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https://www.readbyqxmd.com/read/28515939/vaccine-against-arteriosclerosis-an-update
#1
REVIEW
Kuang-Yuh Chyu, Paul C Dimayuga, Prediman K Shah
Substantial data from experimental and clinical investigation support the role of immune-mediated mechanisms in atherogenesis, with immune systems responding to many endogenous and exogenous antigens that play either proatherogenic or atheroprotective roles. An active immunization strategy against many of these antigens could potentially alter the natural history of atherosclerosis. This review mainly focuses on the important studies on the search for antigens that have been tested in vaccine formulations to reduce atherosclerosis in preclinical models...
April 2017: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/28499804/monckeberg-arteriosclerosis-a%C3%A2-telltale%C3%A2-sign
#2
Galal Omami
Monckeberg arteriosclerosis is often an incidental finding recognized at plain radiography. It differs from the more common atherosclerosis in that the tunica intima remains unaffected; hence, the vessel lumen is preserved. Monckeberg arteriosclerosis is most commonly seen in patients with diabetes and patients with end-stage renal disease. In this short communication, the author presents a rare case of Monckeberg arteriosclerosis affecting the facial vasculature.
April 14, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28486272/blood-pressure-heart-rate-and-double-product-in-a-pooled-cohort-the-japan-arteriosclerosis-longitudinal-study
#3
Kei Asayama, Atsushi Hozawa, Masataka Taguri, Takayoshi Ohkubo, Yasuharu Tabara, Kazuo Suzuki, Takashi Ando, Akiko Harada, Yasuo Ohashi, Hirotsugu Uechima, Hideaki Toyoshima, Yutaka Imai
OBJECTIVE: To identify the characteristics of blood pressure (BP), heart rate (HR), and double product in a Japanese population sample. METHODS: We pooled individual records from 1999 to 2005 for 111 007 participants in 25 community-based cohorts and seven worksite-based cohorts. The data were analyzed to provide information on BP, HR, and double product according to age-sex groups and use of antihypertensive medication. RESULTS: Average BP was 130/77 mmHg among men and women combined...
May 8, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28480636/the-relationship-between-neutrophil-to-lymphocyte-ratio-and-artery-stiffness-in-subtypes-of-hypertension
#4
Huan Wang, Yuanhui Hu, Yanting Geng, Huaqin Wu, Yuguang Chu, Ruihua Liu, Yi Wei, Zhiling Qiu
Recently, neutrophil/lymphocyte ratio (NLR) has been proved to be a useful indicator of inflammation and cardiovascular risk. Brachial-ankle pulse wave velocity is an indicator for early atherosclerotic changes. It is unknown whether NLR differs in subtypes of hypertension, and little research has been performed on the relationship between NLR and arteriosclerosis in subtypes of hypertension. The purpose of this article was to investigate their relationship. A total of 217 consecutive patients with hypertension and 132 persons without hypertension were included...
May 7, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28477383/screening-free-radical-scavengers-in-xiexin-tang-by-hplc-abts-dad-q-tof-ms
#5
Yu-Qing Wang, Shu-Jiao Li, Guo Zhuang, Rong-Hui Geng, Xu Jiang
Xiexin Tang (XXT) is a traditional Chinese medicine (TCM) that has been used in herbal clinics for more than 1800 years. Many studies have shown that XXT has therapeutic effects on patients with arteriosclerosis (AS) owing to its antioxidant activity. However, there is little information about the relationship between the chemical composition of XXT and its antioxidant activity. In this study, the HPLC-ABTS-DAD-Q-TOF/MS method, which can simultaneously identify individual components and rapidly screen for antioxidant compounds, was used to screen and identify antioxidant components in XXT...
May 6, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28474128/-chronic-hypoxia-and-cardiovascular-risk-clinical-significance-of-different-forms-of-hypoxia
#6
REVIEW
U Koehler, O Hildebrandt, J Krönig, W Grimm, J Otto, W Hildebrandt, R Kinscherf
It is of fundamental importance to differentiate whether chronic hypoxia occurs intermittently or persistently. While chronic intermittent hypoxia (CIH) is found typically in patients with obstructive sleep apnea (OAS), chronic persistent hypoxia (CPH) is typically diagnosed in patients with chronic lung disease. Cardiovascular risk is markedly increased in patients with CIH compared to patients with CPH. The frequent change between oxygen desaturation and reoxygenation in patients with CIH is associated with increased hypoxic stress, increased systemic inflammation, and enhanced adrenergic activation followed by endothelial dysfunction and increased arteriosclerosis...
May 4, 2017: Herz
https://www.readbyqxmd.com/read/28467197/difference-in-bilateral-digital-volume-pulse-as-a-novel-non-invasive-approach-to-assessing-arteriosclerosis-in-aged-and-diabetic-subjects-a-preliminary-study
#7
Hsien-Tsai Wu, Kuan-Wei Lee, Wen-Yao Pan, An-Bang Liu, Cheuk-Kwan Sun
OBJECTIVE: This study aimed at validating photoplethysmography for assessing bilateral blood pressure differences through investigating the correlations of digital volume pulse with arteriosclerosis risk. METHODS: Totally, 111 subjects (70 healthy and 41 diabetic) were recruited. Demographic, blood pressure and anthropometric data were recorded. Blood was collected for determining serum cholesterol, total triglyceride, total cholesterol, high-/low-density lipoprotein cholesterol, fasting blood sugar and glycated haemoglobin concentrations...
May 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28466409/effects-of-pitavastatin-on-walking-capacity-and-cd34-133-cell-number-in-patients-with-peripheral-artery-disease
#8
Kenshiro Arao, Takanori Yasu, Yasuhiro Endo, Toshikazu Funazaki, Yoshimi Ota, Kazunori Shimada, Eiichi Tokutake, Naoki Naito, Bonpei Takase, Minoru Wake, Nahoko Ikeda, Yasuto Horie, Hiroyuki Sugimura, Shin-Ichi Momomura, Masanobu Kawakami
This multi-center prospective non-randomized comparative study investigated the effects of pitavastatin in patients with peripheral artery disease (PAD) in terms of exercise tolerance capacities and peripheral CD34(+)/133(+) cell numbers. At baseline, a peripheral blood test was administered to 75 patients with PAD, along with a treadmill exercise test using the Skinner-Gardner protocol to measure asymptomatic walking distance (AWD) and maximum walking distance (MWD). Each patient was assigned to a 6-month pitavastatin treatment group (n = 53) or a control group (n = 22), according to the patient's preference...
May 2, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28465133/jcl-roundtable-future-of-the-lipid-laboratory-choosing-valuable-measures-among-the-lipoproteins-part-1
#9
REVIEW
William Virgil Brown, Yehuda Handelsman, Seth S Martin, Pamela B Morris
The measurement of cholesterol and triglycerides as indicators of metabolic disorders and most particularly of vascular disease risk has been of growing importance to physicians and epidemiologists over the past century. This was refocused on the lipoproteins, the specific packages in blood that carry these lipids, by John Gofman, MD, PhD, and Don Fredrickson, MD, more than 50 years ago. We continue to learn about the metabolism of these large molecular structures and their relationship to arteriosclerosis as new genetic and interventional studies are published...
April 21, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28463213/-relation-between-severity-of-atherosclerosis-and-progression-of-renal-disease-in-nephrectomized-patients
#10
Enrique Dorado, María V Mouesca, Marina Khoury, Diego Barreiro, Norberto Lafós, Silvia Rausch
Radical nephrectomy is associated with a progressive decline in renal function. Clinical parameters in post-nephrectomy insufficiency were described but the impact of histopathologic vascular findings in the non-neoplastic kidney of nephrectomy specimen, has been poorly studied. Our aim was to evaluate whether the severity of atherosclerosis in non-neoplastic renal tissue predicts the evolution of glomerular filtration rate in patients undergoing total nephrectomy. Thirty-one non-donor patients with unilateral radical nephrectomy were included...
2017: Medicina
https://www.readbyqxmd.com/read/28460874/risk-index-for-postoperative-acute-kidney-injury-after-valvular-surgery-using-cardiopulmonary-bypass
#11
Takashi Yamauchi, Shigeru Miyagawa, Yasushi Yoshikawa, Koichi Toda, Yoshiki Sawa
BACKGROUND: Acute kidney injury (AKI) after valvular surgical procedures with cardiopulmonary bypass carries potentially high mortality and morbidity rates. This study investigated the risk factors for AKI, and the study investigators developed a risk index to predict postoperative AKI. METHODS: A total of 1,484 consecutive non-dialysis-dependent patients who underwent valvular operations using cardiopulmonary bypass between 2008 and 2011 were retrospectively investigated...
April 28, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28455826/subendocardial-viability-ratio-in-patients-with-rheumatoid-arthritis-comparison-with-healthy-controls-and-identification-of-prognostic-factors
#12
Panagiota Anyfanti, Areti Triantafyllou, Eugenia Gkaliagkousi, Georgios Triantafyllou, Nikolaos Koletsos, Sophia Chatzimichailidou, Panagiotis Panagopoulos, Ioannis Botis, Spyros Aslanidis, Stella Douma
Cardiac involvement is common in rheumatoid arthritis. Subendocardial viability ratio (SEVR) is a non-invasive measure of microvascular coronary perfusion, yet it remains unclear whether it is affected in rheumatoid arthritis patients. We additionally sought predictors of SEVR in rheumatoid arthritis among a wide range of disease-related parameters, cardiac and hemodynamic factors, and markers of atherosclerosis, arteriosclerosis, and endothelial dysfunction. SEVR was estimated in rheumatoid arthritis patients and healthy controls by applanation tonometry, which was also used to evaluate arterial stiffness (pulse wave velocity and augmentation index)...
April 28, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28447751/deep-sea-water-improves-hypercholesterolemia-and-hepatic-lipid-accumulation-through-the-regulation-of-hepatic-lipid-metabolic-gene-expression
#13
Kyu-Shik Lee, So-Young Chun, Yun-Suk Kwon, Soyoung Kim, Kyung-Soo Nam
A high‑fat diet or high‑cholesterol diet (HCD) is a major cause of metabolic diseases, including obesity and diabetes; vascular diseases, including hypertension, stroke and arteriosclerosis; and liver diseases, including hepatic steatosis and cirrhosis. The present study aimed to evaluate the effects of deep sea water (DSW) on rats fed a HCD. DSW decreased HCD‑induced increases in total cholesterol and low‑density lipoprotein (LDL) cholesterol in the blood, and recovered high‑density lipoprotein cholesterol...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28433209/practical-recommendations-for-the-management-of-cardiovascular-risk-associated-with-atherogenic-dyslipidemia-with-special-attention-to-residual-risk-spanish-adaptation-of-a-european-consensus-of-experts
#14
Juan F Ascaso, Roberto Ferrari
This document has discussed clinical approaches to managing cardiovascular risk in clinical practice, with special focus on residual cardiovascular risk associated with lipid abnormalities, especially atherogenic dyslipidaemia (AD). A simplified definition of AD was proposed to enhance understanding of this condition, its prevalence and its impact on cardiovascular risk. AD can be defined by high fasting triglyceride levels (≥2.3mmol/L / ≥200mg/dL) and low high-density lipoprotein cholesterol (HDL-c) levels (≤1,0 / 40 and ≤1,3mmol/L / 50mg/dL in men and women, respectively) in statin-treated patients at high cardiovascular risk...
April 19, 2017: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/28420489/mast-cells-emerge-as-mediators-of-atherosclerosis-special-emphasis-on-il-37-inhibition
#15
REVIEW
Pio Conti, Gianfranco Lessiani, Spyridon K Kritas, Gianpaolo Ronconi, Aessandro Caraffa, Theoharis C Theoharides
In atherosclerosis lipoproteins stimulate the innate immune response, leading to the release of inflammatory cytokines and chemokines. Hypercholesterolemia may activate the synthesis and release of inflammatory cytokines such as IL-1, which induces TNF release in mast cells (MCs). IL-1 and IL-1 family members orchestrate a broadening list of inflammatory diseases, including atherosclerosis. MCs are implicated in the pathophysiology of several diseases including allergy and inflammation. Activated MCs, located perivascularly, contribute to inflammation in atherosclerosis by producing inflammatory cytokines...
April 12, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28416195/pitavastatin-versus-pravastatin-in-adults-with-hiv-1-infection-and-dyslipidaemia-intrepid-12-week-and-52-week-results-of-a-phase-4-multicentre-randomised-double-blind-superiority-trial
#16
Judith A Aberg, Craig A Sponseller, Douglas J Ward, Vladimir A Kryzhanovski, Stuart E Campbell, Melanie A Thompson
BACKGROUND: People living with HIV-1 infection are at greater risk for cardiovascular disease than seronegative adults. Treatment of dyslipidaemia with statins has been challenging in people with HIV because of an increased potential for drug interactions due to competing cytochrome P450 metabolism between statins and commonly used antiretroviral agents. Neither pitavastatin nor pravastatin depend on cytochrome P450 for primary metabolism. We aimed to assess the safety and efficacy of pitavastatin versus pravastatin in adults with HIV and dyslipidaemia...
April 13, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28412018/diffuse-carotid-arteriosclerosis-and-stroke-in-a-patient-with-schimke-immuno-osseous-dysplasia
#17
Debopam Samanta, Raghu Ramakrishnaiah
No abstract text is available yet for this article.
March 23, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28407320/role-of-tlr4-and-mir-155-in-peripheral-blood-mononuclear-cell-mediated-inflammatory-reaction-in-coronary-slow-flow-and-coronary-arteriosclerosis-patients
#18
Jiangyan Huang, Qin Yang, Longmiao He, Jun Huang
BACKGROUND: To study the role of toll-like receptor 4 (TLR4) and MicroRNA-155 (miR-155) in the peripheral blood mononuclear cell (PBMC)-mediated inflammation in coronary slow flow (CSF) and coronary arteriosclerosis. METHODS: Patients were divided into acute coronary syndrome (ACS), stable angina pectoris (SAP), CSF, and healthy control (HC) groups. The isolated PBMCs were treated with lipopolysaccharide (LPS)/and antagomiR-155. TLR4, miR-155, and the concentrations of tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1, and IL-10 were measured...
April 13, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28407281/multiparametric-quantitative-ultrasound-imaging-in-assessment-of-chronic-kidney-disease
#19
Jing Gao, Alan Perlman, Safa Kalache, Nathaniel Berman, Surya Seshan, Steven Salvatore, Lindsey Smith, Natasha Wehrli, Levi Waldron, Hanish Kodali, James Chevalier
OBJECTIVES: To evaluate the value of multiparametric quantitative ultrasound imaging in assessing chronic kidney disease (CKD) using kidney biopsy pathologic findings as reference standards. METHODS: We prospectively measured multiparametric quantitative ultrasound markers with grayscale, spectral Doppler, and acoustic radiation force impulse imaging in 25 patients with CKD before kidney biopsy and 10 healthy volunteers. Based on all pathologic (glomerulosclerosis, interstitial fibrosis/tubular atrophy, arteriosclerosis, and edema) scores, the patients with CKD were classified into mild (no grade 3 and <2 of grade 2) and moderate to severe (at least 2 of grade 2 or 1 of grade 3) CKD groups...
April 13, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28392865/cardio-ankle-vascular-index-and-c-reactive-protein-are-useful-parameters-for-identification-of-ischemic-heart-disease-in-acute-heart-failure-patients
#20
Shunsuke Kiuchi, Shinji Hisatake, Takayuki Kabuki, Takashi Oka, Shintaro Dobashi, Takahiro Fujii, Takanori Ikeda
BACKGROUND: The most common cause of heart failure (HF) is ischemic heart disease (IHD). Evaluation of IHD with non-invasive examinations is useful for the treatment of HF, and cardio-ankle vascular index (CAVI) is a good parameter for detecting systemic arteriosclerosis. However, the relationship between IHD and CAVI in acute HF (AHF) patients is still unclear. Therefore, we investigated the effect of non-invasive examinations, including CAVI to detect IHD. METHODS: We studied 53 consecutive patients (average age of 66...
May 2017: Journal of Clinical Medicine Research
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