Naiara Cristina Bessas, Evelyn Christine de Souza Arantes, Natasha Marques Cassani, Uriel Enrique Aquino Ruiz, Igor Andrade Santos, Daniel Oliveira Silva Martins, Ana Laura Costa Oliveira, Giovanna André Antoniucci, Arthur Henrique Cavalcante de Oliveira, Gilson DeFreitas-Silva, Ana Carolina Gomes Jardim, Renata Galvão de Lima
Nitric oxide (NO) acts in different physiological processes, such as blood pressure control, antiparasitic activities, neurotransmission, and antitumor action. Among the exogenous NO donors, ruthenium nitrosyl/nitro complexes are potential candidates for prodrugs, due to their physicochemical properties, such as thermal and physiological pH stability. In this work, we proposed the synthesis and physical characterization of the new nitro terpyridine ruthenium (II) complexes of the type [RuII (L)(NO2 )(tpy)]PF6 where tpy = 2,2':6',2"-terpyridine; L = 3,4-diaminobenzoic acid (bdq) or o-phenylenediamine (bd) and evaluation of influence of diimine bidentate ligand NH...
April 11, 2024: Nitric Oxide: Biology and Chemistry