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https://www.readbyqxmd.com/read/29156854/endovascular-embolization-in-the-management-of-traumatic-and-postoperative-abdominopelvic-bleeding-a-single-center-experience
#1
Dilek Sağlam, Hasan Dinç, Abdulkadir Gündüz, Ayşegül Cansu, Mehmet Halil Öztürk
Background/aim: Endovascular embolization is widely used instead of surgery in the treatment of traumatic and postoperative abdominopelvic bleeding. The objective of this study is to evaluate the efficiency of computed tomography in the determination of active bleeding and the efficiency of endovascular embolization in traumatic and postoperative abdominopelvic bleeding. Materials and methods: Thirty-one patients admitted to our hospital with traumatic and postoperative abdominopelvic bleeding between January 2006 and September 2012 and treated with endovascular embolization were retrospectively enrolled in the study...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29156596/microvesicle-involvement-in-shiga-toxin-associated-infection
#2
REVIEW
Annie Villysson, Ashmita Tontanahal, Diana Karpman
Shiga toxin is the main virulence factor of enterohemorrhagic Escherichia coli, a non-invasive pathogen that releases virulence factors in the intestine, causing hemorrhagic colitis and, in severe cases, hemolytic uremic syndrome (HUS). HUS manifests with acute renal failure, hemolytic anemia and thrombocytopenia. Shiga toxin induces endothelial cell damage leading to platelet deposition in thrombi within the microvasculature and the development of thrombotic microangiopathy, mostly affecting the kidney. Red blood cells are destroyed in the occlusive capillary lesions...
November 19, 2017: Toxins
https://www.readbyqxmd.com/read/29156357/generation-of-complement-molecular-complex-c5b-9-c5b-9-in-response-to-poly-traumatic-hemorrhagic-shock-and-evaluation-of-c5-cleavage-inhibitors-in-non-human-primates
#3
R Madelaine Paredes, Sarah Reyna, Philip Vernon, Douglas K Tadaki, Jurandir J Dallelucca, Forest Sheppard
Severe trauma initiates a systemic inflammatory cascade and that involves early activation of complement and cleavage of C5 into C5a (anaphylatoxin) and C5b (C5b-9 membrane attack complex). We examined activation of C5 in non-human primate (NHP) models of hemorrhagic shock. Blood plasma concentrations of C5b-9 were significantly increased in NHPs in response to hemorrhage alone and were further increased with the addition of tissue trauma. The onset of increased C5 cleavage was accelerated in NHPs that experienced decompensated poly-traumatic hemorrhagic shock...
November 17, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29156155/leukotriene-b4-indicates-lung-injury-and-on-going-inflammatory-changes-after-severe-trauma-in-a-porcine-long-term-model
#4
Philipp Störmann, Birgit Auner, Lukas Schimunek, Rafael Serve, Klemens Horst, Tim-P Simon, Roman Pfeifer, Kernt Köhler, Frank Hildebrand, Sebastian Wutzler, Hans-Christoph Pape, Ingo Marzi, Borna Relja
BACKGROUND: Recognizing patients at risk for pulmonary complications (PC) is of high clinical relevance. Migration of polymorphonuclear leukocytes (PMN) to inflammatory sites plays an important role in PC, and is tightly regulated by specific chemokines including interleukin (IL)-8 and other mediators such as leukotriene (LT)B4. Previously, we have reported that LTB4 indicated early patients at risk for PC after trauma. Here, the relevance of LTB4 to indicating lung integrity in a newly established long-term porcine severe trauma model (polytrauma, PT) was explored...
December 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29156147/electromagnetic-navigational-bronchoscopy-versus-ct-guided-percutaneous-sampling-of-peripheral-indeterminate-pulmonary-nodules-a-cohort-study
#5
Kavita M Bhatt, Yasmeen K Tandon, Ruffin Graham, Charles T Lau, Jason K Lempel, Joseph T Azok, Peter J Mazzone, Erika Schneider, Nancy A Obuchowski, Michael A Bolen
Purpose To compare the diagnostic yield and complication rates of electromagnetic navigational bronchoscopic (ENB)-guided and computed tomography (CT)-guided percutaneous tissue sampling of lung nodules. Materials and Methods Retrospectively identified were 149 patients sampled percutaneously with CT guidance and 146 patients who underwent ENB with transbronchial biopsy of a lung lesion between 2013 and 2015. Clinical data, incidence of complications, and nodule pathologic analyses were assessed through electronic medical record review...
November 20, 2017: Radiology
https://www.readbyqxmd.com/read/29155884/the-importance-of-mean-time-in-therapeutic-range-for-complication-rates-in-warfarin-therapy-of-patients-with-atrial-fibrillation-a-systematic-review-and-meta-regression-analysis
#6
Anne Sig Vestergaard, Flemming Skjøth, Torben Bjerregaard Larsen, Lars Holger Ehlers
BACKGROUND: \Anticoagulation is used for stroke prophylaxis in non-valvular atrial fibrillation, amongst other by use of the vitamin K antagonist, warfarin. Quality in warfarin therapy is often summarized by the time patients spend within the therapeutic range (percent time in therapeutic range, TTR). The correlation between TTR and the occurrence of complications during warfarin therapy has been established, but the influence of patient characteristics in that respect remains undetermined...
2017: PloS One
https://www.readbyqxmd.com/read/29155823/development-and-preliminary-evaluation-of-a-multiplexed-amplification-and-next-generation-sequencing-method-for-viral-hemorrhagic-fever-diagnostics
#7
Annika Brinkmann, Koray Ergünay, Aleksandar Radonić, Zeliha Kocak Tufan, Cristina Domingo, Andreas Nitsche
BACKGROUND: We describe the development and evaluation of a novel method for targeted amplification and Next Generation Sequencing (NGS)-based identification of viral hemorrhagic fever (VHF) agents and assess the feasibility of this approach in diagnostics. METHODOLOGY: An ultrahigh-multiplex panel was designed with primers to amplify all known variants of VHF-associated viruses and relevant controls. The performance of the panel was evaluated via serially quantified nucleic acids from Yellow fever virus, Rift Valley fever virus, Crimean-Congo hemorrhagic fever (CCHF) virus, Ebola virus, Junin virus and Chikungunya virus in a semiconductor-based sequencing platform...
November 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29155697/acute-intraoperative-suprachoroidal-hemorrhage-during-small-gauge-pars-plana-vitrectomy
#8
Intira Sukpen, Jay M Stewart
PURPOSE: To report the intraoperative occurrence of acute intraoperative suprachoroidal hemorrhage during small-gauge pars plana vitrectomy. METHOD: A review of a surgical patient who developed acute intraoperative suprachoroidal hemorrhage during small-gauge pars plana vitrectomy because of bucking under general anesthesia. RESULTS: A 32-year-old obese woman with proliferative diabetic retinopathy and traction retinal detachment in the left eye who developed intraoperative suprachoroidal hemorrhage during small-gauge pars plana vitrectomy because of bucking under general anesthesia while doing endolaser under air infusion...
November 16, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29155694/paracentral-acute-middle-maculopathy-in-primary-congenital-glaucoma
#9
Yavuz K Aribas, Zeynep Aktas, Kemal Bayrakceken, Tuba Atalay, Sengul Ozdek
PURPOSE: To report a case of primary congenital glaucoma associated with paracentral acute middle maculopathy. METHODS: A case report. RESULTS: A 14-year-old girl with undiagnosed primary congenital glaucoma was referred for the evaluation of sudden vision loss a week after the initial symptoms. Visual acuity was counting fingers at 2 m in the right eye. Examination of her right eye revealed corneal stromal scar like Haab striae, splinter hemorrhage at the temporal border of the optic disk, perivenular hemorrhage, and fern-like white area at the macula...
November 16, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29155385/local-low-dose-urokinase-thrombolysis-for-the-management-of-hemodynamically-stable-pulmonary-embolism-with-right-ventricular-dysfunction
#10
Sara Alcántara Carmona, Marina Pérez Redondo, Luis Nombela Franco, Rocío González Costero, Bárbara Balandín Moreno, Miguel Valdivia de la Fuente, Santiago Méndez Alonso, Agustín García Suárez, Ana Royuela
AIMS: To evaluate the effectiveness of local low-dose urokinase thrombolysis (LLDUT) in hemodynamically stable pulmonary embolism with right ventricular dysfunction (RVD). METHODS AND RESULTS: Prospective study. LLDUT with a 200,000 IU bolus followed by a 100,000 IU/h infusion. Treatment duration was determined through radiological control performed 48-72h into treatment. Follow-up echocardiogram was performed within seven days after LLDUT completion. Evolution of thrombus burden, pulmonary artery pressures (PAP) and RVD were studied, and hemorrhagic complications and mortality were recorded...
November 21, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29155345/the-relationship-between-hematoma-and-pachymeninges-in-an-interdural-hematoma-diagnosis-and-surgical-strategy
#11
Ko-Ting Chen, Hsu-Chen Huang, Ya-Jui Lin, Ming-Houng Chen, Tsung-Che Hsieh
BACKGROUND: The exact location of a hematoma in relation to the pachymeninges contributes to typical radiographic presentations. However, because of the complexity of hematoma evolution and neomembrane formation, an unexpected intraoperative finding may lead to a change of surgical strategy. Besides, the concentration of hemoglobin and its degradation products, the integrity of red blood cells (RBCs), and the infiltration of fibroblasts, polymorphonuclear neutrophils, and macrophages are factors that affect the imaging characteristics on computed tomography (CT) and magnetic resonance imaging (MRI) as the hematoma ages...
November 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29155270/efficient-hemorrhage-control-skills-training-for-healthcare-employees
#12
Richard A Sidwell, Sarah K Spilman, Richard S Huntsman, Carlos A Pelaez
BACKGROUND: Several national initiatives are aimed at training citizens to assist bleeding victims. The purpose of this study was to evaluate an effort to quickly and efficiently teach basic bleeding control techniques to a clinical and nonclinical workforce. STUDY DESIGN: The research study was conducted at four hospitals in a mid-sized metropolitan area. In spring 2017, the trauma department at a Level 1 trauma center set an ambitious goal to provide hands-on training to 1000 employees over the course of 6 weeks...
November 16, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29155066/unruptured-versus-ruptured-avms-outcome-analysis-from-a-multicentric-consecutive-series-of-545-surgically-treated-cases
#13
Marco Cenzato, Fulvio Tartara, Giuseppe D'Aliberti, Carlo Bortolotti, Francesco Cardinale, Gianfranco Ligarotti, Alberto Debernardi, Alessia Fratianni, Edoardo Boccardi, Roberto Stefini, Francesco Zenga, Riccardo Boccaletti, Andrea Lanterna, Giacomo Pavesi, Paolo Ferroli, Carmelo Sturiale, Alessandro Ducati, Andrea Cardia, Maurizio Piparo, Luca Valvassori, Mariangela Piano
Recent literature strongly challenged indications to perform preventive surgery in unruptured AVM. claiming that invasive AVM treatment is associated with a significant risk of complications and thus conservative management may be a preferable alternative in many patients. On the other hand, the recent improvement of surgical instrumentation and treatment strategies (both surgical and interventional) yielded much better outcomes than those achieved only a decade ago. Therefore, even among the specialists, a wide variety of opinions, concerning the treatment of unruptured AVM, can be found...
November 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29154937/effect-of-human-recombinant-prourokinase-rhpro-uk-on-thromboembolic-stroke-in-rats
#14
Chun-Hua Hao, Wen-Xia Ding, Qian Sun, Xin-Xin Li, Wei-Ting Wang, Zhuan-You Zhao, Li-da Tang
We evaluated the efficacy and safety of human recombinant prourokinase ( rhpro-UK) on thromboembolic stroke in rats. 60 rats with thromboembolic stroke were divided into 6 groups(n=10). The model group was given saline, the reagent groups were given rhpro-UK (5, 10, 20×10(4) U/kg), and positive control groups were given urokinase (UK) 10×10(4) U/kg and recombinant tissue plasminogen activator (rt-PA) 9mg/kg through intravenous infusion at 1.5h after embolism. And other 10 rats without occluded by autologous blood clots as the sham group were given saline...
November 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29154839/participation-of-the-anti-inflammatory-and-antioxidative-activity-of-docosahexaenoic-acid-on-indomethacin-induced-gastric-injury-model
#15
Elizabeth Arlen Pineda-Peña, Yoalli Martínez-Pérez, Marina Galicia-Moreno, Araceli Navarrete, José Segovia, Pablo Muriel, Liliana Favari, Gilberto Castañeda-Hernández, Aracely Evangelina Chávez-Piña
Adverse gastrointestinal (GI) effects caused by nonsteroidal anti-inflammatory drugs (NSAIDs), including indomethacin, are recognized as the major limitation to their clinical use. NSAID-induced gastric damage is generated by cyclooxygenase inhibition, activation of inflammatory processes, and oxidative stress. Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, has shown gastroprotective effects; however, the molecular mechanisms underlying these effects have not been fully explained. As a result, the aim of this study was to examine DHA's anti-inflammatory and antioxidative actions in a mouse model of indomethacin-induced gastric injury...
November 14, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29154774/recommendations-for-care-of-geriatric-maxillofacial-trauma-patients-following-a-retrospective-10-year-multicenter-review
#16
Robert Shumate, Jason Portnof, Melissa Amundson, Eric Dierks, Robert Batdorf, Patrick Hardigan
PURPOSE: The purpose of this study was to analyze maxillofacial trauma sustained by patients at least 75 years old. With the injury patterns identified, treatment recommendations for the contemporary oral and maxillofacial surgeon are made. PATIENTS AND METHODS: This study was a retrospective case series using data from 2 level 1 trauma centers. The variables of interest included age at traumatic event, gender, mechanism of trauma, concomitant injuries, radiographic studies performed, management of maxillofacial injuries, and disposition...
October 26, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29154751/the-etiology-of-spontaneous-intracerebralhemorrhage-insights-from-a-neuropathological-series
#17
Luis Ruano, Mariana Branco, Raquel Samões, Ricardo Taipa, Manuel Melo Pires
The etiology of intracerebral hemorrhage (ICH) is frequently undetermined. We aimed to assess the impact of the neuropathological study on the etiologic diagnosis of ICH. Patients with ICH admitted to a tertiary hospital in the last 14 years were identified, and histological samples of surgically-drained ICH were retrieved. Blinded from neuropathological results, a clinical etiology was hypothesized. Pathological samples were reviewed, and immunohistochemistry study for β-amyloid was performed in all the cases where structural abnormalities were not identified...
November 20, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/29154725/non-aneurysmal-subarachnoid-hemorrhage-when-is-a-second-angiography-indicated
#18
Asma Bashir, Ronni Mikkelsen, Leif Sørensen, Niels Sunde
Purpose Repeat imaging in patients with non-aneurysmal subarachnoid hemorrhage (NASAH) remains controversial. We aim to report our experience with NASAH with different hemorrhage patterns, and to investigate the need for further diagnostic workup to determine the underlying cause of hemorrhage. Method We conducted a retrospective analysis of all spontaneous SAH with an initial negative computed tomography (CT) with angiography (CTA) and/or digital subtraction angiography (DSA) from October 2011 through May 2017...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/29154015/albumin-bilirubin-grade-versus-meld-score-for-predicting-survival-after-transjugular-intrahepatic-portosystemic-shunt-tips-creation
#19
J Ronald, Q Wang, S S Choi, P V Suhocki, M D Hall, T P Smith, C Y Kim
OBJECTIVES: The purpose of this study was to compare the albumin-bilirubin (ALBI) grade and model for end-stage liver disease (MELD) scores for predicting survival after transjugular intrahepatic portosystemic shunt (TIPS) creation. MATERIALS AND METHODS: A retrospective study of pre-procedure ALBI and MELD scores was performed in 197 patients who underwent TIPS from 2005 to 2012. There were 140 men and 57 women, with a mean age of 56±11 (SD) (range: 19-90years)...
November 16, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29153952/surveillance-of-the-safety-and-efficacy-of-recombinant-human-soluble-thrombomodulin-in-patients-with-obstetrical-disseminated-intravascular-coagulation
#20
Takao Kobayashi, Masahiro Kajiki, Katsuhito Nihashi, Goichi Honda
BACKGROUND: Recombinant human soluble thrombomodulin (TM-α) has been shown to be useful in the treatment of disseminated intravascular coagulation (DIC) in a heparin-controlled study, and has been available for clinical use in Japan since 2008. However, use of TM-α for obstetrical DIC has not yet been established, so efficacy and safety were analyzed in 117 obstetrical DIC patients identified from post-marketing surveillance. MATERIALS AND METHODS: From June 2010 to March 2012, the cases of 117 patients with obstetrical DIC treated with TM-α were registered...
September 18, 2017: Thrombosis Research
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