C Wiedemann, J J Whittaker, V H Pérez Carrillo, B Goretzki, M Dajka, F Tebbe, J-M Harder, P R Krajczy, B Joseph, F Hausch, A Guskov, U A Hellmich
Macrophage infectivity potentiator (MIP) proteins are widespread in human pathogens including Legionella pneumophila, the causative agent of Legionnaires' disease and protozoans such as Trypanosoma cruzi. All MIP proteins contain a FKBP (FK506 binding protein)-like prolyl-cis/trans-isomerase domain that hence presents an attractive drug target. Some MIPs such as the Legionella pneumophila protein (LpMIP) have additional appendage domains of mostly unknown function. In full-length, homodimeric LpMIP, the N-terminal dimerization domain is linked to the FKBP-like domain via a long, free-standing stalk helix...
August 24, 2023: International Journal of Biological Macromolecules