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https://www.readbyqxmd.com/read/29682164/defective-autophagy-in-atherosclerosis-to-die-or-to-senesce
#1
REVIEW
Mandy O J Grootaert, Lynn Roth, Dorien M Schrijvers, Guido R Y De Meyer, Wim Martinet
Autophagy is a subcellular process that plays an important role in the degradation of proteins and damaged organelles such as mitochondria (a process termed "mitophagy") via lysosomes. It is crucial for regulating protein and mitochondrial quality control and maintaining cellular homeostasis, whereas dysregulation of autophagy has been implicated in a wide range of diseases including atherosclerosis. Recent evidence has shown that the autophagic process becomes dysfunctional during the progression of atherosclerosis, regardless of whether there are many autophagy-stimulating factors (e...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29665863/effect-of-combined-treatment-with-bisphosphonate-and-vitamin-d-on-atherosclerosis-in-patients-with-systemic-lupus-erythematosus-a-propensity-score-based-analysis
#2
Kazumasa Ohmura, Masaru Kato, Toshiyuki Watanabe, Kenji Oku, Toshiyuki Bohgaki, Tetsuya Horita, Shinsuke Yasuda, Yoichi M Ito, Norihiro Sato, Tatsuya Atsumi
BACKGROUND: Premature atherosclerosis is one of the major complications of systemic lupus erythematosus (SLE). Recently, the biological linkage between atherosclerosis and osteoporosis has garnered much attention. The aim of this study is to explore correlation between the development of atherosclerosis and anti-osteoporotic treatment. METHODS: Consecutive patients with SLE (n = 117) who underwent carotid ultrasonography were retrospectively analyzed using propensity scoring...
April 17, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29615006/selected-risk-factors-for-atherosclerosis-in-children-and-their-parents-with-positive-family-history-of-premature-cardiovascular-diseases-a-prospective-study
#3
Elzbieta Pac-Kozuchowska, Paulina Krawiec, Ewelina Grywalska
BACKGROUND: The aim of the study was to evaluate serum parameters of lipid metabolism, homocysteine, soluble adhesion molecules and common carotid artery wall thickness in children from families with early symptoms of atherosclerosis. METHODS: The first stage included 137 pairs of mothers and newborns, and the second 18 children from the same group (age 18-30 months) and their parents (age 21-46 years) with a history of premature coronary artery disease (CAD), as well as 12 age- and sex-matched controls...
April 3, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29614967/cardiovascular-outcomes-of-nephrotic-syndrome-in-childhood-cvons-study-a-protocol-for-prospective-cohort-study
#4
S K Patnaik, P Kumar, M Bamal, S Patel, M P Yadav, V Kumar, A Sinha, A Bagga, M Kanitkar
BACKGROUND: Nephrotic syndrome (NS) is characterized by dyslipidemia which is a well-known risk factor for atherogenesis. Atherosclerosis in childhood is mostly subclinical and endothelial dysfunction is known to precede this. Evidence for screening for endothelial dysfunction and cardiovascular risk factors and early identification of premature onset of atherosclerosis in childhood NS remains tenuous in the absence of well-designed prospective studies addressing cardiovascular comorbidity in NS...
April 3, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29609748/impact-of-lipoproteins-on-atherobiology-emerging-insights
#5
REVIEW
Ma Feng, Fabiana Rached, Anatol Kontush, M John Chapman
Apolipoprotein B-containing lipoproteins and low-density lipoprotein play a key role in atherosclerotic vascular disease. Modified forms of low-density lipoprotein drive inflammation, an integral aspect of plaque progression. High-density lipoprotein particles are equipped to protect low-density lipoprotein from enzymatic and nonenzymatic modification. Under normal conditions, high-density lipoproteins facilitate cholesterol efflux from tissues, preventing its accumulation with deleterious consequences. However, the high-density lipoprotein particles characteristic of dyslipidemic states associated with premature atherosclerosis are typically dysfunctional as a result of alteration in their metabolism and consequently their structure and composition...
May 2018: Cardiology Clinics
https://www.readbyqxmd.com/read/29602596/mechanisms-of-vascular-aging-what-can-we-learn-from-hutchinson-gilford-progeria-syndrome
#6
Lara Del Campo, Magda R Hamczyk, Vicente Andrés, José Martínez-González, Cristina Rodríguez
Aging is the main risk factor for cardiovascular disease (CVD). The increased prevalence of CVD is partly due to the global increase in life expectancy. In this context, it is essential to identify the mechanisms by which aging induces CVD, with the ultimate aim of reducing its incidence. Both atherosclerosis and heart failure significantly contribute to age-associated CVD morbidity and mortality. Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by the synthesis of progerin, which is noted for accelerated aging and CVD...
March 27, 2018: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/29578362/molecular-aspects-of-hypercholesterolemia-treatment-current-perspectives-and-hopes
#7
Najmeh Ahangari, Majid Ghayour Mobarhan, Amir Hosein Sahebkar, Alireza Pasdar
BACKGROUND: Hypercholesterolemia is a pathological condition which has been reported in 39% of the worlds' adult population. We aimed to review molecular aspects of current and novel therapeutic approaches based on low-density lipoprotein cholesterol lowering strategies. METHODS: Searching through PubMed and Scopus databases for relative articles using the following keywords have been done: Hypercholesterolemia, Therapy, lipid-lowering drugs, low-density lipoprotein cholesterol...
March 26, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29575872/premature-atherosclerosis-after-treatment-for-acute-lymphoblastic-leukemia-in-childhood
#8
Elżbieta Sadurska, Agnieszka Zaucha-Prażmo, Agnieszka Brodzisz, Jerzy Kowalczyk, Iwona Beń-Skowronek
INTRODUCTION: Late cardiovascular complications are the leading causes of morbidity and mortality in patients treated for common malignancies of childhood. Late cardiotoxicity include increased development of atherosclerosis and atherosclerosis - related diseases. An evaluation of the endothelium can be made based on the measurement of endothelium-derived blood vasoactive factors, such as cytokines and adhesion molecules. Their elevated serum levels may serve as sensitive indicators of early atherosclerotic lesions in high risk patients...
March 14, 2018: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29571349/two-cases-of-surgical-management-of-supravalvular-aortic-stenosis-in-familial-hypercholesterolemia
#9
Takashi Kakuta, Tomoyuki Fujita, Satsuki Fukushima, Naonori Kawamoto, Yorihiko Matsumoto, Kizuku Yamashita, Yusuke Shimahara, Hatsue Ishibashi-Ueda, Mariko Harada-Shiba, Junjiro Kobayashi
Homozygous familial hypercholesterolemia is a rare autosomal dominant disorder caused by gene mutations of the low-density lipoprotein receptor, generally characterized by three major signs-hyper low-density lipoprotein cholesterolemia, tendon/skin xanthomas, and premature atherosclerosis disease-beginning in childhood and including supravalvular aortic stenosis. To the best of our knowledge, only a few successful surgical cases for supravalvular aortic stenosis in these patients have been reported. We report two cases of homozygous familial hypercholesterolemia with severe supravalvular aortic stenosis and coronary artery disease associated with very small aortic root, managed by aortic root replacement concomitant with coronary artery bypass graft surgery, which resulted in excellent postoperative outcomes...
April 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29570616/efficacy-of-nutritional-interventions-on-inflammatory-markers-in-haemodialysis-patients-a-systematic-review-and-limited-meta-analysis
#10
REVIEW
Ban-Hock Khor, Sreelakshmi Sankara Narayanan, Sharmela Sahathevan, Abdul Halim Abdul Gafor, Zulfitri Azuan Mat Daud, Pramod Khosla, Alice Sabatino, Enrico Fiaccadori, Karuthan Chinna, Tilakavati Karupaiah
Low-grade chronic inflammation is prevalent in patients undergoing haemodialysis (HD) treatment and is linked to the development of premature atherosclerosis and mortality. The non-pharmacological approach to treat inflammation in HD patients through nutritional intervention is well cited. We aimed to assess the efficacy of different nutritional interventions at improving inflammatory outcomes in HD patients, based on markers such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumour necrosis factor-α (TNF-α)...
March 23, 2018: Nutrients
https://www.readbyqxmd.com/read/29555305/basic-vs-more-complex-definitions-of-family-history-in-the-prediction-of-coronary-heart-disease-the-multi-ethnic-study-of-atherosclerosis
#11
Jaideep Patel, Mahmoud Al Rifai, Maren T Scheuner, Steven Shea, Roger S Blumenthal, Khurram Nasir, Michael J Blaha, John W McEvoy
OBJECTIVE: To determine whether family history of coronary heart disease (FH) definitions differ in their association with atherosclerotic cardiovascular disease (ASCVD) events. PATIENTS AND METHODS: Participants who provided FH data from July 17, 2000, through February 24, 2004, were identified. Definitions of FH were any, premature, and Familial Risk Assessment (FRA). Outcomes included coronary heart disease (CHD), stroke, peripheral artery disease, angina, and congestive heart failure...
March 16, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29550494/elevated-lipoprotein-a-levels-are-associated-with-coronary-artery-calcium-scores-in-asymptomatic-individuals-with-a-family-history-of-premature-atherosclerotic-cardiovascular-disease
#12
Simone L Verweij, Maurice W J de Ronde, Rutger Verbeek, S Matthijs Boekholdt, R Nils Planken, Erik S G Stroes, Sara-Joan Pinto-Sietsma
BACKGROUND: Elevated lipoprotein(a) (Lp(a)) levels are associated with increased risk for atherosclerotic cardiovascular disease (ASCVD). Individuals with a family history of premature ASCVD are at increased cardiovascular risk with concomitantly a higher burden of (subclinical) atherosclerosis. However, whether Lp(a) contributes to the increased atherosclerotic burden in these individuals remains to be established. OBJECTIVE: In this study, we evaluated the association between Lp(a) levels and coronary atherosclerotic burden, assessed by coronary arterty calcium (CAC) scores, in asymptomatic individuals with a family history of premature ASCVD...
February 16, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29543531/mif-deficiency-favors-an-atheroprotective-autoantibody-phenotype-in-atherosclerosis
#13
Corinna Schmitz, Heidi Noels, Omar El Bounkari, Eva Straussfeld, Remco T A Megens, Marieke Sternkopf, Setareh Alampour-Rajabi, Christine Krammer, Pathricia V Tilstam, Norbert Gerdes, Christina Bürger, Aphrodite Kapurniotu, Richard Bucala, Joachim Jankowski, Christian Weber, Jürgen Bernhagen
The inflammatory cytokine macrophage migration-inhibitory factor (MIF) promotes atherosclerosis via lesional monocyte and T-cell recruitment. B cells have emerged as important components in atherogenesis, but the interaction between MIF and B cells in atherogenesis is unknown. Here, we investigated the atherosclerotic phenotype of Mif-gene deletion in Apoe-/- mice. Apoe-/- Mif-/- mice on a Western-diet exhibited strongly reduced atherosclerotic lesions in brachiocephalic artery (BC) and abdominal aorta compared with controls...
March 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29538084/carotid-intima-media-thickness-and-lipid-profile-in-children-with-kawasaki-disease-a-single-center-follow-up-study-after-a-mean-duration-of-6-9-years
#14
Kavitha Gopalan, Surjit Singh, Pandiarajan Vignesh, Anju Gupta, Manojkumar Rohit, Savita Verma Attri
BACKGROUND: Kawasaki disease (KD) has a predilection to involve coronary arteries, leading to several long-term cardiovascular sequelae. Apart from coronary artery abnormalities, children with KD are also prone to develop premature atherosclerosis, endothelial dysfunction, and lipid abnormalities. Some of these complications may occur even in children who have received appropriate treatment with intravenous immunoglobulin in the acute phase. METHODS: In 2009, we had studied carotid intima-media thickness (cIMT) and lipid profile in 27 children with KD at least 1 year after the acute episode...
March 13, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29534662/primary-bullous-keratopathy-in-a-patient-with-werner-syndrome-treated-with-corneal-transplant
#15
Divya Singh, Anita Ganger, Noopur Gupta, Murugesan Vanathi, Rajesh Khadgawat, Radhika Tandon
Here, we present, to the best of our knowledge, the first case of Werner syndrome with corneal blindness due to bilateral primary bullous keratopathy. Werner syndrome is a rare autosomal recessive disorder characterized by features of premature aging, insulin-dependent diabetes mellitus, osteoporosis, atherosclerosis, hypergonadotrophic hypogonadism, hypertriglyceridemia, scleroderma-like skin changes, and sarcomas. Among ocular manifestations, cataracts, cystoid macular edema, and retinal detachment have been reported...
March 9, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29531935/a-rare-missense-mutation-and-a-polymorphism-with-high-frequency-in-ldlr-gene-among-iranian-patients-with-familial-hypercholesterolemia
#16
Masoud Tajamolian, Parisa Kolahdouz, Parvaneh Nikpour, Seyed Khalil Forouzannia, Mohammad Hasan Sheikhha, Ehsan Farashahi Yazd
Background: Familial hypercholesterolemia (FH) is a disorder that is inherited by autosomal dominant pattern. The main cause of FH disease is the occurrence of mutations in low-density lipoprotein receptor (LDLR) gene sequence, as well as apolipoprotein B and proprotein convertase subtilisin/kexin type 9 genes, located in the next ranks, respectively. Materials and Methods: Forty-five unrelated Iranian patients with FH were screened using a high-resolution melting (HRM) method for exon 9 along with intron/exon boundaries of LDLR gene...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29512862/microrna-216a-induces-endothelial-senescence-and-inflammation-via-smad3-i%C3%AE%C2%BAb%C3%AE-pathway
#17
Shujun Yang, Xuenan Mi, Yu Chen, Congrui Feng, Zhihui Hou, Rutai Hui, Weili Zhang
Vascular endothelial senescence contributes to atherosclerosis and coronary artery disease (CAD), but the mechanisms are yet to be clarified. We identified that microRNA-216a (miR-216a) significantly increased in senescent endothelial cells. The replicative senescence model of human umbilical vein endothelial cells (HUVECs) was established to explore the role of miR-216a in endothelial ageing and dysfunction. Luciferase assay indicated that Smad3 was a direct target of miR-216a. Stable expression of miR-216a induced a premature senescence-like phenotype in HUVECs with an impairment in proliferation and migration and led to an increased adhesion to monocytes by inhibiting Smad3 expression and thereafter modulating the degradation of NF-κB inhibitor alpha (IκBα) and activation of adhesion molecules...
March 7, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29498872/-familial-combined-hyperlipidemia-the-most-common-genetic-dyslipidemia-in-population-and-in-patients-with-premature-atherothrombotic-cardiovascular-disease
#18
Helena Vaverková, David Karásek
Familial combined hyperlipidemia (FCH) is the most frequent genetic dyslipidemia (DLP) with high risk of early atherosclerosis manifestation. It is characterized by elevated both triglycerides 1.5 mmol/l and apolipoprotein B 1.2 g/l (hyper-TG/hyper-ApoB fenotype), with at least two affected family members. Despite the fact that plasmatic levels of total cholesterol and LDL-C are usually lower than in familial hypercholesterolemia and full expression of DLP in FCH occurs in adulthood, risk of premature manifestation of atherosclerosis is similar in both these familial DLP...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29490993/vascular-smooth-muscle-specific-progerin-expression-accelerates-atherosclerosis-and-death-in-a-mouse-model-of-hutchinson-gilford-progeria-syndrome
#19
Magda R Hamczyk, Ricardo Villa-Bellosta, Pilar Gonzalo, María J Andrés-Manzano, Paula Nogales, Jacob F Bentzon, Carlos López-Otín, Vicente Andrés
Background -Progerin, an aberrant protein that accumulates with age, causes the rare genetic disease Hutchinson-Gilford progeria syndrome (HGPS). HGPS patients with ubiquitous progerin expression exhibit accelerated aging and atherosclerosis, and die in their early teens mainly from myocardial infarction or stroke. The mechanisms underlying progerin-induced atherosclerosis remain unexplored, in part due to the lack of appropriate animal models. Methods -We generated an atherosclerosis-prone model of HGPS by crossing apolipoprotein E-deficient ( Apoe-/- ) mice with LmnaG609G/G609G mice ubiquitously expressing progerin...
February 28, 2018: Circulation
https://www.readbyqxmd.com/read/29473041/the-role-of-statins-in-disease-modification-and-cardiovascular-risk-in-rheumatoid-arthritis
#20
REVIEW
Stergios Soulaidopoulos, Elena Nikiphorou, Theodoros Dimitroulas, George D Kitas
Rheumatoid arthritis (RA) is an autoimmune, inflammatory disorder associated with excess cardiovascular morbidity and mortality. A complex interplay between traditional risk factors (dyslipidemia, insulin resistance, arterial hypertension, obesity, smoking) and chronic inflammation is implicated in the development of premature atherosclerosis and consequently in the higher incidence of cardiovascular events observed in RA patients. Despite the acknowledgment of elevated cardiovascular risk among RA individuals, its management remains suboptimal...
2018: Frontiers in Medicine
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