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https://www.readbyqxmd.com/read/28420489/mast-cells-emerge-as-mediators-of-atherosclerosis-special-emphasis-on-il-37-inhibition
#1
REVIEW
Pio Conti, Gianfranco Lessiani, Spyridon K Kritas, Gianpaolo Ronconi, Aessandro Caraffa, Theoharis C Theoharides
In atherosclerosis lipoproteins stimulate the innate immune response, leading to the release of inflammatory cytokines and chemokines. Hypercholesterolemia may activate the synthesis and release of inflammatory cytokines such as IL-1, which induces TNF release in mast cells (MCs). IL-1 and IL-1 family members orchestrate a broadening list of inflammatory diseases, including atherosclerosis. MCs are implicated in the pathophysiology of several diseases including allergy and inflammation. Activated MCs, located perivascularly, contribute to inflammation in atherosclerosis by producing inflammatory cytokines...
April 12, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28416195/pitavastatin-versus-pravastatin-in-adults-with-hiv-1-infection-and-dyslipidaemia-intrepid-12-week-and-52-week-results-of-a-phase-4-multicentre-randomised-double-blind-superiority-trial
#2
Judith A Aberg, Craig A Sponseller, Douglas J Ward, Vladimir A Kryzhanovski, Stuart E Campbell, Melanie A Thompson
BACKGROUND: People living with HIV-1 infection are at greater risk for cardiovascular disease than seronegative adults. Treatment of dyslipidaemia with statins has been challenging in people with HIV because of an increased potential for drug interactions due to competing cytochrome P450 metabolism between statins and commonly used antiretroviral agents. Neither pitavastatin nor pravastatin depend on cytochrome P450 for primary metabolism. We aimed to assess the safety and efficacy of pitavastatin versus pravastatin in adults with HIV and dyslipidaemia...
April 13, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28412018/diffuse-carotid-arteriosclerosis-and-stroke-in-a-patient-with-schimke-immuno-osseous-dysplasia
#3
Debopam Samanta, Raghu Ramakrishnaiah
No abstract text is available yet for this article.
March 23, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28407320/role-of-tlr4-and-mir-155-in-peripheral-blood-mononuclear-cell-mediated-inflammatory-reaction-in-coronary-slow-flow-and-coronary-arteriosclerosis-patients
#4
Jiangyan Huang, Qin Yang, Longmiao He, Jun Huang
BACKGROUND: To study the role of toll-like receptor 4 (TLR4) and MicroRNA-155 (miR-155) in the peripheral blood mononuclear cell (PBMC)-mediated inflammation in coronary slow flow (CSF) and coronary arteriosclerosis. METHODS: Patients were divided into acute coronary syndrome (ACS), stable angina pectoris (SAP), CSF, and healthy control (HC) groups. The isolated PBMCs were treated with lipopolysaccharide (LPS)/and antagomiR-155. TLR4, miR-155, and the concentrations of tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1, and IL-10 were measured...
April 13, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28407281/multiparametric-quantitative-ultrasound-imaging-in-assessment-of-chronic-kidney-disease
#5
Jing Gao, Alan Perlman, Safa Kalache, Nathaniel Berman, Surya Seshan, Steven Salvatore, Lindsey Smith, Natasha Wehrli, Levi Waldron, Hanish Kodali, James Chevalier
OBJECTIVES: To evaluate the value of multiparametric quantitative ultrasound imaging in assessing chronic kidney disease (CKD) using kidney biopsy pathologic findings as reference standards. METHODS: We prospectively measured multiparametric quantitative ultrasound markers with grayscale, spectral Doppler, and acoustic radiation force impulse imaging in 25 patients with CKD before kidney biopsy and 10 healthy volunteers. Based on all pathologic (glomerulosclerosis, interstitial fibrosis/tubular atrophy, arteriosclerosis, and edema) scores, the patients with CKD were classified into mild (no grade 3 and <2 of grade 2) and moderate to severe (at least 2 of grade 2 or 1 of grade 3) CKD groups...
April 13, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28392865/cardio-ankle-vascular-index-and-c-reactive-protein-are-useful-parameters-for-identification-of-ischemic-heart-disease-in-acute-heart-failure-patients
#6
Shunsuke Kiuchi, Shinji Hisatake, Takayuki Kabuki, Takashi Oka, Shintaro Dobashi, Takahiro Fujii, Takanori Ikeda
BACKGROUND: The most common cause of heart failure (HF) is ischemic heart disease (IHD). Evaluation of IHD with non-invasive examinations is useful for the treatment of HF, and cardio-ankle vascular index (CAVI) is a good parameter for detecting systemic arteriosclerosis. However, the relationship between IHD and CAVI in acute HF (AHF) patients is still unclear. Therefore, we investigated the effect of non-invasive examinations, including CAVI to detect IHD. METHODS: We studied 53 consecutive patients (average age of 66...
May 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28384800/effect-of-monthly-high-dose-vitamin-d-supplementation-on-cardiovascular-disease-in-the-vitamin-d-assessment-study-a-randomized-clinical-trial
#7
Robert Scragg, Alistair W Stewart, Debbie Waayer, Carlene M M Lawes, Les Toop, John Sluyter, Judy Murphy, Kay-Tee Khaw, Carlos A Camargo
Importance: Cohort studies have reported increased incidence of cardiovascular disease (CVD) among individuals with low vitamin D status. To date, randomized clinical trials of vitamin D supplementation have not found an effect, possibly because of using too low a dose of vitamin D. Objective: To examine whether monthly high-dose vitamin D supplementation prevents CVD in the general population. Design, Setting, and Participants: The Vitamin D Assessment Study is a randomized, double-blind, placebo-controlled trial that recruited participants mostly from family practices in Auckland, New Zealand, from April 5, 2011, through November 6, 2012, with follow-up until July 2015...
April 5, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28380656/early-results-of-surgical-simultaneous-therapy-for-significant-carotid-artery-stenosis-and-heart-disease
#8
Marc Irqsusi, Alessandro Vannucchi, Julius Beckers, Stefan Kasseckert, Stefan Waldhans, Sebastian Vogt, Rainer G H Moosdorf
Background The purpose of this single-center, retrospective study was to review the early outcome with defined endpoints of myocardial infarction, brain injury, and death after coronary bypass grafting and simultaneous carotid endarterectomy with or without combined valve replacement. Methods During the preoperative investigation 52 (44 males, 8 females) patients were examined by cardiac catheterization within the scope of their coronary status. In addition, all patients underwent echocardiography, CT angiography of the supra-aortic vessels, and full description of their neurologic status...
April 5, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28377342/-efficacy-of-drug-coated-balloon-and-common-balloon-for-treatment-of-superficial-femoral-artery-and-popliteal-artery-arteriosclerosis-obliterans-prospective-randomized-controlled-triac
#9
Jing-Yuan Lu, Jian-Ping Gu, Wen-Jian Xu, Wen-Sheng Lou, Tao Wang
OBJECTIVE: To compared the efficacy of drug-coated balloon and common balloon for treatment of superficial femoral artery and popliteal artery occlusive disease. METHODS: Forty-six patients were admitted for ipsilateral single or multiple superficial femoral artery and/or popliteal artery lesions (between 3 and 15 cm stenosis or occlusion), Rutherford grades 2 to 5, with or without other accompanying diseases in the Department of Interventional Vascular Therapy of the First Hospital of Nanjing between September, 2015 and December, 2016...
March 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28374891/short-term-hypoxia-reverses-ox-ldl-induced-cd36-and-glut4-switching-metabolic-pathways-in-h9c2-cardiomyoblast-cells
#10
Yeh-Peng Chen, Hsi-Hsien Hsu, Rathinasamy Baskaran, Su-Ying Wen, Chia-Yao Shen, Cecilia-Hsuan Day, Tsung-Jung Ho, Viswanadha Vijaya Padma, Wei-Wen Kuo, Chih-Yang Huang
High levels of circulating low-density lipoproteins (LDL, plasma proteins that carry cholesterol and triglycerides) are associated with type 2 diabetes, arteriosclerosis, obesity and hyperlipidemia. In the heart, the accumulation of oxidized low-density lipoprotein (Ox-LDL) has been proposed to play a role in the development of cardiovascular disease. We obtain cholesterol from animals and animal-derived foods such as milk, eggs and cheese. In previous studies, the ratio of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) was shown to be important for our health...
April 4, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28367899/antimicrobial-activity-of-the-chloroform-fraction-of-drynaria%C3%A2-fortunei-against-oral-pathogens
#11
Jeong-Dan Cha, Eun-Kyung Jung, Sung-Mi Choi, Kyung-Yeol Lee, Sung-Wook Kang
Drynaria fortunei (D. fortunei), widely used in traditional Korean medicine, is reportedly effective in treating inflammation, hyperlipidemia, bone fractures, oxidative damage, arteriosclerosis, rheumatism, and gynecological diseases. The objective of this study was to evaluate the antibacterial effects of the chloroform fraction of D. fortunei (DFCF) and assess the synergistic effects of DFCF with antibiotics against bacterial pathogens. This was carried out by calculating the minimal inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) and performing checkerboard dilution test and time-kill assays...
2017: Journal of Oral Science
https://www.readbyqxmd.com/read/28361119/evaluation-of-carotid-ultrasonography-screening-among-kidney-transplant-candidates-a-single-center-retrospective-study
#12
Chad W Rossitter, Ronald B Vigo, Ahmed Osama Gaber, Joshua T Swan, Wadi N Suki
BACKGROUND: Kidney transplant candidates undergo rigorous testing prior to clearance for transplantation. Because kidney transplant candidates may be at increased risk for carotid artery stenosis because of arteriosclerosis and atherosclerosis secondary to hypertension, vascular calcification, and diabetes, carotid ultrasound is often performed with the intent of preventing a cerebrovascular accident in the perioperative or posttransplant period. To our knowledge, there has not been a study investigating the utility of screening carotid ultrasonography in pretransplant candidates...
March 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28360225/biomarker-profiles-in-heart-failure-patients-with-preserved-and-reduced-ejection-fraction
#13
Jasper Tromp, Mohsin A F Khan, IJsbrand T Klip, Sven Meyer, Rudolf A de Boer, Tiny Jaarsma, Hans Hillege, Dirk J van Veldhuisen, Peter van der Meer, Adriaan A Voors
BACKGROUND: Biomarkers may help us to unravel differences in the underlying pathophysiology between heart failure (HF) patients with a reduced ejection fraction (HFrEF) and a preserved ejection fraction (HFpEF). Therefore, we compared biomarker profiles to characterize pathophysiological differences between patients with HFrEF and HFpEF. METHODS AND RESULTS: We retrospectively analyzed 33 biomarkers from different pathophysiological domains (inflammation, oxidative stress, remodeling, cardiac stretch, angiogenesis, arteriosclerosis, and renal function) in 460 HF patients (21% HFpEF, left ventricular ejection fraction ≥45%) measured at discharge after hospitalization for acute HF...
March 30, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28357515/clinical-features-and-predictors-of-patients-with-critical-limb-ischemia-who-responded-to-autologous-mononuclear-cell-transplantation-for-therapeutic-angiogenesis
#14
Naoyoshi Aoyama, Makoto Nishinari, Shinichi Ohtani, Akifumi Kanai, Chiharu Noda, Mitsuhiro Hirata, Akira Miyamoto, Masafumi Watanabe, Tohru Minamino, Tohru Izumi, Jyunya Ako
The clinical features of patients with critical limb ischemia (CLI) who responded to angiogenesis using autologous peripheral blood mononuclear cell transplantation (PB-MNC) have not yet been fully characterized, and there are no useful predictors to judge the curative effect in the early period after PB-MNC. This study sought to clarify the clinical features and predictors in patients with CLI who were successfully treated using PB-MNC. 30 consecutive patients [arteriosclerosis obliterans: 24 patients, thromboangiitis obliterans: 6 patients] who were diagnosed with major amputation despite maximal medical therapy were enrolled in this study...
March 29, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28356037/markers-of-early-vascular-ageing
#15
Vasilios Kotsis, Christina Antza, Ioannis Doundoulakis, Stella Stabouli
BACKGROUND: Cardiovascular damage is clinically manifested as coronary artery disease, heart failure, stroke and peripheral artery disease. The prevalence of these adverse conditions is higher with advancing age. Although many patients present cardiovascular damage late in their life, it is common to see patients with early atherosclerosis in cardiovascular intensive care units at ages lower than 50 years in men and 55 for women. METHODS AND RESULTS: In this review of the literature we identified risk factors of early vascular damage...
March 28, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28346354/anti-inflammatory-properties-of-irisin-mediator-of-physical-activity-are-connected-with-tlr4-myd88-signaling-pathway-activation
#16
Agnieszka Irena Mazur-Bialy, Ewa Pocheć, Marcin Zarawski
Irisin, an adipomiokine known as a mediator of physical activity, induces the browning of adipose tissue and it has potentially protective properties in the development of obesity-related states, such as insulin resistance, arteriosclerosis, and type 2 diabetes. Despite numerous studies conducted on this factor, still little is known about its impact on the functioning of immunocompetent cells, but its potential anti-inflammatory properties were previously suggested. In the current study we investigated the role of irisin (0-100 nM) in the downstream pathway activation of Toll-like receptor 4 (TLR4) in RAW 264...
March 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28339518/pain-interference-and-incident-medical-disorders-in-the-general-population
#17
Declan T Barry, Corey E Pilver Glenn, Rani A Hoff, Marc N Potenza
Objective. : To investigate the longitudinal relationship between pain interference and incident general medical conditions in a nationally representative sample. Methods. : Secondary data analysis comprising chi-square tests and binomial logistic regression analyses were performed on data obtained from the US National Epidemiologic Survey on Alcohol and Related Conditions from 34,465 adult respondents who completed wave 1 (2000-2001) and wave 2 (2004-2005) data collection...
October 20, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28332508/prolactin-as-a-predictor-of-endothelial-dysfunction-and-arterial-stiffness-progression-in-menopause
#18
G Georgiopoulos, I Lambrinoudaki, F Athanasouli, E Armeni, A Koliviras, A Augoulea, D Rizos, C Papamichael, A Protogerou, K Stellos, K Stamatelopoulos
Postmenopausal women are at increased risk for progression of arteriosclerosis and hypertension. Recent cross-sectional evidence suggests that high normal circulating prolactin levels may accelerate vascular ageing in menopause. Postmenopausal women (n=201) were consecutively recruited from a Menopause Clinic and re-evaluated in at least one follow-up visit within the next 3 years. Baseline circulating prolactin levels were measured while both baseline and follow-up vascular and biochemical measurements were performed...
March 23, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28331635/relationships-among-ocular-blood-flow-shown-by-laser-speckle-flowgraphy-retinal-arteriosclerotic-change-and-chorioretinal-circulation-time-obtained-by-fluorescein-angiography
#19
Hironori Osamura, Tomoaki Shiba, Takashi Itokawa, Tadashi Matsumoto, Yuichi Hori
Purpose. To determine the correlations among the mean blur rate (MBR) in the optic nerve head (ONH) shown by laser speckle flowgraphy (LSFG), retinal arteriosclerosis, and the circulation time obtained by fluorescein angiography (FA). Method. We evaluated 118 patients and assessed their time of choroidal flush, arm-to-retina time, and early and late phases of retinal circulation time (RT: sec) obtained by FA. The severity of retinal arteriosclerosis was classified according to the Scheie classification. The MBR values throughout the ONH (MBR-A), in the tissue (MBR-T), and in the vessels (MBR-V) were analyzed...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28321055/the-relationships-between-the-differences-in-the-central-blood-pressure-and-brachial-blood-pressure-and-other-factors-in-patients-with-essential-hypertension
#20
Masaki Ryuzaki, Satoshi Morimoto, Michita Niiyama, Yasufumi Seki, Naohiro Yoshida, Yoichi Oshima, Yuki Mizuguchi, Daisuke Watanabe, Takashi Ando, Atsuhiro Ichihara
Objective The management of blood pressure (BP) in hypertensive patients is the key to preventing a progression of organ damage. The brachial BP (bBP) has been used as the representative method for measuring the BP. The central BP (cBP), which is, different from the bBP due to the propagation and the reflection of the pulse wave in the arterial system, has recently received attention because it can now be estimated non-invasively. We examined the relationships between the difference in the central systolic BP (csBP) and the brachial systolic BP (bsBP) (Δ) and other factors in hypertensive patients...
2017: Internal Medicine
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