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https://www.readbyqxmd.com/read/28817781/availability-and-variation-of-publicly-reported-prescription-drug-prices
#1
Jeffrey T Kullgren, Joel E Segel, Timothy A Peterson, A Mark Fendrick, Simone Singh
OBJECTIVES: To examine how often retail prices for prescription drugs are available on state public reporting websites, the variability of these reported prices, and zip code characteristics associated with greater price variation. STUDY DESIGN: Searches of state government-operated websites in Michigan, Missouri, New York, and Pennsylvania for retail prices for Advair Diskus (250/50 fluticasone propionate/salmeterol), Lyrica (pregabalin 50 mg), Nasonex (mometasone 50 mcg nasal spray), Spiriva (tiotropium 18 mcg cp-handihaler), Zetia (ezetimibe 10 mg), atorvastatin 20 mg, and metoprolol 50 mg...
July 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28814353/pre-and-postoperative-blood-neutrophil-to-lymphocyte-and-eosinophil-to-lymphocyte-ratios-in-patients-with-sinonasal-polyps-a-preliminary-investigation
#2
Giuseppe Brescia, Umberto Barion, Claudia Zanotti, Daniela Parrino, Gino Marioni
BACKGROUND: Identifying specific endotypes within the broad picture of chronic rhinosinusitis with nasal polyps (CRSwNP), by using biomarkers for instance, remains a challenge. The prognostic role of the neutrophil-to-lymphocyte ratio (NLR) and the eosinophil-to-lymphocyte ratio (ELR) as potential markers of inflammation has already been discussed. OBJECTIVE: The aim of the present study was to compare NLR and ELR before and after endoscopic sinus surgery (ESS) and nasal mometasone furoate for CRSwNP by stratifying patients by their clinical and histologic features...
September 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28802371/how-can-we-improve-medical-adherence-to-intranasal-corticosteroids-in-children
#3
Emre Ocak, Deniz Kocaoz, Baran Acar
OBJECTIVE: To evaluate the factors which may be related to nonadherence to intranasal corticosteroids (ICS) in the treatment of allergic rhinitis (AR) in children. METHODS: A prospective study was conducted on children with AR diagnosis in a tertiary referral hospital. All participants were provided with mometasone furoate nasal sprays for 30 days after the diagnosis. Caregivers were called back when the therapy was over and completed a questionnaire about the factors that may influence the adherence to the treatment...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28799097/predicting-pulmonary-pharmacokinetics-from-in-vitro-properties-of-dry-powder-inhalers
#4
Sharvari Bhagwat, Uta Schilling, Mong-Jen Chen, Xiangyin Wei, Renishkumar Delvadia, Mohammad Absar, Bhawana Saluja, Günther Hochhaus
PURPOSE: The ability of two semi-mechanistic simulation approaches to predict the systemic pharmacokinetics (PK) of inhaled corticosteroids (ICSs) delivered via dry powder inhalers (DPIs) was assessed for mometasone furoate, budesonide and fluticasone propionate. METHODS: Both approaches derived the total lung doses and the central to peripheral lung deposition ratios from clinically relevant cascade impactor studies, but differed in the way the pulmonary absorption rate was derived...
August 10, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28753097/mometasone-furoate-in-the-treatment-of-vulvar-lichen-sclerosus-could-its-formulation-influence-efficacy-tolerability-and-adherence-to-treatment
#5
Monica Corazza, Annarosa Virgili, Giulia Toni, Alessandro Borghi
Purpose To assess the effectiveness, tolerability and convenience of the cream formulation of mometasone furoate 0.1% (MMF) in the treatment of active vulvar lichen sclerosus (VLS) and to compare the cream with the ointment formulation. Methods The following efficacy parameters were assessed in 27 VLS patients treated with MMF cream for 12 weeks (group A): i) response rate, ii) percentage of patients achieving an improvement from baseline of ≥75% in subjective and objective scores, iii) mean reduction in subjective and objective scores...
July 28, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28737966/effect-of-obesity-on-sinonasal-disease-in-asthma
#6
S Kanagalingam, S S Shehab, D A Kaminsky, R A Wise, J E Lang, A E Dixon
Sinonasal disease can contribute to poor asthma control. There are reports that link obesity with an increased prevalence of sinonasal disease, but no studies evaluating the severity of sinonasal disease in obese asthmatics, and how this impacts asthma control. The purpose of the current study was to determine if obesity is associated with increased severity of sinonasal disease, and/or affects response to nasal corticosteroid treatment in asthma. METHODS: This study included 236 adults participating in a 24-week randomized, double-masked, placebo-controlled study of nasal mometasone for the treatment of poorly controlled asthma...
July 24, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28714745/long-term-use-of-inhaled-corticosteroids-and-risk-of-upper-respiratory-tract-infection-in-chronic-obstructive-pulmonary-disease-a-meta-analysis
#7
Mingjin Yang, Hong Chen, Yan Zhang, Yuejun Du, Ying Xu, Ping Jiang, Zhibo Xu
Recent studies have suggested that inhaled corticosteroids (ICS) may be associated with higher risks of tuberculosis and pneumonia in patients with COPD. However, it is not known whether ICS increases the risk of upper respiratory tract infection (URTI). Aim of this study was to explore the relationship between ICS and URTI. Through a comprehensive literature search of PubMed, EMBASE, Cochrane Library, and Google Scholar from inception to March 2016, we identified randomized controlled trials of ICS therapy lasting at least 6 months...
April 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/28707716/paraneoplastic-systemic-lupus-erythematosus-in-association-with-oat-cell-tumour-of-the-lung
#8
Yora Mostmans, Martine Grosber, Arlette De Coninck, Johannes Ring, Jan Gutermuth
A 63-year-old man presented in the emergency department with general malaise, asthenia, an erythematosquamous rash on face and forearms and severe hyponatremia. The rash appeared after working in his garden on a sunny afternoon without sunscreen protection (Figure 1A/B/C). Furosemide was stopped and once daily mometason furoate cream was prescribed. Hyponatremia was corrected by IV hypertonic fluids. Five days later, the rash spread to the upper legs, chest and back. Histopathology revealed damage of the basal layer with necrotic keratinocytes and dermal perivascular and adnexal infiltrates (Figure 2)...
July 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28677353/individualized-treatment-of-allergic-rhinitis-according-to-nasal-cytology
#9
Jianjun Chen, Yue Zhou, Li Zhang, Yanjun Wang, Amber N Pepper, Seong H Cho, Weijia Kong
PURPOSE: Nasal cytology is important in the diagnosis and treatment of nasal inflammatory diseases. Treatment of allergic rhinitis (AR) according to nasal cytology has not been fully studied. We plan to explore the individualized treatment of AR according to nasal cytology. METHODS: Nasal cytology from 468 AR patients was examined for inflammatory cell quantity (grade 0-5) and the percentage of neutrophils and eosinophils. Results were subdivided into the following categories: AR(Eos), eosinophil ≥50% of the whole inflammatory cells; AR(Neu), neutrophils ≥90%; AR(Eos/Neu), 10%≤ eosinophil <50%; AR(Low), grade 0/1 inflammatory cell quantity...
September 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28652903/complete-clearance-of-resistant-granuloma-faciale-with-pulsed-dye-laser-after-pre-treatment-with-mometasone-and-tacrolimus
#10
Daniel Micallef, Michael J Boffa
Introduction: Granuloma faciale is an uncommon inflammatory dermatosis which usually affects the face and is often resistant to treatment. Case Report: A 39-year-old English lady with Fitzpatrick skin phototype II presented with typical lesions of granuloma faciale, confirmed on biopsy, on her cheeks and nose. Treatment with ScleroPlus pulsed dye laser (Candela Corporation, Wayland, Mass) produced no visible improvement. The patient re-presented 5 years later with the same lesions, now more prominent. No improvement was noted with topical mometasone, however addition of topical tacrolimus caused significant flattening...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/28543851/guttate-psoriasis-triggered-by-perianal-streptococcal-infection
#11
F M Garritsen, D E Kraag, M de Graaf
The association of guttate psoriasis (GP) with streptococcal pharyngitis is well accepted. However, less is known about the association with perianal streptococcal infection. We report a case of a 19-month-old boy with GP after a preceding perianal streptococcal dermatitis, with no clinical signs of a streptococcal pharyngitis. Treatment with phenethicillin was given together with mometasone ointment. After 4 weeks, the perianal redness was reduced and the psoriasis had improved significantly. A review of the literature revealed nine previous case reports, comprising a total of 15 patients...
May 22, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28514369/-the-role-of-topical-glucocorticoids-in-the-treatment-of-rhinosinusitis
#12
E G Shakhova
The guidelines of the European position paper on rhinosinusitis and nasal polyps (EPOS, 2012) ascribe the highest strength and the most comprehensive evidence-based significance to the application of intranasal glucocorticosteroids (inGCS) as the first-line therapy for the patients presenting with acute and polypous rhinosinusitis; moreover they are recommended as the medications of choice for the treatment of chronic rhinosinusitis in the absence of polyps. The author presents the data concerning the mechanism of action, clinical effectiveness, and safety of inGCS used for the treatment of acute, recurrent, and chronic rhinosinusitis...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28514368/-the-use-of-modern-topical-medications-for-the-stepwise-treatment-of-allergic-rhinitis-the-effectiveness-and-prospects-for-the-further-extension-of-their-application
#13
REVIEW
E V Nosulya, I A Kim
The objective of the present work was to summarize the results of clinical studies designed to evaluate the effectiveness of 'Momate Rhino Advance' in the form of the nasal spray (based on the fixed combination of mometasone furoate and azelastine) that finds an increasingly wide application for the treatment of allergic rhinitis. The available data give evidence that this medication can be prescribed to the patients presenting with the severe and moderate form of allergic rhinitis. The treatment should be started with the use of the combined preparation and continued, after the adequate control of the clinical symptoms of allergic rhinitis is achieved, using 'Momate Rhino' during the next 2-4 weeks for the reliable management of the disease...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28493194/effectiveness-of-quercetin-in-an-experimental-rat-model-of-allergic-rhinitis
#14
Mustafa Sagit, Halil Polat, Seren Gulsen Gurgen, Elife Berk, Sabri Guler, Mehmet Yasar
We aimed to investigate whether quercetin had a therapeutic effect in an experimental rat model of allergic rhinitis. The study was conducted with 35 rats, which were randomly assigned into 4 groups: group 1 (n = 5), sham group; group 2 (quercetin group, n = 10) received 80 mg/kg day quercetin; group 3 (steroid group, n = 10) received steroid (mometasone furoate); and group 4 (control group, n = 10), received ovalbumin alone. Rats were sensitized by administration of ovalbumin on alternate days over 14 days via an intraperitoneal route...
August 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28492586/-risk-of-pneumonia-during-long-term-regular-treatment-of-stable-copd-with-inhaled-glucocorticoids-a-systematic-review
#15
Fabio Arpinelli, Gaetano Caramori, Maria Sandra Magnoni
Inhaled glucocorticoids are anti-inflammatory drugs used in combination with long acting bronchodilators beta2-agonists for the treatment of stable chronic obstructive pulmonary disease (COPD), to improve lung function and symptoms and to reduce the future risk COPD exacerbations. However, has been also associated to an increased risk of pneumonia. The objective of this systematic review was therefore to analyze all randomized controlled trials to identify the risk of pneumonia during the regular treatment with long-term inhaled glucocorticosteroids compared to treatment with placebo in patients with stable COPD...
April 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28491450/contribution-of-oral-triamcinolone-to-treating-proliferative-and-necrotising-otitis-externa-in-a-14-year-old-persian-cat
#16
Yutaka Momota, Junya Yasuda, Nobuaki Arai, Masami Yamamoto, Hisashi Yoshimura, Mitsutaka Ikezawa, Shuji Suzuki, Kimimasa Takahashi, Toshinori Sako
CASE SUMMARY: A 14-year-old female spayed cat was referred for recurrent otitis externa and unusual proliferative lesions in both ear canals. The affected pinnae and external ear canals were covered with large reddish-to-dark-brown verrucous and necrotic tissue. Friable material and exudates occluded both ear canals. Proliferative lesions developed in both ears 2-3 weeks before referral. The histopathological diagnosis from two biopsies obtained from the friable materials with endoscopic biopsy forceps was proliferative and necrotising otitis externa (PNOE)...
January 2017: JFMS open reports
https://www.readbyqxmd.com/read/28489737/clinical-effect-of-montelukast-sodium-combined-with-inhaled-corticosteroids-in-the-treatment-of-osas-children
#17
Da-Zhi Yang, Jia Liang, Feng Zhang, Hong-Bing Yao, Yan Shu
This study was designed to investigate the clinical effect of montelukast sodium combined with inhaled corticosteroids in the treatment of children with obstructive sleep apnea syndrome (OSAS).One hundred ninety-five children were enrolled and divided into 3 groups: groups A, B, and C; the group A (oral use of montelukast sodium), group B (nasal spray of mometasone furoate), and group C (oral use of montelukast sodium + nasal spray of mometasone furoate). Telephone questionnaire surveys were carried out. Polysomnography monitoring was performed and lateral x-ray radiographs of the cervical spine were taken before treatment and at 12 weeks after treatment...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28482207/evaluation-of-graphical-and-statistical-representation-of-analytical-signals-of-spectrophotometric-methods
#18
Hayam Mahmoud Lotfy, Yasmin Mohammed Fayez, Shereen Mostafa Tawakkol, Nesma Mahmoud Fahmy, Mostafa Abd El-Atty Shehata
Simultaneous determination of miconazole (MIC), mometasone furaoate (MF), and gentamicin (GEN) in their pharmaceutical combination. Gentamicin determination is based on derivatization with of o-phthalaldehyde reagent (OPA) without any interference of other cited drugs, while the spectra of MIC and MF are resolved using both successive and progressive resolution techniques. The first derivative spectrum of MF is measured using constant multiplication or spectrum subtraction, while its recovered zero order spectrum is obtained using derivative transformation...
April 20, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28421984/stability-indicating-uplc-method-for-the-estimation-of-nadifloxacin-terbinafine-hydrochloride-mometasone-furoate-methyl-paraben-and-propyl-paraben-in-topical-pharmaceutical-dosage-form
#19
Dileep M Bhosale, Anna Pratima G Nikalje
A novel and simple ultra-performance LC method was developed for the estimation of nadifloxacin (NAD), terbinafine hydrochloride (TBH), mometasone furoate (MMF), methyl paraben (MP), and propyl paraben (PP) in a topical pharmaceutical dosage formulation. The analysis was carried out on a Waters Acquity UPLC ethylene bridged hybrid C18 column (50 × 2.1 mm, 1.7 μm) with a flow rate of 0.4 mL/min in gradient mode at a wavelength of 255 nm. Elution of all components was achieved within 9 min. The retention times of MP, NAD, PP, TBH, and MMF were observed at 1...
April 18, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28401798/most-frequently-reported-prescription-medications-and-supplements-in-couples-planning-pregnancy-the-life-study
#20
Kristin Palmsten, Katrina F Flores, Christina D Chambers, Lauren A Weiss, Rajeshwari Sundaram, Germaine M Buck Louis
OBJECTIVE: To identify frequently reported prescription medications and supplements among couples planning pregnancy because there is a lack of descriptive information on these agents in women and men who are trying to conceive. METHODS: Five hundred one couples enrolled in the Longitudinal Study of Infertility and the Environment, which took place between 2005 and 2009. Participants reported prescription medications as well as prescription and over-the-counter supplements used through interviews at study enrollment and through daily dairies during the 12-month follow-up...
January 1, 2017: Reproductive Sciences
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