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Mahsa Dabagh, Payman Jalali, Peter J Butler, Amanda Randles, John M Tarbell
Local haemodynamics are linked to the non-uniform distribution of atherosclerosic lesions in arteries. Low and oscillatory (reversing in the axial flow direction) wall shear stress (WSS) induce inflammatory responses in endothelial cells (ECs) mediating disease localization. The objective of this study is to investigate computationally how the flow direction (reflected in WSS variation on the EC surface over time) influences the forces experienced by structural components of ECs that are believed to play important roles in mechanotransduction...
May 2017: Journal of the Royal Society, Interface
Peter A Rosenthal, Katherine C Lundy, Dino P Massoglia, Elizabeth H Payne, Gregory Gilbert, Mulugeta Gebregziabher
BACKGROUND: Incidental paranasal sinusitis (IPS) is common on imaging for non-sinusitis disorders, usually without symptoms or obstructive features, and possibly arising from periodontitis (PD). PD associations with atherosclerosis have been widely reported. We test if IPS may also be associated with atherosclerosis. METHODS: IPS was scored retrospectively in a random sample of 180 magnetic resonance (MR) brain scans and compared with chart review for atherosclerosis (all subtypes), rhinosinusitis, and related factors (smoking, asthma, and relevant surgery)...
December 2016: International Forum of Allergy & Rhinology
N Benmostefa, A Bouzia, F Akaba, S Kouach, N H Guettaf, R Malek
OBJECTIFS: La mortalité dans la polyarthrite rhumatoïde (PR) est élevée en raison de la survenue d'événements cardiovasculaires. Le risque cardiovasculaire augmenté dans la PR est essentiellement lié à l'état inflammatoire chronique ainsi que d'autres facteurs comme les traitements, notamment la corticothérapie qui jouerait un rôle capital. Nous rapportant le cas d'une gangrène survenue sur athérosclérose ayant compliqué une polyarthrite rhumatoïde. MéTHODES: Patiente de 53 ans, connue et traitée pour une polyarthrite rhumatoïde depuis 20 ans, était admise pour exploration d'une ostéoporose avec une gangrène sèche du gros orteil droit...
December 2015: Annales de Cardiologie et D'angéiologie
Philipp Sievers, Lorenz Uhlmann, Sevil Korkmaz-Icöz, Christian Fastner, Florian Bea, Erwin Blessing, Hugo A Katus, Michael R Preusch
INTRODUCTION: Besides their blood pressure-lowering effects, olmesartan medoxomil and amlodipine besylate exhibit additional anti-inflammatory mechanisms in atherosclerosic disease. Most of the studies investigating the effects of atherosclerosis focused on early atherosclerotic lesions, whereas lesions in human disease, at the time when medical treatment is started, are already well established. Therefore, we set up a model of advanced atherosclerosis and investigated the effects of olmesartan medoxomil, amlodipine besylate, and the combination of both on atherosclerotic lesion size and lesion composition...
2015: Drug Design, Development and Therapy
C Brenner, W M Franz, S Kühlenthal, K Kuschnerus, F Remm, L Gross, H D Theiss, U Landmesser, N Kränkel
OBJECTIVE: Glipitins are widely used for the treatment of type 2 diabetic patients. In addition to their improvement of glycemic control, animal studies have suggested an independent anti-atherosclerotic effect of gliptins. Nevertheless, recent clinical trials regarding long-term effects of gliptin therapy on vascular events have been disappointing. This discrepancy led us to better dissect the functional role of SDF-1/CXCR4 signaling as a potential mechanism underlying gliptin action...
November 15, 2015: International Journal of Cardiology
E Carneiro Neiva Neto, M J Piatto, A Ferraz Paschôa, I De Barros Godoy, S Werner Schlaad, B Van Bellen
AIM: Compare the intima-media thickness (IMT) of the internal carotid artery with the IMT of the common and external carotid, vertebral and femoral arteries and the abdominal aorta to assess the possibility of using these arteries as markers of atherosclerotic disease. METHODS: Fifty patients with atherosclerosic risk factors were examined and the IMT was determined in the carotid arteries and compared with the values of IMT of the vertebral and femoral arteries and the abdominal aorta...
June 2015: International Angiology: a Journal of the International Union of Angiology
Roberta Della Bona, Maria Teresa Cardillo, Milena Leo, Gina Biasillo, Massimo Gustapane, Francesco Trotta, Luigi M Biasucci
OBJECTIVE: The aim of this review is to examine the role of polymorphonuclear neutrophils (PMNs) in the evolution of atherosclerosis. INTRODUCTION: While the role of PMNs in the evolution of atherosclerosic process has failed until recently to attract much attention, a body of research carried out over the last decade has disclosed the unexpectedly complex behavior of these cells, unraveling an unexpected key role for PMNs in the onset and progression of atheroma...
June 2013: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
Thomas B Clarkson, Kelly F Ethun, Haiying Chen, Debbie Golden, Edison Floyd, Susan E Appt
OBJECTIVE: The objectives of this study were to evaluate the effects of bazedoxifene acetate (BZA), a new selective estrogen receptor modulator, on coronary and peripheral artery atheroscleroses and to determine if it would antagonize the atheroprotective effects of conjugated equine estrogens (CEE) on a monkey model. METHODS: Ninety-eight surgically postmenopausal monkeys (Macaca fascicularis) were fed a moderately atherogenic diet and randomized to receive no treatment or women's equivalent doses of BZA (20 mg/d), CEE (0...
March 2013: Menopause: the Journal of the North American Menopause Society
Sudarshan Balla, Maen B Nusair, Martin A Alpert
Heart disease is the most common cause of death in patients with chronic kidney disease (CKD), particularly in those receiving dialysis. Atherosclerosic cardiovascular (CV) disease (CVD) accounts for a large number of these deaths. Atherosclerosis is accelerated in patients with CKD due predominantly to the high prevalence of traditional CVD risk factors in the CKD population. CKD aggravates pre-existent traditional risk factors such as hypertension and dyslipidemia due to secondary renal parenchymal hypertension and secondary dyslipidemia...
April 2013: Current Opinion in Pharmacology
Thomas B Clarkson, Kelly F Ethun, Haiying Chen, Debbie Golden, Edison Floyd, Susan E Appt
OBJECTIVE: The objectives of this study were to evaluate the effects of bazedoxifene acetate (BZA), a new selective estrogen receptor modulator, on coronary and peripheral artery atheroscleroses and to determine if it would antagonize the atheroprotective effects of conjugated equine estrogens (CEE) on a monkey model. METHODS: Ninety-eight surgically postmenopausal monkeys (Macaca fascicularis) were fed a moderately atherogenic diet and randomized to receive no treatment or women's equivalent doses of BZA (20 mg/d), CEE (0...
November 12, 2012: Menopause: the Journal of the North American Menopause Society
Cataldo Palmieri, Luna Gargani, Giuseppe Trianni, Marcello Ravani, Marco Vaghetti, Antonio Rizza, Dante Chiappino, Sergio Berti
This is the case of a 77 year-old man with previous coronary by-pass grafting. After the occlusion of the saphenous vein graft to marginal branch, corrected by angioplasty and stenting with a bare metal stent (BMS), during the next 4 years he experienced multiple further episodes of in-stent restenosis of the first BMS. Angioplasty was performed each time. After 4 months since the last procedure, he had new episode of unstable angina. An EKG-gated, 64-row multislice CT (MSCT) examination was performed to evaluate the venous graft lumen, showing high-grade in-stent restenosis...
September 2011: Recenti Progressi in Medicina
Baukje de Roos, Xuguang Zhang, Guillermo Rodriguez Gutierrez, Sharon Wood, Garry J Rucklidge, Martin D Reid, Gary J Duncan, Louise L Cantlay, Garry G Duthie, Niamh O'Kennedy
PURPOSE: Platelets play a key role in haemostasis and wound healing, contributing to formation of vascular plugs. They are also involved in formation of atherosclerosic plaques. Some traditional diets, like the Mediterranean diet, are associated with a lower risk of cardiovascular disease. Components in these diets may have anti-platelet functions contributing to their health benefits. METHODS: We studied the effects of alperujo extract, an olive oil production waste product containing the majority of polyphenols found in olive fruits, through measurement of effects on platelet aggregation and activation in isolated human platelets, and through identification of changes in the platelet proteome...
October 2011: European Journal of Nutrition
Mayowa O Owolabi, Okechukwu S Ogah, Adesola Ogunniyi
BACKGROUND: Vascular risk factors predispose to vertebrobasilar ischemia. Cervical osteophytes can impinge on the vertebral artery causing mechanical occlusion during head turning. Presentation with vertigo in such instances is a common finding. CASE PRESENTATION: A patient with obesity, hyperlipidemia, hypertension, cervical spondylosis, and vertigo triggered by head rotation is presented. She responded to antihypertensive and lipid-lowering drugs, vestibular sedative and application of cervical collar...
2007: Neuropsychiatric Disease and Treatment
Amparo Galán, Xavier Formiguera, Celestino Rey-Joly
The amino acid L-arginine is the substrate for endothelial nitric oxide synthesis. The endothelium is capable of producing asymmetric dimethylargine (ADMA) (L-arginine methylated). ADMA is able to compete with L-arginine in nitric oxide (NO) production and inhibits oxide nitric synthase activity. Elevated blood levels of ADMA can block the synthesis of NO, and induce endothelial dysfunction, which may lead to the initiation and progression of atherosclerosic vascular disease. Prospective clinical studies in different patients populations suggest that ADMA is a new marker in cardiovascular disease and is to able to predict new cardiovascular events...
September 6, 2008: Medicina Clínica
Erick Alexánderson, Raúl G Mendoza, Gloria Adame, José Antonio Talayero, Carlos Sierra, Patricio Cruz, Leonardo García-Rojas, Mónica Rodríguez-Valero, Armando Flores, Adolfo Zárate, Aloha Meave, Antonio Arauz
OBJECTIVES: To demonstrate that inflammatory atheromatose carotid plaques can be visualized with positron emission tomography with 18F-fluorodeoxyglucose (18FDG PET) in symptomatic patients, in order to correlate them with systemic inflammatory markers, such as CRP. METHOD: Fifteen patients with cerebral ischemia due to atherosclerotic carotid disease were studied. 18FDG uptake with PET was considered and blood samples were taken for determining high sensibility C reactive protein (HsCRP)...
October 2007: Archivos de Cardiología de México
R Menon, S Kerry, J W Norris, H S Markus
BACKGROUND AND PURPOSE: Cervical dissection is an important cause of stroke in the young. This paper presents a systematic review and a meta-analysis to assess the effectiveness of different treatment approaches: antithrombotic drugs, thrombolysis and stenting. METHODS: Medline and PubMed were searched from 1966 to 8 April 2007. Reference lists were reviewed. Separate searches were performed for treatment with anticoagulation and antiplatelet therapy during the acute phase (within 1 month of symptoms), thrombolysis and stenting...
October 2008: Journal of Neurology, Neurosurgery, and Psychiatry
Jun Yang, Zhengxiang Liu, Xiaofang Shen, Weidong Yao, Hua Qu, Mu Yang, Zhenli Gao, Daowen Wang
To investigate the expression of CD151 in human atherosclerosed artery and explore its clinical implications, Western blot and immunohistochemical techniques were used to determine the protein expression of CD151 in arterial tissues with atherosclerosis taken from 36 patients, including 26 cases who received bypass operation for peripheral artery atherosclerosis and 6 cases who died from coronary heart disease. The expression of CD151 in normal artery tissues from 15 healthy organ donators were also measured to serve as control...
2005: Journal of Huazhong University of Science and Technology. Medical Sciences
Rajeev Bansal, Patrick W Laing
Iatrogenic non-penetrating arterial injuries have been reported following primary and revision hip arthroplasties. We report a patient who developed acute limb ischaemia after dynamic hip screw fixation was performed for an unstable intertrochanteric fracture. We discuss a previously unreported mechanism of traction creating tension on the atherosclerosed vessels and medial retraction tenting and breaking the vessel wall lining. This case highlights a serious complication in one of the most commonly performed hip surgeries...
January 2006: Acta Orthopaedica Belgica
Adel El-Bialy, Michael Shenoda, Chris Caraang
Serotonin (5-hydroxytryptamine) has been recently shown to be an important mediator of coronary vasospasm. Its divergent effect on normal and atherosclerosed arteries has been demonstrated in both animal and human studies. We present a case of coronary vasospasm in a 55-year-old man with repeated episodes of chest pain following coronary percutaneous intervention. Repeat angiography demonstrated no reocclusion or complication. The patient's symptoms were resistant to treatment with maximum doses of two calcium channel antagonists and oral and intravenous nitrates, but responded to cyproheptadine, a nonselective serotonin antagonist...
February 2006: Journal of Invasive Cardiology
Mao-qiang Wang, Zhi-jun Wang, Feng-yong Liu, Zhong-pu Wang
OBJECTIVE: To evaluate the safety and efficacy of the interventional techniques for management of celiac and mesenteric arteries stenoses. METHODS: Eight patients with celiac artery (CA) or superior mesenteric artery (SMA) focal stenotic lesions were treated with percutaneous transluminal balloon angioplasty (PTA) and stent placement. CA stenosis was present in 2 patients, SMA stenosis was present in 4, and both CA and SMA were involved in 2 patients. Postprandial pain was present in 4 patients, an epigastric bruit was present in 5...
September 1, 2005: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
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