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https://www.readbyqxmd.com/read/28346354/anti-inflammatory-properties-of-irisin-mediator-of-physical-activity-are-connected-with-tlr4-myd88-signaling-pathway-activation
#1
Agnieszka Irena Mazur-Bialy, Ewa Pocheć, Marcin Zarawski
Irisin, an adipomiokine known as a mediator of physical activity, induces the browning of adipose tissue and it has potentially protective properties in the development of obesity-related states, such as insulin resistance, arteriosclerosis, and type 2 diabetes. Despite numerous studies conducted on this factor, still little is known about its impact on the functioning of immunocompetent cells, but its potential anti-inflammatory properties were previously suggested. In the current study we investigated the role of irisin (0-100 nM) in the downstream pathway activation of Toll-like receptor 4 (TLR4) in RAW 264...
March 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28339518/pain-interference-and-incident-medical-disorders-in-the-general-population
#2
Declan T Barry, Corey E Pilver Glenn, Rani A Hoff, Marc N Potenza
Objective. : To investigate the longitudinal relationship between pain interference and incident general medical conditions in a nationally representative sample. Methods. : Secondary data analysis comprising chi-square tests and binomial logistic regression analyses were performed on data obtained from the US National Epidemiologic Survey on Alcohol and Related Conditions from 34,465 adult respondents who completed wave 1 (2000-2001) and wave 2 (2004-2005) data collection...
October 20, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28332508/prolactin-as-a-predictor-of-endothelial-dysfunction-and-arterial-stiffness-progression-in-menopause
#3
G Georgiopoulos, I Lambrinoudaki, F Athanasouli, E Armeni, A Koliviras, A Augoulea, D Rizos, C Papamichael, A Protogerou, K Stellos, K Stamatelopoulos
Postmenopausal women are at increased risk for progression of arteriosclerosis and hypertension. Recent cross-sectional evidence suggests that high normal circulating prolactin levels may accelerate vascular ageing in menopause. Postmenopausal women (n=201) were consecutively recruited from a Menopause Clinic and re-evaluated in at least one follow-up visit within the next 3 years. Baseline circulating prolactin levels were measured while both baseline and follow-up vascular and biochemical measurements were performed...
March 23, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28331635/relationships-among-ocular-blood-flow-shown-by-laser-speckle-flowgraphy-retinal-arteriosclerotic-change-and-chorioretinal-circulation-time-obtained-by-fluorescein-angiography
#4
Hironori Osamura, Tomoaki Shiba, Takashi Itokawa, Tadashi Matsumoto, Yuichi Hori
Purpose. To determine the correlations among the mean blur rate (MBR) in the optic nerve head (ONH) shown by laser speckle flowgraphy (LSFG), retinal arteriosclerosis, and the circulation time obtained by fluorescein angiography (FA). Method. We evaluated 118 patients and assessed their time of choroidal flush, arm-to-retina time, and early and late phases of retinal circulation time (RT: sec) obtained by FA. The severity of retinal arteriosclerosis was classified according to the Scheie classification. The MBR values throughout the ONH (MBR-A), in the tissue (MBR-T), and in the vessels (MBR-V) were analyzed...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28321055/the-relationships-between-the-differences-in-the-central-blood-pressure-and-brachial-blood-pressure-and-other-factors-in-patients-with-essential-hypertension
#5
Masaki Ryuzaki, Satoshi Morimoto, Michita Niiyama, Yasufumi Seki, Naohiro Yoshida, Yoichi Oshima, Yuki Mizuguchi, Daisuke Watanabe, Takashi Ando, Atsuhiro Ichihara
Objective The management of blood pressure (BP) in hypertensive patients is the key to preventing a progression of organ damage. The brachial BP (bBP) has been used as the representative method for measuring the BP. The central BP (cBP), which is, different from the bBP due to the propagation and the reflection of the pulse wave in the arterial system, has recently received attention because it can now be estimated non-invasively. We examined the relationships between the difference in the central systolic BP (csBP) and the brachial systolic BP (bsBP) (Δ) and other factors in hypertensive patients...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28317490/speculative-considerations-about-some-cardiology-enigmas
#6
Paulo Roberto Barbosa Evora, Andre Schmidt, Livia Arcêncio, José Antonio Marin-Neto
Write a review text or point-of-view that takes into account the interests, if not of all, but of most readers of a scientific journal is an arduous task. The editorial can be grounded in published articles, even in a single article of undeniable importance and, it can also represent a trend of specialty. Therefore, especially for the sake of the reader's motivation, the present text was freely designed to discuss some cardiology enigmas in the context of the heart valve and coronary artery disease (CAD). Concerning the CAD five well-known enigmas will be considered: 1) The absence of arteriosclerosis in intramyocardial coronary arteries; 2) The unique and always confirmed superior evolution of the left internal thoracic artery as a coronary graft; 3) The prophylactic left internal thoracic artery graft in mildly-stenosed coronary lesions, and; 4) The high incidence of perioperative atrial fibrillation (AF) in patients with CAD, and; 5) The handling of disease-free saphenous vein graft at the time of reoperation...
March 17, 2017: Current Cardiology Reviews
https://www.readbyqxmd.com/read/28314581/a-proposal-for-standardized-grading-of-chronic-changes-in-native-kidney-biopsy-specimens
#7
Sanjeev Sethi, Vivette D D'Agati, Cynthia C Nast, Agnes B Fogo, An S De Vriese, Glen S Markowitz, Richard J Glassock, Fernando C Fervenza, Surya V Seshan, Andrew Rule, Lorraine C Racusen, Jai Radhakrishnan, Christopher G Winearls, Gerald B Appel, Ingeborg M Bajema, Anthony Chang, Robert B Colvin, H Terence Cook, Sundaram Hariharan, Loren P Herrera Hernandez, Neeraja Kambham, Michael Mengel, Karl A Nath, Helmut G Rennke, Pierre Ronco, Brad H Rovin, Mark Haas
Chronic changes represent an important component of native kidney biopsy evaluation and have a major bearing on predicting prognosis and guiding treatment. We propose here a uniform, semiquantitative approach to assessing such changes, which include glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arteriosclerosis, and we report these findings as an overall chronicity grade.
April 2017: Kidney International
https://www.readbyqxmd.com/read/28292575/the-treatment-of-type-2-diabetes-mellitus-in-patients-with-chronic-kidney-disease-what-to-expect-from-new-oral-hypoglycemic-agents
#8
REVIEW
Luca Di Lullo, Michela Mangano, Claudio Ronco, Vincenzo Barbera, Antonio De Pascalis, Antonio Bellasi, Domenico Russo, Biagio Di Iorio, Mario Cozzolino
Worldwide, an estimated 200 million people have chronic kidney disease (CKD), whose most common causes include hypertension, arteriosclerosis, and diabetes. About 40% of patients with diabetes develop CKD and intensive blood glucose control through pharmacological intervention can delay CKD progression. Standard therapies for the treatment of type 2 diabetes mellitus include metformin, sulfonylureas, meglitinides, thiazolidinediones, and insulin. While these drugs have an important role in the management of type 2 diabetes, only the thiazolidinedione pioglitazone can be used across the spectrum of CKD (stages 2-5) and without dose adjustment...
March 6, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28287021/evaluation-of-a-static-stretching-intervention-on-vascular-endothelial-function-and-arterial-stiffness
#9
Hiromi Shinno, Satoshi Kurose, Yutaka Yamanaka, Kyoko Higurashi, Yaeko Fukushima, Hiromi Tsutsumi, Yutaka Kimura
PURPOSE: Maintenance and enhancement of vascular endothelial function contribute to the prevention of cardiovascular disease and prolong a healthy life expectancy. Given the reversible nature of vascular endothelial function, interventions to improve this function might prevent arteriosclerosis. Accordingly, we studied the effects of a 6-month static stretching intervention on vascular endothelial function (reactive hyperaemia peripheral arterial tonometry index: RH-PAT index) and arterial stiffness (brachial-ankle pulse wave velocity: baPWV) and investigated the reversibility of these effects after a 6-month detraining period following intervention completion...
March 13, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28275590/protocol-for-evaluating-the-cardio-ankle-vascular-index-to-predict-cardiovascular-events-in-japan-a-prospective-multicenter-cohort-study
#10
REVIEW
Toru Miyoshi, Hiroshi Ito, Shigeo Horinaka, Kohji Shirai, Jitsuo Higaki, Hajime Orimio
INTRODUCTION: The cardio-ankle vascular index (CAVI) was developed in Japan and is a blood pressure-independent index of arterial stiffness from the origin of the aorta to the ankle. In recent years, it has been studied by many researchers worldwide, and it is strongly anticipated that it will play a role as a predictive factor for arteriosclerotic diseases. The objective of this study was to examine the benefits of using CAVI as a predictor of cardiovascular events in high-risk patients...
January 2017: Pulse (Basel, Switzerland)
https://www.readbyqxmd.com/read/28269012/cfd-analysis-of-strut-influence-on-blood-flow-in-stent-implanted-left-main-coronary-artery-bifurcation
#11
Yuya Yamada, Takahiro Tsukahara, Masahiro Motosuke, Yusuke Fujino
We numerically studied blood flows in a simulated branching pipe of coronary artery bifurcation, which is affected by stent implantation. We found that stent struts provide effects as guide vanes and blockages on the flow into circumflex branch. The former effect increases the flow rate and shear stress on the arteriosclerosis-prone site. The blockage effect may overwhelm the guide effect depending on a strut position against the inflow.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268802/development-of-an-earlobe-crease-identification-system-to-support-diagnosis-of-arteriosclerosis
#12
Harutoyo Hirano, Ryosuke Katsumata, Masato Futagawa, Toshio Tsuji, Shinji Kishimoto, Nozomu Oda, Masato Kajikawa, Tatsuya Maruhashi, Yukihito Higashi
It is well known that an earlobe crease (ELC) is related with cardiovascular disease. However evaluation of ELC has been carried out subjectively. We propose a novel system for objective and quantitative evaluation of ELC characteristics. The outline of earlobe was detected using the Canny edge detector. The number of ELCs and the ratio of the ELC length for the lobule from photographs of bilateral earlobes were calculated from the extracted outline of earlobes. Our system's validity for ELCs detection was compared with doctors' diagnosis using sensitivity and specificity analysis...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28260093/recombinant-adeno-associated-virus-serotype-9-in-a-mouse-model-of-atherosclerosis-determination-of-the-optimal-expression-time-in%C3%A2-vivo
#13
Qingjie Chen, Hui Zhai, Xiaomei Li, Yitong Ma, Bangdang Chen, Fen Liu, Hongmei Lai, Jia Xie, Chunhui He, Junyi Luo, Jing Gao, Yining Yang
Adeno-associated virus 9 (AAV9) has been identified as one of the optimal gene transduction carriers for gene therapy. The aim of the present study was to determine the gene transfection efficiency and safety of an AAV9 vector produced using a recombinant baculovirus (rBac)‑based system. AAV9‑cytomegalovirus (CMV)-green fluorescent protein was produced using an rBac system and the resulting vector particles were injected intravenously into mice. Animals were sacrificed at 14, 21, 28, 35, 60, 90 and 120 days following injection...
February 22, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28259649/role-of-the-liver-x-receptors-in-skin-physiology-putative-pharmacological-targets-in-human-diseases
#14
REVIEW
Zangbéwendé Guy Ouedraogo, Allan Fouache, Amalia Trousson, Silvère Baron, Jean-Marc A Lobaccaro
Liver X receptors (LXRs) are members of the nuclear receptor superfamily that have been shown to regulate various physiological functions such as lipid metabolism and cholesterol homeostasis. Concordant reports have elicited the possibility to target them to cure many human diseases including arteriosclerosis, cancer, arthritis, and diabetes. The high relevance of modulating LXR activities to treat numerous skin diseases, mainly those with exacerbated inflammation processes, contrasts with the lack of approved therapeutic use...
March 1, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28239169/cardiovascular-disease-in-haemodialysis-role-of-the-intravascular-innate-immune-system
#15
REVIEW
Kristina N Ekdahl, Inga Soveri, Jöns Hilborn, Bengt Fellström, Bo Nilsson
Haemodialysis is a life-saving renal replacement modality for end-stage renal disease, but this therapy also represents a major challenge to the intravascular innate immune system, which is comprised of the complement, contact and coagulation systems. Chronic inflammation is strongly associated with cardiovascular disease (CVD) in patients on haemodialysis. Biomaterial-induced contact activation of proteins within the plasma cascade systems occurs during haemodialysis and initially leads to local generation of inflammatory mediators on the biomaterial surface...
February 27, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28227224/cfd-analysis-of-strut-influence-on-blood-flow-in-stent-implanted-left-main-coronary-artery-bifurcation
#16
Yuya Yamada, Takahiro Tsukahara, Masahiro Motosuke, Yusuke Fujino, Yuya Yamada, Takahiro Tsukahara, Masahiro Motosuke, Yusuke Fujino, Takahiro Tsukahara, Yuya Yamada, Yusuke Fujino, Masahiro Motosuke
We numerically studied blood flows in a simulated branching pipe of coronary artery bifurcation, which is affected by stent implantation. We found that stent struts provide effects as guide vanes and blockages on the flow into circumflex branch. The former effect increases the flow rate and shear stress on the arteriosclerosis-prone site. The blockage effect may overwhelm the guide effect depending on a strut position against the inflow.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226997/development-of-an-earlobe-crease-identification-system-to-support-diagnosis-of-arteriosclerosis
#17
Harutoyo Hirano, Ryosuke Katsumata, Masato Futagawa, Toshio Tsuji, Shinji Kishimoto, Nozomu Oda, Masato Kajikawa, Tatsuya Maruhashi, Yukihito Higashi, Harutoyo Hirano, Ryosuke Katsumata, Masato Futagawa, Toshio Tsuji, Shinji Kishimoto, Nozomu Oda, Masato Kajikawa, Tatsuya Maruhashi, Yukihito Higashi, Tatsuya Maruhashi, Toshio Tsuji, Shinji Kishimoto, Masato Kajikawa, Ryosuke Katsumata, Yukihito Higashi, Masato Futagawa, Harutoyo Hirano, Nozomu Oda
It is well known that an earlobe crease (ELC) is related with cardiovascular disease. However evaluation of ELC has been carried out subjectively. We propose a novel system for objective and quantitative evaluation of ELC characteristics. The outline of earlobe was detected using the Canny edge detector. The number of ELCs and the ratio of the ELC length for the lobule from photographs of bilateral earlobes were calculated from the extracted outline of earlobes. Our system's validity for ELCs detection was compared with doctors' diagnosis using sensitivity and specificity analysis...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28217013/contributions-to-the-study-of-blood-brain-flux-using-radioactive-tracers
#18
Ioan Mureşan, Ioan Cosma
In this paper, we present an original radiocirculographic method for investigates of cerebral blood flow, which has proven to be very useful, simple, and efficient for studies of brain hemodynamics. Physical considerations on injected radioactive tracer in cardiovascular system, allowed us to state a relationship for the blood flux, F, valued as the amount of fluid-blood that traverses a vascular segment in unit time. All these theoretical facts, along with a host of remarkable clinical results, are presented in a doctoral thesis entitled "The cerebral Hemodynamics in Essential Hypertension and Arteriosclerosis" of the eminent doctor Ioan Mures,an, who died in 1984, at only 50 years old...
January 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28203023/-randomized-controlled-trial-to-superficial-femoral-artery-recanalization-for-lower-extremity-arteriosclerosis-obliterans
#19
J M Zhuang, X Li, T R Li, J Zhao, J Y Luan, C M Wang
OBJECTIVE: To evaluate the safety and effectiveness of neglecting superficial femoral artery (SFA) recanalization for chronic lower extremity arteriosclerosis obliterans (ASO). METHODS: Thirty-six cases treated for severe stenosis or occlusion of superficial femoral artery resulted from ASO were randomly divided into 2 groups. Twenty of them were treated by endovascular reconstruction of superficial femoral artery and the other 16 cases were not treated with their superficial femoral artery, but were only treated with the accompanied iliac and/or profunda femoral artery lesion...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28202829/-treatment-strategy-and-results-of-carotid-endarterectomy-in-chronic-renal-failure-patients
#20
Takeo Murahashi, Kenji Kamiyama, Toshiaki Osato, Toshiichi Watanabe, Tatsuya Ogino, Hironori Sugio, Hideki Endo, Kazuki Takahira, Koichiro Shindo, Shuhei Takahashi, Hirohiko Nakamura
INTRODUCTION: The number of patients receiving chronic dialysis treatment in Japan currently exceeds 300,000 people. Few reports have described carotid endarterectomy(CEA)for chronic renal failure patients because of the unacceptable rate of perioperative stroke and other morbidities. A strategy for and treatment results of CEA for chronic renal failure patients in our hospital are described herein. METHODS: The present study included 6 patients who underwent CEA while receiving dialysis treatment between April 2011 and November 2014...
February 2017: No Shinkei Geka. Neurological Surgery
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