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Suguru Shigemori, Masaki Ihara, Takashi Sato, Yoshinari Yamamoto, Shireen Nigar, Tasuku Ogita, Takeshi Shimosato
Interleukin 6 (IL-6) is an important pathogenic factor in development of various inflammatory and autoimmune diseases and cancer. Blocking antibodies against molecules associated with IL-6/IL-6 receptor signaling are an attractive candidate for the prevention or therapy of these diseases. In this study, we developed a genetically modified strain of Lactococcus lactis secreting a single-chain variable fragment antibody against mouse IL-6 (IL6scFv). An IL6scFv-secretion vector was constructed by cloning an IL6scFv gene fragment into a lactococcal secretion plasmid and was electroporated into L...
October 8, 2016: Applied Microbiology and Biotechnology
Murat Polat, Onder Ozcan, Leyla Sahan, Yasemin Üstündag-Budak, Murat Alisik, Nigar Yilmaz, Özcan Erel
OBJECTIVE: We aimed to investigate the short-term effect of laparoscopic surgery on serum thiol-disulfide homeostasis levels as a marker of oxidant stress of surgical trauma in elective laparoscopic cholecystectomy patients. MATERIALS AND METHODS: Venous blood samples were collected, and levels of native thiols, total thiols, and disulfides were determined with a novel automated assay. Total antioxidant capacity (measured as the ferric-reducing ability of plasma) and serum ischemia modified albumin, expressed as absorbance units assayed by the albumin cobalt binding test, were determined...
October 5, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
S M C George, A Vandersteen, E Nigar, D J P Ferguson, E J Topham, F M Pope
Ehlers-Danlos syndrome (EDS) encompasses a genetically and clinically heterogeneous group of connective tissue disorders, characterized by joint hypermobility, skin hyperextensibility and tissue fragility. It is a rare condition, and inheritance is either autosomal dominant or recessive. Previously grouped into 11 different subtypes, with increasing knowledge of the underlying molecular defects, it was reclassified in 1997 into 6 major groups, with type VIII excluded from this classification. Type VIII EDS is a very rare subtype, characterized by severe, early-onset periodontitis, skin fragility and abnormal scarring...
October 2016: Clinical and Experimental Dermatology
Nigar Dursun, Tugba Gokbel, Melike Akarsu, Erbil Dursun
OBJECTIVE: Physical therapy (PT) and botulinum toxin-A (BTX-A) injections are widely used in the treatment of spastic equinus foot due to cerebral palsy. The aim of this study was to show effects of intermittent serial casting (SC) in addition to standard treatment on spasticity, passive range of motion (PROM), and gait. DESIGN: Fifty-one ambulatory patients, treated by BTX-A to plantar flexor muscles, were randomly assigned to casting or control groups in a 2:1 ratio...
September 14, 2016: American Journal of Physical Medicine & Rehabilitation
Ilgin Sade, Murat İnanir, Suzan Şen, Esra Çakmak, Serkan Kablanoğlu, Barin Selçuk, Nigar Dursun
[Purpose] The primary aim of this study was to assess rehabilitation outcomes for early and two-stage repair of hand flexor tendon injuries. The secondary purpose of this study was to compare the findings between treatment groups. [Subjects and Methods] Twenty-three patients were included in this study. Early repair (n=14) and two-stage repair (n=9) groups were included in a rehabilitation program that used hand splints. This retrospective evaluated patients according to their demographic characteristics, including age, gender, injured hand, dominant hand, cause of injury, zone of injury, number of affected fingers, and accompanying injuries...
August 2016: Journal of Physical Therapy Science
Zarife Nigâr Özdemir-Kumral, Dilek Özbeyli, Ahmet Faruk Özdemir, M Buğra Karaaslan, Kübra Kaytaz, Mustafa F Kara, Olgu Enis Tok, Feriha Ercan, Berrak Ç Yeğen
INTRODUCTION: Despite its adverse health consequences, tobacco smoking is associated with lower incidence of several neurodegenerative and inflammatory diseases. The present study is aimed to show the effects of nicotine, major tobacco constituent, on five organs targeted by sepsis. METHODS: Male Wistar albino rats received tap water with (5 mg/kg) or without nicotine for 14 days. Under ketamine anesthesia, sepsis (n=50) was induced by ligation and punction of the cecum, while sham group (n=8) had only laparotomy...
August 3, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
Pete Driezen, Abu S Abdullah, Nigar Nargis, A K M Ghulam Hussain, Geoffrey T Fong, Mary E Thompson, Anne C K Quah, Steve Xu
This study assessed the knowledge of the harmful effects of tobacco use among vulnerable populations in Bangladesh and whether vulnerability was associated with the presence of complete home smoking bans. Data came from Wave 3 (2011-2012) of the International Tobacco Control (ITC) Bangladesh Survey, a nationally-representative survey of 3131 tobacco users and 2147 non-users. Socio-demographic measures of disadvantage were used as proxy measures of vulnerability, including sex, residential location, education and income...
2016: International Journal of Environmental Research and Public Health
Nigar Nargis, Yahya Manneh, Bakary Krubally, Baboucarr Jobe, Ahmed E Ogwell Ouma, Noureiny Tcha-Kondor, Evan H Blecher
OBJECTIVES: The objective of the present study was to evaluate how effective tobacco tax increase has been in increasing price of tobacco products and reducing tobacco consumption in the Gambia. In addition, it tests the hypothesis that tobacco tax revenue grows while tobacco consumption decreases as a result of tax and price increase. SETTING: The study is designed at the macroeconomic level to examine the import of tobacco products and revenue collected from tobacco taxation in a low-income setting...
2016: BMJ Open
Fuat Demirkiran, Veysel Sal, Tugan Bese, Nedim Tokgozoglu, Hakan Erenel, Nigar Sofiyeva, Ilker Kahramanoglu, Macit Arvas
The aim of this study was to evaluate the risk factors for recurrence of borderline ovarian tumours. This study investigated 127 women who were finally diagnosed with borderline epithelial ovarian tumours. Most of them were diagnosed in stage I (83.4%). With a median follow-up of 81.8 months (range: 14-205), the median time to recurrence was 22.4 months (range: 3-74). Five-year recurrence-free survival (RFS) and overall survival (OS) rates were 85.8% and 97.6%, respectively. In multivariate analysis, invasive implants and fertility-sparing surgery were found to be independent prognostic factors for 5-year RFS...
August 25, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Murat Atabey Ozer, Nihat Polat, Serkan Ozen, Tevfik Ogurel, Hakan Parlakpinar, Nigar Vardi
The aim of the current study was to evaluate the effect of apocynin (APO) on the development of proliferative vitreoretinopathy (PVR). New Zealand-type male rabbits were randomly grouped into three as follows: (1) Sham group rabbits which were applied intraperitoneal (i.p.) vehicle without PVR; (2) PVR group rabbits where PVR was created and an i.p. vehicle was administered for 21 successive days; (3) PVR + APO group rabbits where PVR was created and i.p. APO was administered for 21 successive days. Fundus examination was conducted with an indirect ophthalmoscope before starting the experiments and at each visit afterwards...
August 5, 2016: International Ophthalmology
Arif Ekiz, Zarife Nigâr Özdemir-Kumral, Mehmet Erşahin, Halil Tuğtepe, Ayliz Velioğlu Öğünç, Dilek Akakın, Demir Kıran, Derya Özsavcı, Necat Biber, Tayfun Hakan, Berrak Ç Yeğen, Göksel Şener, Hale Z Toklu
BACKGROUND & AIM: Alpha lipoic acid (LA) was shown to exert neuroprotection in trauma-induced spinal cord injury (SCI), which is frequently associated with urinary bladder complaints in patients with SCI. Accordingly, the protective effects of LA on biochemical and histological changes in bladder as well as functional studies were assessed. METHODS: Wistar albino rats were divided as control, SCI, and LA (50 mg/kg/day, ip) treated SCI groups (SCI+LA). The standard weight-drop (100 g/cm force at T10) method was used to induce a moderately severe SCI...
August 4, 2016: Neurourology and Urodynamics
Nihal Özdemir, Gülen Tüysüz, Nigar Çelik, Leman Yantri, Ethem Erginöz, Hilmi Apak, Alp Özkan, İnci Yıldız, Tiraje Celkan
AIM: An important life-threatening complication of intensive chemotherapy administered in children with leukemia is febrile neutropenia. The objective of this study was to evaluate the clinical features and consequences of febrile neutropenia attacks in children who were treated for acute lymphoblastic leukemia. MATERIAL AND METHODS: Nighty-six children who received chemotherapy for acute lymphoblastic leukemia in our center between January 1995 and December 2010 were included in the study...
June 2016: Türk Pediatri Arşivi
Nigar Yilmaz, Yasemin Ustundag, Seyda Kivrak, Serdar Kahvecioglu, Huseyin Celik, Ibrahim Kivrak, Kağan Huysal
BACKGROUND: The level and activity of indoleamine 2,3-dioxygenase (IDO) and the concentrations of L-tryptophan and its metabolite L-kynurenine were determined in association with various renal diseases. However, there have been no data regarding these parameters in patients on peritoneal dialysis compared to those undergoing hemodialysis or kidney transplantation. METHODS: This study investigated the level and activity of IDO and determined oxidative balance by calculating the total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI)...
September 2016: Renal Failure
Zarife Nigâr Özdemir Kumral, Meltem Kolgazi, Savaş Üstünova, Özgür Kasımay Çakır, Özge Dağdeviren Çevik, Göksel Şener, Berrak Ç Yeğen
Although endogenous estrogen is known to offer cardiac and vascular protection, the involvement of estrogen receptors in mediating the protective effect of estrogen on hypertension-induced cardiovascular and renal injury is not fully explained. We aimed to investigate the effects of estrogen receptor (ER) agonists on oxidative injury, cardiovascular and renal functions of rats with renovascular hypertension (RVH). Female Sprague-Dawley rats were randomly divided as control and RVH groups, and RVH groups had either ovariectomy (OVX) or sham-OVX...
2016: Clinical and Experimental Hypertension: CHE
Bradley C Johnston, Patricia A Miller, Arnav Agarwal, Sohail Mulla, Rabia Khokhar, Kyle De Oliveira, Christine L Hitchcock, Behnam Sadeghirad, Mukarram Mohiuddin, Nigar Sekercioglu, Michal Seweryn, Magdalena Koperny, Malgorzata M Bala, Thomasin Adams-Webber, Alicia Granados, Alaa Hamed, Mark W Crawford, Ans T van der Ploeg, Gordon H Guyatt
OBJECTIVES: To explore the responsiveness of patient reported outcomes (PROs) in interventional studies involving patients with rare lysosomal storage diseases (LSDs). STUDY DESIGN AND SETTING: We searched eight databases for experimental and non-experimental studies. Pairs of trained reviewers independently screened articles and subsequently extracted data from the eligible studies. Among studies with 10 or more patients employing a valid PRO, we assessed the responsiveness of PROs based on a re-analysis of the data using minimal important difference estimates...
July 2, 2016: Journal of Clinical Epidemiology
Emine Selva Sağlam, Miğraç Akçay, Dilşat Nigar Çolak, Kadriye İnan Bektaş, Ali Osman Beldüz
The Karaerik Cu mine is a worked-out deposit with large volumes of tailings and slags which were left around the mine site without any protection. Natural feeding of these material and run-off water from the mineralised zones into the Acısu effluent causes a serious environmental degradation and creation of acid mine drainage (AMD) along its entire length. This research aims at modelling the formation of AMD with a specific attempt on the characterisation of the bacterial population in association with AMD and their role on its occurrence...
September 2016: Extremophiles: Life Under Extreme Conditions
Nigar Sekercioglu, Lehana Thabane, Juan Pablo Díaz Martínez, Gihad Nesrallah, Christopher J Longo, Jason W Busse, Noori Akhtar-Danesh, Arnav Agarwal, Reem Al-Khalifah, Alfonso Iorio, Gordon H Guyatt
BACKGROUND: Chronic kidney disease-mineral and bone disorder (CKD-MBD) has been linked to poor health outcomes, including diminished quality and length of life. This condition is characterized by high phosphate levels and requires phosphate-lowering agents-phosphate binders. The objective of this systematic review is to compare the effects of available phosphate binders on patient-important outcomes in patients with CKD-MBD. METHODS: Data sources included MEDLINE and EMBASE Trials from 1996 to February 2016...
2016: PloS One
Emine Gerçek, Seher Sarıkaya Karabudak, Nigar Ardıç Çelik, Aynur Saruhan
AIMS AND OBJECTIVES: This study investigates the relationship between breastfeeding self-efficacy and LATCH scores and affecting factors in Turkish mothers. BACKGROUND: The benefits of breastfeeding for newborns and mothers are well-documented. Type of birth, maternal and neonatal complications, lack of support from healthcare professionals during breastfeeding, hospital routines, time and duration of mother-newborn attachment, and insufficiency of husband and family support are the most significant factors affecting breastfeeding initiation and mothers' breastfeeding self-efficacy in early postpartum period...
June 6, 2016: Journal of Clinical Nursing
Macit Arvas, Yavuz Salihoglu, Veysel Sal, Tayfun Gungor, Hamdullah Sozen, Ilker Kahramanoglu, Samet Topuz, Fuat Demirkiran, Cem Iyibozkurt, Tugan Bese, Burcin Salman Ozgu, Dogan Vatansever, Nedim Tokgozoglu, Sinan Berkman, Hasan Turan, Ergin Bengisu, Nigar Sofiyeva, Irem Demiral, Mutlu Meydanli
BACKGROUND: The purpose of this study was to determine the benefit of tertiary cytoreductive surgery (TC) for secondary recurrent epithelial ovarian cancer (EOC), focusing on whether optimal cytoreduction has an impact on disease-free survival, and whether certain patient characteristics could identify ideal candidates for TC. MATERIALS AND METHODS: Retrospective analysis of secondary recurrent EOC patients undergoing TC at three Turkish tertiary institutions from May 1997 to July 2014 was performed...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Nigar Sekercioglu, Jason W Busse, M Fatih Sekercioglu, Arnav Agarwal, Shaun Shaikh, Luciane Cruz Lopes, Reem A Mustafa, Gordon H Guyatt, Lehana Thabane
BACKGROUND: Chronic kidney disease-mineral and bone disorders (CKD-MBD) have been associated with poor health outcomes, including diminished quality and length of life. Standard management for CKD-MBD includes phosphate restricted diet, vitamin D and phosphate binders. Persistently elevated parathyroid hormone levels may require the addition of cinacalcet hydrochloride (cinacalcet), which sensitizes calcium receptors in the parathyroid gland. PURPOSE: The objective of this systematic review is to compare, in patients with CKD-MBD the effect of cinacalcet versus standard treatment on patient-important outcomes, including parathyroidectomy, fractures, hospitalizations due to cardiovascular events, cardiovascular mortality, all-cause mortality, and intermediate outcomes, in particular Kidney Disease Outcome Quality Initiative targets...
July 2016: Renal Failure
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