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https://www.readbyqxmd.com/read/29456953/histopathological-analysis-of-the-effects-of-corticosteroids-on-vocal-cords-experimental-study
#1
Ziya Salturk, Tolgar Lütfi Kumral, Gürcan Sunnetçi, Yavuz Atar, Çağlar Çakır, Güven Yıldırım, Güler Berkiten, Yavuz Uyar
Local treatment with corticosteroids results in side effects involving the upper respiratory tract including candidiasis, sore throat, and dysphonia. Although these effects are well known, they have not been evaluated using a histopathological approach. This study investigated the histopathological aspects of steroid-induced dysphonia. A total of 16 female Wistar albino rats were divided into two groups. The eight rats in the experimental group were given an inhaled dose of mometasone furoate daily for 4 weeks...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29426723/topical-therapy-for-refractory-rhinosinusitis-caused-by-methicillin-resistant-staphylococcus-aureus-first-report-in-a-prospective-series
#2
Alan H Shikani, Nadim Khoueir, Mary Ann Jabra-Rizk, Henry J Shikani, Randall J Basaraba, Jeff G Leid
OBJECTIVE: The incidence of refractory chronic rhinosinusitis (CRS) associated with methicillin-resistant Staphylococcus aureus (MRSA) is rising and remains a therapeutic challenge. The goal of this study is to demonstrate the efficacy of a non-invasive topical therapy against MRSA in these patients. METHODS: Seventeen patients with refractory CRS caused by MRSA were treated with a topical therapy protocol. Treatment consisted of weekly endoscopic sinus debridement followed by intra-sinus installation of a hydroxyl-ethylcellulose gel that releases mometasone and a culture-directed antibiotic for a period of 6 weeks, along with daily nasal nebulization of mometasone with the same antibiotic and saline rinses...
February 6, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29421985/mometasone-furoate-inhibits-growth-of-acute-leukemia-cells-in-childhood-by-regulating-pi3k-signaling-pathway
#3
Xiaojing Wang, Jianli Shi, Deqiang Gong
OBJECTIVES: Acute lymphoblastic leukemia (ALL) is the most common cancer before the age of 15 years, seriously endangering the health of children. The main treatment for Childhood ALL was pharmacotherapy. But these drugs have many side effects and some of them could develop drug resistance quickly. Mometasone furoate (MF) is an efficient glucocorticoid for topical treatment of inflammation on the skin, lung and nose. METHODS: In this study, we investigated whether the MF had effects on ALL cells proliferation and migration...
February 8, 2018: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29411351/comparative-safety-and-efficacy-of-topical-mometasone-furoate-with-other-topical-corticosteroids
#4
REVIEW
Fabrizio Spada, Tanya M Barnes, Kerryn A Greive
Derivatives of hydrocortisone, such as mometasone furoate, a (2') furoate-17 ester with chlorine substitutions at positions 9 and 21, have been designed to improve efficacy and reduce the incidence of adverse effects. An extensive literature search of MEDLINE, Embase and other databases was conducted to review the safety and efficacy of various formulations of topical mometasone furoate. Mometasone furoate exhibits high potency with greater anti-inflammatory activity and a longer duration of action than betamethasone...
February 7, 2018: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/29394004/corticosteroid-nasal-irrigations-are-more-effective-than-simple-sprays-in-a-randomized-double-blinded-placebo-controlled-trial-for-chronic-rhinosinusitis-after-sinus-surgery
#5
Richard J Harvey, Kornkiat Snidvongs, Larry H Kalish, Gretchen M Oakley, Raymond Sacks
BACKGROUND: Persistent mucosal inflammation in patients with chronic rhinosinusitis (CRS) often results in ongoing symptoms, recurrence of polypoid mucosa, infective exacerbations, and further systemic medication despite surgical intervention. Debate exists as to the most effective topical therapy in CRS. METHODS: The objective was to determine if corticosteroid delivered via a nasal irrigation or via a simple nasal spray would be more effective in controlling the symptoms and signs of CRS...
February 2, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29350840/a-phase-3-trial-of-mometasone-furoate-sinus-implants-for-chronic-sinusitis-with-recurrent-nasal-polyps
#6
Robert C Kern, J Pablo Stolovitzky, Stacey L Silvers, Ameet Singh, Jivianne T Lee, David M Yen, Alfred M C Iloreta, Francis P J Langford, Boris Karanfilov, Keith E Matheny, James W Stambaugh, Anna K Gawlicka
BACKGROUND: Topical intranasal corticosteroid sprays (INCSs) are standard treatment for nasal polyps (NPs), but their efficacy is reduced by poor patient compliance and impaired access of drug to the sinus mucosa. A corticosteroid-eluting sinus implant was designed to address these limitations in patients with recurrent polyposis after sinus surgery by delivering 1350 μg of mometasone furoate (MF) directly to the ethmoid sinus mucosa over approximately 90 days. METHODS: A randomized, sham-controlled, double-blind trial was undertaken in 300 adults with refractory chronic rhinosinusitis with NPs (CRSwNP), who were candidates for repeat surgery...
January 19, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29331580/local-delivery-of-mometasone-furoate-from-an-eluting-endotracheal-tube
#7
Abu Ammar Aiman, Maayan Gruber, Patrick Martin, Ohad Stern, Forsan Jahshan, Offir Ertracht, Eyal Sela, Samer Srouji, Eyal Zussman
Laryngeal and tracheal morbidity is a common complication of endotracheal tube (ETT)-based airway management, and manifests as local irritation, inflammation, and edema. Systemic corticosteroids are commonly administered to manage these conditions; however, their efficacy is inadequate and limited by potential severe side effects. In the present study, a steroid delivery system for local therapy was developed to generate relatively high local drug concentrations and to improve drug efficacy. ETTs were coated with electrospun poly (lactic-co-glycolic acid) (PLGA) nanofibers loaded with mometasone furoate (MF), creating a microscale thick layer...
January 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29306232/evaluation-of-the-effects-of-montelukast-mometasone-furoate-and-combined-therapyon-adenoid-size-a-randomized-prospective-clinical-trial-with-objective-data
#8
Birgül Tuhanıoğlu, Sanem Okşan Erkan
Background/aim: The incidence of adenoid hypertrophy is 2%-3% in children. Adenoidectomy is a commonly performed procedure in children that may cause complications such as early or late bleeding (4%-5%), recurrence of adenoid tissue (10%-20%), and postoperative respiratory problems (27%). Therefore, medical therapy alternatives to adenoidectomy are important and must be tried before surgery. In this study, we investigated the efficacy of mometasone furoate, montelukast, and a combination of these drugs in pediatric patients with adenoid hypertrophy who were scheduled for reduction with medical therapy after not being recommended for surgery...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29300842/validated-stability-indicating-methods-for-determination-of-mometasone-furoate-in-presence-of-its-alkaline-degradation-product
#9
Rania A Sayed, Manal M El-Masri, Wafaa S Hassan, Magda Y El-Mammli, Abadalla Shalaby
Two novel stability-indicating TLC densitometric and chemometric methods were developed for the determination of mometasone furoate (MF) in the presence of its alkaline degradation product (MF Deg). The developed TLC densitometric method (Method A) is based on the quantitative densitometric separation of MF from its alkaline degradation product on silica gel 60 F254 and measurement of the bands at 250 nm. The separation was carried out using hexane-chloroform-methanol-acetonitrile (6:6:1:0.3, by volume) as a developing system...
December 29, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29236657/psoriasiform-hailey-hailey-disease-presenting-as-erythematous-psoriasiform-plaques-throughout-the-body-a-case-report
#10
Jonathan Ni, Kathleen E Gilbert, Ivie F Manalo, Jashin J Wu
INTRODUCTION: Hailey-Hailey disease is an adult-onset skin condition characterized by lesions in the intertriginous regions of the body. The lesions can be pruritic, painful, and associated with physical and social impairment. CASE PRESENTATION: We present a case of psoriasiform Hailey-Hailey disease in a 60-year-old white woman who exhibited erythematous psoriasiform plaques in many areas of her body. The patient's condition was successfully treated with a twice-daily regimen of doxycycline, mometasone, and clindamycin...
2017: Permanente Journal
https://www.readbyqxmd.com/read/29193637/use-of-adapalene-in-alopecia-areata-efficacy-and-safety-of-mometasone-furoate-0-1-cream-versus-combination-of-mometasone-furoate-0-1-cream-and-adapalene-0-1-gel-in-alopecia-areata
#11
Mehmet Unal
Alopecia areata (AA) is an autoimmune disease characterized by non-cicatricial hair loss. No definitive therapy currently exists for AA. To compared the efficacy and safety of the mometasone furoate 0.1% cream alone with the mometasone furoate 0.1% cream plus adapalene 0.1% gel in treatment of AA. Twenty patients with AA and with mean age of 27.4 ± 9.2 years were enrolled. Patches with a diameter of < 5 cm were treated with mometasone furate 0.1% cream (M), and patches with a diameter of ≥5 cm were treated with mometasone furate 0...
November 28, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/29177053/evaluation-of-a-single-administration-ototopical-treatment-for-canine-otitis-externa-a-randomised-trial
#12
John Blake, Daniel Keil, Kenneth Kwochka, Kathleen Palma, Jennifer Schofield
Objective: To evaluate the efficacy and safety of a new, single-administration Otic Solution containing florfenicol, terbinafine and mometasone furoate for the treatment of canine otitis externa (OE). Design: The clinical efficacy and safety study was a multicentre, controlled, masked and randomised field study conducted over 30 days. Two hundred and twenty-one (221) client-owned dogs of varying breeds with diagnosed bacterial and/or fungal OE were enrolled. Procedure: Dogs were randomised to either Otic Solution or control groups...
2017: Veterinary Record Open
https://www.readbyqxmd.com/read/29168468/strontium-chloride-hexahydrate-as-a-candidate-molecule-for-long-term-treatment-of-allergic-rhinitis
#13
Emine Elif Altuntas, Nergiz Hacer Turgut, Kasım Durmuş, Ömer Tamer Doǧan, Melih Akyol
BACKGROUND & OBJECTIVES: Neurogenic inflammation plays a role in the pathophysiology of allergic rhinitis (AR). Strontium salts are highly effective in reducing the sensory irritation. This study was aimed to investigate the efficacy of strontium chloride (SC) on AR symptoms based on the duration of SC use before the symptoms begin. METHODS: Wistar albino rats (n=18) were randomly divided into three groups: Group 1, received 1μg mometasone furoate (MF); Group 2, three per cent SC; and Group 3 received five per cent SC (2 μl/site)...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29164323/safety-of-intranasal-corticosteroid-sprays-during-pregnancy-an-updated-review
#14
REVIEW
Ahmed H Alhussien, Riyadh A Alhedaithy, Saad A Alsaleh
INTRODUCTION: Rhinitis and rhinosinusitis are commonly encountered in pregnant women. Intranasal corticosteroid (INCS) sprays are generally safe and effective in the treatment of these conditions in the general population. However, the use of some of these INCS sprays during pregnancy is still controversial. OBJECTIVE: To review the current literature about the safety of intranasal corticosteroid sprays during pregnancy. METHODOLOGY: Using different search engines, each type of INCS was reviewed separately (triamcinolone, beclomethasone, budesonide, fluticasone propionate, fluticasone furoate, mometasone, and ciclesonide)...
November 21, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29151650/molecular-modeling-of-cloned-bacillus-subtilis-keratinase-and-its-insinuation-in-psoriasis-treatment-using-docking-studies
#15
Sonali Gupta, Parul Tewatia, Jyoti Misri, Rajni Singh
Present study demonstrated the expression of cloned Bacillus subtilis RSE163 keratinase gene and in silico binding affinities of deduced protein with psoriasis topical drugs for systemic absorption and permeation through skin. The ker gene expressed in E. coli showed significantly higher keratinase activity 450 ± 10.43 U representing 1342 bp nucleotides encoding 447 amino acids with molecular weight of 46 kDa. The modeled structure was validated using ramachandran's plot showing 305 residues (84.3%) in most favoured region...
December 2017: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/29098299/safety-and-effectiveness-of-a-bioabsorbable-steroid-releasing-implant-for-the-paranasal-sinus-ostia-a-randomized-clinical-trial
#16
Amber Luong, Randall A Ow, Ameet Singh, Robert L Weiss, Joseph K Han, Roland Gerencer, J Pablo Stolovitzky, James W Stambaugh, Aarthi Raman
Importance: Suboptimal outcomes of endoscopic sinus surgery (ESS) are often associated with restenosis and inflammation of frontal sinus ostia. Steroid-releasing sinus implants have been shown to maintain sinus patency by minimizing inflammation and scar tissue formation. An hourglass-shaped, bioabsorbable, steroid-releasing implant was developed to provide mechanical support and optimize drug delivery to paranasal sinus ostia. Objective: To assess the safety and efficacy of the hourglass-shaped, bioabsorbable, steroid-releasing sinus implant in improving postoperative outcomes when placed in the frontal sinus ostia (FSO) following ESS in patients with chronic rhinosinusitis (CRS)...
November 2, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29072663/-the-effectiveness-of-the-combination-of-azelastine-hydrochloride-and-mometasone-furoate-for-the-intranasal-application-in-the-patients-presenting-with-seasonal-allergic-rhinitis
#17
S A Karpishchenko, O M Kolesnikova
The objective of the present work was to evaluate the effectiveness of the combination of azelastine hydrochloride and mometasone furoate for the intranasal application to treat the patients presenting with seasonal allergic rhinitis. A total of 60 subjects suffering from seasonal allergic rhinitis were available for the observation. All the patients were allocated to three groups comprised of 20 individuals each. The patients of the first group received the fixed combination of azelastine hydrochloride and mometasone furoate for the intranasal application, those in the second group were given mometasone furoate administered intranasally together with an oral antihistamine preparation of the third generation, and the patients of the third group were treated with intranasal mometasone furoate alone...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/29058247/therapeutic-effects-of-different-drugs-on-obstructive-sleep-apnea-hypopnea-syndrome-in-children
#18
Jing Zhang, Jie Chen, Yong Yin, Lei Zhang, Hao Zhang
BACKGROUND: This study aimed to compare the therapeutic effects of different drugs on obstructive sleep apnea/hypopnea syndrome (OSAHS) in children by using a network meta-analysis approach. METHODS: PubMed, Embase and Cochrane Library were searched from the inception of each database to November 2015. Randomized controlled trials (RCTs) concerning the comparisons in the therapeutic effects of eight placebo-controlled drugs on OSAHS in children were included in this study...
December 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29050445/what-s-new-in-the-treatment-of-eczemas
#19
Massimo Gola, Antonio Carpentieri, Francesco Loconsole
BACKGROUND: We have conducted an open label, non-comparative study in order to assess the efficacy and tolerability of Dexyane Med in combination with corticosteroids in patients with chronic hand eczema (CHE) and contact eczema (CE) in a real-life setting. METHODS: Twenty patients, 10 with CHE and 10 with CE, have been enrolled in the study. After the enrollment and the baseline evaluation, patients were treated with topical mometasone once daily and Dexyane Med once daily for one week, followed by Dexyane Med twice daily for three weeks...
December 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29035825/effect-of-a-combination-of-mometasone-furoate-levofloxacin-and-retinyl-palmitate-with-an-in-situ-gel-forming-nasal-delivery-system-on-nasal-mucosa-damage-repair-in-an-experimental-rabbit-model
#20
Fadlullah Aksoy, Remzi Dogan, Orhan Ozturan, Ebru Altuntas, Fatma Gülgün Yener, Gulactı Topcu, Beril Guler
BACKGROUND: In this study a combination of Mometasone Furoate (MF)+Levofloxacin hemihydrate (LH)+Retinyl palmitate (RP) with an in situ gel-forming delivery system was evaluated at different stages of nasal mucosal damage repair in a rabbit maxillary sinus model. METHODS: In this study, 28 rabbits were included and assigned randomly to four groups. In all rabbits, a standard ostium was opened in the medial wall of the maxillary sinus by using a drill. Two different subsequently prepared gels with an in situ gel-forming delivery system were used...
October 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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