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https://www.readbyqxmd.com/read/29791782/obesity-leads-to-impairments-in-the-morphology-and-organization-of-human-skeletal-muscle-lipid-droplets-and-mitochondrial-networks-which-are-resolved-with-gastric-bypass-surgery-induced-improvements-in-insulin-sensitivity
#1
Marianne D Kristensen, Signe M Petersen, Kjestine E Møller, Michael T Lund, Merethe Hansen, Christina N Hansen, Julie Courraud, Jørn W Helge, Flemming Dela, Clara Prats
AIMS: Skeletal muscle lipid stores and mitochondrial function have been appointed as key players in obesity-induced insulin resistance. However, there are conflicting reports in the literature based on in vitro quantitative measurements. Here we test the hypothesis that it is not the quantity but the quality that matters. METHODS: The present study combines quantitative and qualitative structural measurements of lipid stores and mitochondrial dynamics in skeletal muscle from lean subjects, and subjects with morbid obesity, with and without type 2 diabetes, before and after gastric bypass surgery...
May 23, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29791656/long-term-maintenance-of-glucose-and-lipid-concentrations-after-roux-en-y-gastric-bypass
#2
Fernanda Cristina Carvalho Mattos Magno, Priscila Alves Medeiros de Sousa, Marcelo Paiva Rodrigues, Lícia Lopes Pio Pereira, José Egídio Paulo de Oliveira, Eliane Lopes Rosado, João Régis Ivar Carneiro
OBJECTIVE: Roux-en-Y gastric bypass (RYGB) reduces body weight and the comorbidities associated with obesity. The aim of this study was to evaluate whether glucose and lipid profiles were maintained during a 5-year follow-up period after RYGB. SUBJECTS AND METHODS: Anthropometric and laboratory data from 323 patients who had undergone this operation were analyzed. Differences in laboratory variables between the baseline and 12, 24, 36, 48 and 60 months postoperatively (PO) were assessed using a one-way ANOVA test to compare the three groups...
May 17, 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29790130/an-analysis-of-mid-term-complications-weight-loss-and-type-2-diabetes-resolution-of-stomach-intestinal-pylorus-sparing-surgery-sips-versus-roux-en-y-gastric-bypass-rygb-with-three-year-follow-up
#3
Austin Cottam, Daniel Cottam, Hinali Zaveri, Samuel Cottam, Amit Surve, Walter Medlin, Christina Richards
BACKGROUND: For many years, the Roux-en-Y Gastric Bypass (RYGB) was considered a good balance of complications and weight loss. According to several short-term studies, single anastomosis duodenal switch or stomach intestinal pylorus sparing surgery (SIPS) offers similar weight loss to RYGB with fewer complications and better diabetes resolution. No one has substantiated mid-term complication and nutritional differences between these two procedures. This paper seeks to compare complication and nutritional outcomes between RYGB and SIPS...
May 22, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29790128/evidence-that-the-length-of-bile-loop-determines-serum-bile-acid-concentration-and-glycemic-control-after-bariatric-surgery
#4
Adriana Mika, Lukasz Kaska, Monika Proczko-Stepaniak, Agnieszka Chomiczewska, Julian Swierczynski, Ryszard T Smolenski, Tomasz Sledzinski
BACKGROUND: Bariatric surgery contributes to the improvement in glucose metabolism that may be related to a postoperative increase in serum bile acids (BAs). Three commonly used types of bariatric procedures, laparoscopic sleeve gastrectomy (LSG) (without creation of a bile loop), Roux-en-Y gastric bypass (RYGB), and omega-loop gastric bypass (OLGB) (with creation of shorter 100-150 cm and longer 200-280 cm bile loops, respectively), differ in their effects on glycemic control. The aim of the study was to compare the effects of various bariatric procedures on serum BA concentration and glucose homeostasis...
May 22, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29786579/operative-treatment-of-corrosive-esophageal-strictures
#5
Volodymyr O Shaprynskyi, Yevhen V Shaprynskyi, Yaroslav V Karyi, Serhii A Lysenko, Oleg O Vorovskyi, Andrii I Semenenko
OBJECTIVE: Introduction: Nowadays operative treatment of corrosive esophageal strictures remains one of the difficult and unsolved problems in surgery. The level of postoperative complications such as anastomotic leak (develops in 7-30% of cases), infections, pneumonia, pleural empyema, mediastinitis, peritonitis, postoperative corrosive strictures is still rather high. The aim of our work was to improve the results of surgical treatment of patients with corrosive esophageal strictures by analyzing and refining on conservative therapy options as well as differentiated approach to each operative treatment method...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29782430/novel-technique-of-distal-roux-en-y-gastric-bypass-for-insufficient-weight-loss-after-primary-procedure-personal-experience-and-primary-results-at-12-months
#6
Theodoros Thomopoulos, Vincent Tomasi, Evangelos Koliakos, Maximilien Thoma, Benoit Navez
PURPOSE: In the literature, up to 20% of patients present a failure of weight loss after primary Roux-en-Y gastric bypass (RYGBP) or other restrictive procedures. Our aim is to describe the midterm results of our novel technique of distal Roux-en-Y gastric bypass (DRYGBP) as a revisional procedure. MATERIALS AND METHODS: We performed our DRYGBP in 30 patients. The length of the common channel was 100 cm, whereas the lengths of the alimentary and the biliopancreatic limbs were 2/3 and 1/3 of the remaining bowel, respectively...
May 18, 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29780857/multi-omic-network-based-interrogation-of-rat-liver-metabolism-following-gastric-bypass-surgery-featuring-swath-proteomics
#7
Gautham Vivek Sridharan, Matthew D'Alessandro, Shyam Sundhar Bale, Vicky Bhagat, Hugo Gagnon, John M Asara, Korkut Uygun, Martin L Yarmush, Nima Saeidi
Morbidly obese patients often elect for Roux-en-Y gastric bypass (RYGB), a form of bariatric surgery that triggers a remarkable 30% reduction in excess body weight and reversal of insulin resistance for those who are type II diabetic. A more complete understanding of the underlying molecular mechanisms that drive the complex metabolic reprogramming post-RYGB could lead to innovative non-invasive therapeutics that mimic the beneficial effects of the surgery, namely weight loss, achievement of glycemic control, or reversal of non-alcoholic steatohepatitis (NASH)...
September 2017: Technology
https://www.readbyqxmd.com/read/29778908/mammalian-target-of-rapamycin-complex-2-signaling-in-obese-women-changes-after-bariatric-surgery
#8
Marcela Augusta de Souza Pinhel, Carolina Ferreira Nicoletti, Natalia Yumi Noronha, Bruno Affonso Parenti de Oliveira, Cristiana Cortes-Oliveira, Wilson Salgado, Wilson Araujo da Silva, Doroteia Rossi Silva Souza, Julio Sergio Marchini, Carla Barbosa Nonino
OBJECTIVES: After bariatric surgery, modifications to signaling pathway networks including those of the metabolic regulator called mammalian or mechanistic target of rapamycin (mTOR) may lead to molecular alterations related to energy source availability, systemic nutrients, and catabolic and anabolic cellular processes. This study aimed to identify gene expression changes with regard to the mTOR complex 2 subunit signaling pathway in obese patients before and after bariatric surgery...
March 21, 2018: Nutrition
https://www.readbyqxmd.com/read/29776493/mechanisms-in-bariatric-surgery-gut-hormones-diabetes-resolution-and-weight-loss
#9
Jens Juul Holst, Sten Madsbad, Kirstine N Bojsen-Møller, Maria Saur Svane, Nils Bruun Jørgensen, Carsten Dirksen, Christoffer Martinussen
Gastric bypass surgery leads to profound changes in the secretion of gut hormones with effects on metabolism, appetite, and food intake. Here, we discuss their contributions to the improvement in glucose tolerance and the weight loss that results from the operations. We find that the improved glucose tolerance is due the following events: a negative energy balance and resulting weight loss, which improve first hepatic and later peripheral insulin sensitivity, in combination with increased postprandial insulin secretion elicited particularly by exaggerated glucagon-like peptide-1 responses...
May 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29776492/comment-on-adjustments-to-warfarin-dosing-after-gastric-bypass-and-sleeve-gastrectomy
#10
EDITORIAL
John K Saunders
No abstract text is available yet for this article.
May 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29772522/bariatric-surgery-drives-major-rearrangements-of-the-intestinal-microbiota-including-the-biofilm-composition
#11
Giuseppina Campisciano, Carolina Cason, Silvia Palmisano, Michela Giuricin, Alessia Rizzardi, Lory Saveria Croce, Nicolo De Manzini, Manola Comar
The intestinal microbiota disequilibrium has been associated with obesity, while the role of the gut mucosal biofilms in this pathology is still unknown. We analysed the changes in the intestinal microbiota of obese patients after bariatric surgery with the aim of disclosing the rearrangement of the biofilm configuration. Although the bariatric surgery drives major rearrangements of the gut microbiota, obese patients maintain the Prevotella enterotype before and after surgery, as shown by normal weight patients, with an increase of Bacteroides vulgatus and Bacteroides uniformis ...
June 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/29770925/esophageal-magnetic-sphincter-augmentation-as-a-novel-approach-to-post-bariatric-surgery-gastroesophageal-reflux-disease
#12
John P Kuckelman, Cody J Phillips, Michael J Derickson, Byron J Faler, Matthew J Martin
BACKGROUND: We sought to evaluate the safety and effectiveness of magnetic sphincter augmentation (MSA) in patients with GERD after bariatric surgery. METHODS: Pre- and post-operative GERD quality of life (G-QOL) surveys were conducted. Standard indications (SI) group or the post-bariatric group (PB) created. Outcomes were compared between groups. RESULTS: Twenty-eight patients analyzed with no losses to follow-up. All patients had preoperative testing confirming normal motility and presence of GERD...
May 16, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29770924/roux-en-y-gastric-bypass-surgery-induced-weight-loss-and-metabolic-improvements-are-similar-in-tgr5-deficient-and-wildtype-mice
#13
Zheng Hao, R Leigh Townsend, Michael B Mumphrey, Thomas W Gettys, Sangho Yu, Heike Münzberg, Christopher D Morrison, Hans-Rudolf Berthoud
BACKGROUND AND PURPOSE: Roux-en-Y gastric bypass surgery (RYGB) remains one of the most effective treatments for obesity and type 2 diabetes. Despite this, the mechanisms through which it acts are still not well understood. Bile acid signaling through the transmembrane G-protein-coupled receptor TGR5 has been shown to have significant effects on metabolism and has recently been reported to be necessary for the full effects of vertical sleeve gastrectomy (VSG), a bariatric surgery with similar effects to RYGB...
May 16, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29770188/retrograde-jejunojejunal-intussusception-in-a-pregnant-female-after-laparoscopic-roux-en-y-gastric-bypass
#14
Khuram Khan, Saqib Saeed, Amrita Persaud, Mohammad Sbeih, Sanjiv Gray, Leaque Ahmed
Adult intussusception is a rare complication after laparoscopic Roux-En-Y gastric bypass (LRYGB) surgery. Incidence of intussusception is on the rise as the demand of bariatric surgeries is increased to treat morbid obesity. Among the bariatric surgeries, LRYGB gastric bypass results in significantly higher weight loss with thinning of the mesentery resulting in increased risk for intussusception. Majority of intussusception cases after gastric bypass have been reported in non-pregnant patients. We report a case of retrograde jejunojejunal intussusception in 6 weeks pregnant female following laparoscopic gastric bypass, which was diagnosed with abdominal magnetic resonance imaging and managed successfully with resection and revision of the anastomosis...
May 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29768729/adaptive-changes-in-pancreas-post-roux-en-y-gastric-bypass-induced-weight-loss
#15
A Lautenbach, M Wernecke, N Riedel, J Veigel, J Yamamura, S Keller, R Jung, P Busch, O Mann, F K Knop, J J Holst, J J Meier, J Aberle
AIMS: Obesity has been shown to trigger adaptive increases in pancreas parenchymal and fat volume. Consecutively, pancreatic steatosis may lead to beta-cell dysfunction. However, it is not known, whether the pancreatic tissue components decrease with weight loss and pancreatic steatosis is reversible following RYGB. Therefore, the objective of the study was to investigate the effects of RYGB-induced weight loss on pancreatic volume and glucose homeostasis. MATERIALS AND METHODS: 11 patients were recruited in the Obesity Centre of the University Medical Centre Hamburg-Eppendorf...
May 16, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29766309/perioperative-outcomes-and-anesthetic-considerations-of-robotic-bariatric-surgery-in-a-propensity-matched-cohort-of-super-obese-and-super-super-obese-patients
#16
Katherine D Gray, Alfons Pomp, Gregory Dakin, Sonia Amanat, Zachary A Turnbull, Jon Samuels, Cheguevara Afaneh
BACKGROUND: The use of the robotic platform has not been well established in patients with super obesity (SO; body mass index, BMI ≥ 50) and super-super obesity (SSO, BMI ≥ 60). We aimed to determine safety and feasibility of robotic bariatric surgery in this cohort. METHODS: Review of a prospectively maintained database was performed of consecutive patients undergoing robotic bariatric surgery between 2015 and 2017. Propensity score analysis with 1:2 nearest neighbor matching was performed to control for baseline characteristics and procedure type...
May 15, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29766305/evaluation-of-vte-prophylaxis-and-the-impact-of-alternate-regimens-on-post-operative-bleeding-and-thrombotic-complications-following-bariatric-procedures
#17
Maria S Altieri, Jie Yang, Janos Hajagos, Konstantinos Spaniolas, Jihye Park, Antonios P Gasparis, Andrew T Bates, Salvatore Docimo, Mark Talamini, A Laurie Shroyer, Aurora D Pryor
BACKGROUND: Studies examining utilization and impact of venous thromboembolism (VTE) chemoprophylaxis for patients undergoing bariatric surgery are limited. Determination of the optimal prophylactic regimen to minimize complications is crucial. METHODS: The Cerner Health Facts database from 2003 to 2013 was queried using ICD-9 codes to identify patients undergoing laparoscopic sleeve gastrectomy (LSG) and Roux-en-Y gastric bypass (RYGB). VTE chemoprophylaxis regimens were divided into pre-operative alone (PreP), post-operative alone (PostP), both pre-operative and post-operative (PPP), or no prophylaxis (NP)...
May 15, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29764908/management-of-endocrine-disease-which-metabolic-procedure-comparing-outcomes-in-sleeve-gastrectomy-and-roux-en-y-gastric-bypass
#18
Adrian T Billeter, Javier de la Garza Herrera, Katharina M Scheurlen, Felix Nickel, Franck Billmann, Beat Müller-Stich
Obesity and its associated comorbidities have become one of the largest challenges for health care in the near future. Conservative therapy for obesity and related comorbidities have a very high failure rate and poor long-term results. Similarly, the conservative and medical management of the majority of metabolic diseases such as type 2 diabetes mellitus are only able to slow down disease progression but have no causal effect on the disease process. Obesity surgery has evolved as a highly effect therapy for severe obesity achieving long-lasting weight loss...
May 15, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29761876/differential-gip-glp-1-intestinal-cell-distribution-in-diabetics-yields-distinctive-rearrangements-depending-on-roux-en-y-biliopancreatic-limb-length
#19
António M Palha, Sofia S Pereira, Madalena M Costa, Tiago Morais, André F Maia, Marta Guimarães, Mário Nora, Mariana P Monteiro
As incretins are known to play an important role in type 2 diabetics (T2D) improvement observed after Roux-en-Y gastric bypass (RYGB), our aim was to assess whether increasing the length of RYGB biliopancreatic limb in T2D would modify the incretin staining cell density found after the gastric outlet. Small intestine biopsies (n = 38) were harvested during RYGB at two different distances from the duodenal angle; either 60-90 cm (n = 28), from non-diabetic (n = 18) patients, and T2D (n = 10), or 200 cm (n = 10) from T2D...
May 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29761262/correction-to-comparison-of-early-morbidity-and-mortality-between-sleeve-gastrectomy-and-gastric-bypass-in-high-risk-patients-for-liver-disease-analysis-of-american-college-of-surgeons-national-surgical-quality-improvement-program
#20
Mohamad A Minhem, Sali F Sarkis, Bassem Y Safadi, Souha A Fares, Ramzi S Alami
The authors regret that some of the article text, which was in the original manuscript and was intended for and addressed to the reviewers during the review process of this article, was mistakenly overlooked during the proofs stage and remains in the published article.
May 14, 2018: Obesity Surgery
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