keyword
MENU ▼
Read by QxMD icon Read
search

premature atherosclerosis

keyword
https://www.readbyqxmd.com/read/29044294/serum-levels-of-anti-pon1-and-anti-hdl-antibodies-as-potential-biomarkers-of-premature-atherosclerosis-in-systemic-lupus-erythematosus
#1
Patricia López, Javier Rodríguez-Carrio, Aleida Martínez-Zapico, Ángel I Pérez-Álvarez, Raquel López-Mejías, Lorena Benavente, Lourdes Mozo Mozo, Luis Caminal-Montero, Miguel A González-Gay, Ana Suárez
The present study aimed to evaluate the possible role of immunoglobulin G (IgG) antibodies against high-density lipoproteins (HDL) and paraoxonase 1 (PON1) as possible biomarkers of cardiovascular disease (CVD) in systemic lupus erythematosus (SLE). To this end, levels of these autoantibodies, PON1 activity and total antioxidant capacity were quantified in serum samples from 198 SLE patients, 100 healthy controls (HC) and 42 non-autoimmune individuals with traditional cardiovascular risk factors. PON1 rs662 polymorphism was analysed in a subgroup of patients and controls...
October 10, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29022506/autologous-cell-therapy-for-vascular-regeneration-the-role-of-proangiogenic-cells
#2
Vanessa Bianconi, Francesca Fallarino, Massimo Raffaele Mannarino, Francesco Bagaglia, Meisam Naeimi Kararoudi, Caterina Oriana Aragona, Rita Romani, Matteo Pirro
Autologous cell therapy represents a novel treatment option for vascular regeneration in different disease conditions. Both experimental and clinical studies indicate a therapeutic potential for different proangiogenic cells (PCs), including endothelial progenitor cells (EPCs) in the treatment of peripheral artery disease. A significant improvement of ischemic symptoms has been reported in different trials evaluating PCs for the treatment of critical limb ischemia. However, contrasting results from different meta-analyses question the efficacy of PC-based approaches on long-term outcomes, including amputation and survival...
October 12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29022266/cardiac-aging-benefits-of-exercise-nrf2-activation-and-antioxidant-signaling
#3
Madhusudhanan Narasimhan, Namakkal-Soorappan Rajasekaran
Cardiovascular dysfunction and heart failure associated with aging not only impairs the cardiac function but also the quality of life eventually decreasing the life expectancy of the elderly. Notably, cardiac tissue can prematurely age under certain conditions such as genetic mutation, persistent redox stress and overload, aberrant molecular signaling, DNA damage, telomere attrition, and other pathological insults. While cardiovascular-related morbidity and mortality is on the rise and remains a global health threat, there has been only little to moderate improvements in its medical management...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29022136/aortic-carotid-intima-media-thickness-and-flow-mediated-dilation-as-markers-of-early-atherosclerosis-in-a-cohort-of-pediatric-patients-with-rheumatic-diseases
#4
Emanuela Del Giudice, Anna Dilillo, Luciana Tromba, Giuseppe La Torre, Sara Blasi, Fabrizio Conti, Franca Viola, Salvatore Cucchiara, Marzia Duse
The aims of this study were to identify the presence of endothelial dysfunction as a marker of early atherosclerosis by measuring aortic and carotid intimal-medial thickness (aIMT and cIMT) and flow-mediated dilation (FMD) and their correlation with traditional and no traditional risk factors for atherosclerosis in children with rheumatic diseases. Thirty-nine patients (mean age 15.3 ± 5.7 years), 23 juvenile idiopathic arthritis, 9 juvenile spondyloarthropathies, 7 connective tissue diseases (mean disease duration and onset respectively 5 ± 3...
October 12, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28988641/sex-dependent-effects-of-diabetes-mellitus-on-the-revascularization-rate-in-mid-term-follow-up-of-young-patients-with-coronary-artery-disease
#5
Masoumeh Lotfi-Tokaldany, Seyed Hesameddinn Abbasi, Abbasali Karimi, Seyed Ebrahim Kassaian, Tahereh Davarpasand, Arash Jalali, Saeed Sadeghian
AIMS: We investigated the association between Type-2 diabetes mellitus (DM) and the need for revascularization at a 5-year follow-up of young coronary artery disease patients and the role of sex in this regard. METHODS: Among 1121 young (males≤45, and females≤55years) patients (female: 49.7%) from Tehran Heart Center's Premature Coronary Atherosclerosis Cohort, 371(33.1%) had diabetes prior to angiography. Revascularization was considered as either percutaneous coronary intervention or coronary artery bypass graft surgery...
July 4, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28980290/atherosclerosis-in-antineutrophil-cytoplasmic-autoantibody-anca-associated-vasculitis
#6
Katarzyna Życińska, Anna Borowiec
The primary systemic vasculitides are heterogeneous, multisystem disorders characterized by inflammation and necrosis of small and medium blood vessels. Patients with antineutrophil cytoplasmic autoantibodies associated vasculitis have increased mortality rate as a consequence of cardiovascular disease. Measures to reduce the risk of cardiovascular disease should be integral to the management of systemic vasculitis. The preventive therapy for accelerated atherosclerosis in systemic vasculitis should be based on aggressive approach against inflammation and against risk factors of premature atherosclerosis such as hypertension, smoking, inactivity, obesity and unhealthy diet...
October 5, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28972956/does-polycystic-ovary-syndrome-increase-the-risk-of-subclinical-vascular-disease-in-normal-weight-type-1-diabetic-women
#7
Agnieszka Łebkowska, Agnieszka Adamska, Małgorzata Jacewicz, Joanna Tołwińska, Anna Krentowska, Justyna Hryniewicka, Monika Leśniewska, Artur Bossowski, Maria Górska, Irina Kowalska
INTRODUCTION The prevalence of polycystic ovary syndrome (PCOS) among type 1 diabetic women (T1DM) is higher than in general population. Both diseases are associated with higher risk of premature atherosclerosis. OBJECTIVES The aim of our study was to evaluate whether the cardiovascular risks conferred by T1DM and PCOS are additive. PATIENTS AND METHODS The study group included seventy-eight women divided into 4 groups: 19 women with PCOS and T1DM (T1DM+PCOS), 16 women with T1DM only (T1DM/no-PCOS), 27 women with PCOS only (PCOS), and 16 healthy women (control group)...
September 30, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28969085/interleukin-27-polymorphisms-are-associated-with-premature-coronary-artery-disease-and-metabolic-parameters-in-the-mexican-population-the-genetics-of-atherosclerotic-disease-gea-mexican-study
#8
Rosalinda Posadas-Sánchez, Nonanzit Pérez-Hernández, José Manuel Rodríguez-Pérez, Ramón M Coral-Vázquez, Bladimir Roque-Ramírez, Luis Llorente, Guadalupe Lima, Carmina Flores-Dominguez, Teresa Villarreal-Molina, Carlos Posadas-Romero, Gilberto Vargas-Alarcón
Several studies suggest an important role of Interleukin-27 in the development of atherosclerosis. The aim of this study was to establish whether the IL-27p28 gene polymorphisms are associated with premature coronary artery disease and/or other cardiovascular risk factors. Four IL-27p28 gene polymorphisms were selected and genotyped in 1162 premature coronary artery disease cases and 1107 controls. rs26528 T and rs40837 A alleles were significantly associated with a lower risk of premature coronary artery disease under different inheritance models (Pdominant = 0...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28965615/familial-hypercholesterolemia-the-italian-atherosclerosis-society-network-lipigen
#9
Maurizio Averna, Angelo B Cefalù, Manuela Casula, Davide Noto, Marcello Arca, Stefano Bertolini, Sebastiano Calandra, Alberico L Catapano, Patrizia Tarugi
BACKGROUND AND AIMS: Primary dyslipidemias are a heterogeneous group of disorders characterized by abnormal levels of circulating lipoproteins. Among them, familial hypercholesterolemia is the most common lipid disorder that predisposes for premature cardiovascular disease. We set up an Italian nationwide network aimed at facilitating the clinical and genetic diagnosis of genetic dyslipidemias named LIPIGEN (LIpid TransPort Disorders Italian GEnetic Network). METHODS: Observational, multicenter, retrospective and prospective study involving about 40 Italian clinical centers...
October 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/28963918/comprehensive-lipid-and-metabolite-profiling-of-children-with-and-without-familial-hypercholesterolemia-a-cross-sectional-study
#10
Jacob J Christensen, Stine M Ulven, Kjetil Retterstøl, Ingunn Narverud, Martin P Bogsrud, Tore Henriksen, Jens Bollerslev, Bente Halvorsen, Pål Aukrust, Kirsten B Holven
BACKGROUND AND AIMS: Individuals with familial hypercholesterolemia (FH) have elevated low-density lipoprotein cholesterol (LDL-C), accelerated atherosclerosis, and premature cardiovascular disease. Whereas children with lifestyle-induced dyslipidemias often present with complex lipid abnormalities, children with FH have isolated hypercholesterolemia. However, to the best of our knowledge, a comprehensive profiling of FH children is lacking. Therefore, we aimed to characterize the lipid-related and metabolic alterations associated with elevated LDL-C in children with FH and healthy children...
September 21, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28941610/scavenger-receptor-lox1-genotype-predicts-coronary-artery-disease-in-patients-with-familial-hypercholesterolemia
#11
Martine Paquette, Robert Dufour, Alexis Baass
BACKGROUND: Familial hypercholesterolemia (FH) is a monogenic disease associated with elevated low-density lipoprotein (LDL) cholesterol and oxidized LDL (oxLDL) leading to premature cardiovascular disease. Lectin-like oxLDL receptor-1 (LOX1) is one of the major contributors of oxLDL uptake and degradation in macrophages, which leads to foam cell formation and the development of atherosclerosis. This study investigated the effect of the rs11053646 genotype of the oxidized low-density lipoprotein receptor 1 (OLR1) gene on coronary artery disease (CAD) risk in a cohort of FH patients...
October 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28934587/aging-in-the-cardiovascular-system-lessons-from-hutchinson-gilford-progeria-syndrome
#12
Magda R Hamczyk, Lara Del Campo, Vicente Andrés
Aging, the main risk factor for cardiovascular disease (CVD), is becoming progressively more prevalent in our societies. A better understanding of how aging promotes CVD is therefore urgently needed to develop new strategies to reduce disease burden. Atherosclerosis and heart failure contribute significantly to age-associated CVD-related morbimortality. CVD and aging are both accelerated in patients suffering from Hutchinson-Gilford progeria syndrome (HGPS), a rare genetic disorder caused by the prelamin A mutant progerin...
September 20, 2017: Annual Review of Physiology
https://www.readbyqxmd.com/read/28932625/vascular-aging-implications-for-cardiovascular-disease-and-therapy
#13
Yohannes T Ghebre, Eduard Yakubov, Wing Tak Wong, Prasanna Krishnamurthy, Nazish Sayed, Andrew G Sikora, Mark D Bonnen
The incidence and prevalence of cardiovascular disease is highest among the elderly, in part, due to deleterious effects of advancing age on the heart and blood vessels. Aging, a known cardiovascular risk factor, is progressively associated with structural and functional changes to the vasculature including hemodynamic disturbance due to increased oxidative stress, premature cellular senescence and impairments in synthesis and/or secretion of endothelium-derived vasoactive molecules. These molecular and physiological changes lead to vessel wall stiffening and thickening, as well as other vascular complications that culminate to loss of vascular tone regulation and endothelial function...
December 2016: Translational Medicine: Current Research
https://www.readbyqxmd.com/read/28910789/end-stage-renal-disease-inflammation-and-cardiovascular-outcomes
#14
Lu Dai, Edyta Golembiewska, Bengt Lindholm, Peter Stenvinkel
Despite marked improvements in renal replacement therapy during the last 30 years, the age-adjusted mortality rate in end-stage renal disease (ESRD) patients is still unacceptably high and comparable to that of many malignancies. Cardiovascular disease (CVD) remains the major cause of morbidity and mortality in ESRD patients. However, traditional risk factors can only partially explain the high premature cardiovascular burden in this population. Nontraditional risk factors, including persistent low-grade inflammation, are critical in the pathogenesis of atherosclerosis, vascular calcification, and other causes of CVD and may also contribute to protein-energy wasting and other complications in chronic kidney disease (CKD) patients...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/28910310/gugulipid-causes-hypercholesterolemia-leading-to-endothelial-dysfunction-increased-atherosclerosis-and-premature-death-by-ischemic-heart-disease-in-male-mice
#15
Andrea Leiva, Susana Contreras-Duarte, Ludwig Amigo, Esteban Sepúlveda, Mauricio Boric, Verónica Quiñones, Dolores Busso, Attilio Rigotti
For proper cholesterol metabolism, normal expression and function of scavenger receptor class B type I (SR-BI), a high-density lipoprotein (HDL) receptor, is required. Among the factors that regulate overall cholesterol homeostasis and HDL metabolism, the nuclear farnesoid X receptor plays an important role. Guggulsterone, a bioactive compound present in the natural product gugulipid, is an antagonist of this receptor. This natural product is widely used globally as a natural lipid-lowering agent, although its anti-atherogenic cardiovascular benefit in animal models or humans is unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28892468/association-between-oxidative-stress-and-peripheral-leukocyte-telomere-length-in-patients-with-premature-coronary-artery-disease
#16
Ran Tian, Lei-Nan Zhang, Ting-Ting Zhang, Hai-Yu Pang, Lian-Feng Chen, Zhu-Jun Shen, Zhenyu Liu, Quan Fang, Shu-Yang Zhang
BACKGROUND Leukocyte telomere length (LTL) is regarded as a potential marker of biological aging. Oxidative stress plays a major role in the rate of telomeric DNA loss. The aim of this study was to explore whether the LTL was shorter in Chinese patients with premature coronary artery disease (PCAD) than in non-CAD controls and to determine the relationship between oxidative stress and LTL shortening in this population. MATERIAL AND METHODS Patients for coronary angiography were recruited. In total, 128 patients with PCAD and 128 non-CAD controls were enrolled...
September 11, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28866363/effects-of-apolipoprotein-m-in-uremic-atherosclerosis
#17
Markus Høybye Bosteen, Eva Martha Madsen Svarrer, Line Stattau Bisgaard, Torben Martinussen, Marie Madsen, Lars Bo Nielsen, Christina Christoffersen, Tanja Xenia Pedersen
BACKGROUND AND AIMS: Chronic kidney disease is characterized by uremia and causes premature death, partly due to accelerated atherosclerosis. Apolipoprotein (apo) M is a plasma carrier protein for the lipid sphingosine-1-phosphate (S1P). The Apom-S1P complex associates with HDL, and may contribute to its anti-atherosclerotic effects. The role of Apom/S1P in atherosclerosis is presently controversial and has not been explored in a uremic setting. We aimed to explore whether plasma concentrations of Apom/S1P are altered by uremia and whether Apom overexpression or deficiency affects classical and uremic atherosclerosis...
August 18, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28836617/hypertension-as-a-cardiovascular-risk-factor-in-autoimmune-rheumatic-diseases
#18
REVIEW
Elena Bartoloni, Alessia Alunno, Roberto Gerli
Evidence for the increased risk of cardiovascular morbidity and mortality in patients with chronic inflammatory and systemic autoimmune diseases has accumulated during the past 15 years. In these patients, an interplay between several mechanisms, including premature acceleration of subclinical atherosclerotic damage, inflammation, and dysregulation of the immune system, is involved in the induction and progression of atherosclerosis. Moreover, traditional cardiovascular risk factors are also likely to contribute, at least in part, to the excess cardiovascular risk...
August 24, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28828022/c1019t-polymorphism-in-the-connexin-37-gene-and-myocardial-infarction-risk-in-premature-coronary-artery-disease
#19
Mehrdad Sheikhvatan, Mohammadali Boroumand, Mehrdad Behmanesh, Seyed Hesameddin Abbasi, Gholamreza Davoodi, Shayan Ziaee, Sara Cheraghi
Background: The C1019T polymorphism of the connexin-37 (GJA4) gene is a single-nucleotide polymorphisms involved in atherosclerotic plaque rupture and atherosclerosis predisposition. We examined the association between the C1019T polymorphism of the GJA4 gene and the occurrence of myocardial infarction (MI) in patients with premature coronary artery disease (CAD). Methods: Our study recruited 1000 patients with the final diagnosis of premature CAD and classified them into 2 groups: with a history of MI (n = 461) and without it (n = 539)...
April 2017: Journal of Tehran Heart Center
https://www.readbyqxmd.com/read/28814891/diabetes-and-dyslipidemia-characterizing-lipoprotein-metabolism
#20
REVIEW
G H Tomkin, D Owens
Premature atherosclerosis in diabetes accounts for much of the decreased life span. New treatments have reduced this risk considerably. This review explores the relationship among the disturbances in glucose, lipid, and bile salt metabolic pathways that occur in diabetes. In particular, excess nutrient intake and starvation have major metabolic effects, which have allowed us new insights into the disturbance that occurs in diabetes. Metabolic regulators such as the forkhead transcription factors, the farnesyl X transcription factors, and the fibroblast growth factors have become important players in our understanding of the dysregulation of metabolism in diabetes and overnutrition...
2017: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
keyword
keyword
19730
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"