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premature atherosclerosis

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https://www.readbyqxmd.com/read/29204234/carotid-doppler-ultrasonography-as-a-screening-tool-of-early-atherosclerotic-changes-in-children-and-young-adults-with-%C3%AE-thalassemia-major
#1
Seif El-Din Abaza, Amina Abdel-Salam, Ahmed A Baz, Amira A Mohamed
Purpose: β-thalassemia major (β-TM) patients had an increased incidence of cardiovascular complications secondary to iron overload. They showed early carotid atherosclerosis as showed by increased carotid intima media thickness (CIMT) that may occur early even when significant iron overload is absent. We aimed to test the diagnostic performance of CIMT measurement by Doppler ultrasonography as a structural indicator for premature atherosclerosis in β-TM patients. Methods: Case-control study included 42 β-TM patients (24 males and 18 females) aged from 3 to 30 years and 36 age- and sex-matched healthy controls...
December 2017: Journal of Ultrasound
https://www.readbyqxmd.com/read/29150290/premature-atherosclerosis-in-premenopausal-women-does-cytokine-balance-play-a-role
#2
Jo-Ann Eastwood, Doris A Taylor, B Delia Johnson, Micheline Resende, Barry L Sharaf, Bina Ahmed, Margo Minissian, Chrisandra Shufelt, Noel Bairey Merz
Contributory risk factors to premature coronary artery disease (CAD) in premenopausal women are poorly understood and data on this subset of women is lacking. There is growing evidence that the process of inflammation is a part of the atherosclerotic process. Mechanistic insights from animal work suggest that the profile of circulating cytokines reflects both endothelial integrity and the presence of immune and progenitor cells. Significant differences in pro- and anti-inflammatory cytokine concentrations between patients with and without CAD exist...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29120587/matrix-metalloproteinase-2-and-osteoprotegrin-as-new-markers-of-increased-atherosclerotic-risk-in-egyptian-patients-with-chronic-kidney-disease
#3
Amany M Elsaeed, Amal H Ibrahiem, Asmaa A Ali
The prevalence of chronic kidney disease (CKD) is rising continuously. Cardiovascular disease (CVD) is among the leading causes of death and premature mortality of patients with CKD. It has been suggested that the assessment of CKD-associated CVD risk factors together with conventional risk factors should be performed in order to improve the prediction of coronary heart disease risk. The reduction of these factors seems to be effective in lowering cardiovascular (CV) morbidity and mortality in patients with CKD...
January 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29118911/fibroblast-growth-factor-21-delayed-endothelial-replicative-senescence-and-protected-cells-from-h2o2-induced-premature-senescence-through-sirt1
#4
Jinhua Yan, Jinli Wang, Huijin Huang, Yi Huang, Tao Mi, Cuntai Zhang, Le Zhang
Vascular aging is an independent risk factor for age-related diseases, including atherosclerosis. Fibroblast growth factor 21 (FGF21) has been widely recognized as a metabolic regulator that is elevated in response to caloric and nutritional restrictions. Recent studies have demonstrated its emerging role as a pro-longevity hormone, but its effects on the senescence of human umbilical vascular endothelial cells (HUVECs) remain unclear. In the present study, we explored the anti-senescence effects and underlying mechanism of FGF21 on HUVECs...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29118461/relationship-between-rs854560-pon1-gene-polymorphism-and-tobacco-smoking-with-coronary-artery-disease
#5
Joanna Iwanicka, Tomasz Iwanicki, Paweł Niemiec, Tomasz Nowak, Jolanta Krauze, Władysław Grzeszczak, Sylwia Górczyńska-Kosiorz, Anna Ochalska-Tyka, Iwona Żak
Paraoxonase-1 (PON1) is the antioxidant marker of high-density lipoproteins protecting against atherosclerosis and coronary artery disease (CAD) phenotype. The purpose of the present study was to determine whether the PON1 gene rs854560 polymorphism (163T>A) is associated with CAD in Polish population. rs854560 was genotyped in 494 subjects: 248 patients with premature CAD and 246 blood donors as a control. We found that the risk of CAD was significantly higher in TT homozygotes than in A allele carriers (OR = 1...
2017: Disease Markers
https://www.readbyqxmd.com/read/29107826/inhibition-of-vascular-smooth-muscle-cells-premature-senescence-with-rutin-attenuates-and-stabilizes-diabetic-atherosclerosis
#6
Yihui Li, Ranran Qin, Hongdan Yan, Feng Wang, Shanying Huang, Yun Zhang, Ming Zhong, Wei Zhang, Zhihao Wang
Atherosclerosis is an age-associated disease; however, diabetic atherosclerosis has higher severity beyond age range for accumulative premature senescent cells in diabetes. Recent findings suggest that rutin, a flavonoid, has potential benefits for diabetic individuals. This study was designed to evaluate the effects of rutin on premature senescence and atherosclerosis. Apolipoprotein E knockout mice exhibiting insulin resistance after 6 weeks of high-fat diet were administered with a low dose of streptozotocin (STZ) to induce diabetes...
September 28, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29106543/survival-in-homozygous-familial-hypercholesterolaemia-is-determined-by-the-on-treatment-level-of-serum-cholesterol
#7
Gilbert R Thompson, Dirk J Blom, A David Marais, Mary Seed, Gillian J Pilcher, Frederick J Raal
Aims: Homozygous familial hypercholesterolaemia (FH) is a rare inherited disorder characterized by extreme hypercholesterolaemia from birth, accelerated atherosclerosis, and premature death. Many forms of lipid-lowering therapies have been used in the past, but definitive evidence of benefit has been lacking. We therefore undertook a retrospective survey of lipid levels and clinical outcomes of FH homozygotes treated with a combination of lipid-lowering measures between 1990 and 2014 in South Africa and the UK...
July 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29099857/knockout-of-apolipoprotein-e-in-rabbit-promotes-premature-intervertebral-disc-degeneration-a-new-in-vivo-model-for-therapeutic-approaches-of-spinal-disc-disorders
#8
Anja Beierfuß, Hermann Dietrich, Christian Kremser, Monika Hunjadi, Andreas Ritsch, Thomas Rülicke, Claudius Thomé, Demissew Shenegelegn Mern
Intervertebral disc (IVD) degeneration that accelerates the loss of disc structural and functional integrities is recognized as one of the major factors of chronic back pain. Cardiovascular risk factors, such as deficits of apolipoproteins that elevate the levels of cholesterol and triglycerides, are considered critical for the progress of atherosclerosis; notably in the abdominal aorta and its lumbar branching arteries that supply lumbar vertebrae and IVDs. Obstruction of the lumbar arteries by atherosclerosis is presumed to promote lumbar disc degeneration and low back pain...
2017: PloS One
https://www.readbyqxmd.com/read/29089446/mir-505-3p-controls-chemokine-receptor-up-regulation-in-macrophages-role-in-familial-hypercholesterolemia
#9
Rafael Escate, Pedro Mata, Jose Maria Cepeda, Teresa Padró, Lina Badimon
Familial hypercholesterolemia (FH) conveys a high risk of premature atherosclerosis as a result of lifelong exposure to high LDL cholesterol levels that are not fully reduced by standard-of-care lipid-lowering treatment. Inflammatory mediators have played a role in the progression of atherosclerotic lesions. Here, we investigated whether innate immunity cells in patients with FH have a specific proinflammatory phenotype that is distinct from that of cells in normal participants. To this end, miR-505-3p-a microRNA related to chronic inflammation-and its target genes were investigated in monocyte-derived macrophages (MACs) of patients with FH (FH-MACs) and non-FH controls (co-MACs)...
October 31, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29059644/resveratrol-has-a-positive-effect-on-parameters-of-central-hemodynamics-and-myocardial-ischemia-in-patients-with-stable-coronary-heart-disease
#10
Nataliya I Chekalina
INTRODUCTION: Cardiovascular diseases, and primarily coronary heart disease (CHD), are the leading cause of mortality in the developing countries, including Ukraine. Prognosis for patients with CHD depends mainly on progression of coronary atherosclerosis (ASVD). Molecular mechanisms of atherogenesis are studied in detail in order to find new targets of pharmacological intervention. THE AIM: to study the effect of resveratrol on parameters of central hemodynamics and myocardial ischemia in patients with stable coronary heart disease (CHD)...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29058952/increased-arterial-stiffness-in-children-with-congenital-heart-disease
#11
Anna-Luisa Häcker, Barbara Reiner, Renate Oberhoffer, Alfred Hager, Peter Ewert, Jan Müller
Objective Central systolic blood pressure (SBP) is a measure of arterial stiffness and strongly associated with atherosclerosis and end-organ damage. It is a stronger predictor of cardiovascular events and all-cause mortality than peripheral SBP. In particular, for children with congenital heart disease, a higher central SBP might impose a greater threat of cardiac damage. The aim of the study was to analyse and compare central SBP in children with congenital heart disease and in healthy counterparts. Patients and methods Central SBP was measured using an oscillometric method in 417 children (38...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29044294/serum-levels-of-anti-pon1-and-anti-hdl-antibodies-as-potential-biomarkers-of-premature-atherosclerosis-in-systemic-lupus-erythematosus
#12
Patricia López, Javier Rodríguez-Carrio, Aleida Martínez-Zapico, Ángel I Pérez-Álvarez, Raquel López-Mejías, Lorena Benavente, Lourdes Mozo Mozo, Luis Caminal-Montero, Miguel A González-Gay, Ana Suárez
The present study aimed to evaluate the possible role of immunoglobulin G (IgG) antibodies against high-density lipoproteins (HDL) and paraoxonase 1 (PON1) as possible biomarkers of cardiovascular disease (CVD) in systemic lupus erythematosus (SLE). To this end, levels of these autoantibodies, PON1 activity and total antioxidant capacity were quantified in serum samples from 198 SLE patients, 100 healthy controls (HC) and 42 non-autoimmune individuals with traditional cardiovascular risk factors. PON1 rs662 polymorphism was analysed in a subgroup of patients and controls...
October 10, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29022506/autologous-cell-therapy-for-vascular-regeneration-the-role-of-proangiogenic-cells
#13
Vanessa Bianconi, Francesca Fallarino, Massimo Raffaele Mannarino, Francesco Bagaglia, Meisam Naeimi Kararoudi, Caterina Oriana Aragona, Rita Romani, Matteo Pirro
Autologous cell therapy represents a novel treatment option for vascular regeneration in different disease conditions. Both experimental and clinical studies indicate a therapeutic potential for different proangiogenic cells (PCs), including endothelial progenitor cells (EPCs) in the treatment of peripheral artery disease. A significant improvement of ischemic symptoms has been reported in different trials evaluating PCs for the treatment of critical limb ischemia. However, contrasting results from different meta-analyses question the efficacy of PC-based approaches on long-term outcomes, including amputation and survival...
October 12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29022266/cardiac-aging-benefits-of-exercise-nrf2-activation-and-antioxidant-signaling
#14
Madhusudhanan Narasimhan, Namakkal-Soorappan Rajasekaran
Cardiovascular dysfunction and heart failure associated with aging not only impairs the cardiac function but also the quality of life eventually decreasing the life expectancy of the elderly. Notably, cardiac tissue can prematurely age under certain conditions such as genetic mutation, persistent redox stress and overload, aberrant molecular signaling, DNA damage, telomere attrition, and other pathological insults. While cardiovascular-related morbidity and mortality is on the rise and remains a global health threat, there has been only little to moderate improvements in its medical management...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29022136/aortic-carotid-intima-media-thickness-and-flow-mediated-dilation-as-markers-of-early-atherosclerosis-in-a-cohort-of-pediatric-patients-with-rheumatic-diseases
#15
Emanuela Del Giudice, Anna Dilillo, Luciana Tromba, Giuseppe La Torre, Sara Blasi, Fabrizio Conti, Franca Viola, Salvatore Cucchiara, Marzia Duse
The aims of this study were to identify the presence of endothelial dysfunction as a marker of early atherosclerosis by measuring aortic and carotid intimal-medial thickness (aIMT and cIMT) and flow-mediated dilation (FMD) and their correlation with traditional and no traditional risk factors for atherosclerosis in children with rheumatic diseases. Thirty-nine patients (mean age 15.3 ± 5.7 years), 23 juvenile idiopathic arthritis, 9 juvenile spondyloarthropathies, 7 connective tissue diseases (mean disease duration and onset respectively 5 ± 3...
October 12, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28988641/sex-dependent-effects-of-diabetes-mellitus-on-the-revascularization-rate-in-mid-term-follow-up-of-young-patients-with-coronary-artery-disease
#16
Masoumeh Lotfi-Tokaldany, Seyed Hesameddinn Abbasi, Abbasali Karimi, Seyed Ebrahim Kassaian, Tahereh Davarpasand, Arash Jalali, Saeed Sadeghian
AIMS: We investigated the association between Type-2 diabetes mellitus (DM) and the need for revascularization at a 5-year follow-up of young coronary artery disease patients and the role of sex in this regard. METHODS: Among 1121 young (males≤45, and females≤55years) patients (female: 49.7%) from Tehran Heart Center's Premature Coronary Atherosclerosis Cohort, 371(33.1%) had diabetes prior to angiography. Revascularization was considered as either percutaneous coronary intervention or coronary artery bypass graft surgery...
December 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28980290/atherosclerosis-in-antineutrophil-cytoplasmic-autoantibody-anca-associated-vasculitis
#17
Katarzyna Życińska, Anna Borowiec
The primary systemic vasculitides are heterogeneous, multisystem disorders characterized by inflammation and necrosis of small and medium blood vessels. Patients with antineutrophil cytoplasmic autoantibodies associated vasculitis have increased mortality rate as a consequence of cardiovascular disease. Measures to reduce the risk of cardiovascular disease should be integral to the management of systemic vasculitis. The preventive therapy for accelerated atherosclerosis in systemic vasculitis should be based on aggressive approach against inflammation and against risk factors of premature atherosclerosis such as hypertension, smoking, inactivity, obesity and unhealthy diet...
October 5, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28972956/does-polycystic-ovary-syndrome-increase-the-risk-of-subclinical-vascular-disease-in-normal-weight-type-1-diabetic-women
#18
Agnieszka Łebkowska, Agnieszka Adamska, Małgorzata Jacewicz, Joanna Tołwińska, Anna Krentowska, Justyna Hryniewicka, Monika Leśniewska, Artur Bossowski, Maria Górska, Irina Kowalska
INTRODUCTION The prevalence of polycystic ovary syndrome (PCOS) among type 1 diabetic women (T1DM) is higher than in general population. Both diseases are associated with higher risk of premature atherosclerosis. OBJECTIVES The aim of our study was to evaluate whether the cardiovascular risks conferred by T1DM and PCOS are additive. PATIENTS AND METHODS The study group included seventy-eight women divided into 4 groups: 19 women with PCOS and T1DM (T1DM+PCOS), 16 women with T1DM only (T1DM/no-PCOS), 27 women with PCOS only (PCOS), and 16 healthy women (control group)...
September 30, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28969085/interleukin-27-polymorphisms-are-associated-with-premature-coronary-artery-disease-and-metabolic-parameters-in-the-mexican-population-the-genetics-of-atherosclerotic-disease-gea-mexican-study
#19
Rosalinda Posadas-Sánchez, Nonanzit Pérez-Hernández, José Manuel Rodríguez-Pérez, Ramón M Coral-Vázquez, Bladimir Roque-Ramírez, Luis Llorente, Guadalupe Lima, Carmina Flores-Dominguez, Teresa Villarreal-Molina, Carlos Posadas-Romero, Gilberto Vargas-Alarcón
Several studies suggest an important role of Interleukin-27 in the development of atherosclerosis. The aim of this study was to establish whether the IL-27p28 gene polymorphisms are associated with premature coronary artery disease and/or other cardiovascular risk factors. Four IL-27p28 gene polymorphisms were selected and genotyped in 1162 premature coronary artery disease cases and 1107 controls. rs26528 T and rs40837 A alleles were significantly associated with a lower risk of premature coronary artery disease under different inheritance models (Pdominant = 0...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28965615/familial-hypercholesterolemia-the-italian-atherosclerosis-society-network-lipigen
#20
Maurizio Averna, Angelo B Cefalù, Manuela Casula, Davide Noto, Marcello Arca, Stefano Bertolini, Sebastiano Calandra, Alberico L Catapano, Patrizia Tarugi
BACKGROUND AND AIMS: Primary dyslipidemias are a heterogeneous group of disorders characterized by abnormal levels of circulating lipoproteins. Among them, familial hypercholesterolemia is the most common lipid disorder that predisposes for premature cardiovascular disease. We set up an Italian nationwide network aimed at facilitating the clinical and genetic diagnosis of genetic dyslipidemias named LIPIGEN (LIpid TransPort Disorders Italian GEnetic Network). METHODS: Observational, multicenter, retrospective and prospective study involving about 40 Italian clinical centers...
October 2017: Atherosclerosis. Supplements
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