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JOURNAL ARTICLE
Jaume Guia, Tazim Jamal
Posthumanistic inquiry is young and offers new ways to understand critical and ethical relationships, bringing new axiological perspectives to current debates around travel, mobilities and (post)modernist conceptualizations of tourism. This research note introduces a Deleuzian posthumanism paradigm with ontological, epistemological and methodological directions to approach tourism research from a non-dualist perspective. French philosopher Gilles Deleuze offers a postdualist, process-oriented ontology of difference that is vital to create radical new tourism knowledge, and avoid indefensible 'either-or' binaries in research and praxis...
September 2020: Annals of tourism research
#22
JOURNAL ARTICLE
Jonathan R S McIntyre, Candace Burton, Dave Holmes
The everyday expressions of nursing practices are driven by their entanglement in complex flows of social, cultural, political and economic interests. Early expressions of trained nursing practice in the United States and Europe reflect claims of moral, spiritual and clinical exceptionalism. They were both imposed upon-and internalized by-nursing pioneers. These claims were associated with an endogenous narrative of discipline and its physical manifestation in early nursing schools and hospitals, which functioned as "total institutions...
July 27, 2020: Nursing Philosophy: An International Journal for Healthcare Professionals
#23
JOURNAL ARTICLE
Tim Barlott, Lynda Shevellar, Merrill Turpin, Jenny Setchell
People who have been diagnosed with serious mental illness have a long history of confinement, social stigma and marginalisation that has constrained their participation in society. Drawing upon the work of Gilles Deleuze and Felix Guattari, we have used the concepts of: assemblages, major and minor and deterritorialisation to critically analyse two pervasive and 'taken-for-granted' assemblages in mental health: recovery (including clinical recovery, social recovery and recovery-oriented practice) and social inclusion...
June 11, 2020: Sociology of Health & Illness
#24
JOURNAL ARTICLE
George B Hogenson
The paper reviews the course of the controversy surrounding Jung's theory of archetypes beginning in the mid 1990s and continuing to the present. Much of this controversy was concerned with the debate between the essentialism of the evolutionary position of Anthony Stevens as found in his 1983 book Archetypes: A Natural History of the Self, and the emergence model of the archetypes proposed in various publications by Hogenson, Knox and Merchant, among others. The paper then moves on to a consideration of more recent developments in theory, particularly as derived from an examination of the philosopher Gilles Deleuze, who introduces Bergson's somnambulistic unconscious into the discussion of Jung's theories...
November 2019: Journal of Analytical Psychology
#25
JOURNAL ARTICLE
Nicolas O Fortunel, Loubna Chadli, Julien Coutier, Gilles Lemaître, Frédéric Auvré, Sophie Domingues, Emmanuelle Bouissou-Cadio, Pierre Vaigot, Sophie Cavallero, Jean-François Deleuze, Paul-Henri Roméo, Michèle T Martin
Expanded autologous skin keratinocytes are currently used in cutaneous cell therapy, and embryonic-stem-cell-derived keratinocytes could become a complementary alternative. Regardless of keratinocyte provenance, for efficient therapy it is necessary to preserve immature keratinocyte precursors during cell expansion and graft processing. Here, we show that stable and transient downregulation of the transcription factor Krüppel-like factor 4 (KLF4) in keratinocyte precursors from adult skin, using anti-KLF4 RNA interference or kenpaullone, promotes keratinocyte immaturity and keratinocyte self-renewal in vitro, and enhances the capacity for epidermal regeneration in mice...
December 2019: Nature Biomedical Engineering
#26
Brian W Kunkle, Benjamin Grenier-Boley, Rebecca Sims, Joshua C Bis, Vincent Damotte, Adam C Naj, Anne Boland, Maria Vronskaya, Sven J van der Lee, Alexandre Amlie-Wolf, Céline Bellenguez, Aura Frizatti, Vincent Chouraki, Eden R Martin, Kristel Sleegers, Nandini Badarinarayan, Johanna Jakobsdottir, Kara L Hamilton-Nelson, Sonia Moreno-Grau, Robert Olaso, Rachel Raybould, Yuning Chen, Amanda B Kuzma, Mikko Hiltunen, Taniesha Morgan, Shahzad Ahmad, Badri N Vardarajan, Jacques Epelbaum, Per Hoffmann, Merce Boada, Gary W Beecham, Jean-Guillaume Garnier, Denise Harold, Annette L Fitzpatrick, Otto Valladares, Marie-Laure Moutet, Amy Gerrish, Albert V Smith, Liming Qu, Delphine Bacq, Nicola Denning, Xueqiu Jian, Yi Zhao, Maria Del Zompo, Nick C Fox, Seung-Hoan Choi, Ignacio Mateo, Joseph T Hughes, Hieab H Adams, John Malamon, Florentino Sanchez-Garcia, Yogen Patel, Jennifer A Brody, Beth A Dombroski, Maria Candida Deniz Naranjo, Makrina Daniilidou, Gudny Eiriksdottir, Shubhabrata Mukherjee, David Wallon, James Uphill, Thor Aspelund, Laura B Cantwell, Fabienne Garzia, Daniela Galimberti, Edith Hofer, Mariusz Butkiewicz, Bertrand Fin, Elio Scarpini, Chloe Sarnowski, Will S Bush, Stéphane Meslage, Johannes Kornhuber, Charles C White, Yuenjoo Song, Robert C Barber, Sebastiaan Engelborghs, Sabrina Sordon, Dina Voijnovic, Perrie M Adams, Rik Vandenberghe, Manuel Mayhaus, L Adrienne Cupples, Marilyn S Albert, Peter P De Deyn, Wei Gu, Jayanadra J Himali, Duane Beekly, Alessio Squassina, Annette M Hartmann, Adelina Orellana, Deborah Blacker, Eloy Rodriguez-Rodriguez, Simon Lovestone, Melissa E Garcia, Rachelle S Doody, Carmen Munoz-Fernadez, Rebecca Sussams, Honghuang Lin, Thomas J Fairchild, Yolanda A Benito, Clive Holmes, Hata Karamujić-Čomić, Matthew P Frosch, Hakan Thonberg, Wolfgang Maier, Gennady Roshchupkin, Bernardino Ghetti, Vilmantas Giedraitis, Amit Kawalia, Shuo Li, Ryan M Huebinger, Lena Kilander, Susanne Moebus, Isabel Hernández, M Ilyas Kamboh, RoseMarie Brundin, James Turton, Qiong Yang, Mindy J Katz, Letizia Concari, Jenny Lord, Alexa S Beiser, C Dirk Keene, Seppo Helisalmi, Iwona Kloszewska, Walter A Kukull, Anne Maria Koivisto, Aoibhinn Lynch, Lluís Tarraga, Eric B Larson, Annakaisa Haapasalo, Brian Lawlor, Thomas H Mosley, Richard B Lipton, Vincenzo Solfrizzi, Michael Gill, W T Longstreth, Thomas J Montine, Vincenza Frisardi, Monica Diez-Fairen, Fernando Rivadeneira, Ronald C Petersen, Vincent Deramecourt, Ignacio Alvarez, Francesca Salani, Antonio Ciaramella, Eric Boerwinkle, Eric M Reiman, Nathalie Fievet, Jerome I Rotter, Joan S Reisch, Olivier Hanon, Chiara Cupidi, A G Andre Uitterlinden, Donald R Royall, Carole Dufouil, Raffaele Giovanni Maletta, Itziar de Rojas, Mary Sano, Alexis Brice, Roberta Cecchetti, Peter St George-Hyslop, Karen Ritchie, Magda Tsolaki, Debby W Tsuang, Bruno Dubois, David Craig, Chuang-Kuo Wu, Hilkka Soininen, Despoina Avramidou, Roger L Albin, Laura Fratiglioni, Antonia Germanou, Liana G Apostolova, Lina Keller, Maria Koutroumani, Steven E Arnold, Francesco Panza, Olymbia Gkatzima, Sanjay Asthana, Didier Hannequin, Patrice Whitehead, Craig S Atwood, Paolo Caffarra, Harald Hampel, Inés Quintela, Ángel Carracedo, Lars Lannfelt, David C Rubinsztein, Lisa L Barnes, Florence Pasquier, Lutz Frölich, Sandra Barral, Bernadette McGuinness, Thomas G Beach, Janet A Johnston, James T Becker, Peter Passmore, Eileen H Bigio, Jonathan M Schott, Thomas D Bird, Jason D Warren, Bradley F Boeve, Michelle K Lupton, James D Bowen, Petra Proitsi, Adam Boxer, John F Powell, James R Burke, John S K Kauwe, Jeffrey M Burns, Michelangelo Mancuso, Joseph D Buxbaum, Ubaldo Bonuccelli, Nigel J Cairns, Andrew McQuillin, Chuanhai Cao, Gill Livingston, Chris S Carlson, Nicholas J Bass, Cynthia M Carlsson, John Hardy, Regina M Carney, Jose Bras, Minerva M Carrasquillo, Rita Guerreiro, Mariet Allen, Helena C Chui, Elizabeth Fisher, Carlo Masullo, Elizabeth A Crocco, Charles DeCarli, Gina Bisceglio, Malcolm Dick, Li Ma, Ranjan Duara, Neill R Graff-Radford, Denis A Evans, Angela Hodges, Kelley M Faber, Martin Scherer, Kenneth B Fallon, Matthias Riemenschneider, David W Fardo, Reinhard Heun, Martin R Farlow, Heike Kölsch, Steven Ferris, Markus Leber, Tatiana M Foroud, Isabella Heuser, Douglas R Galasko, Ina Giegling, Marla Gearing, Michael Hüll, Daniel H Geschwind, John R Gilbert, John Morris, Robert C Green, Kevin Mayo, John H Growdon, Thomas Feulner, Ronald L Hamilton, Lindy E Harrell, Dmitriy Drichel, Lawrence S Honig, Thomas D Cushion, Matthew J Huentelman, Paul Hollingworth, Christine M Hulette, Bradley T Hyman, Rachel Marshall, Gail P Jarvik, Alun Meggy, Erin Abner, Georgina E Menzies, Lee-Way Jin, Ganna Leonenko, Luis M Real, Gyungah R Jun, Clinton T Baldwin, Detelina Grozeva, Anna Karydas, Giancarlo Russo, Jeffrey A Kaye, Ronald Kim, Frank Jessen, Neil W Kowall, Bruno Vellas, Joel H Kramer, Emma Vardy, Frank M LaFerla, Karl-Heinz Jöckel, James J Lah, Martin Dichgans, James B Leverenz, David Mann, Allan I Levey, Stuart Pickering-Brown, Andrew P Lieberman, Norman Klopp, Kathryn L Lunetta, H-Erich Wichmann, Constantine G Lyketsos, Kevin Morgan, Daniel C Marson, Kristelle Brown, Frank Martiniuk, Christopher Medway, Deborah C Mash, Markus M Nöthen, Eliezer Masliah, Nigel M Hooper, Wayne C McCormick, Antonio Daniele, Susan M McCurry, Anthony Bayer, Andrew N McDavid, John Gallacher, Ann C McKee, Hendrik van den Bussche, Marsel Mesulam, Carol Brayne, Bruce L Miller, Steffi Riedel-Heller, Carol A Miller, Joshua W Miller, Ammar Al-Chalabi, John C Morris, Christopher E Shaw, Amanda J Myers, Jens Wiltfang, Sid O'Bryant, John M Olichney, Victoria Alvarez, Joseph E Parisi, Andrew B Singleton, Henry L Paulson, John Collinge, William R Perry, Simon Mead, Elaine Peskind, David H Cribbs, Martin Rossor, Aimee Pierce, Natalie S Ryan, Wayne W Poon, Benedetta Nacmias, Huntington Potter, Sandro Sorbi, Joseph F Quinn, Eleonora Sacchinelli, Ashok Raj, Gianfranco Spalletta, Murray Raskind, Carlo Caltagirone, Paola Bossù, Maria Donata Orfei, Barry Reisberg, Robert Clarke, Christiane Reitz, A David Smith, John M Ringman, Donald Warden, Erik D Roberson, Gordon Wilcock, Ekaterina Rogaeva, Amalia Cecilia Bruni, Howard J Rosen, Maura Gallo, Roger N Rosenberg, Yoav Ben-Shlomo, Mark A Sager, Patrizia Mecocci, Andrew J Saykin, Pau Pastor, Michael L Cuccaro, Jeffery M Vance, Julie A Schneider, Lori S Schneider, Susan Slifer, William W Seeley, Amanda G Smith, Joshua A Sonnen, Salvatore Spina, Robert A Stern, Russell H Swerdlow, Mitchell Tang, Rudolph E Tanzi, John Q Trojanowski, Juan C Troncoso, Vivianna M Van Deerlin, Linda J Van Eldik, Harry V Vinters, Jean Paul Vonsattel, Sandra Weintraub, Kathleen A Welsh-Bohmer, Kirk C Wilhelmsen, Jennifer Williamson, Thomas S Wingo, Randall L Woltjer, Clinton B Wright, Chang-En Yu, Lei Yu, Yasaman Saba, Alberto Pilotto, Maria J Bullido, Oliver Peters, Paul K Crane, David Bennett, Paola Bosco, Eliecer Coto, Virginia Boccardi, Phil L De Jager, Alberto Lleo, Nick Warner, Oscar L Lopez, Martin Ingelsson, Panagiotis Deloukas, Carlos Cruchaga, Caroline Graff, Rhian Gwilliam, Myriam Fornage, Alison M Goate, Pascual Sanchez-Juan, Patrick G Kehoe, Najaf Amin, Nilifur Ertekin-Taner, Claudine Berr, Stéphanie Debette, Seth Love, Lenore J Launer, Steven G Younkin, Jean-Francois Dartigues, Chris Corcoran, M Arfan Ikram, Dennis W Dickson, Gael Nicolas, Dominique Campion, JoAnn Tschanz, Helena Schmidt, Hakon Hakonarson, Jordi Clarimon, Ron Munger, Reinhold Schmidt, Lindsay A Farrer, Christine Van Broeckhoven, Michael C O'Donovan, Anita L DeStefano, Lesley Jones, Jonathan L Haines, Jean-Francois Deleuze, Michael J Owen, Vilmundur Gudnason, Richard Mayeux, Valentina Escott-Price, Bruce M Psaty, Alfredo Ramirez, Li-San Wang, Agustin Ruiz, Cornelia M van Duijn, Peter A Holmans, Sudha Seshadri, Julie Williams, Phillippe Amouyel, Gerard D Schellenberg, Jean-Charles Lambert, Margaret A Pericak-Vance
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
September 2019: Nature Genetics
#27
JOURNAL ARTICLE
Eluana Borges Leitão de Figueiredo, Eliane Oliveira de Andrade, Marcela Pimenta Muniz, Ana Lúcia Abrahão
OBJECTIVE: to discuss search-interference, whose processes are related to the field of health and the social field. METHOD: theoretical essay used as basis in the philosophy of difference represented by the philosophers Baruch Espinosa and Gilles Deleuze. RESULTS: the present reflection resulted from the meeting of studies from the nursing field that deal with the production of knowledge based on the interference mode. The endeavor of crossing studies produced a theoretical composition presented in three plateaus: interference, a research that welcomes the In-World Experiences; a way of producing researchers; and a nomad mode in health research...
March 2019: Revista Brasileira de Enfermagem
#28
JOURNAL ARTICLE
Brian W Kunkle, Benjamin Grenier-Boley, Rebecca Sims, Joshua C Bis, Vincent Damotte, Adam C Naj, Anne Boland, Maria Vronskaya, Sven J van der Lee, Alexandre Amlie-Wolf, Céline Bellenguez, Aura Frizatti, Vincent Chouraki, Eden R Martin, Kristel Sleegers, Nandini Badarinarayan, Johanna Jakobsdottir, Kara L Hamilton-Nelson, Sonia Moreno-Grau, Robert Olaso, Rachel Raybould, Yuning Chen, Amanda B Kuzma, Mikko Hiltunen, Taniesha Morgan, Shahzad Ahmad, Badri N Vardarajan, Jacques Epelbaum, Per Hoffmann, Merce Boada, Gary W Beecham, Jean-Guillaume Garnier, Denise Harold, Annette L Fitzpatrick, Otto Valladares, Marie-Laure Moutet, Amy Gerrish, Albert V Smith, Liming Qu, Delphine Bacq, Nicola Denning, Xueqiu Jian, Yi Zhao, Maria Del Zompo, Nick C Fox, Seung-Hoan Choi, Ignacio Mateo, Joseph T Hughes, Hieab H Adams, John Malamon, Florentino Sanchez-Garcia, Yogen Patel, Jennifer A Brody, Beth A Dombroski, Maria Candida Deniz Naranjo, Makrina Daniilidou, Gudny Eiriksdottir, Shubhabrata Mukherjee, David Wallon, James Uphill, Thor Aspelund, Laura B Cantwell, Fabienne Garzia, Daniela Galimberti, Edith Hofer, Mariusz Butkiewicz, Bertrand Fin, Elio Scarpini, Chloe Sarnowski, Will S Bush, Stéphane Meslage, Johannes Kornhuber, Charles C White, Yuenjoo Song, Robert C Barber, Sebastiaan Engelborghs, Sabrina Sordon, Dina Voijnovic, Perrie M Adams, Rik Vandenberghe, Manuel Mayhaus, L Adrienne Cupples, Marilyn S Albert, Peter P De Deyn, Wei Gu, Jayanadra J Himali, Duane Beekly, Alessio Squassina, Annette M Hartmann, Adelina Orellana, Deborah Blacker, Eloy Rodriguez-Rodriguez, Simon Lovestone, Melissa E Garcia, Rachelle S Doody, Carmen Munoz-Fernadez, Rebecca Sussams, Honghuang Lin, Thomas J Fairchild, Yolanda A Benito, Clive Holmes, Hata Karamujić-Čomić, Matthew P Frosch, Hakan Thonberg, Wolfgang Maier, Gennady Roshchupkin, Bernardino Ghetti, Vilmantas Giedraitis, Amit Kawalia, Shuo Li, Ryan M Huebinger, Lena Kilander, Susanne Moebus, Isabel Hernández, M Ilyas Kamboh, RoseMarie Brundin, James Turton, Qiong Yang, Mindy J Katz, Letizia Concari, Jenny Lord, Alexa S Beiser, C Dirk Keene, Seppo Helisalmi, Iwona Kloszewska, Walter A Kukull, Anne Maria Koivisto, Aoibhinn Lynch, Lluís Tarraga, Eric B Larson, Annakaisa Haapasalo, Brian Lawlor, Thomas H Mosley, Richard B Lipton, Vincenzo Solfrizzi, Michael Gill, W T Longstreth, Thomas J Montine, Vincenza Frisardi, Monica Diez-Fairen, Fernando Rivadeneira, Ronald C Petersen, Vincent Deramecourt, Ignacio Alvarez, Francesca Salani, Antonio Ciaramella, Eric Boerwinkle, Eric M Reiman, Nathalie Fievet, Jerome I Rotter, Joan S Reisch, Olivier Hanon, Chiara Cupidi, A G Andre Uitterlinden, Donald R Royall, Carole Dufouil, Raffaele Giovanni Maletta, Itziar de Rojas, Mary Sano, Alexis Brice, Roberta Cecchetti, Peter St George-Hyslop, Karen Ritchie, Magda Tsolaki, Debby W Tsuang, Bruno Dubois, David Craig, Chuang-Kuo Wu, Hilkka Soininen, Despoina Avramidou, Roger L Albin, Laura Fratiglioni, Antonia Germanou, Liana G Apostolova, Lina Keller, Maria Koutroumani, Steven E Arnold, Francesco Panza, Olymbia Gkatzima, Sanjay Asthana, Didier Hannequin, Patrice Whitehead, Craig S Atwood, Paolo Caffarra, Harald Hampel, Inés Quintela, Ángel Carracedo, Lars Lannfelt, David C Rubinsztein, Lisa L Barnes, Florence Pasquier, Lutz Frölich, Sandra Barral, Bernadette McGuinness, Thomas G Beach, Janet A Johnston, James T Becker, Peter Passmore, Eileen H Bigio, Jonathan M Schott, Thomas D Bird, Jason D Warren, Bradley F Boeve, Michelle K Lupton, James D Bowen, Petra Proitsi, Adam Boxer, John F Powell, James R Burke, John S K Kauwe, Jeffrey M Burns, Michelangelo Mancuso, Joseph D Buxbaum, Ubaldo Bonuccelli, Nigel J Cairns, Andrew McQuillin, Chuanhai Cao, Gill Livingston, Chris S Carlson, Nicholas J Bass, Cynthia M Carlsson, John Hardy, Regina M Carney, Jose Bras, Minerva M Carrasquillo, Rita Guerreiro, Mariet Allen, Helena C Chui, Elizabeth Fisher, Carlo Masullo, Elizabeth A Crocco, Charles DeCarli, Gina Bisceglio, Malcolm Dick, Li Ma, Ranjan Duara, Neill R Graff-Radford, Denis A Evans, Angela Hodges, Kelley M Faber, Martin Scherer, Kenneth B Fallon, Matthias Riemenschneider, David W Fardo, Reinhard Heun, Martin R Farlow, Heike Kölsch, Steven Ferris, Markus Leber, Tatiana M Foroud, Isabella Heuser, Douglas R Galasko, Ina Giegling, Marla Gearing, Michael Hüll, Daniel H Geschwind, John R Gilbert, John Morris, Robert C Green, Kevin Mayo, John H Growdon, Thomas Feulner, Ronald L Hamilton, Lindy E Harrell, Dmitriy Drichel, Lawrence S Honig, Thomas D Cushion, Matthew J Huentelman, Paul Hollingworth, Christine M Hulette, Bradley T Hyman, Rachel Marshall, Gail P Jarvik, Alun Meggy, Erin Abner, Georgina E Menzies, Lee-Way Jin, Ganna Leonenko, Luis M Real, Gyungah R Jun, Clinton T Baldwin, Detelina Grozeva, Anna Karydas, Giancarlo Russo, Jeffrey A Kaye, Ronald Kim, Frank Jessen, Neil W Kowall, Bruno Vellas, Joel H Kramer, Emma Vardy, Frank M LaFerla, Karl-Heinz Jöckel, James J Lah, Martin Dichgans, James B Leverenz, David Mann, Allan I Levey, Stuart Pickering-Brown, Andrew P Lieberman, Norman Klopp, Kathryn L Lunetta, H-Erich Wichmann, Constantine G Lyketsos, Kevin Morgan, Daniel C Marson, Kristelle Brown, Frank Martiniuk, Christopher Medway, Deborah C Mash, Markus M Nöthen, Eliezer Masliah, Nigel M Hooper, Wayne C McCormick, Antonio Daniele, Susan M McCurry, Anthony Bayer, Andrew N McDavid, John Gallacher, Ann C McKee, Hendrik van den Bussche, Marsel Mesulam, Carol Brayne, Bruce L Miller, Steffi Riedel-Heller, Carol A Miller, Joshua W Miller, Ammar Al-Chalabi, John C Morris, Christopher E Shaw, Amanda J Myers, Jens Wiltfang, Sid O'Bryant, John M Olichney, Victoria Alvarez, Joseph E Parisi, Andrew B Singleton, Henry L Paulson, John Collinge, William R Perry, Simon Mead, Elaine Peskind, David H Cribbs, Martin Rossor, Aimee Pierce, Natalie S Ryan, Wayne W Poon, Benedetta Nacmias, Huntington Potter, Sandro Sorbi, Joseph F Quinn, Eleonora Sacchinelli, Ashok Raj, Gianfranco Spalletta, Murray Raskind, Carlo Caltagirone, Paola Bossù, Maria Donata Orfei, Barry Reisberg, Robert Clarke, Christiane Reitz, A David Smith, John M Ringman, Donald Warden, Erik D Roberson, Gordon Wilcock, Ekaterina Rogaeva, Amalia Cecilia Bruni, Howard J Rosen, Maura Gallo, Roger N Rosenberg, Yoav Ben-Shlomo, Mark A Sager, Patrizia Mecocci, Andrew J Saykin, Pau Pastor, Michael L Cuccaro, Jeffery M Vance, Julie A Schneider, Lori S Schneider, Susan Slifer, William W Seeley, Amanda G Smith, Joshua A Sonnen, Salvatore Spina, Robert A Stern, Russell H Swerdlow, Mitchell Tang, Rudolph E Tanzi, John Q Trojanowski, Juan C Troncoso, Vivianna M Van Deerlin, Linda J Van Eldik, Harry V Vinters, Jean Paul Vonsattel, Sandra Weintraub, Kathleen A Welsh-Bohmer, Kirk C Wilhelmsen, Jennifer Williamson, Thomas S Wingo, Randall L Woltjer, Clinton B Wright, Chang-En Yu, Lei Yu, Yasaman Saba, Alberto Pilotto, Maria J Bullido, Oliver Peters, Paul K Crane, David Bennett, Paola Bosco, Eliecer Coto, Virginia Boccardi, Phil L De Jager, Alberto Lleo, Nick Warner, Oscar L Lopez, Martin Ingelsson, Panagiotis Deloukas, Carlos Cruchaga, Caroline Graff, Rhian Gwilliam, Myriam Fornage, Alison M Goate, Pascual Sanchez-Juan, Patrick G Kehoe, Najaf Amin, Nilifur Ertekin-Taner, Claudine Berr, Stéphanie Debette, Seth Love, Lenore J Launer, Steven G Younkin, Jean-Francois Dartigues, Chris Corcoran, M Arfan Ikram, Dennis W Dickson, Gael Nicolas, Dominique Campion, JoAnn Tschanz, Helena Schmidt, Hakon Hakonarson, Jordi Clarimon, Ron Munger, Reinhold Schmidt, Lindsay A Farrer, Christine Van Broeckhoven, Michael C O'Donovan, Anita L DeStefano, Lesley Jones, Jonathan L Haines, Jean-Francois Deleuze, Michael J Owen, Vilmundur Gudnason, Richard Mayeux, Valentina Escott-Price, Bruce M Psaty, Alfredo Ramirez, Li-San Wang, Agustin Ruiz, Cornelia M van Duijn, Peter A Holmans, Sudha Seshadri, Julie Williams, Phillippe Amouyel, Gerard D Schellenberg, Jean-Charles Lambert, Margaret A Pericak-Vance
Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed LOAD (94,437 individuals). We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (ADAM10, ACE) were identified in a recent genome-wide association (GWAS)-by-familial-proxy of Alzheimer's or dementia. Fine-mapping of the human leukocyte antigen (HLA) region confirms the neurological and immune-mediated disease haplotype HLA-DR15 as a risk factor for LOAD...
March 2019: Nature Genetics
#29
JOURNAL ARTICLE
Kelly Ceyzériat, Lucile Ben Haim, Audrey Denizot, Dylan Pommier, Marco Matos, Océane Guillemaud, Marie-Ange Palomares, Laurene Abjean, Fanny Petit, Pauline Gipchtein, Marie-Claude Gaillard, Martine Guillermier, Sueva Bernier, Mylène Gaudin, Gwenaëlle Aurégan, Charlène Joséphine, Nathalie Déchamps, Julien Veran, Valentin Langlais, Karine Cambon, Alexis P Bemelmans, Jan Baijer, Gilles Bonvento, Marc Dhenain, Jean-François Deleuze, Stéphane H R Oliet, Emmanuel Brouillet, Philippe Hantraye, Maria-Angeles Carrillo-de Sauvage, Robert Olaso, Aude Panatier, Carole Escartin
Astrocyte reactivity and neuroinflammation are hallmarks of CNS pathological conditions such as Alzheimer's disease. However, the specific role of reactive astrocytes is still debated. This controversy may stem from the fact that most strategies used to modulate astrocyte reactivity and explore its contribution to disease outcomes have only limited specificity. Moreover, reactive astrocytes are now emerging as heterogeneous cells and all types of astrocyte reactivity may not be controlled efficiently by such strategies...
October 16, 2018: Acta Neuropathologica Communications
#30
JOURNAL ARTICLE
Kasper Levin
What role does the aesthetics of bodily movement play in the understanding of attention among children diagnosed with attention-deficit/hyperactivity disorder (ADHD)? This article animates a phenomenological approach to attention and embodiment with a special focus on the relation between aesthetic or expressive bodily movement and behavioral awareness in children diagnosed with ADHD. However, beyond this it is argued that the aesthetic aspect of movement calls for an expansion of the phenomenological perspective...
March 2018: Integrative Psychological & Behavioral Science
#31
JOURNAL ARTICLE
Elsa Curtit, Xavier Pivot, Julie Henriques, Sophie Paget-Bailly, Pierre Fumoleau, Maria Rios, Hervé Bonnefoi, Thomas Bachelot, Patrick Soulié, Christelle Jouannaud, Hugues Bourgeois, Thierry Petit, Isabelle Tennevet, David Assouline, Marie-Christine Mathieu, Jean-Philippe Jacquin, Sandrine Lavau-Denes, Ariane Darut-Jouve, Jean-Marc Ferrero, Carole Tarpin, Christelle Lévy, Valérie Delecroix, Véronique Trillet-Lenoir, Oana Cojocarasu, Jérôme Meunier, Jean-Yves Pierga, Pierre Kerbrat, Céline Faure-Mercier, Hélène Blanché, Mourad Sahbatou, Anne Boland, Delphine Bacq, Céline Besse, Gilles Thomas, Jean-François Deleuze, Iris Pauporté, Gilles Romieu, David G Cox
BACKGROUND: Genome-wide association studies (GWAS) have to date identified 94 genetic variants (single nucleotide polymorphisms (SNPs)) associated with risk of developing breast cancer. A score based on the combined effect of the 94 risk alleles can be calculated to measure the global risk of breast cancer. We aimed to test the hypothesis that the 94-SNP-based risk score is associated with clinico-pathological characteristics, breast cancer subtypes and outcomes in early breast cancer...
August 22, 2017: Breast Cancer Research: BCR
#32
JOURNAL ARTICLE
Rebecca Sims, Sven J van der Lee, Adam C Naj, Céline Bellenguez, Nandini Badarinarayan, Johanna Jakobsdottir, Brian W Kunkle, Anne Boland, Rachel Raybould, Joshua C Bis, Eden R Martin, Benjamin Grenier-Boley, Stefanie Heilmann-Heimbach, Vincent Chouraki, Amanda B Kuzma, Kristel Sleegers, Maria Vronskaya, Agustin Ruiz, Robert R Graham, Robert Olaso, Per Hoffmann, Megan L Grove, Badri N Vardarajan, Mikko Hiltunen, Markus M Nöthen, Charles C White, Kara L Hamilton-Nelson, Jacques Epelbaum, Wolfgang Maier, Seung-Hoan Choi, Gary W Beecham, Cécile Dulary, Stefan Herms, Albert V Smith, Cory C Funk, Céline Derbois, Andreas J Forstner, Shahzad Ahmad, Hongdong Li, Delphine Bacq, Denise Harold, Claudia L Satizabal, Otto Valladares, Alessio Squassina, Rhodri Thomas, Jennifer A Brody, Liming Qu, Pascual Sánchez-Juan, Taniesha Morgan, Frank J Wolters, Yi Zhao, Florentino Sanchez Garcia, Nicola Denning, Myriam Fornage, John Malamon, Maria Candida Deniz Naranjo, Elisa Majounie, Thomas H Mosley, Beth Dombroski, David Wallon, Michelle K Lupton, Josée Dupuis, Patrice Whitehead, Laura Fratiglioni, Christopher Medway, Xueqiu Jian, Shubhabrata Mukherjee, Lina Keller, Kristelle Brown, Honghuang Lin, Laura B Cantwell, Francesco Panza, Bernadette McGuinness, Sonia Moreno-Grau, Jeremy D Burgess, Vincenzo Solfrizzi, Petra Proitsi, Hieab H Adams, Mariet Allen, Davide Seripa, Pau Pastor, L Adrienne Cupples, Nathan D Price, Didier Hannequin, Ana Frank-García, Daniel Levy, Paramita Chakrabarty, Paolo Caffarra, Ina Giegling, Alexa S Beiser, Vilmantas Giedraitis, Harald Hampel, Melissa E Garcia, Xue Wang, Lars Lannfelt, Patrizia Mecocci, Gudny Eiriksdottir, Paul K Crane, Florence Pasquier, Virginia Boccardi, Isabel Henández, Robert C Barber, Martin Scherer, Lluis Tarraga, Perrie M Adams, Markus Leber, Yuning Chen, Marilyn S Albert, Steffi Riedel-Heller, Valur Emilsson, Duane Beekly, Anne Braae, Reinhold Schmidt, Deborah Blacker, Carlo Masullo, Helena Schmidt, Rachelle S Doody, Gianfranco Spalletta, W T Longstreth, Thomas J Fairchild, Paola Bossù, Oscar L Lopez, Matthew P Frosch, Eleonora Sacchinelli, Bernardino Ghetti, Qiong Yang, Ryan M Huebinger, Frank Jessen, Shuo Li, M Ilyas Kamboh, John Morris, Oscar Sotolongo-Grau, Mindy J Katz, Chris Corcoran, Melanie Dunstan, Amy Braddel, Charlene Thomas, Alun Meggy, Rachel Marshall, Amy Gerrish, Jade Chapman, Miquel Aguilar, Sarah Taylor, Matt Hill, Mònica Díez Fairén, Angela Hodges, Bruno Vellas, Hilkka Soininen, Iwona Kloszewska, Makrina Daniilidou, James Uphill, Yogen Patel, Joseph T Hughes, Jenny Lord, James Turton, Annette M Hartmann, Roberta Cecchetti, Chiara Fenoglio, Maria Serpente, Marina Arcaro, Carlo Caltagirone, Maria Donata Orfei, Antonio Ciaramella, Sabrina Pichler, Manuel Mayhaus, Wei Gu, Alberto Lleó, Juan Fortea, Rafael Blesa, Imelda S Barber, Keeley Brookes, Chiara Cupidi, Raffaele Giovanni Maletta, David Carrell, Sandro Sorbi, Susanne Moebus, Maria Urbano, Alberto Pilotto, Johannes Kornhuber, Paolo Bosco, Stephen Todd, David Craig, Janet Johnston, Michael Gill, Brian Lawlor, Aoibhinn Lynch, Nick C Fox, John Hardy, Roger L Albin, Liana G Apostolova, Steven E Arnold, Sanjay Asthana, Craig S Atwood, Clinton T Baldwin, Lisa L Barnes, Sandra Barral, Thomas G Beach, James T Becker, Eileen H Bigio, Thomas D Bird, Bradley F Boeve, James D Bowen, Adam Boxer, James R Burke, Jeffrey M Burns, Joseph D Buxbaum, Nigel J Cairns, Chuanhai Cao, Chris S Carlson, Cynthia M Carlsson, Regina M Carney, Minerva M Carrasquillo, Steven L Carroll, Carolina Ceballos Diaz, Helena C Chui, David G Clark, David H Cribbs, Elizabeth A Crocco, Charles DeCarli, Malcolm Dick, Ranjan Duara, Denis A Evans, Kelley M Faber, Kenneth B Fallon, David W Fardo, Martin R Farlow, Steven Ferris, Tatiana M Foroud, Douglas R Galasko, Marla Gearing, Daniel H Geschwind, John R Gilbert, Neill R Graff-Radford, Robert C Green, John H Growdon, Ronald L Hamilton, Lindy E Harrell, Lawrence S Honig, Matthew J Huentelman, Christine M Hulette, Bradley T Hyman, Gail P Jarvik, Erin Abner, Lee-Way Jin, Gyungah Jun, Anna Karydas, Jeffrey A Kaye, Ronald Kim, Neil W Kowall, Joel H Kramer, Frank M LaFerla, James J Lah, James B Leverenz, Allan I Levey, Ge Li, Andrew P Lieberman, Kathryn L Lunetta, Constantine G Lyketsos, Daniel C Marson, Frank Martiniuk, Deborah C Mash, Eliezer Masliah, Wayne C McCormick, Susan M McCurry, Andrew N McDavid, Ann C McKee, Marsel Mesulam, Bruce L Miller, Carol A Miller, Joshua W Miller, John C Morris, Jill R Murrell, Amanda J Myers, Sid O'Bryant, John M Olichney, Vernon S Pankratz, Joseph E Parisi, Henry L Paulson, William Perry, Elaine Peskind, Aimee Pierce, Wayne W Poon, Huntington Potter, Joseph F Quinn, Ashok Raj, Murray Raskind, Barry Reisberg, Christiane Reitz, John M Ringman, Erik D Roberson, Ekaterina Rogaeva, Howard J Rosen, Roger N Rosenberg, Mark A Sager, Andrew J Saykin, Julie A Schneider, Lon S Schneider, William W Seeley, Amanda G Smith, Joshua A Sonnen, Salvatore Spina, Robert A Stern, Russell H Swerdlow, Rudolph E Tanzi, Tricia A Thornton-Wells, John Q Trojanowski, Juan C Troncoso, Vivianna M Van Deerlin, Linda J Van Eldik, Harry V Vinters, Jean Paul Vonsattel, Sandra Weintraub, Kathleen A Welsh-Bohmer, Kirk C Wilhelmsen, Jennifer Williamson, Thomas S Wingo, Randall L Woltjer, Clinton B Wright, Chang-En Yu, Lei Yu, Fabienne Garzia, Feroze Golamaully, Gislain Septier, Sebastien Engelborghs, Rik Vandenberghe, Peter P De Deyn, Carmen Muñoz Fernadez, Yoland Aladro Benito, Hakan Thonberg, Charlotte Forsell, Lena Lilius, Anne Kinhult-Stählbom, Lena Kilander, RoseMarie Brundin, Letizia Concari, Seppo Helisalmi, Anne Maria Koivisto, Annakaisa Haapasalo, Vincent Dermecourt, Nathalie Fievet, Olivier Hanon, Carole Dufouil, Alexis Brice, Karen Ritchie, Bruno Dubois, Jayanadra J Himali, C Dirk Keene, JoAnn Tschanz, Annette L Fitzpatrick, Walter A Kukull, Maria Norton, Thor Aspelund, Eric B Larson, Ron Munger, Jerome I Rotter, Richard B Lipton, María J Bullido, Albert Hofman, Thomas J Montine, Eliecer Coto, Eric Boerwinkle, Ronald C Petersen, Victoria Alvarez, Fernando Rivadeneira, Eric M Reiman, Maura Gallo, Christopher J O'Donnell, Joan S Reisch, Amalia Cecilia Bruni, Donald R Royall, Martin Dichgans, Mary Sano, Daniela Galimberti, Peter St George-Hyslop, Elio Scarpini, Debby W Tsuang, Michelangelo Mancuso, Ubaldo Bonuccelli, Ashley R Winslow, Antonio Daniele, Chuang-Kuo Wu, Oliver Peters, Benedetta Nacmias, Matthias Riemenschneider, Reinhard Heun, Carol Brayne, David C Rubinsztein, Jose Bras, Rita Guerreiro, Ammar Al-Chalabi, Christopher E Shaw, John Collinge, David Mann, Magda Tsolaki, Jordi Clarimón, Rebecca Sussams, Simon Lovestone, Michael C O'Donovan, Michael J Owen, Timothy W Behrens, Simon Mead, Alison M Goate, Andre G Uitterlinden, Clive Holmes, Carlos Cruchaga, Martin Ingelsson, David A Bennett, John Powell, Todd E Golde, Caroline Graff, Philip L De Jager, Kevin Morgan, Nilufer Ertekin-Taner, Onofre Combarros, Bruce M Psaty, Peter Passmore, Steven G Younkin, Claudine Berr, Vilmundur Gudnason, Dan Rujescu, Dennis W Dickson, Jean-François Dartigues, Anita L DeStefano, Sara Ortega-Cubero, Hakon Hakonarson, Dominique Campion, Merce Boada, John Keoni Kauwe, Lindsay A Farrer, Christine Van Broeckhoven, M Arfan Ikram, Lesley Jones, Jonathan L Haines, Christophe Tzourio, Lenore J Launer, Valentina Escott-Price, Richard Mayeux, Jean-François Deleuze, Najaf Amin, Peter A Holmans, Margaret A Pericak-Vance, Philippe Amouyel, Cornelia M van Duijn, Alfredo Ramirez, Li-San Wang, Jean-Charles Lambert, Sudha Seshadri, Julie Williams, Gerard D Schellenberg
We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 × 10-4 ) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, we used an additional 14,997 samples to test the most significant stage 2 associations (P < 5 × 10-8 ) using imputed genotypes. We observed three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease: a protective variant in PLCG2 (rs72824905: p...
September 2017: Nature Genetics
#33
JOURNAL ARTICLE
Xavier Pivot, Gilles Romieu, Pierre Fumoleau, Maria Rios, Hervé Bonnefoi, Thomas Bachelot, Patrick Soulié, Christelle Jouannaud, Hugues Bourgeois, Thierry Petit, Isabelle Tennevet, David Assouline, Marie-Christine Mathieu, Jean-Philippe Jacquin, Sandrine Lavau-Denes, Ariane Darut-Jouve, Jean-Marc Ferrero, Carole Tarpin, Christelle Lévy, Valérie Delecroix, Véronique Trillet-Lenoir, Oana Cojocarasu, Jérôme Meunier, Jean-Yves Pierga, Cécile Agostini, Pierre Kerbrat, Céline Faure-Mercier, Hélène Blanché, Mourad Sahbatou, Anne Boland, Delphine Bacq, Céline Besse, Fabien Calvo, Alexia Renaud, Jean-François Deleuze, Iris Pauporté, Gilles Thomas, David G Cox
Human epidermal growth factor receptor 2-positive breast cancer is a subtype of interest regarding its outcome and the impressive impact of human epidermal growth factor receptor 2 targeted therapy. Constitutional variants may be involved in the aetiology of human epidermal growth factor receptor 2-positive breast cancer, and we propose a case-case study to test the hypothesis that single nucleotide polymorphisms may be associated with human epidermal growth factor receptor 2 status. A Genome-Wide Association Study was used in a cohort of 9836 patients from the SIGNAL/PHARE study (NCT00381901-RECF1098)...
2017: NPJ Breast Cancer
#34
REVIEW
Joe Cambray
The complexity associated with deep interconnectedness in nature is beginning to be articulated and elaborated in the field of ecological studies. While some parallels to the psyche have been made and the field of Eco-psychology has been developing, Jung's explicit contribution by way of the image of rhizomes has not been considered in detail. Philosopher Gilles Deleuze acknowledges borrowing the term from Jung, though he disagreed with Jung's Empedoclean use of the term. The paper presents some fundamental properties of rhizomes along with contemporary scientific research on mycorrhizal (fungal) networks...
February 2017: Journal of Analytical Psychology
#35
JOURNAL ARTICLE
Emil Øversveen, Håvard T Rydland, Clare Bambra, Terje A Eikemo
AIM: The aim of this study is to analyse previous explanations of social inequality in health and argue for a closer integration of sociological theory into future empirical research. METHODS: We examine cultural-behavioural, materialist, psychosocial and life-course approaches, in addition to fundamental cause theory. Giddens' structuration theory and a neo-materialist approach, inspired by Bruno Latour, Gilles Deleuze and Felix Guattari, are proposed as ways of rethinking the causal relationship between socio-economic status and health...
March 2017: Scandinavian Journal of Public Health
#36
JOURNAL ARTICLE
Billie Jeanne Brownlee, Maziyar Ghiabi
To counter the trend toward mechanization of research and aridity of critical analysis, this article makes a case for an interdisciplinary quest. To borrow Felix Guattari and Gilles Deleuze's phrase, we are convinced that 'everything is political, but every politics is simultaneously a macropolitics and a micropolitics.' With an eye to open-ended research questions, this article attempts to build a body of theoretical, political and anthropological considerations, which, it is hoped, could function as a case of enquiry into the mechanics of power, revolt and revolution...
2016: Middle East Critique
#37
MULTICENTER STUDY
David G Cox, Elsa Curtit, Gilles Romieu, Pierre Fumoleau, Maria Rios, Hervé Bonnefoi, Thomas Bachelot, Patrick Soulié, Christelle Jouannaud, Hugues Bourgeois, Thierry Petit, Isabelle Tennevet, David Assouline, Marie-Christine Mathieu, Jean-Philippe Jacquin, Sandrine Lavau-Denes, Ariane Darut-Jouve, Jean-Marc Ferrero, Carole Tarpin, Christelle Lévy, Valérie Delecroix, Véronique Trillet-Lenoir, Oana Cojocarasu, Jérôme Meunier, Jean-Yves Pierga, Céline Faure-Mercier, Hélène Blanché, Mourad Sahbatou, Anne Boland, Delphine Bacq, Céline Besse, Jean-François Deleuze, Iris Pauporté, Gilles Thomas, Xavier Pivot
Genetic polymorphisms are associated with breast cancer risk. Clinical and epidemiological observations suggest that clinical characteristics of breast cancer, such as estrogen receptor or HER2 status, are also influenced by hereditary factors. To identify genetic variants associated with pathological characteristics of breast cancer patients, a Genome Wide Association Study was performed in a cohort of 9365 women from the French nationwide SIGNAL/PHARE studies (NCT00381901/RECF1098). Strong association between the FGFR2 locus and ER status of breast cancer patients was observed (ER-positive n=6211, ER-negative n=2516; rs3135718 OR=1...
November 22, 2016: Oncotarget
#38
JOURNAL ARTICLE
Anthony Ferrari, Anne Vincent-Salomon, Xavier Pivot, Anne-Sophie Sertier, Emilie Thomas, Laurie Tonon, Sandrine Boyault, Eskeatnaf Mulugeta, Isabelle Treilleux, Gaëtan MacGrogan, Laurent Arnould, Janice Kielbassa, Vincent Le Texier, Hélène Blanché, Jean-François Deleuze, Jocelyne Jacquemier, Marie-Christine Mathieu, Frédérique Penault-Llorca, Frédéric Bibeau, Odette Mariani, Cécile Mannina, Jean-Yves Pierga, Olivier Trédan, Thomas Bachelot, Hervé Bonnefoi, Gilles Romieu, Pierre Fumoleau, Suzette Delaloge, Maria Rios, Jean-Marc Ferrero, Carole Tarpin, Catherine Bouteille, Fabien Calvo, Ivo Glynne Gut, Marta Gut, Sancha Martin, Serena Nik-Zainal, Michael R Stratton, Iris Pauporté, Pierre Saintigny, Daniel Birnbaum, Alain Viari, Gilles Thomas
HER2-positive breast cancer has long proven to be a clinically distinct class of breast cancers for which several targeted therapies are now available. However, resistance to the treatment associated with specific gene expressions or mutations has been observed, revealing the underlying diversity of these cancers. Therefore, understanding the full extent of the HER2-positive disease heterogeneity still remains challenging. Here we carry out an in-depth genomic characterization of 64 HER2-positive breast tumour genomes that exhibit four subgroups, based on the expression data, with distinctive genomic features in terms of somatic mutations, copy-number changes or structural variations...
July 13, 2016: Nature Communications
#39
JOURNAL ARTICLE
George Huntington
No abstract text is available yet for this article.
July 2016: British Journal of Psychiatry
#40
JOURNAL ARTICLE
Maria Vaccarella
This article explores the often perplexing experience of being an epilepsy surgery candidate, as portrayed in four book-length accounts: Laura Doermer's Moritz mein Sohn (Moritz my son, 1990), David B.'s L'ascension du haut mal (The ascent of the high evil, 1996; published in English as Epileptic, 2003), Ray Robinson's Electricity (2006), and Alberto Capitta's Il giardino non esiste (The garden doesn't exist, 2009). Building upon critical disability studies and the work of French poststructuralists Gilles Deleuze and Félix Guattari, I analyze issues of embodiment, identity and narrative (re)construction in the postsurgical alleviation of chronic illness...
2015: Literature and Medicine
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