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https://www.readbyqxmd.com/read/28806777/a-synthetic-sickness-screen-for-senescence-re-engagement-targets-in-mutant-cancer-backgrounds
#1
Claire J Cairney, Lauren S Godwin, Alan E Bilsland, Sharon Burns, Katrina H Stevenson, Lynn McGarry, John Revie, Jon D Moore, Ceri M Wiggins, Rebecca S Collinson, Clare Mudd, Elpida Tsonou, Mahito Sadaie, Dorothy C Bennett, Masashi Narita, Christopher J Torrance, W Nicol Keith
Senescence is a universal barrier to immortalisation and tumorigenesis. As such, interest in the use of senescence-induction in a therapeutic context has been gaining momentum in the past few years; however, senescence and immortalisation remain underserved areas for drug discovery owing to a lack of robust senescence inducing agents and an incomplete understanding of the signalling events underlying this complex process. In order to address this issue we undertook a large-scale morphological siRNA screen for inducers of senescence phenotypes in the human melanoma cell line A375P...
August 14, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28806693/persistence-of-urban-organic-aerosols-composition-decoding-their-structural-complexity-and-seasonal-variability
#2
João T V Matos, Regina M B O Duarte, Sónia P Lopes, Artur M S Silva, Armando C Duarte
Organic Aerosols (OAs) are typically defined as highly complex matrices whose composition changes in time and space. Focusing on time vector, this work uses two-dimensional nuclear magnetic resonance (2D NMR) techniques to examine the structural features of water-soluble (WSOM) and alkaline-soluble organic matter (ASOM) sequentially extracted from fine atmospheric aerosols collected in an urban setting during cold and warm seasons. This study reveals molecular signatures not previously decoded in NMR-related studies of OAs as meaningful source markers...
August 11, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28805934/fragility-of-epidermis-acne-and-post-procedure-lesional-skin
#3
G Fabbrocini, A B Rossi, M-D Thouvenin, C Peraud, V Mengeaud, A Bacquey, M Saint Aroman
'Fragile skin', or skin with lower resistance to aggressors, can be broadly classified into four causal categories: constitutional (age-dependent or associated with specific vulnerable locations on the body, e.g. eyelids), pathological (related to disease), circumstantial (related to environmental or internal factors, e.g. stress) and iatrogenic (caused by medical interventions or treatments). In this supplement, we focus on the fourth category, the iatrogenic origin of fragile skin and the role that dermo-cosmetics can have in restoring the natural protective function of the skin following treatments for skin diseases and medical interventions...
September 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28805877/a-dna-bipedal-nanowalker-with-a-piston-like-expulsion-stroke
#4
Q Y Yeo, I Y Loh, S R Tee, Y H Chiang, J Cheng, M H Liu, Z S Wang
Artificial molecular walkers beyond burn-bridge designs are important for nanotechnology, but their systematic development remains difficult. Herein, we have reported a new rationally designed DNA walker-track system and experimentally verified a previously proposed general expulsion regime for implementing non-burn-bridge nanowalkers. The DNA walker has an optically powered engine motif that reversibly extends and contracts the walker via a quadruplex-duplex conformational change. The walker's extension is an energy-absorbing and force-generating process, which drives the walker's leg dissociation off-track in a piston-like expulsion stroke...
August 14, 2017: Nanoscale
https://www.readbyqxmd.com/read/28805754/-a-phenomenological-analysis-of-non-suicidal-self-injuries-in-adolescents
#5
O B Levkovskaja, Ju S Shevchenko, L Ju Danilova, V V Grachev
AIM: To perform a phenomenological/clinical/psychopathological analysis of non-suicidal self-injury behavior (NSSI) in adolescents. MATERIAL AND METHODS: The authors studied 155 adolescents, 140 girls and 15 boys, aged 12-17 years, including 111 with self-cutting, 5 with self-burning, 4 with self-beating. Other cases included combined, multiple and other variants of NSSI. RESULTS AND CONCLUSION: NSSI develop more often in female teenagers...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28804804/life-cycle-environmental-impacts-of-bioethanol-production-from-sugarcane-molasses-in-iran
#6
Saeid Shahvarooghi Farahani, Mohammad Amin Asoodar
In recent years, bioethanol from sugarcane molasses has been produced on an industrial scale in Iran. The aim of this study was to evaluate molasses-based bioethanol production from an environmental point of view. Data were collected from Debel Khazai agro-industry situated in southern region of Iran by using face-to-face interviews and annual statistics of 2010 to 2016 (6-year life cycle of sugarcane cultivation). Ten impact categories including abiotic depletion (AD), acidification (AC), eutrophication (EP), global warming potential (GWP), ozone layer depletion (OLD), human toxicity (HT), freshwater aquatic ecotoxicity (FE), marine aquatic ecotoxicity (ME), terrestrial ecotoxicity (TE), and photochemical oxidation (PO) were selected based on CML methodology...
August 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28804686/a-comparative-study-of-tissue-expansion-and-free-parascapular-flaps-in-extensive-facial-burn-scar-reconstruction
#7
G S Kalra, Mitesh Bedi, Vipin Kumar Barala
BACKGROUND: Large post burn scars are a very difficult problem to treat. Available methods include skin grafts and tissue expansion. The reconstructive method used should be tailored according to individual patient rather than following a textbook approach in each. PATIENTS AND METHODS: A retrospective analysis was done of cases with extensive facial burn scars in whom secondary reconstruction was done with either free parascapular flap cover or tissue expansion and flap advancement following facial burn scar excision by a single surgeon (GSK) in Department of Burns, Plastic and reconstructive surgery...
2017: International Journal of Burns and Trauma
https://www.readbyqxmd.com/read/28803936/slurp1-promotes-corneal-angiogenic-privilege-by-suppressing-nuclear-translocation-of-nf%C3%AE%C2%BAb
#8
Sudha Swamynathan, Chelsea L Loughner, Shivalingappa K Swamynathan
Previously, we have reported that the Secreted Ly6/uPAR related protein-1 (SLURP1) serves an important immunomodulatory function in the ocular surface. Here, we examine the involvement of SLURP1 in regulating corneal angiogenic privilege. Slurp1 expression detected by QPCR, immunoblots and immunofluorescent stain, was significantly decreased in mouse corneas subjected to alkali burn-induced corneal neovascularization (CNV). Addition of exogenous SLURP1 (6XHis-tagged, E. coli expressed and partially purified using Ni-ion columns) significantly suppressed the tumor necrosis factor-α (TNF-α)-stimulated human umbilical cord vascular endothelial cell (HUVEC) tube formation...
August 10, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28803752/optimal-dose-timing-and-ratio-of-blood-products-in-massive-transfusion-results-from-a-systematic-review
#9
REVIEW
Zoe K McQuilten, Gemma Crighton, Susan Brunskill, Jessica K Morison, Tania H Richter, Neil Waters, Michael F Murphy, Erica M Wood
Optimal dose, timing and ratio to red blood cells (RBC) of blood component therapy (fresh frozen plasma [FFP], platelets, cryoprecipitate or fibrinogen concentrate) to reduce morbidity and mortality in critically bleeding patients requiring massive transfusion is unknown. We performed a systematic review for randomized controlled trials (RCT) in MEDLINE, The Cochrane Library, Embase, CINAHL, PubMed the Transfusion Evidence Library and using multiple clinical trials registries to 21 February 2017. Sixteen RCTs were identified: six completed (five in adult trauma patients, one pediatric burn patients) and ten ongoing trials...
July 6, 2017: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/28803724/implementation-and-outcomes-of-an-evidence-based-precepting-program-for-burn-nurses
#10
Johnnie R Robbins, Krystal K Valdez-Delgado, Nicole W Caldwell, Linda H Yoder, Elizabeth J Hayes, Michaèl G Barba, Hope L Greeley, Colleen Mitchell, Elizabeth A Mann-Salinas
INTRODUCTION: There is significant nationwide interest in transitioning new and new-to-specialty nurses into practice, especially in burn care. Lack of a structured transition program in our Burn Center was recognized as a contributing factor for nursing dissatisfaction and increased turnover compared to other hospital units. Employee evaluations exposed a need for more didactic instruction, hands-on learning, and preceptor support. The goal of this project was to implement an evidence-based transition to practice program specific to the burn specialty...
August 10, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28803723/perceived-social-support-among-patients-with-burn-injuries-a-perspective-from-the-developing-world
#11
Ahmed Waqas, Marvee Turk, Sadiq Naveed, Atif Amin, Harriet Kiwanuka, Neha Shafique, Muhammad Ashraf Chaudhry
BACKGROUND: Social support is among the most well-established predictors of post-burn psychopathology after burn. Despite a disproportionately large burden of burns in the developing world, the nature of social support among burn patients in this context remains elusive. We, therefore, seek to investigate social support and its biopsychosocial determinants among patients with burn injuries in Pakistan. METHODS: A cross-sectional study of 343 patients presenting with burn injuries at four teaching hospitals in the Punjab province of Pakistan was conducted...
August 10, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28803606/effect-of-dermabrasion-and-recell-%C3%A2-on-large-superficial-facial-scars-caused-by-burn-trauma-and-acnes
#12
Pan-Xi Yu, Wen-Qi Diao, Zuo-Liang Qi, Jing-Long Cai
Objective To explore the effects of dermabrasion combined with ReCell(®) on large superficial facial scars caused by burn, trauma and acnes.Methods Nineteen patients with large superficial facial scars were treated by the same surgeon with dermabrasion combined with ReCell(®). According to the etiology, patients were classified into post-burning group (n=5), post-traumatic group (n=7) and post-acne group (n=7). Fifteen patients completed the follow-ups, 5 patients in each group. Healing time, complication rate, the preoperative and 18-month-post-operative assessments using Patient Satisfaction Score (PSS), Vancouver Scar Scale (VSS), and Patient and Observer Scar Assessment Scale (POSAS) of each group were analyzed to compare the effect of the combined therapy on outcomes...
September 20, 2016: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/28803514/investigation-sensitivity-analysis-and-multi-objective-optimization-of-effective-parameters-on-temperature-and-force-in-robotic-drilling-cortical-bone
#13
Vahid Tahmasbi, Majid Ghoreishi, Mojtaba Zolfaghari
The bone drilling process is very prominent in orthopedic surgeries and in the repair of bone fractures. It is also very common in dentistry and bone sampling operations. Due to the complexity of bone and the sensitivity of the process, bone drilling is one of the most important and sensitive processes in biomedical engineering. Orthopedic surgeries can be improved using robotic systems and mechatronic tools. The most crucial problem during drilling is an unwanted increase in process temperature (higher than 47 °C), which causes thermal osteonecrosis or cell death and local burning of the bone tissue...
August 1, 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28803363/evaluation-of-nonablative-fractional-laser-treatment-in-scar-reduction
#14
Hilal Gokalp
Fractional lasers have been used for the improvement of scar tissue in the recent years but there has not been extensive research on their impact. The purpose of this study was to evaluate the efficacy of nonablative fractional laser (NAFL) on acne, burn, and surgery/traumatic scar. The scars were also categorized as atrophic, hypertrophic, and keloid, and treatment efficacy was investigated accordingly. This is a retrospective, single-center study. Scar tissues were treated using a nonablative fractional 1550-nm Erbium glass laser in high-energy parameters at 4-week interval for 4-8 sessions...
August 12, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28803294/-barbecue-burns
#15
REVIEW
Bernd Hartmann
No abstract text is available yet for this article.
August 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/28803239/therapeutic-effect-of-0-1-tacrolimus-eye-drops-in-the-tarsal-form-of-vernal-keratoconjunctivitis
#16
Qi Wan, Jing Tang, Yu Han, Dan Wang, Hongquan Ye
OBJECTIVE: The purpose of this study was to evaluate the efficacy and safety of 0.1% tacrolimus eye drops in the tarsal form of vernal keratoconjunctivitis (VKC) and to survey the changes of dendritic cells at the palpebral conjunctiva in patients with VKC by in vivo confocal microscopy. METHODS: A total of 17 patients (34 eyes) with the tarsal form of VKC were enrolled in this prospective, nonrandomized case series. They were treated with 0.1% tacrolimus eye drops twice daily after discontinuation of all other topical medications...
August 12, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28803149/concentrations-of-polycyclic-aromatic-hydrocarbons-and-trace-elements-in-arctic-soils-a-case-study-in-svalbard
#17
Montse Marquès, Jordi Sierra, Tatiana Drotikova, Montse Mari, Martí Nadal, José L Domingo
A combined assessment on the levels and distribution profiles of polycyclic aromatic hydrocarbons (PAHs) and trace elements in soils from Pyramiden (Central Spitsbergen, Svalbard Archipelago) is here reported. As previously stated, long-range atmospheric transport, coal deposits and previous mining extractions, as well as the stack emissions of two operative power plants at this settlement are considered as potential sources of pollution. Eight top-layer soil samples were collected and analysed for the 16 US EPA priority PAHs and for 15 trace elements (As, Be, Cd, Co, Cr, Cu, Hg, Mn, Mo, Ni, Pb, Sn, Tl, V and Zn) during late summer of 2014...
August 10, 2017: Environmental Research
https://www.readbyqxmd.com/read/28802983/systemic-and-local-management-of-burn-wounds
#18
REVIEW
Alessio Vigani, Christine A Culler
Management of severe burn injury (SBI) requires prompt, complex, and aggressive care. Despite major advances in the management of SBI-including patient-targeted resuscitation, management of inhalation injuries, specific nutritional support, enhanced wound therapy, and infection control-the consequences of SBI often result in complex, multiorgan metabolic changes. Consensus guidelines and clinical evidence regarding specific management of small animal burn patients are lacking. This article aims to review updated therapeutic consideration for the systemic and local management of SBI that are proven effective to optimize outcomes in human burn patients and may translate to small animal patients...
August 9, 2017: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/28802314/aoac-smpr-%C3%A2-2017-012
#19
Anton Bzhelyansky, Gisele Atkinson, LaVerne Brown, Paul Burns, Nour Eddine Es-Safi, Christine Farthing, Adam Horkey, Holly Johnson, Adam Kuszak, Andy Lippert, Elizabeth Mudge, Tom Phillips, Klaus Reif, Catherine Rimmer, Aniko Solyom, John Szpylka, John Travis, Jinchuan Yang, Hong You, Kurt Young, Scott Coates
No abstract text is available yet for this article.
July 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28802131/food-contamination-by-pcbs-and-waste-disposal-crisis-evidence-from-goat-milk-in-campania-italy
#20
M C Ferrante, G Fusco, A Monnolo, F Saggiomo, J Guccione, R Mercogliano, M T Clausi
AIM: The study aims at investigating whether, and if so, to what extent the strong presence of urban and industrial waste in a territory may cause PCB contamination in goat milk produced therein. METHODS: We compared PCB concentrations in goat milk from three different locations in the Campania region (Italy). One of the three locations, together with its surrounding area, has long suffered from illegal waste disposal and burning mainly by the so-called Ecomafia...
July 28, 2017: Chemosphere
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