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https://read.qxmd.com/read/18041087/primary-central-nervous-system-vasculitis-progress-and-questions
#21
EDITORIAL
Leonard H Calabrese, Eamonn S Molloy, Aneesh B Singhal
No abstract text is available yet for this article.
November 2007: Annals of Neurology
https://read.qxmd.com/read/17445624/benign-angiopathy-of-the-central-nervous-system-presenting-with-intracerebral-hemorrhage
#22
JOURNAL ARTICLE
Shaye I Moskowitz, Leonard H Calabrese, Robert J Weil
BACKGROUND: Primary central nervous system vasculitis has traditionally been described as an aggressive condition, with significant morbidity and mortality. A subgroup of patients has been identified who have a similar clinical presentation, but with a benign course. This syndrome of BACNS is successfully treated with low-dose steroids and calcium-channel blockers. Histologic confirmation, when performed, is normal. METHODS: Intracerebral hemorrhage is a rare presenting finding in the setting of BACNS...
May 2007: Surgical Neurology
https://read.qxmd.com/read/17092443/central-nervous-system-vasculitis-in-children
#23
REVIEW
Susanne M Benseler
Central nervous system (CNS) vasculitis is an increasingly recognized, often devastating inflammatory brain disease of children and adults. In primary or isolated CNS vasculitis/angiitis of childhood (cPACNS), the vascular inflammation is limited to the brain and spinal cord. Secondary CNS vasculitis occurs in a variety of conditions including infections, collagen vascular diseases, systemic vasculidities, and malignancies. Mimics of CNS vasculitis in children include dissections and noninflammatory vasculopathies...
December 2006: Current Rheumatology Reports
https://read.qxmd.com/read/15675139/branch-retinal-artery-occlusions-as-the-presenting-feature-of-primary-central-nervous-system-vasculitis
#24
JOURNAL ARTICLE
J O Susac, L H Calabrese, E Baylin, R A Prayson, N E Medeiros, R P Hull, J P Tucker
A 39-year-old woman presented with multiple branch retinal artery occlusions almost three years before developing a mass lesion containing calcium in the left frontal lobe. Brain biopsy revealed a small vessel vasculitis and ischemic necrosis of brain with dystrophic calcification. We believe this to be the first case of primary CNS vasculitis with branch retinal artery occlusions and brain calcification.
2004: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/14740441/a-headache-and-a-mass-lesion-vasculitis-or-cns-sarcoid
#25
JOURNAL ARTICLE
L H Calabrese
No abstract text is available yet for this article.
November 2003: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/14740440/clinical-management-issues-in-vasculitis-angiographically-defined-angiitis-of-the-central-nervous-system-diagnostic-and-therapeutic-dilemmas
#26
JOURNAL ARTICLE
L H Calabrese
A case of acute neurologic deficit accompanied by a cerebral angiogram consistent with CNS vasculitis is presented. The differential diagnosis and diagnostic decision process generated in this type of evaluation is illustrated.
November 2003: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/12522842/benign-angiopathy-of-the-central-nervous-system-cohort-of-16-patients-with-clinical-course-and-long-term-followup
#27
JOURNAL ARTICLE
Rula A Hajj-Ali, Anthony Furlan, Alex Abou-Chebel, Leonard H Calabrese
OBJECTIVE: Benign angiopathy of the central nervous system (BACNS) is a subset of primary angiitis of the central nervous system (PACNS) with favorable outcome, not requiring prolonged immunosuppression. We retrospectively studied the clinical characteristics and prospectively assessed long-term outcome in a cohort of BACNS patients. METHODS: Patients meeting the clinical description for BACNS, evaluated and treated by a single investigator, were included. Data on demographics, signs and symptoms, laboratory studies, neuroimaging, brain biopsy, treatment, and complications were recorded...
December 15, 2002: Arthritis and Rheumatism
https://read.qxmd.com/read/12418446/central-nervous-system-vasculitis-in-the-intensive-care-unit
#28
REVIEW
Rula A Hajj-Ali, Shekhar Ghamande, Leonard H Calabrese, Alejandro C Arroliga
Intensivists are sometimes faced with unexplained neurologic defects in ICU patients. A subacute presentation over weeks or months characterized by headache and mental status change with focal deficits in the absence of evidence of secondary vasculitis or other diseases mentioned in the differential diagnosis should arouse suspicion of PACNS. Delay in diagnosis of this rare condition may lead to additional morbidity and prolong ICU stay. There is also a risk of permanent cognitive dysfunction with untreated PACNS...
October 2002: Critical Care Clinics
https://read.qxmd.com/read/12086248/diagnostic-strategies-in-vasculitis-affecting-the-central-nervous-system
#29
REVIEW
Leonard H Calabrese
No abstract text is available yet for this article.
2002: Cleveland Clinic Journal of Medicine
https://read.qxmd.com/read/8867537/drug-induced-vasculitis
#30
REVIEW
L H Calabrese, G F Duna
Vasculitis resulting from drug use includes a wide variety of clinical and pathologic conditions that are, in general, empirically defined and poorly understood. Further complicating our grasp of these disorders are ambiguous terms such as hypersensitivity vasculitis, allergic vasculitis, leukocytoclastic vasculitis, serum sickness, and others, which are often used interchangeably without clear definition. The clinical picture varies widely from self-limiting to progressive and even fatal illness. These syndromes have now been reported in association with newer classes of therapeutic agents including biologic response modifiers...
January 1996: Current Opinion in Rheumatology
https://read.qxmd.com/read/8592737/vasculitis-of-the-central-nervous-system
#31
REVIEW
L H Calabrese
Angiitis of the CNS remains a poorly understood form of vascular inflammatory disease. Primary angiitis of the CNS or PACNS, a disease once considered extremely rare, recently has been reported more frequently. Traditional views of PACNS held it to be a relentless and uniformly fatal disease if untreated, but it is now viewed as more heterogeneous, with some relatively benign subsets. Its pathophysiology is poorly understood. Secondary vasculitis of the CNS can occur with a variety of other conditions and diseases; each requires a different diagnostic and therapeutic approach...
November 1995: Rheumatic Diseases Clinics of North America
https://read.qxmd.com/read/8014931/benign-angiopathy-a-distinct-subset-of-angiographically-defined-primary-angiitis-of-the-central-nervous-system
#32
COMPARATIVE STUDY
L H Calabrese, L A Gragg, A J Furlan
OBJECTIVE: Primary angiitis of the central nervous system (PACNS) has been considered a rare and highly fatal disorder when untreated. In recent years the disease has been increasingly diagnosed by cerebral angiography, often without histologic confirmation. We have questioned whether cases of PACNS diagnosed on the basis of angiography alone are equivalent to histologically confirmed cases. METHODS: All cases of PACNS reported from 2 sources, including all cases reported in the English medical literature through January of 1990 as well as from the case records of the Cleveland Clinic Foundation were reviewed...
December 1993: Journal of Rheumatology
https://read.qxmd.com/read/7791160/limitations-of-invasive-modalities-in-the-diagnosis-of-primary-angiitis-of-the-central-nervous-system
#33
JOURNAL ARTICLE
G F Duna, L H Calabrese
OBJECTIVE: Rheumatologists are often consulted to evaluate patients suspected of having primary angiitis of the central nervous system (PACNS). The diagnostic process relies heavily on interpreting the results of cerebral angiography and brain biopsy. We have assessed the operating characteristics of those invasive modalities in the diagnosis of PACNS: METHODS: The records of 30 consecutive patients referred for the evaluation of possible PACNS were retrospectively analyzed...
April 1995: Journal of Rheumatology
https://read.qxmd.com/read/7718420/evaluation-and-treatment-of-central-nervous-system-vasculitis
#34
REVIEW
L H Calabrese, G F Duna
Angiitis of the central nervous system (CNS) remains a poorly understood and clinically challenging form of vascular inflammatory disease. Primary angiitis of the CNS (PACNS) has been viewed as a relentless and uniformly fatal disorder if untreated. In addition, recent trends have demonstrated an increasing reliance on angiographic diagnosis without tissue confirmation. It has been suggested that PACNS is clinically more heterogeneous than previously appreciated and may include relatively benign subsets. A reappraisal of diagnostic approaches has suggested caution in the diagnosis of CNS angiitis on purely angiographic grounds...
January 1995: Current Opinion in Rheumatology
https://read.qxmd.com/read/2920056/central-nervous-system-vasculitis-in-beh%C3%A3-et-s-syndrome-angiographic-improvement-after-therapy-with-cytotoxic-agents
#35
JOURNAL ARTICLE
J D Zelenski, J A Capraro, D Holden, L H Calabrese
We describe a patient with Behçet's syndrome who had clinical and angiographic features of widespread cerebral angiitis of small- and medium-caliber vessels. We report the successful treatment of this condition with a combination of cytotoxic agents and steroids, and demonstrate angiographically the resolution of these abnormalities in neuro-Behçet's disease.
February 1989: Arthritis and Rheumatism
https://read.qxmd.com/read/2041883/vasculitis-and-infection-with-the-human-immunodeficiency-virus
#36
REVIEW
L H Calabrese
Vasculitic syndromes associated with infection with the human immunodeficiency virus (HIV) would appear to represent a microcosm of the vasculitic spectrum. Reported cases have included polyarteritis nodosa-like illnesses, hypersensitivity vasculitis, lymphomatoid granulomatosis, primary angiitis of the central nervous system, and a number of miscellaneous disorders. The pathogenesis of these conditions is unclear, but some appear to be mediated in part by the HIV itself. Therapeutically, little clinical data exist to guide clinicians in the management of such patients, but aggressive approaches combining immunosuppressive therapy with assertive antimicrobial prophylaxis may be warranted...
February 1991: Rheumatic Diseases Clinics of North America
https://read.qxmd.com/read/1516217/primary-angiitis-of-the-central-nervous-system-diagnostic-criteria-and-clinical-approach
#37
REVIEW
L H Calabrese, A J Furlan, L A Gragg, T J Ropos
Primary angiitis of the central nervous system has until recently been considered rare, usually progressive, and untreatable. In 1987, preliminary diagnostic criteria for the disorder were proposed in the hope of gaining a more accurate description of the disease. We used these criteria in reviewing all cases reported in the English language (99 cases) and those seen at The Cleveland Clinic Foundation (9 cases). We believe that the disorder is heterogeneous, and has a better prognosis than previously thought...
May 1992: Cleveland Clinic Journal of Medicine
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