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JOURNAL ARTICLE
Matthew S Perzanowski, Virginia Rauh, Bruce Ramphal, Luis Acosta, Lori Hoepner, Andrew G Rundle, Frederica P Perera, Julie Herbstman, Rachel L Miller, Amy E Margolis
Increased parasympathetic nervous system (PNS) activity is associated with attention-deficit/hyperactivity disorder (ADHD) inattentive symptoms, but not hyperactive-impulsive symptoms, and may contribute to inattentive subtype etiology. Guided by prior work linking infant rhinorrhea and watery eyes without a cold (RWWC) to PNS dysregulation, we examined associations between infant RWWC and childhood ADHD symptoms in a longitudinal cohort of Black and Latinx children living in the context of economic disadvantage (N = 301 youth: 158 females, 143 males)...
July 2024: Developmental Psychobiology
#22
JOURNAL ARTICLE
Minghui Tao, Yanping Zhang, Ling Ding, Donghong Peng
BACKGROUND: Sleep-disordered breathing (SDB) may lead to poor asthma control in children. OBJECTIVE: To identify risk factors of SDB in children with asthma and assess its impact on asthma control. METHODS: In this cross-sectional study, we collected data of outpatients with asthma at the Children's Hospital of Chongqing Medical University from June 2020 to August 2021. The Pediatric Sleep Questionnaire-Sleep-Related Breathing Disorder and the age-appropriate asthma control tests Childhood Asthma Control Test and Test for Respiratory and Asthma Control in Kids were completed...
April 30, 2024: BMC Pediatrics
#23
JOURNAL ARTICLE
Xue Li, Juju Shang, Jian Liu, Yong Zhu
Background: This meta-analysis aimed to evaluate the effectiveness and adverse effects of specific immunotherapy (SIT) in the management of respiratory allergens, including allergic asthma, rhinitis, and related disorders, based on a review of current literature up to November 8, 2022. Methods: We conducted a search of databases, including PubMed, Embase, Cochrane, and Web of Science, to identify relevant randomized controlled trials (RCTs) assessing respiratory allergy-specific immunotherapy. We employed the Consolidated Standards of Reporting Trials (CONSORT) Statement to select RCTs that adhered to rigorous reporting standards...
April 30, 2024: Journal of Asthma
#24
JOURNAL ARTICLE
Phuntila Tharabenjasin, Aekkacha Moonwiriyakit, Jenjira Sontikun, Kanokphorn Timpratueang, Suhaibee Kuno, Thitinan Aiebchun, Nathjanan Jongkon, Rungrawee Mongkolrob, Noel Pabalan, Kiattawee Choowongkomon, Chatchai Muanprasat
Allergic inflammation, which is the pathogenesis of allergic rhinitis and asthma, is associated with disruption of the airway epithelial barrier due to the effects of type 2 inflammatory cytokines, i.e. interleukin-4 and interleukin-13 (IL-4/13). The anti-allergic inflammatory effect of β-eudesmol (BE) on the tight junction (TJ) of the airway epithelium has not previously been reported. Herein, the barrier protective effect of BE was determined by measurement of transepithelial electrical resistance and by paracellular permeability assay in an IL-4/13-treated 16HBE14o- monolayer...
2024: PloS One
#25
JOURNAL ARTICLE
Sampo Kallio, Ching Jian, Katri Korpela, Anna Kaarina Kukkonen, Anne Salonen, Erkki Savilahti, Mikael Kuitunen, Willem M de Vos
Perinatal and early-life factors reported to affect risk of allergic diseases may be mediated by changes in the gut microbiota. Here, we explored the associations between the infant gut microbiota and allergic morbidity in childhood until 13 years of age in a subgroup of the FLORA probiotic intervention cohort. A mixture of four probiotic strains with galacto-oligosaccharides was administrated to the mothers from the 36th week of the pregnancy and later to their infants until 6 months of age. The infants were monitored for the manifestations of atopic eczema, food allergy, allergic rhinitis, and asthma by a pediatrician at 2 and 5 years of age; the allergic status was subsequently verified by a questionnaire at 10 and 13 years of age...
April 30, 2024: Microbiology Spectrum
#26
REVIEW
Peter Socrates Creticos, Fatma E Gunaydin, Hendrik Nolte, Cecilia Damask, Stephen R Durham
Allergen immunotherapy is a recognized key therapeutic modality for the treatment of allergic respiratory disease - definitive studies have provided evidence-based data to demonstrate its effectiveness in allergic rhinitis and asthma due to the inhalation of proteinaceous allergic substances from specific seasonal pollens, dust mites, animal allergens, and certain mold spores. Over the ensuing decades, laboratory investigations, have provided objective evidence to demonstrate immunologic changes, including production of protective IgG antibody, suppression of IgE antibody, upregulation of regulatory T-cells, and an induction of a state of immune tolerance to the offending allergen(s)...
April 27, 2024: Journal of Allergy and Clinical Immunology in Practice
#27
JOURNAL ARTICLE
Oscar Manuel Calderón-Llosa
OBJECTIVE: To identify and registry the most important fungal spores trapped in our aerobiology station, as well as to report the prevalence of skin sensitization to these allergens. METHODS: The pollen counts were made according to standardized technique with a Burkard seven days spore trap, following the American Academy of Allergy, Asthma and Immunology (AAAAI) through National Allergy Bureau (NAB) recommendations. The trap was installed on the roof of Clinica SANNA, El GOLF, San Isidro, which is 20 m high, 12°5'54"S 77°3'6"W in the west-south of the Lima urban area...
February 1, 2024: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
#28
JOURNAL ARTICLE
Sergio Londoño, Juan Carlos Penagos, Diana Díaz, Pedro Cadena, Paula Rodríguez Ordoñez
OBJECTIVE: To present the baseline clinical and demographic characteristics of CRSwNP patients over the age of 18 enrolled in a Patient Support Program (PSP) prior to biologic treatment. METHODS: Descriptive, cross-sectional study performed in a Colombian CRSwNP asthma PSP sponsored by Sanofi from Aug-2021 to Jul-2022. Data was collected from CRSwNP patients, prior to the start of Dupilumab treatment, who consented to the use of their data. The following information was reported: Age, reporting city, treating medical specialty, comorbidities, and persistence of treatment...
February 1, 2024: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
#29
JOURNAL ARTICLE
Iván Tinoco-Moran, Oscar Calderón-Liosa, Margarita Olivares-Gómez, Victor Farinango-Salazar, Iván Chérrez-Ojeda
BACKGROUND: Anaphylaxis is a severe systemic allergic reaction that can be life-threatening, timely diagnosis and treatment is required in these patients, one of the most frequent triggers is pharmacological. OBJECTIVE: To report the case of a patient who presented anaphylaxis due to eye drops. CASE REPORT: A 7-year-old male with a history of rhinitis and asthma with good control. It started with itchy eyes, ophthalmic drops were administered, composition: Polyethylene glycol 400, 0...
February 1, 2024: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
#30
JOURNAL ARTICLE
Oscar Calderón, Denisse Cevallos, Germán Ramón, Laura Barrionuevo, Karla Robles, Iván Tinoco, Iván Chérrez
OBJETIVO: To identify and registry the most important aeroallergens trapped at the aerobiology station in the city of Samborondon, Ecuador. METHODS: Pollen grains and fungal spore counts were performed according to the standardized technique with a Hirst-type collection equipment, Burkard spore trap for seven days, following the recommendations of the National Allergy Bureau (NAB) of the American Academy of Allergy Asthma and Immunology (AAAAI). The equipment was installed on the roof of the Universidad de Especialidades Espiritu Santo (UEES), 25 m above ground level, coordinates: 2°07 ́57 ́ ́S 79°52 ́06 ́ ́W, in the city of Samborondon...
February 1, 2024: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
#31
JOURNAL ARTICLE
Haijing Sui, Hong Shen, Chi Zhang, Minghui Wang, Zhen Zhen, Junbo Zhang
OBJECTIVE: This study aimed to explore whether saliva pepsin concentration (SPC) could be regarded as a risk factor for the occurrence and unfavorable control of asthma in children with allergic rhinitis. METHODS: A prospective study was conducted on a group of 20 consecutive children newly diagnosed with allergic rhinitis and asthma (referred to as the asthma group). All these children underwent fractional exhaled nitric oxide (FeNO) measurement, lung function tests, and assessment of asthma control using the 7-item Childhood Asthma Control Test (C-ACT) score...
2024: Journal of Asthma and Allergy
#32
REVIEW
Shaimaa AlBloushi, Mona Al-Ahmad
Significant advancements have been achieved in understanding the roles of different immune cells, as well as cytokines and chemokines, in the pathogenesis of eosinophilic airway conditions. This review examines the pathogenesis of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP), marked by complex immune dysregulation, with major contributions from type 2 inflammation and dysfunctional airway epithelium. The presence of eosinophils and the role of T-cell subsets, particularly an imbalance between Treg and Th17 cells, are crucial to the disease's pathogenesis...
2024: Frontiers in Immunology
#33
JOURNAL ARTICLE
A G Adekanye, B C Onwughalu, R B Mgbe, Anu Umana, C O Anisi, A O Somefun
BACKGROUND: Predisposing factors for otitis media with effusion are multifactorial, ranging from genetic and anatomical abnormalities to environmental factors and inflammation of the nose and adjacent structures. AIM: The study determined the risk factors for otitis media with effusion (OME) among children in Calabar Municipality. METHODS: This was a descriptive, cross-sectional, community-based study including children aged 1-10 years randomly selected from government and privately owned daycares, nurseries (preschool), and primary schools...
April 1, 2024: Nigerian Journal of Clinical Practice
#34
JOURNAL ARTICLE
Maria V Dimou, Paraskevi Xepapadaki, John Lakoumentas, Leonardos Mageiros, Xenophon Aggelidis, Maria Antonopoulou, Petros Bakakos, Sophia Βotskariova, Konstantinos Chliveros, Spyridon Chrysoulakis, Dionysios Dimas, Nikolaos Douladiris, Mina Gaga, Christos Grigoreas, Lampros Kalogiros, Michael Katotomichelakis, Evangelia Kompoti, Jannis Constantinidis, Zoi Koutsogianni, Stelios Loukides, Michael Makris, Emmanouil Manousakis, Pavlos Marangoudakis, Maria Marmara, Nikolaos Mikos, Paraskevi Mitsakou, Dimitrios Mitsias, Aris Pagalos, Vasilios Papanikolaou, Ioannis Paraskevopoulos, Constantinos Pitsios, Fotis Psarros, Nikoletta Rovina, Konstantinos Samitas, Evaggelia Stefanaki, Mina Vallianatou, Dimitrios Vourdas, Ioanna Tsiligianni, Jean Bousquet, Nikolaos G Papadopoulos
BACKGROUND: Allergic rhinitis (AR) is a common respiratory disease encompassing a variety of phenotypes. Patients can be sensitized to one or more allergens. There are indications that polysensitization is associated with more severe disease. However, the extent to which the level of sensitization is associated to clinical disease variability, underlying the distinct nature of AR from AR+ conjunctivitis or AR+ asthma, is not known. OBJECTIVE: The aim of this study was to evaluate phenotypical differences between mono- and poly-sensitized patients with AR and to quantify their symptomatic variability...
April 26, 2024: Annals of Allergy, Asthma & Immunology
#35
JOURNAL ARTICLE
Sophie Scheire, Sophie Germonpré, Els Mehuys, Inge Van Tongelen, An De Sutter, Stephane Steurbaut, Thierry Van Hees, Sophie Demarche, Lies Lahousse, Philippe Gevaert, Koen Boussery
BACKGROUND: Little is known about rhinitis control in real-life, nor about the contribution of treatment-related and patient-related factors. OBJECTIVE: This study aimed to examine the level of rhinitis control and rhinitis medication utilization in patients with persistent rhinitis, and to identify predictors of rhinitis control. METHODS: A cross-sectional observational study was conducted in patients with persistent rhinitis recruited in community pharmacies...
April 25, 2024: Journal of Allergy and Clinical Immunology in Practice
#36
JOURNAL ARTICLE
Jean Bousquet, Alina Gherasim, Frédéric de Blay, Eve Mathieu-Dupas, Géraldine Batot, Daniel Laune, Bernardo Sousa-Pinto, Torsten Zuberbier, Nhân Pham-Thi
BACKGROUND: An innovation to better manage cat-allergic patients utilises anti-Fel d 1 IgY antibodies to neutralise Fel d 1 after its production by the cat. However, there is no published study showing its clinical efficacy in humans in a home setting. A longitudinal, open-label, proof-of-concept study was carried out to approach clinical efficacy of the cat food in cat-allergic patients. METHODS: After a baseline evaluation, the cats ate only the cat food for the following 4 months...
May 2024: Clinical and Translational Allergy
#37
MULTICENTER STUDY
Gülfem Elif Çelik, Ömür Aydin, Elif Şen, Tunçalp Demir, Bilun Gemicioğlu, Esen Kiyan, Dilşad Mungan, İpek Kivilcim Oğuzülgen, Mehmet Polatli, Özlem Göksel, Abdullah Sayiner, Nurhayat Yildirim, Füsun Yildiz, Arzu Yorgancioğlu, Atilla Halil Elhan, Öznur Yildiz, İlknur Başyiğit, Şermin Börekçi, Yavuz Havlucu, Gülfer Okumuş, Murat Türk, Sevgi Saryal
INTRODUCTION: Patients with asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) have a greater disease burden than those with COPD or asthma alone. In this study, it was aimed to determine the prevalence, risk factors, and clinical features of ACO because there are limited national data in Türkiye. MATERIALS AND METHODS: The study was conducted in a cross-sectional design in nine tertiary-care hospitals. The patients followed with a diagnosis of asthma or COPD for at least one year were enrolled in the study...
March 2024: Tüberküloz Ve Toraks
#38
JOURNAL ARTICLE
Cristina Cacheiro-Llaguno, Ralph Mösges, David Calzada, Sandra González-de la Fuente, Eliana Quintero, Jerónimo Carnés
BACKGROUND: Studying the sensitisation profiles of patients with allergies allows for a deeper understanding of the disease which may facilitate the selection of the best-personalised allergen immunotherapy. This observational, cross-sectional, multicentre study aimed to demonstrate the heterogeneity of the German population with allergies by analysing specific immunoglobulin E (sIgE) patterns towards aeroallergens and exploring the relationship between sensitisation and clinical symptoms...
April 27, 2024: Clinical and Experimental Allergy
#39
JOURNAL ARTICLE
Laura Alves Ribeiro Oliveira, Alessandro Sousa Correa, Thiago Alves de Jesus, Miguel Junior Sordi Bortolini, Ernesto Akio Taketomi, Rafael de Oliveira Resende
The emergence of COVID-19 caused by SARS-CoV-2 prompted an unprecedented global response to develop vaccines at an accelerated pace. Messenger RNA (mRNA) and adenovirus vector vaccines emerged as the frontrunners in global immunization efforts, significantly reducing hospitalization, severity, and mortality, supplemented by inactivated virus-based vaccines in developing countries. However, concerns regarding adverse effects, including allergic reactions, have been raised. This study aimed to investigate the adverse effects following COVID-19 vaccination, particularly in atopic and non-atopic individuals...
April 12, 2024: Vaccines
#40
JOURNAL ARTICLE
Tipanan Pisithkul, Tippapha Pisithkul, Mongkol Lao-Araya
BACKGROUND: Global awareness of ambient air pollution has heightened due to its detrimental impact on health, particularly in regions with elevated PM2.5 levels. Chiang Mai has emerged as an area experiencing the highest PM2.5 levels in Thailand. OBJECTIVES: to examine the prevalence of respiratory allergies and assess the impact of air pollution on the health-related quality of life (QoL) among university students in Chiang Mai. METHODS: Chiang Mai University (CMU) and Maejo University (MJU) students were recruited...
April 8, 2024: International Journal of Environmental Research and Public Health
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