keyword
https://read.qxmd.com/read/38536934/attenuation-of-fibroblast-activation-and-fibrosis-by-adropin-in-systemic-sclerosis
#1
JOURNAL ARTICLE
Minrui Liang, Nicholas Dickel, Andrea-Hermina Györfi, Bilgesu SafakTümerdem, Yi-Nan Li, Aleix Rius Rigau, Chunguang Liang, Xuezhi Hong, Lichong Shen, Alexandru-Emil Matei, Thuong Trinh-Minh, Cuong Tran-Manh, Xiang Zhou, Ariella Zehender, Alexander Kreuter, Hejian Zou, Georg Schett, Meik Kunz, Jörg H W Distler
Fibrotic diseases impose a major socioeconomic challenge on modern societies and have limited treatment options. Adropin, a peptide hormone encoded by the energy homeostasis-associated ( ENHO ) gene, is implicated in metabolism and vascular homeostasis, but its role in the pathogenesis of fibrosis remains enigmatic. Here, we used machine learning approaches in combination with functional in vitro and in vivo experiments to characterize adropin as a potential regulator involved in fibroblast activation and tissue fibrosis in systemic sclerosis (SSc)...
March 27, 2024: Science Translational Medicine
https://read.qxmd.com/read/38536894/the-effects-of-dental-hygienist-autonomy-on-dental-care-utilization
#2
JOURNAL ARTICLE
Jie Chen, Chad D Meyerhoefer, Edward J Timmons
We investigate the effects of regulations governing the practice autonomy of dental hygienists on dental care use with the 2001-2014 Medical Expenditure Panel Survey. We measure the strength of autonomy regulations by extending the Dental Hygiene Professional Practice Index to the years 2001-2014, allowing us to capture changes in regulations within states over time. Using a difference-in-differences framework applied to selected states, we find that relaxing supervision requirements to provide dental hygienists moderate autonomy results in an increase in total dental visits due to greater use of preventive dental care...
March 27, 2024: Health Economics
https://read.qxmd.com/read/38536622/electronic-health-records-for-predicting-outcomes-to-work-related-musculoskeletal-disorders-a-scoping-review
#3
REVIEW
M Wassell, A Vitiello, K Butler-Henderson, K Verspoor, P McCann, H Pollard
PURPOSE: Through electronic health records (EHRs), musculoskeletal (MSK) therapists such as chiropractors and physical therapists, as well as occupational medicine physicians could collect data on many variables that can be traditionally challenging to collect in managing work-related musculoskeletal disorders (WMSDs). The review's objectives were to explore the extent of research using EHRs in predicting outcomes of WMSDs by MSK therapists. METHOD: A systematic search was conducted in Medline, PubMed, CINAHL, and Embase...
March 27, 2024: Journal of Occupational Rehabilitation
https://read.qxmd.com/read/38536526/pharmacological-and-immunomodulatory-modes-of-action-of-medically-important-phytochemicals-against-arthritis-a-molecular-insight
#4
REVIEW
Aqsa, Shaukat Ali, Muhammad Summer, Saima Yousaf, Laiba Nazakat, Shehzeen Noor
Arthritis is a common illness that affects joints and it may result in inflammation and pain. Even though arthritis usually affects older people, it can also affect children, adults, and both genders. Numerous arthritic mouse models have been developed but the CIA model of rheumatoid arthritis (RA) has received the most attention. With the use of steroids, DMARDs, and NSAIDs, therapy objectives such as reduced disease incidence and better pain management are achieved. Long-term usage of these therapeutic approaches may have negative side effects...
March 27, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38536512/potential-role-of-immune-cell-therapy-in-gynecological-cancer-and-future-promises-a-comprehensive-review
#5
REVIEW
Sandipan Dasgupta, Sakuntala Gayen, Tania Chakraborty, Naureen Afrose, Ranita Pal, Sutapa Mahata, Vilas Nasare, Souvik Roy
Gynecological malignancies are most leading causes of death among women worldwide. The high prevalence of gynecologic malignancies remains significant, necessitating to turn the novel treatment approach like immunotherapy, wherein cancer cells are killed by the invasion of immune system. In recent year, immunotherapy has mostly an advanced treatment approach to repressing the tumor cells survival, proliferation, and invasion via the activation of immune systems. Moreover, various types of immune cells including T-cells, B-cells, and dendritic cells are associated with the immunotherapeutic strategy in cancer treatment...
March 27, 2024: Medical Oncology
https://read.qxmd.com/read/38536220/benchmarking-mental-health-status-using-passive-sensor-data-protocol-for-a-prospective-observational-study
#6
JOURNAL ARTICLE
Robyn E Kilshaw, Abigail Boggins, Olivia Everett, Emma Butner, Feea R Leifker, Brian R W Baucom
BACKGROUND: Computational psychiatry has the potential to advance the diagnosis, mechanistic understanding, and treatment of mental health conditions. Promising results from clinical samples have led to calls to extend these methods to mental health risk assessment in the general public; however, data typically used with clinical samples are neither available nor scalable for research in the general population. Digital phenotyping addresses this by capitalizing on the multimodal and widely available data created by sensors embedded in personal digital devices (eg, smartphones) and is a promising approach to extending computational psychiatry methods to improve mental health risk assessment in the general population...
March 27, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38535535/feline-chronic-gingivostomatitis-diagnosis-and-treatment-through-transcriptomic-insights
#7
Maria Soltero-Rivera, Claire Shaw, Boaz Arzi, Milinda Lommer, Bart C Weimer
Feline chronic gingivostomatitis (FCGS) is a debilitating inflammatory oral mucosal disease with a multifactorial etiology. The clinical diagnosis of FCGS is made based on inspection of severe inflammatory lesions and histological confirmation rather than a molecular diagnostic outcome. This gap limits the ability to provide an early diagnosis. In this report, we seek to provide additional diagnostic tools using genomics to aid in providing clinically relevant information. The use of in-depth diagnostic tools, like transcriptomics of diseased tissues, to diagnose FCGS and stratify patients into predictive treatment response groups would dramatically improve both clinical decisions and patient outcomes...
February 21, 2024: Pathogens
https://read.qxmd.com/read/38535503/medical-expectations-of-physicians-on-ai-solutions-in-daily-practice-cross-sectional-survey-study
#8
JOURNAL ARTICLE
Mara Giavina-Bianchi, Edson Amaro, Birajara Soares Machado
BACKGROUND: The use of artificial intelligence (AI) in medicine has been a trending subject in the past few years. Although not frequently used in daily practice yet, it brings along many expectations, doubts, and fears for physicians. Surveys can be used to help understand this situation. OBJECTIVE: This study aimed to explore the degree of knowledge, expectations, and fears on possible AI use by physicians in daily practice, according to sex and time since graduation...
March 25, 2024: JMIRx med
https://read.qxmd.com/read/38534802/temporal-considerations-in-brain-metastases-radiation-therapy-the-intersection-of-chronobiology-and-patient-profiles
#9
JOURNAL ARTICLE
Nicolas G Nelson, Sara E Burke, Louis Cappelli, Lauren E Matlack, Alexandria P Smith, Noelle Francois, Joseph F Lombardo, Yash B Shah, Kuang-Yi Wen, Ayesha A Shafi, Nicole L Simone
The circadian system, a vital temporal regulator influencing physiological processes, has implications for cancer development and treatment response. Our study assessed circadian timing's impact on whole-brain radiotherapy outcomes in brain metastases for personalized cancer therapy insights. The aim of the study was to evaluate circadian influence on radiation treatment timing and its correlation with clinical outcomes and to identify patient populations benefiting from interventions synchronizing circadian rhythms, considering subgroup differences and potential disparities...
March 21, 2024: Clocks & Sleep
https://read.qxmd.com/read/38534787/unveiling-the-molecular-mechanism-of-trastuzumab-resistance-in-skbr3-and-bt474-cell-lines-for-her2-positive-breast-cancer
#10
JOURNAL ARTICLE
Anna Kokot, Sachin Gadakh, Indrajit Saha, Ewa Gajda, Michał Łaźniewski, Somnath Rakshit, Kaustav Sengupta, Ayatullah Faruk Mollah, Michał Denkiewicz, Katarzyna Górczak, Jürgen Claesen, Tomasz Burzykowski, Dariusz Plewczynski
HER2-positive breast cancer is one of the most prevalent forms of cancer among women worldwide. Generally, the molecular characteristics of this breast cancer include activation of human epidermal growth factor receptor-2 (HER2) and hormone receptor activation. HER2-positive is associated with a higher death rate, which led to the development of a monoclonal antibody called trastuzumab, specifically targeting HER2. The success rate of HER2-positive breast cancer treatment has been increased; however, drug resistance remains a challenge...
March 21, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534739/ferroptosis-related-lncrna-to-predict-the-clinical-outcomes-and-molecular-characteristics-of-kidney-renal-papillary-cell-carcinoma
#11
JOURNAL ARTICLE
Yubo Gong, Chenchen Zhang, Hao Li, Xiaojie Yu, Yuejia Li, Zhiguo Liu, Ruyi He
Kidney renal papillary cell carcinoma (KIRP) is a highly heterogeneous type of kidney cancer, resulting in limited effective prognostic targets for KIRP patients. Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in the regulation of ferroptosis and iron metabolism, making them potential targets for the treatment and prognosis of KIRP. In this study, we constructed a ferroptosis-related lncRNA risk score model (FRM) based on the TCGA-KIRP dataset, which represents a novel subtype of KIRP not previously reported...
February 29, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534315/cisplatin-and-starvation-differently-sensitize-autophagy-in-renal-carcinoma-a-potential-therapeutic-pathway-to-target-variegated-drugs-resistant-cancerous-cells
#12
JOURNAL ARTICLE
Ankita Dutta, Subarna Thakur, Debasish Kumar Dey, Anoop Kumar
Cisplatin, a powerful chemotherapy medication, has long been a cornerstone in the fight against cancer due to chemotherapeutic failure. The mechanism of cisplatin resistance/failure is a multifaceted and complex issue that consists mainly of apoptosis inhibition through autophagy sensitization. Currently, researchers are exploring ways to regulate autophagy in order to tip the balance in favor of effective chemotherapy. Based on this notion, the current study primarily identifies the differentially expressed genes (DEGs) in cisplatin-treated autophagic ACHN cells through the Illumina Hi-seq platform...
March 7, 2024: Cells
https://read.qxmd.com/read/38533968/genetic-modulation-of-biosynthetic-gas-vesicles-for-ultrasound-imaging
#13
JOURNAL ARTICLE
Meijun Fu, Yuanyuan Wang, Jieqiong Wang, Yongsheng Hao, Fengyi Zeng, Zhaomeng Zhang, Jianxiong Du, Huan Long, Fei Yan
Gas vesicles (GVs) from microorganisms are genetically air-filled protein nanostructures, and serve as a new class of nanoscale contrast agents for ultrasound imaging. Recently, the genetically encoded GV gene clusters have been heterologously expressed in Escherichia coli, allowing these genetically engineered bacteria to be visualized in vivo in a real-time manner by ultrasound. However, most of the GV genes remained functionally uncharacterized, which makes it difficult to regulate and modify GVs for broad medical applications...
March 27, 2024: Small
https://read.qxmd.com/read/38532256/interoceptive-sensibility-intuitive-eating-binge-and-disordered-eating-behavior-among-individuals-with-obesity-a-comparative-study-with-the-general-population
#14
JOURNAL ARTICLE
Vrutti Joshi, Pierluigi Graziani, Jonathan Del-Monte
The present study assessed the links between interoceptive sensibility, binge, disordered (emotional, restrained, and external) and intuitive eating among individuals with obesity ( n  = 57) and normal weight ( n  = 29). Individuals with obesity presented lower "attention regulation," "body-listening," and "trusting" interoceptive dimensions. When age was controlled, group differences on "trusting" remained significant. Individuals with obesity showed lower intuitive eating, higher emotional, and binge eating compared to controls...
March 26, 2024: Journal of Health Psychology
https://read.qxmd.com/read/38531432/the-chemometrics-analysis-and-integrated-pharmacology-approach-to-decipher-the-effect-and-mechanism-between-raw-and-processed-cistanche-tubulosa
#15
JOURNAL ARTICLE
Xing-Yue Zhang, Qi-Wu Jiang, Su-Han Yang, Ping Li, Zhi-Yong Chang, Fei Li
ETHNOPHARMACOLOGICAL RELEVANCE: Cistanche tubulosa (CT) is the dried fleshy stem with scaly leaves of Cistanche tubiflora (Schenk) Wight, which has the effects of tonifying the kidney-yang, benefiting the vital essence and blood, and moisturizing the intestines and laxatives. There are differences in the activity of CT before and after processing, but the mechanism of processing is not clear. AIM OF THE STUDY: The study aimed to compare the strength of action of CT before and after yellow-wine processing in the treatment of constipation and kidney yang deficiency and to identify the active ingredients responsible for the differences in activity before and after yellow-wine processing...
March 24, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38531161/functional-and-structural-effects-of-repetitive-transcranial-magnetic-stimulation-rtms-for-the-treatment-of-auditory-verbal-hallucinations-in-schizophrenia-a-systematic-review
#16
REVIEW
Dhvani D Mehta, Salsabil Siddiqui, Heather B Ward, Vaughn R Steele, Godfrey D Pearlson, Tony P George
BACKGROUND: Auditory verbal hallucinations (AVH) are a disabling symptom for people with schizophrenia (SCZ), and do not always respond to antipsychotics. Repetitive transcranial magnetic stimulation (rTMS) has shown efficacy for medication-refractory AVH, though the underlying neural mechanisms by which rTMS produces these effects remain unclear. This systematic review evaluated the structural and functional impact of rTMS for AVH in SCZ, and its association with clinical outcomes. METHODS: A systematic search was conducted in Medline, PsychINFO, and PubMed using terms for four key concepts: AVH, SCZ, rTMS, neuroimaging...
March 25, 2024: Schizophrenia Research
https://read.qxmd.com/read/38530121/gray-matter-volume-associations-in-youth-with-adhd-features-of-inattention-and-hyperactivity-impulsivity
#17
JOURNAL ARTICLE
Gabrielle E Reimann, Hee Jung Jeong, E Leighton Durham, Camille Archer, Tyler M Moore, Fanual Berhe, Randolph M Dupont, Antonia N Kaczkurkin
BACKGROUND: Prior research has shown smaller cortical and subcortical gray matter volumes among individuals with attention-deficit/hyperactivity disorder (ADHD). However, neuroimaging studies often do not differentiate between inattention and hyperactivity/impulsivity, which are distinct core features of ADHD. The present study uses an approach to disentangle overlapping variance to examine the neurostructural heterogeneity of inattention and hyperactivity/impulsivity dimensions. METHODS: We analyzed data from 10,692 9- to 10-year-old children from the Adolescent Brain Cognitive Development (ABCD) Study...
April 2024: Human Brain Mapping
https://read.qxmd.com/read/38530108/lifecycle-of-surgical-devices-global-environmental-and-regulatory-considerations
#18
JOURNAL ARTICLE
Eric R Wahlstedt, John C Wahlstedt, Jenna S Rosenberg, Catherine R deVries
BACKGROUND: Technological advancements, improved surgical access, and heightened demand for surgery have fueled unprecedented device and supply turnover impelling wealthy hospitals to upgrade continually and sell, donate, recycle, or dispose of used, expired, antiquated, or surplus goods. This paper reviews the issues related to device and supply lifecycles and discusses the opportunities and challenges they present for sustainable surgical growth in low- and middle-income (LMICs) countries...
March 26, 2024: World Journal of Surgery
https://read.qxmd.com/read/38530015/hypomethylation-of-the-lncrna-h19-promoter-accelerates-osteogenic-differentiation-of-vascular-smooth-muscle-cells-by-activating-the-erk1-2-pathways
#19
JOURNAL ARTICLE
Taoxia Wang, Meijuan Cheng, Jingjing Jin, Yaling Bai, Dongxue Zhang, Shenglei Zhang, Jinsheng Xu
OBJECTIVE: Vascular calcification is a common chronic kidney disease complication. This study aimed to investigate the function of long non-coding RNA (LncRNA) H19 in vascular calcification to explore new therapeutic strategies. METHODS: We induced osteogenic differentiation and calcification of vascular smooth muscle cells (VSMCs) using β-glycerophosphate. Then, we detected the LncRNA H19 promoter methylation status and Erk1/2 pathways using methylation-specific polymerase chain reaction and western blotting, respectively...
March 2024: Journal of International Medical Research
https://read.qxmd.com/read/38529886/disp1-deficiency-monoallelic-and-biallelic-variants-cause-a-spectrum-of-midline-craniofacial-malformations
#20
JOURNAL ARTICLE
Alinoë Lavillaureix, Paul Rollier, Artem Kim, Veranika Panasenkava, Marie De Tayrac, Wilfrid Carré, Hélène Guyodo, Marie Faoucher, Elisabeth Poirel, Linda Akloul, Chloe Quelin, Sandra Whalen, Jessica Bos, Marjoleine Broekema, Johanna M van Hagen, Katheryn Grand, Michelle Allen-Sharpley, Emily Magness, Scott McLean, Hülya Kayserili, Umut Altunoglu, Angie En Qi Chong, Shifeng Xue, Mederic Jeanne, Naif Almontashiri, Wisam Habhab, Clemence Vanlerberghe, Laurence Faivre, Eleonore Viora Dupont, Christophe Philippe, Hana Safraou, Fanny Laffargue, Luisa Mittendorf, Rami Abou Jamra, Siddaramappa Jagdish Patil, Ashwin Dalal, Asodu Sandeep Sarma, Boris Keren, Bruno Reversade, Christèle Dubourg, Sylvie Odent, Valérie Dupé
PURPOSE: DISP1 encodes a transmembrane protein that regulates the secretion of the morphogen, Sonic hedgehog (SHH), a deficiency of which is a major cause of holoprosencephaly (HPE). This disorder covers a spectrum of brain and midline craniofacial malformations. The objective of the present study was to better delineate the clinical phenotypes associated with DISP1 variants. METHODS: This study was based on the identification of at least one pathogenic variant of the DISP1 gene in individuals for whom detailed clinical data were available...
March 23, 2024: Genetics in Medicine: Official Journal of the American College of Medical Genetics
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