keyword
MENU ▼
Read by QxMD icon Read
search

System innovation

keyword
https://www.readbyqxmd.com/read/29244990/clinical-and-epidemiological-profile-of-breast-cancer-in-mexico-results-of-the-seguro-popular
#1
Nancy Reynoso-Noverón, Cynthia Villarreal-Garza, Enrique Soto-Perez-de-Celis, Claudia Arce-Salinas, Juan Matus-Santos, María Teresa Ramírez-Ugalde, Alberto Alvarado-Miranda, Paula Cabrera-Galeana, Abelardo Meneses-García, Fernando Lara-Medina, Enrique Bargalló-Rocha, Alejandro Mohar
Purpose One half of the Mexican population lacks comprehensive health care coverage. In 2003, a reform to the General Health Law was approved that led to the creation of the System of Social Protection in Health and made universal health coverage mandatory. The main innovation of this reform was Seguro Popular, which provided coverage for breast cancer. Here we report the outcomes of women with breast cancer treated at a cancer center in Mexico under Seguro Popular. Materials and Methods This was a retrospective cohort study that included all patients with breast cancer treated in the Instituto Nacional de Cancerología in Mexico City between January 2007 and December 2013 with Seguro Popular coverage...
December 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29244972/evaluating-an-ipad-app-in-measuring-wound-dimension-a-pilot-study
#2
P C B Khong, M S W Yeo, C C Goh
OBJECTIVE: This pilot study tested the reliability, validity and sensitivity of an innovative prototype iPad app, WoundAide, developed to measure wound dimension (length, width and surface area) using image analysis. METHOD: A prospective evaluation was conducted comparing WoundAide (WA) with two gold standard instruments, Wound Zoom (WZ) and Visitrak (VT). The study was conducted in a tertiary hospital in Singapore. Patients were recruited after obtaining local ethics approval...
December 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29244862/application-of-system-dynamics-and-participatory-spatial-group-model-building-in-animal-health-a-case-study-of-east-coast-fever-interventions-in-lundazi-and-monze-districts-of-zambia
#3
Chisoni Mumba, Eystein Skjerve, Magda Rich, Karl M Rich
East Coast Fever (ECF) is the most economically important production disease among traditional beef cattle farmers in Zambia. Despite the disease control efforts by the government, donors, and farmers, ECF cases are increasing. Why does ECF oscillate over time? Can alternative approaches such as systems thinking contribute solutions to the complex ECF problem, avoid unintended consequences, and achieve sustainable results? To answer these research questions and inform the design and implementation of ECF interventions, we qualitatively investigated the influence of dynamic socio-economic, cultural, and ecological factors...
2017: PloS One
https://www.readbyqxmd.com/read/29244195/decellularized-colorectal-cancer-matrix-as-bioactive-microenvironment-for-in-vitro-3d-cancer-research
#4
Martina Piccoli, Edoardo D'Angelo, Sara Crotti, Francesca Sensi, Luca Urbani, Edoardo Maghin, Alan Burns, Paolo De Coppi, Matteo Fassan, Massimo Rugge, Flavio Rizzolio, Antonio Giordano, Pierluigi Pilati, Enzo Mammano, Salvatore Pucciarelli, Marco Agostini
Three-dimensional (3D) cancer models are overlooking the scientific landscape with the primary goal of bridging the gaps between two-dimensional (2D) cell lines, animal models and clinical research. Here we describe an innovative tissue engineering approach applied to colorectal cancer (CRC) starting from decellularized human biopsies in order to generate an organotypic 3D-bioactive model. This in vitro 3D system recapitulates the ultrastructural environment of native tissue as demonstrated by histology, immunohistochemistry, immunofluorescence and scanning electron microscopy analyses...
December 15, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29243908/thin-film-nanocomposite-membrane-with-the-minimum-amount-of-mof-by-the-langmuir-schaefer-technique-for-nanofiltration
#5
Marta Navarro, Javier Benito, Lorena Paseta, Ignacio Gascón, Joaquin Coronas, Carlos Téllez
An innovative procedure for positioning a monolayer of hydrophilic metal-organic framework (MOF) MIL-101(Cr) nanoparticles (NPs) in thin film nanocomposite (TFN) membranes has been implemented by transferring a Langmuir-Schaefer (LS) film of the MOF in between the polyamide thin layer at the top and the cross-linked asymmetric polyimide (P84®) support at the bottom. The presence and layout of the LS-MIL-101(Cr) monolayer in the TFN membrane was confirmed by STEM-HAADF images, and XPS, EDS, EELS and AFM analysis...
December 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29243500/designing-medical-technology-for-resilience-integrating-health-economics-and-human-factors-approaches
#6
Simone Borsci, Ijeoma Uchegbu, Peter Buckle, Zhifang Ni, Simon Walne, George B Hanna
The slow adoption of innovation into healthcare calls into question the manner of evidence generation for medical technology. This paper identifies potential reasons for this including a lack of attention to human factors, poor evaluation of economic benefits, lack of understanding of the existing healthcare system and a failure to recognise the need to generate resilient products. Areas covered. Recognising a cross-disciplinary need to enhance evidence generation early in a technology's life cycle, the present paper proposes a new approach that integrates human factors and health economic evaluation as part of a wider systems approach to the design of technology...
December 15, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/29241437/the-swiss-mental-health-care-system
#7
Andres R Schneeberger, Bruce J Schwartz
The United States and Switzerland are among the world's wealthiest countries. Both are highly innovative and entrepreneurial, ranking high in global competitiveness and innovation and with similar liberal economies. This column highlights features of the health care system in Switzerland, a country with an exclusively private health insurance system, with federally mandated universal health insurance. Residents can choose from about 58 insurance companies. Switzerland regulates these companies and negotiates reimbursement rates...
December 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29241145/wet-chemical-etching-of-atom-probe-tips-for-artefact-free-analyses-of-nanoscaled-semiconductor-structures
#8
D Melkonyan, C Fleischmann, A Veloso, A Franquet, J Bogdanowicz, R J H Morris, W Vandervorst
We introduce an innovative specimen preparation method employing the selectivity of a wet-chemical etching step to improve data quality and success rates in the atom probe analysis of contemporary semiconductor devices. Firstly, on the example of an SiGe fin embedded in SiO2 we demonstrate how the selective removal of SiO2 from the final APT specimen significantly improves accuracy and reliability of the reconstructed data. With the oxide removal, we eliminate the origin of shape artefacts, i.e. the formation of a non-hemispherical tip shape, that are typically observed in the reconstructed volume of complex systems...
December 7, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/29240712/developing-an-agent-based-drug-model-to-investigate-the-synergistic-effects-of-drug-combinations
#9
Hongjie Gao, Zuojing Yin, Zhiwei Cao, Le Zhang
The growth and survival of cancer cells are greatly related to their surrounding microenvironment. To understand the regulation under the impact of anti-cancer drugs and their synergistic effects, we have developed a multiscale agent-based model that can investigate the synergistic effects of drug combinations with three innovations. First, it explores the synergistic effects of drug combinations in a huge dose combinational space at the cell line level. Second, it can simulate the interaction between cells and their microenvironment...
December 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29240429/stabilizing-nanocrystalline-oxide-nanofibers-at-elevated-temperatures-by-coating-nanoscale-surface-amorphous-films
#10
Lei Yao, Wei Pan, Jian Luo, Xiaohui Zhao, Jing Cheng, Hiroki Nishijima
Nanocrystalline materials often exhibit extraordinary mechanical and physical properties, but their applications at elevated temperatures are impaired by the rapid grain growth. Moreover, the grain growth in nanocrystalline oxide nanofibers at high temperatures can occur at hundreds of degrees lower than that would occur in corresponding bulk nanocrystalline materials, which would eventually break the fibers. Herein, by characterizing a model system of scandia-stabilized zirconia (ScSZ) using hot-stage in-situ scanning transmission electron microscopy (STEM), we discover that the enhanced grain growth in nanofibers is initiated at the surface...
December 14, 2017: Nano Letters
https://www.readbyqxmd.com/read/29240330/regulating-black-box-medicine
#11
W Nicholson Price
Data drive modern medicine. And our tools to analyze those data are growing ever more powerful. As health data are collected in greater and greater amounts, sophisticated algorithms based on those data can drive medical innovation, improve the process of care, and increase efficiency. Those algorithms, however, vary widely in quality. Some are accurate and powerful, while others may be riddled with errors or based on faulty science. When an opaque algorithm recommends an insulin dose to a diabetic patient, how do we know that dose is correct? Patients, providers, and insurers face substantial difficulties in identifying high-quality algorithms; they lack both expertise and proprietary information...
2017: Michigan Law Review
https://www.readbyqxmd.com/read/29240298/diabetic-macular-edema-innovative-technologies-and-economic-impact-new-opportunities-for-the-lombardy-region-healthcare-system
#12
Emanuela Foglia, Lucrezia Ferrario, Francesco Bandello, Camilla Ferri, Innocente Figini, Michela Franzin, Gianpiera Gambaro, Ugo Introini, Massimo Medaglia, Giovanni Staurenghi, Patrizia Tadini, Andrea Fomiatti, Davide Croce
PURPOSE: Diabetic macular edema (DME) is a leading cause of vision loss and blindness. The aim of this study was to evaluate the economic benefits of introducing additional alternative technologies (Dexamethasone intravitreal implant - DEX - and Aflibercept injections), compared with the historical scenario of Ranibizumab intravitreal injections. METHODS: A 3-year budget impact model was developed, taking into consideration the perspective of the Lombardy Region Healthcare Service (LRHS)...
December 14, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29240243/fabrication-and-evaluation-of-3d-printed-bcp-scaffolds-reinforced-with-zro2-for-bone-tissue-applications
#13
Min-Woo Sa, Bao-Ngoc B Nguyen, Rebecca A Moriarty, Timur Kamalitdinov, John P Fisher, Jong Young Kim
Fused deposition modeling (FDM) is a promising 3D printing and manufacturing step to create well interconnected porous scaffold designs from the computer-aided design (CAD) models for the next generation of bone scaffolds. The purpose of this study was to fabricate and evaluate a new biphasic calcium phosphate (BCP) scaffold reinforced with zirconia (ZrO2 ) by a FDM system for bone tissue engineering. The 3D slurry foams with blending agents were successfully fabricated by a FDM system. Blending materials were then removed after the sintering process at high temperature to obtain a targeted BCP/ZrO2 scaffold with the desired pore characteristics, porosity, and dimension...
December 14, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29239911/monitoring-student-immunization-screening-and-training-records-for-clinical-compliance-an-innovative-use-of-the-institutional-learning-management-system
#14
Julie Kientz Elting
Clinical compliance for nursing students is a complex process mandating them to meet facility employee occupational health requirements for immunization, screening, and training prior to patient contact. Nursing programs monitor clinical compliance with in-house management of student records, either paper or electronic, or by contracting with a vendor specializing in online record tracking. Regardless of method, the nursing program remains fully accountable for student preparation and bears the consequences of errors...
December 13, 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29239563/a-geographical-information-system-for-the-management-of-the-aquaculture-data-in-the-adriatic-sea-the-strengthening-of-centres-for-aquaculture-production-and-safety-surveillance-in-the-adriatic-countries-experience-present-capabilities-tools-and-functions
#15
Susanna Tora, Silvio Sacchini, Eddy Listeš, Tanja Bogdanović, Alessio Di Lorenzo, Muhamed Smajlović, Ahmed Smajlović, Jelena V Filipović, Vildana Tahirović, Danijela Šuković, Bojan Beljkas, Ardian Xinxo, Renis Maçi, Patrizia Colangeli, Federica Di Giacinto, Annamaria Conte
The European Commission (EC) regulation no. 854/2004 requires a systematic monitoring of chemical and microbiological contaminants in live bivalve molluscs, live echinoderms, live tunicates and live marine gastropods for human consumption through surveillance plans to be implemented in all European Union (EU) countries.A consortium of five Adriatic countries was set up in the framework of the Instrument of Pre-accession Assistance Adriatic Cross-border Cooperation Programme (IPA Adriatic CBC) 2007- 2013 with the aim of collecting data and distribute information on harvesting and production in mollusc areas...
November 8, 2017: Geospatial Health
https://www.readbyqxmd.com/read/29239189/-immunotherapy-in-the-treatment-of-lung-cancer
#16
O Fiala, O Šorejs, M Pešek, J Fínek
BACKGROUND: Lung cancer occupies the leading position of cancer incidence and mortality worldwide, including in the Czech Republic. Despite significant advances in systemic oncology treatments, lung cancer still has the worst prognosis, which is driving the need for innovative therapies and methods to treat this disease. Immunotherapy is a developing area of systemic oncology treatment, which has recently begun to be significantly applied to patients with lung carcinoma. The most useful type of immunotherapy currently employs checkpoint inhibitors, including CTLA-4 inhibitors (ipilimumab and tremelimumab) and PD-1/PD-L1 inhibitors (nivolumab, pembrolizumab, durvalumab, and avelumab)...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29238926/legal-regulations-of-restrictions-of-air-pollution-made-by-non-road-mobile-machinery-the-case-study-for-europe-a-review
#17
Konrad J Waluś, Łukasz Warguła, Piotr Krawiec, Jarosław M Adamiec
The high awareness of intensification and frequency of smog phenomenon all over the world in XXI age makes for detailed analyses of the reasons of its formation and prevention. The governments of the developed countries and conscious of real hazards, including many European countries, aim to restrict the emission of harmful gases. In literature, we can find the discussions on the influence of this phenomenon on the health and life of inhabitants of contaminated areas. Some elaborations of prognostic models, descriptions of pollution sources, the manner of their restriction, and the analysis of causal-consecutive correlation are also popular...
December 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29238332/application-of-flp-frt-system-to-construct-unmarked-deletion-in-helicobacter-pylori-and-functional-study-of-gene-hp0788-in-pathogenesis
#18
Xiaofei Ji, Ying Wang, Jiaojiao Li, Qianyu Rong, Xingxing Chen, Ying Zhang, Xiaoning Liu, Boqing Li, Huilin Zhao
Helicobacter pylori is a Gram-negative, microaerophilic bacterium associated with human gastric diseases. Further investigations on virulence genes are still required to clarify the pathogenic mechanism of H. pylori and the heterogeneous problem of infection. In order to develop an efficient and accurate method to study gene functions in H. pylori pathogenesis, an unmarked deletion method for both a single gene and a large fragment was established based on the FLP-FRT recombination system. Using this method, the gene hp0788, encoding an outer membrane protein (HofF), was deleted...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29238193/in-vivo-evaluation-of-a-novel-nanocomposite-porous-3d-scaffold-in-a-rabbit-model-histological-analysis
#19
Saffanah Khuder Mahmood, Intan-Shameha Abdul Razak, Mustafa Saddam Ghaji, Loqman Mohamed Yusof, Zaid Khudhur Mahmood, Mohd Adha Bin P Rameli, Zuki Abu Bakar Zakaria
The healing of load-bearing segmental defects in long bones is a challenge due to the complex nature of the weight that affects the bone part and due to bending, shearing, axial, and torsional forces. An innovative porous 3D scaffolds implant of CaCO3 aragonite nanocomposite derived from cockle shell was advanced for substitute bone solely for load-bearing cases. The biomechanical characteristics of such materials were designed to withstand cortical bone strength. In promoting bone growth to the implant material, an ideal surface permeability was formed by means of freeze drying and by adding copolymers to the materials...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29238188/effects-of-major-parameters-of-nanoparticles-on-their-physical-and-chemical-properties-and-recent-application-of-nanodrug-delivery-system-in-targeted-chemotherapy
#20
REVIEW
Jing Zhang, Hua Tang, Zefa Liu, Baoan Chen
Chemotherapy is still one of the main cancer therapy treatments, but the curative effect of chemotherapy is relatively low, as such the development of a new cancer treatment is highly desirable. The gradual maturation of nanotechnology provides an innovative perspective not only for cancer therapy but also for many other applications. There are a diverse variety of nanoparticles available, and choosing the appropriate carriers according to the demand is the key issue. The performance of nanoparticles is affected by many parameters, mainly size, shape, surface charge, and toxicity...
2017: International Journal of Nanomedicine
keyword
keyword
19761
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"