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https://www.readbyqxmd.com/read/28938478/roux-en-y-gastric-bypass-surgery-has-unique-effects-on-postprandial-fgf21-but-not-fgf19-secretion
#1
Lydia-Ann L S Harris, Gordon I Smith, Bettina Mittendorfer, J Christopher Eagon, Adewole L Okunade, Bruce W Patterson, Samuel Klein
Context: Fibroblast growth factors (FGF) 19 and FGF21 are secreted by the intestine and liver in response to macronutrient intake. Intestinal resection and reconstruction via bariatric surgery may alter their regulation. Objective: We tested the hypothesis that weight loss induced by Roux-en-Y gastric bypass (RYGB) surgery, but not matched weight loss induced by laparoscopic adjustable gastric banding (LAGB), increases postprandial plasma FGF19 and FGF21 concentrations...
August 17, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28936585/understanding-intestinal-glucose-transporter-expression-in-obese-compared-to-non-obese-subjects
#2
Rebecca A Deal, Yueming Tang, Reid Fletcher, Alfonso Torquati, Philip Omotosho
INTRODUCTION: The impact of Roux-en-Y gastric bypass (RYGB) on weight loss and co-morbid disease resolution is well established. However, the mechanisms underlying the procedure remain incompletely understood. Intestinal remodeling involving glucose transporters (GLUTs) may play a crucial role. Rat studies have demonstrated morphological adaptation of GLUTs within adipose and intestinal cells in association with the reprogramming of glucose metabolism. There is a limited understanding of the variations in expression amongst GLUT family receptors in the human intestine...
September 21, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28936562/can-a-laparoscopic-roux-en-y-gastric-bypass-be-safely-performed-by-surgical-residents-in-a-bariatric-center-of-excellence-the-learning-curve-of-surgical-residents-in-bariatric-surgery
#3
Anne-Sophie van Rijswijk, Daan E Moes, Noëlle Geubbels, Barbara A Hutten, Yair I Z Acherman, Arnold W van de Laar, Maurits de Brauw, Sjoerd C Bruin
BACKGROUND: A learning curve (LC) is a graphic display of the number of consecutive procedures performed necessary to reach competence and is defined by complications and duration of surgery (DOS). There is little evidence on the LC of surgical residents in bariatric surgery. Aim of the study is to evaluate whether the laparoscopic Roux-en-Y gastric bypass (LRYGB) can be safely performed by surgical residents, to evaluate the LC of surgical residents for LRYGB and to assess whether surgical residents fit in the LC of the bariatric center which has been established by their proctors...
September 21, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28935201/gastric-pouch-emptying-of-solid-food-in-patients-with-successful-and-unsuccessful-weight-loss-after-roux-en-y-gastric-bypass-surgery
#4
Laura N Deden, Mellody I Cooiman, Edo O Aarts, Ignace M C Janssen, Martin Gotthardt, Baudewijn W Hendrickx, Frits J Berends
BACKGROUND: After Roux-en-Y gastric bypass (RYGB), approximately 10% of patients have insufficient weight loss (excess body mass index loss<50%). Gastric pouch emptying may have a role in weight loss. OBJECTIVES: To compare pouch emptying of patients with poor weight loss and patients with successful weight loss after RYGB. SETTING: A research-intensive nonacademic hospital and center of expertise in bariatric surgery in the Netherlands METHODS: Female patients were included from among patients with the least (poor weight loss group [P-WL]) and the most weight loss (successful weight loss group [S-WL]) in our center 2 years after RYGB...
August 12, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28935197/laparoscopic-heller-myotomy-after-previous-roux-en-y-gastric-bypass
#5
T Javier Birriel, Leonardo Claros, Maher El Chaar
No abstract text is available yet for this article.
August 25, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28933045/a-prospective-single-arm-trial-of-modified-long-biliopancreatic-and-short-alimentary-limbs-roux-en-y-gastric-bypass-in-type-2-diabetes-patients-with-mild-obesity
#6
Abdon José Murad, Ricardo Vitor Cohen, Eudes Paiva de Godoy, Christian Lamar Scheibe, Giuliano Peixoto Campelo, Almino Cardoso Ramos, Roclides Castro de Lima, Luís Eduardo Veras Pinto, Daniel Coelho, Hamilton Belo França Costa, Ígor Marreiros Pereira Pinto, Tiago Pereira, Francisco Raúl Santos Teófilo, José Aparecido Valadão
BACKGROUND: Type-2 diabetes (T2D) patients with body mass index (BMI) below 35 kg/m(2) carry lower remission rates than severely obese T2D individuals submitted to "standard limb lengths" Roux-en-Y gastric bypass (RYGB). Mild-obese patients appear to have more severe forms of T2D, where the mechanisms of glycemic control after a standard-RYGB may be insufficient. The elongation of the biliopancreatic limb may lead to greater stimulation of the distal intestine, alterations in bile acids and intestinal microbiota, among other mechanisms, leading to better metabolic outcomes...
September 20, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28933032/the-effect-of-dumping-on-weight-loss-in-conversion-of-failed-restrictive-surgery-a-cross-sectional-pilot-study
#7
Ruth Van Looveren, Yannick Mandeville, Pieter Logghe, Katrien Vandendriessche, Xander Verbeke, Patrick Vuylsteke, Paul Pattyn, Bart Smet
PURPOSE: Dumping is currently seen as a negative side effect of Roux-en-Y gastric bypass (RYGB). However, it may help patients to comply with their prescribed diet. In this study, we assess the role of dumping on weight loss in patients who have undergone conversion of failed restrictive surgery into RYGB. METHODS: An analysis was performed of 100 consecutive patients who underwent revisional RYGB (rRYGB) between 2006 and 2011 due to inadequate weight loss or band intolerance after laparoscopic adjustable gastric banding (LAGB)...
September 21, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28930514/weight-and-metabolic-outcomes-12-years-after-gastric-bypass
#8
Ted D Adams, Lance E Davidson, Sheldon E Litwin, Jaewhan Kim, Ronette L Kolotkin, M Nazeem Nanjee, Jonathan M Gutierrez, Sara J Frogley, Anna R Ibele, Eliot A Brinton, Paul N Hopkins, Rodrick McKinlay, Steven C Simper, Steven C Hunt
BACKGROUND: Few long-term or controlled studies of bariatric surgery have been conducted to date. We report the 12-year follow-up results of an observational, prospective study of Roux-en-Y gastric bypass that was conducted in the United States. METHODS: A total of 1156 patients with severe obesity comprised three groups: 418 patients who sought and underwent Roux-en-Y gastric bypass (surgery group), 417 patients who sought but did not undergo surgery (primarily for insurance reasons) (nonsurgery group 1), and 321 patients who did not seek surgery (nonsurgery group 2)...
September 21, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28929425/medium-term-outcomes-after-reversal-of-roux-en-y-gastric-bypass
#9
Gustavo Andrés Arman, J Himpens, R Bolckmans, D Van Compernolle, R Vilallonga, G Leman
BACKGROUND: Roux-en-Y gastric bypass (RYGB) can be reversed into normal anatomy (NA) or into sleeve gastrectomy (NASG) to address undesired side effects. Concomitant hiatal hernia repair (HHR) may be required. Before reversal, some patients benefit from placement of a gastrostomy, mostly to predict the result of recreating the native anatomy. METHODS: Retrospective study on mid-term effects of RYGB reversal to NA and NASG, including clinical and weight evolution, surgical complications, and incidence of gastro-esophageal reflux (GERD)...
September 19, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28929278/effect-and-mechanisms-of-diabetes-resolution-according-to-the-range-of-gastric-resection-and-the-length-of-anastomosis-in-animal-models-implication-for-gastric-cancer-surgery-in-patients-with-diabetes-mellitus
#10
Yeon-Ju Huh, Young-Gil Son, Tae-Han Kim, Ji-Ho Park, Tae-Jung Oh, Boram Choi, Jimin Min, Young Min Cho, Han-Kwang Yang, Hyuk-Joon Lee
BACKGROUND: To examine the effect and mechanism of Roux-en-Y gastric bypass (RYGB) on the improvement of diabetes according to the length of anastomosis and the gastric pouch volume in an animal model. METHODS: Glucose intolerance was induced with a high-fat diet for 3 months in Sprague-Dawley rats. The animals were subjected to conventional RYGB (cRYGB; 5% gastric pouch with 15-cm Roux limb, 40-cm biliopancreatic limb; n = 9), short-limb RYGB (sRYGB; 5%, 8, 4 cm; n = 9), fundus-sparing RYGB (fRYGB; 30%, 8, 4 cm; n = 9), or sham operation (n = 9)...
September 19, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28929218/percutaneous-gastric-remnant-gastrostomy-following-roux-en-y-gastric-bypass-surgery-a-single-tertiary-center-s-13-year-experience
#11
Shehbaz Hasam Shaikh, Justin Jay Stenz, David W McVinnie, James J Morrison, Todd Getzen, Arthur M Carlin, Farhaan R Mir
PURPOSE: The purpose of the study is to evaluate the indications, techniques, and outcomes for percutaneous gastrostomy placement in the gastric remnant following Roux-en-Y gastric bypass (RYGB) in bariatric patients. MATERIALS AND METHODS: Retrospective chart review and summary statistical analysis was performed on all RYGB patients that underwent attempted percutaneous remnant gastrostomy placement at our institution between April 2003 and November 2016. RESULTS: A total of 38 patients post-RYGB who underwent gastric remnant gastrostomy placement were identified, 32 women and 6 men, in which a total of 41 procedures were attempted...
September 19, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28928326/a-delayed-acute-complication-of-bariatric-surgery-gastric-remnant-haemorrhagic-ulcer-after-roux-en-y-gastric-bypass
#12
Stefan Patrascu, Carmen Balague Ponz, Sonia Fernandez Ananin, Eduardo M Targarona Soler
Acute gastric remnant bleeding is an exceptionally rare complication when it occurs long after bariatric surgery. We present the case of a patient with a bleeding ulcer of the excluded stomach (i.e., the remnant), occurring 7 years after Roux-en-Y gastric bypass (RYGB) for morbid obesity. A computed tomography scan managed to locate the active bleeding source in the gastric remnant. During emergency laparotomy, a bleeding ulcer of the fundic region of the excluded stomach was identified. Total resection of the remnant was performed, with good post-operative recovery...
September 20, 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/28927042/surgical-bypass-and-permanent-iodine-125-seed-implantation-vs-surgical-bypass-for-the-treatment-of-pancreatic-head-cancer
#13
Zhenjiang Zheng, Yinglong Xu, Shu Zhang, Guangchun Pu, Chi Cui
The present study aimed to investigate the efficacy and safety of Iodine-125 ((125)I) seed implantation in the treatment of locally advanced unresectable pancreatic head cancer. A prospective nonrandomized study was performed using data collected from patients between January 2009 and December 2012. A total of 34 patients underwent surgical bypass and permanent (125)I seed implantation (group A), and 32 patients underwent biliary and gastric bypass (group B). The preoperative variables, operative data, postoperative complications and follow-up information were examined...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28924918/adipocyte-size-and-leptin-receptor-expression-in-human-subcutaneous-adipose-tissue-after-roux-en-y-gastric-bypass
#14
Martha Tamez, Victoria Ramos-Barragan, Patricia Mendoza-Lorenzo, Pablo Arrieta-Joffe, Sergio López-Martínez, Martín E Rojano-Rodríguez, Mucio Moreno-Portillo, María E Frigolet
The molecular mechanisms implicated in pronounced weight loss and metabolic benefits after bariatric surgery are still unknown. Adipocyte phenotype and metabolism have not been entirely explored. However, some features of adipocyte function have been studied, such as adipocyte size and inflammation, which are both reduced after bariatric surgery. Adipocyte fat metabolism, which is partly regulated by leptin, is likely modified, since adipocyte area is decreased. Here, we show that leptin receptor expression is increased, while adipocyte size is decreased 8 months after Roux-en-Y gastric bypass...
September 18, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28924596/double-endoscopic-bypass-for-gastric-outlet-obstruction-and-biliary-obstruction
#15
Olaya I Brewer Gutierrez, Jose Nieto, Shayan Irani, Theodore James, Renata Pieratti Bueno, Yen-I Chen, Majidah Bukhari, Omid Sanaei, Vivek Kumbhari, Vikesh K Singh, Saowanee Ngamruengphong, Todd H Baron, Mouen A Khashab
BACKGROUND AND STUDY AIMS:  Double endoscopic bypass entails EUS-guided gastroenterostomy (EUS-GE) and EUS-guided biliary drainage (EUS-BD) in patients who present with gastric outlet and biliary obstruction. We report a multicenter experience with double endoscopic bypass. PATIENTS AND METHODS:  Retrospective, multicenter series involving 3 US centers. Patients who underwent double endoscopic bypass for malignant gastric and biliary obstruction from 1/2015 to 12/2016 were included...
September 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28921894/macrophage-area-content-and-phenotype-in-hepatic-and-adipose-tissue-in-patients-with-obesity-undergoing-roux-en-y-gastric-bypass
#16
Marianne D Kristensen, Michael T Lund, Merethe Hansen, Steen S Poulsen, Thorkil Ploug, Flemming Dela, Jørn W Helge, Clara Prats
OBJECTIVE: To investigate hepatic and adipose tissue macrophage content in subjects with obesity and the role of adipose tissue macrophages in weight loss-induced improved insulin sensitivity (IS). METHODS: A cross-sectional and a longitudinal study were combined to investigate the role of macrophages in subcutaneous (SAT) and visceral (VAT) adipose tissue and the liver in obesity-induced impaired IS and improvements with weight loss. Macrophage markers (CD68, CD163, and CD206) in SAT, VAT, and the liver from patients with obesity were investigated...
September 18, 2017: Obesity
https://www.readbyqxmd.com/read/28921422/high-incidence-of-secondary-hyperparathyroidism-in-bariatric-patients-comparing-different-procedures
#17
Jih-Hua Wei, Wei-Jei Lee, Keong Chong, Yi-Chih Lee, Shu-Chun Chen, Po-Hsun Huang, Shing-Jong Lin
BACKGROUND: Bariatric surgery is an effective therapy for morbid obesity but may reduce calcium absorption and significantly decrease the bone mineral density. This study examined the prevalence of secondary hyperparathyroidism (SHPT) in obese subjects during follow-up after different bariatric surgeries. We investigated predictors of SHPT. METHODS: We enrolled 1470 obese subjects undergoing bariatric/metabolic surgery with at least 1-year follow-up, including 322 patients undergoing Roux-en-Y gastric bypass (RYGB), 695 undergoing single anastomosis (mini-) gastric bypass (SAGB), 93 undergoing laparoscopic adjustable gastric banding (LAGB), and 360 undergoing sleeve gastrectomy (SG)...
September 18, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28919979/reversal-of-fibrosis-in-patients-with-nonalcoholic-steatohepatosis-after-gastric-bypass-surgery
#18
Brian M Parker, Jiang Wu, Jing You, David S Barnes, Lisa Yerian, John P Kirwan, Philip R Schauer, Daniel I Sessler
BACKGROUND: Roux-en-Y gastric bypass (RYGB) improves the pathophysiology that contributes to obesity-related nonalcoholic steatohepatitis (NASH). Whether obesity-related fibrosis improves is unclear. We hypothesized that RYGB reverses NASH and fibrosis, and indocyanine green (ICG) clearance provides a sensitive measure for detecting asymptomatic fatty liver disease. METHODS: One hundred six obese adults scheduled for RYGB had preoperative liver function assessed using standard tests and ICG clearance and core liver biopsies obtained during RYGB...
2017: BMC Obesity
https://www.readbyqxmd.com/read/28919184/clinical-significance-of-failure-to-lose-weight-10-years-after-roux-en-y-gastric-bypass
#19
Robert B Hawkins, J Hunter Mehaffey, Timothy L McMurry, Jennifer Kirby, Steven K Malin, Bruce Schirmer, Peter T Hallowell
BACKGROUND: Although Roux-en-Y gastric bypass (RYGB) induces short-term weight loss and co-morbidity amelioration, long-term data suggest that a subset of patients return to their preoperative body mass index (BMI). OBJECTIVES: To identify the clinical implications of 10-year weight loss failure after RYGB. SETTING: An academic teaching hospital. METHODS: Adults undergoing RYGB (1985-2004) were included in this study (n = 1087)...
August 9, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28919093/clip-closure-and-division-instead-of-stapling-for-the-last-small-gastric-bridge-between-gastric-pouch-and-remnant-stomach-in-laparoscopic-roux-en-y-gastric-bypass
#20
Adem Yuksel, Fatih Sumer, Cuneyt Kayaalp
INTRODUCTION: Here, a modification during gastric pouch forming was implemented in laparoscopic Roux-en-Y gastric bypass (LRYGB). We aimed to examine the feasibility of metallic clip closure for the remaining small stomach bridges (<1 cm) between the pouch and the remnant stomach. METHODS: During pouch creation, after the last stapler firing, the remaining small bridge was closed with clips and divided instead of using a new stapler. Metallic clips for this aim were used in 41 of 520 LRYGP between September 2010 and January 2017...
September 14, 2017: International Journal of Surgery
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