from peas, in such a product might lead to reduced greenhouse gas emissions (GHG) and thus a reduced carbon footprint at economically reasonable costs...
March 4, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28230263/recent-advances-in-%C3%AE-aminobutyric-acid-gaba-properties-in-pulses-an-overview
#9
REVIEW
Nooshin Nikmaram, B N Dar, Shahin Roohinejad, Mohamed Koubaa, Francisco J Barba, Greiner Ralf, Stuart K Johnson
Beans, peas, and lentils are all types of pulses that are extensively used as foods around the world due to their beneficial effects on human health including their low glycemic index, cholesterol lowering effects, ability to decrease the risk of heart diseases and their protective effects against some cancers. These health benefits are a result of their components such as bioactive proteins, dietary fibers, slowly digested starches, minerals and vitamins, and bioactive compounds. Among these bioactive compounds, γ-aminobutyric acid (GABA), a non-proteinogenic amino acid with numerous reported health benefits (e...
February 23, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28229130/traits-affecting-early-season-nitrogen-uptake-in-nine-legume-species
#10
Elana Dayoub, Christophe Naudin, Guillaume Piva, Steven J Shirtliffe, Joëlle Fustec, Guénaëlle Corre-Hellou
Legume crops are known to have low soil N uptake early in their life cycle, which can weaken their ability to compete with other species, such as weeds or other crops in intercropping systems. However, there is limited knowledge on the main traits involved in soil N uptake during early growth and for a range of species. The objective of this research was to identify the main traits explaining the variability among legume species in soil N uptake and to study the effect of the soil mineral N supply on the legume strategy for the use of available N sources during early growth...
February 2017: Heliyon
https://www.readbyqxmd.com/read/28218209/clinical-study-of-acute-vasoreactivity-testing-in-patients-with-chronic-thromboembolic-pulmonary-hypertension
#11
Qi-Xia Xu, Yuan-Hua Yang, Jie Geng, Zhen-Guo Zhai, Juan-Ni Gong, Ji-Feng Li, Xiao Tang, Chen Wang
BACKGROUND: The clinical significance of acute vasoreactivity testing (AVT) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) remains unclear. We analyzed changes in hemodynamics and oxygenation dynamics indices after AVT in patients with CTEPH using patients with pulmonary arterial hypertension (PAH) as controls. METHODS: We analyzed retrospectively the results of AVT in 80 patients with PAH and 175 patients with CTEPH registered in the research database of Beijing Chao-Yang Hospital between October 2005 and August 2014...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28216548/hyperglycemia-aggravates-decreases-of-pea-15-and-its-two-phosphorylated-forms-in-cerebral-ischemia
#12
Jin-Hee Sung, Phil-Ok Koh
Diabetes is a metabolic health disorder and an important risk factor for stroke. Phosphoprotein enriched in astrocytes 15 (PEA-15) is a multifunctional protein modulating cell proliferation, survival, apoptosis and glucose metabolism. This study investigated whether diabetes modulates the expression of PEA-15 and two phosphorylated forms (Ser 104 and Ser 116) in middle cerebral artery occlusion (MCAO)-induced brain injury. Male Sprague-Dawley rats were administrated with streptozotocin (40 mg/kg) and were underwent right middle cerebral artery occlusion (MCAO) 4 weeks after streptozotocin injection...
February 17, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28215162/gut-brain-axis-role-of-lipids-in-the-regulation-of-inflammation-pain-and-cns-diseases
#13
Roberto Russo, Claudia Cristiano, Carmen Avagliano, Carmen De Caro, Giovanna La Rana, Giuseppina Mattace Raso, Roberto Berni Canani, Rosaria Meli, Antonio Calignano
The human gut is a composite anaerobic environment with a large, diverse and dynamic enteric microbiota, represented by more than 100 trillion microorganisms, including at least 1000 distinct species. The discovery that a different microbial composition can influence behavior and cognition, and in turn the nervous system can indirectly influence enteric microbiota composition, has significantly contributed to establish the well-accepted concept of gut-brain axis. This hypothesis is supported by several evidence showing mutual mechanisms, which involve the vague nerve, the immune system, the hypothalamic-pituitary-adrenal (HPA) axis modulation and the bacteria-derived metabolites...
February 16, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28213038/hydrolysate-from-a-mixture-of-legume-flours-with-antifungal-activity-as-an-ingredient-for-prolonging-the-shelf-life-of-wheat-bread
#14
Carlo Giuseppe Rizzello, Michela Verni, Stefano Bordignon, Valerio Gramaglia, Marco Gobbetti
Aiming at identifying antifungal compounds from plant matrices to be used as ingredients in the bakery industry, a water/salt-soluble extract (WSE) was produced from a legume enzyme hydrolysate, consisting of a mixture of pea, lentil, and faba bean flours, and assayed towards Penicillium roqueforti DPPMAF1. Agar diffusion assays allowed the selection of the optimal processing conditions for hydrolysis. As shown by hyphal radial growth rate, the inhibition was observed towards several fungi, including Aspergillus parasiticus CBS971...
June 2017: Food Microbiology
https://www.readbyqxmd.com/read/28213013/time-course-of-germination-initiation-of-mycelium-proliferation-and-probability-of-visible-growth-and-detectable-afb1-production-of-an-isolate-of-aspergillus-flavus-on-pistachio-extract-agar
#15
Laila Aldars-García, Vicente Sanchis, Antonio J Ramos, Sonia Marín
The aim of this work was to assess the temporal relationship among quantified germination, mycelial growth and aflatoxin B1 (AFB1) production from colonies coming from single spores, in order to find the best way to predict as accurately as possible the presence of AFB1 at the early stages of contamination. Germination, mycelial growth, probability of growth and probability of AFB1 production of an isolate of Aspergillus flavus were determined at 25 °C and two water activities (0.85 and 0.87) on 3% Pistachio Extract Agar (PEA)...
June 2017: Food Microbiology
https://www.readbyqxmd.com/read/28212324/differential-gene-expression-in-the-meristem-and-during-early-fruit-growth-of-pisum-sativum-l-identifies-potential-targets-for-breeding
#16
Annu Smitha Ninan, Anish Shah, Jiancheng Song, Paula E Jameson
For successful molecular breeding it is important to identify targets to the gene family level, and in the specific species of interest, in this case Pisum sativum L. The cytokinins have been identified as a key breeding target due to their influence on plant architecture, and on seed size and sink activity. We focused on the cytokinin biosynthetic gene family (the IPTs) and the gene family key to the destruction of cytokinins (the CKXs), as well as other gene families potentially affected by changing cytokinin levels...
February 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28211052/life-history-strategy-determines-constraints-on-immune-function
#17
Benjamin J Parker, Seth M Barribeau, Alice M Laughton, Lynn H Griffin, Nicole M Gerardo
1)Determining the factors governing investment in immunity is critical for understanding host-pathogen ecological and evolutionary dynamics. Studies often consider disease resistance in the context of life-history theory, with the expectation that investment in immunity will be optimized in anticipation of disease risk. Immunity, however, is constrained by context-dependent fitness costs. How the costs of immunity vary across life-history strategies has yet to be considered. 2)Pea aphids are typically unwinged but produce winged offspring in response to high population densities and deteriorating conditions...
February 17, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28207303/growth-of-listeria-monocytogenes-in-thawed-frozen-foods
#18
Ai Kataoka, Hua Wang, Philip H Elliott, Richard C Whiting, Melinda M Hayman
The growth characteristics of Listeria monocytogenes inoculated onto frozen foods (corn, green peas, crabmeat, and shrimp) and thawed by being stored at 4, 8, 12, and 20°C were investigated. The growth parameters, lag-phase duration (LPD) and exponential growth rate (EGR), were determined by using a two-phase linear growth model as a primary model and a square root model for EGR and a quadratic model for LPD as secondary models, based on the growth data. The EGR model predictions were compared with growth rates obtained from the USDA Pathogen Modeling Program, calculated with similar pH, salt percentage, and NaNO2 parameters, at all storage temperatures...
February 16, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28206892/influence-of-the-amount-of-dentifrice-and-fluoride-concentrations-on-salivary-fluoride-levels-in-children
#19
Kevin Bruce Hall, Alberto Carlos Botazzo Delbem, Mariana Emi Nagata, Thayse Yumi Hosida, Felipe Ricardo Nunes de Moraes, Marcelle Danelon, Robson Frederico Cunha, Juliano Pelim Pessan
PURPOSE: This study evaluated fluoride (F) concentrations in saliva of children after brushing with dentifrices containing different F concentrations (zero, 550, and 1,100 ppm F) in different quantities (full bristles, transversal technique, and pea-sized). METHODS: Eight- to 10-year-old volunteers (<small>N</small>=24) were randomly assigned into nine experimental groups (dentifrice type versus amounts) following a double-blind, crossover protocol. After a one-week washout period (use of placebo toothpaste), stimulated saliva was collected prior to toothbrushing (baseline) and at five, 15, 30, 60, and 120 minutes after toothbrushing with one of the possible combinations...
October 15, 2016: Pediatric Dentistry
https://www.readbyqxmd.com/read/28202598/early-flowering-3-redundancy-fine-tunes-photoperiod-sensitivity
#20
Andrew J S Rubenach, Valerie Fg Hecht, Jacqueline K Vander Schoor, Lim Chee Liew, Gregoire Aubert, Judith Burstin, James L Weller
Three pea loci controlling photoperiod sensitivity, HIGH RESPONSE (HR), DIE NEUTRALIS (DNE) and STERILE NODES (SN) have recently been shown to correspond to orthologs of Arabidopsis circadian clock genes EARLY FLOWERING3 (ELF3), ELF4, and LUX ARRHYTHMO, respectively. A fourth pea locus, PHOTOPERIOD (PPD), also contributes to the photoperiod response in a similar manner to SN and DNE, and recessive ppd mutants on a spring-flowering hr mutant background show early, photoperiod-insensitive flowering. However, the molecular identity of PPD has so far remained elusive...
February 15, 2017: Plant Physiology
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