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https://www.readbyqxmd.com/read/29691769/long-term-effects-of-chemical-warfare-on-post-traumatic-stress-disorder-depression-and-chronic-medical-conditions-in-veterans
#1
Hamideh Safi-Aghdam, Mehrzad Shafie, Alireza Khoshdel, Ehsan Moazen-Zadeh, Farhad Avakh, Arash Rahmani
We investigated the association between exposure to chemical warfare and chronic mental/physical conditions. This was a secondary analysis of data from a case-control study on Iranian male veterans. Participants with neuropsychiatric disorders other than depressive/anxiety disorders, anatomical defects, or malignancies were excluded. Compared to non-exposed veterans, exposed veterans demonstrated significantly higher odds of PTSD [OR (95% CI) = 5.23 (1.98-13.85)], hypertension [OR (95% CI) = 5.57 (1.68-18...
April 24, 2018: Community Mental Health Journal
https://www.readbyqxmd.com/read/29691578/-effects-of-thyroid-hormone-on-macrophage-dysfunction-induced-by-oxidized-low-density-lipoprotein
#2
Yu Ning, Ming Zhang, Yun-Hui DU, Hui-Na Zhang, Lin-Yi Li, Yan-Wen Qin, Wan-Wan Wen, Quan-Ming Zhao
It has been recognized that patients with hypothyroidism have higher risks of atherosclerosis and coronary heart disease, however, the mechanisms are largely unknown. Considering that macrophage dysfunction plays an important role in the formation and development of atherosclerosis plaques, this study aimed to investigate the direct effects of thyroid hormone on macrophage functions and to provide new insight for the mechanism of hypothyroid atherosclerosis. RAW264.7 cells (mouse leukaemic monocyte macrophage cell line) were incubated with oxidized low-density lipoprotein (oxLDL) to establish macrophage foam cells model in vitro, and the protective effects of different concentration of thyroxine (T4) on the macrophage foam cells function were explored...
April 25, 2018: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/29691431/biological-insights-into-muscular-strength-genetic-findings-in-the-uk-biobank
#3
Emmi Tikkanen, Stefan Gustafsson, David Amar, Anna Shcherbina, Daryl Waggott, Euan A Ashley, Erik Ingelsson
We performed a large genome-wide association study to discover genetic variation associated with muscular strength, and to evaluate shared genetic aetiology with and causal effects of muscular strength on several health indicators. In our discovery analysis of 223,315 individuals, we identified 101 loci associated with grip strength (P <5 × 10-8 ). Of these, 64 were associated (P < 0.01 and consistent direction) also in the replication dataset (N = 111,610). eQTL analyses highlighted several genes known to play a role in neuro-developmental disorders or brain function, and the results from meta-analysis showed a significant enrichment of gene expression of brain-related transcripts...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29691397/non-invasive-detection-of-human-cardiomyocyte-death-using-methylation-patterns-of-circulating-dna
#4
Hai Zemmour, David Planer, Judith Magenheim, Joshua Moss, Daniel Neiman, Dan Gilon, Amit Korach, Benjamin Glaser, Ruth Shemer, Giora Landesberg, Yuval Dor
Detection of cardiomyocyte death is crucial for the diagnosis and treatment of heart disease. Here we use comparative methylome analysis to identify genomic loci that are unmethylated specifically in cardiomyocytes, and develop these as biomarkers to quantify cardiomyocyte DNA in circulating cell-free DNA (cfDNA) derived from dying cells. Plasma of healthy individuals contains essentially no cardiomyocyte cfDNA, consistent with minimal cardiac turnover. Patients with acute ST-elevation myocardial infarction show a robust cardiac cfDNA signal that correlates with levels of troponin and creatine phosphokinase (CPK), including the expected elevation-decay dynamics following coronary angioplasty...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29688940/robotic-beating-heart-totally-endoscopic-coronary-artery-bypass-in-higher-risk-patients-can-it-be-done-safely
#5
Husam H Balkhy, Sarah Nisivaco, Hiroto Kitahara, Mackenzie McCrorey, Brooke Patel
OBJECTIVE: Patients with a high Society of Thoracic Surgeons (STS) predicted risk of mortality undergoing coronary artery bypass surgery are known to have worse outcomes. Less invasive approaches have been shown to improve morbidity and mortality for these patients. In this study, we examined perioperative outcomes in higher-risk patients undergoing robotic totally endoscopic beating heart coronary artery bypass surgery. METHODS: The STS predicted risk of mortality was reviewed for patients undergoing robotic totally endoscopic beating heart coronary artery bypass surgery at our institution between January 2013 and May 2017...
April 23, 2018: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29688759/relations-between-the-residential-fast-food-environment-and-the-individual-risk-of-cardiovascular-diseases-in-the-netherlands-a-nationwide-follow-up-study
#6
Maartje Poelman, Maciej Strak, Oliver Schmitz, Gerard Hoek, Derek Karssenberg, Marco Helbich, Anna-Maria Ntarladima, Michiel Bots, Bert Brunekreef, Rick Grobbee, Martin Dijst, Ilonca Vaartjes
Background The food environment has been hypothesized to influence cardiovascular diseases such as hypertension and coronary heart disease. This study determines the relation between fast-food outlet density (FFD) and the individual risk for cardiovascular disease, among a nationwide Dutch sample. Methods After linkage of three national registers, a cohort of 2,472,004 adults (≥35 years), free from cardiovascular disease at January 1st 2009 and living at the same address for ≥15 years was constructed. Participants were followed for one year to determine incidence of cardiovascular disease, including coronary heart disease, stroke and heart failure...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29688297/ten-year-association-of-coronary-artery-calcium-with-atherosclerotic-cardiovascular-disease-ascvd-events-the-multi-ethnic-study-of-atherosclerosis-mesa
#7
Matthew J Budoff, Rebekah Young, Gregory Burke, J Jeffrey Carr, Robert C Detrano, Aaron R Folsom, Richard Kronmal, Joao A C Lima, Kiang J Liu, Robyn L McClelland, Erin Michos, Wendy S Post, Steven Shea, Karol E Watson, Nathan D Wong
Aims: While coronary artery calcium (CAC) has been extensively validated for predicting clinical events, most outcome studies of CAC have evaluated coronary heart disease (CHD) rather than atherosclerotic cardiovascular disease (ASCVD) events (including stroke). Also, virtually all CAC studies are of short- or intermediate-term follow-up, so studies across multi-ethnic cohorts with long-term follow-up are warranted prior to widespread clinical use. We sought to evaluate the contribution of CAC using the population-based MESA cohort with over 10 years of follow-up for ASCVD events, and whether the association of CAC with events varied by sex, race/ethnicity, or age category...
April 23, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29687864/the-molecular-mechanism-of-serum-microrna124b-induced-coronary-heart-disease-by-inducing-myocardial-cell-senescence
#8
M-L Guo, L-L Guo, Q-J Qin, Y-Q Weng, Y-N Wang, J Yao, Y-B Wang, X-Z Zhang, Z-M Ge
OBJECTIVE: The incidence and mortality of coronary heart disease are rapidly increasing in recent years. Myocardial cell dysfunction and cell senescence may play a role in coronary heart disease. MicroRNA controls a variety of biological processes, but leaving its role in coronary heart disease has yet to be explored. PATIENTS AND METHODS: Patients with coronary heart disease were regarded as subjects, and healthy volunteers as the control, on both of which microRNA124b level of serum was studied by Real-time PCR, and the heart function of patients was detected by using ultrasound...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29687698/microcirculatory-dysfunction-in-the-heart-and-the-brain
#9
Hernán Mejía-Rentería, Jordi A Matias-Guiu, Francesco Lauri, Miguel Yus, Javier Escaned
Coronary microcirculatory dysfunction is a major cause of myocardial ischemia that influences the outcomes of patients with coronary artery disease. The mechanisms of coronary microcirculatory dysfunction are heterogeneous and may result from a spectrum of biological and cardiovascular risk factors that may affect also the microcirculation of other vital organs. Microcirculatory dysfunction of the brain, known as cerebral small vessel disease, is increasingly being recognized as a cause of cognitive decline and neurodegenerative disorders...
April 20, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29687016/dietary-patterns-and-physical-activity-correlate-with-total-cholesterol-independently-of-lipid-lowering-drugs-and-antiretroviral-therapy-in-aging-people-living-with-human-immunodeficiency-virus
#10
Alex Marzel, Roger D Kouyos, Sara Reinschmidt, Katharina Balzer, Fabienne Garon, Monica Spitaleri, Nicolas Matthes, Paolo Suter, Rainer Weber, Cornelia Staehelin, Thanh Doco Lecompte, Philip Tarr, Helen Kovari
Background: Hypercholesterolemia is a well established risk factor for coronary heart disease and is highly prevalent among human immunodeficiency virus (HIV)-positive persons. Antiretroviral therapy (ART) can both directly modify total cholesterol and have drug-drug interactions with statins. This makes investigating modifiable behavioral predictors of total cholesterol a pertinent task. Methods: To explore the association between diet and physical activity with cross-sectionally measured total cholesterol, we administered a validated Food-Frequency-Questionnaire to participants of the Swiss HIV Cohort Study ≥45 years old...
April 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29686789/a-case-of-spontaneous-coronary-artery-dissection-presenting-with-acute-anterior-wall-myocardial-infarction-in-a-young-adult-male-an-increasingly-recognized-rare-disease
#11
Mohamed Taha, Htun Latt, Jaafar Al-Khafaji, Mohamed Ali, Richard Seher
Background : Spontaneous coronary artery dissection (SCAD) is increasingly recognized as an important cause of myocardial infarction and sudden death. Although some correlations have been noted in relation to aetiology, no direct causes have been identified in a large number of patients. Most of the patients are women in peripartum period or of childbearing age, with few if any risk factors for coronary heart disease. In men, however, risk factors for atherosclerosis are more prevalent in cases of SCAD Case report : We report a case of a 43-years-old healthy male, with no known risk factors, who presented with ischemic chest pain and elevated troponin levels...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29686252/micro-rnas-from-dna-viruses-are-found-widely-in-plasma-in-a-large-observational-human-population
#12
Milka Koupenova, Eric Mick, Heather A Corkrey, Tianxiao Huan, Lauren Clancy, Ravi Shah, Emelia J Benjamin, Daniel Levy, Evelyn A Kurt-Jones, Kahraman Tanriverdi, Jane E Freedman
Viral infections associate with disease risk and select families of viruses encode miRNAs that control an efficient viral cycle. The association of viral miRNA expression with disease in a large human population has not been previously explored. We sequenced plasma RNA from 40 participants of the Framingham Heart Study (FHS, Offspring Cohort, Visit 8) and identified 3 viral miRNAs from 3 different human Herpesviridae. These miRNAs were mostly related to viral latency and have not been previously detected in human plasma...
April 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29686027/10-year-associations-between-tumor-necrosis-factor-receptors-1-and-2-and-cardiovascular-events-in-patients-with-stable-coronary-heart-disease-a-claricor-effect-of-clarithromycin-on-mortality-and-morbidity-in-patients-with-ischemic-heart-disease-trial-substudy
#13
Axel C Carlsson, Toralph Ruge, Erik Kjøller, Jørgen Hilden, Hans Jørn Kolmos, Ahmad Sajadieh, Jens Kastrup, Gorm Boje Jensen, Anders Larsson, Christoph Nowak, Janus Christian Jakobsen, Per Winkel, Christian Gluud, Johan Ärnlöv
BACKGROUND: We aimed to assess the associations and predictive powers between the soluble receptors for tumor necrosis factor (TNF)-α (TNFR1 and TNFR2) and cardiovascular outcomes in patients with stable coronary heart disease. METHODS AND RESULTS: CLARICOR (Effect of Clarithromycin on Mortality and Morbidity in Patients With Ischemic Heart Disease) is a randomized clinical trial comparing clarithromycin with placebo in patients with stable coronary heart disease...
April 23, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29685826/inuit-country-food-diet-pattern-is-associated-with-lower-risk-of-coronary-heart-disease
#14
Xue Feng Hu, Tiff-Annie Kenny, Hing Man Chan
BACKGROUND: Inuit have experienced a rapid transition in diet and lifestyle over the past several decades, paralleled by the emergence of chronic diseases such as obesity, diabetes, and hypertension. OBJECTIVE: To identify contemporary dietary patterns among Inuit and investigate their association with cardiovascular disease outcomes. DESIGN: This was an association study in a cross-sectional population health and nutrition survey. PARTICIPANTS: The participants included 1,570 adults (aged ≥18 years) from Nunavut in the International Polar Year Inuit Health Survey 2007-2008 who completed diet/health questionnaires and provided blood samples...
April 20, 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29685716/homocysteine-and-incident-atrial-fibrillation-the-atherosclerosis-risk-in-communities-study-and-the-multi-ethnic-study-of-atherosclerosis
#15
Yasuhiko Kubota, Alvaro Alonso, Susan R Heckbert, Faye L Norby, Aaron R Folsom
BACKGROUND: Although many studies have investigated the association of blood homocysteine with major cardiovascular diseases such as coronary heart disease and stroke, research on its association with atrial fibrillation (AF) is scarce. METHODS: We analysed data from Atherosclerosis Risk in Communities (ARIC) Study (n=492, age 45-64 years) and Multi-Ethnic Study of Atherosclerosis (MESA) (n=6,641, age 45-84 years). RESULTS: During the 10,106 and 67,613 person-years of follow-up, we identified 85 and 351 AF events in ARIC and MESA, respectively...
March 21, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29685572/risk-factors-and-trends-in-incidence-of-heart-failure-following-acute-myocardial-infarction
#16
Jennifer Wellings, John B Kostis, Davit Sargsyan, Javier Cabrera, William J Kostis
Patients who develop heart failure (HF) after an acute myocardial infarction (AMI) are at higher risk of adverse fatal and nonfatal outcomes. Published studies on the incidence and associations of HF after infarction have been contradictory, with some reporting increasing and others decreasing incidence. Between 2000 and 2015, 109,717 patients admitted for a first AMI in New Jersey were discharged alive. In the 15 years from 2000 to 2015, the rates of admission for HF in AMI patients who were discharged alive decreased by 60%, from 3...
March 28, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29685202/correlation-between-immunological-inflammatory-markers-and-endothelial-disfunction-in-the-early-stage-of-coronary-heart-disease
#17
Viktor Persic, Ana Lanca Bastiancic, Ivan Rosovic, Damir Raljevic, Dijana Travica Samsa, Luka Bastiancic, Rajko Miskulin, Marko Boban, Gordana Laskarin
Classical risk factors for endothelial dysfunction (ED), such as age, gender, total cholesterol, high-density lipoprotein cholesterol, systolic blood pressure, and smoking history are utilised for the Framingham score and Systemic Coronary Risk Estimation (SCORE) for evaluation of the 10-year cardiovascular risk in routine practice. Nonetheless, pro-inflammatory mediators are deeply involved in the initiation and the progression of ED and coronary artery disease (CAD), and act additionally or independently of metabolic factors before clinical manifestations of the disease appear...
June 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29684595/apelin-and-elabela-toddler-double-ligands-for-apj-apelin-receptor-in-heart-development-physiology-and-pathology
#18
Keiji Kuba, Teruki Sato, Yumiko Imai, Tomokazu Yamaguchi
Apelin is an endogenous peptide ligand for the G protein-coupled receptor APJ/AGTRL1/APLNR and is widely expressed throughout human body. In adult hearts Apelin-APJ/Apelin receptor axis is potently inotropic, vasodilatory, and pro-angiogenic and thereby contributes to maintaining homeostasis in normal and pathological hearts. Apelin-APJ/Apelin receptor is also involved in heart development including endoderm differentiation, heart morphogenesis, and coronary vascular formation. APJ/Apelin receptor had been originally identified as an orphan receptor for its sequence similarity to Angiotensin II type 1 receptor, and it was later deorphanized by identification of Apelin in 1998...
April 20, 2018: Peptides
https://www.readbyqxmd.com/read/29684291/short-term-prediction-of-coronary-heart-disease-mortality-in-the-czech-republic-based-on-data-from-1968-2014
#19
Jindra Reissigová, Miroslav Zvolský
OBJECTIVES: The aim was to explore the patterns of the coronary heart disease (CHD) mortality rates over the past almost 50 years (1968-2014) in the Czech Republic, and to predict the mortality rates in 2015-2019. METHODS: The number of deaths from CHD and the population size were stratified by sex and age. The mortality rates were age-standardized to European population. Their values in 2015-2019 were estimated using the joinpoint log-linear regression, local log-linear regression and negative binomial log-linear regression, separately for males and females...
March 2018: Central European Journal of Public Health
https://www.readbyqxmd.com/read/29683098/untargeted-metabolomics-in-the-discovery-of-novel-biomarkers-and-therapeutic-targets-for-atherosclerotic-cardiovascular-diseases
#20
Vi T Dang, Aric Huang, Geoff H Werstuck
Cardiovascular disease (CVD) is the leading cause of mortality and morbidity worldwide. Four out of five CVD deaths are due to myocardial infarction or stroke. Despite many initiatives that have been established for CVD prevention and risk management, and new therapies to treat existing CVD, patients continue to die from cardiac events. Clearly, we need to identify new therapeutic targets and strategies. Early diagnosis of CVDs and identification of patients at high risk of developing adverse events would allow for timely intervention that prevents serious consequences or death...
April 20, 2018: Cardiovascular & Hematological Disorders Drug Targets
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