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https://www.readbyqxmd.com/read/29040516/integrated-mental-health-services-in-china-challenges-and-planning-for-the-future
#1
Di Liang, Vickie M Mays, Wei-Chin Hwang
Eager to build an integrated community-based mental health system, in 2004 China started the '686 Programme', whose purpose was to integrate hospital and community services for patients with serious mental illness. In 2015, the National Mental Health Working Plan (2015-2020) proposed an ambitious strategy for implementing this project. The goal of this review is to assess potential opportunities for and barriers to successful implementation of a community-based mental health system that integrates hospital and community mental health services into the general healthcare system...
October 13, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29040303/continuing-professional-development-for-medical-nursing-and-midwifery-cadres-in-malawi-tanzania-and-south-africa-a-qualitative-evaluation
#2
Caryl Feldacker, Jillian Pintye, Sheena Jacob, Michael H Chung, Lyn Middleton, Jill Iliffe, H Nina Kim
BACKGROUND: As innovations in the prevention and treatment of HIV and TB advance, continuing professional development (CPD) of health care workers (HCWs) remains a high priority, particularly in sub-Saharan Africa where dual TB/HIV epidemics are compounded by severe HCW shortages. There is further need to examine CPD programs to identify challenges and effective solutions to strengthen HIV/TB-related CPD. METHODS: Qualitative evaluations in Malawi, Tanzania and South Africa (RSA) were conducted using key informant interviews (KIIs) and focus group discussions (FGDs) in each country to identify barriers and enablers of effective HIV/TB-related CPD...
2017: PloS One
https://www.readbyqxmd.com/read/29040267/protecting-cows-in-small-holder-farms-in-east-africa-from-tsetse-flies-by-mimicking-the-odor-profile-of-a-non-host-bovid
#3
Rajinder K Saini, Benedict O Orindi, Norber Mbahin, John A Andoke, Peter N Muasa, David M Mbuvi, Caroline M Muya, John A Pickett, Christian W Borgemeister
BACKGROUND: For the first time, differential attraction of pathogen vectors to vertebrate animals is investigated for novel repellents which when applied to preferred host animals turn them into non-hosts thereby providing a new paradigm for innovative vector control. For effectively controlling tsetse flies (Glossina spp.), vectors of African trypanosomosis, causing nagana, repellents more powerful than plant derived, from a non-host animal the waterbuck, Kobus ellipsiprymnus defassa, have recently been identified...
October 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29036366/accounting-for-selectivity-bias-and-correlation-across-the-sequence-from-elevated-blood-pressure-to-hypertension-diagnosis-and-treatment
#4
Penny Gordon-Larsen, Samantha M Attard, Annie Green Howard, Barry M Popkin, Bing Zhang, Shufa Du, David K Guilkey
BACKGROUND: It is unknown whether efforts to reduce hypertension burden in countries with very high prevalence, would be more effective if directed at hypertension diagnosis vs. treatment. Most analyses do not address bias and correlation across the sequence from elevated blood pressure (BP) to hypertension diagnosis and treatment, leading to potentially misleading findings. METHODS: Using data spanning 18 years of the China Health and Nutrition Survey (n = 18,926; ages 18-75 years), we used an innovative 3-step, integrated system of equations to predict the sequence from: (i) elevated BP (systolic/diastolic BP ≥ 140/90 mm Hg) to (ii) diagnosed hypertension conditional on elevated BP, and to (iii) treatment (medication use) conditional on diagnosis, accounting for measured and unmeasured individual- and community-level confounders at each of the 3 steps...
September 26, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29035996/radioguided-occult-lesion-localization-technical-procedures-and-clinical-applications
#5
Gianpiero Manca, Sara Mazzarri, Domenico Rubello, Elisa Tardelli, Roberto C Delgado-Bolton, Francesco Giammarile, Manuela Roncella, Duccio Volterrani, Patrick M Colletti
PURPOSE: Regarding radioguided surgery, the concept of "radioguided occult lesion localization" (ROLL) is based on both preoperative interventional imaging and intraoperative radioguided detection of a clinically occult neoplastic lesion. METHODS: This methodology consists in the direct administration into the lesion of Tc-macroaggregated human albumin formed by relatively large particles retained at the injection site, which direct radioguided excisional biopsy...
October 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29035719/recent-advancements-in-the-mitigation-of-obnoxious-nitrogenous-gases
#6
REVIEW
Ishan Raj, A N Vaidya, R A Pandey, Amit Bansiwal, Sharvari Deshmukh, Hemant J Purohit
Nitrogenous gaseous emissions commonly have an obnoxious odor associated with it, which when discharged into the environment results in serious environmental problems and health hazards. Several strategies for mitigation of nitrogenous odorants have been reported which include physical, chemical and biological methods. Biological treatments are widely employed because of their efficiency even at low concentration, where physical and chemical methods are not effective. Most commonly used biological treatment methods are biofiltration, biotrickling filters and membrane bioreactors with innovative reactor design, mixing pattern, and air sparging, for example FEBR, ALR, etc...
October 13, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29035494/medical-devices-immunology-and-microbiology-devices-classification-of-the-automated-image-assessment-system-for-microbial-colonies-on-solid-culture-media-final-order
#7
(no author information available yet)
The Food and Drug Administration (FDA or we) is classifying the automated image assessment system for microbial colonies on solid culture media into class II (special controls). The special controls that apply to the device type are identified in this order and will be part of the codified language for the automated image assessment system for microbial colonies on solid culture media's classification. We are taking this action because we have determined that classifying the device into class II (special controls) will provide a reasonable assurance of safety and effectiveness of the device...
October 16, 2017: Federal Register
https://www.readbyqxmd.com/read/29035341/research-on-the-fusion-of-dependent-evidence-based-on-rank-correlation-coefficient
#8
Fengjian Shi, Xiaoyan Su, Hong Qian, Ning Yang, Wenhua Han
In order to meet the higher accuracy and system reliability requirements, the information fusion for multi-sensor systems is an increasing concern. Dempster-Shafer evidence theory (D-S theory) has been investigated for many applications in multi-sensor information fusion due to its flexibility in uncertainty modeling. However, classical evidence theory assumes that the evidence is independent of each other, which is often unrealistic. Ignoring the relationship between the evidence may lead to unreasonable fusion results, and even lead to wrong decisions...
October 16, 2017: Sensors
https://www.readbyqxmd.com/read/29034452/innovation-incentives-and-biomarkers
#9
Ariel D Stern, Brian M Alexander, Amitabh Chandra
Previously, we have discussed the importance of economic incentives in shaping markets for precision medicines. Here we consider incentives for biomarker development, including discovery and establishment. Biomarkers can reveal valuable information regarding diagnosis and prognosis, predict treatment efficacy or toxicity, serve as markers of disease progression, and serve as auxiliary endpoints for clinical trials. Some have multiple uses, while others have a specialized role, resulting in diverse incentives across players in the healthcare system...
October 16, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29032709/putative-predictors-of-efficacy-for-immune-checkpoint-inhibitors-in-non-small-cell-lung-cancer-facing-the-complexity-of-the-immune-system
#10
Giulia Grizzi, Mario Caccese, Anastasios Gkountakos, Luisa Carbognin, Giampaolo Tortora, Emilio Bria, Sara Pilotto
In non-small-cell lung cancer (NSCLC) the recent introduction of immunotherapy in daily clinical practice produced a wave of enthusiasm, however, this was rapidly moderated by the evidence that only some patients could experience a relevant clinical benefit. Therefore, a great effort from the scientific community has been dedicated to the identification and validation of reliable biomarkers able to drive the activity of immunotherapeutic agents. Areas covered. This analysis aims to review the main findings about predictive biomarkers for immunotherapy in lung cancer, retracing the history of PD-L1 and focusing on a series of innovative candidates, such as mutational load, immune cells populations and microbiome...
October 14, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29031933/relevant-models-and-elements-of-integrated-care-for-multi-morbidity-results-of-a-scoping-review
#11
Verena Struckmann, Fenna R M Leijten, Ewout van Ginneken, Markus Kraus, Miriam Reiss, Anne Spranger, Melinde R S Boland, Thomas Czypionka, Reinhard Busse, Maureen Rutten-van Mölken
BACKGROUND: In order to provide adequate care for the growing group of persons with multi-morbidity, innovative integrated care programmes are appearing. The aims of the current scoping review were to i) identify relevant models and elements of integrated care for multi-morbidity and ii) to subsequently identify which of these models and elements are applied in integrated care programmes for multi-morbidity. METHODS: A scoping review was conducted in the following scientific databases: Cochrane, Embase, PubMed, PsycInfo, Scopus, Sociological Abstracts, Social Services Abstracts, and Web of Science...
October 6, 2017: Health Policy
https://www.readbyqxmd.com/read/29031890/changing-perspectives-in-atopic-dermatitis
#12
REVIEW
E Serra-Baldrich, J O de Frutos, I Jáuregui, J C Armario-Hita, J F Silvestre, L Herraez, A Martín-Santiago, A Valero, J Sastre
Atopic dermatitis (AD) is a multifaceted disease that involves a complex interplay between the skin and the immune system. The course of the disease depends strongly on the genetic background of the patient and on yet poorly-defined environmental factors. Changes in lifestyle could be behind the dramatic rise in the prevalence of AD across continents; including hygienic conditions, food, social habits, skin microbiome or exposure to a number of allergens. Although AD typically develops in childhood and disappears after a few years, in a relatively large number of patients it continues into adulthood...
October 11, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29031507/-sport-coaching-for-psychological-and-social-recovery-after-hematological-cancer-an-innovative-perspective
#13
Sarah Calvin, Didier Blaise, Patrick Ben Soussan, Sarah Cuvelier, Nicolas Cicut, Laurence Caymaris, Yolande Arnault, Claude Onesta, Pierre Dantin, Patrice Viens
This study is a first step towards the transfer of knowledge and practices between psychological support and performance in elite sport and a patient's "social recovery" in oncology. This proposal brings together people engaged in a variety of healthcare and relationship support roles, and aims to set up a support system beyond the hospital context. It questions the ability of elite sport management and its main actors, the "Great Coaches", to contribute to the support of patients in cancer remission through an onco-coaching approach...
October 11, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29031292/a-new-integrated-tlc-mu-atr-sers-advanced-approach-for-the-identification-of-trace-amounts-of-dyes-in-mixtures
#14
Giorgia Sciutto, Silvia Prati, Irene Bonacini, Lucio Litti, Moreno Meneghetti, Rocco Mazzeo
The present research is focused on the setting up of an advanced analytical system for the detection of synthetic dyes. The system is based on the combination of an innovative thin layer chromatography (TLC) plate coupled with enhanced infrared (MU-ATR, metal underlayer attenuated total reflection) and Surface Enhanced Raman (SERS) spectroscopy. In particular, a TLC plate made of silver iodide (AgI) applied onto a gold coated glass slide (AgI@Au) is proposed as an efficient stationary phase for the separation of dyes mixtures...
October 23, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29030677/safe-surgery-for-all-early-lessons-from-implementing-a-national-government-driven-surgical-plan-in-ethiopia
#15
Daniel Burssa, Atlibachew Teshome, Katherine Iverson, Olivia Ahearn, Tigistu Ashengo, David Barash, Erin Barringer, Isabelle Citron, Kaya Garringer, Victoria McKitrick, John Meara, Abraham Mengistu, Swagoto Mukhopadhyay, Cheri Reynolds, Mark Shrime, Asha Varghese, Samson Esseye, Abebe Bekele
Recognizing the unmet need for surgical care in Ethiopia, the Federal Ministry of Health (FMOH) has pioneered innovative methodologies for surgical system development with Saving Lives through Safe Surgery (SaLTS). SaLTS is a national flagship initiative designed to improve access to safe, essential and emergency surgical and anaesthesia care across all levels of the healthcare system. Sustained commitment from the FMOH and their recruitment of implementing partners has led to notable accomplishments across the breadth of the surgical system, including but not limited to: (1) Leadership, management and governance-a nationally scaled surgical leadership and mentorship programme, (2) Infrastructure-operating room construction and oxygen delivery plan, (3) Supplies and logistics-a national essential surgical procedure and equipment list, (4) Human resource development-a Surgical Workforce Expansion Plan and Anaesthesia National Roadmap, (5) Advocacy and partnership-strong FMOH partnership with international organizations, including GE Foundation's SafeSurgery2020 initiative, (6) Innovation-facility-driven identification of problems and solutions, (7) Quality of surgical and anaesthesia care service delivery-a national peri-operative guideline and WHO Surgical Safety Checklist implementation, and (8) Monitoring and evaluation-a comprehensive plan for short-term and long-term assessment of surgical quality and capacity...
October 13, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29030628/synthetic-ecm-inspired-hybrid-platform-for-hollow-microcarriers-with-ros-triggered-nanoporation-hallmarks
#16
Gesmi Milcovich, Paolo Contessotto, Grazia Marsico, Siti Ismail, Abhay Pandit
Reactive oxygen species (ROS) are key pathological signals expressed in inflammatory diseases such as cancer, ischemic conditions and atherosclerosis. An ideal drug delivery system should not only be responsive to these signals but also should not elicit an unfavourable host response. This study presents an innovative platform for drug delivery where a natural/synthetic composite system composed of collagen type I and a synthesized polythioether, ensures a dual stimuli-responsive behaviour. Collagen type I is an extracellular matrix constituent protein, responsive to matrix metalloproteinases (MMP) cleavage per se...
October 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29030436/a-mutator-phenotype-promoting-the-emergence-of-spontaneous-oxidative-stress-resistant-mutants-in-campylobacter-jejuni
#17
Lei Dai, Orhan Sahin, Yizhi Tang, Qijing Zhang
Campylobacter jejuni is a leading cause of foodborne illnesses worldwide. As a microaerophilic organism, C. jejuni must be able to defend against oxidative stress encountered both in the host and in the environment. How Campylobacter utilizes a mutation-based mechanism for adaptation to oxidative stress is still unknown. Here we present a previously undescribed phenotypic and genetic mechanism that promotes the emergence of oxidative stress resistant mutants. Specifically, we showed that a naturally occurring mutator phenotype, resulting from a loss of function mutation in the DNA repair enzyme MutY, increased oxidative stress resistance (OX(R)) in C...
October 13, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29030232/a-novel-bone-targeting-delivery-system-carrying-phytomolecule-icaritin-for-prevention-of-steroid-associated-osteonecrosis-in-rats
#18
Shihui Chen, Lizhen Zheng, Jiayong Zhang, Heng Wu, Nan Wang, Wenxue Tong, Jiankun Xu, Le Huang, Yifeng Zhang, Zhijun Yang, Ge Lin, Xinluan Wang, Ling Qin
One of the effective strategies for prevention of steroid-associated osteonecrosis (SAON) is to inhibit bone resorption and fat formation and promote bone formation at osteonecrotic sensitive skeletal sites. We identified a novel phytomolecule that showed positive effects on osteogenesis, anti-bone resorption and anti-adipogenesis in vitro and also developed a bone-targeting delivery system (BTDS) for in vivo experimental study. The study investigated if our innovative synthesized BTDS carrying this phytomolecule would be able to effectively prevent SAON in a rat model...
October 10, 2017: Bone
https://www.readbyqxmd.com/read/29029813/innovative-therapy-monoclonal-antibodies-and-beyond
#19
M Di Nicola, L Apetoh, M Bellone, M P Colombo, G Dotti, S Ferrone, M Muscolini, J Hiscott, A Anichini, S M Pupa, F de Braud, M Del Vecchio
The seventh Edition of "Innovative Therapy, Monoclonal Antibodies and Beyond" Meeting took place in Milan, Italy, on January 27, 2017. The two sessions of the meeting were focused on: 1) Preclinical assays and novel biotargets; and 2) monoclonal antibodies, cell therapies and targeted molecules. Between these two sessions, a lecture entitled "HLA-antigens modulation and response to immune checkpoint inhibitor immunotherapy" was also presented. Despite the impressive successes in cancer immunotherapy in recent years, the response to immune based interventions occurs only in a minority of patients (∼20%)...
October 5, 2017: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/29029587/-here-if-you-need-me-exploring-peer-support-to-enhance-access-to-physical-health-care
#20
Julia Bocking, Stephanie B Ewart, Brenda Happell, Chris Platania-Phung, Robert Stanton, Brett Scholz
BACKGROUND: People diagnosed with mental illness (hereinafter "consumers") have higher rates of chronic disease and significantly shorter lives than the wider population. Peer workers have become increasingly involved in facilitating access to physical health care, yet the consumer perspective regarding peer involvement is unknown. This absent voice is needed to inform strategic planning and generate solutions to address the current inequity in health status. AIM: To articulate the views of consumers in regards to the potential use of peer workers to further the physical health of people with mental illness...
October 13, 2017: Journal of Mental Health
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