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premature atherosclerosis

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https://www.readbyqxmd.com/read/28321150/interleukin-35-polymorphisms-are-associated-with-decreased-risk-of-premature-coronary-artery-disease-metabolic-parameters-and-il-35-levels-the-genetics-of-atherosclerotic-disease-gea-study
#1
Rosalinda Posadas-Sánchez, Nonanzit Pérez-Hernández, Javier Angeles-Martínez, Fabiola López-Bautista, Teresa Villarreal-Molina, José Manuel Rodríguez-Pérez, José Manuel Fragoso, Carlos Posadas-Romero, Gilberto Vargas-Alarcón
Interleukin 35 (IL-35) is a heterodimeric cytokine involved in the development of atherosclerosis. The aim of the present study was to establish if the polymorphisms of IL-12A and EBI3 genes that encode the IL-35 subunits are associated with the development of premature coronary artery disease (CAD) in Mexican individuals. The IL-12A and EBI3 polymorphisms were determined in 1162 patients with premature CAD and 873 controls. Under different models, the EBI3 rs428253 (OR = 0.831, Padd = 0.036; OR = 0.614, Prec = 0...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28302025/the-use-of-plant-sterols-and-stanols-as-lipid-lowering-agents-in-cardiovascular-disease
#2
Jacek Rysz, Beata Franczyk, Robert Olszewski, Maciej Banach, Anna Gluba-Brzózka
BACKGROUND: The prevalence of premature atherosclerosis and cardiovascular disease (CVD) is constantly increasing worldwide. It has been proved that LDL-cholesterol (LDL-C) plays causal role in the development of coronary atherosclerosis. The fact that atherosclerosis is a chronic and progressive disease which onsets during the first three decades of life bores questions what to do to maintain LDL-C at low levels throughout life and thus to delay and/or prevent the progress this disease...
March 16, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28290995/uses-of-polypills-for-cardiovascular-disease-and-evidence-to-date
#3
REVIEW
Mark D Huffman, Denis Xavier, Pablo Perel
Polypills have been approved in more than 30 countries, but worldwide experience with and availability of polypills remain limited, unlike fixed-dose combinations in other diseases such as HIV, tuberculosis, and malaria. In this Series review, we aim to propose a guide for the use of polypills in future research and clinical activities and to synthesise contemporary evidence supporting the use of polypills for prevention of atherosclerosis. Polypill uses can be categorised by population and indication, both of which influence the balance between benefits and risks...
March 11, 2017: Lancet
https://www.readbyqxmd.com/read/28279217/hypofibrinolysis-in-diabetes-a-therapeutic-target-for-the-reduction-of-cardiovascular-risk
#4
REVIEW
Katherine Kearney, Darren Tomlinson, Kerrie Smith, Ramzi Ajjan
An enhanced thrombotic environment and premature atherosclerosis are key factors for the increased cardiovascular risk in diabetes. The occlusive vascular thrombus, formed secondary to interactions between platelets and coagulation proteins, is composed of a skeleton of fibrin fibres with cellular elements embedded in this network. Diabetes is characterised by quantitative and qualitative changes in coagulation proteins, which collectively increase resistance to fibrinolysis, consequently augmenting thrombosis risk...
March 9, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28279156/premature-atherosclerosis-in-children-with-beta-thalassemia-major-new-diagnostic-marker
#5
Laila M Sherief, Osama Dawood, Adel Ali, Hanan S Sherbiny, Naglaa M Kamal, Mohamed Elshanshory, Osama Abd Alazez, Mohamed Abd Alhady, Mohamed Nour, Wesam A Mokhtar
BACKGROUND: Early vascular alteration, atherosclerosis and coronary artery disease have emerged as important cardiovascular complications among beta-thalassemia major (B-TM) patients. The aims of the current study were to assess the prevalence of premature atherosclerosis among our B-TM patients, and to investigate the diagnostic value of serum Osteoprotegerin assay as an early biomarker for atherosclerosis. METHODS: This cross-sectional study was conducted at Hematology unit - Pediatric Department, Zagazig University Children Hospital- Egypt in the period from March 2014 to March 2015...
March 9, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28249844/cardiovascular-disease-and-patterns-of-change-in-functional-status-over-15%C3%A2-years-findings-from-the-atherosclerosis-risk-in-communities-aric-study
#6
Anna Kucharska-Newton, Michael Griswold, Zhihao Howard Yao, Randi Foraker, Kathryn Rose, Wayne Rosamond, Lynne Wagenknecht, Silvia Koton, Lisa Pompeii, B Gwen Windham
BACKGROUND: Cardiovascular disease (CVD) is the leading cause of premature disability, yet few prospective studies have examined functional status (FS) among persons with CVD. Our aim was to examine patterns of change in FS prior to and after hospitalization for nonfatal myocardial infarction, stroke, and heart failure among members of the Atherosclerosis Risk in Communities (ARIC) study cohort. METHODS AND RESULTS: FS was assessed using a modified Rosow-Breslau questionnaire administered during routine annual telephone interviews conducted from 1993 through 2007 among 15 277 ARIC study participants...
March 1, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28205331/new-insights-to-the-mechanisms-underlying-atherosclerosis-in-rheumatoid-arthritis
#7
REVIEW
Mahdi Mahmoudi, Saeed Aslani, Reza Fadaei, Ahmad Reza Jamshidi
Rheumatoid arthritis (RA) is an inflammatory circumstance, which has been associated with increased risk of cardiovascular disease (CVD). Although RA management has been promoted, mortality rate due to CVD remains remarkable. Approximately, 50% of premature death cases in RA are attributable to CVD. RA patients develop atherosclerosis in a greater amount than the general population. Moreover, atherosclerotic lesions develop rapidly in RA patients and might be more susceptible to rupture. The inflammatory condition of RA, such as cytokines, abnormally activated immune cells, play a role in the initiation, perpetuation and exacerbation of atherosclerosis...
February 16, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28203044/a-case-of-sitosterolemia-due-to-compound-heterozygous-mutations-in-abcg5-clinical-features-and-treatment-outcomes-obtained-with-colestimide-and-ezetimibe
#8
Sahoko Ono, Junko Matsuda, Aki Saito, Takenobu Yamamoto, Wataru Fujimoto, Hitomi Shimizu, Sumito Dateki, Kazunobu Ouchi
Sitosterolemia is a rare, autosomal recessively inherited disorder of lipid metabolism caused by mutations in the "ATP-binding cassette, subfamily G" member 5 and 8 proteins (encoded by the ABCG5 and ABCG8 genes, respectively), which play critical roles in the intestinal and biliary excretion of plant sterols. We report the clinical features and treatment outcomes of an 18-month-old Japanese girl with sitosterolemia, who presented with multiple linear and intertriginous xanthomas around the joint areas. Serum lipid analyses revealed elevated levels of total cholesterol (T-Chol: 866 mg/dL), low density lipoprotein-cholesterol (LDL-C: 679 mg/dL), and plant sterols (sitosterol: 24...
January 2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/28168401/dyslipidemia-in-systemic-lupus-erythematosus
#9
Melinda Zsuzsanna Szabó, Peter Szodoray, Emese Kiss
Cardiovascular disease is one of the major causes of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Accelerated atherosclerosis is related to traditional (age, hypertension, diabetes mellitus, dyslipidemia, obesity, smoking, and positive family history) and non-traditional, disease-related factors. Traditional risk factors are still more prominent in patients with lupus, as both hypertension and hypercholesterinemia were independently associated with premature atherosclerosis in several SLE cohorts...
February 7, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28166531/challenges-in-the-cross-sectional-assessment-of-cardiovascular-risk-in-children-with-premature-adrenarche-due-to-the-multifaceted-nature-of-atherosclerosis%C3%A2
#10
Ahmet Uçar
No abstract text is available yet for this article.
February 6, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28131047/long-term-outcome-in-53-patients-with-homozygous-familial-hypercholesterolaemia-in-a-single-centre-in-france
#11
Eric Bruckert, Olga Kalmykova, Randa Bittar, Valérie Carreau, Sophie Béliard, Samir Saheb, David Rosenbaum, Dominique Bonnefont-Rousselot, Daniel Thomas, Corinne Emery, Babak Khoshnood, Alain Carrié
BACKGROUND AND AIMS: Homozygous familial hypercholesterolaemia (HoFH) is a rare inherited condition characterized by elevated plasma low-density lipoprotein-cholesterol (LDL-C) levels, severe, accelerated atherosclerosis and premature coronary heart disease. We evaluated cardiovascular complications in HoFH patients over extended follow-up and investigated their association with changes in cholesterol over time, as well as total cholesterol burden. METHODS: In this retrospective single-centre study, 53 patients (baseline mean ± standard deviation [SD], total cholesterol 15...
February 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28123161/estimated-prevalence-of-heterozygous-familial-hypercholesterolemia-in-patients-with-acute-coronary-syndrome
#12
Hirotoshi Ohmura, Yoshifumi Fukushima, Atsushi Mizuno, Koichiro Niwa, Yohei Kobayashi, Toshiaki Ebina, Kazuo Kimura, Shun Ishibashi, Hiroyuki Daida
Heterozygous familial hypercholesterolemia (FH) represents a strong risk for development of premature coronary artery disease (CAD). However, the majority of patients with FH are undiagnosed and the prevalence likely represents an underestimate in most countries. In Japan, the possible contribution of FH to the development of CAD may be higher because of the low incidence of CAD among the general population. We estimated the prevalence of heterozygous FH by measuring Achilles tendon thickness (ATT) in patients with acute coronary syndrome (ACS)...
February 7, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28097840/assessment-of-lipid-profile-and-some-risk-factors-of-atherosclerosis-in-children-whose-parents-had-early-onset-coronary-artery-disease
#13
Helen Bornaun, Naci Öner, Kemal Nişli, Kazım Öztarhan, Taner Yavuz, Ümit Türkoğlu, Aygün Dindar, Rukiye Eker Ömeroglu
BACKGROUND/AIM: The objective of our study was to analyze the lipid profile and some risk factors of atherosclerosis such as oxidized-low density lipoprotein (ox-LDL), small dense LDL (sd LDL) in the offspring of patients with premature coronary heart disease (CHD). POPULATION AND METHODS: Children whose parents had early onset CHD were matched with age and sex pairs. Study and controls were analyzed for lipid levels, apolipoproteins (Apo- A,B,E), ox-LDL, sd LDL and lipoprotein (a) [Lp(a)]...
February 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28093682/association-between-ischemic-heart-disease-and-systemic-lupus-erythematosus-a-large-case-control-study
#14
Abdulla Watad, Arsalan Abu Much, Danielle Bracco, Naim Mahroum, Doron Comaneshter, Arnon D Cohen, Howard Amital
Ischemic heart disease (IHD) is a well identified cause of mortality in systemic lupus erythematosus (SLE) patients due to an accelerated premature atherosclerosis. We investigated the proportion of comorbid IHD among SLE patients derived from a large, national real-life database. Using data from the largest HMO in Israel, the Clalit Health Services, we selected for patients with SLE. These patients were compared with age and sex matched controls with regards to the proportion of IHD in a case-control study...
January 17, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28088517/osborne-mendel-rats-simultaneously-develop-cardiac-and-renal-dysfunction-left-atrial-thrombosis-peripheral-artery-occlusion-and-ascending-aortic-dissection
#15
Makoto Asahina, Hideki Matsumoto, Yoshitaka Yasuhara, Noriko Suzuki, Ritsuko Takami, Michiyasu Takeyama, Ryuichi Tozawa
Although chronic kidney disease (CKD) is strongly associated with onsets of cardiovascular disease (CVD), the pathogenic mechanism between these diseases has not been fully understood. To develop and validate new therapeutic strategies for this complication, appropriate experimental models that reflect the complexity of the underlying pathophysiology are needed. The Osborne-Mendel (OM) rat was identified as an atherosclerosis-prone and a premature-death rat strain among 16 inbred rat strains when fed high-cholesterol containing diet...
April 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28058808/repeatability-of-ectopic-beats-from-48-hr-ambulatory-electrocardiography-the-atherosclerosis-risk-in-communities-aric-study
#16
Michelle L Meyer, Elsayed Z Soliman, Lisa M Wruck, Thomas H Mosley, Lynne E Wagenknecht, Anna K Poon, Eric A Whitsel, Alvaro Alonso, Gerardo Heiss, Laura R Loehr
BACKGROUND: The purpose of this study was to characterize the repeatability of ectopic beats, defined by premature atrial contractions (PACs) and premature ventricular contractions (PVCs), on ambulatory electrocardiogram (aECG) monitoring and evaluate the effect of length of aECG monitoring on the repeatability estimates. METHODS: This analysis includes 95 randomly selected participants from the Atherosclerosis Risk in Communities Study (ARIC; 2011-2013). The participants wore a Holter monitor for two, 48-hr periods separated by a mean of 38 days following an identical, standardized protocol...
January 6, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28052405/myocardial-layer-specific-analysis-in-patients-with-heterozygous-familial-hypercholesterolemia-using-speckle-tracking-echocardiography
#17
Zhaoting Leng, Rongjuan Li, Yijia Li, Lvya Wang, Yueli Wang, Ya Yang
OBJECTIVE: Familial hypercholesterolemia (FH) is the most common and serious monogenic disorder of lipid metabolism, causing premature coronary heart disease (CHD) due to accelerated atherosclerosis from birth, and the study of left ventricular (LV) function of this disease is seldom. The purpose of this study was to explore the value of layer-specific strain on assessing the early damage of LV function in asymptomatic and left ventricular ejection fraction (LVEF) well-preserved patients with heterozygous FH (HeFH)...
March 2017: Echocardiography
https://www.readbyqxmd.com/read/28052272/ischemic-stroke-in-young-adults-of-northern-china-characteristics-and-risk-factors-for-recurrence
#18
Fang Li, Li Yang, Rui Yang, Wei Xu, Fu-Ping Chen, Nan Li, Jin-Biao Zhang
BACKGROUND: Young adults accounted for 10-14% of ischemic stroke patients. The risk factors may differ in this population from elder patients. In addition, the factors associated with stroke recurrence in this population have not been well investigated. OBJECTIVE: The study aimed to investigate the characteristics and risk factors associated with recurrence of ischemic stroke in young adults. METHODS: Clinical data of 1,395 patients of age 18-45 years who were treated between 2008 and 2014 in 3 centers located in northern China was reviewed...
2017: European Neurology
https://www.readbyqxmd.com/read/28050181/factors-associated-with-depressive-symptoms-in-young-adults-with-coronary-artery-disease-tehran-heart-center-s-premature-coronary-atherosclerosis-cohort-thc-pac-study
#19
Seyed Hesameddin Abbasi, Seyed Ebrahim Kassaian, Saeed Sadeghian, Abbasali Karimi, Soheil Saadat, Flora Peyvandi, Arash Jalali, Tahereh Davarpasand, Shahin Akhondzadh, Nazila Shahmansouri, Masoumeh Lotfi-Tokaldany, Maryam Amiri Abchouyeh, Farah Ayatollahzade Isfahani, Frits Rosendaal
Objective: Depressed coronary artery disease (CAD) patients may experience a poorer prognosis than non-depressed patients. The aim of this study was to find the associated factors for depressive symptoms in young adults with CAD. Method: This was a cross-sectional study within Tehran Heart Center's Premature Coronary Atherosclerosis Cohort (THC-PAC) study. Young adult CAD patients (men ≤ 45 year-old and women ≤ 55 year-old) were visited from March 2013 to February 2014. Demographic, clinical and laboratory data were collected and all patients were asked to fill in the Beck Depression Inventory II...
October 2016: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/28045034/premature-senescence-of-endothelial-cells-upon-chronic-exposure-to-tnf%C3%AE-can-be-prevented-by-n-acetyl-cysteine-and-plumericin
#20
Shafaat Y Khan, Ezzat M Awad, Andre Oszwald, Manuel Mayr, Xiaoke Yin, Birgit Waltenberger, Hermann Stuppner, Markus Lipovac, Pavel Uhrin, Johannes M Breuss
Cellular senescence is characterized by a permanent cell-cycle arrest and a pro-inflammatory secretory phenotype, and can be induced by a variety of stimuli, including ionizing radiation, oxidative stress, and inflammation. In endothelial cells, this phenomenon might contribute to vascular disease. Plasma levels of the inflammatory cytokine tumor necrosis factor alpha (TNFα) are increased in age-related and chronic conditions such as atherosclerosis, rheumatoid arthritis, psoriasis, and Crohn's disease. Although TNFα is a known activator of the central inflammatory mediator NF-κB, and can induce the intracellular generation of reactive oxygen species (ROS), the question whether TNFα can induce senescence has not been answered conclusively...
January 3, 2017: Scientific Reports
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