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https://www.readbyqxmd.com/read/27900560/serum-leptin-obestatin-and-ghrelin-levels-and-gastric-emptying-rates-of-liquid-and-solid-meals-in-non-obese-rats-with-roux-en-y-bypass-surgery-or-prosthesis-placement-implications-for-the-role-of-vagal-afferents
#1
Yunus Yavuz, Zarife Nigar Özdemir Kumral, Gülsün Memi, Özge Dağdeviren Çevik, Cumhur Yeğen, Berrak Ç Yeğen
BACKGROUND: The present study aimed to investigate the effects of Roux-en-Y gastric bypass (RYGB) and prosthesis placement on gastric emptying rate in conjunction with serum ghrelin-obestatin-leptin responses in non-obese rats with intact or denervated afferent innervation. METHODS: Under anesthesia, male Sprague-Dawley rats underwent either sham operation, RYGB, prosthesis, and/or Gregory cannula placement. Three weeks later, liquid or solid gastric emptying tests were performed and serum ghrelin, leptin and obestatin levels were measured...
November 29, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27897441/effects-of-molsidomine-on-retinopathy-and-oxidative-stress-induced-by-radiotheraphy-in-rat-eyes
#2
Murat Atabey Özer, Nihat Polat, Serkan Özen, Hakan Parlakpınar, Kemal Ekici, Alaaddin Polat, Nigar Vardı, Kevser Tanbek, Azibe Yildiz
PURPOSE: To determine the role of Molsidomine in preventing radiation-induced retinopathy after head and neck region irradiation of rats with a single radiation dose of 15 Gy. MATERIALS AND METHODS: Male Wistar albino rats were randomly grouped into five as follows: (1) control group rats, which were applied through an intraperitoneal (i.p.) vehicle without radiotherapy (RT); (2) RT group rats received a single dose of 15 Gy irradiation and after daily 0.1 ml vehicle i...
November 29, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27890978/patterns-of-use-and-perceptions-of-harm-of-smokeless-tobacco-in-navi-mumbai-india-and-dhaka-bangladesh
#3
Seema Mutti, Jessica L Reid, Prakash C Gupta, Mangesh S Pednekar, Gauri Dhumal, Nigar Nargis, Akm Ghulam Hussain, David Hammond
BACKGROUND: Globally, smokeless tobacco use is disproportionately concentrated in low-income and middle-income countries like India and Bangladesh. OBJECTIVES: The current study examined comparative patterns of use and perceptions of harm for different smokeless tobacco products among adults and youth in Navi Mumbai, India, and Dhaka, Bangladesh. METHODS: Face-to-face interviews were conducted on tablets with adult (19 years and older) smokeless tobacco users and youth (16-18 years) users and non-users in Navi Mumbai (n = 1002), and Dhaka (n = 1081)...
October 2016: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/27882101/effects-of-dexpanthenol-on-acetic-acid-induced-colitis-in-rats
#4
Yasir Furkan Cagin, Hakan Parlakpinar, Nigar Vardi, Alaadin Polat, Yahya Atayan, Mehmet Ali Erdogan, Kevser Tanbek
While the pathogenesis of acetic acid (AA)-induced colitis is unclear, reactive oxygen species are considered to have a significant effect. The aim of the present study was to elucidate the therapeutic potential of dexpanthenol (Dxp) on the amelioration of colitis in rats. Group I (n=8; control group) was intrarectally administered 1 ml saline solution (0.9%); group II [n=8; AA] was administered 4% AA into the colon via the rectum as a single dose for three consecutive days; group III (n=8; AA + Dxp) was administered AA at the same dosage as group II from day 4, and a single dose of Dxp was administered intraperitoneally; and group IV (n=8; Dxp) was administered Dxp similarly to Group III...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27823941/the-protonation-state-around-tyrd-tyrd-%C3%A2-in-photosystem-ii-is-reflected-in-its-biphasic-oxidation-kinetics
#5
Johannes Sjöholm, Felix Ho, Nigar Ahmadova, Katharina Brinkert, Leif Hammarström, Fikret Mamedov, Stenbjörn Styring
The tyrosine residue D2-Tyr160 (TyrD) in photosystem II (PSII) can be oxidized through charge equilibrium with the oxygen evolving complex in PSII. The kinetics of the electron transfer from TyrD has been followed using time-resolved EPR spectroscopy after triggering the oxidation of pre-reduced TyrD by a short laser flash. After its oxidation TyrD is observed as a neutral radical (TyrD(•)) indicating that the oxidation is coupled to a deprotonation event. The redox state of TyrD was reported to be determined by the two water positions identified in the crystal structure of PSII [Saito et al...
November 4, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27804080/a-critical-appraisal-of-chronic-kidney-disease-mineral-and-bone-disorders-clinical-practice-guidelines-using-the-agree-ii-instrument
#6
REVIEW
Nigar Sekercioglu, Reem Al-Khalifah, Joycelyne Efua Ewusie, Rosilene M Elias, Lehana Thabane, Jason W Busse, Noori Akhtar-Danesh, Alfonso Iorio, Tetsuya Isayama, Juan Pablo Díaz Martínez, Ivan D Florez, Gordon H Guyatt
BACKGROUND: Patients with chronic kidney disease mineral and bone disorders (CKD-MBD) suffer high rates of morbidity and mortality, in particular related to bone and cardiovascular outcomes. The management of CKD-MBD remains challenging. The objective of this systematic survey is to critically appraise clinical practice guidelines (CPGs) addressing CKD-MBD. METHODS/DESIGN: Data sources included MEDLINE, EMBASE, the National Guideline Clearinghouse, Guideline International Network and Turning Research into Practice up to May 2016...
November 1, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27803754/the-diagnostic-significance-of-signal-peptide-complement-c1r-c1s-uegf-and-bmp1-epidermal-growth-factor-domain-containing-protein-1-levels-in-pulmonary-embolism
#7
Nigar Dirican, Ali Duman, Gülcan Sağlam, Akif Arslan, Onder Ozturk, Sule Atalay, Ahmet Bircan, Ahmet Akkaya, Munire Cakir
BACKGROUND: Pulmonary embolism (PE) is a common and potentially life-threatening disorder. Patients with PE often have nonspecific symptoms, and the diagnosis is often delayed. AIM: The aim of our study was to investigate the role of signal peptide-complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 (SCUBE1) used in the diagnosis of PE. METHODS: The study was designed prospectively. A total of 57 patients who were admitted to emergency service with clinically suspected PE were included in the study...
October 2016: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/27799679/effect-of-mirror-therapy-on-upper-extremity-motor-function-in-stroke-patients-a-randomized-controlled-trial
#8
Nigar Gurbuz, Sevgi Ikbali Afsar, Sehri Ayaş, Sacide Nur Saracgil Cosar
[Purpose] This study aimed to evaluate the effectiveness of mirror therapy combined with a conventional rehabilitation program on upper extremity motor and functional recovery in stroke patients. [Subjects and Methods] Thirty-one hemiplegic patients were included. The patients were randomly assigned to a mirror (n=16) or conventional group (n=15). The patients in both groups underwent conventional therapy for 4 weeks (60-120 minutes/day, 5 days/week). The mirror group received mirror therapy, consisting of periodic flexion and extension movements of the wrist and fingers on the non-paralyzed side...
September 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27763979/is-more-cortical-bone-decortication-effective-on-guided-bone-augmentation
#9
Ahmet Hüseyin Acar, Hilal Alan, Cem Özgür, Nigar Vardi, Fatih Asutay, Çiğdem Güler
This study aims to evaluate the possible effect of more cortical bone decortication (CBD) on guided bone augmentation. A total of 16 New Zealand rabbits and 32 titanium domes were used. No cortical bone decortication was applied to the control group and in the study groups, the cortical bones were decorticated with a round burr (Group A: 1 hole with bleeding, Group B: 5 holes with bleeding, Group C: a thin layer of compact bone was completely removed with no bleeding). Then 2 titanium domes were placed on the calvarium of each rabbit with hydroxyapatite/beta-tricalcium phosphate...
October 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27722916/secretion-of-an-immunoreactive-single-chain-variable-fragment-antibody-against-mouse-interleukin-6-by-lactococcus-lactis
#10
Suguru Shigemori, Masaki Ihara, Takashi Sato, Yoshinari Yamamoto, Shireen Nigar, Tasuku Ogita, Takeshi Shimosato
Interleukin 6 (IL-6) is an important pathogenic factor in development of various inflammatory and autoimmune diseases and cancer. Blocking antibodies against molecules associated with IL-6/IL-6 receptor signaling are an attractive candidate for the prevention or therapy of these diseases. In this study, we developed a genetically modified strain of Lactococcus lactis secreting a single-chain variable fragment antibody against mouse IL-6 (IL6scFv). An IL6scFv-secretion vector was constructed by cloning an IL6scFv gene fragment into a lactococcal secretion plasmid and was electroporated into L...
October 8, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27705078/changes-in-thiol-disulfide-homeostasis-of-the-body-to-surgical-trauma-in-laparoscopic-cholecystectomy-patients
#11
Murat Polat, Onder Ozcan, Leyla Sahan, Yasemin Üstündag-Budak, Murat Alisik, Nigar Yilmaz, Özcan Erel
OBJECTIVE: We aimed to investigate the short-term effect of laparoscopic surgery on serum thiol-disulfide homeostasis levels as a marker of oxidant stress of surgical trauma in elective laparoscopic cholecystectomy patients. MATERIALS AND METHODS: Venous blood samples were collected, and levels of native thiols, total thiols, and disulfides were determined with a novel automated assay. Total antioxidant capacity (measured as the ferric-reducing ability of plasma) and serum ischemia modified albumin, expressed as absorbance units assayed by the albumin cobalt binding test, were determined...
October 5, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27663155/two-patients-with-ehlers-danlos-syndrome-type-viii-with-unexpected-hoarseness
#12
S M C George, A Vandersteen, E Nigar, D J P Ferguson, E J Topham, F M Pope
Ehlers-Danlos syndrome (EDS) encompasses a genetically and clinically heterogeneous group of connective tissue disorders, characterized by joint hypermobility, skin hyperextensibility and tissue fragility. It is a rare condition, and inheritance is either autosomal dominant or recessive. Previously grouped into 11 different subtypes, with increasing knowledge of the underlying molecular defects, it was reclassified in 1997 into 6 major groups, with type VIII excluded from this classification. Type VIII EDS is a very rare subtype, characterized by severe, early-onset periodontitis, skin fragility and abnormal scarring...
October 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27631386/a-randomized-controlled-trial-on-effectiveness-of-intermittent-serial-casting-on-spastic-equinus-foot-in-children-with-cerebral-palsy-after-botulinum-toxin-a-treatment
#13
Nigar Dursun, Tugba Gokbel, Melike Akarsu, Erbil Dursun
OBJECTIVE: Physical therapy (PT) and botulinum toxin-A (BTX-A) injections are widely used in the treatment of spastic equinus foot due to cerebral palsy. The aim of this study was to show effects of intermittent serial casting (SC) in addition to standard treatment on spasticity, passive range of motion (PROM), and gait. DESIGN: Fifty-one ambulatory patients, treated by BTX-A to plantar flexor muscles, were randomly assigned to casting or control groups in a 2:1 ratio...
September 14, 2016: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/27630400/rehabilitation-outcomes-in-patients-with-early-and-two-stage-reconstruction-of-flexor-tendon-injuries
#14
Ilgin Sade, Murat İnanir, Suzan Şen, Esra Çakmak, Serkan Kablanoğlu, Barin Selçuk, Nigar Dursun
[Purpose] The primary aim of this study was to assess rehabilitation outcomes for early and two-stage repair of hand flexor tendon injuries. The secondary purpose of this study was to compare the findings between treatment groups. [Subjects and Methods] Twenty-three patients were included in this study. Early repair (n=14) and two-stage repair (n=9) groups were included in a rehabilitation program that used hand splints. This retrospective evaluated patients according to their demographic characteristics, including age, gender, injured hand, dominant hand, cause of injury, zone of injury, number of affected fingers, and accompanying injuries...
August 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27613897/protective-effect-of-nicotine-on-sepsis-induced-oxidative-multi-organ-damage-role-of-neutrophils
#15
Zarife Nigâr Özdemir-Kumral, Dilek Özbeyli, Ahmet Faruk Özdemir, M Buğra Karaaslan, Kübra Kaytaz, Mustafa F Kara, Olgu Enis Tok, Feriha Ercan, Berrak Ç Yeğen
INTRODUCTION: Despite its adverse health consequences, tobacco smoking is associated with lower incidence of several neurodegenerative and inflammatory diseases. The present study is aimed to show the effects of nicotine, major tobacco constituent, on five organs targeted by sepsis. METHODS: Male Wistar albino rats received tap water with (5 mg/kg) or without nicotine for 14 days. Under ketamine anesthesia, sepsis (n=50) was induced by ligation and punction of the cecum, while sham group (n=8) had only laparotomy...
August 3, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/27571090/awareness-of-tobacco-related-health-harms-among-vulnerable-populations-in-bangladesh-findings-from-the-international-tobacco-control-itc-bangladesh-survey
#16
Pete Driezen, Abu S Abdullah, Nigar Nargis, A K M Ghulam Hussain, Geoffrey T Fong, Mary E Thompson, Anne C K Quah, Steve Xu
This study assessed the knowledge of the harmful effects of tobacco use among vulnerable populations in Bangladesh and whether vulnerability was associated with the presence of complete home smoking bans. Data came from Wave 3 (2011-2012) of the International Tobacco Control (ITC) Bangladesh Survey, a nationally-representative survey of 3131 tobacco users and 2147 non-users. Socio-demographic measures of disadvantage were used as proxy measures of vulnerability, including sex, residential location, education and income...
2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27566626/how-effective-has-tobacco-tax-increase-been-in-the-gambia-a-case-study-of-tobacco-control
#17
Nigar Nargis, Yahya Manneh, Bakary Krubally, Baboucarr Jobe, Ahmed E Ogwell Ouma, Noureiny Tcha-Kondor, Evan H Blecher
OBJECTIVES: The objective of the present study was to evaluate how effective tobacco tax increase has been in increasing price of tobacco products and reducing tobacco consumption in the Gambia. In addition, it tests the hypothesis that tobacco tax revenue grows while tobacco consumption decreases as a result of tax and price increase. SETTING: The study is designed at the macroeconomic level to examine the import of tobacco products and revenue collected from tobacco taxation in a low-income setting...
2016: BMJ Open
https://www.readbyqxmd.com/read/27559007/risk-factors-for-recurrence-of-borderline-ovarian-tumours-a-tertiary-centre-experience
#18
Fuat Demirkiran, Veysel Sal, Tugan Bese, Nedim Tokgozoglu, Hakan Erenel, Nigar Sofiyeva, Ilker Kahramanoglu, Macit Arvas
The aim of this study was to evaluate the risk factors for recurrence of borderline ovarian tumours. This study investigated 127 women who were finally diagnosed with borderline epithelial ovarian tumours. Most of them were diagnosed in stage I (83.4%). With a median follow-up of 81.8 months (range: 14-205), the median time to recurrence was 22.4 months (range: 3-74). Five-year recurrence-free survival (RFS) and overall survival (OS) rates were 85.8% and 97.6%, respectively. In multivariate analysis, invasive implants and fertility-sparing surgery were found to be independent prognostic factors for 5-year RFS...
August 25, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27495951/histopathological-and-ophthalmoscopic-evaluation-of-apocynin-on-experimental-proliferative-vitreoretinopathy-in-rabbit-eyes
#19
Murat Atabey Ozer, Nihat Polat, Serkan Ozen, Tevfik Ogurel, Hakan Parlakpinar, Nigar Vardi
The aim of the current study was to evaluate the effect of apocynin (APO) on the development of proliferative vitreoretinopathy (PVR). New Zealand-type male rabbits were randomly grouped into three as follows: (1) Sham group rabbits which were applied intraperitoneal (i.p.) vehicle without PVR; (2) PVR group rabbits where PVR was created and an i.p. vehicle was administered for 21 successive days; (3) PVR + APO group rabbits where PVR was created and i.p. APO was administered for 21 successive days. Fundus examination was conducted with an indirect ophthalmoscope before starting the experiments and at each visit afterwards...
August 5, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27490041/functional-and-structural-changes-of-the-urinary-bladder-following-spinal-cord-injury-treatment-with-alpha-lipoic-acid
#20
Arif Ekiz, Zarife Nigâr Özdemir-Kumral, Mehmet Erşahin, Halil Tuğtepe, Ayliz Velioğlu Öğünç, Dilek Akakın, Demir Kıran, Derya Özsavcı, Necat Biber, Tayfun Hakan, Berrak Ç Yeğen, Göksel Şener, Hale Z Toklu
BACKGROUND & AIM: Alpha lipoic acid (LA) was shown to exert neuroprotection in trauma-induced spinal cord injury (SCI), which is frequently associated with urinary bladder complaints in patients with SCI. Accordingly, the protective effects of LA on biochemical and histological changes in bladder as well as functional studies were assessed. METHODS: Wistar albino rats were divided as control, SCI, and LA (50 mg/kg/day, ip) treated SCI groups (SCI+LA). The standard weight-drop (100 g/cm force at T10) method was used to induce a moderately severe SCI...
August 4, 2016: Neurourology and Urodynamics
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