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https://www.readbyqxmd.com/read/28329727/theoretical-study-on-the-alkylation-of-o-xylene-with-styrene-in-alcl3-ionic-liquid-catalytic-system
#1
Bobo Cao, Jiuyao Du, Ziping Cao, Haitao Sun, Xuejun Sun, Hui Fu
To explore sustainable catalysts with innovative mechanisms, the alkylation mechanism of o-xylene with styrene was studied using DFT method in AlCl3-ionic liquid catalytic system. The reaction pathway was consisted of CC coupling and a hydrogen shift, in which two transition states were found and further discussed. The reactive energy catalyzed by superelectrophilic AlCl2(+) (12.6kcal/mol) was distinctly lower than AlCl3 (43.0kcal/mol), which was determined as the rate-determining step. Mulliken charge along IRC gave a comprehensive understanding of charge distribution and electron transfer in dynamic progress...
March 6, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28328946/a-randomized-clinical-trial-in-preterm-infants-on-the-effects-of-a-home-based-early-intervention-with-the-caretoy-system
#2
Giuseppina Sgandurra, Jakob Lorentzen, Emanuela Inguaggiato, Laura Bartalena, Elena Beani, Francesca Cecchi, Paolo Dario, Matteo Giampietri, Gorm Greisen, Anna Herskind, Jens Bo Nielsen, Giuseppe Rossi, Giovanni Cioni
CareToy system is an innovative tele-rehabilitative tool, useful in providing intensive, individualized, home-based, family-centred Early Intervention (EI) in infants. Our aim was to evaluate, through a Randomized Clinical Trial (RCT) study, the effects of CareToy intervention on early motor and visual development in preterm infants. 41 preterm infants (range age: 3.0-5.9 months of corrected age) were enrolled and randomized into two groups, CareToy and Standard Care. 19 infants randomized in CareToy group performed a 4-week CareToy program, while 22 allocated to control group completed 4 weeks of Standard Care...
2017: PloS One
https://www.readbyqxmd.com/read/28328490/the-coming-gray-tide-wanted-health-innovations-for-an-increasingly-older-population
#3
Leslie Mertz
The human population is getting older, and technology will play a key role in addressing the pressures this aging will place on healthcare systems. According to the 2015 United Nations' World Population Ageing report [1], the number of people worldwide 60 and older will increase from one in eight in 2015 to one in six by 2030 and to one in five by 2050; in Europe and "Northern America" (mainly the United States and Canada), those 60 and older will make up 25% of the population by 2030, and in Asia and Latin America, the number is predicted to be 17%...
March 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28327584/hybrid-core-shell-hycos-nanoparticles-produced-by-complex-coacervation-for-multimodal-applications
#4
D Vecchione, A M Grimaldi, E Forte, Paolo Bevilacqua, P A Netti, E Torino
Multimodal imaging probes can provide diagnostic information combining different imaging modalities. Nanoparticles (NPs) can contain two or more imaging tracers that allow several diagnostic techniques to be used simultaneously. In this work, a complex coacervation process to produce core-shell completely biocompatible polymeric nanoparticles (HyCoS) for multimodal imaging applications is described. Innovations on the traditional coacervation process are found in the control of the reaction temperature, allowing a speeding up of the reaction itself, and the production of a double-crosslinked system to improve the stability of the nanostructures in the presence of a clinically relevant contrast agent for MRI (Gd-DTPA)...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28327150/research-impact-of-systems-level-long-term-care-research-a-multiple-case-study
#5
Anita Kothari, Nedra Peter, Melissa Donskov, Tracy Luciani
BACKGROUND: Traditional reporting of research outcomes and impacts, which tends to focus on research product publications and grant success, does not capture the value, some contributions, or the complexity of research projects. The purpose of this study was to understand the contributions of five systems-level research projects as they were unfolding at the Bruyère Centre for Learning, Research and Innovation (CLRI) in long-term care (LTC) in Ottawa, Ontario, Canada. The research questions were, (1) How are partnerships with research end-users (policymakers, administrators and other public/private organisations) characterised? (2) How have interactions with the CLRI Management Committee and Steering Committee influenced the development of research products? (3) In what way have other activities, processes, unlinked actors or organisations been influenced by the research project activities? METHODS: The study was guided by Kok and Schuit's concept of research impacts, using a multiple case study design...
March 21, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28326990/native-and-non-native-perception-of-stress-in-mapudungun-assessing-structural-maintenance-in-the-phonology-of-an-endangered-language
#6
Benjamin J Molineaux
Today, virtually all speakers of Mapudungun (formerly Araucanian), an endangered language of Chile and Argentina, are bilingual in Spanish. As a result, the firmness of native speaker intuitions-especially regarding perceptually complex issues such as word-stress-has been called into question. Even though native intuitions are unavoidable in the investigation of stress position, efforts can be made in order to clarify what the actual sources of the intuitions are, and how consistent and 'native' they remain given the language's asymmetrical contact conditions...
March 2017: Language and Speech
https://www.readbyqxmd.com/read/28326418/combining-a-hip-arthroplasty-stem-with-trochanteric-reattachment-bolt-and-a-polyaxial-locking-plate-in-the-treatment-of-a-periprosthetic-fracture-below-a-well-integrated-implant
#7
Urban Hedlundh, Lars Karlsson
Distally anchored uncemented modular tapered porous stems are often the preferred treatment in total hip arthroplasty revisions and failed subtrochanteric fractures. These conditions mainly affect elderly osteoporotic patients, with an increased risk of later fractures below the well-fixated implant. Treatment in secondary fractures with long looking plates is the recommended treatment, where stability is a key to fracture healing. We report a complicated case in which this was achieved by an innovative technique combing the trochanteric attachment bolt of the stem system and a locking plate with polyaxial screws...
December 2016: Arthroplasty Today
https://www.readbyqxmd.com/read/28325490/development-and-application-of-a-new-in-line-coupling-of-a-miniaturized-boronate-affinity-monolithic-column-with-capillary-zone-electrophoresis-for-the-selective-enrichment-and-analysis-of-cis-diol-containing-compounds
#8
Maria Betzabeth Espina-Benitez, Jérôme Randon, Claire Demesmay, Vincent Dugas
An integrated, miniaturized and fully automated system was developed for the analysis (preconcentration/purification, separation and detection) of cis-diol containing molecules in complex matrices. This innovative in-line coupling system was achieved via the in-situ and localized synthesis of a short segment of silica-based monolith at the inlet of a 75-μm inner diameter fused silica capillary. The monolithic segment was locally functionalized with an acrylamide derivative of phenylboronic acid by free radical photopolymerization within 10min of irradiation time...
March 9, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28325242/radiation-oncology-in-india-challenges-and-opportunities
#9
REVIEW
Surbhi Grover, Shivakumar Gudi, Ajeet Kumar Gandhi, Priya M Puri, Adam C Olson, Danielle Rodin, Onyi Balogun, Preet K Dhillon, Daya Nand Sharma, Goura Kishor Rath, Shyam Kishore Shrivastava, Akila N Viswanathan, Umesh Mahantshetty
Rising cancer incidence and mortality in India emphasize the need to address the increasing burden of this disease and the stark inequities in access to radiotherapy and other essential medical treatments. State-of-the-art technology is available within the private sector and a few hospitals in the public sector, but 75% of patients in the public sector in India do not have access to timely radiotherapy. This inequity in access to radiotherapy in the public sector is amplified in rural areas, where most of India׳s population lives...
April 2017: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/28325241/radiation-oncology-in-the-developing-economies-of-central-and-eastern-europe
#10
REVIEW
Natia Esiashvili
Eastern Europe is represented by 22 countries of significant variability in population density and degree of economic development. They have been affected by past geopolitical isolation due to their association with the "Soviet Block." Currently, all Eastern European countries except Slovenia are low- or middle-income level and 10 of them are part of European Union. Health care systems in Central and Eastern Europe have been influenced by the legacy of centralized soviet-era governance; however, most countries, particularly in European Union zone, have gone through health care reforms directed toward modernizing infrastructure and staffing...
April 2017: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/28324968/improving-cardiopulmonary-resuscitation-cpr-outcomes-using-model-based-optimization
#11
Dieter Bender, Ali Jalali, C Nataraj
Cardiopulmonary Resuscitation (CPR) outcomes are far from optimal as practiced today, and prior work has documented that among probable reasons is the fact that the procedure remains to be fully understood. In an attempt to gain a broader understanding of the CPR physiology and the elemental principles underlying the CPR outcomes, this study proposes a novel approach. The analysis is carried out in three major steps. First, an appropriate cardiovascular system model was adopted and simulated using real CPR data as the input...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28323640/a-micro-scale-printable-nanoclip-for-electrical-stimulation-and-recording-in-small-nerves
#12
Charles A Lissandrello, Winthrop F Gillis, Jun Shen, Ben W Pearre, Flavia Vitale, Matteo Pasquali, Bradley J Holinski, Daniel J Chew, Alice E White, Timothy J Gardner
OBJECTIVE: The vision of bioelectronic medicine is to treat disease by modulating the signaling of visceral nerves near various end organs. In small animal models, the nerves of interest can have small diameters and limited surgical access. New high-resolution methods for building nerve interfaces are desirable. In this study, we present a novel nerve interface and demonstrate its use for stimulation and recording in small nerves. APPROACH: We design and fabricate micro-scale electrode-laden nanoclips capable of interfacing with nerves as small as 50 µm in diameter...
March 21, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28322303/a-new-electro-optical-approach-for-conductance-measurement-an-assay-for-the-study-of-drugs-acting-on-ligand-gated-ion-channels
#13
A Menegon, S Pitassi, N Mazzocchi, L Redaelli, R Rizzetto, J F Rolland, C Poli, M Imberti, A Lanati, F Grohovaz
Ligand gated ion channels are involved in many pathophysiological processes and represent a relevant, although challenging, target for drug discovery. We propose an innovative electro-optical approach to their analysis able to derive membrane conductance values from the local membrane potential changes imposed by test current pulses and measured by fast voltage-sensitive fluorescent dyes. We exploited the potential of this proprietary method by developing a drug testing system called "ionChannel Optical High-content Microscope" (ionChannelΩ)...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28321263/the-tree-drought-emission-monitor-tree-demon-an-innovative-system-for-assessing-biogenic-volatile-organic-compounds-emission-from-plants
#14
Marvin Lüpke, Rainer Steinbrecher, Michael Leuchner, Annette Menzel
BACKGROUND: Biogenic volatile organic compounds (BVOC) emitted by plants play an important role for ecological and physiological processes, for example as response to stressors. These emitted compounds are involved in chemical processes within the atmosphere and contribute to the formation of aerosols and ozone. Direct measurement of BVOC emissions requires a specialized sample system in order to obtain repeatable and comparable results. These systems need to be constructed carefully since BVOC measurements may be disturbed by several side effects, e...
2017: Plant Methods
https://www.readbyqxmd.com/read/28319856/systems-biology-solutions-for-biochemical-production-challenges
#15
REVIEW
Anne Sofie Lærke Hansen, Rebecca M Lennen, Nikolaus Sonnenschein, Markus J Herrgård
There is an urgent need to significantly accelerate the development of microbial cell factories to produce fuels and chemicals from renewable feedstocks in order to facilitate the transition to a biobased society. Methods commonly used within the field of systems biology including omics characterization, genome-scale metabolic modeling, and adaptive laboratory evolution can be readily deployed in metabolic engineering projects. However, high performance strains usually carry tens of genetic modifications and need to operate in challenging environmental conditions...
March 16, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28319764/electrofluid-hydrolysis-enhances-the-production-of-fermentable-sugars-from-corncob-via-in-reverse-phase-induced-voltage
#16
Fengfeng Wu, Yamei Jin, Dandan Li, Yuyi Zhou, Lunan Guo, Mengyue Zhang, Xueming Xu, Na Yang
To improve the economic value of lignocellulosic biomasses, an innovative electrofluidic technology has been applied to the efficient hydrolysis of corncob. The system combines fluidic reactors and induced voltages via magnetoelectric coupling effect. The excitation voltage had a positive impact on reducing sugar content (RSC). But, the increase of voltage frequency at 400-700Hz caused a slight decline of the RSC. Higher temperature limits the electrical effect on the hydrolysis at 70-80°C. The energy efficiency increased under the addition of metallic ions and series of in-phase induced voltage to promote hydrolysis...
March 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28319656/the-role-of-pulses-in-sustainable-and-healthy-food-systems
#17
REVIEW
John McDermott, Amanda J Wyatt
Improving nutrition is a development priority, particularly in low- and middle-income countries (LMICs) in Africa and South Asia, in which there is a persistent burden of undernutrition and increasing obesity. Healthy food systems can play a necessary role, aligned with other multisectoral actions, in addressing this challenge. Contributing to improved nutrition and health outcomes through food-based solutions is complex. In considering the role that pulses can play in addressing this challenge, there are useful conceptual frameworks and emerging lessons...
March 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28319448/rationale-and-design-of-a-phase-1-clinical-trial-to-evaluate-hsv-g207-alone-or-with-a-single-radiation-dose-in-children-with-progressive-or-recurrent-malignant-supratentorial-brain-tumors
#18
Alicia M Waters, James M Johnston, Alyssa T Reddy, John Fiveash, Avi Madan-Swain, Kara Kachurak, Asim K Bag, G Yancey Gillespie, James M Markert, Gregory K Friedman
Primary central nervous system tumors are the most common solid neoplasm of childhood and the leading cause of cancer-related death in pediatric patients. Survival rates for children with malignant supratentorial brain tumors are poor despite aggressive treatment with combinations of surgery, radiation, and chemotherapy, and survivors often suffer from damaging lifelong sequelae from current therapies. Novel innovative treatments are greatly needed. One promising new approach is the use of a genetically engineered, conditionally replicating herpes simplex virus (HSV) that has shown tumor-specific tropism and potential efficacy in the treatment of malignant brain tumors...
March 2017: Human Gene Therapy. Clinical Development
https://www.readbyqxmd.com/read/28318268/mechanistic-insights-into-the-directed-assembly-of-hydrogel-blocks-mediated-by-polyelectrolytes-or-microgels
#19
Nicolas Hanauer, Pierre Luc Latreille, Xavier Banquy
In this study, we report the directed assembly of hydrogel blocks mediated by electrostatic interactions. We compared two different assembly mechanisms, one mediated by microgel particles and another mediated by direct interaction between oppositely charged blocks. The system consisted in hydrogel blocks made of an interpenetrated network of (hydroxyethyl)methacrylate-poly(ethyleneglycol)dimethacrylate (HEMA-PEGDMA) and either positively charged polyethyleneimine (PEI) or negatively charged hyaluronic acid (HA)...
March 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28318021/corrigendum-adaptive-biomedical-innovation-evolving-our-global-system-to-sustainably-and-safely-bring-new-medicines-to-patients-in-need
#20
G Hirsch, M Trusheim, E Cobbs, M Bala, S Garner, D Hartman, K Isaacs, M Lumpkin, R Lim, K Oye, E Pezalla, P Saltonstall, H Selker
No abstract text is available yet for this article.
April 2017: Clinical Pharmacology and Therapeutics
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