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https://www.readbyqxmd.com/read/29348825/a-novel-anti-cd146-antibody-specifically-targets-cancer-cells-by-internalizing-the-molecule
#1
Marie Nollet, Jimmy Stalin, Anaïs Moyon, Waël Traboulsi, Amel Essaadi, Stéphane Robert, Nausicaa Malissen, Richard Bachelier, Laurent Daniel, Alexandrine Foucault-Bertaud, Caroline Gaudy-Marqueste, Romaric Lacroix, Aurélie S Leroyer, Benjamin Guillet, Nathalie Bardin, Françoise Dignat-George, Marcel Blot-Chabaud
CD146 is an adhesion molecule present on many tumors (melanoma, kidney, pancreas, breast, ...). In addition, it has been shown to be expressed on vascular endothelial and smooth muscle cells. Generating an antibody able to specifically recognize CD146 in cancer cells (designated as tumor CD146), but not in normal cells, would thus be of major interest for targeting tumor CD146 without affecting the vascular system. We thus generated antibodies against the extracellular domain of the molecule produced in cancer cells and selected an antibody that specifically recognizes tumor CD146...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29302160/intersectional-discrimination-of-romani-women-forcibly-sterilized-in-the-former-czechoslovakia-and-czech-republic
#2
Gwendolyn Albert, Marek Szilvasi
This paper reviews domestic and international activism seeking justice for Romani and other women harmed by coercive, forced, and involuntary sterilization in the former Czechoslovakia and Czech Republic. Framed by Michel Foucault's theory of biopower, it summarizes the history of these abuses and describes human rights campaigns involving domestic and international litigation, advocacy, and grassroots activism, as well as the responses of the Czech governments. The paper describes how legal and policy work during the past decade has led to recognition of coercive, forced, and involuntary sterilization as a present-day human rights issue worldwide, to the adoption of new guidelines on female sterilization, and to a joint statement on the issue by seven UN agencies...
December 2017: Health and Human Rights
https://www.readbyqxmd.com/read/29286342/impact-of-interprofessional-relationships-from-nurses-perspective-on-the-decision-making-capacity-of-patients-in-a-clinical-setting
#3
Jesús Molina-Mula, Julia Gallo-Estrada, Catalina Perelló-Campaner
Interprofessional relationships may impact the decision making of patients in a clinical setting. The objective of this study was to analyse the decision-making capabilities of patients from nurses' perspectives of interprofessional relationships using Foucauldian ethics. This qualitative study was based on poststructuralist Foucault references with in-depth interviews of nurses working in internal medicine and specialties in a general hospital. The patients constantly appeared in the definition of teamwork, but also as a passive element used by every professional to communicate with others...
December 29, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29283037/a-critique-of-medicalisation-three-instances
#4
Sonia Ryang
By briefly exploring three different examples where the existence of mental illness and developmental delay has been presumed, this paper sheds light on the way what Foucault calls the emergence of a regime of truth, i.e. where something that does not exist is made to exist through the construction of a system of truth around it. The first example concerns the direct marketing of pharmaceutical products to consumers in the US, the second the use of psychology in semi-post-Cold War Korea, and the third the persisting authority of psychology in the treatment of the developmentally delayed...
December 2017: Anthropology & Medicine
https://www.readbyqxmd.com/read/29278249/governing-the-resilience-of-neoliberalism-through-biopolitics
#5
Luca Mavelli
Neoliberalism is widely regarded as the main culprit for the 2007/2008 global financial crisis. However, despite this abysmal failure, neoliberalism has not merely survived the crisis, but actually 'thrived'. How is it possible to account for the resilience of neoliberalism? Existing scholarship has answered this question either by focusing on the distinctive qualities of neoliberalism (such as adaptability, internal coherence and capacity to incorporate dissent) or on the biopolitical capacity of neoliberalism to produce resilient subjects...
September 2017: Eur J Int Relat
https://www.readbyqxmd.com/read/29261571/factors-influencing-acceptability-and-perceived-impacts-of-a-mandatory-eportfolio-implemented-by-an-occupational-therapy-regulatory-organization
#6
Brigitte Vachon, Marie-Lyse Foucault, Charles-Édouard Giguère, Annie Rochette, Aliki Thomas, Martine Morel
INTRODUCTION: The use of ePortfolios has been implemented in several regulatory organizations to encourage clinicians' engagement in continuing professional development (CPD). However, their use has achieved mixed success, and multiple personal and contextual factors can influence their impacts on practice change. The aim of this study was to identify which factors influence the acceptability and perceived impacts of an ePortfolio implemented by an occupational therapy regulatory organization in one Canadian province...
December 19, 2017: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/29240820/age-related-nomograms-for-antral-follicle-count-and-anti-mullerian-hormone-for-subfertile-chinese-women-in-singapore
#7
See Ling Loy, Yin Bun Cheung, Marielle Valerie Fortier, Chiou Li Ong, Heng Hao Tan, Sadhana Nadarajah, Jerry Kok Yen Chan, Veronique Viardot-Foucault
BACKGROUND: Antral follicle count (AFC) and anti-Mullerian hormone (AMH) are known as the most reliable markers of a woman's ovarian reserve and are related to age. There is currently no specific local age-related centile charts for AFC and AMH. Therefore, we aim to examine the relationship between AFC and AMH with age and construct age-related nomograms among a subfertile Asian population. METHODS: This is a study involving Chinese women who had their AFC and AMH measured as part of their subfertility screening from December 2010 until November 2014 in KK Women's and Children's Hospital, Singapore...
2017: PloS One
https://www.readbyqxmd.com/read/29237308/how-can-governmental-positive-power-decrease-violence-in-crime-oriented-arenas-the-case-of-english-football
#8
Shlomit Guy, Ofer Muchtar, Natti Ronel
This article will survey the dramatic change English football had undergone since the end of the last century. The authors will closely explore the implementation of the Taylor Report recommendations, to convince that which power and management techniques were used to decrease violence in public areas that were previously considered dangerous and crime-oriented. It will be argued that disciplinarian techniques were practiced, much like those described in Foucault's Discipline and Punish, while this very power has proven to be positive and revitalizing...
January 1, 2017: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/29235234/-holding-on-to-life-an-ethnographic-study-of-living-well-at-home-in-old-age
#9
Kristin Bjornsdottir
In recent years, much attention has been paid to how older people living at home can remain independent and manage their illness themselves, while less attention has been given to those who have become frail and need assistance with challenges of everyday life. In this article, I drew on Latimer's formulation of care for frail older people as relational and world-making and on Foucault's work related to the care of the self in developing an understanding of how frail older persons manage to live well at home in the final years of their lives...
December 13, 2017: Nursing Inquiry
https://www.readbyqxmd.com/read/29192463/le-secret-professionnel-soignant%C3%A2-un-enjeu-de-d%C3%A3-mocratie-sanitaire-entre-immanence-et-ali%C3%A3-nation
#10
Silvère Pautier
For a long time considered as total and absolute, healthcare professional secrecy is today difficult to reconcile with care practices. Lots of paradoxes question its preservation in favour of general interest and public order against the protection of private interest within an individualistic normative society. Exploring this interrogation, the article's objective is to initiate an ethical discussion from a professional caregiver secrecy's historical and sociological evolution perspective. Thus, with the help of theoretical understandings, especially those by Michel Foucault, medical secrecy is considered a defense of rationality specific to populations' government...
November 21, 2017: Recherche en Soins Infirmiers
https://www.readbyqxmd.com/read/29143430/power-discourse-and-resistance-poststructuralist-influences-in-nursing
#11
Dave Holmes, Marilou Gagnon
Based on our respective research programs (psychiatry, forensic psychiatry, public health, HIV/AIDS, harm reduction) this article aims to use purposely non-conventional means to present the substantial contribution of poststructuralist perspectives to knowledge development in nursing science in general and in our current research in particular. More specifically, we call on the work of Michel Foucault and Deleuze & Guattari to politicize nursing science using examples from our empirical research programs with marginal and often highly marginalized populations...
November 15, 2017: Nursing Philosophy: An International Journal for Healthcare Professionals
https://www.readbyqxmd.com/read/29089979/therapeutic-potential-of-%C3%AE-7-nicotinic-receptor-agonists-to-regulate-neuroinflammation-in-neurodegenerative-diseases
#12
REVIEW
Laura Foucault-Fruchard, Daniel Antier
Neurodegenerative diseases, such as Alzheimer's, Parkinson's and Huntington's diseases, are all characterized by a component of innate immunity called neuroinflammation. Neuronal loss and neuroinflammation are two phenomena closely linked. Hence, the neuroinflammation is a relevant target for the management of the neurodegenerative diseases given that, to date, there is no treatment to stop neuronal loss. Several studies have investigated the potential effects of activators of alpha 7 nicotinic acetylcholine receptors in animal models of neurodegenerative diseases...
September 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29074486/metabolic-markers-of-protein-maldigestion-after-a-15-n-test-meal-in-minipigs-with-pancreatic-exocrine-insufficiency
#13
Florence Mary, Anne Moesseler, Nadezda Khodorova, Angélique Foucault-Simonin, Robert Benamouzig, Daniel Tomé, Peter Colin Gregory, Claire Gaudichon
The effect of pancreatic exocrine insufficiency (PEI) on protein malabsorption is little documented, partly due to methodological barriers. We aimed to validate biomarkers of protein malabsorption using a (15)N test meal in a minipig model of PEI. Six pancreatic duct-ligated minipigs were used as a model of PEI and four non-operated animals as a control. All animals were equipped with an ileo-caecal re-entrant cannula. Minipigs were given a test meal containing (15)N casein. The PEI animals repeated the test 3 times, in the absence of any pancreatic enzymes, or after pancreatic substitution at 2 levels (A or B: 7500 or 75,000 (lipase) and 388 or 3881 (protease) FIP U)...
October 26, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29072329/disciplinary-power-and-the-process-of-training-informal-carers-on-stroke-units
#14
Euan Sadler, Rebecca Hawkins, David J Clarke, Mary Godfrey, Josie Dickerson, Christopher McKevitt
This article examines the process of training informal carers on stroke units using the lens of power. Care is usually assumed as a kinship obligation but the state has long had an interest in framing the carer and caring work. Training carers in healthcare settings raises questions about the power of the state and healthcare professionals as its agents to shape expectations and practices related to the caring role. Drawing on Foucault's notion of disciplinary power, we show how disciplinary forms of power exercised in interactions between healthcare professionals and carers shape the engagement and resistance of carers in the process of training...
October 26, 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29050735/-inferior-myocardial-infarction-complicated-by-complete-heart-block-and-cardiac-arrest-following-a-gadolinium-injection-a-case-of-kounis-syndrome
#15
R Demoulin, R Poyet, E Capilla, M Cardinale, A V Tortat, F Pons, F-X Brocq, C Jego, G Foucault, G-R Cellarier
Kounis syndrome is an allergic acute coronary syndrome. It occurs on healthy or pathological arteries. Its complications, although often benign, can lead to cardiac arrest and death. Its triggering factors are multiple and include contrast products used in diagnostic imaging. We report the case of an 81 years old patient affected by hepatocellular carcinoma, who presented a type 2 Kounis syndrome with inferior myocardial infarction, complicated by cardiac arrest related to complete heart block following a gadoteric acid injection...
November 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/28992541/pastoral-power-in-hiv-prevention-converging-rationalities-of-care-in-christian-and-medical-practices-in-papua-new-guinea
#16
P Shih, H Worth, J Travaglia, A Kelly-Hanku
In his conceptualisation of pastoral power, Michel Foucault argues that modern healthcare practices derive a specific power technique from pastors of the early Christian church. As experts in a position of authority, pastors practise the care of others through implicitly guiding them towards thoughts and actions that effect self-care, and towards a predefined realm of acceptable conduct, thus having a regulatory effect. This qualitative study of healthcare workers from two Christian faith-based organisations in Papua New Guinea examines the pastoral rationalities of HIV prevention practices which draw together globally circulated modern medical knowledge and Christian teachings in sexual morality for implicit social regulation...
November 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28952175/reconciling-conceptualizations-of-ethical-conduct-and-person-centred-care-of-older-people-with-cognitive-impairment-in-acute-care-settings
#17
Carole Rushton, David Edvardsson
Key commentators on person-centred care have described it as a "new ethic of care" which they link inextricably to notions of individual autonomy, action, change and improvement. Two key points are addressed in this article. The first is that few discussions about ethics and person-centred are underscored by any particular ethical theory. The second point is that despite the espoused benefits of person-centred care, delivery within the acute care setting remains largely aspirational. Choices nurses make about their practice tend to comply more often with prevailing norms than those championed by person-centred care...
September 26, 2017: Nursing Philosophy: An International Journal for Healthcare Professionals
https://www.readbyqxmd.com/read/28944628/-understanding-the-use-of-mechanical-restraints-in-psychiatry-phenomenological-study-of-nurses%C3%A2-lived-experience
#18
Pascale Corneau, Jean Daniel Jacob, Dave Holmes, Desire Rioux
The use of mechanical restraints in psychiatric settings is currently the subject of ethical controversy. However, both patients' and nurses' voices are absent in the debate over this controversial intervention. The objective of this qualitative study was to examine the experience of psychiatric nurses using mechanical restraints. Twentyone nurses working on either the acute psychiatric inpatient unit and/or the emergency psychiatric unit of a university affiliated Canadian hospital participated in semi-structured interviews, which were then transcribed, coded and analyzed using the interpretative phenomenological analysis (IPA) method...
April 19, 2017: Recherche en Soins Infirmiers
https://www.readbyqxmd.com/read/28901599/balancing-bioethics-by-sensing-the-aesthetic
#19
Paul Macneill
This article is critical of "bioethics" as it is widely understood and taught, noting in particular an emphasis given to philosophical justification, reason and rationality. It is proposed that "balancing" bioethics be achieved by giving greater weight to practice and the aesthetic: Defined in terms of sensory perception, emotion and feeling. Each of those three elements is elaborated as a non-cognitive capacity and, when taken together, comprise aesthetic sensitivity and responsiveness. This is to recognise the aesthetic as a productive element in bioethics as practice...
October 2017: Bioethics
https://www.readbyqxmd.com/read/28886888/thinking-with-pleasure-experimenting-with-drugs-and-drug-research
#20
Kane Race
Within the field of drug and alcohol studies, researchers think about pleasure or against it; we analyse, consider, investigate, invoke or ignore it. The philosophically inclined may think of pleasure or write on it, but in each of these scenarios pleasure is kept at an arm's length while the researcher appears to remain unmoved - detached observers, objective scientists, conceptual experts, program directors, sharp critics, policy advocates - sober judges whose sovereignty is secured by the formal conventions of positivist research, established theory, institutional authority and/or disciplinary knowledge...
September 5, 2017: International Journal on Drug Policy
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