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https://www.readbyqxmd.com/read/29471048/new-innovative-method-relating-guided-surgery-to-dental-implant-placement
#1
Marie-Alix Fauroux, Marie De Boutray, Eve Malthiéry, Jacques-Henri Torres
INTRODUCTION: Companies selling dental implant guided systems mostly offer similar surgical guides. The purpose of this paper is to present an innovative guided surgery system which originality lies in its guidance device, and to report the author's experience in using this system for dental implant surgery. TECHNICAL PROTOCOL: Two parallel tubes on either side of the drilling axis guide the successive drills and the implant placement. As a result of the lateral guidance, there is no friction of the drills on the surgical guide which would damage it or contaminate the drilling hole with particles torn out from the guide...
February 19, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29470774/multi-indication-and-combination-pricing-and-reimbursement-of-pharmaceuticals-opportunities-for-improved-health-care-through-faster-uptake-of-new-innovations
#2
Ulf Persson, J M Norlin
Many pharmaceuticals are effective in multiple indications and the degree of effectiveness may differ. A product-based pricing and reimbursement system with a single price per product is insufficient to reflect the variable values between different indications. The objective of this article is to present examples of actual pricing and reimbursement decisions using current value-based pricing in Sweden and to discuss their implications and possible solutions. The value of several cancer drugs was estimated for various indications based on a willingness-to-pay threshold of 1 million SEK (EUR 104,000) per QALY gained...
February 22, 2018: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/29470707/modeling-simulation-and-employing-dilution-dialysis-microfluidic-chip-ddmc-for-heightening-proteins-refolding-efficiency
#3
F Kashanian, M M Masoudi, A Shamloo, M Habibi-Rezaei, A A Moosavi-Movahedi
Miniaturized systems based on the principles of microfluidics are widely used in various fields, such as biochemical and biomedical applications. Systematic design processes are demanded the proper use of these microfluidic devices based on mathematical simulations. Aggregated proteins (e.g., inclusion bodies) in solution with chaotropic agents (such as urea) at high concentration in combination with reducing agents are denatured. Refolding methods to achieve the native proteins from inclusion bodies of recombinant protein relying on denaturant dilution or dialysis approaches for suppressing protein aggregation is very important in the industrial field...
February 22, 2018: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/29470435/creative-arts-interventions-for-stress-management-and-prevention-a-systematic-review
#4
REVIEW
Lily Martin, Renate Oepen, Katharina Bauer, Alina Nottensteiner, Katja Mergheim, Harald Gruber, Sabine C Koch
Stress is one of the world's largest health problems, leading to exhaustion, burnout, anxiety, a weak immune system, or even organ damage. In Germany, stress-induced work absenteeism costs about 20 billion Euros per year. Therefore, it is not surprising that the Central Federal Association of the public Health Insurance Funds in Germany ascribes particular importance to stress prevention and stress management as well as health enhancing measures. Building on current integrative and embodied stress theories, Creative Arts Therapies (CATs) or arts interventions are an innovative way to prevent stress and improve stress management...
February 22, 2018: Behavioral Sciences
https://www.readbyqxmd.com/read/29469632/hybrid-reconstruction-of-the-aortic-arch-using-a-double-branched-stent-graft-in-a-canine-model
#5
Fan Qiao, Cunhua Su, Qingqi Han, Mengwei Tan, Jun Wang, Yang Liu, Fanglin Lu, Lin Han, Zhiyun Xu
PURPOSE: To report the results of a hybrid approach to aortic arch repair using an innovative unibody double-branched stent graft in a canine model. MATERIALS AND METHODS: The stent-graft system consists of two parts: the main body and two branches for reconstruction of the supra-arch branches. There is a 2-cm-long suturing portion at the proximal end of the main body. Twenty adult German sheep dogs underwent a hybrid surgical treatment to place the stent-grafts into the proximal descending aorta and the supra-arch branches...
February 22, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29468636/oxidation-catalysis-by-iron-and-manganese-porphyrins-within-enzyme-like-cages
#6
REVIEW
Marco Chino, Linda Leone, Gerardo Zambrano, Fabio Pirro, Daniele D'Alonzo, Vincenzo Firpo, Diaa Aref, Liliana Lista, Ornella Maglio, Flavia Nastri, Angela Lombardi
Inspired by natural heme-proteins, scientists have attempted for decades to design efficient and selective metalloporphyrin-based oxidation catalysts. Starting from the pioneering work on small molecule mimics in the late 1970s, we have assisted to a tremendous progress in designing cages of different nature and complexity, able to accommodate metalloporphyrins. With the intent of tuning and controlling their reactivity, more and more sophisticated and diverse environments are continuously exploited. In this review, we will survey the current state of art in oxidation catalysis using iron- and manganese-porphyrins housed within designed or engineered protein cages...
February 22, 2018: Biopolymers
https://www.readbyqxmd.com/read/29468626/deployment-of-field-hospitals-to-disaster-regions-insights-from-ten-medical-relief-operations-spanning-three-decades
#7
Michael Naor, Samuel N Heyman, Tarif Bader, Ofer Merin
OBJECTIVE: The Israeli Defense Force (IDF) Medical Corps developed a model of airborne field hospital. This model was structured to deal with disaster settings, requiring self-sufficiency, innovation and flexible operative mode in the setup of large margins of uncertainty regarding the disaster environment. The current study is aimed to critically analyze the experience, gathered in ten such missions worldwide. METHODS: Interviews with physicians who actively participated in the missions from 1988 until 2015 as chief medical officers combined with literature review of principal medical and auxiliary publications in order to assess and integrate information about the assembly of these missions...
October 2017: American Journal of Disaster Medicine
https://www.readbyqxmd.com/read/29468412/fuzzy-expert-system-based-on-a-novel-hybrid-stem-cell-hsc-algorithm-for-classification-of-micro-array-data
#8
S Arul Antran Vijay, P GaneshKumar
In the growing scenario, microarray data is extensively used since it provides a more comprehensive understanding of genetic variants among diseases. As the gene expression samples have high dimensionality it becomes tedious to analyze the samples manually. Hence an automated system is needed to analyze these samples. The fuzzy expert system offers a clear classification when compared to the machine learning and statistical methodologies. In fuzzy classification, knowledge acquisition would be a major concern...
February 21, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/29468141/impact-of-the-gut-microbiota-on-intestinal-immunity-mediated-by-tryptophan-metabolism
#9
REVIEW
Jing Gao, Kang Xu, Hongnan Liu, Gang Liu, Miaomiao Bai, Can Peng, Tiejun Li, Yulong Yin
The gut microbiota influences the health of the host, especially with regard to gut immune homeostasis and the intestinal immune response. In addition to serving as a nutrient enhancer, L-tryptophan (Trp) plays crucial roles in the balance between intestinal immune tolerance and gut microbiota maintenance. Recent discoveries have underscored that changes in the microbiota modulate the host immune system by modulating Trp metabolism. Moreover, Trp, endogenous Trp metabolites (kynurenines, serotonin, and melatonin), and bacterial Trp metabolites (indole, indolic acid, skatole, and tryptamine) have profound effects on gut microbial composition, microbial metabolism, the host's immune system, the host-microbiome interface, and host immune system-intestinal microbiota interactions...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29467421/application-of-kernel-principal-component-analysis-and-computational-machine-learning-to-exploration-of-metabolites-strongly-associated-with-diet
#10
Yuka Shiokawa, Yasuhiro Date, Jun Kikuchi
Computer-based technological innovation provides advancements in sophisticated and diverse analytical instruments, enabling massive amounts of data collection with relative ease. This is accompanied by a fast-growing demand for technological progress in data mining methods for analysis of big data derived from chemical and biological systems. From this perspective, use of a general "linear" multivariate analysis alone limits interpretations due to "non-linear" variations in metabolic data from living organisms...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29466982/early-life-exposure-to-pm-2-5-and-risk-of-acute-asthma-clinical-encounters-among-children-in-massachusetts-a-case-crossover-analysis
#11
Roxana Khalili, Scott M Bartell, Xuefei Hu, Yang Liu, Howard H Chang, Candice Belanoff, Matthew J Strickland, Verónica M Vieira
BACKGROUND: Associations between ambient particulate matter < 2.5 μm (PM2.5 ) and asthma morbidity have been suggested in previous epidemiologic studies but results are inconsistent for areas with lower PM2.5 levels. We estimated the associations between early-life short-term PM2.5 exposure and the risk of asthma or wheeze clinical encounters among Massachusetts children in the innovative Pregnancy to Early Life Longitudinal (PELL) cohort data linkage system. METHODS: We used a semi-bidirectional case-crossover study design with short-term exposure lags for asthma exacerbation using data from the PELL system...
February 21, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29466613/readily-production-of-flow-reactor-cartridges-by-3d-printing-of-thermostable-enzymes
#12
Manfred Maier, Carsten P Radtke, Jürgen Hubbuch, Christof M Niemeyer, Kersten S Rabe
Compartmentalization of chemical reactions is an essential principle of life that provides a major source of innovation for the development of novel approaches in biocatalysis. To implement spatially controlled biotransformations, rapid manufacturing methods are needed for the production of biocatalysts applicable in flow systems. While three-dimensional (3D) printing techniques offer high throughput manufacturing capability, they are not usually compatible with the delicate nature of enzymes, which call for physiological processing parameters...
February 21, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29466056/a-guide-to-follow-on-biologics-and-biosimilars-with-a-focus-on-insulin
#13
Richard Dolinar, Frank Lavernia, Steven Edelman
OBJECTIVE: Many healthcare providers in the U.S. are not familiar with follow-on biologics and biosimilars nor with their critical distinctions from standard generics. Our aim is to provide a detailed review of both, with a focus on insulins in the U.S. regulatory system. METHODS: Literature has been reviewed to provide information on various aspects of biosimilars and a follow-on biologic of insulin. This will include structure, efficacy, cost, switching, and legal issues...
February 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29463334/the-role-of-oral-health-in-complex-emergencies-and-disaster-rehabilitation-medicine
#14
Vishal R Aggarwal
This paper presents an overview of the importance of oral health in complex emergencies. It highlights the importance of maintaining general and oral health in the acute, intermediate and long-term phases of such events which are increasing in frequency. The importance of oral health as an early warning sign for systemic disease and deprivation is also explored along with the crucial role of oral health in maintaining quality of life through adequate nutrition and speech. The overview of oral health in these situations identifies the need for training dental personnel as members of rehabilitation teams that set out to manage these disasters...
February 21, 2018: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29463312/sms-text-messaging-to-measure-working-time-the-design-of-a-time-use-study-among-general-practitioners
#15
Daniël van Hassel, Lud van der Velden, Dinny de Bakker, Ronald Batenburg
BACKGROUND: Measuring the working hours of general practitioners (GPs) is an important but complex task due to the effects of bias related to self-reporting, recall, and stress. In this paper we describe the deployment, feasibility, and implementation of an innovative method for measuring, in real time, GPs' working time, plus the response to the study. METHODS: A Short Message Service (SMS) application was developed which sent messages at random to GPs during their working week...
February 20, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29462326/secreted-frizzled-related-protein-2-sfrp2-expression-promotes-lesion-proliferation-via-canonical-wnt-signaling-and-indicates-lesion-borders-in-extraovarian-endometriosis
#16
T Heinosalo, M Gabriel, L Kallio, P Adhikari, K Huhtinen, T D Laajala, E Kaikkonen, A Mehmood, P Suvitie, H Kujari, T Aittokallio, A Perheentupa, M Poutanen
STUDY QUESTION: What is the role of SFRP2 in endometriosis? SUMMARY ANSWER: SFRP2 acts as a canonical WNT/CTNNB1 signaling agonist in endometriosis, regulating endometriosis lesion growth and indicating endometriosis lesion borders together with CTNNB1 (also known as beta catenin). WHAT IS KNOWN ALREADY: Endometriosis is a common, chronic disease that affects women of reproductive age, causing pain and infertility, and has significant economic impact on national health systems...
February 15, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29462078/the-impact-of-a-health-information-technology-focused-patient-centered-medical-neighborhood-program-among-medicare-beneficiaries-in-primary-care-practices-the-effect-on-patient-outcomes-and-spending
#17
Sean Orzol, Rosalind Keith, Mynti Hossain, Michael Barna, G Greg Peterson, Timothy Day, Boyd Gilman, Laura Blue, Keith Kranker, Kate A Stewart, Sheila Hoag, Lorenzo Moreno
BACKGROUND: The Center for Medicare & Medicaid Innovation (CMMI) tests new models of paying for or delivering health care services and expands models that improve health outcomes while lowering medical spending. CMMI gave TransforMED, a national learning and dissemination contractor, a 3-year Health Care Innovation Award (HCIA) to integrate health information technology systems into physician practices. This paper estimates impacts of TransforMED's HCIA-funded program on patient outcomes and Medicare parts A and B spending...
February 16, 2018: Medical Care
https://www.readbyqxmd.com/read/29461991/technology-s-role-in-quality-improvement-and-operational-efficiency
#18
Judy Blauwet, Mandy Bell
Technology for technology's sake is never a good idea. There must be a purpose behind it. It must help us do our jobs better. Technology allows healthcare to remain affordable and, as such, accessible. Technology must increase access to care, improve safety, make test results more reliable, and help teams communicate better for a seamless care experience.Avera Health, a health system based in Sioux Falls, South Dakota, comprises 330 facilities in 100 communities in five states. Sponsored by the Benedictine and Presentation Sisters, Avera is a healthcare ministry whose employees deliver high-quality care with compassion...
April 2018: Frontiers of Health Services Management
https://www.readbyqxmd.com/read/29461353/realigning-shared-governance-with-magnet%C3%A2-and-the-organization-s-operating-system-to-achieve-clinical-excellence
#19
Janette V Moreno, Anita S Girard, Wendy Foad
In 2012, an academic medical center successfully overhauled a 15-year-old shared governance to align 6 house-wide and 30 unit-based councils with the new Magnet Recognition Program® and the organization's operating system, using the processes of LEAN methodology. The redesign improved cross-council communication structures, facilitated effective shared decision-making processes, increased staff engagement, and improved clinical outcomes. The innovative structural and process elements of the new model are replicable in other health institutions...
March 2018: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29460642/novel-targeted-therapy-strategies-for-biliary-tract-cancers-and-hepatocellular-carcinoma
#20
Thomas T DeLeon, Daniel H Ahn, James M Bogenberger, Panos Z Anastasiadis, Mansi Arora, Ramesh K Ramanathan, Bashar A Aqel, George Vasmatzis, Mark J Truty, Rahmi Oklu, Tanios S Bekaii-Saab, Mitesh J Borad
Worldwide hepatobiliary cancers are the second leading cause of cancer related death. Despite their relevance, hepatobiliary cancers have a paucity of approved systemic therapy options. However, there are a number of emerging therapeutic biomarkers and therapeutic concepts that show promise. In hepatocellular carcinoma, nivolumab appears particularly promising and recently received US FDA approval. In intrahepatic cholangiocarcinoma, therapies targeting FGFR2 and IDH1 and immune checkpoint inhibitors are the furthest along and generating the most excitement...
February 20, 2018: Future Oncology
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