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https://www.readbyqxmd.com/read/28723696/advanced-glycation-end-products-downregulate-hoxa9ec-through-activation-of-nuclear-factor-kappa-b-by-reciprocal-interaction
#1
Qian-Qian Zhu, Dong-Lin Li, Yang-Yan He, Zi-Heng Wu, Lu Tian, Cheng-Fei Zheng, Nan Zhang, Hong-Kun Zhang
Advanced glycation end-products (AGEs) have been recognized as an important pathophysiological mechanism in endothelial dysfunction during diabetic atherogenesis. Homeobox (Hox) genes have been identified as playing a regulatory role in the adult cardiovascular system. Regulation of HoxA9EC is involved in diabetic endothelial dysfunction, but the mechanism of HoxA9EC regulation has remained undefined. Here, we sought to investigate how HoxA9EC is regulated in AGE-induced endothelial dysfunction and to explore the mechanism involved...
July 20, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28721160/genetic-disruption-of-multidrug-resistance-associated-protein-1-improves-endothelial-function-and-attenuates-atherosclerosis-in-mrp1-ldlr-double-knockout-mice
#2
Julian Jehle, Cornelius F H Müller, Adem Aksoy, Sebastian Zimmer, Georg Nickenig, Vedat Tiyerili
INTRODUCTION: Multidrug resistance-associated protein 1 (MRP1) is an anion transporter which is implicated in the efflux of the intracellular antioxidant anion glutathione as well as leukotrienes. Pharmacological inhibition of MRP1 exhibits antioxidative and anti-atherosclerotic effects both in vitro and in vivo. However, pharmacological inhibitors of MRP1 lack selectivity, which prompted us to study the in vivo impact of a genetic disruption of MRP1 on endothelial dysfunction, reactive oxygen species formation and atherogenesis in an atherosclerotic mouse model...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28713911/glucagon-like-peptide-1-analogue-liraglutide-ameliorates-atherogenesis-via-inhibiting-advanced-glycation-end-product-induced-receptor-for-advanced-glycosylation-end-product-expression-in-apolipoprotein-e-deficient-mice
#3
Peicheng Li, Zhaosheng Tang, Lin Wang, Bo Feng
Glucagon-like peptide-1 (GLP-1) can protect arteriosclerotic lesions in apolipoprotein-E deficient (ApoE-/-) mice. Advanced glycation end products (AGEs)/receptor for advanced glycation end products (RAGE) interaction serves a key role in the development of diabetic vascular complications. The present study examined whether the GLP-1 analogue liraglutide can ameliorate atherogenesis via inhibiting AGEs-induced RAGE expression. Male ApoE-/- mice (age, 10 weeks) were divided into control, GLP-1, AGEs and AGEs+GLP-1 group...
July 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28711866/identification-of-apob-100-peptide-specific-cd8-t-cells-in-atherosclerosis
#4
Paul C Dimayuga, Xiaoning Zhao, Juliana Yano, Wai Man Lio, Jianchang Zhou, Peter M Mihailovic, Bojan Cercek, Prediman K Shah, Kuang-Yuh Chyu
BACKGROUND: T cells are found in atherosclerotic plaques, with evidence supporting a potential role for CD8+ T cells in atherogenesis. Prior studies provide evidence of low-density lipoprotein and apoB-100 reactive T cells, yet specific epitopes relevant to the disease remain to be defined. The current study was undertaken to identify and characterize endogenous, antigen-specific CD8+ T cells in atherosclerosis. METHODS AND RESULTS: A peptide fragment of apoB-100 that tested positive for binding to the mouse MHC-I allele H2K(b) was used to generate a fluorescent-labeled H2K(b) pentamer and tested in apoE(-/-) mice...
July 15, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28703797/dickkopf1-destabilizes-atherosclerotic-plaques-and-promotes-plaque-formation-by-inducing-apoptosis-of-endothelial-cells-through-activation-of-er-stress
#5
Mingxue Di, Lin Wang, Mengmeng Li, Yu Zhang, Xinxin Liu, Renya Zeng, Han Wang, Yifei Chen, Weijia Chen, Yun Zhang, Mei Zhang
Several clinical studies reported that Dickkopf1 (DKK1) plasma levels are correlated with atherosclerosis. However, the impact of DKK1 on the formation and vulnerability of atherosclerotic plaques remains elusive. This study investigated DKK1's effects on enlargement and destabilization of plaques by targeting endothelial cells and assessing the possible cellular mechanisms involved. The effects of DKK1 on atherogenesis and plaque stability were evaluated in ApoE-/- mice using lentivirus injections to knockdown and knock-in the DKK1 gene...
July 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28697993/dipeptidyl-peptidase-iv-inhibitors-as-novel-regulators-of-vascular-disease
#6
REVIEW
Ioannis Akoumianakis, Charalambos Antoniades
Dipeptidyl peptidase IV (DPP-IV) has been revealed as an adipokine with potential relevance in cardiovascular disease (CVD), while clinically used DPP-IV inhibitors have demonstrated beneficial cardiovascular effects in several experimental studies. Perivascular adipose tissue (PVAT) is a unique adipose tissue depot in close anatomical proximity and bidirectional functional interaction with the vascular wall, which is a source of DPP-IV and its biology may be influenced by DPP-IV inhibition. Recently, DPP-IV inhibition has been associated with decreased local inflammation and oxidative stress both in the vascular wall and the PVAT, potentially regulating atherogenesis progression in vivo...
July 8, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/28692940/betulinic-acid-and-fluvastatin-exhibits-synergistic-effect-on-toll-like-receptor-4-mediated-anti-atherogenic-mechanism-in-type-ii-collagen-induced-arthritis
#7
Limi Elizabeth Mathew, Vrinda Rajagopal, Helen A
Cardiovascular disease (CVD) is a major problem during rheumatoid arthritis which leads to morbidity and mortality in arthritic patients. So the present study emphasizes combinatorial effect of Betulinic acid, a triterpenoid and fluvastatin, an HMG CoA reductase inhibitor on atherogenesis during arthritis. Arthritis was induced by bovine type II collagen dissolved in 0.01M acetic acid at a concentration of 4mg/mL and emulsified in equal volume of incomplete Freund's adjuvant. Betulinic acid (2mg/kg) and fluvastatin (5mg/kg) alone and in combination was administered orally from day 14 to 60...
July 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28688762/thioredoxin-attenuates-oxidized-low-density-lipoprotein-induced-oxidative-stress-in-human-umbilical-vein-endothelial-cells-by-reducing-nadph-oxidase-activity
#8
Beidong Chen, Li Meng, Tao Shen, Huan Gong, Ruomei Qi, Yanyang Zhao, Jie Sun, Li Bao, Gexin Zhao
Oxidative stress is recognized as one of the most important contributing factors to the development of atherosclerosis. Oxidized low-density lipoprotein (ox-LDL) can induce vascular reactive oxygen species (ROS) production, trigger endothelial dysfunction and initiate the progression of atherosclerosis. Previous studies have demonstrated that thioredoxin-1 (Trx) is one of the key regulators of intracellular redox, which is pivotal in atherogenesis. However, the regulation mechanism is still unclear. In this study, we investigated the effects of Trx1 on NADPH oxidase in human umbilical vein endothelial cells (HUVECs), whose ROS level is mainly produced by NADPH oxidase, especially Nox4 isoform...
July 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28683566/inhibition-of-mir-92a-suppresses-oxidative-stress-and-improves-endothelial-function-by-upregulating-heme-oxygenase-1-in-db-db-mice
#9
Lingshan Gou, Lei Zhao, Wencong Song, Li Wang, Jian Liu, Hongsong Zhang, Yuhong Huang, Chi Wai Lau, Xiaoqiang Yao, Xiaoyu Tian, Wing Tak Wong, Jiang-Yun Luo, Yu Huang
AIMS: Inhibition of microRNA-92a (miR-92a) is reported to suppress endothelial inflammation and delay atherogenesis. We hypothesize that miR-92a inhibition protects endothelial function through suppressing oxidative stress in diabetic db/db mice. RESULTS: In this study, we found elevated expression of miR-92a in aortic endothelium from db/db mice and in renal arteries from diabetic subjects. Endothelial cells (ECs) exposed to advanced glycation end products (AGEs) and oxidized LDL (oxLDL) express higher level of miR-92a...
July 6, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28677864/cd36-expression-in-peripheral-blood-mononuclear-cells-reflects-the-onset-of-atherosclerosis
#10
Burak Yazgan, Erdi Sozen, Betul Karademir, Seyfettin Ustunsoy, Umit Ince, Neven Zarkovic, Nesrin Kartal Ozer
Together with complex genetic and environmental factors, increased serum cholesterol and ox-LDL levels are considered as major triggering factors of atherosclerosis. Mononuclear cell infiltration to the arterial wall and uptake of ox-LDL, which is facilitated by CD36 receptor through an uncontrolled manner, play a key role in foam cell formation followed by atherogenesis development. The aim of this study was to analyze if CD36 expression in peripheral blood mononuclear cells reflect its aortic tissue level in hypercholesterolemia...
July 5, 2017: BioFactors
https://www.readbyqxmd.com/read/28677113/plasma-chitotriosidase-and-carotid-intima-media-thickness-in-children-with-sickle-cell-disease
#11
Normeen A Kaddah, Dalia A Saied, Hanan A Alwakeel, Rania H Hashem, Sara M Rowizak, Mohamed A Elmonem
The relationship between chronic hemolysis with subsequent iron overload, inflammation, and premature atherosclerosis has been documented in hemolytic anemias, particularly β-thalassemia. However, no such relationship has been established in sickle cell disease (SCD). We sought to evaluate SCD as a risk factor for early vascular insult by measuring carotid intima-media thickness (CIMT) and plasma chitotriosidase and to assess the role of the latter as a potential quantitative indicator of vascular inflammation and atherogenesis...
July 4, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28674324/flow-mediated-dilatation-as-a-biomarker-in-vascular-surgery-research
#12
Kirthi Bellamkonda, Matthew Williams, Ashok Handa, Regent Lee
Endothelial dysfunction is one of the hallmarks of atherogenesis, and correlates with many cardiovascular risk factors. One of the features of endothelial dysfunction is the loss of nitric oxide (NO) bioavailability, resulting in derangements in the vasodilatory response of the vessel wall. Flow mediated dilatation (FMD) of the brachial artery is an accepted method for non-invasive assessment of systemic endothelial function. FMD is examined extensively in the context of cardiovascular research, and has been utilised as a routine assessment in large cohorts such as the Framingham Heart Study, Young Finns Study, and Gutenberg Heart Study...
July 1, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28674080/macrophage-deficiency-of-mir-21-promotes-apoptosis-plaque-necrosis-and-vascular-inflammation-during-atherogenesis
#13
Alberto Canfrán-Duque, Noemi Rotllan, Xinbo Zhang, Marta Fernández-Fuertes, Cristina Ramírez-Hidalgo, Elisa Araldi, Lidia Daimiel, Rebeca Busto, Carlos Fernández-Hernando, Yajaira Suárez
Atherosclerosis, the major cause of cardiovascular disease, is a chronic inflammatory disease characterized by the accumulation of lipids and inflammatory cells in the artery wall. Aberrant expression of microRNAs has been implicated in the pathophysiological processes underlying the progression of atherosclerosis. Here, we define the contribution of miR-21 in hematopoietic cells during atherogenesis. Interestingly, we found that miR-21 is the most abundant miRNA in macrophages and its absence results in accelerated atherosclerosis, plaque necrosis, and vascular inflammation...
July 3, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28673479/plaque-microvascularization-and-permeability-key-players-in-atherogenesis-and-plaque-rupture
#14
EDITORIAL
Claudia Calcagno, Zahi A Fayad, Paolo Raggi
No abstract text is available yet for this article.
June 21, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28666711/low-high-density-lipoprotein-cholesterol-and-particle-concentrations-are-associated-with-greater-levels-of-endothelial-activation-markers-in-multi-ethnic-study-of-atherosclerosis-participants
#15
Brian T Steffen, Suzette J Bielinski, Paul A Decker, Cecilia Berardi, Nicholas B Larson, James S Pankow, Erin D Michos, Naomi Q Hanson, David M Herrington, Michael Y Tsai
BACKGROUND: High-density lipoproteins (HDL) are well characterized for their role in reverse cholesterol transport but may confer other cardiovascular benefits-specifically, HDL may suppress the endothelial activation cascade in the initiating stages of atherogenesis. OBJECTIVE: It was the primary aim of this study to examine the relations of HDL cholesterol (HDL-C), total HDL particle (HDL-P) concentrations, and HDL-P subclasses with circulating levels of endothelial activation markers in a subcohort of Multi-Ethnic Study of Atherosclerosis participants...
June 13, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28663239/secretory-phospholipase-a2-group-iia-pla2g2a-modulates-insulin-sensitivity-and-metabolism
#16
Michael S Kuefner, Kevin Pham, Jeanna R Redd, Erin J Stephenson, Innocence Harvey, Xiong Deng, Dave Bridges, Eric Boilard, Marshall B Elam, Edwards A Park
Secretory phospholipase A2 group IIA (PLA2G2A) is a member of a family of secretory phospholipases which have been implicated in inflammation, atherogenesis and antibacterial actions. Here, we evaluated the role of PLA2G2A in the metabolic response to a high fat diet. C57BL/6 mice do not express PLA2g2a due to a frameshift mutation. We fed C57BL/6 mice expressing the human PLA2G2A gene (IIA+ mice) a fat diet and assessed the physiologic response. After 10 weeks on the high fat diet, the C57BL/6 mice were obese, but the IIA+ mice did not gain weight or accumulate lipid...
June 29, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28657335/immunometabolic-regulation-of-vascular-redox-state-the-role-of-adipose-tissue
#17
Evangelos K Oikonomou, Charalambos Antoniades
SIGNIFICANCE: Vascular oxidative stress plays a crucial role in atherogenesis and cardiovascular disease (CVD). Recent evidence suggests that vascular redox state is under the control of complex pathophysiological mechanisms, ranging from inflammation to obesity and insulin resistance (IR). Recent advances: Adipose tissue (AT) is now recognized as a dynamic endocrine and paracrine organ that secretes several bioactive molecules, called adipokines. AT has recently been shown to regulate vascular redox state in both an endocrine and a paracrine manner through the secretion of adipokines, therefore providing a mechanistic link for the association between obesity, IR, inflammation and vascular disease...
June 28, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28646220/angiotensin-ii-synergizes-with-baff-to-promote-atheroprotective-regulatory-b-cells
#18
Padmapriya Ponnuswamy, Jeremie Joffre, Olivier Herbin, Bruno Esposito, Ludivine Laurans, Christoph J Binder, Thomas F Tedder, Lynda Zeboudj, Xavier Loyer, Andreas Giraud, Yujiao Zhang, Alain Tedgui, Ziad Mallat, Hafid Ait-Oufella
Angiotensin II (AngII) promotes hypertension, atherogenesis, vascular aneurysm and impairs post-ischemic cardiac remodeling through concerted roles on vascular cells, monocytes and T lymphocytes. However, the role of AngII in B lymphocyte responses is largely unexplored. Here, we show that chronic B cell depletion (Baffr deficiency) significantly reduces atherosclerosis in Apoe (-/-) mice infused with AngII. While adoptive transfer of B cells in Apoe (-/-) /Baffr (-/-) mice reversed atheroprotection in the absence of AngII, infusion of AngII in B cell replenished Apoe (-/-) /Baffr (-/-) mice unexpectedly prevented the progression of atherosclerosis...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28644213/platelet-pathophysiology-pharmacology-and-function-in-coronary-artery-disease
#19
Homam Ibrahim, Neal S Kleiman
Platelets play a key role in the pathophysiology of coronary artery disease and acute coronary syndromes. Our understanding of platelet function in thrombus formation has increased considerably, resulting in the development of clinically effective treatment strategies and identification of new targets. An underappreciated platelet function is their contribution toward acute and chronic inflammatory processes including atherogenesis. In this review, we discuss the role of platelets in atherosclerosis and thrombosis, platelet function testing, and the pharmacology of currently available antiplatelet drugs...
June 21, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28642826/elucidation-of-the-role-of-lectin-like-oxldl-receptor-1-in-the-metabolic-responses-of-macrophages-to-human-oxldl
#20
Danielle W Kimmel, William P Dole, David E Cliffel
Atherogenesis is the narrowing of arteries due to plaque build-up that results in cardiovascular disease that can lead to death. The macrophage lectin-like oxidized LDL receptor-1 (LOX-1), also called the oxidized low-density lipoprotein receptor 1 (OLR1), is currently thought to aid in atherosclerotic disease progression; therefore metabolic studies have potential to both provide mechanistic validation for the role of LOX-1 in disease progression and provide valuable information regarding biomarker strategies and clinical imaging...
2017: Journal of Lipids
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