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https://www.readbyqxmd.com/read/29346374/epidemiological-investigation-into-the-prevalence-of-abnormal-inter-arm-blood-pressure-differences-among-different-ethnicities-in-xinjiang-china
#1
Ling Sun, Ting Zou, Bao-Zhu Wang, Fen Liu, Qing-Hua Yuan, Yi-Tong Ma, Xiang Ma
OBJECTIVES: The prevalence of and risk factors for IAD among different ethnicity groups was unknown. Our aim was to investigate the prevalence of and risk factors for IAD among Han, Uygur and Kazakh ethnicities in Xinjiang. China. METHODS: In total, 14,618 adult participants (7,799 males and 6,819 females) were recruited from the Cardiovascular Risk Survey. A 4-stage stratified cluster random sampling method was used. The participants' personal information and medical history were assessed by questionnaire...
2018: PloS One
https://www.readbyqxmd.com/read/29337706/cholesterol-efflux-in-the-transplant-patient
#2
Sangita Sudharshan, Ali Javaheri
PURPOSE OF REVIEW: Cholesterol metabolism is increasingly recognized in inflammatory diseases including transplantation. This review discusses the mechanistic underpinnings that tie macrophage cholesterol efflux capacity (CEC) of high-density lipoprotein (HDL) to chronic rejection in transplanted patients. RECENT FINDINGS: Animal studies suggest that administration of apolipoprotein A-I, the main protein constituent of HDL, can prevent transplant arteriosclerosis...
January 13, 2018: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/29330517/iron-induced-calcification-in-human-aortic-vascular-smooth-muscle-cells-through-interleukin-24-il-24-with-without-tnf-alpha
#3
Sayuri Kawada, Yasuyuki Nagasawa, Mutsuki Kawabe, Hideki Ohyama, Aritoshi Kida, Nahoko Kato-Kogoe, Masayoshi Nanami, Yukiko Hasuike, Takahiro Kuragano, Hiromitsu Kishimoto, Keiji Nakasho, Takeshi Nakanishi
In CKD patients, arteriosclerotic lesions, including calcification, can occur in vascular smooth muscle cells in a process called Moenckeberg's medial arteriosclerosis. Iron overload induces several complications, including the acceleration of arteriosclerosis. However, the relationship between Moenckeberg's arteriosclerosis in vascular smooth muscle cells and iron accumulation has remained unknown. We tested the accelerated effect of iron on calcification in cultured human aortic vascular smooth muscle cells (HASMCs)...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29323719/the-multifaceted-link-between-inflammation-and-human-diseases
#4
Peramaiyan Rajendran, Ya-Fang Chen, Yu-Feng Chen, Li-Chin Chung, Shanmugam Tamilselvi, Chia-Yao Shen, Cecilia Hsuan Day, Ray-Jade Chen, Vijaya Padma Viswanadha, Wei-Wen Kuo, Chih-Yang Huang
Increasing reports on epidemiological, diagnostic and clinical studies suggest that dysfunction of the inflammatory reaction results in chronic illnesses such as cancer, arthritis, arteriosclerosis, neurological disorders, liver diseases, and renal disorders. Chronic inflammation might progress if injurious agent persists; however, more typically than not, the response is chronic from the start. Distinct to most changes in acute inflammation, chronic inflammation is characterized by the infiltration of damaged tissue by mononuclear cells like macrophages, lymphocytes, and plasma cells, in addition to tissue destruction and attempts to repair...
January 11, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29304538/catestatin-prevents-macrophage-driven-atherosclerosis-but-not-arterial-injury-induced-neointimal-hyperplasia
#5
Miho Kojima, Nana Ozawa, Yusaku Mori, Yui Takahashi, Kaho Watanabe-Kominato, Remina Shirai, Rena Watanabe, Kengo Sato, Taka-Aki Matsuyama, Hatsue Ishibashi-Ueda, Shinji Koba, Youichi Kobayashi, Tsutomu Hirano, Takuya Watanabe
Catestatin, a catecholamine-release inhibitory peptide, has multiple cardiovascular activities. Conflicting results have been recently reported by increased or decreased plasma levels of catestatin in patients with coronary artery disease (CAD). However, there have been no previous reports regarding the effects of catestatin on arteriosclerosis. This study evaluated the vasoprotective effects of catestatin on human macrophages, human aortic smooth muscle cells (HASMCs) and human umbilical vein endothelial cells (HUVECs) in vitro, and aortic atherosclerosis and wire injury-induced femoral artery neointimal hyperplasia in apolipoprotein E-deficient (ApoE-/-) mice fed with a high-cholesterol diet...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29285176/efficacy-of-continuous-positive-airway-pressure-treatment-in-treating-obstructive-sleep-apnea-hypopnea-syndrome-associated-with-carotid-arteriosclerosis
#6
Yong-Qian Jiang, Jin-Shan Xue, Juan Xu, Zhi-Xiang Zhou, You-Lin Ji
Sleep apnea negatively impacts patients' ability to oxygenate the bloodstream during sleep and has far-reaching, deleterious effects. The present study sought to assess the correlation between obstructive sleep apnea hypopnea syndrome (OSAHS), carotid atherosclerosis, and blood pressure variability (BPV), and to evaluate the therapeutic effects of continuous positive airway pressure (CPAP). Patients with OSAHS were classified as mild, moderate, or severe according to their condition and compared with healthy control participants...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29285174/kasabach-merritt-syndrome-combined-with-hypercalcemia-a-case-report
#7
Runying Zou, Fang Peng, Tian Yu, Saizhen Zeng, Yalan You, Keke Chen, Hui Zou, Xin Tian, Chengguang Zhu, Xiangling He
The present case report presented the diagnosis and treatment course of an infant diagnosed with Kasabach-Merritt syndrome (KMS) combined with hypercalcemia (HC). A 35-day-old infant with swelling on the upper right arm for >1 month and thrombocytopenia for 1 day was admitted to Hunan Provincial People's Hospital (Changsha, China) and a series of treatments, including γ-globulin impact, heparin anticoagulation, platelet transfusion, supplement of cryoprecipitate and fibrinogen following heparinization and inhabitation of vascular endothelial cell proliferation by propranolol, were performed...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29282242/arteriosclerosis-thrombosis-and-vascular-biology
#8
(no author information available yet)
No abstract text is available yet for this article.
January 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29282004/pathologic-analysis-of-non-neoplastic-parenchyma-in-renal-cell-carcinoma-a-comprehensive-observation-in-radical-nephrectomy-specimens
#9
Xun Wang, Qiang Liu, Wen Kong, Jiwei Huang, Yonghui Chen, Yiran Huang, Jin Zhang
BACKGROUND: This study provides a comprehensive examination of the histological features of non-neoplastic parenchyma in renal cell carcinoma (RCC). We prospectively collected radical nephrectomy (RN) specimens, to analyze the histological changes within peritumoral and distant parenchyma. METHODS: Data of patients who underwent RN and had no known history of diabetes, hypertension, hyperlipidemia, or chronic kidney disease etc., were prospectively collected. Tumor pseudo-capsule (PC), and parenchyma within 2 cm from tumor margin, were pathologically assessed...
December 28, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29281178/a-novel-anti-hypertensive-peptide-identified-in-thermolysin-digested-rice-bran
#10
Naohisa Shobako, Yutaro Ogawa, Atsushi Ishikado, Kayo Harada, Etsuko Kobayashi, Hirohisa Suido, Takeshi Kusakari, Mariko Maeda, Makoto Suwa, Motonobu Matsumoto, Ryuhei Kanamoto, Kousaku Ohinata
SCOPE: Hypertension is a risk factor for arteriosclerosis. In this study, we investigated the anti-hypertensive effect of protease-digested rice bran in a spontaneously hypertension rat (SHR) model. We also purified a novel anti-hypertensive peptide from the digest. METHODS AND RESULTS: Thermolysin-digested rice bran (TRB) was administered to SHRs for 4 weeks, and systolic blood pressure (SBP) was measured weekly using the tail-cuff method. TRB showed an anti-hypertensive effect in a dose-dependent manner...
December 27, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29277639/contact-kallikrein-kinin-system-activation-in-whole-human-blood-induced-by-low-concentrations-of-%C3%AE-fe2o3-nanoparticles
#11
Kristina N Ekdahl, Padideh Davoodpour, Barbro Ekstrand-Hammarström, Karin Fromell, Osama A Hamad, Jaan Hong, Anders Bucht, Camilla Mohlin, Gulaim A Seisenbaeva, Vadim G Kessler, Bo Nilsson
Iron-oxide nanoparticles (NPs) generated by environmental events are likely to represent health problems. α-Fe2O3 NPs were synthesized, characterized and tested in a model for toxicity utilizing human whole blood without added anticoagulant. MALDI-TOF of the corona was performed and activation markers for plasma cascade systems (complement, contact and coagulation systems), platelet consumption and release of growth factors, MPO, and chemokine/cytokines from blood cells were analyzed. The coronas formed on the pristine α-Fe2O3 NPs contained contact system proteins and they induced massive activation of the contact (kinin/kallikrein) system, as well as thrombin generation, platelet activation, and release of two pro-angiogeneic growth factors: platelet-derived growth factor and vascular endothelial growth factor, whereas complement activation was unaffected...
December 22, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29273332/global-glomerulosclerosis-with-nephrotic-syndrome-the-clinical-importance-of-age%C3%A2-adjustment
#12
Musab S Hommos, Caihong Zeng, Zhihong Liu, Jonathan P Troost, Avi Z Rosenberg, Matthew Palmer, Walter K Kremers, Lynn D Cornell, Fernando C Fervenza, Laura Barisoni, Andrew D Rule
Globally sclerotic glomeruli (GSG) occur with both normal aging and kidney disease. However, it is unknown whether any GSG or only GSG exceeding that expected for age is clinically important. To evaluate this, we identified patients with a glomerulopathy that often presents with nephrotic syndrome (focal segmental glomerulosclerosis, membranous nephropathy, or minimal change disease) in the setting of the Nephrotic Syndrome Study Network (NEPTUNE), China-Digital Kidney Pathology (DiKiP), and the Southeast Minnesota cohorts...
December 19, 2017: Kidney International
https://www.readbyqxmd.com/read/29250671/correlation-between-leptin-and-ghrelin-expression-in-adipose-visceral-tissue-and-clinical-biological-features-in-malignant-obesity
#13
Gabriel Verdeş, Ciprian Constantin DuŢă, Roxana Popescu, Mihai MituleŢu, Sorin Ursoniu, Octavian Fulger Lazăr
Morbid obesity is a metabolic disease characterized by an excessive accumulation of adipose tissue (=40%). This disorder is commonly associated with cardiovascular disease, arteriosclerosis, type 2 diabetes, hypothyroidism and some types of cancer. The most common metabolic signals associated with the disease are leptin, ghrelin, with antagonic effects. Our study aimed at highlighting leptin and ghrelin expression levels, as well as establishing correlations between them and clinical-biological parameters in obese patients...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29249336/pulsatile-flow-of-non-newtonian-blood-fluid-inside-stenosed-arteries-investigating-the-effects-of-viscoelastic-and-elastic-walls-arteriosclerosis-and-polycythemia-diseases
#14
A Abbas Nejad, Z Talebi, D Cheraghali, A Shahbani-Zahiri, M Norouzi
BACKGROUND AND OBJECTIVE: In this study, the interaction of pulsatile blood flow with the viscoelastic walls of the axisymmetric artery is numerically investigated for different severities of stenosis. The geometry of artery is modeled by an axisymmetric cylindrical tube with a symmetric stenosis in a two-dimensional case. The effects of stenosis severity on the axial velocity profile, pressure distribution, streamlines, wall shear stress, and wall radial displacement for the viscoelastic artery are also compared to the elastics artery...
February 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29239204/john-hunter-s-operation-for-popliteal-aneurysm
#15
Harold Ellis
An aneurysm is defined as a "sac communicating with the lumen of an artery" and the treatment of the various types of this disease has intrigued surgeons through the ages. Aneurysms of the popliteal artery today are fairly uncommon. However, in the 18th century they were quite frequently encountered, many of them in coach drivers. We can only surmise that this was the result of repetitive trauma to the artery, already the seat of arteriosclerosis, against the rim at the top of the long leather riding boot which was worn at that time...
June 2017: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29232311/lithium-colchicine-a-potential-strategy-to-reduce-pro-inflammatory-effects-of-lithium-treatment
#16
John J Mooney, Roscoe O Brady
PURPOSE: Rosenblat and McIntyre (Acta Psychiatr Scand. 2015;132: 180-191) propose that immune disorders are important mediators between bipolar disorders and medical comorbidities. Rosenblat et al (Bipolar Disord. 2016;18:89-101) present a meta-analysis showing that adjunctive anti-inflammatory agents could evoke moderate antidepressant responses in bipolar disorders. We propose using the anti-inflammatory drug colchicine to improve the long-term safety and efficacy of lithium treatment for bipolar disorders...
February 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29227572/factors-associated-with-serum-magnesium-and-vascular-stiffness-in-maintenance-hemodialysis-patients
#17
Mai Yorifuji, Takahiro Kuragano, Sayuri Kawada, Wataru Fukao, Kazuhiro Toyoda, Takeshi Nakanishi
INTRODUCTION: We evaluated the associated factors of serum magnesium in patients on maintenance hemodialysis (MHD). Furthermore, we evaluated the relationship between low serum magnesium and arteriosclerosis in these patients. METHODS: In 129 patients on MHD, we evaluated the blood levels of magnesium, brachial-ankle pulse wave velocity (ba-PWV), ankle-brachial index (ABI), and intima-media thickness of the common carotid artery (IMT). FINDINGS: In MHD patients, the serum level of magnesium was significantly correlated with age, calcium, TNF-α, albumin, and ba-PWV but not with ABI or IMT...
December 11, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/29218089/the-role-of-sildenafil-in-the-development-of-transplant-arteriosclerosis-in-rat-aortic-grafts
#18
Shuai Luo, Mei Yang, Hao Jin, Zi-Qiang Xu, Yi-Fu Li, Peng Xia, Yi-Rrong Yang, Bi-Cheng Chen, Yan Zhang
Chronic rejection (CR), which is characterized histologically by progressive graft arteriosclerosis, remains a significant barrier to the long-term survival of a graft. Sildenafil has been shown to protect vascular endothelial cells. In this study, we found that sildenafil significantly reduces the thickness of transplant vascular intima in a rat aortic transplant model. Moreover, sildenafil dramatically decreased the expression of transforming growth factor-β1 (TGF-β1), vascular endothelial growth factor (VEGF), and α-smooth muscle actin (α-SMA) in the grafted aortas and increased the concentrations of cyclic guanosine monophosphate (cGMP) and endothelial nitric oxide synthase (eNOS) in serum...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29200667/davallia-mariesii-moore-improves-fc%C3%AE%C2%B5ri-mediated-allergic-responses-in-the-rat-basophilic-leukemia-mast-cell-line-rbl-2h3-and-passive-cutaneous-anaphylaxis-in-mice
#19
Hyun Ju Do, Tae Woo Oh, Ju Hye Yang, Kwang Il Park, Jin Yeul Ma
Davallia mariesii Moore (Drynaria rhizome extract (DRE)) is widely known for its efficacy in treating inflammation, arteriosclerosis, and bone injuries. This study evaluated whether treatment with DRE inhibited FcɛRI-mediated allergic responses in the RBL-2H3 mast cells and investigated the early- and late-phase mechanisms by which DRE exerts its antiallergic effects. IgE anti-DNP/DNP-HSA-sensitized RBL-2H3 mast cells were tested for cytotoxicity to DRE, followed by the assessment of β-hexosaminidase release...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29197945/spontaneous-expulsive-suprachoroidal-haemorrhage-in-an-asymptomatic-elderly-patient-a-case-report
#20
Jacqueline Ting Yl, Humayun Akhter Faisal, Shin Wei Pan
PURPOSE: To describe a rare case of spontaneous expulsive suprachoroidal haemorrhage (SESCH) in an asymptomatic elderly patient. METHOD: This is a case report of a 76-year-old Chinese female, presented as an emergency with spontaneous left eye bleeding. She had underlying uncontrolled hypertension, no other systemic illness and not on anticoagulant. She has a history of right eye cataract operation, right eye angle-closure glaucoma and left eye absolute glaucoma complicated with painless left blind eye...
December 2, 2017: International Ophthalmology
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