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Rhinitis and asthma

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https://www.readbyqxmd.com/read/29168570/specific-immunotherapy-in-lar-a-randomized-double-blind-placebo-controlled-trial-with-phleum-pratense-subcutaneous-allergen-immunotherapy
#1
Carmen Rondón, Natalia Blanca-López, Paloma Campo, Cristobalina Mayorga, Raquel Jurado-Escobar, Maria J Torres, Gabriela Canto, Miguel Blanca
BACKGROUND: Allergen immunotherapy has been shown to be an effective treatment for local allergic rhinitis (LAR) to house dust mites. Studies with pollen allergen immunotherapy are limited to observational studies. The aim of this study was to evaluate the clinical efficacy and safety of Phleum pratense subcutaneous immunotherapy (Phl-SCIT) in LAR. METHODS: In a randomized double-blind placebo-controlled study, 56 patients with moderate-severe LAR to grass pollen received Phl-SCIT with a depigmented-polymerized pollen vaccine or placebo for the first year, and Phl-SCIT the second one...
November 23, 2017: Allergy
https://www.readbyqxmd.com/read/29167579/the-first-1000-days-of-life-factors-associated-with-childhood-asthma-symptoms-brisa-cohort-brazil
#2
Joelma Ximenes Prado Teixeira Nascimento, Cecilia Claudia Costa Ribeiro, Rosângela Fernandes Lucena Batista, Maria Teresa Seabra Soares de Britto Alves, Vanda Maria Ferreira Simões, Luana Lopes Padilha, Viviane Cunha Cardoso, Elcio Oliveira Vianna, Heloisa Bettiol, Marco Antonio Barbieri, Antônio Augusto Moura Da Silva
This prospective study used data from the BRISA Cohort, São Luís, Brazil (n = 1140) and analyzed associations between environmental factors up to the first 1000 days of life and "Childhood Asthma Symptoms". "Childhood Asthma Symptoms" was a latent variable based on the number of wheezing episodes, emergency care visit due to wheezing, diagnosis of asthma and diagnosis of rhinitis. A theoretical model that included prenatal factors (socioeconomic status, pregestational body mass index-BMI, soft drink and junk food consumption), birth factors (gestational age, smoking and diseases during pregnancy, birth weight and type of delivery), first year of life factors (breastfeeding, environmental aeroallergens and respiratory diseases) and BMI z-score in the second year of life, was analyzed by structural equation modeling...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29162060/long-term-prognosis-of-chronic-cough-a-prospective-observational-cohort-study
#3
Heikki O Koskela, Anne M Lätti, Minna K Purokivi
BACKGROUND: The long-term prognosis of chronic cough and its determinants need to be clarified. METHODS: This is a prospective, observational cohort study. Eighty-nine unselected subjects with chronic (> 8 weeks' duration) cough were carefully investigated: Clinical examination, symptom questionnaire, Leicester Cough Questionnaire (LCQ), skin prick tests, ambulatory peak expiratory flow monitoring, spirometry before and after 0.4 mgs of salbutamol, exhaled nitric oxide concentration measurement, hypertonic saline cough provocation test, and histamine bronchial provocation test...
November 21, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29161054/great-flood-and-aeroallergen-sensitization-in-children-with-asthma-and-or-allergic-rhinitis
#4
Nualanong Visitsunthorn, Wanwipa Chaimongkol, Kittipos Visitsunthorn, Punchama Pacharn, Orathai Jirapongsananuruk
BACKGROUND: Flooding may affect aeroallergen sensitization. OBJECTIVE: To evaluate aeroallergen sensitization in children with asthma and/or allergic rhinitis (AR) by skin prick test (SPT) before and after the great flood of 2011 in Bangkok, Thailand. METHODS: The study was performed retrospectively in asthma and/or AR children (aged 0-18 years) in Siriraj Hospital, Bangkok, Thailand from 2009 to 2013. All of the cases received SPT with common aeroallergens...
November 22, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/29160383/epidemiological-trends-of-allergic-diseases-in-adolescents
#5
Silvia de Souza Campos Fernandes, Cláudia Ribeiro de Andrade, Cristina Gonçalves Alvim, Paulo Augusto Moreira Camargos, Cássio da Cunha Ibiapina
OBJECTIVE: To assess the prevalences of asthma, allergic rhinitis, and allergic rhinoconjunctivitis in adolescents in the city of Belo Horizonte, Brazil, in 2012 by administering the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire, as well as to compare the observed prevalences with those found in studies performed 10 years earlier and employing the same methodology used here. METHODS: This was a cross-sectional study conducted between May and December of 2012 and involving adolescents in the 13- to 14-year age bracket...
September 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29159975/rcat-reflects-symptom-control-and-quality-of-life-in-allergic-rhinoconjunctivitis-patients
#6
J-P Liedtke, A Mandl, J Köther, J Chwieralski, K Shah-Hosseini, U Pieper-Fürst, S Allekotte, R Mösges
BACKGROUND: The Global Allergy and Asthma European Network (GA(2) LEN) Taskforce has requested more data on correlations between various Patient Reported Outcomes (PROs) in clinical trials on allergy. We compared three tools-the Rhinitis Control Assessment Test (RCAT), Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ), and Rhinitis Total Symptom Score (RTSS)-to determine whether the RCAT alone is a sufficient primary outcome parameter in clinical trials on allergic rhinoconjunctivitis...
November 21, 2017: Allergy
https://www.readbyqxmd.com/read/29157860/advances-in-rhinitis-models-and-mechanisms
#7
REVIEW
Anne K Ellis, Mark W Tenn
OBJECTIVE: To summarize studies highlighting recent advances in rhinitis-related research in the past 2 years. DATA SOURCES: Original research articles were procured and examined from the Rhinitis and Upper Airway Disease section of the 2015 to 2017 Annals of Allergy, Asthma & Immunology issues. Additional original research articles were identified from PubMed and Google Scholar using the following search terms: allergic rhinitis, rhinitis, chronic rhinosinusitis, environmental exposure unit, and nasal allergen challenge...
November 18, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29157164/concentrations-and-number-size-distribution-of-fine-and-nanoparticles-in-a-traditional-finnish-bakery
#8
Antti Karjalainen, Maija Leppänen, Jani Leskinen, Tiina Torvela, Pertti Pasanen, Jarkko Tissari, Mirella Miettinen
In bakeries, high concentrations of flour dust can exist and ovens release particles into the air as well. Particle concentrations (mass, number) and number size distribution may vary considerably but the variation is not commonly studied. Furthermore, the role of the smallest size fractions is rarely considered in the exposure assessment due to their small mass. The objectives of this work were to find out how concentrations and number size distribution of fine and nanoparticles vary in a traditional Finnish bakery, and to determine the exposure of a dough maker to the nanoparticle fraction of the inhalable dust...
November 20, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/29153857/predicting-the-atopic-march-results-from-the-canadian-healthy-infant-longitudinal-development-study
#9
Maxwell M Tran, Diana L Lefebvre, Christoffer Dharma, David Dai, Wendy Y W Lou, Padmaja Subbarao, Allan B Becker, Piush J Mandhane, Stuart E Turvey, Malcolm R Sears
BACKGROUND: The atopic march describes the progression from atopic dermatitis during infancy to asthma and allergic rhinitis in later childhood. In a Canadian birth cohort we investigated whether concomitant allergic sensitization enhances subsequent development of these allergic diseases at age 3 years. METHODS: Children completed skin prick testing at age 1 year. Children were considered sensitized if they produced a wheal 2 mm or larger than that elicited by the negative control to any of 10 inhalant or food allergens...
November 1, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29153708/pathophysiology-of-il-33-and-il-17-in-allergic-disorders
#10
REVIEW
Rinkesh Kumar Gupta, Kriti Gupta, Premendra D Dwivedi
Allergic diseases are among common clinical conditions, affecting millions of children and adults throughout the world. Food allergies, skin allergies (atopic dermatitis), and respiratory allergies (allergic rhinitis and asthma) are the common types of allergies. Recently discovered cytokines IL-17 and IL-33 have been found to play an important role in the pathogenicity of various hypersensitive disorders. After exposure to allergens or infection with parasites or viruses, IL-17 and IL-33 producing cells, such as Th17 and specialized epithelial cells respectively, become activated and trigger the pathogenic immune responses in different susceptible conditions...
November 11, 2017: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/29150715/interleukin-33-promotes-helper-t-cell-type-2-17-inflammation-in-children-with-allergic-rhinitis
#11
Yuanming Wang, Chuling Li, Xianglin Luo, Deyu Xu, Yaxiong Xu, Guanquan Li, Fang Liao, Shujuan Tan
OBJECTIVES: Interleukin-33 is a recently described cytokine which involved in helper T cell type-2 (Th2) mediated diseases. However, its regulatory effect in the pathogenesis of children allergic rhinitis (AR) needs to be further characterized. This study aims to evaluate the expression and role of IL-33 in children with AR. METHODS: Forty children with AR and twenty normal controls were included. IL-33 and Th cytokine production in serum and nasal lavage was examined by immunosorbent assay (ELISA), respectively...
November 17, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29150353/barrier-dysfunction-in-the-nasal-allergy
#12
REVIEW
Ayumi Fukuoka, Tomohiro Yoshimoto
Epithelial cells form the first physiological barrier against invasion by pathogens and the infiltration of allergens. Tight junctions (TJ), a cell-cell junctional complex located on the apical side of epithelial cells, have a critical role in the maintenance of epithelial barrier function. Impaired TJ structures are observed in patients with asthma, atopic dermatitis and nasal allergy; therefore, the dysfunction of epithelial barriers might be involved in the initiation or progression of allergic diseases...
November 14, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29146015/tablet-based-sublingual-immunotherapy-for-respiratory-allergy
#13
REVIEW
L Prieto
Allergic respiratory disease represents a significant and expanding health problem worldwide. The gold standard of therapeutic intervention is still grucocorticosteroids, although they are not effective in all patients and may cause side effects. Allergen Immunotherapy has been administrated as subcutaneous injections for treatment of allergic rhinoconjunctivitis and asthma and has been practiced for the past century. Sublingual immunotherapy (SLIT) tablets are now available for grass- or ragweed-induced rhinoconjunctivitis and will be available in Spain for house dust mite (HDM)-induced rhinoconjunctivitis and asthma in the next months...
November 13, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29143385/patterns-of-allergic-sensitization-and-atopic-dermatitis-from-1-to-3-years-effects-on-allergic-diseases
#14
C Dharma, D L Lefebvre, M M Tran, W Y W Lou, P Subbarao, A B Becker, P J Mandhane, S E Turvey, M R Sears
BACKGROUND: While allergic sensitization and atopic dermatitis (AD) are known to increase the risk for allergic diseases, the impact of different temporal and clinical patterns of sensitization and AD is less well defined. OBJECTIVE: We investigated patterns of sensitization and AD from early infancy to age 3, and the differential risk for developing allergic diseases within each pattern in a general cohort. METHODS: Children (n=2629) from the Canadian Healthy Infant Longitudinal Development (CHILD) Study underwent skin prick tests and were assessed clinically for AD at ages 1 and 3 years...
November 16, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29142570/assessment-of-work-related-asthma-cases-our-three-year-experience
#15
Ayse Coskun Beyan, Nur Safak Alici, Arif Cimrin
Objective: Work-related asthma (WRA) is one of the most common occupational diseases. In this study, we aimed to review diagnosing procedures and the characteristics of patients who were diagnosed with WRA. Methods: Between November 2013 and June 2016; 214 patients were referred to our clinic with WRA suspicion by an occupational health specialist, personal visit, chest disease specialists [61 (28%), 51 (23%), and 102 (47%) respectively]. Occupational history, functional and radiological assessment, skin prick test, PEF monitoring were done...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29141605/an-intronic-single-nucleotide-polymorphism-rs13217795-in-foxo3-is-associated-with-asthma-and-allergic-rhinitis-a-case-case-control-study
#16
Justin Z Amarin, Randa G Naffa, Haya H Suradi, Yousof M Alsaket, Nathir M Obeidat, Tareq M Mahafza, Malek A Zihlif
BACKGROUND: Asthma and allergic rhinitis are respiratory diseases with a significant global burden. Forkhead box O3 (FOXO3) is a gene involved in the etiology of a number of respiratory diseases. The objective of this study is to assess the association of rs13217795, an intronic FOXO3 single-nucleotide polymorphism, with asthma and allergic rhinitis. METHODS: In this case-case-control genetic association study, genotyping was conducted using the PCR-RFLP method...
November 15, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/29135514/prevalence-and-clinical-characteristics-of-local-allergic-rhinitis-to-house-dust-mites
#17
Yoo Seob Shin, Chang-Gyu Jung, Hae-Sim Park
PURPOSE OF REVIEW: Local allergic rhinitis (LAR) is a recently classified subtype of rhinitis defined by a nasal allergic response in patients without systemic evidence of atopy. Recent studies have reported the prevalence, clinical course, culprit allergens, diagnostic methods and treatment outcomes of LAR. The purpose of this review is to summarize the most relevant and updated scientific evidence for LAR, especially focusing on its prevalence and clinical characteristics. RECENT FINDINGS: LAR is found in a significant proportion (3...
November 14, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29133326/risks-for-comorbidity-in-children-with-atopic-disorders-an-observational-study-in-dutch-general-practices
#18
David H J Pols, Arthur M Bohnen, Mark M J Nielen, Joke C Korevaar, Patrick J E Bindels
OBJECTIVE: This study aimed to investigate both atopic and non-atopic comorbid symptoms and diseases in children with physician-diagnosed atopic disorders (atopic eczema, asthma and allergic rhinitis). METHODS: All children aged 0-18 years listed in a nationwide primary care database (the Netherlands Institute for Health Services Research-Primary Care Database) with routinely collected healthcare data in 2014 were selected. Children with atopic disorders were matched on age and gender with non-atopic controls within the same general practice...
November 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29133218/cluster-analysis-identifies-3-phenotypes-within-allergic-asthma
#19
María Paz Sendín-Hernández, Carmelo Ávila-Zarza, Catalina Sanz, Asunción García-Sánchez, Elena Marcos-Vadillo, Francisco J Muñoz-Bellido, Elena Laffond, Christian Domingo, María Isidoro-García, Ignacio Dávila
BACKGROUND: Asthma is a heterogeneous chronic disease with different clinical expressions and responses to treatment. In recent years, several unbiased approaches based on clinical, physiological, and molecular features have described several phenotypes of asthma. Some phenotypes are allergic, but little is known about whether these phenotypes can be further subdivided. OBJECTIVE: We aimed to phenotype patients with allergic asthma using an unbiased approach based on multivariate classification techniques (unsupervised hierarchical cluster analysis)...
November 10, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29132467/-distribution-characteristics-of-serum-specific-ige-for-inhaled-allergens-in-children-with-different-airway-allergic-diseases
#20
Kang Zhu, Xiao-Ling Hou, Hui-Jie Huang, Ya-Ru Wang, Yi-Xin Ren, Xin Ni, Li Xiang
OBJECTIVE: To investigate the distribution characteristics of serum specific IgE (sIgE) for inhaled allergens in children with different airway allergic diseases. METHODS: Fluorescent enzyme-linked immunosorbent assay on the UniCAP250 system was performed to measure serum sIgE for 9 common inhaled allergens in 256 children aged 3-14 years with different airway allergic diseases. According to the clinical diagnosis, these children were divided into rhinitis group (37 children with allergic rhinitis), asthma group (82 children with bronchial asthma), and rhinitis-asthma group (137 children with allergic rhinitis complicated by bronchial asthma)...
November 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
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